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Max Krummel, PhD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Phone415-514-3130
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    Living Tumor Biopsies to Interrogate Immune Function and Response to Therapy
    NIH R21CA196468Sep 1, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Manipulating collectivity and Niches for Developing CD8 Immunity
    NIH R01AI114787Jun 15, 2015 - May 31, 2020
    Role: Principal Investigator
    CUTTING EDGE LINEAGE TRACKING OF TUMOR-EDUCATED IMMUNE CELLS
    NIH R21CA191428Jan 1, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Defining the First Hours of Lung metastasis using Intravital Live-Imaging
    NIH R21CA167601May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH/NHLBI U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Leukocyte Biomarkers for Predicting Human Breast Cancer Outcomes
    NIH/NCI U54CA163123Sep 23, 2011 - Oct 31, 2016
    Role: Principal Investigator
    Multiphoton Instrumentation for Translational Assays from Human Tissue Biopsies
    NIH S10RR029266Jun 5, 2011 - Jun 4, 2013
    Role: Principal Investigator
    Collaborative Innate-Adaptive Immune Regulation of Tumor Progression
    NIH U01CA141451Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Regulation of T cell Functions by the Breast Cancer Microenvironment
    NIH R01CA134622Jul 17, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Understanding Asthma Endotypes
    NIH/NIAID U19AI077439Apr 1, 2008 - Mar 31, 2023
    Role: Co-Investigator
    New Models for Molecular-Level Imaging of Cell Signaling in vivo.
    NIH R21RR024895Apr 1, 2008 - Mar 31, 2010
    Role: Principal Investigator
    Imaging-Based Analysis of Tolerance-Induction Mechanisms
    NIH R21AI062899Mar 1, 2005 - Feb 28, 2008
    Role: Principal Investigator
    Cytoskeletal Regulation of T cell Motility and Synaptic Signaling
    NIH R01AI052116Sep 15, 2002 - Dec 31, 2017
    Role: Principal Investigator
    GENES ASSOCIATED WITH POSTTHYMIC T CELL DIFFERENTIATION
    NIH F32AI010120Mar 21, 1998 - Oct 14, 2000
    Role: Principal Investigator
    Evolving Microenvironments in Airway Inflammation
    NIH/NHLBI P01HL024136Jul 1, 1979 - Mar 31, 2015
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Krummel M. Nobel notes value of basic research for new drugs. Nature. 2018 11; 563(7730):184. PMID: 30405221.
      View in: PubMed
    2. Krummel MF, Mahale JN, Uhl LFK, Hardison EA, Mujal AM, Mazet JM, Weber RJ, Gartner ZJ, Gérard A. Paracrine costimulation of IFN-? signaling by integrins modulates CD8 T cell differentiation. Proc Natl Acad Sci U S A. 2018 Nov 06; 115(45):11585-11590. PMID: 30348790.
      View in: PubMed
    3. Hung LY, Sen D, Oniskey TK, Katzen J, Cohen NA, Vaughan AE, Nieves W, Urisman A, Beers MF, Krummel MF, Herbert DR. Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism. Mucosal Immunol. 2019 Jan; 12(1):64-76. PMID: 30337651.
      View in: PubMed
    4. Barry KC, Hsu J, Broz ML, Cueto FJ, Binnewies M, Combes AJ, Nelson AE, Loo K, Kumar R, Rosenblum MD, Alvarado MD, Wolf DM, Bogunovic D, Bhardwaj N, Daud AI, Ha PK, Ryan WR, Pollack JL, Samad B, Asthana S, Chan V, Krummel MF. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018 Aug; 24(8):1178-1191. PMID: 29942093.
      View in: PubMed
    5. Babala N, Bovens A, de Vries E, Iglesias-Guimarais V, Ahrends T, Krummel MF, Borst J, Bins AD. Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4+ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin. Cancer Immunol Res. 2018 07; 6(7):835-847. PMID: 29764836.
      View in: PubMed
    6. Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018 May; 24(5):541-550. PMID: 29686425.
