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Michael Matthay, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-353-1206
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B.1969English
    University of PennsylvaniaM.D.1973School of Medicine
    University of Colorado Medical CenterInternship and Residency1976Internal Medicine
    University of California, San FranciscoFellowship1978Pulmonary DIvision
    University of California, San FranciscoFellowship1979Cardiovascular Research Institute

    Collapse Overview 
    Collapse Overview
    Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    1/1: ARREST RESPIRATORY FAILURE DUE TO PNEUMONIA (ARREST PNEUMONIA)
    NIH UH3HL141722Sep 23, 2019 - Aug 31, 2024
    Role: Co-Principal Investigator
    1/1: ARREST RESPIRATORY FAILURE DUE TO PNEUMONIA (ARREST PNEUMONIA)
    NIH UG3HL141722Sep 23, 2019 - Aug 31, 2020
    Role: Co-Principal Investigator
    Prevention and Early Treatment of Acute Lung Injury
    NIH U01HL123004Jun 17, 2014 - Apr 30, 2021
    Role: Principal Investigator
    Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury
    NIH U01HL108713Sep 1, 2011 - Jun 30, 2018
    Role: Principal Investigator
    Title: Long-Term Oxygen Treatment Trial (LOTT) - Data Coordinating Center
    NIH N01HR000000Jan 3, 2011 - Dec 31, 2015
    Role: Co-Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH N01HR56166-16-0-1Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH N01HR56166-16-0-4Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - ALTA Protocol
    NIH/NHLBI N01HR56166Sep 30, 2005 - Sep 29, 2012
    Role: Co-Principal Investigator
    ARDS - EDEN Protocol
    NIH N01HR56166-6-0-3Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH N01HR56166-7-0-1Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH N01HR56166-9-0-1Sep 30, 2005 - Nov 30, 2011
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    SCCOR in translational research in Acute Lung Injury
    NIH P50HL074005Sep 30, 2003 - Jun 30, 2010
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Resolution of Clinical Lung Injury
    NIH R37HL051856Apr 1, 1996 - Mar 31, 2018
    Role: Principal Investigator
    RESOLUTION OF CLINICAL LUNG INJURY
    NIH R01HL051856Apr 1, 1996 - Mar 31, 2006
    Role: Principal Investigator
    CCTG CLINICAL NETWORK FOR ARDS TREATMENT--CRITICAL CARE
    NIH/NHLBI N01HR046059Sep 30, 1994 - Sep 29, 2001
    Role: Principal Investigator
    Lung Fluid Balance and Mesenchymal Stem Cells
    NIH R01HL051854Apr 8, 1994 - Jun 30, 2014
    Role: Principal Investigator
    ALVEOLAR EPITHELIAL LIQUID AND PROTEIN CLEARANCE
    NIH R01HL040626Jun 1, 1988 - Nov 30, 1989
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PATHOPHYSIOLOGY OF LUNG LIQUID &PROTEIN EXCHANGE
    NIH P01HL025816Jun 1, 1980 - May 31, 1994
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included? Lancet Respir Med. 2021 Apr 26. PMID: 33915103.
      View in: PubMed   Mentions:    Fields:    
    2. Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome. Thorax. 2021 Apr 22. PMID: 33888572.
      View in: PubMed   Mentions:    Fields:    
    3. Inhibition of the Lipoxin A4 and Resolvin D1 Receptor Impairs Host Response to Acute Lung Injury Caused by Pneumococcal Pneumonia in Mice. Am J Physiol Lung Cell Mol Physiol. 2021 Apr 06. PMID: 33822656.
      View in: PubMed   Mentions:    Fields:    
    4. Healthy versus inflamed lung environments differentially effect MSCs. Eur Respir J. 2021 Apr 01. PMID: 33795318.
      View in: PubMed   Mentions:    Fields:    
    5. Impaired antibacterial immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. medRxiv. 2021 Mar 26. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium+ , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 33791731.
      View in: PubMed   Mentions:
    6. Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade. Signal Transduct Target Ther. 2021 Feb 27; 6(1):97. Ali G, Zhang M, Zhao R, Jain KG, Chang J, Komatsu S, Zhou B, Liang J, Matthay MA, Ji HL. PMID: 33640905.
      View in: PubMed   Mentions:
    7. The ARREST Pneumonia (Arrest Respiratory Failure due to Pneumonia) Trial: Rationale and Design. Ann Am Thorac Soc. 2021 Jan 25. Levitt JE, Festic E, Desai M, Hedlin H, Mahaffey KW, Rogers AJ, Gajic O, Matthay MA. PMID: 33493423.
