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Michael Matthay, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-353-1206
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B.1969English
    University of PennsylvaniaM.D.1973School of Medicine
    University of Colorado Medical CenterInternship and Residency1976Internal Medicine
    University of California, San FranciscoFellowship1978Pulmonary DIvision
    University of California, San FranciscoFellowship1979Cardiovascular Research Institute

    Collapse Overview 
    Collapse Overview
    Michael A. Matthay, MD is a Professor of Medicine and Anesthesia at the University of California at San Francisco and a Senior Associate at the Cardiovascular Research Institute. He is Director of the Critical Care Medicine Training in the Department of Medicine and Associate Director of the Intensive Care Unit. He received his AB from Harvard University in 1969 and his MD from the University of Pennsylvania School of Medicine in 1973. Dr. Matthay received clinical training in Internal Medicine at the University of Colorado from 1973-76 and in Pulmonary and Critical Care Medicine from the University of California at San Francisco from 1977-78. He also received research training from the Cardiovascular Physiology Laboratory, University of Colorado in 1976 and the Cardiovascular Research Institute from 1978-79.

    Michael Matthay was selected in 2006 by the UCSF Academic Senate as the recipient of the Sixth Annual Distinguished Clinical Research Lectureshi, by the American Physiological Society and the Respiration Section for the Julius Comroe Jr Award in 2009, and by the University of Paris in 20011 with an Honorary Degree (Honora Causa).

    Dr. Matthay is currently the Principal Investigator of a NIH/NHLBI-sponsored phase 1/2 clinical trial of mesenchymal stem (stromal) cells for the treatment of Acute Respiratory Distress Syndrome (START). Details of the trial may be found at the following website: http://stemcellsards.ucsf.edu.


    Collapse Research 
    Collapse Research Activities and Funding
    Prevention and Early Treatment of Acute Lung Injury
    NIH/NHLBI U01HL123004Jun 17, 2014 - Apr 30, 2021
    Role: Principal Investigator
    Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury
    NIH/NHLBI U01HL108713Sep 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH N01HR56166-16-0-1Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH N01HR56166-16-0-4Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - ALTA Protocol
    NIH/NHLBI N01HR56166Sep 30, 2005 - Sep 29, 2012
    Role: Co-Principal Investigator
    ARDS - EDEN Protocol
    NIH/NHLBI N01HR56166-6-0-3Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-7-0-1Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-9-0-1Sep 30, 2005 - Nov 30, 2011
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH/NHLBI P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    SCCOR in translational research in Acute Lung Injury
    NIH/NHLBI P50HL074005Sep 30, 2003 - Jun 30, 2010
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Resolution of Clinical Lung Injury
    NIH/NHLBI R37HL051856Apr 1, 1996 - Mar 31, 2016
    Role: Principal Investigator
    RESOLUTION OF CLINICAL LUNG INJURY
    NIH/NHLBI R01HL051856Apr 1, 1996 - Mar 31, 2006
    Role: Principal Investigator
    CCTG CLINICAL NETWORK FOR ARDS TREATMENT--CRITICAL CARE
    NIH/NHLBI N01HR046059Sep 30, 1994 - Dec 31, 2003
    Role: Principal Investigator
    Lung Fluid Balance and Mesenchymal Stem Cells
    NIH/NHLBI R01HL051854Apr 8, 1994 - Jun 30, 2013
    Role: Principal Investigator
    ALVEOLAR EPITHELIAL LIQUID AND PROTEIN CLEARANCE
    NIH/NHLBI R01HL040626Jun 1, 1988 - Nov 30, 1989
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PATHOPHYSIOLOGY OF LUNG LIQUID &PROTEIN EXCHANGE
    NIH P01HL025816Jun 1, 1980 - May 31, 1994
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Featured Videos
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Laffey JG, Matthay M. Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value. Am J Respir Crit Care Med. 2017 Aug 01; 196(3):266-273. PMID: 28306336.
      View in: PubMed
    2. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay M, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. PMID: 28737769.
      View in: PubMed
    3. Czikora I, Alli AA, Sridhar S, Matthay M, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R. Epithelial Sodium Channel-a Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction. Front Immunol. 2017; 8:842. PMID: 28785264.
      View in: PubMed
    4. Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay M, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C. Epithelial Sodium Channel ENaC is a Modifier of the Long Term Non-progressive Phenotype Associated with F508del CFTR Mutations. Am J Respir Cell Mol Biol. 2017 Jul 14. PMID: 28708422.
      View in: PubMed
    5. Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay M. Inhalation therapies in acute respiratory distress syndrome. Ann Transl Med. 2017 Jul; 5(14):293. PMID: 28828368.
      View in: PubMed
    6. Crouser ED, Matthay M. Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies. Chest. 2017 Jul; 152(1):1-3. PMID: 28693760.
      View in: PubMed
    7. Schell-Chaple HM, Liu KD, Matthay M, Sessler DI, Puntillo KA. Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Crit Care Med. 2017 Jul; 45(7):1199-1207. PMID: 28319467.
      View in: PubMed
    8. Matthay M. Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury: Basic Science and Clinical Implications. Am J Respir Crit Care Med. 2017 Jun 22. PMID: 28640648.
      View in: PubMed
    9. Kallet RH, Zhuo H, Ho K, Lipnick MS, Gomez A, Matthay M. Lung Injury Etiology and Other Factors Influencing the Relationship Between Dead-Space Fraction and Mortality in ARDS. Respir Care. 2017 Oct; 62(10):1241-1248. PMID: 28611227.
      View in: PubMed
    10. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay M, Calfee CS, Koyama T, Ware LB. External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Intensive Care Med. 2017 Aug; 43(8):1123-1131. PMID: 28593401.
      View in: PubMed
    11. Matthay M, McAuley DF, Ware LB. Clinical trials in acute respiratory distress syndrome: challenges and opportunities. Lancet Respir Med. 2017 Jun; 5(6):524-534. PMID: 28664851.
      View in: PubMed
    12. Chun LF, Moazed F, Calfee CS, Matthay M, Gotts JE. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 01; 313(2):L193-L206. PMID: 28522559.
      View in: PubMed
    13. McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay M, O'Kane CM. Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Respir Med. 2017 Jun; 5(6):484-491. PMID: 28526233.
      View in: PubMed
    14. Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay M, McAuley DF. Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol. Trials. 2017 May 11; 18(1):214. PMID: 28494790.
      View in: PubMed
    15. Gattinoni L, Pesenti A, Matthay M. Understanding blood gas analysis. Intensive Care Med. 2017 May 11. PMID: 28497267.
      View in: PubMed
    16. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay M, Sapru A. Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):858-866. PMID: 28248715.
      View in: PubMed
    17. Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay M, Levitt JE. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):798-805. PMID: 28240689.
      View in: PubMed
    18. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay M, Kain KC. Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. PLoS One. 2017; 12(4):e0175130. PMID: 28419100.
      View in: PubMed
    19. Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay M, Su X. Signals of vagal circuits engaging with AKT1 in a7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. Cell Discov. 2017; 3:17009. PMID: 28529765.
      View in: PubMed
    20. Huppert LA, Matthay M. Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome. Front Immunol. 2017; 8:371. PMID: 28439268.
      View in: PubMed
    21. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay M. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Mar 09. PMID: 28340238.
      View in: PubMed
    22. Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay M. Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset. Am J Physiol Lung Cell Mol Physiol. 2017 May 01; 312(5):L703-L709. PMID: 28258106.
      View in: PubMed
    23. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay M. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. Am J Physiol Lung Cell Mol Physiol. 2017 May 01; 312(5):L579-L585. PMID: 28213470.
      View in: PubMed
    24. Hamilton BC, Kukreja J, Ware LB, Matthay M. Protein biomarkers associated with primary graft dysfunction following lung transplantation. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 01; 312(4):L531-L541. PMID: 28130262.
      View in: PubMed
    25. Matthay M, Pati S, Lee JW. Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis. Stem Cells. 2017 Feb; 35(2):316-324. PMID: 27888550.
      View in: PubMed
    26. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay M, Kleinman SH, Brambilla D, Murphy EL. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2017 Jan; 112(1):56-63. PMID: 28001313.
      View in: PubMed
    27. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay M, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care. 2016 Nov 17; 20(1):372. PMID: 27852290.
      View in: PubMed
    28. Moore PK, Matthay M. Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful? JAMA Intern Med. 2016 Nov 01; 176(11):1660-1661. PMID: 27599363.
      View in: PubMed
    29. Matthay M, Beitler JR. Clinical, Radiographic, Physiologic, and Biologic Measurements to Facilitate Personalized Medicine for ARDS. Chest. 2016 Nov; 150(5):989-990. PMID: 27832890.
      View in: PubMed
    30. Zemans RL, Matthay M. What drives neutrophils to the alveoli in ARDS? Thorax. 2017 Jan; 72(1):1-3. PMID: 27974631.
      View in: PubMed
    31. Xu X, Greenland JR, Gotts JE, Matthay M, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501. PMID: 27716790.
      View in: PubMed
    32. Matthay M. Challenges in predicting which patients will develop ARDS. Lancet Respir Med. 2016 Nov; 4(11):847-848. PMID: 27717862.