      View in: PubMed
    7. Hung LY, Oniskey TK, Sen D, Krummel MF, Vaughan AE, Cohen NA, Herbert DR. Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells. Am J Pathol. 2018 May; 188(5):1161-1170. PMID: 29458008.
      View in: PubMed
    8. de Mingo Pulido Á, Gardner A, Hiebler S, Soliman H, Rugo HS, Krummel MF, Coussens LM, Ruffell B. TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer. Cancer Cell. 2018 01 08; 33(1):60-74.e6. PMID: 29316433.
      View in: PubMed
    9. Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI. Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. JCI Insight. 2017 07 20; 2(14). PMID: 28724802.
      View in: PubMed
    10. Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 05 12; 356(6338). PMID: 28495700.
      View in: PubMed
    11. Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol. 2017 Apr 28; 2(10). PMID: 28626833.
      View in: PubMed
    12. Tumeh PC, Hellmann MD, Hamid O, Tsai KK, Loo KL, Gubens MA, Rosenblum M, Harview CL, Taube JM, Handley N, Khurana N, Nosrati A, Krummel MF, Tucker A, Sosa EV, Sanchez PJ, Banayan N, Osorio JC, Nguyen-Kim DL, Chang J, Shintaku IP, Boasberg PD, Taylor EJ, Munster PN, Algazi AP, Chmielowski B, Dummer R, Grogan TR, Elashoff D, Hwang J, Goldinger SM, Garon EB, Pierce RH, Daud A. Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC. Cancer Immunol Res. 2017 05; 5(5):417-424. PMID: 28411193.
      View in: PubMed
    13. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. PMID: 28329764.
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    14. Wong PT, Roberts EW, Tang S, Mukherjee J, Cannon J, Nip AJ, Corbin K, Krummel MF, Choi SK. Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer. ACS Chem Biol. 2017 04 21; 12(4):1001-1010. PMID: 28191924.
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    15. Boldajipour B, Nelson A, Krummel MF. Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine. JCI Insight. 2016 12 08; 1(20):e89289. PMID: 27942588.
      View in: PubMed
    16. Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 12 01; 126(12):4417-4429. PMID: 27775547.
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    17. Sen D, Jones SM, Oswald EM, Pinkard H, Corbin K, Krummel MF. Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung. PLoS One. 2016; 11(10):e0165064. PMID: 27755611.
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    18. Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 10 17; 213(11):2293-2314. PMID: 27811056.
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    19. Pinkard H, Stuurman N, Corbin K, Vale R, Krummel MF. Micro-Magellan: open-source, sample-adaptive, acquisition software for optical microscopy. Nat Methods. 2016 09 29; 13(10):807-809. PMID: 27684577.
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    20. Loyher PL, Rochefort J, Baudesson de Chanville C, Hamon P, Lescaille G, Bertolus C, Guillot-Delost M, Krummel MF, Lemoine FM, Combadière C, Boissonnas A. CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity. Cancer Res. 2016 11 15; 76(22):6483-6494. PMID: 27680685.
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    21. Thanabalasuriar A, Neupane AS, Wang J, Krummel MF, Kubes P. iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation. Cell Rep. 2016 09 20; 16(12):3260-3272. PMID: 27653688.
      View in: PubMed
    22. Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach IV, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum MD. Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest. 2016 09 01; 126(9):3447-52. PMID: 27525433.
      View in: PubMed
    23. Roberts EW, Broz ML, Binnewies M, Headley MB, Nelson AE, Wolf DM, Kaisho T, Bogunovic D, Bhardwaj N, Krummel MF. Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. Cancer Cell. 2016 08 08; 30(2):324-336. PMID: 27424807.
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    24. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7. PMID: 26982733; PMCID: PMC4892380.
    25. Pinkard H, Corbin K, Krummel MF. Spatiotemporal Rank Filtering Improves Image Quality Compared to Frame Averaging in 2-Photon Laser Scanning Microscopy. PLoS One. 2016; 11(3):e0150430. PMID: 26938064.
      View in: PubMed
    26. Krummel MF, Bartumeus F, Gérard A. T cell migration, search strategies and mechanisms. Nat Rev Immunol. 2016 03; 16(3):193-201. PMID: 26852928; PMCID: PMC4869523.
