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Michael Matthay, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-353-1206
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B.1969English
    University of PennsylvaniaM.D.1973School of Medicine
    University of Colorado Medical CenterInternship and Residency1976Internal Medicine
    University of California, San FranciscoFellowship1978Pulmonary DIvision
    University of California, San FranciscoFellowship1979Cardiovascular Research Institute

    Collapse Overview 
    Collapse Overview
    Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    1/1: ARREST RESPIRATORY FAILURE DUE TO PNEUMONIA (ARREST PNEUMONIA)
    NIH/NHLBI UG3HL141722Sep 23, 2019 - Aug 31, 2024
    Role: Co-Principal Investigator
    Prevention and Early Treatment of Acute Lung Injury
    NIH/NHLBI U01HL123004Jun 17, 2014 - Apr 30, 2021
    Role: Principal Investigator
    Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury
    NIH/NHLBI U01HL108713Sep 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH N01HR56166-16-0-1Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH N01HR56166-16-0-4Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - ALTA Protocol
    NIH/NHLBI N01HR56166Sep 30, 2005 - Sep 29, 2012
    Role: Co-Principal Investigator
    ARDS - EDEN Protocol
    NIH/NHLBI N01HR56166-6-0-3Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-7-0-1Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-9-0-1Sep 30, 2005 - Nov 30, 2011
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH/NHLBI P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    SCCOR in translational research in Acute Lung Injury
    NIH/NHLBI P50HL074005Sep 30, 2003 - Jun 30, 2010
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Resolution of Clinical Lung Injury
    NIH/NHLBI R37HL051856Apr 1, 1996 - Mar 31, 2016
    Role: Principal Investigator
    RESOLUTION OF CLINICAL LUNG INJURY
    NIH/NHLBI R01HL051856Apr 1, 1996 - Mar 31, 2006
    Role: Principal Investigator
    CCTG CLINICAL NETWORK FOR ARDS TREATMENT--CRITICAL CARE
    NIH/NHLBI N01HR046059Sep 30, 1994 - Dec 31, 2003
    Role: Principal Investigator
    Lung Fluid Balance and Mesenchymal Stem Cells
    NIH/NHLBI R01HL051854Apr 8, 1994 - Jun 30, 2013
    Role: Principal Investigator
    ALVEOLAR EPITHELIAL LIQUID AND PROTEIN CLEARANCE
    NIH/NHLBI R01HL040626Jun 1, 1988 - Nov 30, 1989
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PATHOPHYSIOLOGY OF LUNG LIQUID &PROTEIN EXCHANGE
    NIH P01HL025816Jun 1, 1980 - May 31, 1994
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Rogers AJ, Desai M, Matthay MA, Choi AM, Baron RM. The authors reply. Crit Care Med. 2020 Jan; 48(1):e78. PMID: 31833991.
      View in: PubMed
    2. Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD. Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Crit Care. 2019 12 09; 23(1):400. PMID: 31818332.
      View in: PubMed
    3. Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN. Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Crit Care Med. 2019 Dec 03. PMID: 31794436.
      View in: PubMed
    4. Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD. The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury. PLoS One. 2019; 14(11):e0225601. PMID: 31770424.
      View in: PubMed
    5. Liu A, Park JH, Zhang X, Sugita S, Naito Y, Lee JH, Kato H, Hao Q, Matthay MA, Lee JW. Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in Ex Vivo Perfused Human Lungs. Am J Respir Crit Care Med. 2019 Nov 15; 200(10):1234-1245. PMID: 31390880.
      View in: PubMed
    6. Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. Peripheral Blood Leukocyte Telomere Length is Associated with Survival of Sepsis Patients. Eur Respir J. 2019 Oct 16. PMID: 31619475.
      View in: PubMed
    7. Abreu SC, Rolandsson Enes S, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ. Lung inflammatory environments differentially alter mesenchymal stromal cell behavior. Am J Physiol Lung Cell Mol Physiol. 2019 Dec 01; 317(6):L823-L831. PMID: 31553626.
      View in: PubMed
    8. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 01; 317(5):L717-L736. PMID: 31509438.
      View in: PubMed
    9. Hanudel MR, Zinter MS, Chen L, Gala K, Lim M, Guglielmo M, Deshmukh T, Vangala S, Matthay M, Sapru A. Plasma total fibroblast growth factor 23 levels are associated with acute kidney injury and mortality in children with acute respiratory distress syndrome. PLoS One. 2019; 14(9):e0222065. PMID: 31487315.
      View in: PubMed
    10. Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie JD, Meyer NJ. Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. Am J Respir Crit Care Med. 2019 Sep 05. PMID: 31487195.
      View in: PubMed
    11. White DB, Carson S, Anderson W, Steingrub J, Bird G, Curtis JR, Matthay M, Peterson M, Buddadhumaruk P, Shields AM, Ernecoff N, Shotsberger K, Weissfeld L, Chang CH, Pike F, Lo B, Hough CL. A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs. Crit Care Med. 2019 Sep; 47(9):1184-1193. PMID: 31162200.
      View in: PubMed
    12. Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM. Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome. Crit Care Med. 2019 Aug; 47(8):1089-1096. PMID: 31206358.
      View in: PubMed
    13. Niemann CU, Matthay MA, Ware LB. The Continued Need for Clinical Trials in Deceased Organ Donor Management. Transplantation. 2019 Jul; 103(7):1298-1299. PMID: 30399123.
      View in: PubMed
    14. Ross JT, Nesseler N, Lee JW, Ware LB, Matthay MA. The ex vivo human lung: research value for translational science. JCI Insight. 2019 Jun 06; 4(11). PMID: 31167972.
      View in: PubMed
    15. Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA. Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction. Respir Care. 2019 Sep; 64(9):1101-1108. PMID: 31138736.
      View in: PubMed
    16. Huppert LA, Matthay MA, Ware LB. Pathogenesis of Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med. 2019 02; 40(1):31-39. PMID: 31060086.
      View in: PubMed
    17. Lee JW, Matthay MA. Is a Part Better than the Whole for Cell-based Therapy for Acute Respiratory Distress Syndrome? Anesthesiology. 2019 May; 130(5):683-685. PMID: 30870157.
      View in: PubMed
    18. Flori H, Sapru A, Quasney MW, Gildengorin G, Curley MAQ, Matthay MA, Dahmer MK. A prospective investigation of interleukin-8 levels in pediatric acute respiratory failure and acute respiratory distress syndrome. Crit Care. 2019 04 17; 23(1):128. PMID: 30995942.
      View in: PubMed
    19. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 Apr; 7(4):e14. PMID: 30926051.
      View in: PubMed
    20. Fielding-Singh V, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2019 Apr; 47(4):e375-e376. PMID: 30882440.
      View in: PubMed
    21. Fielding-Singh V, Matthay MA, Calfee CS. The authors reply. Crit Care Med. 2019 Apr; 47(4):e380-e381. PMID: 30882446.
      View in: PubMed
    22. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 04; 20(4):323-331. PMID: 30672838.
      View in: PubMed
    23. Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM. Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy. Am J Respir Crit Care Med. 2019 Apr 01; 199(7):863-872. PMID: 30334632.
      View in: PubMed
    24. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019 03 14; 5(1):18. PMID: 30872586.
      View in: PubMed
    25. Leligdowicz A, Matthay MA. Heterogeneity in sepsis: new biological evidence with clinical applications. Crit Care. 2019 Mar 09; 23(1):80. PMID: 30850013.
      View in: PubMed
    26. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M. Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Ann Am Thorac Soc. 2019 03; 16(3):356-362. PMID: 30407869.
      View in: PubMed
    27. Leligdowicz A, Matthay MA. AIMing Immunomodulation Therapy at Sepsis. Am J Respir Cell Mol Biol. 2019 Mar; 60(3):253-254. PMID: 30365342.
      View in: PubMed
    28. Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH. Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2019 02 01; 199(3):333-341. PMID: 30211618.
      View in: PubMed
    29. Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A. Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2019 01 15; 199(2):181-189. PMID: 30114376.
      View in: PubMed
    30. Matthay MA. ECMO in severe acute respiratory distress syndrome. Lancet Respir Med. 2019 Feb; 7(2):106-108. PMID: 30642777.
      View in: PubMed
    31. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB. Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. Am J Respir Crit Care Med. 2019 01 01; 199(1):62-70. PMID: 30067389.
      View in: PubMed
    32. Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA. Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2018 Dec; 19(12):e643-e652. PMID: 30277896.
      View in: PubMed
    33. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL. Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12353-E12362. PMID: 30482864.
      View in: PubMed
    34. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019 Feb; 7(2):154-162. PMID: 30455077.
      View in: PubMed
    35. Fielding-Singh V, Matthay MA, Calfee CS. Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome. Crit Care Med. 2018 11; 46(11):1820-1831. PMID: 30247273.
      View in: PubMed
    36. Huppert LA, Liu KD, Matthay MA. Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS. Transfusion. 2019 02; 59(S1):869-875. PMID: 30383290.
      View in: PubMed
    37. Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ. Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive Care Med. 2018 Nov; 44(11):1849-1858. PMID: 30343317.
      View in: PubMed
    38. Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS. Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study. Intensive Care Med. 2018 Nov; 44(11):1859-1869. PMID: 30291376.
      View in: PubMed
    39. Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H. Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure. Pediatr Crit Care Med. 2018 10; 19(10):930-938. PMID: 30095747.
      View in: PubMed
    40. Mi MY, Matthay MA, Morris AH. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N Engl J Med. 2018 08 30; 379(9):884-887. PMID: 30157406.
      View in: PubMed
    41. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 11; 27(Suppl 1):s20-s25. PMID: 30158203.
      View in: PubMed
    42. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. Possible hepatotoxicity of IQOS. Tob Control. 2018 11; 27(Suppl 1):s39-s40. PMID: 30131373.
      View in: PubMed
    43. Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL. Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury. Front Immunol. 2018; 9:1898. PMID: 30177934.
      View in: PubMed
    44. Park J, Kim S, Lim H, Liu A, Hu S, Lee J, Zhuo H, Hao Q, Matthay MA, Lee JW. Therapeutic effects of human mesenchymal stem cell microvesicles in an ex vivo perfused human lung injured with severe E. coli pneumonia. Thorax. 2019 01; 74(1):43-50. PMID: 30076187.
      View in: PubMed
    45. Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018 09; 6(9):691-698. PMID: 30078618.
      View in: PubMed
    46. Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD. Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Can J Kidney Health Dis. 2018; 5:2054358118789158. PMID: 30116543.