      View in: PubMed
    33. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay M, Flori HR. Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):917-923. PMID: 27513687.
      View in: PubMed
    34. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay M, Sapru A, et al. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):907-916. PMID: 27487912.
      View in: PubMed
    35. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay M, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 Sep 08; 1(14):e87871. PMID: 27699235.
      View in: PubMed
    36. Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay M, Thompson BT, Bajwa EK. Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Sep; 44(9):1735-43. PMID: 27525994; PMCID: PMC4988326 [Available on 09/01/17].
    37. Kangelaris KN, Ware LB, Matthay M, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e771. PMID: 27428150.
      View in: PubMed
    38. Kangelaris KN, Ware LB, Matthay M, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e769-70. PMID: 27428148.
      View in: PubMed
    39. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay M, Kukreja J, Erle DJ, Collard HR, Wolters PJ. miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367. PMID: 27362652; PMCID: PMC4928999.
    40. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay M, Thompson BT, Talmor D. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. PMID: 27342819; PMCID: PMC4992404 [Available on 09/01/17].
    41. Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L, Stelmakh O, Blanch L, Serrano-Mollar A, Matthay M, Artigas A. A new experimental model of acid- and endotoxin-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 01; 311(2):L229-37. PMID: 27317688.
      View in: PubMed
    42. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay M, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 Jun; 80(6):989-97. PMID: 26881489.
      View in: PubMed
    43. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay M. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016 May 23; 20(1):151. PMID: 27215212; PMCID: PMC4876559.
    44. Gotts JE, Matthay M. Sepsis: pathophysiology and clinical management. BMJ. 2016 05 23; 353:i1585. PMID: 27217054.
      View in: PubMed
    45. Ware LB, Zhao Z, Koyama T, May AK, Matthay M, Lurmann FW, Balmes JR, Calfee CS. Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 May 15; 193(10):1143-50. PMID: 26681363; PMCID: PMC4872663 [Available on 05/15/17].
    46. Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay M, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD. Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS. Stem Cells. 2016 Aug; 34(8):2210-23. PMID: 27059413; PMCID: PMC4982045.
    47. Vieillard-Baron A, Matthay M, Teboul JL, Bein T, Schultz M, Magder S, Marini JJ. Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Intensive Care Med. 2016 May; 42(5):739-49. PMID: 27038480.
      View in: PubMed
    48. Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay M, Meduri GU. Diagnostic workup for ARDS patients. Intensive Care Med. 2016 May; 42(5):674-85. PMID: 27007111.
      View in: PubMed
    49. Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay M, Peiris JS. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3621-6. PMID: 26976597; PMCID: PMC4822574.
    50. Ernecoff NC, Witteman HO, Chon K, Chen YI, Buddadhumaruk P, Chiarchiaro J, Shotsberger KJ, Shields AM, Myers BA, Hough CL, Carson SS, Lo B, Matthay M, Anderson WG, Peterson MW, Steingrub JS, Arnold RM, White DB. Key stakeholders' perceptions of the acceptability and usefulness of a tablet-based tool to improve communication and shared decision making in ICUs. J Crit Care. 2016 Jun; 33:19-25. PMID: 27037049.
      View in: PubMed
    51. Walter JM, Matthay M, Gillespie CT, Corbridge T. Acute Hypoxemic Respiratory Failure after Large-Volume Thoracentesis. Mechanisms of Pleural Fluid Formation and Reexpansion Pulmonary Edema. Ann Am Thorac Soc. 2016 Mar; 13(3):438-43. PMID: 26963356.
      View in: PubMed
    52. Matthay M, Liu KD. New Strategies for Effective Therapeutics in Critically Ill Patients. JAMA. 2016 Feb 23; 315(8):747-8. PMID: 26903328.
      View in: PubMed
    53. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay M, McAuley DF, Calfee CS, et al. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 Dec; 71(12):1130-1136. PMID: 26839359.
      View in: PubMed
    54. Guérin C, Matthay M. Acute cor pulmonale and the acute respiratory distress syndrome. Intensive Care Med. 2016 May; 42(5):934-6. PMID: 26759013.
      View in: PubMed
    55. Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay M, Calfee CS. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Jan; 44(1):120-9. PMID: 26474112; PMCID: PMC4774861 [Available on 01/01/17].
    56. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay M, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015 Dec 14; 19:435. PMID: 26652251; PMCID: PMC4699329.
    57. Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay M, Sapru A. Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 01; 310(3):L224-31. PMID: 26660787.
      View in: PubMed
    58. Calfee CS, Matthay M, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit Care Med. 2015 Sep; 43(9):1790-7. PMID: 26010690; PMCID: PMC4737582.
    59. Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay M, Lee JW. Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):324-36. PMID: 26067592; PMCID: PMC4584251.
    60. Matthay M, Ware LB. Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology. Am J Respir Crit Care Med. 2015 Jul 15; 192(2):124-5. PMID: 26177166.
      View in: PubMed
    61. Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay M. Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. J Immunol. 2015 Aug 01; 195(3):875-81. PMID: 26116507.
      View in: PubMed
    62. Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay M, Mehta D, Reddy NM, Reddy SP. Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L414-24. PMID: 26071555; PMCID: PMC4538236.
    63. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay M, Ware LB. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Chest. 2015 Jun; 147(6):1539-1548. PMID: 26033126; PMCID: PMC4451708.
    64. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay M, Sheppard D. Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 01; 195(1):87-95. PMID: 26002979; PMCID: PMC4475475.
    65. Matthay M. Saving lives with high-flow nasal oxygen. N Engl J Med. 2015 Jun 04; 372(23):2225-6. PMID: 25982042.
      View in: PubMed
    66. Curley MA, Wypij D, Matthay M. Sedation protocol for critically ill pediatric patients--reply. JAMA. 2015 May 05; 313(17):1754-5. PMID: 25942731.
      View in: PubMed
    67. Gennai S, Monsel A, Hao Q, Park J, Matthay M, Lee JW. Microvesicles Derived From Human Mesenchymal Stem Cells Restore Alveolar Fluid Clearance in Human Lungs Rejected for Transplantation. Am J Transplant. 2015 Sep; 15(9):2404-12. PMID: 25847030; PMCID: PMC4792255.
    68. Wilson J, McKenna D, Liu KD, Matthay M. Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply. Lancet Respir Med. 2015 Apr; 3(4):e12-3. PMID: 25890655.
      View in: PubMed
    69. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay M, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13. PMID: 25795726; PMCID: PMC4451399.
    70. Matthay M. Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S54-7. PMID: 25830837; PMCID: PMC4430975.
    71. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay M. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574. PMID: 25708422.
      View in: PubMed
    72. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay M, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135.
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    80. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay M, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517; PMCID: PMC4428945.
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    85. DePianto DJ, Chandriani S, Abbas AR, Jia G, N'Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay M, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR. Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax. 2015 Jan; 70(1):48-56. PMID: 25217476; PMCID: PMC4472447.
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    90. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay M, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48. PMID: 25085625; PMCID: PMC4166786.
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    96. Sakuma T, Matthay M. Translational studies in the ex vivo human lung. Respir Investig. 2014 Jul; 52(4):219-20. PMID: 24998367.
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    107. Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay M. A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Am J Transplant. 2014 Mar; 14(3):621-8. PMID: 24730050; PMCID: PMC3986821.
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    110. Liles WC, Matthay M, Dos Santos CC, Weiss DJ, Stewart DJ. Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):363-4. PMID: 24484339.
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    130. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay M, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48. PMID: 23543053; PMCID: PMC3635736.
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    135. Seeley EJ, Rosenberg P, Matthay M. Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest. 2013 Mar; 123(3):1015-8. PMID: 23434597; PMCID: PMC3582152.
    136. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay M, McAuley DF. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol. Trials. 2013 Feb 18; 14:51. PMID: 23419093; PMCID: PMC3620926.
    137. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay M, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013 Feb 08; 18:1481-90. PMID: 23296426; PMCID: PMC3576477.
    138. Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay M, Pittet JF. Activation of the heat shock response attenuates the interleukin 1ß-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Shock. 2013 Feb; 39(2):189-96. PMID: 23324889; PMCID: PMC3663580.
    139. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. PMID: 23357450; PMCID: PMC3652681.
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    154. Folkesson HG, Kuzenko SR, Lipson DA, Matthay M, Simmons MA. The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 01; 303(3):L259-71. PMID: 22659881.
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    157. Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay M, Kuypers FA, Serikov VB. Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential. Stem Cells Transl Med. 2012 May; 1(5):359-72. PMID: 23197815; PMCID: PMC3635148.
    158. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay M, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9. PMID: 22561460; PMCID: PMC3426434.
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    162. Cha SI, Chang CS, Kim EK, Lee JW, Matthay M, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ. Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Histopathology. 2012 Jul; 61(1):98-106. PMID: 22394225; PMCID: PMC3371307.
    163. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay M. The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Am J Transplant. 2012 Jul; 12(7):1848-54. PMID: 22390401; PMCID: PMC4018219.