    27. Jones LM, Broz ML, Ranger JJ, Ozcelik J, Ahn R, Zuo D, Ursini-Siegel J, Hallett MT, Krummel M, Muller WJ. STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis. Cancer Res. 2016 Mar 15; 76(6):1416-28. PMID: 26719528.
      View in: PubMed
    28. Mujal AM, Gilden JK, Gérard A, Kinoshita M, Krummel MF. A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Nat Immunol. 2016 Mar; 17(3):315-22. PMID: 26692174; PMCID: PMC4755847.
    29. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell. 2015 Sep 14; 34(5):493-504. PMID: 26321127; PMCID: PMC4573906.
    30. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 01; 195(3):1182-90. PMID: 26109638; PMCID: PMC4506848.
    31. Broz ML, Krummel MF. The emerging understanding of myeloid cells as partners and targets in tumor rejection. Cancer Immunol Res. 2015 Apr; 3(4):313-9. PMID: 25847968; PMCID: PMC4391275.
    32. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765; PMCID: PMC4366375.
    33. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL. A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease. J Immunol. 2015 Apr 15; 194(8):3962-9. PMID: 25786688.
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    34. Mujal AM, Krummel M. The subtle hands of self-reactivity in peripheral T cells. Nat Immunol. 2015 Jan; 16(1):10-1. PMID: 25521673; PMCID: PMC4880670.
    35. Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15; 194(2):522-30. PMID: 25505281; PMCID: PMC4282963.
    36. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Cancer Cell. 2014 Dec 08; 26(6):938. PMID: 28898680.
      View in: PubMed
    37. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52. PMID: 25446897; PMCID: PMC4254577.
    38. Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Oct 23; 124(17):2625-34. PMID: 25143486; PMCID: PMC4208278.
    39. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 07; 15(2):123-38. PMID: 25105578; PMCID: PMC4212493.
    40. Gérard A, Patino-Lopez G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, Totah FJ, Tyska MJ, Shaw S, Krummel MF. Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g. Cell. 2014 Jul 31; 158(3):492-505. PMID: 25083865; PMCID: PMC4119593.
    41. Li M, Wetzel-Strong SE, Hua X, Tilley SL, Oswald E, Krummel MF, Caron KM. Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. PLoS One. 2014; 9(7):e102356. PMID: 25010197; PMCID: PMC4092148.
    42. Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug; 35(8):379-86. PMID: 24974157; PMCID: PMC4124173.
    43. Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9223-8. PMID: 24927530; PMCID: PMC4078867.
    44. Krummel MF, Friedman RS, Jacobelli J. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014 Oct; 30:9-16. PMID: 24905977; PMCID: PMC4178009.
    45. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. PMID: 24889202; PMCID: PMC4076593.
    46. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Immunity. 2014 Mar 20; 40(3):414-24. PMID: 24631157; PMCID: PMC4019510.
    47. Corbin K, Pinkard H, Peck S, Beemiller P, Krummel MF. Assessing and benchmarking multiphoton microscopes for biologists. Methods Cell Biol. 2014; 123:135-51. PMID: 24974026.
      View in: PubMed
    48. Beemiller P, Krummel MF. Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm. Immunol Rev. 2013 Nov; 256(1):148-59. PMID: 24117819; PMCID: PMC3831008.
    49. Jacobelli J, Estin Matthews M, Chen S, Krummel MF. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers. PLoS One. 2013; 8(9):e75151. PMID: 24069389; PMCID: PMC3777879.
    50. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. PMID: 24037376; PMCID: PMC3795960.
    51. Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol. 2013 Apr; 14(4):356-63. PMID: 23475183; PMCID: PMC3962671.
    52. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75. PMID: 23290520; PMCID: PMC3576928.
    53. Gérard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan; 251(1):80-96. PMID: 23278742; PMCID: PMC3539221.
    54. Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15; 189(8):3914-24. PMID: 22962684; PMCID: PMC3509168.
    55. Beemiller P, Jacobelli J, Krummel MF. Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol. 2012 Jul 01; 13(8):787-95. PMID: 22751140; PMCID: PMC3902181.
