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Michael Matthay, MD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-353-1206
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityA.B.1969English
    University of PennsylvaniaM.D.1973School of Medicine
    University of Colorado Medical CenterInternship and Residency1976Internal Medicine
    University of California, San FranciscoFellowship1978Pulmonary DIvision
    University of California, San FranciscoFellowship1979Cardiovascular Research Institute

    Collapse Research 
    Collapse Research Activities and Funding
    Prevention and Early Treatment of Acute Lung Injury
    NIH/NHLBI U01HL123004Jun 17, 2014 - Apr 30, 2021
    Role: Principal Investigator
    Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury
    NIH/NHLBI U01HL108713Sep 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH N01HR56166-16-0-1Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH N01HR56166-16-0-4Sep 30, 2005 - Jul 15, 2013
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-14-0-1Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - SAILS Protocol
    NIH/NHLBI N01HR56166-14-0-4Sep 30, 2005 - Oct 31, 2012
    Role: Principal Investigator
    ARDS - ALTA Protocol
    NIH/NHLBI N01HR56166Sep 30, 2005 - Sep 29, 2012
    Role: Co-Principal Investigator
    ARDS - EDEN Protocol
    NIH/NHLBI N01HR56166-6-0-3Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-7-0-1Sep 30, 2005 - Sep 29, 2012
    Role: Principal Investigator
    Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome
    NIH/NHLBI N01HR56166-9-0-1Sep 30, 2005 - Nov 30, 2011
    Role: Principal Investigator
    Transfusion and Lung Injury
    NIH/NHLBI P50HL081027Sep 30, 2005 - Aug 31, 2011
    Role: Co-Investigator
    SCCOR in translational research in Acute Lung Injury
    NIH/NHLBI P50HL074005Sep 30, 2003 - Jun 30, 2010
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Co-Investigator
    Resolution of Clinical Lung Injury
    NIH/NHLBI R37HL051856Apr 1, 1996 - Mar 31, 2016
    Role: Principal Investigator
    RESOLUTION OF CLINICAL LUNG INJURY
    NIH/NHLBI R01HL051856Apr 1, 1996 - Mar 31, 2006
    Role: Principal Investigator
    CCTG CLINICAL NETWORK FOR ARDS TREATMENT--CRITICAL CARE
    NIH/NHLBI N01HR046059Sep 30, 1994 - Dec 31, 2003
    Role: Principal Investigator
    Lung Fluid Balance and Mesenchymal Stem Cells
    NIH/NHLBI R01HL051854Apr 8, 1994 - Jun 30, 2013
    Role: Principal Investigator
    ALVEOLAR EPITHELIAL LIQUID AND PROTEIN CLEARANCE
    NIH/NHLBI R01HL040626Jun 1, 1988 - Nov 30, 1989
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    PATHOPHYSIOLOGY OF LUNG LIQUID &PROTEIN EXCHANGE
    NIH P01HL025816Jun 1, 1980 - May 31, 1994
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Websites
    Collapse In The News
    Collapse Featured Presentations
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay M, Kleinman SH, Brambilla D, Murphy EL. Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Crit Care Med. 2018 04; 46(4):577-585. PMID: 29300236.
      View in: PubMed
    2. Gotts JE, Matthay M. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 Feb 01; 197(3):280-281. PMID: 29072926.
      View in: PubMed
    3. Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S. Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. J Trauma Acute Care Surg. 2018 Feb; 84(2):245-256. PMID: 29251710.
      View in: PubMed
    4. Hamilton BCS, Dincheva GR, Zhuo H, Golden JA, Brzezinski M, Singer JP, Matthay M, Kukreja J. Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction. Clin Transplant. 2018 Jan 29. PMID: 29377268.
      View in: PubMed
    5. Matthay M, Abman SH. Exosome-based Therapy for Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2018 Jan 01; 197(1):10-12. PMID: 28957642.
      View in: PubMed
    6. Schell-Chaple HM, Liu KD, Matthay M, Puntillo KA. Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System. Am J Crit Care. 2018 Jan; 27(1):43-50. PMID: 29292274.
      View in: PubMed
    7. Kortz TB, Sawe HR, Murray B, Enanoria W, Matthay M, Reynolds T. Clinical Presentation and Outcomes among Children with Sepsis Presenting to a Public Tertiary Hospital in Tanzania. Front Pediatr. 2017; 5:278. PMID: 29312910.
      View in: PubMed
    8. Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay M, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C. The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations. Am J Respir Cell Mol Biol. 2017 12; 57(6):711-720. PMID: 28708422.
      View in: PubMed
    9. Matthay M. Extracellular Vesicle Transfer from Mesenchymal Stromal Cells Modulates Macrophage Function in Acute Lung Injury. Basic Science and Clinical Implications. Am J Respir Crit Care Med. 2017 11 15; 196(10):1234-1236. PMID: 28640648.
      View in: PubMed
    10. Guillamat-Prats R, Puig F, Camprubí-Rimblas M, Herrero R, Serrano-Mollar A, Gómez MN, Tijero J, Matthay M, Blanch L, Artigas A. Intratracheal instillation of alveolar type II cells enhances recovery from acute lung injury in rats. J Heart Lung Transplant. 2017 Nov 08. PMID: 29229270.
      View in: PubMed
    11. Chun LF, Moazed F, Calfee CS, Matthay M, Gotts JE. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L966-L967. PMID: 29109110.
      View in: PubMed
    12. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay M. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039. PMID: 28340238.
      View in: PubMed
    13. Laffey JG, Matthay M. Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value. Am J Respir Crit Care Med. 2017 Aug 01; 196(3):266-273. PMID: 28306336.
      View in: PubMed
    14. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay M, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. PMID: 28737769.
      View in: PubMed
    15. Artigas A, Camprubí-Rimblas M, Tantinyà N, Bringué J, Guillamat-Prats R, Matthay M. Inhalation therapies in acute respiratory distress syndrome. Ann Transl Med. 2017 Jul; 5(14):293. PMID: 28828368.
      View in: PubMed
    16. Schell-Chaple HM, Liu KD, Matthay M, Sessler DI, Puntillo KA. Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Crit Care Med. 2017 Jul; 45(7):1199-1207. PMID: 28319467.
      View in: PubMed
    17. Crouser ED, Matthay M. Endothelial Damage During Septic Shock: Significance and Implications for Future Therapies. Chest. 2017 Jul; 152(1):1-3. PMID: 28693760.
      View in: PubMed
    18. Kallet RH, Zhuo H, Ho K, Lipnick MS, Gomez A, Matthay M. Lung Injury Etiology and Other Factors Influencing the Relationship Between Dead-Space Fraction and Mortality in ARDS. Respir Care. 2017 Oct; 62(10):1241-1248. PMID: 28611227.
      View in: PubMed
    19. Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay M, Calfee CS, Koyama T, Ware LB. External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Intensive Care Med. 2017 Aug; 43(8):1123-1131. PMID: 28593401.