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    165. Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay M. Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Clin Transplant. 2012 Sep-Oct; 26(5):665-71. PMID: 22324977; PMCID: PMC3642873.
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    167. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One. 2012; 7(1):e28268. PMID: 22295056; PMCID: PMC3266233.
    168. Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay M, Zemskov EA, White R, Block NL, Schally AV. Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2084-9. PMID: 22308467; PMCID: PMC3277580.
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    170. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay M. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-1169. PMID: 22207676; PMCID: PMC3342784.
    171. Datar SA, Johnson EG, Oishi PE, Johengen M, Tang E, Aramburo A, Barton J, Kuo HC, Bennett S, Xoinis K, Reel B, Kalkan G, Sajti E, Osorio O, Raff GW, Matthay M, Fineman JR. Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L530-40. PMID: 22207591; PMCID: PMC3311527.
    172. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay M, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med. 2011 Dec; 39(12):2665-71. PMID: 21785346; PMCID: PMC3220741.
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    175. Matthay M, Kallet RH. Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome. Crit Care. 2011; 15(5):185. PMID: 22067424; PMCID: PMC3334730.
    176. Mac Sweeney R, McAuley DF, Matthay M. Acute lung failure. Semin Respir Crit Care Med. 2011 Oct; 32(5):607-25. PMID: 21989697; PMCID: PMC3601050.
    177. Matthay M, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT. Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 01; 184(5):561-8. PMID: 21562125; PMCID: PMC3175548.
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    180. Rokkam D, Lafemina MJ, Lee JW, Matthay M, Frank JA. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol. 2011 Sep; 179(3):1081-7. PMID: 21741940; PMCID: PMC3157178.
    181. Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay M. Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care. 2011 Jun 14; 1(1):20. PMID: 21906362; PMCID: PMC3224478.
    182. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay M, Liu KD. Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Ann Intensive Care. 2011 Jun 13; 1(1):18. PMID: 21906356; PMCID: PMC3224453.
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    186. Matthay M, Liu KD. Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Am J Respir Crit Care Med. 2011 May 01; 183(9):1127-8. PMID: 21531953; PMCID: PMC3114049.
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    189. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay M, Chapman HA, Wolters PJ. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L71-8. PMID: 21498628; PMCID: PMC3129898.
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    191. Cross LJ, Matthay M. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin. 2011 Apr; 27(2):355-77. PMID: 21440206; PMCID: PMC3073651.
    192. Calfee CS, Matthay M, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1660-5. PMID: 21471091; PMCID: PMC3136993.
    193. Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay M, Wright P, Ely EW. Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care. 2011; 15(2):R86. PMID: 21385351; PMCID: PMC3219344.
    194. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay M. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011 Jul; 60(7):619-32. PMID: 21301926; PMCID: PMC3116128.
    195. Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay M. Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization. J Heart Lung Transplant. 2011 Feb; 30(2):211-7. PMID: 20869266; PMCID: PMC3019270.
    196. Rey MM, Ware LB, Matthay M, Bernard GR, McGuire AL, Caplan AL, Halpern SD. Informed consent in research to improve the number and quality of deceased donor organs. Crit Care Med. 2011 Feb; 39(2):280-3. PMID: 20975549; PMCID: PMC3717371.
    197. Yamakawa N, Uchida T, Matthay M, Makita K. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Apr; 300(4):L516-25. PMID: 21257730; PMCID: PMC3075094.
    198. Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay M, Mason R, Silver RF, Kern JA. Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. J Biol Chem. 2011 Mar 25; 286(12):10660-70. PMID: 21247898; PMCID: PMC3060517.
    199. Matthay M, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 2011; 6:147-63. PMID: 20936936; PMCID: PMC3108259.
    200. Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay M, Benowitz NL, Calfee CS. Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Crit Care Med. 2011 Jan; 39(1):40-5. PMID: 20935560; PMCID: PMC3148017.
    201. Cribbs SK, Matthay M, Martin GS. Stem cells in sepsis and acute lung injury. Crit Care Med. 2010 Dec; 38(12):2379-85. PMID: 20838330; PMCID: PMC3677751.
    202. Levitt JE, Matthay M. The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition. Expert Rev Respir Med. 2010 Dec; 4(6):785-97. PMID: 21128753; PMCID: PMC3044497.
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    208. Brown LM, Kallet RH, Matthay M, Dicker RA. The influence of race on the development of acute lung injury in trauma patients. Am J Surg. 2011 Apr; 201(4):486-91. PMID: 20832050; PMCID: PMC3006033.
    209. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay M, Liu KD. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med. 2010 Sep; 38(9):1845-51. PMID: 20581666; PMCID: PMC4009623.
    210. Looney MR, Gilliss BM, Matthay M. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. PMID: 20601870.
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    211. McAuley DF, Brown LM, Matthay M. Assessing the quantity of pulmonary edema in critically ill children. Crit Care. 2010; 14(4):189. PMID: 20804574; PMCID: PMC2945115.
    212. Bastarache JA, Ong T, Matthay M, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care. 2011 Jun; 26(3):249-56. PMID: 20688464; PMCID: PMC2982881.
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    216. Matthay M, Jayr C. Acute respiratory distress syndrome after surgery: can the risk be decreased? Anesth Analg. 2010 Aug; 111(2):268-9. PMID: 20664090.
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    218. Cooke CR, Erickson SE, Watkins TR, Matthay M, Hudson LD, Rubenfeld GD. Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med. 2010 Jun; 38(6):1450-7. PMID: 20386308; PMCID: PMC3799957.
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    220. Matthay M, Idell S. Update on acute lung injury and critical care medicine 2009. Am J Respir Crit Care Med. 2010 May 15; 181(10):1027-32. PMID: 20460547; PMCID: PMC3269230.
    221. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay M, May AK, Ware LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010 May; 68(5):1121-7. PMID: 20038857; PMCID: PMC3347639.
    222. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay M, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7. PMID: 20418386; PMCID: PMC2904092.
    223. Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay M. Regulated gene expression in cultured type II cells of adult human lung. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L36-50. PMID: 20382749; PMCID: PMC2904098.
    224. Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay M, Carles M, Pittet JF. Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. Thorax. 2010 Apr; 65(4):346-53. PMID: 20388761; PMCID: PMC3118552.
    225. Kim SH, Matthay M, Mostov K, Hunt CA. Simulation of lung alveolar epithelial wound healing in vitro. J R Soc Interface. 2010 Aug 06; 7(49):1157-70. PMID: 20236957; PMCID: PMC2894878.
    226. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay M, DeLeo FR, Chambers HF. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. PMID: 20231457; PMCID: PMC2851770.
    227. Calfee CS, Matthay M. Clinical immunology: Culprits with evolutionary ties. Nature. 2010 Mar 04; 464(7285):41-2. PMID: 20203598; PMCID: PMC2857339.
    228. Matthay M. Standards and recommendations for quantitative assessment of lung structure in research. Am J Physiol Lung Cell Mol Physiol. 2010 May; 298(5):L615. PMID: 20190035; PMCID: PMC2867400.
    229. Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay M, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB. Thirty years of critical care medicine. Crit Care. 2010; 14(3):311. PMID: 20550727; PMCID: PMC2911692.
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    232. Abman SH, Matthay M. Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1039-41. PMID: 19923401.
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    233. Su X, Matthay M, Malik AB. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol. 2010 Jan 01; 184(1):401-10. PMID: 19949071; PMCID: PMC2877486.
    234. Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay M, Hashimoto S. Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury. Intensive Care Med. 2010 Mar; 36(3):479-86. PMID: 19940975; PMCID: PMC2820224.
    235. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay M, Fineman JR, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. PMID: 19830720; PMCID: PMC4427345.
    236. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay M. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest. 2010 Feb; 137(2):288-96. PMID: 19858233; PMCID: PMC2816641.
    237. Sapru A, Curley MA, Brady S, Matthay M, Flori H. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med. 2010 Jan; 36(1):157-63. PMID: 19855955; PMCID: PMC2807603.
    238. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay M. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
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    240. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay M. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur Respir J. 2010 Feb; 35(2):331-7. PMID: 19741024; PMCID: PMC2819058.
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    243. Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay M, Martin TR. Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure. Crit Care. 2009; 13(4):R134. PMID: 19671148; PMCID: PMC2750192.
    244. Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay M, Krause KH, Barazzone Argiroffo C. NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med. 2009 Nov 15; 180(10):972-81. PMID: 19661248; PMCID: PMC2778156.
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    246. McAuley DF, Matthay M. Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury. Chest. 2009 Jun; 135(6):1408-1410. PMID: 19497890.
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    248. Neyrinck AP, Liu KD, Howard JP, Matthay M. Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol. 2009 Oct; 158(4):1034-47. PMID: 19466992; PMCID: PMC2785525.
    249. Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay M, Wiener-Kronish J. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology. 2009 May; 110(5):1086-91. PMID: 19387177; PMCID: PMC4127307.
    250. Erickson SE, Martin GS, Davis JL, Matthay M, Eisner MD. Recent trends in acute lung injury mortality: 1996-2005. Crit Care Med. 2009 May; 37(5):1574-9. PMID: 19325464; PMCID: PMC2696257.