      View in: PubMed
    47. Schwede M, Wilfong EM, Zemans RL, Lee PJ, Dos Santos C, Fang X, Matthay MA. Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-a, IL-1ß, and IFN-?. Physiol Rep. 2018 08; 6(16):e13831. PMID: 30136410.
      View in: PubMed
    48. Kallet RH, Ho K, Lipnick MS, Matthay MA. Pulmonary mechanics and gas exchange characteristics in uncommon etiologies of acute respiratory distress syndrome. J Thorac Dis. 2018 Aug; 10(8):5030-5038. PMID: 30233877.
      View in: PubMed
    49. Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS. Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data. Intensive Care Med. 2018 Sep; 44(9):1388-1399. PMID: 30051136.
      View in: PubMed
    50. Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA. Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. Am J Physiol Lung Cell Mol Physiol. 2018 11 01; 315(5):L638-L644. PMID: 30024307.
      View in: PubMed
    51. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. PMID: 29999500.
      View in: PubMed
    52. Pais FM, Sinha P, Liu KD, Matthay MA. Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials. Respir Care. 2018 08; 63(8):1060-1069. PMID: 29991643.
      View in: PubMed
    53. Ross JT, Matthay MA, Harris HW. Secondary peritonitis: principles of diagnosis and intervention. BMJ. 2018 06 18; 361:k1407. PMID: 29914871.
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    54. Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax. 2018 09; 73(9):840-846. PMID: 29903755.
      View in: PubMed
    55. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Crit Care Med. 2018 04; 46(4):577-585. PMID: 29300236.
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    56. Hendrickson CM, Matthay MA. Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS. Pulm Circ. 2018 Apr-Jun; 8(2):2045894018769876. PMID: 29575977.
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    57. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40. PMID: 29543040.
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    58. Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD. Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution. Am J Med Qual. 2018 May/Jun; 33(3):329. PMID: 29473421.
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    59. Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay MA, Kukreja J. Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction. Clin Transplant. 2018 04; 32(4):e13210. PMID: 29377268.
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    60. Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S. Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. J Trauma Acute Care Surg. 2018 02; 84(2):245-256. PMID: 29251710.
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    61. Gotts JE, Matthay MA. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 02 01; 197(3):280-281. PMID: 29072926.
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    62. Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA. Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System. Am J Crit Care. 2018 01; 27(1):43-50. PMID: 29292274.
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    63. Matthay MA, Abman SH. Exosome-based Therapy for Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2018 01 01; 197(1):10-12. PMID: 28957642.
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    64. Fang X, Matthay MA. Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions. Methods Mol Biol. 2018; 1809:121-128. PMID: 29987787.
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    65. Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay MA, Reynolds T. Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania. Front Pediatr. 2017; 5:278. PMID: 29312910.
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    66. Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Am J Respir Cell Mol Biol. 2017 12; 57(6):711-720. PMID: 28708422.
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    67. Matthay MA. Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury. Basic Science and Clinical Implications. Am J Respir Crit Care Med. 2017 11 15; 196(10):1234-1236. PMID: 28640648.
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    68. Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A. Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats. J Heart Lung Transplant. 2018 06; 37(6):782-791. PMID: 29229270.
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    69. Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA, Hertz T, Randolph AG. Cytokine Profiles of Severe Influenza Virus-Related Complications in Children. Front Immunol. 2017; 8:1423. PMID: 29163498.
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    70. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 11 01; 313(5):L966-L967. PMID: 29109110.
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    75. Crouser ED, Matthay MA. Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies. Chest. 2017 07; 152(1):1-3. PMID: 28693760.
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    77. Schell-Chaple HM, Liu KD, Matthay MA, Sessler DI, Puntillo KA. Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Crit Care Med. 2017 Jul; 45(7):1199-1207. PMID: 28319467.
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    82. McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay MA, O'Kane CM. Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Respir Med. 2017 06; 5(6):484-491. PMID: 28526233.
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    86. Huppert LA, Matthay MA. Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome. Front Immunol. 2017; 8:371. PMID: 28439268.
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    90. Matthay MA, Pati S, Lee JW. Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis. Stem Cells. 2017 02; 35(2):316-324. PMID: 27888550.
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    94. Moore PK, Matthay MA. Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful? JAMA Intern Med. 2016 11 01; 176(11):1660-1661. PMID: 27599363.
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    101. Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay MA, Thompson BT, Bajwa EK. Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Sep; 44(9):1735-43. PMID: 27525994.
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    123. Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW. Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):324-36. PMID: 26067592.
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    150. Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS. Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Am J Transplant. 2014 Oct; 14(10):2295-302. PMID: 25146497.
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    155. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40. PMID: 25960880.
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    156. Sakuma T, Matthay MA. Translational studies in the ex vivo human lung. Respir Investig. 2014 Jul; 52(4):219-20. PMID: 24998367.
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    157. Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM. Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1520-9. PMID: 24716610.
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    159. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax. 2014 Sep; 69(9):819-25. PMID: 24891325.
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    163. Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 05; 370(23):2191-200. PMID: 24835849.
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    164. Wilson JG, Matthay MA. Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist. J Hosp Med. 2014 Jul; 9(7):469-75. PMID: 24733692.
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    165. Rogers AJ, Matthay MA. Applying metabolomics to uncover novel biology in ARDS. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 01; 306(11):L957-61. PMID: 24727586.
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    166. Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C. Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 01; 306(11):L975-85. PMID: 24682451.
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    167. Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA. A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Am J Transplant. 2014 Mar; 14(3):621-8. PMID: 24730050.
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    168. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB. Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care. 2014 Feb 18; 4(1):4. PMID: 24533450.
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    169. McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott J, McKenna DH, Fang X, Matthay MA, Lee JW. Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. Am J Physiol Lung Cell Mol Physiol. 2014 May 01; 306(9):L809-15. PMID: 24532289.
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    170. Liles WC, Matthay MA, Dos Santos CC, Weiss DJ, Stewart DJ. Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):363-4. PMID: 24484339.
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    171. Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One. 2014; 9(1):e87538. PMID: 24498130.
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    172. Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M. Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1560-5. PMID: 24534681.
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    173. Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN. One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive Care Med. 2014 Mar; 40(3):388-96. PMID: 24435201.
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    174. Frank JA, Matthay MA. TGF-ß and lung fluid balance in ARDS. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):885-6. PMID: 24449829.
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    175. Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee JW. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells. 2014 Jan; 32(1):116-25. PMID: 23939814.
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    176. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA. The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Respir Care. 2014 Nov; 59(11):1611-8. PMID: 24381187.
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    177. Gotts JE, Matthay MA. Treating ARDS: new hope for a tough problem. Lancet Respir Med. 2014 Feb; 2(2):84-5. PMID: 24503258.
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    178. Engel J, Matthay M. Cystic fibrosis epithelial cell and bacterial binding. Am J Physiol Lung Cell Mol Physiol. 2013 Dec; 305(11):L891. PMID: 24310120.
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    179. Bajwa EK, Volk JA, Christiani DC, Harris RS, Matthay MA, Thompson BT, Januzzi JL. Prognostic and diagnostic value of plasma soluble suppression of tumorigenicity-2 concentrations in acute respiratory distress syndrome. Crit Care Med. 2013 Nov; 41(11):2521-31. PMID: 23939353.
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    180. Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome. Crit Care. 2013 Oct 24; 17(5):R253. PMID: 24156650.
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    181. Hendrickson CM, Matthay MA. Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. Semin Respir Crit Care Med. 2013 Aug; 34(4):475-86. PMID: 23934716.
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    182. Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF. Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury. Ann Intensive Care. 2013 Aug 11; 3(1):25. PMID: 23937970.
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    183. Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA. Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*. Crit Care Med. 2013 Aug; 41(8):1929-37. PMID: 23782966.
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    184. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5. PMID: 23713908.
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    185. Glassberg MK, Hare JM, Toonkel RL, Matthay MA. Reply: idiopathic pulmonary fibrosis: a degenerative disease requiring a regenerative approach. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):253-4. PMID: 23855697.
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    186. Toonkel RL, Hare JM, Matthay MA, Glassberg MK. Mesenchymal stem cells and idiopathic pulmonary fibrosis. Potential for clinical testing. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):133-40. PMID: 23306542.
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    187. Bucior I, Abbott J, Song Y, Matthay MA, Engel JN. Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 2013 Sep; 305(5):L352-63. PMID: 23792737.
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    188. Gotts JE, Matthay MA. Cell therapy for lung disease: a step forward. Chest. 2013 Jun; 143(6):1525-1527. PMID: 23732575.
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    189. Matthay MA, Song Y, Bai C, Jones KD. The acute respiratory distress syndrome in 2013. Transl Respir Med. 2013 Dec; 1(1):10. PMID: 27234392.
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    190. Thompson BT, Matthay MA. The Berlin definition of ARDS versus pathological evidence of diffuse alveolar damage. Am J Respir Crit Care Med. 2013 Apr 01; 187(7):675-7. PMID: 23540876.
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    191. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May; 123(5):2037-48. PMID: 23543053.
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    192. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 01; 187(7):736-42. PMID: 23328529.
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    193. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med. 2013 Apr 01; 187(7):751-60. PMID: 23292883.
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    194. Seeley EJ, Barry SS, Narala S, Matthay MA, Wolters PJ. Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice. J Immunol. 2013 May 01; 190(9):4717-24. PMID: 23543756.
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    195. Seeley EJ, Rosenberg P, Matthay MA. Calcium flux and endothelial dysfunction during acute lung injury: a STIMulating target for therapy. J Clin Invest. 2013 Mar; 123(3):1015-8. PMID: 23434597.
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    196. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol. Trials. 2013 Feb 18; 14:51. PMID: 23419093.
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    197. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013 Feb 08; 18:1481-90. PMID: 23296426.
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    198. Howard M, Roux J, Iles KE, Miyazawa B, Christiaans S, Anjum N, Dickinson DA, Goolaerts A, Matthay MA, Pittet JF. Activation of the heat shock response attenuates the interleukin 1ß-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Shock. 2013 Feb; 39(2):189-96. PMID: 23324889.
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    199. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. PMID: 23357450.
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    200. Schultz MJ, Juffermans NP, Matthay MA. From protective ventilation to super-protective ventilation for acute respiratory distress syndrome. Intensive Care Med. 2013 May; 39(5):963-5. PMID: 23306587.
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    201. Bastarache JA, Matthay MA. Cecal ligation model of sepsis in mice: new insights. Crit Care Med. 2013 Jan; 41(1):356-7. PMID: 23269150.