      View in: PubMed
    20. Matthay M, McAuley DF, Ware LB. Clinical trials in acute respiratory distress syndrome: challenges and opportunities. Lancet Respir Med. 2017 06; 5(6):524-534. PMID: 28664851.
      View in: PubMed
    21. Chun LF, Moazed F, Calfee CS, Matthay M, Gotts JE. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 01; 313(2):L193-L206. PMID: 28522559.
      View in: PubMed
    22. McAuley DF, Cross LM, Hamid U, Gardner E, Elborn JS, Cullen KM, Dushianthan A, Grocott MP, Matthay M, O'Kane CM. Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Respir Med. 2017 06; 5(6):484-491. PMID: 28526233.
      View in: PubMed
    23. Cross LJM, O'Kane CM, McDowell C, Elborn JJ, Matthay M, McAuley DF. Erratum to: Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction - a randomised placebo-controlled trial (KARE): study protocol. Trials. 2017 May 11; 18(1):214. PMID: 28494790.
      View in: PubMed
    24. Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay M, Levitt JE. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):798-805. PMID: 28240689.
      View in: PubMed
    25. Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay M, Sapru A. Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May; 45(5):858-866. PMID: 28248715.
      View in: PubMed
    26. Huppert LA, Matthay M. Alveolar Fluid Clearance in Pathologically Relevant Conditions: In Vitro and In Vivo Models of Acute Respiratory Distress Syndrome. Front Immunol. 2017; 8:371. PMID: 28439268.
      View in: PubMed
    27. Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay M. Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset. Am J Physiol Lung Cell Mol Physiol. 2017 May 01; 312(5):L703-L709. PMID: 28258106.
      View in: PubMed
    28. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay M. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. Am J Physiol Lung Cell Mol Physiol. 2017 May 01; 312(5):L579-L585. PMID: 28213470.
      View in: PubMed
    29. Matthay M, Pati S, Lee JW. Concise Review: Mesenchymal Stem (Stromal) Cells: Biology and Preclinical Evidence for Therapeutic Potential for Organ Dysfunction Following Trauma or Sepsis. Stem Cells. 2017 02; 35(2):316-324. PMID: 27888550.
      View in: PubMed
    30. Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay M, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Crit Care. 2016 11 17; 20(1):372. PMID: 27852290.
      View in: PubMed
    31. Matthay M, Beitler JR. Clinical, Radiographic, Physiologic, and Biologic Measurements to Facilitate Personalized Medicine for ARDS. Chest. 2016 Nov; 150(5):989-990. PMID: 27832890.
      View in: PubMed
    32. Moore PK, Matthay M. Overnight Extubation in Patients With Mechanical Ventilation: Is It Harmful? JAMA Intern Med. 2016 Nov 01; 176(11):1660-1661. PMID: 27599363.
      View in: PubMed
    33. Xu X, Greenland JR, Gotts JE, Matthay M, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501. PMID: 27716790.
      View in: PubMed
    34. Matthay M. Challenges in predicting which patients will develop ARDS. Lancet Respir Med. 2016 11; 4(11):847-848. PMID: 27717862.
      View in: PubMed
    35. Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay M, Flori HR. Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):917-923. PMID: 27513687.
      View in: PubMed
    36. Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay M, Sapru A. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):907-916. PMID: 27487912.
      View in: PubMed
    37. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay M, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI Insight. 2016 Sep 08; 1(14):e87871. PMID: 27699235.
      View in: PubMed
    38. Alladina JW, Levy SD, Hibbert KA, Januzzi JL, Harris RS, Matthay M, Thompson BT, Bajwa EK. Plasma Concentrations of Soluble Suppression of Tumorigenicity-2 and Interleukin-6 Are Predictive of Successful Liberation From Mechanical Ventilation in Patients With the Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Sep; 44(9):1735-43. PMID: 27525994; PMCID: PMC4988326 [Available on 09/01/17].
    39. Kangelaris KN, Ware LB, Matthay M, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e771. PMID: 27428150.
      View in: PubMed
    40. Kangelaris KN, Ware LB, Matthay M, Calfee CS. The authors reply. Crit Care Med. 2016 Aug; 44(8):e769-70. PMID: 27428148.
      View in: PubMed
    41. Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay M, Kukreja J, Erle DJ, Collard HR, Wolters PJ. miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis. PLoS One. 2016; 11(6):e0158367. PMID: 27362652; PMCID: PMC4928999.
    42. Beitler JR, Sands SA, Loring SH, Owens RL, Malhotra A, Spragg RG, Matthay M, Thompson BT, Talmor D. Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. Intensive Care Med. 2016 Sep; 42(9):1427-36. PMID: 27342819; PMCID: PMC4992404 [Available on 09/01/17].
    43. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay M, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 06; 80(6):989-97. PMID: 26881489.
      View in: PubMed
    44. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay M. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016 May 23; 20(1):151. PMID: 27215212; PMCID: PMC4876559.
    45. Gotts JE, Matthay M. Sepsis: pathophysiology and clinical management. BMJ. 2016 05 23; 353:i1585. PMID: 27217054.
      View in: PubMed
    46. Ware LB, Zhao Z, Koyama T, May AK, Matthay M, Lurmann FW, Balmes JR, Calfee CS. Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 May 15; 193(10):1143-50. PMID: 26681363; PMCID: PMC4872663 [Available on 05/15/17].
    47. Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay M, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD. Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS. Stem Cells. 2016 08; 34(8):2210-23. PMID: 27059413; PMCID: PMC4982045.
    48. Bhattacharya M, Kallet RH, Ware LB, Matthay M. Negative-Pressure Pulmonary Edema. Chest. 2016 Oct; 150(4):927-933. PMID: 27063348.
      View in: PubMed
    49. Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay M, Meduri GU. Diagnostic workup for ARDS patients. Intensive Care Med. 2016 May; 42(5):674-685. PMID: 27007111.
      View in: PubMed
    50. Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay M, Peiris JS. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3621-6. PMID: 26976597; PMCID: PMC4822574.
    51. Matthay M, Liu KD. New Strategies for Effective Therapeutics in Critically Ill Patients. JAMA. 2016 Feb 23; 315(8):747-8. PMID: 26903328.
      View in: PubMed
    52. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay M, McAuley DF, Calfee CS. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 12; 71(12):1130-1136. PMID: 26839359.
      View in: PubMed
    53. Guérin C, Matthay M. Acute cor pulmonale and the acute respiratory distress syndrome. Intensive Care Med. 2016 May; 42(5):934-936. PMID: 26759013.
      View in: PubMed
    54. Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay M, Calfee CS. Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med. 2016 Jan; 44(1):120-9. PMID: 26474112; PMCID: PMC4774861 [Available on 01/01/17].
    55. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay M, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015 Dec 14; 19:435. PMID: 26652251; PMCID: PMC4699329.
    56. Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay M, Sapru A. Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 01; 310(3):L224-31. PMID: 26660787.
