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Max Krummel, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPathology
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-514-3130
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    Collapse Research 
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    Living Tumor Biopsies to Interrogate Immune Function and Response to Therapy
    NIH R21CA196468Sep 1, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Manipulating collectivity and Niches for Developing CD8 Immunity
    NIH R01AI114787Jun 15, 2015 - May 31, 2020
    Role: Principal Investigator
    CUTTING EDGE LINEAGE TRACKING OF TUMOR-EDUCATED IMMUNE CELLS
    NIH R21CA191428Jan 1, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Defining the First Hours of Lung metastasis using Intravital Live-Imaging
    NIH R21CA167601May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH/NHLBI U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Leukocyte Biomarkers for Predicting Human Breast Cancer Outcomes
    NIH/NCI U54CA163123Sep 23, 2011 - Oct 31, 2016
    Role: Principal Investigator
    Multiphoton Instrumentation for Translational Assays from Human Tissue Biopsies
    NIH S10RR029266Jun 5, 2011 - Jun 4, 2013
    Role: Principal Investigator
    Collaborative Innate-Adaptive Immune Regulation of Tumor Progression
    NIH U01CA141451Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Regulation of T cell Functions by the Breast Cancer Microenvironment
    NIH R01CA134622Jul 17, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Understanding Asthma Endotypes
    NIH/NIAID U19AI077439Apr 1, 2008 - Mar 31, 2023
    Role: Co-Investigator
    New Models for Molecular-Level Imaging of Cell Signaling in vivo.
    NIH R21RR024895Apr 1, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Imaging-Based Analysis of Tolerance-Induction Mechanisms
    NIH R21AI062899Mar 1, 2005 - Feb 28, 2008
    Role: Principal Investigator
    Cytoskeletal Regulation of T cell Motility and Synaptic Signaling
    NIH R01AI052116Sep 15, 2002 - Dec 31, 2017
    Role: Principal Investigator
    GENES ASSOCIATED WITH POSTTHYMIC T CELL DIFFERENTIATION
    NIH F32AI010120Mar 21, 1998 - Oct 14, 2000
    Role: Principal Investigator
    Evolving Microenvironments in Airway Inflammation
    NIH/NHLBI P01HL024136Jul 1, 1979 - Mar 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 Oct 22. PMID: 30348790.
      View in: PubMed
    2. Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018 Jun 25. PMID: 29942093.
      View in: PubMed
    3. Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018 May; 24(5):541-550. PMID: 29686425.
      View in: PubMed
    4. Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI. Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. JCI Insight. 2017 07 20; 2(14). PMID: 28724802.
      View in: PubMed
    5. Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 05 12; 356(6338). PMID: 28495700.
      View in: PubMed
    6. Tumeh PC, Hellmann MD, Hamid O, Tsai KK, Loo KL, Gubens MA, Rosenblum M, Harview CL, Taube JM, Handley N, Khurana N, Nosrati A, Krummel MF, Tucker A, Sosa EV, Sanchez PJ, Banayan N, Osorio JC, Nguyen-Kim DL, Chang J, Shintaku IP, Boasberg PD, Taylor EJ, Munster PN, Algazi AP, Chmielowski B, Dummer R, Grogan TR, Elashoff D, Hwang J, Goldinger SM, Garon EB, Pierce RH, Daud A. Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC. Cancer Immunol Res. 2017 05; 5(5):417-424. PMID: 28411193.
      View in: PubMed
    7. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. PMID: 28329764.
      View in: PubMed
    8. Boldajipour B, Nelson A, Krummel MF. Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine. JCI Insight. 2016 12 08; 1(20):e89289. PMID: 27942588.
      View in: PubMed
    9. Roberts EW, Broz ML, Binnewies M, Headley MB, Nelson AE, Wolf DM, Kaisho T, Bogunovic D, Bhardwaj N, Krummel MF. Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell. 2016 08 08; 30(2):324-336. PMID: 27424807.
      View in: PubMed
    10. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7. PMID: 26982733; PMCID: PMC4892380.
    11. Krummel MF, Bartumeus F, Gérard A. T cell migration, search strategies and mechanisms. Nat Rev Immunol. 2016 03; 16(3):193-201. PMID: 26852928; PMCID: PMC4869523.
    12. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. PMID: 26321127; PMCID: PMC4573906.
    13. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 01; 195(3):1182-90. PMID: 26109638; PMCID: PMC4506848.
    14. Broz ML, Krummel MF. The emerging understanding of myeloid cells as partners and targets in tumor rejection. Cancer Immunol Res. 2015 Apr; 3(4):313-9. PMID: 25847968.
      View in: PubMed
    15. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL. A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease. J Immunol. 2015 Apr 15; 194(8):3962-9. PMID: 25786688; PMCID: PMC4390519.
    16. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52. PMID: 25446897; PMCID: PMC4254577.
    17. Gérard A, Patino-Lopez G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, Totah FJ, Tyska MJ, Shaw S, Krummel MF. Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g. Cell. 2014 Jul 31; 158(3):492-505. PMID: 25083865; PMCID: PMC4119593.
    18. Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug; 35(8):379-86. PMID: 24974157; PMCID: PMC4124173.
    19. Krummel MF, Friedman RS, Jacobelli J. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014 Oct; 30:9-16. PMID: 24905977; PMCID: PMC4178009.
    20. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. PMID: 24889202; PMCID: PMC4076593.
    21. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Immunity. 2014 Mar 20; 40(3):414-24. PMID: 24631157; PMCID: PMC4019510.
    22. Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr; 14(4):356-63. PMID: 23475183; PMCID: PMC3962671.
    23. Krummel MF. Illuminating emergent activity in the immune system by real-time imaging. Nat Immunol. 2010 Jul; 11(7):554-7. PMID: 20562836.
      View in: PubMed
    24. Krummel MF, Cahalan MD. The immunological synapse: a dynamic platform for local signaling. J Clin Immunol. 2010 May; 30(3):364-72. PMID: 20390326; PMCID: PMC2874029.
    25. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009 Nov; 10(11):1185-92. PMID: 19783989; PMCID: PMC2778301.
    26. Bullen A, Friedman RS, Krummel MF. Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses. Curr Top Microbiol Immunol. 2009; 334:1-29. PMID: 19521679.
      View in: PubMed
    27. Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct; 1(2-3):155-67; discussion 165. PMID: 19048079; PMCID: PMC2562195.
    28. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7. PMID: 18687966; PMCID: PMC2532844.
    29. Krummel MF. Immunological synapses: breaking up may be good to do. Cell. 2007 May 18; 129(4):653-5. PMID: 17512399.
      View in: PubMed
    30. Krummel MF, Macara I. Maintenance and modulation of T cell polarity. Nat Immunol. 2006 Nov; 7(11):1143-9. PMID: 17053799.
      View in: PubMed
    31. Tang Q, Krummel MF. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Aug; 18(4):496-502. PMID: 16765579.
      View in: PubMed
    32. Jacobelli J, Andres PG, Boisvert J, Krummel MF. New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol. 2004 Jun; 16(3):345-52. PMID: 15134784.
      View in: PubMed
    33. Krummel MF, Davis MM. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol. 2002 Feb; 14(1):66-74. PMID: 11790534.
      View in: PubMed
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