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    202. Bhattacharya J, Matthay MA. Regulation and repair of the alveolar-capillary barrier in acute lung injury. Annu Rev Physiol. 2013; 75:593-615. PMID: 23398155.
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    203. Kallet RH, Matthay MA. Hyperoxic acute lung injury. Respir Care. 2013 Jan; 58(1):123-41. PMID: 23271823.
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    204. Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism. FASEB J. 2013 Mar; 27(3):1095-106. PMID: 23221335.
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    205. Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK. Novel aspects of urokinase function in the injured lung: role of a2-macroglobulin. Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15; 303(12):L1037-45. PMID: 23064953.
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    206. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L634-9. PMID: 22865551.
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    207. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest. 2012 Aug; 122(8):2731-40. PMID: 22850883.
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    208. Zeyed YF, Bastarache JA, Matthay MA, Ware LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15; 303(6):L550-5. PMID: 22821995.
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    209. Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS. Clinical evidence of early acute lung injury often precedes the diagnosis of ALI. J Intensive Care Med. 2013 Jul-Aug; 28(4):241-6. PMID: 22733725.
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    210. Levitt JE, Matthay MA. Clinical review: Early treatment of acute lung injury--paradigm shift toward prevention and treatment prior to respiratory failure. Crit Care. 2012 Jun 19; 16(3):223. PMID: 22713281.
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    211. Seeley EJ, Matthay MA, Wolters PJ. Inflection points in sepsis biology: from local defense to systemic organ injury. Am J Physiol Lung Cell Mol Physiol. 2012 Sep; 303(5):L355-63. PMID: 22707617.
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    212. Lee JW, Zhu Y, Matthay MA. Cell-based therapy for acute lung injury: are we there yet? Anesthesiology. 2012 Jun; 116(6):1189-91. PMID: 22531337.
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    213. Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA. Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med. 2012 Jun; 40(6):1731-7. PMID: 22610178.
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    214. Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T. Protein kinase C-a and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):445-53. PMID: 22582175.
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    215. Nazarov I, Lee JW, Soupene E, Etemad S, Knapik D, Green W, Bashkirova E, Fang X, Matthay MA, Kuypers FA, Serikov VB. Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential. Stem Cells Transl Med. 2012 May; 1(5):359-72. PMID: 23197815.
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    216. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9. PMID: 22561460.
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    217. Matthay MA, Howard JP. Progress in modelling acute lung injury in a pre-clinical mouse model. Eur Respir J. 2012 May; 39(5):1062-3. PMID: 22547731.
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    218. Gotts JE, Matthay MA. Mesenchymal stem cells and the stem cell niche: a new chapter. Am J Physiol Lung Cell Mol Physiol. 2012 Jun 01; 302(11):L1147-9. PMID: 22505672.
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    219. Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Am J Physiol Lung Cell Mol Physiol. 2012 May 15; 302(10):L1003-13. PMID: 22427530.
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    220. Cha SI, Chang CS, Kim EK, Lee JW, Matthay MA, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ. Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Histopathology. 2012 Jul; 61(1):98-106. PMID: 22394225.
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    221. Sapru A, Zaroff JG, Pawlikowska L, Liu KD, Khush KK, Baxter-Lowe LA, Hayden V, Menza RL, Convery M, Lo V, Poon A, Kim H, Young WL, Kukreja J, Matthay MA. The 4G/4G genotype of the PAI-1 (serpine-1) 4G/5G polymorphism is associated with decreased lung allograft utilization. Am J Transplant. 2012 Jul; 12(7):1848-54. PMID: 22390401.
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    222. Kallet RH, Alonso JA, Matthay MA. Quantifying the severity of acute lung injury using dead-space ventilation: should the lung injury score be updated? Respir Care. 2012 Mar; 57(3):477-9. PMID: 22391272.
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    223. Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA. Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors. Clin Transplant. 2012 Sep-Oct; 26(5):665-71. PMID: 22324977.
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    224. Bosmann M, Grailer JJ, Zhu K, Matthay MA, Sarma JV, Zetoune FS, Ward PA. Anti-inflammatory effects of ß2 adrenergic receptor agonists in experimental acute lung injury. FASEB J. 2012 May; 26(5):2137-44. PMID: 22318967.
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    225. Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One. 2012; 7(1):e28268. PMID: 22295056.
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    226. Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV. Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2084-9. PMID: 22308467.
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    227. Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, Matthay MA. Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Thorax. 2012 Jun; 67(6):533-9. PMID: 22250097.
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    228. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-1169. PMID: 22207676.
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    229. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med. 2011 Dec; 39(12):2665-71. PMID: 21785346.
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    230. Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W. A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Crit Care Med. 2011 Dec; 39(12):2645-51. PMID: 21725235.
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    231. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. PMID: 22117051.
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    232. Matthay MA, Kallet RH. Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome. Crit Care. 2011; 15(5):185. PMID: 22067424.
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    233. Mac Sweeney R, McAuley DF, Matthay MA. Acute lung failure. Semin Respir Crit Care Med. 2011 Oct; 32(5):607-25. PMID: 21989697.
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    234. Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT. Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 01; 184(5):561-8. PMID: 21562125.
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    235. Pitt BR, Christman JW, Gunst SJ, Matthay MA, Stevens T, Ware LB. Physiology, reductionism, and translational medicine: the right mix. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L389-90. PMID: 21856812.
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    236. Singer M, Matthay MA. Clinical review: Thinking outside the box--an iconoclastic view of current practice. Crit Care. 2011 Jul 26; 15(4):225. PMID: 21888690.
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    237. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol. 2011 Sep; 179(3):1081-7. PMID: 21741940.
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    238. Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA. Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care. 2011 Jun 14; 1(1):20. PMID: 21906362.
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    239. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu KD. Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Ann Intensive Care. 2011 Jun 13; 1(1):18. PMID: 21906356.
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    240. Lee JW, Fang X, Krasnodembskaya A, Howard JP, Matthay MA. Concise review: Mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells. 2011 Jun; 29(6):913-9. PMID: 21506195.
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    241. Flori HR, Church G, Liu KD, Gildengorin G, Matthay MA. Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract. 2011; 2011:854142. PMID: 21687578.
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    242. Gotts JE, Matthay MA. Mesenchymal stem cells and acute lung injury. Crit Care Clin. 2011 Jul; 27(3):719-33. PMID: 21742225.
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    243. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol. 2011 May; 44(5):725-38. PMID: 21531958.
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    244. Matthay MA, Liu KD. Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Am J Respir Crit Care Med. 2011 May 01; 183(9):1127-8. PMID: 21531953.
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    245. Seeley EJ, McAuley DF, Eisner M, Miletin M, Zhuo H, Matthay MA, Kallet RH. Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury. Respir Res. 2011 Apr 22; 12:52. PMID: 21513532.
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    246. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L71-8. PMID: 21498628.
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    247. Cross LJ, Matthay MA. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin. 2011 Apr; 27(2):355-77. PMID: 21440206.
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    248. Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA. Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med. 2011 Apr; 39(4):711-7. PMID: 21283009.
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    249. Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1660-5. PMID: 21471091.
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    250. Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay MA, Wright P, Ely EW. Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care. 2011; 15(2):R86. PMID: 21385351.
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    251. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011 Jul; 60(7):619-32. PMID: 21301926.
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    252. Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA. Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization. J Heart Lung Transplant. 2011 Feb; 30(2):211-7. PMID: 20869266.
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    253. Rey MM, Ware LB, Matthay MA, Bernard GR, McGuire AL, Caplan AL, Halpern SD. Informed consent in research to improve the number and quality of deceased donor organs. Crit Care Med. 2011 Feb; 39(2):280-3. PMID: 20975549.
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    254. Yamakawa N, Uchida T, Matthay MA, Makita K. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Apr; 300(4):L516-25. PMID: 21257730.
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    255. Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay MA, Mason R, Silver RF, Kern JA. Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. J Biol Chem. 2011 Mar 25; 286(12):10660-70. PMID: 21247898.
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    256. Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS. Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Crit Care Med. 2011 Jan; 39(1):40-5. PMID: 20935560.
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    257. Matthay MA, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 2011; 6:147-63. PMID: 20936936.
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    258. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010 Dec; 28(12):2229-38. PMID: 20945332.
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    259. Levitt JE, Matthay MA. The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition. Expert Rev Respir Med. 2010 Dec; 4(6):785-97. PMID: 21128753.
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    260. Cribbs SK, Matthay MA, Martin GS. Stem cells in sepsis and acute lung injury. Crit Care Med. 2010 Dec; 38(12):2379-85. PMID: 20838330.
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    261. Lee JS, Su X, Rackley C, Matthay MA, Gupta N. Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken). 2011 Jan; 294(1):165-72. PMID: 21157927.
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    262. Singer M, Matthay MA. Thinking outside the box: Introduction. Crit Care Med. 2010 Oct; 38(10 Suppl):S511. PMID: 21164389.
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    263. Matthay MA, Goolaerts A, Howard JP, Lee JW. Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med. 2010 Oct; 38(10 Suppl):S569-73. PMID: 21164399.
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    264. Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest. 2010 Oct; 138(4):965-72. PMID: 20923800.
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    265. Brown LM, Kallet RH, Matthay MA, Dicker RA. The influence of race on the development of acute lung injury in trauma patients. Am J Surg. 2011 Apr; 201(4):486-91. PMID: 20832050.
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    266. Looney MR, Gilliss BM, Matthay MA. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. PMID: 20601870.
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    267. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med. 2010 Sep; 38(9):1845-51. PMID: 20581666.
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    268. McAuley DF, Brown LM, Matthay MA. Assessing the quantity of pulmonary edema in critically ill children. Crit Care. 2010; 14(4):189. PMID: 20804574.
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    269. Bastarache JA, Ong T, Matthay MA, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care. 2011 Jun; 26(3):249-56. PMID: 20688464.
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    270. Matthay MA. Advances and challenges in translating stem cell therapies for clinical diseases. Transl Res. 2010 Sep; 156(3):107-11. PMID: 20801407.
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    271. Diaz JV, Brower R, Calfee CS, Matthay MA. Therapeutic strategies for severe acute lung injury. Crit Care Med. 2010 Aug; 38(8):1644-50. PMID: 20562704.
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    272. Johnson ER, Matthay MA. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010 Aug; 23(4):243-52. PMID: 20073554.
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    273. Matthay MA, Jayr C. Acute respiratory distress syndrome after surgery: can the risk be decreased? Anesth Analg. 2010 Aug; 111(2):268-9. PMID: 20664090.
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    274. Fang X, Neyrinck AP, Matthay MA, Lee JW. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem. 2010 Aug 20; 285(34):26211-22. PMID: 20554518.
