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Harold Chapman, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-514-1210
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    Collapse Biography 
    Collapse Awards and Honors
    National Institute of Health2001  - 2012Merit Award
    1998American Association of Physicians
    1987American Society for Clinical Investigation

    Collapse Overview 
    Collapse Overview
    The Chapman lab has had a longstanding interest and track record of innovation in the field of tissue remodeling, particularly as it relates to lung disease. For many years my work primarily focused on proteolytic enzymes. My group and I cloned and characterized several new members of the cathepsin family and elucidated their roles in bone, brain, lung, and immune disorders. I also pursued basic mechanisms by which proteases and adhesion receptors coordinate cell invasion and extracellular matrix remodeling and this has led to longstanding interest in integrin signaling. We were the first to recognize the physical and functional connections between integrins and the key cell surface protease, plasminogen activator. After moving from Harvard to UCSF 12 years ago I focused my lab on pulmonary fibrosis as a disorder of great unmet medical need and a logical extension of my prior work in matrix biology. I pioneered the in vivo investigation of the role of epithelial mesenchymal transition (EMT) in pulmonary fibrosis and uncovered mechanistic insight as to how integrins and hypoxia regulate epithelial cell plasticity. These studies have provided a roadmap for defining the role of EMT signaling in human fibrosis and lung cancer. More recently we have extended our studies of epithelial plasticity into the realm of lung stem/progenitor cells and are committed to defining the regenerative potential of the lung after injury.

    I have trained approximately twenty PhD and/or MD post-docs who now populate academic departments and pharmaceutical labs. As a physician scientist myself, I have particularly enjoyed the responsibility of motivating and training capable young physicians for careers in disease-oriented research. These now include Division and Department Chairs as well as several independent medicine faculty with successful NIH-funded research programs. My lab now is comprised of mainly PhD trainees and junior faculty and we are committed to understanding and targeting the emerging relationship between hypoxia, EMT, and tissue remodeling during fibrogenesis and cancer progression.

    Collapse Research 
    Collapse Research Activities and Funding
    Program to promote lung regeneration and block fibrosis
    NIH/NHLBI R35HL150767Feb 15, 2020 - Jan 31, 2027
    Role: Principal Investigator
    LOXL-2 dependent blockade of TGF Beta1 signaling and lung fibrosis
    NIH/NHLBI R01HL142265Feb 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Epithelial stem/progenitor cells as repair agents in diffuse alveolar damage
    NIH/NHLBI U01HL134766Sep 21, 2016 - May 31, 2023
    Role: Principal Investigator
    Epithelial Stem/Progenitor Cells in Repair of the Injured Lung
    NIH/NHLBI R01HL128484Jul 15, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Targeting epithelial cells to treat pulmonary fibrosis
    NIH/NHLBI P01HL108794Aug 9, 2012 - Jul 31, 2017
    Role: Co-Investigator
    Epithelial Progenitor Cells in Lung Repair and Regeneration
    NIH/NHLBI U01HL111054Jan 1, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Identification, Isolation, and Reprogramming Alveolar Epithelial Progenitor Cells
    NIH/NHLBI R03HL096269Dec 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Urokinase Receptor Integrin Interactions in Lung Cancer
    NIH/NCI R01CA125564Jul 1, 2007 - May 31, 2013
    Role: Principal Investigator
    Role of Elastolytic Cathepsins in Emphysema
    NIH/NHLBI R37HL067204Jun 1, 2001 - May 31, 2012
    Role: Principal Investigator
    CATHEPSIN S AND ALZHEIMERS DISEASE
    NIH/NIA R01AG012959Aug 20, 1995 - Jul 31, 1998
    Role: Principal Investigator
    Cysteine Proteases in MHC Class II Antigen Presentation
    NIH/NHLBI R01HL048261Jan 1, 1993 - Dec 31, 2007
    Role: Principal Investigator
    Epithelial Mesenchymal Transition in Pulmonary Fibrosis
    NIH/NHLBI R01HL044712Jan 1, 1991 - Dec 31, 2014
    Role: Principal Investigator
    ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA
    NIH/NHLBI R01HL036563Dec 1, 1985 - Jun 30, 1988
    Role: Principal Investigator
    INTERACTION OF HUMAN ALVEOLAR MACROPHAGES WIH FIBRIN
    NIH/NHLBI R01HL036548Sep 30, 1985 - Sep 29, 1988
    Role: Principal Investigator
    ROLE OF HUMAN ALVEOLAR MACROPHAGES IN EMPHYSEMA
    NIH/NHLBI R01HL033945Jul 1, 1985 - Aug 31, 1985