    251. Su X, Looney MR, Gupta N, Matthay M. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309; PMCID: PMC2711813.
    252. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay M, Liu KD. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol. 2009 May; 44(5):457-63. PMID: 19382217; PMCID: PMC2768264.
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    255. Su X, Matthay M. Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis. Anat Rec (Hoboken). 2009 Apr; 292(4):580-6. PMID: 19226616; PMCID: PMC3092500.
    256. Looney MR, Matthay M. Neutrophil sandwiches injure the microcirculation. Nat Med. 2009 Apr; 15(4):364-6. PMID: 19350004; PMCID: PMC2719794.
    257. Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay M, Taggart CC, Backman JT, Elborn JS, McAuley DF. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1107-14. PMID: 19324974; PMCID: PMC2695496.
    258. Kim SH, Yu W, Mostov K, Matthay M, Hunt CA. A computational approach to understand in vitro alveolar morphogenesis. PLoS One. 2009; 4(3):e4819. PMID: 19283073; PMCID: PMC2653231.
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    261. Neyrinck AP, Matthay M. The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats. Crit Care Med. 2009 Feb; 37(2):776-7. PMID: 19325385.
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    262. Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay M, Eisner MD. Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med. 2009 Jan; 37(1):1-6. PMID: 19050621; PMCID: PMC2696263.
    263. Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay M, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK. Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):155-69. PMID: 19109244; PMCID: PMC2715905.
    264. Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay M, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2009 Apr 01; 46(7):866-75. PMID: 19133325; PMCID: PMC3104854.
    265. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay M. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-275. PMID: 19017890; PMCID: PMC2714162.
    266. Ware LB, Matthay M. Beyond fishing: the role of discovery proteomics in mechanistic lung research. Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L12-3. PMID: 19011049; PMCID: PMC2636947.
    267. Looney MR, Esmon CT, Matthay M. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20. PMID: 19008297; PMCID: PMC4459744.
    268. Glassberg AE, Luce JM, Matthay M. Reasons for nonenrollment in a clinical trial of acute lung injury. Chest. 2008 Oct; 134(4):719-23. PMID: 18689583; PMCID: PMC2789486.
    269. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay M, Ware LB. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med. 2009 Feb; 35(2):248-57. PMID: 18670758; PMCID: PMC2790376.
    270. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay M. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax. 2008 Dec; 63(12):1083-9. PMID: 18566109; PMCID: PMC2764528.
    271. Seeley E, McAuley DF, Eisner M, Miletin M, Matthay M, Kallet RH. Predictors of mortality in acute lung injury during the era of lung protective ventilation. Thorax. 2008 Nov; 63(11):994-8. PMID: 18566110; PMCID: PMC2771451.
    272. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay M. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23. PMID: 18565951; PMCID: PMC2542435.
    273. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay M. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. PMID: 18496381; PMCID: PMC2442403.
    274. Su X, Johansen M, Looney MR, Brown EJ, Matthay M. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. PMID: 18453616; PMCID: PMC2771449.
    275. Matthay M, Berthiaume Y. Novel molecular strategy to prevent pulmonary edema. Crit Care Med. 2008 May; 36(5):1671-3. PMID: 18448936; PMCID: PMC2765326.
    276. Matthay M. Measurement of extravascular lung water in patients with pulmonary edema. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1021-2. PMID: 18441090.
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    279. Matthay M, Calfee CS. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest. 2008 Apr; 133(4):833-5. PMID: 18398109.
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    280. Serikov VB, Mikhaylov VM, Krasnodembskay AD, Matthay M. Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice. Lung. 2008 May-Jun; 186(3):179-190. PMID: 18357492; PMCID: PMC2863038.
    281. McClintock D, Zhuo H, Wickersham N, Matthay M, Ware LB. Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit Care. 2008; 12(2):R41. PMID: 18358078; PMCID: PMC2447583.
    282. Hunt CA, Baranzini S, Matthay M, Park S. A framework and mechanistically focused, in silico method for enabling rational translational research. Summit Transl Bioinform. 2008 Mar 01; 2008:46-50. PMID: 21347126; PMCID: PMC3041517.
    283. Matthay M, Lee J. Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Thorax. 2008 Mar; 63(3):189-90. PMID: 18308954.
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    284. Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay M, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L874-81. PMID: 18310227; PMCID: PMC2764534.
    285. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay M, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. PMID: 18276918; PMCID: PMC2739091.
    286. Liu KD, Matthay M. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clin J Am Soc Nephrol. 2008 Mar; 3(2):578-86. PMID: 18199848.
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    287. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay M, Olman MA. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol. 2008 Jan 01; 180(1):637-46. PMID: 18097066; PMCID: PMC2789491.
    288. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay M. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007 Dec; 35(12):2755-61. PMID: 18074478; PMCID: PMC3293249.
    289. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay M. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007 Oct; 35(10):2243-50. PMID: 17944012; PMCID: PMC2765812.
    290. Looney MR, Matthay M. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. PMID: 24395479.
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    291. Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay M. Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50. PMID: 17630877.
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    292. Frank JA, Pittet JF, Wray C, Matthay M. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53. PMID: 17901159.
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    293. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay M, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. PMID: 17804488.
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    294. Matthay M, Taeusch W. Surfactant treatment of aspiration-induced lung injury in children. Pediatr Crit Care Med. 2007 Sep; 8(5):505-6. PMID: 17873790.
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    297. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay M, Pinkerton KE, Sciuto AM. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal Toxicol. 2007 Aug; 19(10):789-810. PMID: 17687713.
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    299. Matthay M, Su X. Pulmonary barriers to pneumonia and sepsis. Nat Med. 2007 Jul; 13(7):780-1. PMID: 17618264.
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    300. Calfee CS, Budev MM, Matthay M, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant. 2007 Jul; 26(7):675-80. PMID: 17613396; PMCID: PMC2741136.
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    303. Berthiaume Y, Matthay M. Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol. 2007 Dec 15; 159(3):350-9. PMID: 17604701; PMCID: PMC2682357.
    304. Fudala R, Krupa A, Matthay M, Allen TC, Kurdowska AK. Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L364-74. PMID: 17513455.
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    309. Fremont RD, Kallet RH, Matthay M, Ware LB. Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest. 2007 Jun; 131(6):1742-6. PMID: 17413051; PMCID: PMC2783608.
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    314. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay M, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496; PMCID: PMC1855040.
    315. Flori HR, Ware LB, Milet M, Matthay M. Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2007 Mar; 8(2):96-101. PMID: 17273112; PMCID: PMC3586228.
    316. Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay M. Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome. Clin Chest Med. 2006 Dec; 27(4):627-35; abstract ix. PMID: 17085251.
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    318. Ning W, Dong Y, Sun J, Li C, Matthay M, Feghali-Bostwick CA, Choi AM. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):480-90. PMID: 17099140; PMCID: PMC1899323.
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    320. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay M, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov; 12(11):1286-93. PMID: 17086189; PMCID: PMC2768268.
    321. McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay M. Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med. 2007 Feb 01; 175(3):256-62. PMID: 17082495; PMCID: PMC1899263.
    322. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay M, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. PMID: 17079779; PMCID: PMC1899321.
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    326. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay M, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21. PMID: 16793871.
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    327. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay M. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 2006 Sep; 32(9):1293-303. PMID: 16770611.
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    328. Wiener-Kronish JP, Matthay M. Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury. Crit Care Med. 2006 Jun; 34(6):1841-2. PMID: 16714996.
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    329. Gupta N, Matthay M. Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7. PMID: 16714999.
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    330. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay M. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475; PMCID: PMC1462945.
    331. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay M, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14. PMID: 16710477; PMCID: PMC1462943.
    332. Guidot DM, Folkesson HG, Jain L, Sznajder JI, Pittet JF, Matthay M. Integrating acute lung injury and regulation of alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L301-6. PMID: 16698856.
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    333. McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay M. Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L566-71. PMID: 16698854; PMCID: PMC2765125.
    334. Liu KD, Matthay M, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clin J Am Soc Nephrol. 2006 Jul; 1(4):869-73. PMID: 17699299.
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    335. Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay M, Fleshner M, Pittet JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L354-61. PMID: 16679378; PMCID: PMC2765126.
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    337. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay M. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6. PMID: 16618787.
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    338. Cepkova M, Matthay M. Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med. 2006 May-Jun; 21(3):119-43. PMID: 16672636; PMCID: PMC2765330.
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    344. Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay M, Burlingame AL, Maher JJ, Niemann CU. Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Mol Cell Proteomics. 2006 Jun; 5(6):979-86. PMID: 16500929.
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    349. Ware LB, Matthay M. Clinical practice. Acute pulmonary edema. N Engl J Med. 2005 Dec 29; 353(26):2788-96. PMID: 16382065.
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    350. Han B, Mura M, Andrade CF, Okutani D, Lodyga M, dos Santos CC, Keshavjee S, Matthay M, Liu M. TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. J Immunol. 2005 Dec 15; 175(12):8303-11. PMID: 16339571.