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    275. Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD. Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med. 2010 Jun; 38(6):1450-7. PMID: 20386308.
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    276. Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR. Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med. 2010 Jun; 38(6):1436-41. PMID: 20386309.
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    277. Matthay MA, Idell S. Update on acute lung injury and critical care medicine 2009. Am J Respir Crit Care Med. 2010 May 15; 181(10):1027-32. PMID: 20460547.
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    278. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010 May; 68(5):1121-7. PMID: 20038857.
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    279. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7. PMID: 20418386.
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    280. Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA. Regulated gene expression in cultured type II cells of adult human lung. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L36-50. PMID: 20382749.
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    281. Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF. Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. Thorax. 2010 Apr; 65(4):346-53. PMID: 20388761.
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    282. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay MA, DeLeo FR, Chambers HF. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. PMID: 20231457.
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    283. Calfee CS, Matthay MA. Clinical immunology: Culprits with evolutionary ties. Nature. 2010 Mar 04; 464(7285):41-2. PMID: 20203598.
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    284. Brown LM, Matthay MA. Measuring the quantity of pulmonary edema in clinical lung injury. Crit Care Med. 2010 Jan; 38(1):312-4. PMID: 20023478.
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    285. Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB. Thirty years of critical care medicine. Crit Care. 2010; 14(3):311. PMID: 20550727.
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    286. Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2010 Feb 12; 285(7):4278-90. PMID: 19996317.
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    287. Abman SH, Matthay MA. Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1039-41. PMID: 19923401.
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    288. Su X, Matthay MA, Malik AB. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol. 2010 Jan 01; 184(1):401-10. PMID: 19949071.
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    289. Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay MA, Hashimoto S. Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury. Intensive Care Med. 2010 Mar; 36(3):479-86. PMID: 19940975.
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    290. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay MA, Fineman JR, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. PMID: 19830720.
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    291. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay MA. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest. 2010 Feb; 137(2):288-96. PMID: 19858233.
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    292. Sapru A, Curley MA, Brady S, Matthay MA, Flori H. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med. 2010 Jan; 36(1):157-63. PMID: 19855955.
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    293. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
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    294. Lee JW, Gupta N, Serikov V, Matthay MA. Potential application of mesenchymal stem cells in acute lung injury. Expert Opin Biol Ther. 2009 Oct; 9(10):1259-70. PMID: 19691441.
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    295. Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur Respir J. 2010 Feb; 35(2):331-7. PMID: 19741024.
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    296. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62. PMID: 19721001.
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    297. Goolaerts A, Roux J, Ganter MT, Shlyonsky V, Chraibi A, Stéphane R, Mies F, Matthay MA, Naeije R, Sariban-Sohraby S, Howard M, Pittet JF. Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. Am J Respir Cell Mol Biol. 2010 Jul; 43(1):99-108. PMID: 19717814.
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    298. Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay MA, Martin TR. Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure. Crit Care. 2009; 13(4):R134. PMID: 19671148.
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    299. Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C. NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med. 2009 Nov 15; 180(10):972-81. PMID: 19661248.
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    300. Brown LM, Liu KD, Matthay MA. Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L547-58. PMID: 19617309.
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    301. McAuley DF, Matthay MA. Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury. Chest. 2009 Jun; 135(6):1408-1410. PMID: 19497890.
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    302. Liu KD, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. PMID: 19519935.
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    303. Neyrinck AP, Liu KD, Howard JP, Matthay MA. Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol. 2009 Oct; 158(4):1034-47. PMID: 19466992.
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    304. Church GD, Matthay MA, Liu K, Milet M, Flori HR. Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Pediatr Crit Care Med. 2009 May; 10(3):297-302. PMID: 19307809.
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    305. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol. 2009 May; 44(5):457-63. PMID: 19382217.
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    306. Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology. 2009 May; 110(5):1086-91. PMID: 19387177.
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    307. Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309.
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    308. Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD. Recent trends in acute lung injury mortality: 1996-2005. Crit Care Med. 2009 May; 37(5):1574-9. PMID: 19325464.
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    309. Su X, Matthay MA. Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis. Anat Rec (Hoboken). 2009 Apr; 292(4):580-6. PMID: 19226616.
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    310. Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1107-14. PMID: 19324974.
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    311. Levitt JE, Gould MK, Ware LB, Matthay MA. The pathogenetic and prognostic value of biologic markers in acute lung injury. J Intensive Care Med. 2009 May-Jun; 24(3):151-67. PMID: 19282296.
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    312. Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA. Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure. Chest. 2009 Apr; 135(4):936-943. PMID: 19188549.
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    313. Neyrinck AP, Matthay MA. The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats. Crit Care Med. 2009 Feb; 37(2):776-7. PMID: 19325385.
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    314. Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay MA, Eisner MD. Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med. 2009 Jan; 37(1):1-6. PMID: 19050621.
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    315. Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay MA, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK. Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):155-69. PMID: 19109244.
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    316. Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay MA, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2009 Apr 01; 46(7):866-75. PMID: 19133325.
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    317. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-275. PMID: 19017890.
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    318. Ware LB, Matthay MA. Beyond fishing: the role of discovery proteomics in mechanistic lung research. Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L12-3. PMID: 19011049.
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    319. Looney MR, Esmon CT, Matthay MA. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20. PMID: 19008297.
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    320. Glassberg AE, Luce JM, Matthay MA. Reasons for nonenrollment in a clinical trial of acute lung injury. Chest. 2008 Oct; 134(4):719-23. PMID: 18689583.
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    321. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med. 2009 Feb; 35(2):248-57. PMID: 18670758.
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    322. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23. PMID: 18565951.
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    323. Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax. 2008 Dec; 63(12):1083-9. PMID: 18566109.
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    324. Seeley E, McAuley DF, Eisner M, Miletin M, Matthay MA, Kallet RH. Predictors of mortality in acute lung injury during the era of lung protective ventilation. Thorax. 2008 Nov; 63(11):994-8. PMID: 18566110.
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    325. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. PMID: 18496381.
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    326. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. PMID: 18453616.
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    327. Matthay MA, Berthiaume Y. Novel molecular strategy to prevent pulmonary edema. Crit Care Med. 2008 May; 36(5):1671-3. PMID: 18448936.
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    328. Matthay MA. Measurement of extravascular lung water in patients with pulmonary edema. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1021-2. PMID: 18441090.
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    329. Liu KD, Matthay MA. Protein C as a surrogate end-point for clinical trials of sepsis. Crit Care. 2008; 12(2):139. PMID: 18492215.
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    330. Matthay MA. Treatment of acute lung injury: clinical and experimental studies. Proc Am Thorac Soc. 2008 Apr 15; 5(3):297-9. PMID: 18403322.
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    331. Matthay MA, Calfee CS. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest. 2008 Apr; 133(4):833-5. PMID: 18398109.
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    332. McClintock D, Zhuo H, Wickersham N, Matthay MA, Ware LB. Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit Care. 2008; 12(2):R41. PMID: 18358078.
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    333. Matthay MA, Lee J. Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Thorax. 2008 Mar; 63(3):189-90. PMID: 18308954.
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    334. Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L874-81. PMID: 18310227.
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    335. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. PMID: 18276918.
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    336. Liu KD, Matthay MA. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clin J Am Soc Nephrol. 2008 Mar; 3(2):578-86. PMID: 18199848.
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    337. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol. 2008 Jan 01; 180(1):637-46. PMID: 18097066.
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    338. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007 Dec; 35(12):2755-61. PMID: 18074478.
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    339. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007 Oct; 35(10):2243-50. PMID: 17944012.
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    340. Looney MR, Matthay MA. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. PMID: 24395479.
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    341. Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay MA. Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50. PMID: 17630877.
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    342. Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008 Feb; 63(2):147-53. PMID: 17901159.
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    343. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. PMID: 17804488.
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    344. Matthay MA, Taeusch W. Surfactant treatment of aspiration-induced lung injury in children. Pediatr Crit Care Med. 2007 Sep; 8(5):505-6. PMID: 17873790.
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    345. Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay MA. Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken). 2007 Sep; 290(9):1033-45. PMID: 17661377.
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    346. Ware LB, Matthay MA, Parsons PE, Thompson BT, Januzzi JL, Eisner MD. Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med. 2007 Aug; 35(8):1821-8. PMID: 17667242.
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    347. Pauluhn J, Carson A, Costa DL, Gordon T, Kodavanti U, Last JA, Matthay MA, Pinkerton KE, Sciuto AM. Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Inhal Toxicol. 2007 Aug; 19(10):789-810. PMID: 17687713.
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    348. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J Immunol. 2007 Aug 01; 179(3):1855-63. PMID: 17641052.
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    349. Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant. 2007 Jul; 26(7):675-80. PMID: 17613396.
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    350. Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA, Ware LB, Matthay MA. Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J Biol Chem. 2007 Aug 17; 282(33):24109-19. PMID: 17580309.
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    351. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA. Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest. 2007 Sep; 132(3):836-42. PMID: 17573490.
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    352. Berthiaume Y, Matthay MA. Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol. 2007 Dec 15; 159(3):350-9. PMID: 17604701.
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    353. Fudala R, Krupa A, Matthay MA, Allen TC, Kurdowska AK. Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. Am J Physiol Lung Cell Mol Physiol. 2007 Aug; 293(2):L364-74. PMID: 17513455.
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    354. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007 May; 245(5):812-8. PMID: 17457176.
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    355. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51. PMID: 17468134.
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    356. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):186-92. PMID: 17431097.
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    357. Fremont RD, Kallet RH, Matthay MA, Ware LB. Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest. 2007 Jun; 131(6):1742-6. PMID: 17413051.
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    358. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. PMID: 17363773.
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    359. Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax. 2007 Jul; 62(7):608-16. PMID: 17356058.
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    360. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L52-9. PMID: 17351061.
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    361. Calfee CS, Matthay MA. Nonventilatory treatments for acute lung injury and ARDS. Chest. 2007 Mar; 131(3):913-920. PMID: 17356114.
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    362. Flori HR, Ware LB, Milet M, Matthay MA. Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2007 Mar; 8(2):96-101. PMID: 17273112.
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    363. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496.
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    364. Frank JA, Parsons PE, Matthay MA. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14. PMID: 17167015.
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    365. Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay MA. Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome. Clin Chest Med. 2006 Dec; 27(4):627-35; abstract ix. PMID: 17085251.
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    366. Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):480-90. PMID: 17099140.
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    367. Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):497-503. PMID: 17099142.