      View in: PubMed
    57. Calfee CS, Matthay M, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit Care Med. 2015 Sep; 43(9):1790-7. PMID: 26010690; PMCID: PMC4737582.
    58. Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay M, Lee JW. Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Am J Respir Crit Care Med. 2015 Aug 01; 192(3):324-36. PMID: 26067592; PMCID: PMC4584251.
    59. Matthay M, Ware LB. Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology. Am J Respir Crit Care Med. 2015 Jul 15; 192(2):124-5. PMID: 26177166.
      View in: PubMed
    60. Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay M. Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. J Immunol. 2015 Aug 01; 195(3):875-81. PMID: 26116507.
      View in: PubMed
    61. Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay M, Mehta D, Reddy NM, Reddy SP. Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L414-24. PMID: 26071555; PMCID: PMC4538236.
    62. Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay M, Ware LB. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Chest. 2015 Jun; 147(6):1539-1548. PMID: 26033126; PMCID: PMC4451708.
    63. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay M, Sheppard D. Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 01; 195(1):87-95. PMID: 26002979; PMCID: PMC4475475.
    64. Matthay M. Saving lives with high-flow nasal oxygen. N Engl J Med. 2015 Jun 04; 372(23):2225-6. PMID: 25982042.
      View in: PubMed
    65. Beitler JR, Thompson BT, Matthay M, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35. PMID: 25738857; PMCID: PMC4400228.
    66. Wilson J, McKenna D, Liu KD, Matthay M. Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply. Lancet Respir Med. 2015 Apr; 3(4):e12-3. PMID: 25890655.
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    67. Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay M, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1102-13. PMID: 25795726; PMCID: PMC4451399.
    68. Matthay M. Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S54-7. PMID: 25830837; PMCID: PMC4430975.
    69. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay M. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574. PMID: 25708422.
      View in: PubMed
    70. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay M, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135.
    71. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay M. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8. PMID: 25643902; PMCID: PMC4500527.
    72. Schell-Chaple HM, Puntillo KA, Matthay M, Liu KD. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan; 24(1):15-23. PMID: 25554550; PMCID: PMC4464553.
    73. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay M, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958; PMCID: PMC4312207.
    74. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay M. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32. PMID: 25529339; PMCID: PMC4297579.
    75. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay M, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517.
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    83. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay M, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48. PMID: 25085625; PMCID: PMC4166786.
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    90. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay M, Enkhbaatar P. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax. 2014 Sep; 69(9):819-25. PMID: 24891325; PMCID: PMC4284068.
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    94. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 05; 370(23):2191-200. PMID: 24835849; PMCID: PMC4241052.
    95. Wilson JG, Matthay M. Mechanical ventilation in acute hypoxemic respiratory failure: a review of new strategies for the practicing hospitalist. J Hosp Med. 2014 Jul; 9(7):469-75. PMID: 24733692; PMCID: PMC4139286.
    96. Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay M, Clerici C. Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 01; 306(11):L975-85. PMID: 24682451; PMCID: PMC4042188.
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    98. Liles WC, Matthay M, Dos Santos CC, Weiss DJ, Stewart DJ. Mesenchymal stromal (stem) cell therapy: an emerging immunomodulatory strategy for the adjunctive treatment of sepsis. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):363-4. PMID: 24484339.
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    143. Cha SI, Chang CS, Kim EK, Lee JW, Matthay M, Golden JA, Elicker BM, Jones K, Collard HR, Wolters PJ. Lung mast cell density defines a subpopulation of patients with idiopathic pulmonary fibrosis. Histopathology. 2012 Jul; 61(1):98-106. PMID: 22394225; PMCID: PMC3371307.
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    157. Rokkam D, Lafemina MJ, Lee JW, Matthay M, Frank JA. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Am J Pathol. 2011 Sep; 179(3):1081-7. PMID: 21741940; PMCID: PMC3157178.
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    159. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay M, Liu KD. Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Ann Intensive Care. 2011 Jun 13; 1(1):18. PMID: 21906356; PMCID: PMC3224453.
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    161. Flori HR, Church G, Liu KD, Gildengorin G, Matthay M. Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract. 2011; 2011:854142. PMID: 21687578; PMCID: PMC3114079.
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    163. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay M, Slutsky AS, Kuebler WM. An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol. 2011 May; 44(5):725-38. PMID: 21531958.
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    165. Seeley EJ, McAuley DF, Eisner M, Miletin M, Zhuo H, Matthay M, Kallet RH. Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury. Respir Res. 2011 Apr 22; 12:52. PMID: 21513532; PMCID: PMC3105946.
    166. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay M, Chapman HA, Wolters PJ. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L71-8. PMID: 21498628; PMCID: PMC3129898.
    167. Cross LJ, Matthay M. Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury. Crit Care Clin. 2011 Apr; 27(2):355-77. PMID: 21440206; PMCID: PMC3073651.
    168. Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay M. Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med. 2011 Apr; 39(4):711-7. PMID: 21283009; PMCID: PMC3260884.
    169. Calfee CS, Matthay M, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ. Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1660-5. PMID: 21471091; PMCID: PMC3136993.
    170. Rice TW, Ware LB, Haponik EF, Chiles C, Wheeler AP, Bernard GR, Steingrub JS, Hite RD, Matthay M, Wright P, Ely EW. Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care. 2011; 15(2):R86. PMID: 21385351; PMCID: PMC3219344.
    171. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay M. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011 Jul; 60(7):619-32. PMID: 21301926; PMCID: PMC3116128.
    172. Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay M. Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization. J Heart Lung Transplant. 2011 Feb; 30(2):211-7. PMID: 20869266; PMCID: PMC3019270.
    173. Rey MM, Ware LB, Matthay M, Bernard GR, McGuire AL, Caplan AL, Halpern SD. Informed consent in research to improve the number and quality of deceased donor organs. Crit Care Med. 2011 Feb; 39(2):280-3. PMID: 20975549; PMCID: PMC3717371.
    174. Yamakawa N, Uchida T, Matthay M, Makita K. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Apr; 300(4):L516-25. PMID: 21257730; PMCID: PMC3075094.
    175. Finigan JH, Faress JA, Wilkinson E, Mishra RS, Nethery DE, Wyler D, Shatat M, Ware LB, Matthay M, Mason R, Silver RF, Kern JA. Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. J Biol Chem. 2011 Mar 25; 286(12):10660-70. PMID: 21247898; PMCID: PMC3060517.
    176. Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay M, Benowitz NL, Calfee CS. Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients. Crit Care Med. 2011 Jan; 39(1):40-5. PMID: 20935560; PMCID: PMC3148017.
    177. Matthay M, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 2011; 6:147-63. PMID: 20936936; PMCID: PMC3108259.
    178. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay M. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010 Dec; 28(12):2229-38. PMID: 20945332; PMCID: PMC3293245.
    179. Levitt JE, Matthay M. The utility of clinical predictors of acute lung injury: towards prevention and earlier recognition. Expert Rev Respir Med. 2010 Dec; 4(6):785-97. PMID: 21128753; PMCID: PMC3044497.