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. Nat Commun. 2020 09 09; 11(1):4520. Peng DH, Rodriguez BL, Diao L, Chen L, Wang J, Byers LA, Wei Y, Chapman HA, Yamauchi M, Behrens C, Raso G, Soto LMS, Cuentes ERP, Wistuba II, Kurie JM, Gibbons DL. PMID: 32908154.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Nat Commun. 2020 07 16; 11(1):3559. Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB. PMID: 32678092.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Reversal of TGFß1-Driven Profibrotic State in Patients with Pulmonary Fibrosis. N Engl J Med. 2020 03 12; 382(11):1068-1070. Chapman HA, Wei Y, Montas G, Leong D, Golden JA, Trinh BN, Wolters PJ, Le Saux CJ, Jones KD, Hills NK, Foster E, Oldham JM, Linderholm AL, Kotak P, Decaris M, Turner S, Song JW. PMID: 32160670.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. VEGF Drives the Car toward Better Gas Exchange. Dev Cell. 2020 Mar 09; 52(5):546-547. Kathiriya JJ, Chapman HA. PMID: 32155436.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration. Cell Stem Cell. 2020 03 05; 26(3):346-358.e4. Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA. PMID: 31978363.
      View in: PubMed   Mentions: 4     Fields:    
    6. Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis. JCI Insight. 2019 12 19; 4(24). Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, Alimirah F, Castellanos CA, Ruan R, Wei Y, Chapman HA, Ramanathan A, Campisi J, Jourdan Le Saux C. PMID: 31687975.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes. Front Immunol. 2019; 10:1732. Egia-Mendikute L, Arpa B, Rosell-Mases E, Corral-Pujol M, Carrascal J, Carrillo J, Mora C, Chapman H, Panosa A, Vives-Pi M, Stratmann T, Serreze D, Verdaguer J. PMID: 31428087.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Yap/Taz regulate alveolar regeneration and resolution of lung inflammation. J Clin Invest. 2019 04 15; 129(5):2107-2122. LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y. PMID: 30985294.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PLoS One. 2019; 14(1):e0209824. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. PMID: 30625178.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited. Am J Respir Cell Mol Biol. 2018 08; 59(2):137-138. Le Saux CJ, Chapman HA. PMID: 29698615.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. PMID: 29999500.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. TGF-ß1 Signaling and Tissue Fibrosis. Cold Spring Harb Perspect Biol. 2018 04 02; 10(4). Kim KK, Sheppard D, Chapman HA. PMID: 28432134.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    13. Extracellular matrix in lung development, homeostasis and disease. Matrix Biol. 2018 11; 73:77-104. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. PMID: 29524630.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    14. Fibroblast-specific inhibition of TGF-ß1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017 Oct 02; 127(10):3675-3688. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. PMID: 28872461.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. PMID: 28737769.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    16. Hypoxia-Inducible Factor 1a Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017 Aug; 187(8):1772-1786. McClendon J, Jansing NL, Redente EF, Gandjeva A, Ito Y, Colgan SP, Ahmad A, Riches DWH, Chapman HA, Mason RJ, Tuder RM, Zemans RL. PMID: 28618253.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Failure of Alveolar Type 2 Cell Maintenance Links Neonatal Distress with Adult Lung Disease. Am J Respir Cell Mol Biol. 2017 04; 56(4):415-416. Vaughan AE, Chapman HA. PMID: 28362148.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 10; 55(4):613-615. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. PMID: 27689795.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. PMID: 25533958.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    20. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Mol Cell. 2014 Dec 18; 56(6):723-37. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. PMID: 25526531.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 07; 15(2):123-38. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. PMID: 25105578.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansAnimalsCells
    22. Soluble urokinase-type plasminogen activator receptor in FSGS: stirred but not shaken. J Am Soc Nephrol. 2014 Aug; 25(8):1611-3. Reiser J, Chapman H. PMID: 24790180.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. J Biol Chem. 2014 May 02; 289(18):12791-804. Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA. PMID: 24644284.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    24. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. PMID: 24160862.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    25. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline. Am J Respir Cell Mol Biol. 2014 Jan; 50(1):51-60. Xi Y, Tan K, Brumwell AN, Chen SC, Kim YH, Kim TJ, Wei Y, Chapman HA. PMID: 23944988.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    26. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Sci Transl Med. 2013 Oct 09; 5(206):206ra139. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. PMID: 24107778.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    27. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Am J Pathol. 