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    368. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov; 12(11):1286-93. PMID: 17086189.
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    369. McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay MA. Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med. 2007 Feb 01; 175(3):256-62. PMID: 17082495.
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    370. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. PMID: 17079779.
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    371. Lee JW, Matthay MA. Protein permeability in lung injury: now in real time again? J Appl Physiol (1985). 2007 Feb; 102(2):508-9. PMID: 17068211.
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    372. Levitt JE, Matthay MA. Treatment of acute lung injury: historical perspective and potential future therapies. Semin Respir Crit Care Med. 2006 Aug; 27(4):426-37. PMID: 16909376.
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    373. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1191-8. PMID: 16877636.
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    374. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. FASEB J. 2006 Jul; 20(9):1519-21. PMID: 16793871.
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    375. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay MA. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 2006 Sep; 32(9):1293-303. PMID: 16770611.
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    376. Gupta N, Matthay MA. Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7. PMID: 16714999.
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    377. Wiener-Kronish JP, Matthay MA. Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury. Crit Care Med. 2006 Jun; 34(6):1841-2. PMID: 16714996.
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    378. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475.
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    379. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14. PMID: 16710477.
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    380. McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay MA. Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L566-71. PMID: 16698854.
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    381. Liu KD, Matthay MA, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clin J Am Soc Nephrol. 2006 Jul; 1(4):869-73. PMID: 17699299.
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    382. Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay MA, Fleshner M, Pittet JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L354-61. PMID: 16679378.
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    383. Looney MR, Matthay MA. Animal models of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S132-6. PMID: 16617257.
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    384. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6. PMID: 16618787.
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    385. Cepkova M, Matthay MA. Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med. 2006 May-Jun; 21(3):119-43. PMID: 16672636.
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    386. Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA. Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L307-11. PMID: 16648240.
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    387. Matthay MA, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB. Perspectives, translational research, and letters to the editor. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L621. PMID: 16531563.
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    388. Folkesson HG, Matthay MA. Alveolar epithelial ion and fluid transport: recent progress. Am J Respir Cell Mol Biol. 2006 Jul; 35(1):10-9. PMID: 16514116.
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    389. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay MA, Hibberd PL. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7. PMID: 16616620.
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    390. Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay MA. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med. 2006 Mar; 34(3):676-81. PMID: 16505652.
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    391. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay MA. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med. 2006 May 01; 173(9):1008-15. PMID: 16456142.
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    392. Matthay MA, Abraham E. Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med. 2006 Feb 01; 173(3):254-5. PMID: 16436367.
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    393. Looney MR, Matthay MA. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239. PMID: 17169139.
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    394. Cepkova M, Brady S, Sapru A, Matthay MA, Church G. Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury. Crit Care. 2006; 10(5):R126. PMID: 16956410.
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    395. Ware LB, Matthay MA. Clinical practice. Acute pulmonary edema. N Engl J Med. 2005 Dec 29; 353(26):2788-96. PMID: 16382065.
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    396. Su X, Robriquet L, Folkesson HG, Matthay MA. Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L769-L776. PMID: 16284214.
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    397. Matthay MA, Calfee CS. Therapeutic value of a lung protective ventilation strategy in acute lung injury. Chest. 2005 Nov; 128(5):3089-91. PMID: 16304246.
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    398. Matthay MA, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):319-27. PMID: 16172252.
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    399. Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay MA. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant. 2005 Oct; 24(10):1650-6. PMID: 16210143.
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    400. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay MA. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9. PMID: 16143588.
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    401. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. PMID: 16081834.
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    402. Frank JA, Matthay MA. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 01; 172(3):261-2. PMID: 16040787.
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    403. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37. PMID: 16014597.
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    404. Ware LB, Kaner RJ, Crystal RG, Schane R, Trivedi NN, McAuley D, Matthay MA. VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema. Eur Respir J. 2005 Jul; 26(1):101-5. PMID: 15994395.
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    405. Calfee CS, Matthay MA. Recent advances in mechanical ventilation. Am J Med. 2005 Jun; 118(6):584-91. PMID: 15922687.
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    406. Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):231-47. PMID: 15891109.
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    407. Kallet RH, Daniel BM, Garcia O, Matthay MA. Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method. Respir Care. 2005 Apr; 50(4):462-7. PMID: 15807908.
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    408. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L104-10. PMID: 15781423.
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    409. Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E. Critical care in AJRCCM 2004. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):537-44. PMID: 15753483.
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    410. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005 May 13; 280(19):18579-89. PMID: 15755725.
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    411. Parsons PE, Eisner MD, Thompson BT, Matthay MA, Ancukiewicz M, Bernard GR, Wheeler AP. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med. 2005 Jan; 33(1):1-6; discussion 230-2. PMID: 15644641.
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    412. Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay MA. Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Crit Care Med. 2005 Jan; 33(1):63-70; discussion 239-40. PMID: 15644650.
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    413. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. PMID: 15644667.
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    414. McAuley DF, Matthay MA. Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome? Treat Respir Med. 2005; 4(5):297-307. PMID: 16137187.
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    415. Matthay MA, Robriquet L, Fang X. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc Am Thorac Soc. 2005; 2(3):206-13. PMID: 16222039.
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    416. Flori HR, Glidden DV, Rutherford GW, Matthay MA. Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality. Am J Respir Crit Care Med. 2005 May 01; 171(9):995-1001. PMID: 15618461.
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    417. Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. FASEB J. 2005 Feb; 19(2):287-9. PMID: 15550551.
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    418. Matthay MA, Ware LB. Can nicotine treat sepsis? Nat Med. 2004 Nov; 10(11):1161-2. PMID: 15516907.
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    419. Parsons PE, Matthay MA, Ware LB, Eisner MD. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L426-31. PMID: 15516488.
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    420. Bandi VD, Munnur U, Matthay MA. Acute lung injury and acute respiratory distress syndrome in pregnancy. Crit Care Clin. 2004 Oct; 20(4):577-607. PMID: 15388190.
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    421. Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. PMID: 15524406.
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    422. Kallet RH, Alonso JA, Pittet JF, Matthay MA. Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. Respir Care. 2004 Sep; 49(9):1008-14. PMID: 15329171.
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    423. Brower RG, Lanken PN, MacIntyre N, Matthay MA, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22; 351(4):327-36. PMID: 15269312.
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    424. Sue RD, Matthay MA, Ware LB. Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Intensive Care Med. 2004 Oct; 30(10):1921-6. PMID: 15258730.
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    425. Matthay MA, Clements JA. Coagulation-dependent mechanisms and asthma. J Clin Invest. 2004 Jul; 114(1):20-3. PMID: 15232607.
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    426. Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
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    427. Hirsch J, Hansen KC, Burlingame AL, Matthay MA. Proteomics: current techniques and potential applications to lung disease. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L1-23. PMID: 15187006.
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    428. McAuley DF, Frank JA, Fang X, Matthay MA. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. PMID: 15241090.
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    429. Zemans RL, Matthay MA. Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury. Crit Care. 2004 Dec; 8(6):469-77. PMID: 15566618.
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    430. Ware LB, Eisner MD, Thompson BT, Parsons PE, Matthay MA. Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med. 2004 Oct 01; 170(7):766-72. PMID: 15201135.
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    431. Matthay MA, Ware LB. Plasma protein C levels in patients with acute lung injury: prognostic significance. Crit Care Med. 2004 May; 32(5 Suppl):S229-32. PMID: 15118523.
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    432. Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC. H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L448-53. PMID: 15121637.
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    433. Hastings RH, Folkesson HG, Matthay MA. Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L679-89. PMID: 15003932.
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    434. Zemans RL, Chatterjee K, Matthay MA. Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Am J Med. 2004 Mar 15; 116(6):424-6. PMID: 15006593.
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    435. Fang X, Song Y, Zemans R, Hirsch J, Matthay MA. Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L104-10. PMID: 14990396.
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    436. Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay MA. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol. 2004 Feb 15; 172(4):2668-77. PMID: 14764742.
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    437. McClintock DE, Matthay MA. Why does acute lung injury have no impact on mortality in patients with major trauma? Crit Care Med. 2004 Feb; 32(2):583-4. PMID: 14758183.
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    438. Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay MA, Duncan MW. Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1095-104. PMID: 14742308.
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    439. Krupa A, Kato H, Matthay MA, Kurdowska AK. Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1105-13. PMID: 14729508.
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    440. Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay MA. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp Lung Res. 2004 Jan-Feb; 30(1):31-42. PMID: 14967602.
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    441. Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN. The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities. Infect Immun. 2004 Jan; 72(1):546-58. PMID: 14688136.
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    442. Pastor CM, Matthay MA, Frossard JL. Pancreatitis-associated acute lung injury: new insights. Chest. 2003 Dec; 124(6):2341-51. PMID: 14665518.
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    443. Goodman RB, Pugin J, Lee JS, Matthay MA. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 2003 Dec; 14(6):523-35. PMID: 14563354.
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    444. Eisner MD, Parsons P, Matthay MA, Ware L, Greene K. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax. 2003 Nov; 58(11):983-8. PMID: 14586055.
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    445. Brower RG, Morris A, MacIntyre N, Matthay MA, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med. 2003 Nov; 31(11):2592-7. PMID: 14605529.
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    446. Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay MA. Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intensive Care Med. 2003 Nov; 29(11):2034-42. PMID: 14557856.
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    447. Cheng IW, Matthay MA. Acute lung injury and the acute respiratory distress syndrome. Crit Care Clin. 2003 Oct; 19(4):693-712. PMID: 14601715.
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    448. Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1088-94. PMID: 12959931.
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    449. Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med. 2003 Sep; 31(9):2309-15. PMID: 14501961.
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    450. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. PMID: 12930837.
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    451. Elia N, Tapponnier M, Matthay MA, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R. Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1043-50. PMID: 12842853.
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    452. Flori HR, Ware LB, Glidden D, Matthay MA. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2003 Jul; 4(3):315-21. PMID: 12831413.
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    457. Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res. 2003 Feb 15; 283(2):215-29. PMID: 12581741.
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    464. Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay MA, Clerici C. Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L1133-42. PMID: 12376368.
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    466. Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol. 2002 Nov; 161(5):1783-96. PMID: 12414525.
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    468. Ware LB, Matthay MA. Measuring microvascular blood flow in sepsis--a continuing challenge. Lancet. 2002 Oct 19; 360(9341):1187-8. PMID: 12401242.
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    475. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L163-9. PMID: 12060573.
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    476. Fang X, Yang B, Matthay MA, Verkman AS. Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. J Physiol. 2002 Jul 01; 542(Pt 1):63-9. PMID: 12096051.