      View in: PubMed   Mentions:    Fields:    
    8. Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 03; 591(7848):124-130. PMID: 33494096.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14. Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C. PMID: 33469573.
      View in: PubMed   Mentions:
    10. Molecular Markers of Telomere Dysfunction and Senescence are Common Findings in the Usual Interstitial Pneumonia Pattern of Lung Fibrosis. Histopathology. 2021 Jan 11. Lee JS, La J, Aziz S, Dobrinskikh E, Brownell R, Jones KD, Achtar-Zadeh N, Green G, Elicker BM, Golden JA, Matthay MA, Kukreja J, Schwartz DA, Wolters PJ. PMID: 33432658.
      View in: PubMed   Mentions:    Fields:    
    11. The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness. J Clin Invest. 2021 Jan 04; 131(1). Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff E, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell J, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD. PMID: 32931480.
      View in: PubMed   Mentions:    Fields:    
    12. The Pulmonary Metatranscriptome Prior to Pediatric Hematopoietic Cell Transplantation Identifies Post-HCT Lung Injury. Blood. 2020 Dec 23. Zinter MS, Lindemans C, Versluys B, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJJ, DeRisi JL. PMID: 33512420.
      View in: PubMed   Mentions:    Fields:    
    13. A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis. Am J Physiol Lung Cell Mol Physiol. 2020 Dec 23. Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell CA, Matthay MA. PMID: 33355521.
      View in: PubMed   Mentions:    Fields:    
    14. A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. N Engl J Med. 2020 Dec 22. Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Davey VJ, Goodman A, Higgs ES, Murray DD, Murray TA, Paredes R, Parmar MKB, Phillips AN, Reilly C, Sharma S, Dewar RL, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD. PMID: 33356051.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Corticosteroids, COVID-19 pneumonia, and acute respiratory distress syndrome. J Clin Invest. 2020 12 01; 130(12):6218-6221. Matthay MA, Wick KD. PMID: 32976118.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    16. Biological Mechanisms of COVID-19 Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2020 12 01; 202(11):1489-1491. Matthay MA, Leligdowicz A, Liu KD. PMID: 32997945.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    17. Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate. Am J Respir Cell Mol Biol. 2020 12; 63(6):748-757. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE. PMID: 32822237.
      View in: PubMed   Mentions:    Fields:    
    18. Alternative Tobacco Product Use in Critically Ill Patients. Int J Environ Res Public Health. 2020 Nov 24; 17(23). Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS. PMID: 33255164.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Phenotypes and personalized medicine in the acute respiratory distress syndrome. Intensive Care Med. 2020 Dec; 46(12):2136-2152. Matthay MA, Arabi YM, Siegel ER, Ware LB, Bos LDJ, Sinha P, Beitler JR, Wick KD, Curley MAQ, Constantin JM, Levitt JE, Calfee CS. PMID: 33206201.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2020 11 09. Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM. PMID: 33165621.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    21. Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies. Intensive Care Med. 2020 Dec; 46(12):2153-2156. Ware LB, Matthay MA, Mebazaa A. PMID: 33136196.
      View in: PubMed   Mentions: 1     Fields:    
    22. Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv. 2020 Oct 29. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140050.
      View in: PubMed   Mentions:
    23. Dexamethasone in hospitalised patients with COVID-19: addressing uncertainties. Lancet Respir Med. 2020 12; 8(12):1170-1172. Matthay MA, Thompson BT. PMID: 33129421.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    24. Global Absence and Targeting of Protective Immune States in Severe COVID-19. Res Sq. 2020 Oct 28. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140041.
      View in: PubMed   Mentions:
    25. Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury. Am J Physiol Renal Physiol. 2020 12 01; 319(6):F979-F987. Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD. PMID: 33044866.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020 Nov; 22(11):1295-1306. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. PMID: 33046884.
      View in: PubMed   Mentions:    Fields:    
    27. Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation. PLoS One. 2020; 15(10):e0240319. Wilfong EM, Croze R, Fang X, Schwede M, Niemi E, López GY, Lee JW, Nakamura MC, Matthay MA. PMID: 33021986.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung. Intensive Care Med Exp. 2020 Sep 21; 8(1):56. Leligdowicz A, Ross JT, Nesseler N, Matthay MA. PMID: 32955627.