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    353. Folkesson HG, Chapin CJ, Beard LL, Ertsey R, Matthay M, Kitterman JA. Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses. Am J Physiol Lung Cell Mol Physiol. 2006 Mar; 290(3):L478-84. PMID: 16214817.
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    355. Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay M. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant. 2005 Oct; 24(10):1650-6. PMID: 16210143.
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    356. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay M. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9. PMID: 16143588.
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    357. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay M. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. PMID: 16081834.
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    358. Frank JA, Matthay M. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 01; 172(3):261-2. PMID: 16040787; PMCID: PMC2718469.
    359. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay M, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37. PMID: 16014597; PMCID: PMC1237036.
    360. Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay M. VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Eur Respir J. 2005 Jul; 26(1):101-5. PMID: 15994395; PMCID: PMC2757043.
    361. Calfee CS, Matthay M. Recent advances in mechanical ventilation. Am J Med. 2005 Jun; 118(6):584-91. PMID: 15922687.
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    362. Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay M, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):231-47. PMID: 15891109; PMCID: PMC2715314.
    363. Kallet RH, Daniel BM, Garcia O, Matthay M. Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method. Respir Care. 2005 Apr; 50(4):462-7. PMID: 15807908.
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    364. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay M. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L104-10. PMID: 15781423.
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    365. Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E. Critical care in AJRCCM 2004. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):537-44. PMID: 15753483.
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    366. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay M, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005 May 13; 280(19):18579-89. PMID: 15755725.
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    367. Planès C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B. In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1099-109. PMID: 15681398.
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    368. Matthay M, Robriquet L, Fang X. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc Am Thorac Soc. 2005; 2(3):206-13. PMID: 16222039.
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    369. McAuley DF, Matthay M. Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome? Treat Respir Med. 2005; 4(5):297-307. PMID: 16137187.
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    370. Parsons PE, Eisner MD, Thompson BT, Matthay M, Ancukiewicz M, Bernard GR, Wheeler AP. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med. 2005 Jan; 33(1):1-6; discussion 230-2. PMID: 15644641.
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    371. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay M. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. PMID: 15644667.
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    372. Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay M. Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Crit Care Med. 2005 Jan; 33(1):63-70; discussion 239-40. PMID: 15644650.
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    373. Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay M, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005 Jan; 118(1):11-8. PMID: 15639202.
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    374. Flori HR, Glidden DV, Rutherford GW, Matthay M. Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality. Am J Respir Crit Care Med. 2005 May 01; 171(9):995-1001. PMID: 15618461.
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    375. Mehta D, Bhattacharya J, Matthay M, Malik AB. Integrated control of lung fluid balance. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1081-90. PMID: 15531757.
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    376. Lee H, Pespeni M, Roux J, Dennery PA, Matthay M, Pittet JF. HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J. 2005 Feb; 19(2):287-9. PMID: 15550551.
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    377. Matthay M, Ware LB. Can nicotine treat sepsis? Nat Med. 2004 Nov; 10(11):1161-2. PMID: 15516907.
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    378. Parsons PE, Matthay M, Ware LB, Eisner MD. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L426-31. PMID: 15516488.
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    379. Bandi VD, Munnur U, Matthay M. Acute lung injury and acute respiratory distress syndrome in pregnancy. Crit Care Clin. 2004 Oct; 20(4):577-607. PMID: 15388190.
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    380. Kallet RH, Alonso JA, Pittet JF, Matthay M. Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. Respir Care. 2004 Sep; 49(9):1008-14. PMID: 15329171.
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    381. Su X, Looney M, Robriquet L, Fang X, Matthay M. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. PMID: 15524406.
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    382. Pugin J, Stern-Voeffray S, Daubeuf B, Matthay M, Elson G, Dunn-Siegrist I. Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood. 2004 Dec 15; 104(13):4071-9. PMID: 15328161.
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    383. Brower RG, Lanken PN, MacIntyre N, Matthay M, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22; 351(4):327-36. PMID: 15269312.
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    384. Sue RD, Matthay M, Ware LB. Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Intensive Care Med. 2004 Oct; 30(10):1921-6. PMID: 15258730.
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    385. Looney MR, Gropper MA, Matthay M. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
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    386. McAuley DF, Frank JA, Fang X, Matthay M. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. PMID: 15241090.
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    387. Matthay M, Clements JA. Coagulation-dependent mechanisms and asthma. J Clin Invest. 2004 Jul; 114(1):20-3. PMID: 15232607; PMCID: PMC437975.
    388. Hirsch J, Hansen KC, Burlingame AL, Matthay M. Proteomics: current techniques and potential applications to lung disease. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L1-23. PMID: 15187006.
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    389. Zemans RL, Matthay M. Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury. Crit Care. 2004 Dec; 8(6):469-77. PMID: 15566618; PMCID: PMC1065044.
    390. Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay M. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med. 2004 Oct 01; 170(7):766-72. PMID: 15201135.
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    391. Matthay M, Ware LB. Plasma protein C levels in patients with acute lung injury: prognostic significance. Crit Care Med. 2004 May; 32(5 Suppl):S229-32. PMID: 15118523.
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    392. Geiser T, Ishigaki M, van Leer C, Matthay M, Broaddus VC. H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L448-53. PMID: 15121637.
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    393. Hastings RH, Folkesson HG, Matthay M. Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L679-89. PMID: 15003932.
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    394. Zemans RL, Chatterjee K, Matthay M. Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Am J Med. 2004 Mar 15; 116(6):424-6. PMID: 15006593.
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    395. Fang X, Song Y, Zemans R, Hirsch J, Matthay M. Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L104-10. PMID: 14990396.
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    396. Sakuma T, Zhao Y, Sugita M, Sagawa M, Toga H, Ishibashi T, Nishio M, Matthay M. Malnutrition impairs alveolar fluid clearance in rat lungs. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1268-74. PMID: 14977628.
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    397. Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay M. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol. 2004 Feb 15; 172(4):2668-77. PMID: 14764742.
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    398. Gropper MA, Matthay M. Look before you leap: how do intensivists improve care for critically ill patients? Am J Med. 2004 Feb 01; 116(3):206-7. PMID: 14749169.
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    399. McClintock DE, Matthay M. Why does acute lung injury have no impact on mortality in patients with major trauma? Crit Care Med. 2004 Feb; 32(2):583-4. PMID: 14758183.
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    400. Uchida T, Rossignol F, Matthay M, Mounier R, Couette S, Clottes E, Clerici C. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem. 2004 Apr 09; 279(15):14871-8. PMID: 14744852.
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    402. Krupa A, Kato H, Matthay M, Kurdowska AK. Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1105-13. PMID: 14729508.
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    403. Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay M, Engel JN. The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun. 2004 Jan; 72(1):546-58. PMID: 14688136; PMCID: PMC343945.
    404. Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay M. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp Lung Res. 2004 Jan-Feb; 30(1):31-42. PMID: 14967602.
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    405. Pastor CM, Matthay M, Frossard JL. Pancreatitis-associated acute lung injury: new insights. Chest. 2003 Dec; 124(6):2341-51. PMID: 14665518.
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    406. Goodman RB, Pugin J, Lee JS, Matthay M. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 2003 Dec; 14(6):523-35. PMID: 14563354.
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    407. Clerici C, Matthay M. Transforming growth factor-beta 1 regulates lung epithelial barrier function and fluid transport. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1190-1. PMID: 14604849.
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    408. Paine R, Wilcoxen SE, Morris SB, Sartori C, Baleeiro CE, Matthay M, Christensen PJ. Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury. Am J Pathol. 2003 Dec; 163(6):2397-406. PMID: 14633611; PMCID: PMC1892382.
    409. Eisner MD, Parsons P, Matthay M, Ware L, Greene K. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax. 2003 Nov; 58(11):983-8. PMID: 14586055; PMCID: PMC1746524.
    410. Brower RG, Morris A, MacIntyre N, Matthay M, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med. 2003 Nov; 31(11):2592-7. PMID: 14605529.
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    411. Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay M. Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intensive Care Med. 2003 Nov; 29(11):2034-42. PMID: 14557856.
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    412. Cheng IW, Matthay M. Acute lung injury and the acute respiratory distress syndrome. Crit Care Clin. 2003 Oct; 19(4):693-712. PMID: 14601715.
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    413. Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay M, Hashimoto S. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1088-94. PMID: 12959931.
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    414. Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay M, Day BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med. 2003 Sep; 31(9):2309-15. PMID: 14501961.
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    415. Olman MA, Matthay M. Transforming growth factor-beta induces fibrosis in immune cell-depleted lungs. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L522-6. PMID: 12902316.
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    416. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay M, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. PMID: 12930837.
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    417. Elia N, Tapponnier M, Matthay M, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R. Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1043-50. PMID: 12842853.
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    418. Flori HR, Ware LB, Glidden D, Matthay M. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2003 Jul; 4(3):315-21. PMID: 12831413.
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    419. Ware LB, Fang X, Matthay M. Protein C and thrombomodulin in human acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L514-21. PMID: 12754194.
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    420. Prabhakaran P, Ware LB, White KE, Cross MT, Matthay M, Olman MA. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L20-8. PMID: 12730079.