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    478. Saint S, Savel RH, Matthay MA. Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections. Am J Respir Crit Care Med. 2002 Jun 01; 165(11):1475-9. PMID: 12045119.
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    479. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med. 2002 Jun; 28(6):705-11. PMID: 12107675.
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    480. Ware LB, Matthay MA. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L924-40. PMID: 11943656.
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    481. Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay MA. Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L1092-8. PMID: 11943675.
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    483. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med. 2002 Apr 25; 346(17):1281-6. PMID: 11973365.
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    484. Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay MA. Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002 Apr 01; 165(7):978-82. PMID: 11934725.
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    485. Matthay MA, Uchida T, Fang X. Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome. Curr Treat Options Cardiovasc Med. 2002 Apr; 4(2):139-149. PMID: 11858776.
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    486. Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay MA. Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest. 2002 Mar; 121(3 Suppl):69S-70S. PMID: 11893691.
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    487. Fang X, Fukuda N, Barbry P, Sartori C, Verkman AS, Matthay MA. Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol. 2002 Feb; 119(2):199-207. PMID: 11815669.
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    488. Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay MA. Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats. Anesthesiology. 2002 Feb; 96(2):392-9. PMID: 11818773.
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    489. Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, Welch WJ. Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. J Physiol. 2002 Jan 15; 538(Pt 2):583-97. PMID: 11790821.
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    490. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. PMID: 11790662.
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    491. Ware LB, Conner ER, Matthay MA. von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med. 2001 Dec; 29(12):2325-31. PMID: 11801836.
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    492. Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C. Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment. Am J Respir Cell Mol Biol. 2001 Nov; 25(5):554-61. PMID: 11713096.
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    494. Looney MR, Matthay MA. The Role of Protein C in Sepsis. Curr Infect Dis Rep. 2001 Oct; 3(5):413-418. PMID: 11559461.
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    495. Brower RG, Ware LB, Berthiaume Y, Matthay MA. Treatment of ARDS. Chest. 2001 Oct; 120(4):1347-67. PMID: 11591581.
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    497. Chesnutt MS, Nuckton TJ, Golden J, Folkesson HG, Matthay MA. Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis. Chest. 2001 Jul; 120(1):271-4. PMID: 11451848.
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    498. Song Y, Jayaraman S, Yang B, Matthay MA, Verkman AS. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Physiol. 2001 Jun; 117(6):573-82. PMID: 11382807.
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    501. Pittet JF, Lu LN, Morris DG, Modelska K, Welch WJ, Carey HV, Roux J, Matthay MA. Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats. J Immunol. 2001 May 15; 166(10):6301-10. PMID: 11342654.
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    504. Geiser TK, Kazmierczak BI, Garrity-Ryan LK, Matthay MA, Engel JN. Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair. Cell Microbiol. 2001 Apr; 3(4):223-36. PMID: 11298646.
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    506. Yost CS, Matthay MA, Gropper MA. Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Chest. 2001 Jan; 119(1):219-23. PMID: 11157607.
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    510. Song Y, Yang B, Matthay MA, Ma T, Verkman AS. Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1744-50. PMID: 11078688.
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    511. Frank JA, Wang Y, Osorio O, Matthay MA. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol (1985). 2000 Oct; 89(4):1255-65. PMID: 11007557.
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    514. Frank JA, Nuckton TJ, Matthay MA. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Crit Care Med. 2000 Jul; 28(7):2645-6. PMID: 10921610.
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    516. Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, Crystal RG. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Respir Cell Mol Biol. 2000 Jun; 22(6):657-64. PMID: 10837361.
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    521. Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med. 2000 Apr; 161(4 Pt 1):1185-90. PMID: 10764310.
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    524. Yang B, Fukuda N, van Hoek A, Matthay MA, Ma T, Verkman AS. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000 Jan 28; 275(4):2686-92. PMID: 10644730.
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    525. Jasmer RM, Matthay MA. Noninvasive ventilation for acute respiratory failure. J Clin Monit Comput. 2000; 16(5-6):403-8. PMID: 12580223.
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    526. Song Y, Ma T, Matthay MA, Verkman AS. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000 Jan; 115(1):17-27. PMID: 10613915.
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    527. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest. 2000 Jan; 105(1):93-100. PMID: 10619865.
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    528. Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF. Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Crit Care Med. 2000 Jan; 28(1):125-31. PMID: 10667511.
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    529. Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ, Repine JE. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med. 2000 Jan; 28(1):232-5. PMID: 10667529.
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    530. Kallet RH, Alonso JA, Luce JM, Matthay MA. Exacerbation of acute pulmonary edema during assisted mechanical ventilation using a low-tidal volume, lung-protective ventilator strategy. Chest. 1999 Dec; 116(6):1826-32. PMID: 10593817.
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    531. Eisner MD, Matthay MA. Health-related quality of life after acute lung injury. Crit Care Med. 1999 Dec; 27(12):2825-6. PMID: 10628634.
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    532. Modelska K, Pittet JF, Folkesson HG, Courtney Broaddus V, Matthay MA. Acid-induced lung injury. Protective effect of anti-interleukin-8 pretreatment on alveolar epithelial barrier function in rabbits. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1450-6. PMID: 10556104.
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    533. Laffon M, Pittet JF, Modelska K, Matthay MA, Young DM. Interleukin-8 mediates injury from smoke inhalation to both the lung endothelial and the alveolar epithelial barriers in rabbits. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 1):1443-9. PMID: 10556103.
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    534. Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA. Interobserver variability in applying a radiographic definition for ARDS. Chest. 1999 Nov; 116(5):1347-53. PMID: 10559098.
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    535. Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and beta-agonist therapy. J Appl Physiol (1985). 1999 Nov; 87(5):1852-60. PMID: 10562630.
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    536. Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF. alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock. Am J Physiol. 1999 10; 277(4):L760-8. PMID: 10516217.
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    538. Matthay MA, Geiser T, Matalon S, Ischiropoulos H. Oxidant-mediated lung injury in the acute respiratory distress syndrome. Crit Care Med. 1999 Sep; 27(9):2028-30. PMID: 10507639.
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    539. Khan SU, Salloum J, O'Donovan PB, Mascha EJ, Mehta AC, Matthay MA, Arroliga AC. Acute pulmonary edema after lung transplantation: the pulmonary reimplantation response. Chest. 1999 Jul; 116(1):187-94. PMID: 10424524.
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    540. Newman V, Gonzalez R, Matthay M, Dobbs L. HTI56, an integral apical membrane protein of the human alveolar type I cell, is a biochemical marker of acute lung injury. Chest. 1999 Jul; 116(1 Suppl):35S-36S. PMID: 10424584.
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    543. Matthay MA. Conference summary: acute lung injury. Chest. 1999 Jul; 116(1 Suppl):119S-126S. PMID: 10424631.
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    545. Ware LB, Golden JA, Finkbeiner WE, Matthay MA. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med. 1999 Mar; 159(3):980-8. PMID: 10051282.
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    546. Pugin J, Verghese G, Widmer MC, Matthay MA. The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med. 1999 Feb; 27(2):304-12. PMID: 10075054.
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    547. Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999 Feb; 103(4):555-61. PMID: 10021464.
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    548. Yang B, Folkesson HG, Yang J, Matthay MA, Ma T, Verkman AS. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol. 1999 01; 276(1):C76-81. PMID: 9886922.
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    549. Campbell AR, Folkesson HG, Berthiaume Y, Gutkowska J, Suzuki S, Matthay MA. Alveolar epithelial fluid clearance persists in the presence of moderate left atrial hypertension in sheep. J Appl Physiol (1985). 1999 Jan; 86(1):139-51. PMID: 9887124.
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    551. DiFederico EM, Burlingame JM, Kilpatrick SJ, Harrison M, Matthay MA. Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. Am J Obstet Gynecol. 1998 Oct; 179(4):925-33. PMID: 9790372.
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    552. Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA. Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin. Am J Physiol. 1998 09; 275(3):L478-90. PMID: 9728042.
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    553. Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA. Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med. 1998 Aug; 158(2):386-94. PMID: 9700111.
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    554. Parsons PE, Matthay M. Protective ventilation for the acute respiratory distress syndrome. N Engl J Med. 1998 Jul 16; 339(3):197; author reply 198-9. PMID: 9669913.
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    555. Bai C, Biwersi J, Verkman AS, Matthay MA. A mouse model to test the in vivo efficacy of chemical chaperones. J Pharmacol Toxicol Methods. 1998 Jul; 40(1):39-45. PMID: 9920533.
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    556. Ma T, Yang B, Matthay MA, Verkman AS. Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am J Respir Cell Mol Biol. 1998 Jul; 19(1):143-9. PMID: 9651190.
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    558. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med. 1998 Apr; 157(4 Pt 1):1332-47. PMID: 9563759.
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    559. Carter EP, Olveczky BP, Matthay MA, Verkman AS. High microvascular endothelial water permeability in mouse lung measured by a pleural surface fluorescence method. Biophys J. 1998 Apr; 74(4):2121-8. PMID: 9545071.
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    560. Artigas A, Bernard GR, Carlet J, Dreyfuss D, Gattinoni L, Hudson L, Lamy M, Marini JJ, Matthay MA, Pinsky MR, Spragg R, Suter PM. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies and issues related to recovery and remodeling. Intensive Care Med. 1998 Apr; 24(4):378-98. PMID: 9609420.
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    561. Dobbs LG, Gonzalez R, Matthay MA, Carter EP, Allen L, Verkman AS. Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2991-6. PMID: 9501203.
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    562. Matthay MA, Pittet JF, Jayr C. Just say NO to inhaled nitric oxide for the acute respiratory distress syndrome. Crit Care Med. 1998 Jan; 26(1):1-2. PMID: 9428528.
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    563. Carter EP, Umenishi F, Matthay MA, Verkman AS. Developmental changes in water permeability across the alveolar barrier in perinatal rabbit lung. J Clin Invest. 1997 Sep 01; 100(5):1071-8. PMID: 9276723.
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    564. Chesnutt AN, Matthay MA, Tibayan FA, Clark JG. Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med. 1997 Sep; 156(3 Pt 1):840-5. PMID: 9310002.
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    565. Modelska K, Matthay MA, McElroy MC, Pittet JF. Upregulation of alveolar liquid clearance after fluid resuscitation for hemorrhagic shock in rats. Am J Physiol. 1997 Aug; 273(2 Pt 1):L305-14. PMID: 9277441.