      View in: PubMed   Mentions:
    29. Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Am J Respir Crit Care Med. 2020 09 15; 202(6):885-887. Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N. PMID: 32357306.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    30. Insufficient hyperfibrinolysis in COVID-19: a systematic review of thrombolysis based on meta-analysis and meta-regression. medRxiv. 2020 Sep 11. Ji HJ, Su Z, Zhao R, Komissarov AA, Yi G, Liu SL, Idell S, Matthay MA. PMID: 32935113.
      View in: PubMed   Mentions:
    31. NT-proBNP levels in the identification and classification of pulmonary transfusion reactions. Transfusion. 2020 Nov; 60(11):2548-2556. Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL. PMID: 32905629.
      View in: PubMed   Mentions:    Fields:    
    32. Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. Am J Physiol Lung Cell Mol Physiol. 2020 12 01; 319(6):L908-L925. Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S. PMID: 32901521.
      View in: PubMed   Mentions:    Fields:    
    33. Is a "Cytokine Storm" Relevant to COVID-19? JAMA Intern Med. 2020 09 01; 180(9):1152-1154. Sinha P, Matthay MA, Calfee CS. PMID: 32602883.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCellsPHPublic Health
    34. Need for Additional Trials of Vitamin C for Sepsis. JAMA. 2020 08 11; 324(6):607-608. Files DC, Liu KD, Matthay M. PMID: 32780134.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure. Pediatr Pulmonol. 2020 10; 55(10):2730-2736. Ward SL, Dahmer MK, Weeks HM, Sapru A, Quasney MW, Curley MAQ, Liu KD, Matthay MA, Flori HR. PMID: 32725941.
      View in: PubMed   Mentions:    Fields:    
    36. Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep. Am J Respir Crit Care Med. 2020 08 01; 202(3):383-392. Millar JE, Bartnikowski N, Passmore MR, Obonyo NG, Malfertheiner MV, von Bahr V, Redd MA, See Hoe L, Ki KK, Pedersen S, Boyle AJ, Baillie JK, Shekar K, Palpant N, Suen JY, Matthay MA, McAuley DF, Fraser JF. PMID: 32293914.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    37. Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy. Crit Care. 2020 07 11; 24(1):416. Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD. PMID: 32653023.
      View in: PubMed   Mentions:    Fields:    
    38. Extracellular Vesicles: A New Frontier for Research in Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2020 07; 63(1):15-24. Mahida RY, Matsumoto S, Matthay MA. PMID: 32109144.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    39. The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L218-L227. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA. PMID: 32519893.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    40. Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Crit Care Med. 2020 Jun; 48(6):830-837. Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS. PMID: 32317598.
      View in: PubMed   Mentions:    Fields:    
    41. Impact of Bilateral Infiltrates on Inflammatory Biomarker Levels and Clinical Outcomes of Children With Oxygenation Defect. Crit Care Med. 2020 Jun; 48(6):e498-e504. Kohne JG, Dahmer MK, Weeks HM, Kaciroti N, Quasney MW, Sapru A, Curley MAQ, Matthay M, Flori H. PMID: 32317601.
      View in: PubMed   Mentions:    Fields:    
    42. Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels. Br J Pharmacol. 2020 Jul; 177(13):3091-3106. Zhao R, Ali G, Nie HG, Chang Y, Bhattarai D, Su X, Zhao X, Matthay MA, Ji HL. PMID: 32133621.
      View in: PubMed   Mentions: 5     Fields:    
    43. Patterns and Trends in Advance Care Planning Among Older Adults Who Received Intensive Care at the End of Life. JAMA Intern Med. 2020 05 01; 180(5):786-789. Block BL, Jeon SY, Sudore RL, Matthay MA, Boscardin WJ, Smith AK. PMID: 32119031.
      View in: PubMed   Mentions: 1     Fields:    
    44. The potential of lipid mediator networks as ocular surface therapeutics and biomarkers. Ocul Surf. 2020 Apr 29. Flitter BA, Fang X, Matthay MA, Gronert K. PMID: 32360792.
      View in: PubMed   Mentions:    Fields:    
    45. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun. 2020 04 21; 11(1):1920. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. PMID: 32317643.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    46. Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. Chest. 2020 Sep; 158(3):1027-1035. Dahmer MK, Flori H, Sapru A, Kohne J, Weeks HM, Curley MAQ, Matthay MA, Quasney MW. PMID: 32275979.