    56. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. PMID: 22585735; PMCID: PMC3371730.
    57. Thornton EE, Krummel MF, Looney MR. Live imaging of the lung. Curr Protoc Cytom. 2012 Apr; Chapter 12:Unit12.28. PMID: 22470155.
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    58. Engelhardt JJ, Boldajipour B, Beemiller P, Pandurangi P, Sorensen C, Werb Z, Egeblad M, Krummel MF. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell. 2012 Mar 20; 21(3):402-17. PMID: 22439936; PMCID: PMC3311997.
    59. Gilden JK, Peck S, Chen YC, Krummel MF. The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol. 2012 Jan 09; 196(1):103-14. PMID: 22232702; PMCID: PMC3255977.
    60. Khan O, Headley M, Gerard A, Wei W, Liu L, Krummel MF. Regulation of T cell priming by lymphoid stroma. PLoS One. 2011; 6(11):e26138. PMID: 22110583; PMCID: PMC3215700.
    61. Krummel MF, Allison JP. Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. The journal of experimental medicine. 1995. 182: 459-465. J Immunol. 2011 Oct 01; 187(7):3459-65. PMID: 21934097.
      View in: PubMed
    62. Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 2011 Jan; 8(1):91-6. PMID: 21151136; PMCID: PMC3076005.
    63. Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010 Nov 22; 207(12):2733-49. PMID: 21041455; PMCID: PMC2989766.
    64. Katzman SD, O'Gorman WE, Villarino AV, Gallo E, Friedman RS, Krummel MF, Nolan GP, Abbas AK. Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18085-90. PMID: 20921406; PMCID: PMC2964228.
    65. Jacobelli J, Friedman RS, Conti MA, Lennon-Dumenil AM, Piel M, Sorensen CM, Adelstein RS, Krummel MF. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 2010 Oct; 11(10):953-61. PMID: 20835229; PMCID: PMC2943564.
    66. Beemiller P, Krummel MF. Mediation of T-cell activation by actin meshworks. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a002444. PMID: 20702599; PMCID: PMC2926748.
    67. Gilden J, Krummel MF. Control of cortical rigidity by the cytoskeleton: emerging roles for septins. Cytoskeleton (Hoboken). 2010 Aug; 67(8):477-86. PMID: 20540086; PMCID: PMC2906656.
    68. Krummel MF. Illuminating emergent activity in the immune system by real-time imaging. Nat Immunol. 2010 Jul; 11(7):554-7. PMID: 20562836.
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    69. Krummel MF, Cahalan MD. The immunological synapse: a dynamic platform for local signaling. J Clin Immunol. 2010 May; 30(3):364-72. PMID: 20390326; PMCID: PMC2874029.
    70. Doh J, Kim M, Krummel MF. Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials. 2010 Apr; 31(12):3422-8. PMID: 20117834.
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    71. Doh J, Krummel MF. Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions. Curr Top Microbiol Immunol. 2010; 340:25-50. PMID: 19960307.
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    72. Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol. 2009 Nov; 10(11):1185-92. PMID: 19783989; PMCID: PMC2778301.
    73. Krummel M. Matthew Krummel: visions enumerated. Interview by Amy Maxmen. J Exp Med. 2009 Jun 08; 206(6):1212-3. PMID: 19506053; PMCID: PMC2715065.
    74. Melli K, Friedman RS, Martin AE, Finger EB, Miao G, Szot GL, Krummel MF, Tang Q. Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J Immunol. 2009 Mar 01; 182(5):2590-600. PMID: 19234153; PMCID: PMC3057894.
    75. Jacobelli J, Bennett FC, Pandurangi P, Tooley AJ, Krummel MF. Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration. J Immunol. 2009 Feb 15; 182(4):2041-50. PMID: 19201857.
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    76. Bullen A, Friedman RS, Krummel MF. Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses. Curr Top Microbiol Immunol. 2009; 334:1-29. PMID: 19521679.
