Harold Chapman, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-514-1210
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    Collapse Biography 
    Collapse Education and Training
    University of Alabama Schooll of Medicine, Birmingham, AlMD06/72Medicine
    University of Utah, Salt Lake City UT06/80Internal Medicine and Pulmonary Critical Care
    Collapse Awards and Honors
    National Institute of Health2001  - 2012Merit Award
    1998American Association of Physicians
    1987American Society for Clinical Investigation

    Collapse Overview 
    Collapse Overview
    The Chapman lab has had a longstanding interest and track record of innovation in the field of tissue remodeling, particularly as it relates to lung disease. For many years my work primarily focused on proteolytic enzymes. My group and I cloned and characterized several new members of the cathepsin family and elucidated their roles in bone, brain, lung, and immune disorders. I also pursued basic mechanisms by which proteases and adhesion receptors coordinate cell invasion and extracellular matrix remodeling and this has led to longstanding interest in integrin signaling. We were the first to recognize the physical and functional connections between integrins and the key cell surface protease, plasminogen activator. After moving from Harvard to UCSF 12 years ago I focused my lab on pulmonary fibrosis as a disorder of great unmet medical need and a logical extension of my prior work in matrix biology. I pioneered the in vivo investigation of the role of epithelial mesenchymal transition (EMT) in pulmonary fibrosis and uncovered mechanistic insight as to how integrins and hypoxia regulate epithelial cell plasticity. These studies have provided a roadmap for defining the role of EMT signaling in human fibrosis and lung cancer. More recently we have extended our studies of epithelial plasticity into the realm of lung stem/progenitor cells and are committed to defining the regenerative potential of the lung after injury.

    I have trained approximately twenty PhD and/or MD post-docs who now populate academic departments and pharmaceutical labs. As a physician scientist myself, I have particularly enjoyed the responsibility of motivating and training capable young physicians for careers in disease-oriented research. These now include Division and Department Chairs as well as several independent medicine faculty with successful NIH-funded research programs. My lab now is comprised of mainly PhD trainees and junior faculty and we are committed to understanding and targeting the emerging relationship between hypoxia, EMT, and tissue remodeling during fibrogenesis and cancer progression.

    Collapse Research 
    Collapse Research Activities and Funding
    Program to promote lung regeneration and block fibrosis
    NIH R35HL150767Feb 15, 2020 - Jan 31, 2027
    Role: Principal Investigator
    LOXL-2 dependent blockade of TGF Beta1 signaling and lung fibrosis
    NIH R01HL142265Feb 1, 2019 - Jan 31, 2020
    Role: Principal Investigator
    Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage
    NIH U01HL134766Sep 21, 2016 - May 31, 2023
    Role: Principal Investigator
    Epithelial Stem/Progenitor Cells in Repair of the Injured Lung
    NIH R01HL128484Jul 15, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH P01HL108794Aug 9, 2012 - Jul 31, 2018
    Role: Co-Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Identification, Isolation, and Reprogramming Alveolar Epithelial Progenitor Cells
    NIH R03HL096269Dec 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Urokinase Receptor Integrin Interactions in Lung Cancer
    NIH R01CA125564Jul 1, 2007 - May 31, 2013
    Role: Principal Investigator
    Role of Elastolytic Cathepsins in Emphysema
    NIH R37HL067204Jun 1, 2001 - May 31, 2012
    Role: Principal Investigator
    CATHEPSIN S AND ALZHEIMERS DISEASE
    NIH R01AG012959Aug 20, 1995 - Jul 31, 1998
    Role: Principal Investigator
    Cysteine Proteases in MHC Class II Antigen Presentation
    NIH R01HL048261Jan 1, 1993 - Dec 31, 2007
    Role: Principal Investigator
    Epithelial Mesenchymal Transition in Pulmonary Fibrosis
    NIH R01HL044712Jan 1, 1991 - Dec 31, 2014
    Role: Principal Investigator
    ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA
    NIH R01HL036563Dec 1, 1985 - Jun 30, 1988
    Role: Principal Investigator
    INTERACTION OF HUMAN ALVEOLAR MACROPHAGES WIH FIBRIN
    NIH R01HL036548Sep 30, 1985 - Mar 31, 1989
    Role: Principal Investigator
    ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA
    NIH R01HL033945Jul 1, 1985 - Aug 31, 1985
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity. Cell Rep. 2021 Apr 20; 35(3):109009. Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, Guo HF, Yu J, Rodriguez BL, Firestone JJA, Mino B, Creighton CJ, Solis LM, Villalobos P, Raso MG, Sazer DW, Gibbons DL, Russell WK, Longmore GD, Wistuba II, Wang J, Chapman HA, Miller JS, Zong C, Kurie JM. PMID: 33882319.