    180. Cribbs SK, Matthay M, Martin GS. Stem cells in sepsis and acute lung injury. Crit Care Med. 2010 Dec; 38(12):2379-85. PMID: 20838330; PMCID: PMC3677751.
    181. Lee JS, Su X, Rackley C, Matthay M, Gupta N. Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken). 2011 Jan; 294(1):165-72. PMID: 21157927; PMCID: PMC3072226.
    182. Singer M, Matthay M. Thinking outside the box: Introduction. Crit Care Med. 2010 Oct; 38(10 Suppl):S511. PMID: 21164389.
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    184. Matthay M, Goolaerts A, Howard JP, Lee JW. Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med. 2010 Oct; 38(10 Suppl):S569-73. PMID: 21164399; PMCID: PMC3580946.
    185. Brown LM, Kallet RH, Matthay M, Dicker RA. The influence of race on the development of acute lung injury in trauma patients. Am J Surg. 2011 Apr; 201(4):486-91. PMID: 20832050; PMCID: PMC3006033.
    186. Looney MR, Gilliss BM, Matthay M. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. PMID: 20601870.
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    187. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay M, Liu KD. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med. 2010 Sep; 38(9):1845-51. PMID: 20581666.
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    188. McAuley DF, Brown LM, Matthay M. Assessing the quantity of pulmonary edema in critically ill children. Crit Care. 2010; 14(4):189. PMID: 20804574; PMCID: PMC2945115.
    189. Matthay M. Advances and challenges in translating stem cell therapies for clinical diseases. Transl Res. 2010 Sep; 156(3):107-11. PMID: 20801407.
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    190. Bastarache JA, Ong T, Matthay M, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care. 2011 Jun; 26(3):249-56. PMID: 20688464; PMCID: PMC2982881.
    191. Diaz JV, Brower R, Calfee CS, Matthay M. Therapeutic strategies for severe acute lung injury. Crit Care Med. 2010 Aug; 38(8):1644-50. PMID: 20562704; PMCID: PMC4526259.
    192. Johnson ER, Matthay M. Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010 Aug; 23(4):243-52. PMID: 20073554; PMCID: PMC3133560.
    193. Matthay M, Jayr C. Acute respiratory distress syndrome after surgery: can the risk be decreased? Anesth Analg. 2010 Aug; 111(2):268-9. PMID: 20664090.
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    194. Fang X, Neyrinck AP, Matthay M, Lee JW. Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1. J Biol Chem. 2010 Aug 20; 285(34):26211-22. PMID: 20554518; PMCID: PMC2924032.
    195. Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay M, Wong HR. Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med. 2010 Jun; 38(6):1436-41. PMID: 20386309; PMCID: PMC3348116.
    196. Cooke CR, Erickson SE, Watkins TR, Matthay M, Hudson LD, Rubenfeld GD. Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med. 2010 Jun; 38(6):1450-7. PMID: 20386308; PMCID: PMC3799957.
    197. Matthay M, Idell S. Update on acute lung injury and critical care medicine 2009. Am J Respir Crit Care Med. 2010 May 15; 181(10):1027-32. PMID: 20460547; PMCID: PMC3269230.
    198. Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay M, May AK, Ware LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 2010 May; 68(5):1121-7. PMID: 20038857; PMCID: PMC3347639.
    199. Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay M, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L3-7. PMID: 20418386; PMCID: PMC2904092.
    200. Ballard PL, Lee JW, Fang X, Chapin C, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay M. Regulated gene expression in cultured type II cells of adult human lung. Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L36-50. PMID: 20382749; PMCID: PMC2904098.
    201. Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay M, Carles M, Pittet JF. Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. Thorax. 2010 Apr; 65(4):346-53. PMID: 20388761; PMCID: PMC3118552.
    202. Diep BA, Chan L, Tattevin P, Kajikawa O, Martin TR, Basuino L, Mai TT, Marbach H, Braughton KR, Whitney AR, Gardner DJ, Fan X, Tseng CW, Liu GY, Badiou C, Etienne J, Lina G, Matthay M, DeLeo FR, Chambers HF. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5587-92. PMID: 20231457; PMCID: PMC2851770.
    203. Calfee CS, Matthay M. Clinical immunology: Culprits with evolutionary ties. Nature. 2010 Mar 04; 464(7285):41-2. PMID: 20203598; PMCID: PMC2857339.
    204. Brown LM, Matthay M. Measuring the quantity of pulmonary edema in clinical lung injury. Crit Care Med. 2010 Jan; 38(1):312-4. PMID: 20023478.
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    205. Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay M, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB. Thirty years of critical care medicine. Crit Care. 2010; 14(3):311. PMID: 20550727; PMCID: PMC2911692.
    206. Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay M, Pittet JF. Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2010 Feb 12; 285(7):4278-90. PMID: 19996317; PMCID: PMC2836032.
    207. Abman SH, Matthay M. Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia: delivering the secretome. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1039-41. PMID: 19923401.
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    208. Su X, Matthay M, Malik AB. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol. 2010 Jan 01; 184(1):401-10. PMID: 19949071; PMCID: PMC2877486.
    209. Katayama M, Ishizaka A, Sakamoto M, Fujishima S, Sekiguchi K, Asano K, Betsuyaku T, Kotani T, Ware LB, Matthay M, Hashimoto S. Laminin gamma2 fragments are increased in the circulation of patients with early phase acute lung injury. Intensive Care Med. 2010 Mar; 36(3):479-86. PMID: 19940975; PMCID: PMC2820224.
    210. Reel B, Oishi PE, Hsu JH, Gildengorin G, Matthay M, Fineman JR, Flori H. Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury. Pediatr Pulmonol. 2009 Nov; 44(11):1118-24. PMID: 19830720; PMCID: PMC4427345.
    211. Ware LB, Koyama T, Billheimer DD, Wu W, Bernard GR, Thompson BT, Brower RG, Standiford TJ, Martin TR, Matthay M. Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest. 2010 Feb; 137(2):288-96. PMID: 19858233; PMCID: PMC2816641.
    212. Sapru A, Curley MA, Brady S, Matthay M, Flori H. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Intensive Care Med. 2010 Jan; 36(1):157-63. PMID: 19855955; PMCID: PMC2807603.
    213. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay M. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
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    215. Lee JW, Fang X, Gupta N, Serikov V, Matthay M. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16357-62. PMID: 19721001.
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    217. Colucci G, Domenighetti G, Della Bruna R, Bonilla J, Limoni C, Matthay M, Martin TR. Comparison of two non-bronchoscopic methods for evaluating inflammation in patients with acute hypoxaemic respiratory failure. Crit Care. 2009; 13(4):R134. PMID: 19671148; PMCID: PMC2750192.
    218. Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay M, Krause KH, Barazzone Argiroffo C. NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med. 2009 Nov 15; 180(10):972-81. PMID: 19661248; PMCID: PMC2778156.