      View in: PubMed   Mentions: 1     Fields:    
    47. Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Respir Res. 2020 Apr 07; 21(1):81. Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M. PMID: 32264897.
      View in: PubMed   Mentions: 1     Fields:    
    48. Gender Differences in Authorship of Critical Care Literature. Am J Respir Crit Care Med. 2020 04 01; 201(7):840-847. Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ. PMID: 31968182.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    49. Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility. Physiol Rev. 2020 07 01; 100(3):1065-1075. Ji HL, Zhao R, Matalon S, Matthay MA. PMID: 32216698.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCellsPHPublic Health
    50. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med. 2020 06; 46(6):1222-1231. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS. PMID: 32206845.
      View in: PubMed   Mentions: 4     Fields:    
    51. Treatment for severe acute respiratory distress syndrome from COVID-19. Lancet Respir Med. 2020 05; 8(5):433-434. Matthay MA, Aldrich JM, Gotts JE. PMID: 32203709.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCellsPHPublic Health
    52. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med. 2020 Mar 09. Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. PMID: 32150460.
      View in: PubMed   Mentions:    Fields:    
    53. Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study. J Thorac Cardiovasc Surg. 2020 Nov; 160(5):1385-1395.e6. Hamilton BCS, Dincheva GR, Matthay MA, Hays S, Singer JP, Brzezinski M, Kukreja J. PMID: 32252988.
      View in: PubMed   Mentions:    Fields:    
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    57. Peripheral blood leukocyte telomere length is associated with survival of sepsis patients. Eur Respir J. 2020 01; 55(1). Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. PMID: 31619475.
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    62. The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury. PLoS One. 2019; 14(11):e0225601. Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD. PMID: 31770424.
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    63. Therapeutic Effects of Hyaluronic Acid in Bacterial Pneumonia in Ex Vivo Perfused Human Lungs. Am J Respir Crit Care Med. 2019 11 15; 200(10):1234-1245. Liu A, Park JH, Zhang X, Sugita S, Naito Y, Lee JH, Kato H, Hao Q, Matthay MA, Lee JW. PMID: 31390880.
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    65. Lung inflammatory environments differentially alter mesenchymal stromal cell behavior. . 2019 12 01; 317(6):L823-L831. Abreu SC, Rolandsson Enes S, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ. PMID: 31553626.
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    68. A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs. Crit Care Med. 2019 09; 47(9):1184-1193. White DB, Carson S, Anderson W, Steingrub J, Bird G, Curtis JR, Matthay M, Peterson M, Buddadhumaruk P, Shields AM, Ernecoff N, Shotsberger K, Weissfeld L, Chang CH, Pike F, Lo B, Hough CL. PMID: 31162200.
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    70. The Continued Need for Clinical Trials in Deceased Organ Donor Management. Transplantation. 2019 07; 103(7):1298-1299. Niemann CU, Matthay MA, Ware LB. PMID: 30399123.
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    75. Is a Part Better than the Whole for Cell-based Therapy for Acute Respiratory Distress Syndrome? Anesthesiology. 2019 May; 130(5):683-685. Lee JW, Matthay MA. PMID: 30870157.
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    77. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 04; 7(4):e14. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. PMID: 30926051.
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    80. Could Decisions to Limit Treatment Contribute to Mortality Differences between Patients with Different Presepsis Trajectories? Ann Am Thorac Soc. 2019 04; 16(4):522. Block BL, Matthay M. PMID: 30495973.
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    81. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatr Crit Care Med. 2019 04; 20(4):323-331. Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. PMID: 30672838.
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    83. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019 03 14; 5(1):18. Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. PMID: 30872586.
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    88. Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2019 01 15; 199(2):181-189. Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A. PMID: 30114376.
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    89. ECMO in severe acute respiratory distress syndrome. Lancet Respir Med. 2019 02; 7(2):106-108. Matthay MA. PMID: 30642777.
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    90. Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma. Am J Respir Crit Care Med. 2019 01 01; 199(1):62-70. Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB. PMID: 30067389.
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    92. Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12353-E12362. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL. PMID: 30482864.
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    98. Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure. Pediatr Crit Care Med. 2018 10; 19(10):930-938. Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H. PMID: 30095747.
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    99. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N Engl J Med. 2018 08 30; 379(9):884-887. Mi MY, Matthay MA, Morris AH. PMID: 30157406.
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    127. Exosome-based Therapy for Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2018 01 01; 197(1):10-12. Matthay MA, Abman SH. PMID: 28957642.