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    421. Matthay M, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2003 Apr 01; 167(7):1027-35. PMID: 12663342.
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    422. Folkesson HG, Matthay M. Therapeutic strategies to hasten the resolution of pulmonary edema. Crit Care Med. 2003 Apr; 31(4):1288-9. PMID: 12682513.
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    423. Collard HR, Saint S, Matthay M. Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Ann Intern Med. 2003 Mar 18; 138(6):494-501. PMID: 12639084.
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    424. Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res. 2003 Feb 15; 283(2):215-29. PMID: 12581741.
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    425. Frank JA, Pittet JF, Lee H, Godzich M, Matthay M. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L791-8. PMID: 12562562.
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    426. Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay M. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit Care Med. 2003 Jan; 31(1):20-7. PMID: 12544988.
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    427. Berthiaume Y, Folkesson HG, Matthay M. Lung edema clearance: 20 years of progress: invited review: alveolar edema fluid clearance in the injured lung. J Appl Physiol (1985). 2002 Dec; 93(6):2207-13. PMID: 12433940.
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    428. Matthay M. Alveolar fluid clearance in patients with ARDS: does it make a difference? Chest. 2002 Dec; 122(6 Suppl):340S-343S. PMID: 12475812.
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    429. Brower RG, Matthay M, Schoenfeld D. Meta-analysis of acute lung injury and acute respiratory distress syndrome trials. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1515-7. PMID: 12450936.
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    430. Matthay M. Clinical measurement of pulmonary edema. Chest. 2002 Dec; 122(6):1877-9. PMID: 12475816.
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    431. Sartori C, Matthay M. Alveolar epithelial fluid transport in acute lung injury: new insights. Eur Respir J. 2002 Nov; 20(5):1299-313. PMID: 12449188.
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    432. Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay M, Ware LB. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol. 2002 Nov; 161(5):1783-96. PMID: 12414525; PMCID: PMC1850801.
    433. Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay M, Clerici C. Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L1133-42. PMID: 12376368.
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    434. Sartori C, Fang X, McGraw DW, Koch P, Snider ME, Folkesson HG, Matthay M. Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice. J Appl Physiol (1985). 2002 Nov; 93(5):1875-80. PMID: 12381778.
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    435. Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay M. Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. J Appl Physiol (1985). 2002 Nov; 93(5):1869-74. PMID: 12381777.
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    436. Ware LB, Matthay M. Measuring microvascular blood flow in sepsis--a continuing challenge. Lancet. 2002 Oct 19; 360(9341):1187-8. PMID: 12401242.
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    437. Frank JA, Matthay M. Science review: mechanisms of ventilator-induced injury. Crit Care. 2003 Jun; 7(3):233-41. PMID: 12793874; PMCID: PMC270664.
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    439. Matthay M, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R. Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L678-82. PMID: 12225942.
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    440. Lane RK, Matthay M. Central line infections. Curr Opin Crit Care. 2002 Oct; 8(5):441-8. PMID: 12357113.
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    441. Sakuma T, Sagawa M, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Matthay M. Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs. J Thorac Cardiovasc Surg. 2002 Oct; 124(4):668-74. PMID: 12324723.
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    442. Matthay M, Clerici C, Saumon G. Invited review: Active fluid clearance from the distal air spaces of the lung. J Appl Physiol (1985). 2002 Oct; 93(4):1533-41. PMID: 12235056.
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    444. Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet. 2002 Aug 24; 360(9333):619-20. PMID: 12241936.
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    445. Matthay M. The pulmonary epithelium is an important mediator of ventilator-induced lung injury. Crit Care Med. 2002 Aug; 30(8):1910-1. PMID: 12163818.
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    446. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay M, Ware LB. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L163-9. PMID: 12060573.
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    447. Fang X, Yang B, Matthay M, Verkman AS. Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. J Physiol. 2002 Jul 01; 542(Pt 1):63-9. PMID: 12096051; PMCID: PMC2290384.
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    449. Saint S, Savel RH, Matthay M. Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections. Am J Respir Crit Care Med. 2002 Jun 01; 165(11):1475-9. PMID: 12045119.
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    450. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay M. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med. 2002 Jun; 28(6):705-11. PMID: 12107675.
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    451. Atabai K, Matthay M. The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology. Thorax. 2002 May; 57(5):452-8. PMID: 11978926; PMCID: PMC1746331.
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    453. Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay M. Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L1092-8. PMID: 11943675.
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    557. Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay M. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug; 156(2 Pt 1):438-44. PMID: 9279221.
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    558. Folkesson HG, Matthay M. Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits. J Appl Physiol (1985). 1997 Jun; 82(6):1743-50. PMID: 9173936.
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    559. Jasmer RM, Luce JM, Matthay M. Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated? Chest. 1997 Jun; 111(6):1672-8. PMID: 9187192.
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    560. Garat C, Meignan M, Matthay M, Luo DF, Jayr C. Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats. Chest. 1997 May; 111(5):1381-8. PMID: 9149598.
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    561. Smith WS, Matthay M. Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest. 1997 May; 111(5):1326-33. PMID: 9149590.
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    562. Oliver BL, Garat C, Pytela R, Matthay M. Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix. Am J Respir Cell Mol Biol. 1997 May; 16(5):613-20. PMID: 9160844.
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    563. Pittet JF, Mackersie RC, Martin TR, Matthay M. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med. 1997 Apr; 155(4):1187-205. PMID: 9105054.
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    564. Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay M. Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury. Chest. 1997 Mar; 111(3):652-6. PMID: 9118703.
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    565. Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay M. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Am J Respir Crit Care Med. 1997 Feb; 155(2):506-12. PMID: 9032186.
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    566. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay M, Jayr C. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. J Clin Invest. 1997 Jan 15; 99(2):325-35. PMID: 9006001; PMCID: PMC507800.
    567. Sakuma T, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay M. Increased alveolar fluid clearance following thoracotomy: report of a case and results of an analysis. Surg Today. 1997; 27(8):762-5. PMID: 9306595.
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    568. Umenishi F, Carter EP, Yang B, Oliver B, Matthay M, Verkman AS. Sharp increase in rat lung water channel expression in the perinatal period. Am J Respir Cell Mol Biol. 1996 Nov; 15(5):673-9. PMID: 8918374.
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    569. Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay M. Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro. Am J Physiol. 1996 Nov; 271(5 Pt 1):L844-53. PMID: 8944729.
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    570. Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay M, Brelsford WG, Cohen AB. Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. J Immunol. 1996 Sep 15; 157(6):2699-706. PMID: 8805676.
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    571. Miller EJ, Cohen AB, Matthay M. Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med. 1996 Sep; 24(9):1448-54. PMID: 8797614.
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    572. Carter EP, Matthay M, Farinas J, Verkman AS. Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method. J Gen Physiol. 1996 Sep; 108(3):133-42. PMID: 8882859; PMCID: PMC2229323.
    573. Folkesson HG, Pittet JF, Nitenberg G, Matthay M. Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats. Am J Physiol. 1996 Aug; 271(2 Pt 1):L236-44. PMID: 8770062.
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    574. Pittet JF, Brenner TJ, Modelska K, Matthay M. Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats. J Appl Physiol (1985). 1996 Aug; 81(2):830-7. PMID: 8872653.
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    575. Matthay M, Rosen GD. Acid aspiration induced lung injury. New insights and therapeutic options. Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 1):277-8. PMID: 8756794.
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    576. Matthay M. The acute respiratory distress syndrome. N Engl J Med. 1996 May 30; 334(22):1469-70. PMID: 8618587.
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    577. Folkesson HG, Matthay M, Weström BR, Kim KJ, Karlsson BW, Hastings RH. Alveolar epithelial clearance of protein. J Appl Physiol (1985). 1996 May; 80(5):1431-45. PMID: 8727524.
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    578. Sakuma T, Suzuki S, Usuda K, Handa M, Okaniwa G, Nakada T, Fujimura S, Matthay M. Preservation of alveolar epithelial fluid transport mechanisms in rewarmed human lung after severe hypothermia. J Appl Physiol (1985). 1996 May; 80(5):1681-6. PMID: 8727555.
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    579. DiFederico EM, Harrison M, Matthay M. Pulmonary edema in a woman following fetal surgery. Chest. 1996 Apr; 109(4):1114-7. PMID: 8635343.
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    580. Matthay M, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol. 1996 Apr; 270(4 Pt 1):L487-503. PMID: 8928808.
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    581. Folkesson HG, Matthay M, Frigeri A, Verkman AS. Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport. J Clin Invest. 1996 Feb 01; 97(3):664-71. PMID: 8609221; PMCID: PMC507102.
    582. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay M, Wiener-Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 Jan 01; 183(1):109-17. PMID: 8551213; PMCID: PMC2192426.
    583. Garat C, Rezaiguia S, Meignan M, D'Ortho MP, Harf A, Matthay M, Jayr C. Alveolar endotoxin increases alveolar liquid clearance in rats. J Appl Physiol (1985). 1995 Dec; 79(6):2021-8. PMID: 8847269.