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    566. Tibayan FA, Chesnutt AN, Folkesson HG, Eandi J, Matthay MA. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug; 156(2 Pt 1):438-44. PMID: 9279221.
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    567. Folkesson HG, Matthay MA. Inhibition of CD18 or CD11b attenuates acute lung injury after acid instillation in rabbits. J Appl Physiol (1985). 1997 Jun; 82(6):1743-50. PMID: 9173936.
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    568. Jasmer RM, Luce JM, Matthay MA. Noninvasive positive pressure ventilation for acute respiratory failure: underutilized or overrated? Chest. 1997 Jun; 111(6):1672-8. PMID: 9187192.
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    569. Smith WS, Matthay MA. Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest. 1997 May; 111(5):1326-33. PMID: 9149590.
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    570. Garat C, Meignan M, Matthay MA, Luo DF, Jayr C. Alveolar epithelial fluid clearance mechanisms are intact after moderate hyperoxic lung injury in rats. Chest. 1997 May; 111(5):1381-8. PMID: 9149598.
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    571. Oliver BL, Garat C, Pytela R, Matthay MA. Protein tyrosine phosphatases mediate cell readhesion in alveolar epithelial cells mechanically separated from in vitro matrix. Am J Respir Cell Mol Biol. 1997 May; 16(5):613-20. PMID: 9160844.
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    572. Pittet JF, Mackersie RC, Martin TR, Matthay MA. Biological markers of acute lung injury: prognostic and pathogenetic significance. Am J Respir Crit Care Med. 1997 Apr; 155(4):1187-205. PMID: 9105054.
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    573. Chesnutt AN, Kheradmand F, Folkesson HG, Alberts M, Matthay MA. Soluble transforming growth factor-alpha is present in the pulmonary edema fluid of patients with acute lung injury. Chest. 1997 Mar; 111(3):652-6. PMID: 9118703.
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    574. Sakuma T, Folkesson HG, Suzuki S, Okaniwa G, Fujimura S, Matthay MA. Beta-adrenergic agonist stimulated alveolar fluid clearance in ex vivo human and rat lungs. Am J Respir Crit Care Med. 1997 Feb; 155(2):506-12. PMID: 9032186.
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    575. Rezaiguia S, Garat C, Delclaux C, Meignan M, Fleury J, Legrand P, Matthay MA, Jayr C. Acute bacterial pneumonia in rats increases alveolar epithelial fluid clearance by a tumor necrosis factor-alpha-dependent mechanism. J Clin Invest. 1997 Jan 15; 99(2):325-35. PMID: 9006001.
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    576. Garat C, Kheradmand F, Albertine KH, Folkesson HG, Matthay MA. Soluble and insoluble fibronectin increases alveolar epithelial wound healing in vitro. Am J Physiol. 1996 Nov; 271(5 Pt 1):L844-53. PMID: 8944729.
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    577. Umenishi F, Carter EP, Yang B, Oliver B, Matthay MA, Verkman AS. Sharp increase in rat lung water channel expression in the perinatal period. Am J Respir Cell Mol Biol. 1996 Nov; 15(5):673-9. PMID: 8918374.
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    578. Kurdowska A, Miller EJ, Noble JM, Baughman RP, Matthay MA, Brelsford WG, Cohen AB. Anti-IL-8 autoantibodies in alveolar fluid from patients with the adult respiratory distress syndrome. J Immunol. 1996 Sep 15; 157(6):2699-706. PMID: 8805676.
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    579. Miller EJ, Cohen AB, Matthay MA. Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis. Crit Care Med. 1996 Sep; 24(9):1448-54. PMID: 8797614.
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    580. Carter EP, Matthay MA, Farinas J, Verkman AS. Transalveolar osmotic and diffusional water permeability in intact mouse lung measured by a novel surface fluorescence method. J Gen Physiol. 1996 Sep; 108(3):133-42. PMID: 8882859.
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    581. Matthay MA, Rosen GD. Acid aspiration induced lung injury. New insights and therapeutic options. Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 1):277-8. PMID: 8756794.
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    582. Folkesson HG, Pittet JF, Nitenberg G, Matthay MA. Transforming growth factor-alpha increases alveolar liquid clearance in anesthetized ventilated rats. Am J Physiol. 1996 Aug; 271(2 Pt 1):L236-44. PMID: 8770062.
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    583. Pittet JF, Brenner TJ, Modelska K, Matthay MA. Alveolar liquid clearance is increased by endogenous catecholamines in hemorrhagic shock in rats. J Appl Physiol (1985). 1996 Aug; 81(2):830-7. PMID: 8872653.
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    584. Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 1996 May 30; 334(22):1469-70. PMID: 8618587.
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    585. Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlsson BW, Hastings RH. Alveolar epithelial clearance of protein. J Appl Physiol (1985). 1996 May; 80(5):1431-45. PMID: 8727524.
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    586. DiFederico EM, Harrison M, Matthay MA. Pulmonary edema in a woman following fetal surgery. Chest. 1996 Apr; 109(4):1114-7. PMID: 8635343.
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    587. Matthay MA, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol. 1996 Apr; 270(4 Pt 1):L487-503. PMID: 8928808.
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    588. Folkesson HG, Matthay MA, Frigeri A, Verkman AS. Transepithelial water permeability in microperfused distal airways. Evidence for channel-mediated water transport. J Clin Invest. 1996 Feb 01; 97(3):664-71. PMID: 8609221.
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    589. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 Jan 01; 183(1):109-17. PMID: 8551213.
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    590. Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JP, Matthay MA. Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med. 1995 Dec; 152(6 Pt 1):1818-24. PMID: 8520742.
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    591. Garat C, Rezaiguia S, Meignan M, D'Ortho MP, Harf A, Matthay MA, Jayr C. Alveolar endotoxin increases alveolar liquid clearance in rats. J Appl Physiol (1985). 1995 Dec; 79(6):2021-8. PMID: 8847269.
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    592. Hastings RH, Folkesson HG, Petersen V, Ciriales R, Matthay MA. Cellular uptake of albumin from lungs of anesthetized rabbits. Am J Physiol. 1995 Oct; 269(4 Pt 1):L453-62. PMID: 7485517.
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    593. Folkesson HG, Matthay MA, Hébert CA, Broaddus VC. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest. 1995 Jul; 96(1):107-16. PMID: 7615779.
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    594. Rubenfeld GD, Doyle RL, Matthay MA. Evaluation of definitions of ARDS. Am J Respir Crit Care Med. 1995 Apr; 151(4):1270-1. PMID: 7697267.
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    595. Pittet JF, Wiener-Kronish JP, Serikov V, Matthay MA. Resistance of the alveolar epithelium to injury from septic shock in sheep. Am J Respir Crit Care Med. 1995 Apr; 151(4):1093-100. PMID: 7697237.
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    596. Schwartz DE, Matthay MA, Cohen NH. Death and other complications of emergency airway management in critically ill adults. A prospective investigation of 297 tracheal intubations. Anesthesiology. 1995 Feb; 82(2):367-76. PMID: 7856895.
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    597. Schnapp LM, Chin DP, Szaflarski N, Matthay MA. Frequency and importance of barotrauma in 100 patients with acute lung injury. Crit Care Med. 1995 Feb; 23(2):272-8. PMID: 7867352.
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    598. Matthay MA. Fibrosing alveolitis in the adult respiratory distress syndrome. Ann Intern Med. 1995 Jan 01; 122(1):65-6. PMID: 7985899.
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    599. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA. Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Am J Physiol. 1994 Dec; 267(6 Pt 1):L728-38. PMID: 7810677.
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    600. Folkesson HG, Kheradmand F, Matthay MA. The effect of salt water on alveolar epithelial barrier function. Am J Respir Crit Care Med. 1994 Dec; 150(6 Pt 1):1555-63. PMID: 7952614.
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    601. Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay MA. Stimulation of lung epithelial liquid clearance by endogenous release of catecholamines in septic shock in anesthetized rats. J Clin Invest. 1994 Aug; 94(2):663-71. PMID: 8040320.
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    602. Sakuma T, Okaniwa G, Nakada T, Nishimura T, Fujimura S, Matthay MA. Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med. 1994 Aug; 150(2):305-10. PMID: 8049807.
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    603. Folkesson HG, Matthay MA, Hasegawa H, Kheradmand F, Verkman AS. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4970-4. PMID: 7515184.
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    604. Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA. Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G, and SP-A in rabbits. Am J Physiol. 1994 May; 266(5 Pt 1):L544-52. PMID: 8203547.
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    605. Matthay MA. Function of the alveolar epithelial barrier under pathologic conditions. Chest. 1994 Mar; 105(3 Suppl):67S-74S. PMID: 8131616.
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    606. Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem. 1994 Feb 25; 269(8):5497-500. PMID: 7509789.
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    607. Kelly BJ, Matthay MA. Prevalence and severity of neurologic dysfunction in critically ill patients. Influence on need for continued mechanical ventilation. Chest. 1993 Dec; 104(6):1818-24. PMID: 8252971.
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    608. Matthay MA, Folkesson HG, Campagna A, Kheradmand F. Alveolar epithelial barrier and acute lung injury. New Horiz. 1993 Nov; 1(4):613-22. PMID: 8087581.
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    609. Wiener-Kronish JP, Sakuma T, Kudoh I, Pittet JF, Frank D, Dobbs L, Vasil ML, Matthay MA. Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits. J Appl Physiol (1985). 1993 Oct; 75(4):1661-9. PMID: 8282618.
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    610. Pittet JF, Matthay MA, Pier G, Grady M, Wiener-Kronish JP. Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody. J Clin Invest. 1993 Sep; 92(3):1221-8. PMID: 8376581.
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    611. Serikov VB, Grady M, Matthay MA. Effect of temperature on alveolar liquid and protein clearance in an in situ perfused goat lung. J Appl Physiol (1985). 1993 Aug; 75(2):940-7. PMID: 8226499.
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    612. Cohen AB, Stevens MD, Miller EJ, Atkinson MA, Mullenbach G, Maunder RJ, Martin TR, Wiener-Kronish JP, Matthay MA. Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS. Am J Physiol. 1993 May; 264(5 Pt 1):L490-5. PMID: 8498526.
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    613. Jayr C, Matthay MA, Goldstone J, Gold WM, Wiener-Kronish JP. Preoperative and intraoperative factors associated with prolonged mechanical ventilation. A study in patients following major abdominal vascular surgery. Chest. 1993 Apr; 103(4):1231-6. PMID: 8131471.
