Max Krummel, PhD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-514-3130
ORCID ORCID Icon0000-0001-7915-3533 Additional info
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    Living Tumor Biopsies to Interrogate Immune Function and Response to Therapy
    NIH R21CA196468Sep 1, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Manipulating collectivity and Niches for Developing CD8 Immunity
    NIH R01AI114787Jun 15, 2015 - May 31, 2020
    Role: Principal Investigator
    CUTTING EDGE LINEAGE TRACKING OF TUMOR-EDUCATED IMMUNE CELLS
    NIH R21CA191428Jan 1, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Defining the First Hours of Lung metastasis using Intravital Live-Imaging
    NIH R21CA167601May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Leukocyte Biomarkers for Predicting Human Breast Cancer Outcomes
    NIH U54CA163123Sep 23, 2011 - Jul 31, 2017
    Role: Principal Investigator
    Multiphoton Instrumentation for Translational Assays from Human Tissue Biopsies
    NIH S10RR029266Jun 5, 2011 - Jun 4, 2013
    Role: Principal Investigator
    Collaborative Innate-Adaptive Immune Regulation of Tumor Progression
    NIH U01CA141451Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Regulation of T cell Functions by the Breast Cancer Microenvironment
    NIH R01CA134622Jul 17, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Understanding Asthma Endotypes
    NIH U19AI077439Apr 1, 2008 - Mar 31, 2023
    Role: Co-Investigator
    New Models for Molecular-Level Imaging of Cell Signaling in vivo.
    NIH R21RR024895Apr 1, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Imaging-Based Analysis of Tolerance-Induction Mechanisms
    NIH R21AI062899Mar 1, 2005 - Feb 28, 2008
    Role: Principal Investigator
    Cytoskeletal Regulation of T cell Motility and Synaptic Signaling
    NIH R01AI052116Sep 15, 2002 - Dec 31, 2017
    Role: Principal Investigator
    GENES ASSOCIATED WITH POSTTHYMIC T CELL DIFFERENTIATION
    NIH F32AI010120Mar 21, 1998 - Oct 14, 2000
    Role: Principal Investigator
    Evolving Microenvironments in Airway Inflammation
    NIH P01HL024136Jul 1, 1997 - Mar 31, 2016
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Universal Principled Review: A Community-Driven Method to Improve Peer Review. Cell. 2019 Dec 12; 179(7):1441-1445. Krummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel KM, Chi H, O'Connell R, Wherry EJ, Pepper M, Future Immunology Consortium . PMID: 31835023.
      View in: PubMed   Mentions: 1     Fields:    
    2. Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):11585-11590. Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. PMID: 30348790.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    3. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018 08; 24(8):1178-1191. Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF. PMID: 29942093.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansCells
    4. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018 05; 24(5):541-550. Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF. PMID: 29686425.
      View in: PubMed   Mentions: 664     Fields:    Translation:Humans
    5. Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. JCI Insight. 2017 Jul 20; 2(14). Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI. PMID: 28724802.
      View in: PubMed   Mentions: 17     Fields:    
    6. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 05 12; 356(6338). Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF. PMID: 28495700.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    7. Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC. Cancer Immunol Res. 2017 05; 5(5):417-424. Tumeh PC, Hellmann MD, Hamid O, Tsai KK, Loo KL, Gubens MA, Rosenblum M, Harview CL, Taube JM, Handley N, Khurana N, Nosrati A, Krummel MF, Tucker A, Sosa EV, Sanchez PJ, Banayan N, Osorio JC, Nguyen-Kim DL, Chang J, Shintaku IP, Boasberg PD, Taylor EJ, Munster PN, Algazi AP, Chmielowski B, Dummer R, Grogan TR, Elashoff D, Hwang J, Goldinger SM, Garon EB, Pierce RH, Daud A. PMID: 28411193.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCellsCTClinical Trials
    8. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. PMID: 28329764.
      View in: PubMed   Mentions: 220     Fields:    Translation:AnimalsCells
    9. Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine. JCI Insight. 2016 12 08; 1(20):e89289. Boldajipour B, Nelson A, Krummel MF. PMID: 27942588.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    10. Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell. 2016 08 08; 30(2):324-336. Roberts EW, Broz ML, Binnewies M, Headley MB, Nelson AE, Wolf DM, Kaisho T, Bogunovic D, Bhardwaj N, Krummel MF. PMID: 27424807.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    11. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. PMID: 26982733.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    12. T cell migration, search strategies and mechanisms. Nat Rev Immunol. 2016 03; 16(3):193-201. Krummel MF, Bartumeus F, Gérard A. PMID: 26852928.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    13. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. PMID: 26321127.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    14. TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 01; 195(3):1182-90. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. PMID: 26109638.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. The emerging understanding of myeloid cells as partners and targets in tumor rejection. Cancer Immunol Res. 2015 Apr; 3(4):313-9. Broz ML, Krummel MF. PMID: 25847968.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    16. A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease. J Immunol. 2015 Apr 15; 194(8):3962-9. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL. PMID: 25786688.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. PMID: 25446897.
      View in: PubMed   Mentions: 290     Fields:    Translation:HumansAnimalsCells
    18. Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g. Cell. 2014 Jul 31; 158(3):492-505. Gérard A, Patino-Lopez G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, Totah FJ, Tyska MJ, Shaw S, Krummel MF. PMID: 25083865.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    19. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug; 35(8):379-86. Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF. PMID: 24974157.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    20. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014 Oct; 30:9-16. Krummel MF, Friedman RS, Jacobelli J. PMID: 24905977.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    21. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. PMID: 24889202.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Immunity. 2014 Mar 20; 40(3):414-24. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. PMID: 24631157.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    23. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr; 14(4):356-63. Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. PMID: 23475183.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    24. Illuminating emergent activity in the immune system by real-time imaging. Nat Immunol. 2010 Jul; 11(7):554-7. Krummel MF. PMID: 20562836.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    25. The immunological synapse: a dynamic platform for local signaling. J Clin Immunol. 2010 May; 30(3):364-72. Krummel MF, Cahalan MD. PMID: 20390326.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    26. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009 Nov; 10(11):1185-92. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. PMID: 19783989.
      View in: PubMed   Mentions: 300     Fields:    Translation:AnimalsCells
    27. Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses. Curr Top Microbiol Immunol. 2009; 334:1-29. Bullen A, Friedman RS, Krummel MF. PMID: 19521679.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    28. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct; 1(2-3):155-67; discussion 165. Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. PMID: 19048079.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    29. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. PMID: 18687966.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    30. Immunological synapses: breaking up may be good to do. Cell. 2007 May 18; 129(4):653-5. Krummel MF. PMID: 17512399.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Maintenance and modulation of T cell polarity. Nat Immunol. 2006 Nov; 7(11):1143-9. Krummel MF, Macara I. PMID: 17053799.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    32. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Aug; 18(4):496-502. Tang Q, Krummel MF. PMID: 16765579.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    33. New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol. 2004 Jun; 16(3):345-52. Jacobelli J, Andres PG, Boisvert J, Krummel MF. PMID: 15134784.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    34. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol. 2002 Feb; 14(1):66-74. Krummel MF, Davis MM. PMID: 11790534.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
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