    219. Brown LM, Liu KD, Matthay M. Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L547-58. PMID: 19617309; PMCID: PMC2770794.
    220. McAuley DF, Matthay M. Clara cell protein CC16. A new lung epithelial biomarker for acute lung injury. Chest. 2009 Jun; 135(6):1408-1410. PMID: 19497890.
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    221. Liu KD, Looney MR, Matthay M. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. PMID: 19519935; PMCID: PMC2717421.
    222. Neyrinck AP, Liu KD, Howard JP, Matthay M. Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol. 2009 Oct; 158(4):1034-47. PMID: 19466992; PMCID: PMC2785525.
    223. Sapru A, Hansen H, Ajayi T, Brown R, Garcia O, Zhuo H, Wiemels J, Matthay M, Wiener-Kronish J. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Anesthesiology. 2009 May; 110(5):1086-91. PMID: 19387177; PMCID: PMC4127307.
    224. Church GD, Matthay M, Liu K, Milet M, Flori HR. Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Pediatr Crit Care Med. 2009 May; 10(3):297-302. PMID: 19307809; PMCID: PMC3586190.
    225. Erickson SE, Martin GS, Davis JL, Matthay M, Eisner MD. Recent trends in acute lung injury mortality: 1996-2005. Crit Care Med. 2009 May; 37(5):1574-9. PMID: 19325464; PMCID: PMC2696257.
    226. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay M, Liu KD. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol. 2009 May; 44(5):457-63. PMID: 19382217.
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    227. Su X, Looney MR, Gupta N, Matthay M. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309; PMCID: PMC2711813.
    228. Su X, Matthay M. Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis. Anat Rec (Hoboken). 2009 Apr; 292(4):580-6. PMID: 19226616; PMCID: PMC3092500.
    229. Shyamsundar M, McKeown ST, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay M, Taggart CC, Backman JT, Elborn JS, McAuley DF. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1107-14. PMID: 19324974; PMCID: PMC2695496.
    230. Levitt JE, Gould MK, Ware LB, Matthay M. The pathogenetic and prognostic value of biologic markers in acute lung injury. J Intensive Care Med. 2009 May-Jun; 24(3):151-67. PMID: 19282296.
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    231. Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay M. Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure. Chest. 2009 Apr; 135(4):936-943. PMID: 19188549; PMCID: PMC2758305.
    232. Neyrinck AP, Matthay M. The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats. Crit Care Med. 2009 Feb; 37(2):776-7. PMID: 19325385.
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    233. Erickson SE, Shlipak MG, Martin GS, Wheeler AP, Ancukiewicz M, Matthay M, Eisner MD. Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med. 2009 Jan; 37(1):1-6. PMID: 19050621; PMCID: PMC2696263.
    234. Krupa A, Fudala R, Stankowska D, Loyd T, Allen TC, Matthay M, Gryczynski Z, Gryczynski I, Mettikolla YV, Kurdowska AK. Anti-chemokine autoantibody:chemokine immune complexes activate endothelial cells via IgG receptors. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):155-69. PMID: 19109244; PMCID: PMC2715905.
    235. Iles KE, Wright MM, Cole MP, Welty NE, Ware LB, Matthay M, Schopfer FJ, Baker PR, Agarwal A, Freeman BA. Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic Biol Med. 2009 Apr 01; 46(7):866-75. PMID: 19133325; PMCID: PMC3104854.
    236. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay M. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest. 2009 Feb; 135(2):269-275. PMID: 19017890; PMCID: PMC2714162.
    237. Ware LB, Matthay M. Beyond fishing: the role of discovery proteomics in mechanistic lung research. Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L12-3. PMID: 19011049; PMCID: PMC2636947.
    238. Glassberg AE, Luce JM, Matthay M. Reasons for nonenrollment in a clinical trial of acute lung injury. Chest. 2008 Oct; 134(4):719-23. PMID: 18689583; PMCID: PMC2789486.
    239. Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay M, Ware LB. Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med. 2009 Feb; 35(2):248-57. PMID: 18670758; PMCID: PMC2790376.
    240. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay M. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23. PMID: 18565951; PMCID: PMC2542435.
    241. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay M. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med. 2008 Jun; 36(6):1846-54. PMID: 18496381; PMCID: PMC2442403.
    242. Su X, Johansen M, Looney MR, Brown EJ, Matthay M. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. PMID: 18453616; PMCID: PMC2771449.
    243. Matthay M, Berthiaume Y. Novel molecular strategy to prevent pulmonary edema. Crit Care Med. 2008 May; 36(5):1671-3. PMID: 18448936; PMCID: PMC2765326.
    244. Matthay M. Measurement of extravascular lung water in patients with pulmonary edema. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1021-2. PMID: 18441090.
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    245. Liu KD, Matthay M. Protein C as a surrogate end-point for clinical trials of sepsis. Crit Care. 2008; 12(2):139. PMID: 18492215; PMCID: PMC2447596.
    246. Matthay M. Treatment of acute lung injury: clinical and experimental studies. Proc Am Thorac Soc. 2008 Apr 15; 5(3):297-9. PMID: 18403322.
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    247. Matthay M, Calfee CS. Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery. Chest. 2008 Apr; 133(4):833-5. PMID: 18398109.
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    248. McClintock D, Zhuo H, Wickersham N, Matthay M, Ware LB. Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit Care. 2008; 12(2):R41. PMID: 18358078; PMCID: PMC2447583.
    249. Matthay M, Lee J. Beta2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Thorax. 2008 Mar; 63(3):189-90. PMID: 18308954.
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    250. Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay M, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L874-81. PMID: 18310227; PMCID: PMC2764534.
    251. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay M, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res. 2008 Apr 11; 102(7):804-12. PMID: 18276918; PMCID: PMC2739091.
    252. Liu KD, Matthay M. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clin J Am Soc Nephrol. 2008 Mar; 3(2):578-86. PMID: 18199848.
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    253. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay M, Olman MA. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol. 2008 Jan 01; 180(1):637-46. PMID: 18097066; PMCID: PMC2789491.
    254. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay M. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007 Dec; 35(12):2755-61. PMID: 18074478; PMCID: PMC3293249.
    255. Popov BV, Serikov VB, Petrov NS, Izusova TV, Gupta N, Matthay M. Lung epithelial cells induce endodermal differentiation in mouse mesenchymal bone marrow stem cells by paracrine mechanism. Tissue Eng. 2007 Oct; 13(10):2441-50. PMID: 17630877.
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    256. Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay M. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med. 2007 Oct; 35(10):2243-50. PMID: 17944012; PMCID: PMC2765812.
    257. Looney MR, Matthay M. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. PMID: 24395479.
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    258. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay M, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. PMID: 17804488.
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    259. Serikov VB, Popov B, Mikhailov VM, Gupta N, Matthay M. Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. Anat Rec (Hoboken). 2007 Sep; 290(9):1033-45. PMID: 17661377.