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    584. Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay M. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med. 1995 Dec; 152(6 Pt 1):1818-24. PMID: 8520742.
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    585. Hastings RH, Folkesson HG, Petersen V, Ciriales R, Matthay M. Cellular uptake of albumin from lungs of anesthetized rabbits. Am J Physiol. 1995 Oct; 269(4 Pt 1):L453-62. PMID: 7485517.
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    586. Folkesson HG, Matthay M, Hébert CA, Broaddus VC. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest. 1995 Jul; 96(1):107-16. PMID: 7615779; PMCID: PMC185178.
    587. Rubenfeld GD, Doyle RL, Matthay M. Evaluation of definitions of ARDS. Am J Respir Crit Care Med. 1995 Apr; 151(4):1270-1. PMID: 7697267.
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    588. Pittet JF, Wiener-Kronish JP, Serikov V, Matthay M. Resistance of the alveolar epithelium to injury from septic shock in sheep. Am J Respir Crit Care Med. 1995 Apr; 151(4):1093-100. PMID: 7697237.
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    589. Schwartz DE, Matthay M, Cohen NH. Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations. Anesthesiology. 1995 Feb; 82(2):367-76. PMID: 7856895.
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    590. Schnapp LM, Chin DP, Szaflarski N, Matthay M. Frequency and importance of barotrauma in 100 patients with acute lung injury. Crit Care Med. 1995 Feb; 23(2):272-8. PMID: 7867352.
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    591. Matthay M. Fibrosing alveolitis in the adult respiratory distress syndrome. Ann Intern Med. 1995 Jan 01; 122(1):65-6. PMID: 7985899.
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    592. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay M. Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Am J Physiol. 1994 Dec; 267(6 Pt 1):L728-38. PMID: 7810677.
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    593. Folkesson HG, Kheradmand F, Matthay M. The effect of salt water on alveolar epithelial barrier function. Am J Respir Crit Care Med. 1994 Dec; 150(6 Pt 1):1555-63. PMID: 7952614.
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    594. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay M. Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med. 1994 Aug; 150(2):305-10. PMID: 8049807.
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    595. Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay M. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats. J Clin Invest. 1994 Aug; 94(2):663-71. PMID: 8040320; PMCID: PMC296144.
    596. Jayr C, Garat C, Meignan M, Pittet JF, Zelter M, Matthay M. Alveolar liquid and protein clearance in anesthetized ventilated rats. J Appl Physiol (1985). 1994 Jun; 76(6):2636-42. PMID: 7928894.
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    597. Folkesson HG, Matthay M, Hasegawa H, Kheradmand F, Verkman AS. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4970-4. PMID: 7515184; PMCID: PMC43911.
    598. Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay M. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Am J Physiol. 1994 May; 266(5 Pt 1):L544-52. PMID: 8203547.
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    599. Matthay M. Function of the alveolar epithelial barrier under pathologic conditions. Chest. 1994 Mar; 105(3 Suppl):67S-74S. PMID: 8131616.
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    600. Hasegawa H, Ma T, Skach W, Matthay M, Verkman AS. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem. 1994 Feb 25; 269(8):5497-500. PMID: 7509789.
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    601. Kelly BJ, Matthay M. Prevalence and severity of neurologic dysfunction in critically ill patients. Influence on need for continued mechanical ventilation. Chest. 1993 Dec; 104(6):1818-24. PMID: 8252971.
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    602. Matthay M, Thiery JP, Lafont F, Stampfer F, Boyer B. Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line. J Cell Sci. 1993 Nov; 106 ( Pt 3):869-78. PMID: 8308069.
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    603. Matthay M, Folkesson HG, Campagna A, Kheradmand F. Alveolar epithelial barrier and acute lung injury. New Horiz. 1993 Nov; 1(4):613-22. PMID: 8087581.
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    604. Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay M. Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. J Appl Physiol (1985). 1993 Oct; 75(4):1661-9. PMID: 8282618.
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    605. Pittet JF, Matthay M, Pier G, Grady M, Wiener-Kronish JP. Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody. J Clin Invest. 1993 Sep; 92(3):1221-8. PMID: 8376581; PMCID: PMC288261.
    606. Serikov VB, Grady M, Matthay M. Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung. J Appl Physiol (1985). 1993 Aug; 75(2):940-7. PMID: 8226499.
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    607. Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder RJ, Martin TR, Wiener-Kronish JP, Matthay M. Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS. Am J Physiol. 1993 May; 264(5 Pt 1):L490-5. PMID: 8498526.
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    608. Jayr C, Matthay M, Goldstone J, Gold WM, Wiener-Kronish JP. Preoperative and intraoperative factors associated with prolonged mechanical ventilation. A study in patients following major abdominal vascular surgery. Chest. 1993 Apr; 103(4):1231-6. PMID: 8131471.
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    609. Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay M. Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol. 1993 Jan 15; 150(2):644-54. PMID: 7678280.
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    610. Sakuma T, Pittet JF, Jayr C, Matthay M. Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep. J Appl Physiol (1985). 1993 Jan; 74(1):176-85. PMID: 7680335.
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    611. Espiritu RF, Pittet JF, Matthay M, Goetzl EJ. Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. Inflammation. 1992 Oct; 16(5):509-17. PMID: 1428125.
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    612. Hastings RH, Grady M, Sakuma T, Matthay M. Clearance of different-sized proteins from the alveolar space in humans and rabbits. J Appl Physiol (1985). 1992 Oct; 73(4):1310-6. PMID: 1447074.
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    613. Cohen DS, Matthay M, Cogan MG, Murray JF. Pulmonary edema associated with salt water near-drowning: new insights. Am Rev Respir Dis. 1992 Sep; 146(3):794-6. PMID: 1519866.
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    614. Segredo V, Caldwell JE, Matthay M, Sharma ML, Gruenke LD, Miller RD. Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med. 1992 Aug 20; 327(8):524-8. PMID: 1353252.
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    615. Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E, Matthay M. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis. 1992 Aug; 146(2):427-32. PMID: 1489135.
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    616. Kilpatrick SJ, Matthay M. Obstetric patients requiring critical care. A five-year review. Chest. 1992 May; 101(5):1407-12. PMID: 1582306.
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    617. Callaham M, Barton C, Matthay M. Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest. Crit Care Med. 1992 Mar; 20(3):337-43. PMID: 1541094.
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    618. Jayr C, Matthay M. Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep. J Appl Physiol (1985). 1991 Nov; 71(5):1679-87. PMID: 1761463.
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    619. Wiener-Kronish JP, Albertine KH, Matthay M. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest. 1991 Sep; 88(3):864-75. PMID: 1885774; PMCID: PMC295473.
    620. Matthay M, Matthay RA. Critical care medicine. JAMA. 1991 Jun 19; 265(23):3109-11. PMID: 2041115.
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    621. Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay M. Alveolar and lung liquid clearance in anesthetized rabbits. J Appl Physiol (1985). 1991 Apr; 70(4):1827-35. PMID: 2055861.
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    622. Chatterjee K, Matthay M. Right-heart catheterization is a diagnostic procedure not a therapeutic intervention. J Intensive Care Med. 1991 Mar-Apr; 6(2):101-4. PMID: 10147954.
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    623. Matthay M. Resolution of pulmonary edema. New insights. West J Med. 1991 Mar; 154(3):315-21. PMID: 2028590; PMCID: PMC1002752.
    624. Wiedemann HP, Matthay M, Gillis CN. Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance. Clin Chest Med. 1990 Dec; 11(4):723-36. PMID: 2268998.
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    625. Matthay M. The adult respiratory distress syndrome. Definition and prognosis. Clin Chest Med. 1990 Dec; 11(4):575-80. PMID: 2268989.
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    626. Matthay M, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1250-7. PMID: 2252240.
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    627. Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay M. Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest. 1990 Aug; 86(2):474-80. PMID: 2384595; PMCID: PMC296749.
    628. Wiener-Kronish JP, Gropper MA, Matthay M. The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Br J Anaesth. 1990 Jul; 65(1):107-29. PMID: 2200479.
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    629. Heffner JE, Matthay M. The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson". J Lab Clin Med. 1990 Apr; 115(4):394-5. PMID: 2324608.
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    630. Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay M. Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Anesthesiology. 1990 Apr; 72(4):607-12. PMID: 2321775.
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    631. Segredo V, Matthay M, Sharma ML, Gruenke LD, Caldwell JE, Miller RD. Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients. Anesthesiology. 1990 Mar; 72(3):566-70. PMID: 1968730.
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    632. Brüssel T, Matthay M, Chernow B. Pulmonary manifestations of endocrine and metabolic disorders. Clin Chest Med. 1989 Dec; 10(4):645-53. PMID: 2689069.
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    633. Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay M. Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h. J Appl Physiol (1985). 1989 Nov; 67(5):1887-97. PMID: 2600023.
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    634. Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay M. Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest. 1989 Nov; 84(5):1609-19. PMID: 2553777; PMCID: PMC304027.
    635. Matthay M. New modes of mechanical ventilation for ARDS. How should they be evaluated? Chest. 1989 Jun; 95(6):1175-7. PMID: 2721246.