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    128. Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania. Front Pediatr. 2017; 5:278. Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay MA, Reynolds T. PMID: 29312910.
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    129. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Am J Respir Cell Mol Biol. 2017 12; 57(6):711-720. Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C. PMID: 28708422.
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    130. ENaCs as Both Effectors and Regulators of MiRNAs in Lung Epithelial Development and Regeneration. Cell Physiol Biochem. 2017; 44(3):1120-1132. Ding Y, Zhao R, Zhao X, Matthay MA, Nie HG, Ji HL. PMID: 29179210.
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    131. Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury. Basic Science and Clinical Implications. Am J Respir Crit Care Med. 2017 11 15; 196(10):1234-1236. Matthay MA. PMID: 28640648.
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    132. Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats. J Heart Lung Transplant. 2018 06; 37(6):782-791. Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay MA, Blanch L, Artigas A. PMID: 29229270.
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    133. Cytokine Profiles of Severe Influenza Virus-Related Complications in Children. Front Immunol. 2017; 8:1423. Fiore-Gartland A, Panoskaltsis-Mortari A, Agan AA, Mistry AJ, Thomas PG, Matthay MA, Hertz T, Randolph AG. PMID: 29163498.
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    134. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". . 2017 11 01; 313(5):L966-L967. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. PMID: 29109110.
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    135. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. PMID: 28340238.
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    136. Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries. Trauma Surg Acute Care Open. 2017; 2(1):e000121. Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS. PMID: 29766112.
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    137. Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value. Am J Respir Crit Care Med. 2017 08 01; 196(3):266-273. Laffey JG, Matthay MA. PMID: 28306336.
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    138. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. PMID: 28737769.
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    139. Epithelial Sodium Channel-a Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction. Front Immunol. 2017; 8:842. Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R. PMID: 28785264.
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    140. Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies. Chest. 2017 07; 152(1):1-3. Crouser ED, Matthay MA. PMID: 28693760.
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    141. Inhalation therapies in acute respiratory distress syndrome. Ann Transl Med. 2017 Jul; 5(14):293. Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay MA. PMID: 28828368.
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    143. Lung Injury Etiology and Other Factors Influencing the Relationship Between Dead-Space Fraction and Mortality in ARDS. Respir Care. 2017 Oct; 62(10):1241-1248. Kallet RH, Zhuo H, Ho K, Lipnick MS, Gomez A, Matthay MA. PMID: 28611227.
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    144. External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Intensive Care Med. 2017 Aug; 43(8):1123-1131. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB. PMID: 28593401.
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    145. Clinical trials in acute respiratory distress syndrome: challenges and opportunities. Lancet Respir Med. 2017 06; 5(6):524-534. Matthay MA, McAuley DF, Ware LB. PMID: 28664851.
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    146. Pulmonary toxicity of e-cigarettes. . 2017 08 01; 313(2):L193-L206. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. PMID: 28522559.
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    148. Understanding blood gas analysis. Intensive Care Med. 2018 01; 44(1):91-93. Gattinoni L, Pesenti A, Matthay M. PMID: 28497267.
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    149. Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol. Trials. 2017 05 11; 18(1):214. Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF. PMID: 28494790.
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    150. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 07; 57(7):1684-1690. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL. PMID: 28470756.
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    151. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):798-805. Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE. PMID: 28240689.
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    152. Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):858-866. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A. PMID: 28248715.
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    153. Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. PLoS One. 2017; 12(4):e0175130. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC. PMID: 28419100.
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    154. Signals of vagal circuits engaging with AKT1 in a7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. Cell Discov. 2017; 3:17009. Zhao C, Yang X, Su EM, Huang Y, Li L, Matthay MA, Su X. PMID: 28529765.
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    156. Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset. . 2017 05 01; 312(5):L703-L709. Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay MA. PMID: 28258106.
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    158. Protein biomarkers associated with primary graft dysfunction following lung transplantation. . 2017 04 01; 312(4):L531-L541. Hamilton BC, Kukreja J, Ware LB, Matthay MA. PMID: 28130262.
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    159. Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis. Stem Cells. 2017 02; 35(2):316-324. Matthay MA, Pati S, Lee JW. PMID: 27888550.
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    160. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2017 Jan; 112(1):56-63. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, . PMID: 28001313.
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    161. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care. 2016 11 17; 20(1):372. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM. PMID: 27852290.