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    260. Matthay M, Taeusch W. Surfactant treatment of aspiration-induced lung injury in children. Pediatr Crit Care Med. 2007 Sep; 8(5):505-6. PMID: 17873790.
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    261. Ware LB, Matthay M, Parsons PE, Thompson BT, Januzzi JL, Eisner MD. Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med. 2007 Aug; 35(8):1821-8. PMID: 17667242; PMCID: PMC2764536.
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    265. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay M. Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest. 2007 Sep; 132(3):836-42. PMID: 17573490.
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    267. Brohi K, Cohen MJ, Ganter MT, Matthay M, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007 May; 245(5):812-8. PMID: 17457176; PMCID: PMC1877079.
    268. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay M. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L45-51. PMID: 17468134; PMCID: PMC4212816.
    269. Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay M. Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):186-92. PMID: 17431097; PMCID: PMC1976545.
    270. Fremont RD, Kallet RH, Matthay M, Ware LB. Postobstructive pulmonary edema: a case for hydrostatic mechanisms. Chest. 2007 Jun; 131(6):1742-6. PMID: 17413051; PMCID: PMC2783608.
    271. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay M. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007 May 15; 175(10):1006-13. PMID: 17363773; PMCID: PMC1899270.
    272. Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay M, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax. 2007 Jul; 62(7):608-16. PMID: 17356058; PMCID: PMC2117249.
    273. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay M. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L52-9. PMID: 17351061; PMCID: PMC2764531.
    274. Flori HR, Ware LB, Milet M, Matthay M. Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2007 Mar; 8(2):96-101. PMID: 17273112; PMCID: PMC3586228.
    275. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay M, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496; PMCID: PMC1855040.
    276. Calfee CS, Matthay M. Nonventilatory treatments for acute lung injury and ARDS. Chest. 2007 Mar; 131(3):913-920. PMID: 17356114; PMCID: PMC2789489.
    277. Frank JA, Parsons PE, Matthay M. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest. 2006 Dec; 130(6):1906-14. PMID: 17167015; PMCID: PMC2764530.
    278. Heresi GA, Arroliga AC, Wiedemann HP, Weidemann HP, Matthay M. Pulmonary artery catheter and fluid management in acute lung injury and the acute respiratory distress syndrome. Clin Chest Med. 2006 Dec; 27(4):627-35; abstract ix. PMID: 17085251.
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    279. Wang L, Bastarache JA, Wickersham N, Fang X, Matthay M, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):497-503. PMID: 17099142; PMCID: PMC1899324.
    280. Ning W, Dong Y, Sun J, Li C, Matthay M, Feghali-Bostwick CA, Choi AM. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):480-90. PMID: 17099140; PMCID: PMC1899323.
    281. Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay M, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med. 2006 Nov; 12(11):1286-93. PMID: 17086189; PMCID: PMC2768268.
    282. McClintock DE, Ware LB, Eisner MD, Wickersham N, Thompson BT, Matthay M. Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med. 2007 Feb 01; 175(3):256-62. PMID: 17082495; PMCID: PMC1899263.
    283. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay M, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2007 Mar; 36(3):377-86. PMID: 17079779; PMCID: PMC1899321.
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    285. Levitt JE, Matthay M. Treatment of acute lung injury: historical perspective and potential future therapies. Semin Respir Crit Care Med. 2006 Aug; 27(4):426-37. PMID: 16909376.
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    286. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay M. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Dec; 291(6):L1191-8. PMID: 16877636.
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    287. Sapru A, Wiemels JL, Witte JS, Ware LB, Matthay M. Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med. 2006 Sep; 32(9):1293-303. PMID: 16770611.
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    288. Gupta N, Matthay M. Sepsis and stretch: synergistic effects on alveolar epithelial cell death? Crit Care Med. 2006 Jun; 34(6):1846-7. PMID: 16714999.
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    289. Wiener-Kronish JP, Matthay M. Beta-2-agonist treatment as a potential therapy for acute inhalational lung injury. Crit Care Med. 2006 Jun; 34(6):1841-2. PMID: 16714996.
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    290. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay M. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475; PMCID: PMC1462945.
    291. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay M, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest. 2006 Jun; 116(6):1606-14. PMID: 16710477; PMCID: PMC1462943.
    292. McClintock DE, Starcher B, Eisner MD, Thompson BT, Hayden DL, Church GD, Matthay M. Higher urine desmosine levels are associated with mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L566-71. PMID: 16698854; PMCID: PMC2765125.
    293. Liu KD, Matthay M, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clin J Am Soc Nephrol. 2006 Jul; 1(4):869-73. PMID: 17699299.
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    294. Ganter MT, Ware LB, Howard M, Roux J, Gartland B, Matthay M, Fleshner M, Pittet JF. Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L354-61. PMID: 16679378; PMCID: PMC2765126.
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    296. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay M. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May; 34(5):523-6. PMID: 16618787.
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    297. Cepkova M, Matthay M. Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome. J Intensive Care Med. 2006 May-Jun; 21(3):119-43. PMID: 16672636; PMCID: PMC2765330.
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    299. Matthay M, Christman JW, Pitt BR, Schwiebert LM, Stevens T, Ware LB. Perspectives, translational research, and letters to the editor. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L621. PMID: 16531563.
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    300. Folkesson HG, Matthay M. Alveolar epithelial ion and fluid transport: recent progress. Am J Respir Cell Mol Biol. 2006 Jul; 35(1):10-9. PMID: 16514116; PMCID: PMC2658691.
    301. Curley MA, Arnold JH, Thompson JE, Fackler JC, Grant MJ, Fineman LD, Cvijanovich N, Barr FE, Molitor-Kirsch S, Steinhorn DM, Matthay M, Hibberd PL. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7. PMID: 16616620; PMCID: PMC1778462.
    302. Sakuma T, Gu X, Wang Z, Maeda S, Sugita M, Sagawa M, Osanai K, Toga H, Ware LB, Folkesson G, Matthay M. Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine. Crit Care Med. 2006 Mar; 34(3):676-81. PMID: 16505652; PMCID: PMC2765117.
    303. Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA, Matthay M. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Crit Care Med. 2006 May 01; 173(9):1008-15. PMID: 16456142; PMCID: PMC2662912.
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    305. Looney MR, Matthay M. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239. PMID: 17169139; PMCID: PMC1794467.
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    308. Su X, Robriquet L, Folkesson HG, Matthay M. Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L769-L776. PMID: 16284214.
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    309. Matthay M, Calfee CS. Therapeutic value of a lung protective ventilation strategy in acute lung injury. Chest. 2005 Nov; 128(5):3089-91. PMID: 16304246.
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    310. Matthay M, Zimmerman GA. Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):319-27. PMID: 16172252; PMCID: PMC2715340.
    311. Ware LB, Fang X, Wang Y, Babcock WD, Jones K, Matthay M. High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation. J Heart Lung Transplant. 2005 Oct; 24(10):1650-6. PMID: 16210143.