      View in: PubMed   Mentions:    Fields:    
    2. Blocking LOXL2 and TGFß1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis. Thorax. 2021 Jul; 76(7):729-732. Wei Y, Dong W, Jackson J, Ho TC, Le Saux CJ, Brumwell A, Li X, Klesney-Tait J, Cohen ML, Wolters PJ, Chapman HA. PMID: 33472968.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Nat Commun. 2020 09 09; 11(1):4520. Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL. PMID: 32908154.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    4. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Nat Commun. 2020 07 16; 11(1):3559. Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB. PMID: 32678092.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    5. Reversal of TGFß1-Driven Profibrotic State in Patients with Pulmonary Fibrosis. N Engl J Med. 2020 03 12; 382(11):1068-1070. Chapman HA, Wei Y, Montas G, Leong D, Golden JA, Trinh BN, Wolters PJ, Le Saux CJ, Jones KD, Hills NK, Foster E, Oldham JM, Linderholm AL, Kotak P, Decaris M, Turner S, Song JW. PMID: 32160670.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    6. VEGF Drives the Car toward Better Gas Exchange. Dev Cell. 2020 03 09; 52(5):546-547. Kathiriya JJ, Chapman HA. PMID: 32155436.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration. Cell Stem Cell. 2020 03 05; 26(3):346-358.e4. Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA. PMID: 31978363.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    8. Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. JCI Insight. 2019 12 19; 4(24). Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C. PMID: 31687975.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    9. B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes. Front Immunol. 2019; 10:1732. Egia-Mendikute L, Arpa B, Rosell-Mases E, Corral-Pujol M, Carrascal J, Carrillo J, Mora C, Chapman H, Panosa A, Vives-Pi M, Stratmann T, Serreze D, Verdaguer J. PMID: 31428087.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Yap/Taz regulate alveolar regeneration and resolution of lung inflammation. J Clin Invest. 2019 04 15; 129(5):2107-2122. LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y. PMID: 30985294.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    11. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019; 14(1):e0209824. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. PMID: 30625178.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    12. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited. Am J Respir Cell Mol Biol. 2018 08; 59(2):137-138. Le Saux CJ, Chapman HA. PMID: 29698615.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. PMID: 29999500.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. TGF-ß1 Signaling and Tissue Fibrosis. Cold Spring Harb Perspect Biol. 2018 04 02; 10(4). Kim KK, Sheppard D, Chapman HA. PMID: 28432134.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    15. Extracellular matrix in lung development, homeostasis and disease. Matrix Biol. 2018 11; 73:77-104. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. PMID: 29524630.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    16. Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. PMID: 28872461.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    17. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. PMID: 28737769.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    18. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017 Aug; 187(8):1772-1786. McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. PMID: 28618253.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Failure of Alveolar Type 2 Cell Maintenance Links Neonatal Distress with Adult Lung Disease. Am J Respir Cell Mol Biol. 2017 04; 56(4):415-416. Vaughan AE, Chapman HA. PMID: 28362148.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 10; 55(4):613-615. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. PMID: 27689795.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    21. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. PMID: 25533958.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    22. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. PMID: 25526531.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    23. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 07; 15(2):123-38. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. PMID: 25105578.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansAnimalsCells
    24. Soluble urokinase-type plasminogen activator receptor in FSGS: stirred but not shaken. J Am Soc Nephrol. 2014 Aug; 25(8):1611-3. Reiser J, Chapman H. PMID: 24790180.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. J Biol Chem. 2014 May 02; 289(18):12791-804. Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA. PMID: 24644284.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. PMID: 24160862.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    27. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline. Am J Respir Cell Mol Biol. 2014 Jan; 50(1):51-60. Xi Y, Tan K, Brumwell AN, Chen SC, Kim YH, Kim TJ, Wei Y, Chapman HA. PMID: 23944988.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013 Oct 09; 5(206):206ra139. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. PMID: 24107778.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    29. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013 Nov; 183(5):1559-1570. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. PMID: 24012677.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    30. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. PMID: 23713908.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    31. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. PMID: 23607856.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    32. Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Apr 01; 22(7):1417-23. Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M. PMID: 23297359.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    33. Regenerative activity of the lung after epithelial injury. Biochim Biophys Acta. 2013 Jul; 1832(7):922-30. Vaughan AE, Chapman HA. PMID: 23219956.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    34. Epithelial responses to lung injury: role of the extracellular matrix. Proc Am Thorac Soc. 2012 Jul; 9(3):89-95. Chapman HA. PMID: 22802280.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    35. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2012 Mar; 2(3):270-87. Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM. PMID: 22585997.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    36. Axin pathway activity regulates in vivo pY654-ß-catenin accumulation and pulmonary fibrosis. J Biol Chem. 2012 Feb 10; 287(7):5164-72. Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA. PMID: 22203675.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    37. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul; 121(7):2855-62. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. PMID: 21701069.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    38. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. PMID: 21653526.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    39. Toward lung regeneration. N Engl J Med. 2011 May 12; 364(19):1867-8. Chapman HA. PMID: 21561353.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. . 2011 Jul; 301(1):L71-8. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ. PMID: 21498628.
      View in: PubMed   Mentions:
    41. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol. 2011; 73:413-35. Chapman HA. PMID: 21054168.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    42. Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins. . 2009 Jul; 297(1):L97-108. Zhu S, Gladson CL, White KE, Ding Q, Stewart J, Jin TH, Chapman HA, Olman MA. PMID: 19411312.