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    162. Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful? JAMA Intern Med. 2016 11 01; 176(11):1660-1661. Moore PK, Matthay MA. PMID: 27599363.
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    163. Clinical, Radiographic, Physiologic, and Biologic Measurements to Facilitate Personalized Medicine for ARDS. Chest. 2016 11; 150(5):989-990. Matthay MA, Beitler JR. PMID: 27832890.
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    164. What drives neutrophils to the alveoli in ARDS? Thorax. 2017 01; 72(1):1-3. Zemans RL, Matthay MA. PMID: 27974631.
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    165. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. PMID: 27716790.
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    166. Challenges in predicting which patients will develop ARDS. Lancet Respir Med. 2016 11; 4(11):847-848. Matthay MA. PMID: 27717862.
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    167. Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 10; 17(10):917-923. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR. PMID: 27513687.
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    168. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 10; 17(10):907-916. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A. PMID: 27487912.
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    170. Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Sep; 44(9):1735-43. Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay MA, Thompson BT, Bajwa EK, . PMID: 27525994.
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    171. The authors reply. Crit Care Med. 2016 08; 44(8):e769-70. Kangelaris KN, Ware LB, Matthay MA, Calfee CS. PMID: 27428148.
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    173. miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ. PMID: 27362652.
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    174. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay MA, Thompson BT, Talmor D. PMID: 27342819.
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    175. A new experimental model of acid- and endotoxin-induced acute lung injury in rats. . 2016 08 01; 311(2):L229-37. Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L, Stelmakh O, Blanch L, Serrano-Mollar A, Matthay MA, Artigas A. PMID: 27317688.
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    177. Sepsis: pathophysiology and clinical management. BMJ. 2016 05 23; 353:i1585. Gotts JE, Matthay MA. PMID: 27217054.
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    178. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016 May 23; 20(1):151. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, . PMID: 27215212.
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    179. Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 May 15; 193(10):1143-50. Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS. PMID: 26681363.
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    180. Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS. Stem Cells. 2016 08; 34(8):2210-23. Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD. PMID: 27059413.
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    183. Diagnostic workup for ARDS patients. Intensive Care Med. 2016 May; 42(5):674-685. Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU. PMID: 27007111.
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    184. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3621-6. Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS. PMID: 26976597.
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    186. Acute Hypoxemic Respiratory Failure after Large-Volume Thoracentesis. Mechanisms of Pleural Fluid Formation and Reexpansion Pulmonary Edema. Ann Am Thorac Soc. 2016 Mar; 13(3):438-43. Walter JM, Matthay MA, Gillespie CT, Corbridge T. PMID: 26963356.
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    187. New Strategies for Effective Therapeutics in Critically Ill Patients. JAMA. 2016 Feb 23; 315(8):747-8. Matthay MA, Liu KD. PMID: 26903328.
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    188. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 12; 71(12):1130-1136. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS. PMID: 26839359.
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    189. Acute cor pulmonale and the acute respiratory distress syndrome. Intensive Care Med. 2016 May; 42(5):934-936. Guérin C, Matthay MA. PMID: 26759013.
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    190. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Jan; 44(1):120-9. Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS. PMID: 26474112.
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    194. Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):324-36. Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW. PMID: 26067592.
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    199. Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 01; 195(1):87-95. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D. PMID: 26002979.
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    201. Sedation protocol for critically ill pediatric patients--reply. JAMA. 2015 May 05; 313(17):1754-5. Curley MA, Wypij D, Matthay MA. PMID: 25942731.
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    315. Acute lung failure. Semin Respir Crit Care Med. 2011 Oct; 32(5):607-25. Mac Sweeney R, McAuley DF, Matthay MA. PMID: 21989697.
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    375. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med. 2010 Jan; 36(1):157-63. Sapru A, Curley MA, Brady S, Matthay MA, Flori H. PMID: 19855955.
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    379. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. PMID: 19721001.
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    382. NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med. 2009 Nov 15; 180(10):972-81. Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C. PMID: 19661248.
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    387. Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Pediatr Crit Care Med. 2009 May; 10(3):297-302. Church GD, Matthay MA, Liu K, Milet M, Flori HR. PMID: 19307809.
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    388. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol. 2009 May; 44(5):457-63. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD. PMID: 19382217.
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    389. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology. 2009 May; 110(5):1086-91. Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay MA, Wiener-Kronish J. PMID: 19387177.
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    456. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):480-90. Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM. PMID: 17099140.
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