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    77. Tooley AJ, Gilden J, Jacobelli J, Beemiller P, Trimble WS, Kinoshita M, Krummel MF. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol. 2009 Jan; 11(1):17-26. PMID: 19043408; PMCID: PMC3777658.
    78. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85. PMID: 18832694; PMCID: PMC2657555.
    79. Egeblad M, Ewald AJ, Askautrud HA, Truitt ML, Welm BE, Bainbridge E, Peeters G, Krummel MF, Werb Z. Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech. 2008 Sep-Oct; 1(2-3):155-67; discussion 165. PMID: 19048079; PMCID: PMC2562195.
    80. Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7. PMID: 18687966; PMCID: PMC2532844.
    81. Beemiller P, Krummel MF. Distinct functions for HS1 in chemosensory versus adhesive signaling. Nat Immunol. 2008 Aug; 9(8):833-4. PMID: 18645589.
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    82. Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF. A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity. 2008 Aug 15; 29(2):238-48. PMID: 18674934; PMCID: PMC4466225.
    83. Engelhardt JJ, Krummel MF. The importance of prolonged binding to antigen-presenting cells for T cell fate decisions. Immunity. 2008 Feb; 28(2):143-5. PMID: 18275826.
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    84. Krummel MF. Testing the organization of the immunological synapse. Curr Opin Immunol. 2007 Aug; 19(4):460-2. PMID: 17689061; PMCID: PMC2039889.
    85. Krummel MF. Immunological synapses: breaking up may be good to do. Cell. 2007 May 18; 129(4):653-5. PMID: 17512399.
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    86. Krummel MF, Macara I. Maintenance and modulation of T cell polarity. Nat Immunol. 2006 Nov; 7(11):1143-9. PMID: 17053799.
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    87. Friedman RS, Jacobelli J, Krummel MF. Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol. 2006 Oct; 7(10):1101-8. PMID: 16964261.
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    88. Tang Q, Krummel MF. Imaging the function of regulatory T cells in vivo. Curr Opin Immunol. 2006 Aug; 18(4):496-502. PMID: 16765579.
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    89. Moldovan MC, Sabbagh L, Breton G, Sékaly RP, Krummel MF. Triggering of T cell activation via CD4 dimers. J Immunol. 2006 May 01; 176(9):5438-45. PMID: 16622011.
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    90. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92. PMID: 16311599; PMCID: PMC3057888.
    91. Friedman RS, Jacobelli J, Krummel MF. Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants. Semin Immunol. 2005 Dec; 17(6):387-99. PMID: 16219473.
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    92. Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, Hartley SB, O'Garra A, Cahalan MD, Cyster JG. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 2005 Jun; 3(6):e150. PMID: 15857154; PMCID: PMC1088276.
    93. Tooley AJ, Jacobelli J, Moldovan MC, Douglas A, Krummel MF. T cell synapse assembly: proteins, motors and the underlying cell biology. Semin Immunol. 2005 Feb; 17(1):65-75. PMID: 15582489.
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    94. Boisvert J, Edmondson S, Krummel MF. Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J Immunol. 2004 Sep 15; 173(6):3647-52. PMID: 15356109.
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    95. Jacobelli J, Andres PG, Boisvert J, Krummel MF. New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol. 2004 Jun; 16(3):345-52. PMID: 15134784.
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    96. Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF. CD28 signals in the immature immunological synapse. J Immunol. 2004 May 15; 172(10):5880-6. PMID: 15128767.
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    97. Jacobelli J, Chmura SA, Buxton DB, Davis MM, Krummel MF. A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol. 2004 May; 5(5):531-8. PMID: 15064761.
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    98. Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 2002 Dec; 17(6):809-22. PMID: 12479826.
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    99. Moss WC, Irvine DJ, Davis MM, Krummel MF. Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15024-9. PMID: 12415110; PMCID: PMC137538.
    100. Richie LI, Ebert PJ, Wu LC, Krummel MF, Owen JJ, Davis MM. Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. Immunity. 2002 Apr; 16(4):595-606. PMID: 11970882.
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    101. Krummel MF, Davis MM. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr Opin Immunol. 2002 Feb; 14(1):66-74. PMID: 11790534.
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