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    312. Fang X, Song Y, Hirsch J, Galietta LJ, Pedemonte N, Zemans RL, Dolganov G, Verkman AS, Matthay M. Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells. Am J Physiol Lung Cell Mol Physiol. 2006 Feb; 290(2):L242-9. PMID: 16143588.
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    313. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay M. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. PMID: 16081834.
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    314. Frank JA, Matthay M. Leukotrienes in acute lung injury: a potential therapeutic target? Am J Respir Crit Care Med. 2005 Aug 01; 172(3):261-2. PMID: 16040787; PMCID: PMC2718469.
    315. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay M, Arnold JH. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37. PMID: 16014597; PMCID: PMC1237036.
    316. Calfee CS, Matthay M. Recent advances in mechanical ventilation. Am J Med. 2005 Jun; 118(6):584-91. PMID: 15922687.
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    317. Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay M, Hollenberg MD, Marshall J, McCulloch CA, Abreu MT, Chow CW, Downey GP. Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol. 2005 Sep; 33(3):231-47. PMID: 15891109; PMCID: PMC2715314.
    318. Kallet RH, Daniel BM, Garcia O, Matthay M. Accuracy of physiologic dead space measurements in patients with acute respiratory distress syndrome using volumetric capnography: comparison with the metabolic monitor method. Respir Care. 2005 Apr; 50(4):462-7. PMID: 15807908.
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    319. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay M. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L104-10. PMID: 15781423.
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    320. Angus D, Ishizaka A, Matthay M, Lemaire F, Macnee W, Abraham E. Critical care in AJRCCM 2004. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):537-44. PMID: 15753483.
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    321. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay M, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005 May 13; 280(19):18579-89. PMID: 15755725.
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    322. Cheng IW, Eisner MD, Thompson BT, Ware LB, Matthay M. Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury. Crit Care Med. 2005 Jan; 33(1):63-70; discussion 239-40. PMID: 15644650.
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    323. Parsons PE, Eisner MD, Thompson BT, Matthay M, Ancukiewicz M, Bernard GR, Wheeler AP. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med. 2005 Jan; 33(1):1-6; discussion 230-2. PMID: 15644641.
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    324. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay M. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan; 33(1):181-8; discussion 254-5. PMID: 15644667.
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    325. McAuley DF, Matthay M. Is there a role for beta-adrenoceptor agonists in the management of acute lung injury and the acute respiratory distress syndrome? Treat Respir Med. 2005; 4(5):297-307. PMID: 16137187.
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    326. Matthay M, Robriquet L, Fang X. Alveolar epithelium: role in lung fluid balance and acute lung injury. Proc Am Thorac Soc. 2005; 2(3):206-13. PMID: 16222039.
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    327. Flori HR, Glidden DV, Rutherford GW, Matthay M. Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality. Am J Respir Crit Care Med. 2005 May 01; 171(9):995-1001. PMID: 15618461.
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    328. Matthay M, Ware LB. Can nicotine treat sepsis? Nat Med. 2004 Nov; 10(11):1161-2. PMID: 15516907.
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    329. Parsons PE, Matthay M, Ware LB, Eisner MD. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L426-31. PMID: 15516488.
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    330. Bandi VD, Munnur U, Matthay M. Acute lung injury and acute respiratory distress syndrome in pregnancy. Crit Care Clin. 2004 Oct; 20(4):577-607. PMID: 15388190.
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    331. Su X, Looney M, Robriquet L, Fang X, Matthay M. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. PMID: 15524406.
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    332. Kallet RH, Alonso JA, Pittet JF, Matthay M. Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome. Respir Care. 2004 Sep; 49(9):1008-14. PMID: 15329171.
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    333. Brower RG, Lanken PN, MacIntyre N, Matthay M, Morris A, Ancukiewicz M, Schoenfeld D, Thompson BT. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med. 2004 Jul 22; 351(4):327-36. PMID: 15269312.
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    334. Sue RD, Matthay M, Ware LB. Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema. Intensive Care Med. 2004 Oct; 30(10):1921-6. PMID: 15258730.
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    335. Looney MR, Gropper MA, Matthay M. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
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    336. Matthay M, Clements JA. Coagulation-dependent mechanisms and asthma. J Clin Invest. 2004 Jul; 114(1):20-3. PMID: 15232607; PMCID: PMC437975.
    337. McAuley DF, Frank JA, Fang X, Matthay M. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul; 32(7):1470-6. PMID: 15241090.
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    338. Hirsch J, Hansen KC, Burlingame AL, Matthay M. Proteomics: current techniques and potential applications to lung disease. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L1-23. PMID: 15187006.
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    339. Zemans RL, Matthay M. Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury. Crit Care. 2004 Dec; 8(6):469-77. PMID: 15566618; PMCID: PMC1065044.
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    341. Matthay M, Ware LB. Plasma protein C levels in patients with acute lung injury: prognostic significance. Crit Care Med. 2004 May; 32(5 Suppl):S229-32. PMID: 15118523.
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    342. Geiser T, Ishigaki M, van Leer C, Matthay M, Broaddus VC. H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L448-53. PMID: 15121637.
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    343. Hastings RH, Folkesson HG, Matthay M. Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L679-89. PMID: 15003932.
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    344. Zemans RL, Chatterjee K, Matthay M. Diagnostic utility of B-type natriuretic peptide in patients with acute dyspnea or pleural effusions. Am J Med. 2004 Mar 15; 116(6):424-6. PMID: 15006593.
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    345. Fang X, Song Y, Zemans R, Hirsch J, Matthay M. Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L104-10. PMID: 14990396.
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    346. Olman MA, White KE, Ware LB, Simmons WL, Benveniste EN, Zhu S, Pugin J, Matthay M. Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression. J Immunol. 2004 Feb 15; 172(4):2668-77. PMID: 14764742.
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    347. McClintock DE, Matthay M. Why does acute lung injury have no impact on mortality in patients with major trauma? Crit Care Med. 2004 Feb; 32(2):583-4. PMID: 14758183.
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    348. Bowler RP, Duda B, Chan ED, Enghild JJ, Ware LB, Matthay M, Duncan MW. Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1095-104. PMID: 14742308.
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    349. Krupa A, Kato H, Matthay M, Kurdowska AK. Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1105-13. PMID: 14729508.
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    350. Wang L, Zhu DM, Su X, Bai CX, Ware LB, Matthay M. Acute cardiopulmonary effects of a dual-endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp Lung Res. 2004 Jan-Feb; 30(1):31-42. PMID: 14967602.
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    351. Goodman RB, Pugin J, Lee JS, Matthay M. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 2003 Dec; 14(6):523-35. PMID: 14563354.
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    352. Pastor CM, Matthay M, Frossard JL. Pancreatitis-associated acute lung injury: new insights. Chest. 2003 Dec; 124(6):2341-51. PMID: 14665518.
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    353. Brower RG, Morris A, MacIntyre N, Matthay M, Hayden D, Thompson T, Clemmer T, Lanken PN, Schoenfeld D. Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med. 2003 Nov; 31(11):2592-7. PMID: 14605529.