      View in: PubMed   Mentions:
    43. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development. 2009 Mar; 136(5):843-53. Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA. PMID: 19176588.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    44. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol. 2009 Jan 26; 184(2):309-22. Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA. PMID: 19171760.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    45. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. PMID: 19104148.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansAnimalsCells
    46. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins. J Cell Sci. 2008 Nov 15; 121(Pt 22):3747-56. Tang CH, Hill ML, Brumwell AN, Chapman HA, Wei Y. PMID: 18940913.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    47. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature. 2008 Dec 04; 456(7222):658-62. Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. PMID: 18820679.
      View in: PubMed   Mentions: 263     Fields:    Translation:AnimalsCells
    48. Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007 Jul; 37(1):1-2. Kim KK, Chapman HA. PMID: 17575081.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    49. Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem. 2007 Feb 09; 282(6):3929-39. Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA. PMID: 17145753.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    50. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol. 2006 Nov 01; 177(9):5779-84. Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP. PMID: 17056501.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    51. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13180-5. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. PMID: 16924102.
      View in: PubMed   Mentions: 495     Fields:    Translation:HumansAnimalsCells
    52. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem. 2006 Aug; 387(8):1143-6. Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ. PMID: 16895486.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    53. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. PMID: 16921128.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    54. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol. 2006 Mar; 26(6):2309-16. Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA. PMID: 16508006.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    55. Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem. 2006 May 12; 281(19):13021-13029. Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS. PMID: 16510444.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    56. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem. 2006 Mar 03; 281(9):6020-9. Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP. PMID: 16365041.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    57. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64. Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. PMID: 16358219.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    58. Endosomal proteases in antigen presentation. Curr Opin Immunol. 2006 Feb; 18(1):78-84. Chapman HA. PMID: 16338127.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    59. Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease. Immunology. 2005 Dec; 116(4):532-40. Kala M, Chen CR, McLachlan SM, Rapoport B, Aliesky H, Chapman HA. PMID: 16313367.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    60. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):355-62. Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA. PMID: 16081882.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    61. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol. 2005 Jun 15; 174(12):8106-15. Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. PMID: 15944319.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    62. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. J Immunol. 2005 Feb 01; 174(3):1729-37. Yang H, Kala M, Scott BG, Goluszko E, Chapman HA, Christadoss P. PMID: 15661938.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    63. Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. J Cell Biol. 2005 Jan 31; 168(3):501-11. Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA. PMID: 15684035.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    64. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005 Feb 18; 96(3):368-75. Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. PMID: 15653570.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    65. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):628-32. Aslanian AM, Chapman HA, Charo IF. PMID: 15591216.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    66. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301. DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST, Silverman EK. PMID: 15347563.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    67. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. PMID: 15197138.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    68. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56. Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. PMID: 15175276.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    69. Cathepsins as transcriptional activators? Dev Cell. 2004 May; 6(5):610-1. Chapman HA. PMID: 15130484.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    70. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol. 2004 Apr; 164(4):1131-9. DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M. PMID: 15039201.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    71. Disorders of lung matrix remodeling. J Clin Invest. 2004 Jan; 113(2):148-57. Chapman HA. PMID: 14722604.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    72. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. J Cell Biol. 2003 Oct 13; 163(1):177-88. Zhang F, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, Chapman HA. PMID: 14557254.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    73. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem. 2003 Oct-Nov; 384(10-11):1527-31. Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G. PMID: 14669996.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    74. Matrilysin-dependent elastolysis by human macrophages. J Exp Med. 2003 Sep 15; 198(6):925-35. Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ. PMID: 12963695.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    75. Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease. Hum Mol Genet. 2003 May 15; 12(10):1199-210. Palmer LJ, Celedón JC, Chapman HA, Speizer FE, Weiss ST, Silverman EK. PMID: 12719384.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    76. Urokinase receptor and integrin interactions. Curr Pharm Des. 2003; 9(19):1565-74. Kugler MC, Wei Y, Chapman HA. PMID: 12871068.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    77. The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease. J Immunol. 2002 Dec 15; 169(12):6720-32. Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS. PMID: 12471103.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    78. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2002 Jul 15; 166(2):236-46. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. PMID: 12119236.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    79. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen. J Immunol. 2002 Jun 01; 168(11):5551-7. Wu ZQ, Shen Y, Khan AQ, Chu CL, Riese R, Chapman HA, Kanagawa O, Snapper CM. PMID: 12023350.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    80. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. PMID: 11985866.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    81. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet. 2002 May; 70(5):1229-39. Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. PMID: 11914989.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    82. Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet. 2002 Mar 15; 11(6):623-32. Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. PMID: 11912177.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    83. Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts. Chest. 2002 Mar; 121(3 Suppl):34S-35S. Zhu S, Gladson CL, Stewart J, White KE, Chapman HA, Olman MA. PMID: 11893675.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    84. Random peptide bacteriophage display as a probe for urokinase receptor ligands. Biol Chem. 2002 Jan; 383(1):149-58. Fong S, Doyle MV, Goodson RJ, Drummond RJ, Stratton JR, McGuire L, Doyle LV, Chapman HA, Rosenberg S. PMID: 11928809.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
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