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    636. Baskin L, Mee S, Matthay M, Carroll PR. Ureteral obstruction caused by vasculitis. J Urol. 1989 Apr; 141(4):933-5. PMID: 2564444.
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    637. Matthay M, Wiener-Kronish JP. Respiratory management after cardiac surgery. Chest. 1989 Feb; 95(2):424-34. PMID: 2914495.
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    638. Matthay M. The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment. West J Med. 1989 Feb; 150(2):187-94. PMID: 2658327; PMCID: PMC1026332.
    639. Hubbard RC, Casolaro MA, Mitchell M, Sellers SE, Arabia F, Matthay M, Crystal RG. Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. Proc Natl Acad Sci U S A. 1989 Jan; 86(2):680-4. PMID: 2783491; PMCID: PMC286537.
    640. Matthay M, Chatterjee K. Bedside catheterization of the pulmonary artery: risks compared with benefits. Ann Intern Med. 1988 Nov 15; 109(10):826-34. PMID: 3056159.
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    641. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay M, Staub NC. Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. J Clin Invest. 1988 Oct; 82(4):1422-9. PMID: 3170750; PMCID: PMC442700.
    642. Murray JF, Matthay M, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988 Sep; 138(3):720-3. PMID: 3202424.
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    643. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay M. Alveolar liquid and protein clearance from normal dog lungs. J Appl Physiol (1985). 1988 Aug; 65(2):585-93. PMID: 3170409.
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    644. Aberle DR, Wiener-Kronish JP, Webb WR, Matthay M. Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients. Radiology. 1988 Jul; 168(1):73-9. PMID: 3380985.
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    645. Ratnoff WD, Matthay M, Wong MY, Ito Y, Vu KH, Wiener-Kronish J, Goetzl EJ. Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome. J Clin Immunol. 1988 Jul; 8(4):250-8. PMID: 2842367.
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    646. Wiener-Kronish JP, Matthay M. Pleural effusions associated with hydrostatic and increased permeability pulmonary edema. Chest. 1988 Apr; 93(4):852-8. PMID: 3349844.
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    647. Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay M. Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension. Chest. 1987 Dec; 92(6):967-70. PMID: 3677841.
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    648. Dean NC, Amend WC, Matthay M. Adult respiratory distress syndrome related to antilymphocyte globulin therapy. Chest. 1987 Apr; 91(4):619-20. PMID: 3549177.
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    649. Berthiaume Y, Staub NC, Matthay M. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J Clin Invest. 1987 Feb; 79(2):335-43. PMID: 2879851; PMCID: PMC424066.
    650. Biondi JW, Hines RL, Barash PG, Baker CC, Matthay MA, Matthay M. The adult respiratory distress syndrome. Yale J Biol Med. 1986 Nov-Dec; 59(6):575-97. PMID: 3538681; PMCID: PMC2590207.
    651. Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay M, Stulbarg MS. Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction. Chest. 1986 Sep; 90(3):455-7. PMID: 3743166.
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    652. Gates LM, Matthay M. Central intravascular pressure measurements: when should we believe them? J Thorac Imaging. 1986 Jul; 1(3):52-9. PMID: 3298681.
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    653. Fein A, Wiener-Kronish JP, Niederman M, Matthay M. Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies? Crit Care Clin. 1986 Jul; 2(3):429-53. PMID: 3331557.
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    654. Hansen RM, Viquerat CE, Matthay M, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K. Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Anesthesiology. 1986 Jun; 64(6):764-70. PMID: 3487261.
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    655. Bigby TD, Serota ML, Tierney LM, Matthay M. Clinical spectrum of pulmonary mucormycosis. Chest. 1986 Mar; 89(3):435-9. PMID: 3081299.
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    656. Broaddus C, Matthay M. Pulmonary embolism. Guide to diagnosis, treatment, and prevention. Postgrad Med. 1986 Mar; 79(4):333-7, 340-3. PMID: 3952050.
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    657. Swerdlow BN, Mihm FG, Goetzl EJ, Matthay M. Leukotrienes in pulmonary edema fluid after cardiopulmonary bypass. Anesth Analg. 1986 Mar; 65(3):306-8. PMID: 3006549.
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    658. Eisendrath SJ, Link N, Matthay M. Intensive care unit: how stressful for physicians? Crit Care Med. 1986 Feb; 14(2):95-8. PMID: 3943330.
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    659. Wiener-Kronish JP, Matthay M, Callen PW, Filly RA, Gamsu G, Staub NC. Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure. Am Rev Respir Dis. 1985 Dec; 132(6):1253-6. PMID: 3907444.
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    660. Matthay M. Cellular basis for injury and repair in the adult respiratory distress syndrome. West J Med. 1985 Nov; 143(5):665-7. PMID: 3909644; PMCID: PMC1306449.
    661. Matthay M. Pathophysiology of pulmonary edema. Clin Chest Med. 1985 Sep; 6(3):301-14. PMID: 3907942.
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    662. Matthay M. Resolution of pulmonary edema. Mechanisms of liquid, protein, and cellular clearance from the lung. Clin Chest Med. 1985 Sep; 6(3):521-45. PMID: 3907951.
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    663. Matthay M, Berthiaume Y, Staub NC. Long-term clearance of liquid and protein from the lungs of unanesthetized sheep. J Appl Physiol (1985). 1985 Sep; 59(3):928-34. PMID: 4055578.
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    664. Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay M. Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Am Heart J. 1985 Aug; 110(2):335-41. PMID: 3875274.
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    665. Matthay M, Eschenbacher WL, Goetzl EJ. Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. J Clin Immunol. 1984 Nov; 4(6):479-83. PMID: 6511865.
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    666. Colice GL, Matthay MA, Bass E, Matthay M. Neurogenic pulmonary edema. Am Rev Respir Dis. 1984 Nov; 130(5):941-8. PMID: 6388446.
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    667. Weinberg PF, Matthay M, Webster RO, Roskos KV, Goldstein IM, Murray JF. Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Respir Dis. 1984 Nov; 130(5):791-6. PMID: 6497161.
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    668. Bongard FS, Matthay M, Mackersie RC, Lewis FR. Morphologic and physiologic correlates of increased extravascular lung water. Surgery. 1984 Aug; 96(2):395-403. PMID: 6463867.
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    669. Wiedemann HP, Matthay MA, Matthay M. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 2). Chest. 1984 May; 85(5):656-68. PMID: 6713975.
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    670. Wiedemann HP, Matthay MA, Matthay M. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 1). Chest. 1984 Apr; 85(4):537-49. PMID: 6368142.
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    671. Prewitt RM, Matthay M, Ghignone M. Hemodynamic management in the adult respiratory distress syndrome. Clin Chest Med. 1983 May; 4(2):251-68. PMID: 6342923.
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    672. Matthay M. Invasive hemodynamic monitoring in critically ill patients. Clin Chest Med. 1983 May; 4(2):233-49. PMID: 6342922.
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    673. Eisendrath SJ, Matthay M, Dunkel JA, Zimmerman JK, Layzer RB. Guillain-Barré syndrome: psychosocial aspects of management. Psychosomatics. 1983 May; 24(5):465-75. PMID: 6878601.
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    674. Landolt CC, Matthay M, Albertine KH, Roos PJ, Wiener-Kronish JP, Staub NC. Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep. Circ Res. 1983 Mar; 52(3):335-41. PMID: 6825224.
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    675. Matthay M, Landolt CC, Staub NC. Differential liquid and protein clearance from the alveoli of anesthetized sheep. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul; 53(1):96-104. PMID: 7118651.
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    676. Russell J, Follansbee S, Matthay M. Adult respiratory distress syndrome complicating diabetic ketoacidosis. West J Med. 1981 Aug; 135(2):148-50. PMID: 6792789; PMCID: PMC1273047.
    677. Landolt CC, Matthay M, Staub NC. Anatomic variations of efferent duct from caudal mediastinal lymph node in sheep. J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun; 50(6):1372-4. PMID: 7263401.
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    678. Matthay M, Addison TE, Ellinger G, Choy SH, Kaltreider HB. Chest mass with pleurisy. Chest. 1979 Oct; 76(4):453-4. PMID: 477435.
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    679. Zwillich CW, Matthay M, Potts DE, Adler R, Hofeldt F, Weil JV. Thyrotoxicosis: comparison of effects of thyroid ablation and beta-adrenergic blockade on metabolic rate and ventilatory control. J Clin Endocrinol Metab. 1978 Mar; 46(3):491-500. PMID: 221522.
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    680. Matthay M, Lindamood M, Steigerwald JC, Solomons C. Acute pseudogout in the absence of synovial fluid Leukocytes. J Rheumatol. 1977; 4(3):303-6. PMID: 926107.
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    681. Matthay M, Matthay RA, Mills DM, Lakshminarayan S, Cotton E. Hypertrophic osteoarthropathy in adults with cystic fibrosis. Thorax. 1976 Oct; 31(5):572-5. PMID: 996819; PMCID: PMC470477.
    682. Matthay RA, Matthay M, Weinberger MM. Grand mal seizure induced by oral theophylline. Thorax. 1976 Aug; 31(4):470-1. PMID: 823660; PMCID: PMC470462.
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