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    354. Su X, Bai C, Hong Q, Zhu D, He L, Wu J, Ding F, Fang X, Matthay M. Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury. Intensive Care Med. 2003 Nov; 29(11):2034-42. PMID: 14557856.
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    355. Cheng IW, Matthay M. Acute lung injury and the acute respiratory distress syndrome. Crit Care Clin. 2003 Oct; 19(4):693-712. PMID: 14601715.
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    356. Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay M, Hashimoto S. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1088-94. PMID: 12959931.
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    357. Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay M, Day BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med. 2003 Sep; 31(9):2309-15. PMID: 14501961.
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    358. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay M, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem. 2003 Nov 07; 278(45):43939-50. PMID: 12930837.
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    359. Elia N, Tapponnier M, Matthay M, Hamacher J, Pache JC, Brundler MA, Totsch M, De Baetselier P, Fransen L, Fukuda N, Morel DR, Lucas R. Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha. Am J Respir Crit Care Med. 2003 Nov 01; 168(9):1043-50. PMID: 12842853.
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    360. Flori HR, Ware LB, Glidden D, Matthay M. Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation. Pediatr Crit Care Med. 2003 Jul; 4(3):315-21. PMID: 12831413.
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    361. Ware LB, Fang X, Matthay M. Protein C and thrombomodulin in human acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L514-21. PMID: 12754194.
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    362. Prabhakaran P, Ware LB, White KE, Cross MT, Matthay M, Olman MA. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L20-8. PMID: 12730079.
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    363. Folkesson HG, Matthay M. Therapeutic strategies to hasten the resolution of pulmonary edema. Crit Care Med. 2003 Apr; 31(4):1288-9. PMID: 12682513.
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    364. Matthay M, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2003 Apr 01; 167(7):1027-35. PMID: 12663342.
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    365. Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, Isabey D, Matthay M, Harf A, d'Ortho MP. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res. 2003 Feb 15; 283(2):215-29. PMID: 12581741.
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    366. Frank JA, Pittet JF, Lee H, Godzich M, Matthay M. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L791-8. PMID: 12562562.
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    367. Cheng IW, Ware LB, Greene KE, Nuckton TJ, Eisner MD, Matthay M. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit Care Med. 2003 Jan; 31(1):20-7. PMID: 12544988.
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    368. Matthay M. Alveolar fluid clearance in patients with ARDS: does it make a difference? Chest. 2002 Dec; 122(6 Suppl):340S-343S. PMID: 12475812.
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    369. Matthay M. Clinical measurement of pulmonary edema. Chest. 2002 Dec; 122(6):1877-9. PMID: 12475816.
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    370. Brower RG, Matthay M, Schoenfeld D. Meta-analysis of acute lung injury and acute respiratory distress syndrome trials. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1515-7. PMID: 12450936.
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    371. Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay M, Ware LB. Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol. 2002 Nov; 161(5):1783-96. PMID: 12414525; PMCID: PMC1850801.
    372. Pham I, Uchida T, Planes C, Ware LB, Kaner R, Matthay M, Clerici C. Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L1133-42. PMID: 12376368.
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    373. Ware LB, Fang X, Wang Y, Sakuma T, Hall TS, Matthay M. Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung. J Appl Physiol (1985). 2002 Nov; 93(5):1869-74. PMID: 12381777.
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    374. Ware LB, Matthay M. Measuring microvascular blood flow in sepsis--a continuing challenge. Lancet. 2002 Oct 19; 360(9341):1187-8. PMID: 12401242.
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    375. Frank JA, Matthay M. Science review: mechanisms of ventilator-induced injury. Crit Care. 2003 Jun; 7(3):233-41. PMID: 12793874; PMCID: PMC270664.
    376. Matthay M, Bhattacharya S, Gaver D, Ware LB, Lim LH, Syrkina O, Eyal F, Hubmayr R. Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L678-82. PMID: 12225942.
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    377. Matthay M, Clerici C, Saumon G. Invited review: Active fluid clearance from the distal air spaces of the lung. J Appl Physiol (1985). 2002 Oct; 93(4):1533-41. PMID: 12235056.
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    378. Jiang J, Song Y, Bai C, Koller BH, Matthay M, Verkman AS. Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. J Appl Physiol (1985). 2003 Jan; 94(1):343-52. PMID: 12391048.
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    379. Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet. 2002 Aug 24; 360(9333):619-20. PMID: 12241936.
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    380. Matthay M. The pulmonary epithelium is an important mediator of ventilator-induced lung injury. Crit Care Med. 2002 Aug; 30(8):1910-1. PMID: 12163818.
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    381. Fang X, Yang B, Matthay M, Verkman AS. Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney. J Physiol. 2002 Jul 01; 542(Pt 1):63-9. PMID: 12096051; PMCID: PMC2290384.
    382. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay M, Ware LB. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L163-9. PMID: 12060573.
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    383. Matthay M, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev. 2002 Jul; 82(3):569-600. PMID: 12087129.
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    384. Saint S, Savel RH, Matthay M. Enhancing the safety of critically ill patients by reducing urinary and central venous catheter-related infections. Am J Respir Crit Care Med. 2002 Jun 01; 165(11):1475-9. PMID: 12045119.
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    385. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay M. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Intensive Care Med. 2002 Jun; 28(6):705-11. PMID: 12107675.
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    386. Ware LB, Matthay M. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L924-40. PMID: 11943656.
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    387. Kurdowska AK, Geiser TK, Alden SM, Dziadek BR, Noble JM, Nuckton TJ, Matthay M. Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L1092-8. PMID: 11943675.
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    388. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay M. Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med. 2002 Apr 25; 346(17):1281-6. PMID: 11973365.
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    389. Matthay M, Uchida T, Fang X. Clinical Acute Lung Injury and Acute Respiratory Distress Syndrome. Curr Treat Options Cardiovasc Med. 2002 Apr; 4(2):139-149. PMID: 11858776.
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    390. Eisner MD, Thompson BT, Schoenfeld D, Anzueto A, Matthay M. Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002 Apr 01; 165(7):978-82. PMID: 11934725.
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    391. Olman MA, White KE, Ware LB, Cross MT, Zhu S, Matthay M. Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest. 2002 Mar; 121(3 Suppl):69S-70S. PMID: 11893691.
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    392. Laffon M, Jayr C, Barbry P, Wang Y, Folkesson HG, Pittet JF, Clerici C, Matthay M. Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats. Anesthesiology. 2002 Feb; 96(2):392-9. PMID: 11818773.
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    393. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay M. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med. 2002 Jan 15; 165(2):242-9. PMID: 11790662.
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    394. Looney MR, Matthay M. The Role of Protein C in Sepsis. Curr Infect Dis Rep. 2001 Oct; 3(5):413-418. PMID: 11559461.
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    395. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000 05 04; 342(18):1301-8. PMID: 10793162.
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