2013 Nov; 183(5):1559-1570. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. PMID: 24012677.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    28. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med. 2013 Aug 01; 188(3):370-5. Matthay MA, Anversa P, Bhattacharya J, Burnett BK, Chapman HA, Hare JM, Hei DJ, Hoffman AM, Kourembanas S, McKenna DH, Ortiz LA, Ott HC, Tente W, Thébaud B, Trapnell BC, Weiss DJ, Yuan JX, Blaisdell CJ. PMID: 23713908.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    29. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. PMID: 23607856.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    30. Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis. Hum Mol Genet. 2013 Apr 01; 22(7):1417-23. Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M. PMID: 23297359.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    31. Identification of pY654-ß-catenin as a critical co-factor in hypoxia-inducible factor-1a signaling and tumor responses to hypoxia. Oncogene. 2013 Oct 17; 32(42):5048-57. Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA. PMID: 23246962.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. Regenerative activity of the lung after epithelial injury. Biochim Biophys Acta. 2013 Jul; 1832(7):922-30. Vaughan AE, Chapman HA. PMID: 23219956.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    33. Epithelial responses to lung injury: role of the extracellular matrix. Proc Am Thorac Soc. 2012 Jul; 9(3):89-95. Chapman HA. PMID: 22802280.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    34. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2012 Mar; 2(3):270-87. Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, Tabruyn SP, You WK, Chapman HA, Christensen JG, Aftab DT, McDonald DM. PMID: 22585997.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    35. Axin pathway activity regulates in vivo pY654-ß-catenin accumulation and pulmonary fibrosis. J Biol Chem. 2012 Feb 10; 287(7):5164-72. Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA. PMID: 22203675.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    36. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul; 121(7):2855-62. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. PMID: 21701069.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    37. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. PMID: 21653526.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. Toward lung regeneration. N Engl J Med. 2011 May 12; 364(19):1867-8. Chapman HA. PMID: 21561353.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis. . 2011 Jul; 301(1):L71-8. Marmai C, Sutherland RE, Kim KK, Dolganov GM, Fang X, Kim SS, Jiang S, Golden JA, Hoopes CW, Matthay MA, Chapman HA, Wolters PJ. PMID: 21498628.
      View in: PubMed   Mentions:
    40. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol. 2011; 73:413-35. Chapman HA. PMID: 21054168.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    41. Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins. . 2009 Jul; 297(1):L97-108. Zhu S, Gladson CL, White KE, Ding Q, Stewart J, Jin TH, Chapman HA, Olman MA. PMID: 19411312.
      View in: PubMed   Mentions:
    42. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development. 2009 Mar; 136(5):843-53. Liu Y, Chattopadhyay N, Qin S, Szekeres C, Vasylyeva T, Mahoney ZX, Taglienti M, Bates CM, Chapman HA, Miner JH, Kreidberg JA. PMID: 19176588.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    43. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol. 2009 Jan 26; 184(2):309-22. Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, Chapman HA. PMID: 19171760.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    44. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. PMID: 19104148.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    45. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins. J Cell Sci. 2008 Nov 15; 121(Pt 22):3747-56. Tang CH, Hill ML, Brumwell AN, Chapman HA, Wei Y. PMID: 18940913.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    46. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature. 2008 Dec 04; 456(7222):658-62. Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. PMID: 18820679.
      View in: PubMed   Mentions: 224     Fields:    Translation:AnimalsCells
    47. Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007 Jul; 37(1):1-2. Kim KK, Chapman HA. PMID: 17575081.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    48. Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem. 2007 Feb 09; 282(6):3929-39. Wei Y, Tang CH, Kim Y, Robillard L, Zhang F, Kugler MC, Chapman HA. PMID: 17145753.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    49. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol. 2006 Nov 01; 177(9):5779-84. Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP. PMID: 17056501.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    50. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13180-5. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. PMID: 16924102.