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    614. Newman W, Beall LD, Carson CW, Hunder GG, Graben N, Randhawa ZI, Gopal TV, Wiener-Kronish J, Matthay MA. Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol. 1993 Jan 15; 150(2):644-54. PMID: 7678280.
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    615. Sakuma T, Pittet JF, Jayr C, Matthay MA. Alveolar liquid and protein clearance in the absence of blood flow or ventilation in sheep. J Appl Physiol (1985). 1993 Jan; 74(1):176-85. PMID: 7680335.
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    616. Hastings RH, Grady M, Sakuma T, Matthay MA. Clearance of different-sized proteins from the alveolar space in humans and rabbits. J Appl Physiol (1985). 1992 Oct; 73(4):1310-6. PMID: 1447074.
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    617. Espiritu RF, Pittet JF, Matthay MA, Goetzl EJ. Neuropeptides in pulmonary edema fluid of adult respiratory distress syndrome. Inflammation. 1992 Oct; 16(5):509-17. PMID: 1428125.
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    618. Cohen DS, Matthay MA, Cogan MG, Murray JF. Pulmonary edema associated with salt water near-drowning: new insights. Am Rev Respir Dis. 1992 Sep; 146(3):794-6. PMID: 1519866.
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    619. Segredo V, Caldwell JE, Matthay MA, Sharma ML, Gruenke LD, Miller RD. Persistent paralysis in critically ill patients after long-term administration of vecuronium. N Engl J Med. 1992 Aug 20; 327(8):524-8. PMID: 1353252.
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    620. Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner-Kronish JP, Sticherling M, Christophers E, Matthay MA. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis. 1992 Aug; 146(2):427-32. PMID: 1489135.
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    621. Kilpatrick SJ, Matthay MA. Obstetric patients requiring critical care. A five-year review. Chest. 1992 May; 101(5):1407-12. PMID: 1582306.
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    622. Callaham M, Barton C, Matthay M. Effect of epinephrine on the ability of end-tidal carbon dioxide readings to predict initial resuscitation from cardiac arrest. Crit Care Med. 1992 Mar; 20(3):337-43. PMID: 1541094.
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    623. Jayr C, Matthay MA. Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep. J Appl Physiol (1985). 1991 Nov; 71(5):1679-87. PMID: 1761463.
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    624. Wiener-Kronish JP, Albertine KH, Matthay MA. Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest. 1991 Sep; 88(3):864-75. PMID: 1885774.
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    625. Matthay MA, Matthay RA. Critical care medicine. JAMA. 1991 Jun 19; 265(23):3109-11. PMID: 2041115.
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    626. Smedira N, Gates L, Hastings R, Jayr C, Sakuma T, Pittet JF, Matthay MA. Alveolar and lung liquid clearance in anesthetized rabbits. J Appl Physiol (1985). 1991 Apr; 70(4):1827-35. PMID: 2055861.
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    627. Matthay MA. Resolution of pulmonary edema. New insights. West J Med. 1991 Mar; 154(3):315-21. PMID: 2028590.
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    628. Matthay MA, Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1250-7. PMID: 2252240.
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    629. Matthay MA. The adult respiratory distress syndrome. Definition and prognosis. Clin Chest Med. 1990 Dec; 11(4):575-80. PMID: 2268989.
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    630. Wiedemann HP, Matthay MA, Gillis CN. Pulmonary endothelial cell injury and altered lung metabolic function. Early detection of the adult respiratory distress syndrome and possible functional significance. Clin Chest Med. 1990 Dec; 11(4):723-36. PMID: 2268998.
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    631. Rubin DB, Wiener-Kronish JP, Murray JF, Green DR, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA. Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J Clin Invest. 1990 Aug; 86(2):474-80. PMID: 2384595.
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    632. Wiener-Kronish JP, Gropper MA, Matthay MA. The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Br J Anaesth. 1990 Jul; 65(1):107-29. PMID: 2200479.
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    633. Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA. Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Anesthesiology. 1990 Apr; 72(4):607-12. PMID: 2321775.
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    634. Heffner JE, Matthay MA. The case for oxidants in the adult respiratory distress syndrome--"elementary, Dr. Watson". J Lab Clin Med. 1990 Apr; 115(4):394-5. PMID: 2324608.
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    635. Segredo V, Matthay MA, Sharma ML, Gruenke LD, Caldwell JE, Miller RD. Prolonged neuromuscular blockade after long-term administration of vecuronium in two critically ill patients. Anesthesiology. 1990 Mar; 72(3):566-70. PMID: 1968730.
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    636. Berthiaume Y, Albertine KH, Grady M, Fick G, Matthay MA. Protein clearance from the air spaces and lungs of unanesthetized sheep over 144 h. J Appl Physiol (1985). 1989 Nov; 67(5):1887-97. PMID: 2600023.
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    637. Martin TR, Pistorese BP, Chi EY, Goodman RB, Matthay MA. Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest. 1989 Nov; 84(5):1609-19. PMID: 2553777.
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    638. Matthay MA. New modes of mechanical ventilation for ARDS. How should they be evaluated? Chest. 1989 Jun; 95(6):1175-7. PMID: 2721246.
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    639. Matthay MA, Wiener-Kronish JP. Respiratory management after cardiac surgery. Chest. 1989 Feb; 95(2):424-34. PMID: 2914495.
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    640. Matthay MA. The adult respiratory distress syndrome. New insights into diagnosis, pathophysiology, and treatment. West J Med. 1989 Feb; 150(2):187-94. PMID: 2658327.
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    641. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC. Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. J Clin Invest. 1988 Oct; 82(4):1422-9. PMID: 3170750.
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    642. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988 Sep; 138(3):720-3. PMID: 3202424.
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    643. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA. Alveolar liquid and protein clearance from normal dog lungs. J Appl Physiol (1985). 1988 Aug; 65(2):585-93. PMID: 3170409.
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    644. Ratnoff WD, Matthay MA, Wong MY, Ito Y, Vu KH, Wiener-Kronish J, Goetzl EJ. Sulfidopeptide-leukotriene peptidases in pulmonary edema fluid from patients with the adult respiratory distress syndrome. J Clin Immunol. 1988 Jul; 8(4):250-8. PMID: 2842367.
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    645. Aberle DR, Wiener-Kronish JP, Webb WR, Matthay MA. Hydrostatic versus increased permeability pulmonary edema: diagnosis based on radiographic criteria in critically ill patients. Radiology. 1988 Jul; 168(1):73-9. PMID: 3380985.
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    646. Wiener-Kronish JP, Matthay MA. Pleural effusions associated with hydrostatic and increased permeability pulmonary edema. Chest. 1988 Apr; 93(4):852-8. PMID: 3349844.
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    647. Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay MA. Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension. Chest. 1987 Dec; 92(6):967-70. PMID: 3677841.
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    648. Dean NC, Amend WC, Matthay MA. Adult respiratory distress syndrome related to antilymphocyte globulin therapy. Chest. 1987 Apr; 91(4):619-20. PMID: 3549177.
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    649. Berthiaume Y, Staub NC, Matthay MA. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J Clin Invest. 1987 Feb; 79(2):335-43. PMID: 2879851.
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    650. Biondi JW, Hines RL, Barash PG, Baker CC, Matthay MA, Matthay RA. The adult respiratory distress syndrome. Yale J Biol Med. 1986 Nov-Dec; 59(6):575-97. PMID: 3538681.
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    651. Curtis JL, Mahlmeister M, Fink JB, Lampe G, Matthay MA, Stulbarg MS. Helium-oxygen gas therapy. Use and availability for the emergency treatment of inoperable airway obstruction. Chest. 1986 Sep; 90(3):455-7. PMID: 3743166.
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    652. Fein A, Wiener-Kronish JP, Niederman M, Matthay MA. Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies? Crit Care Clin. 1986 Jul; 2(3):429-53. PMID: 3331557.
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    653. Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K. Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Anesthesiology. 1986 Jun; 64(6):764-70. PMID: 3487261.
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    654. Bigby TD, Serota ML, Tierney LM, Matthay MA. Clinical spectrum of pulmonary mucormycosis. Chest. 1986 Mar; 89(3):435-9. PMID: 3081299.
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    655. Eisendrath SJ, Link N, Matthay M. Intensive care unit: how stressful for physicians? Crit Care Med. 1986 Feb; 14(2):95-8. PMID: 3943330.
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    656. Wiener-Kronish JP, Matthay MA, Callen PW, Filly RA, Gamsu G, Staub NC. Relationship of pleural effusions to pulmonary hemodynamics in patients with congestive heart failure. Am Rev Respir Dis. 1985 Dec; 132(6):1253-6. PMID: 3907444.
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    657. Matthay MA. Cellular basis for injury and repair in the adult respiratory distress syndrome. West J Med. 1985 Nov; 143(5):665-7. PMID: 3909644.
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    658. Matthay MA. Pathophysiology of pulmonary edema. Clin Chest Med. 1985 Sep; 6(3):301-14. PMID: 3907942.
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    659. Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA. Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. Am Heart J. 1985 Aug; 110(2):335-41. PMID: 3875274.
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    660. Matthay MA, Eschenbacher WL, Goetzl EJ. Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. J Clin Immunol. 1984 Nov; 4(6):479-83. PMID: 6511865.
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    661. Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, Murray JF. Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Respir Dis. 1984 Nov; 130(5):791-6. PMID: 6497161.
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    662. Bongard FS, Matthay M, Mackersie RC, Lewis FR. Morphologic and physiologic correlates of increased extravascular lung water. Surgery. 1984 Aug; 96(2):395-403. PMID: 6463867.
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    663. Wiedemann HP, Matthay MA, Matthay RA. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 2). Chest. 1984 May; 85(5):656-68. PMID: 6713975.
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    664. Wiedemann HP, Matthay MA, Matthay RA. Cardiovascular-pulmonary monitoring in the intensive care unit (Part 1). Chest. 1984 Apr; 85(4):537-49. PMID: 6368142.
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    665. Matthay MA. Invasive hemodynamic monitoring in critically ill patients. Clin Chest Med. 1983 May; 4(2):233-49. PMID: 6342922.
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    666. Prewitt RM, Matthay MA, Ghignone M. Hemodynamic management in the adult respiratory distress syndrome. Clin Chest Med. 1983 May; 4(2):251-68. PMID: 6342923.
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    667. Landolt CC, Matthay MA, Albertine KH, Roos PJ, Wiener-Kronish JP, Staub NC. Overperfusion, hypoxia, and increased pressure cause only hydrostatic pulmonary edema in anesthetized sheep. Circ Res. 1983 Mar; 52(3):335-41. PMID: 6825224.
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