      View in: PubMed   Mentions: 457     Fields:    Translation:HumansAnimalsCells
    51. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem. 2006 Aug; 387(8):1143-6. Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ. PMID: 16895486.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    52. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. PMID: 16921128.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    53. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol. 2006 Mar; 26(6):2309-16. Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA. PMID: 16508006.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    54. Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem. 2006 May 12; 281(19):13021-9. Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS. PMID: 16510444.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    55. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem. 2006 Mar 03; 281(9):6020-9. Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP. PMID: 16365041.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    56. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64. Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. PMID: 16358219.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    57. Endosomal proteases in antigen presentation. Curr Opin Immunol. 2006 Feb; 18(1):78-84. Chapman HA. PMID: 16338127.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    58. Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease. Immunology. 2005 Dec; 116(4):532-40. Kala M, Chen CR, McLachlan SM, Rapoport B, Aliesky H, Chapman HA. PMID: 16313367.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    59. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):355-62. Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA. PMID: 16081882.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    60. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol. 2005 Jun 15; 174(12):8106-15. Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. PMID: 15944319.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    61. Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis. J Immunol. 2005 Feb 01; 174(3):1729-37. Yang H, Kala M, Scott BG, Goluszko E, Chapman HA, Christadoss P. PMID: 15661938.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    62. Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. J Cell Biol. 2005 Jan 31; 168(3):501-11. Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA. PMID: 15684035.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    63. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005 Feb 18; 96(3):368-75. Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. PMID: 15653570.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    64. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):628-32. Aslanian AM, Chapman HA, Charo IF. PMID: 15591216.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    65. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301. DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST, Silverman EK. PMID: 15347563.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    66. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. PMID: 15197138.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    67. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56. Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. PMID: 15175276.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    68. Cathepsins as transcriptional activators? Dev Cell. 2004 May; 6(5):610-1. Chapman HA. PMID: 15130484.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    69. Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. Thorax. 2004 May; 59(5):396-400. DeMeo DL, Carey VJ, Chapman HA, Reilly JJ, Ginns LC, Speizer FE, Weiss ST, Silverman EK. PMID: 15115866.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    70. Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol. 2004 Apr; 164(4):1131-9. DeClerck YA, Mercurio AM, Stack MS, Chapman HA, Zutter MM, Muschel RJ, Raz A, Matrisian LM, Sloane BF, Noel A, Hendrix MJ, Coussens L, Padarathsingh M. PMID: 15039201.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    71. Disorders of lung matrix remodeling. J Clin Invest. 2004 Jan; 113(2):148-57. Chapman HA. PMID: 14722604.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    72. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. J Cell Biol. 2003 Oct 13; 163(1):177-88. Zhang F, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, Chapman HA. PMID: 14557254.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    73. Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem. 2003 Oct-Nov; 384(10-11):1527-31. Henningsson F, Wolters P, Chapman HA, Caughey GH, Pejler G. PMID: 14669996.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    74. Matrilysin-dependent elastolysis by human macrophages. J Exp Med. 2003 Sep 15; 198(6):925-35. Filippov S, Caras I, Murray R, Matrisian LM, Chapman HA, Shapiro S, Weiss SJ. PMID: 12963695.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    75. Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease. Hum Mol Genet. 2003 May 15; 12(10):1199-210. Palmer LJ, Celedón JC, Chapman HA, Speizer FE, Weiss ST, Silverman EK. PMID: 12719384.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    76. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 2003 Mar 21; 92(5):493-500. Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P. PMID: 12600886.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    77. Urokinase receptor and integrin interactions. Curr Pharm Des. 2003; 9(19):1565-74. Kugler MC, Wei Y, Chapman HA. PMID: 12871068.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    78. The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease. J Immunol. 2002 Dec 15; 169(12):6720-32. Stüve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS. PMID: 12471103.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    79. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2002 Jul 15; 166(2):236-46. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. PMID: 12119236.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    80. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen. J Immunol. 2002 Jun 01; 168(11):5551-7. Wu ZQ, Shen Y, Khan AQ, Chu CL, Riese R, Chapman HA, Kanagawa O, Snapper CM. PMID: 12023350.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    81. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. PMID: 11985866.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    82. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet. 2002 May; 70(5):1229-39. Silverman EK, Palmer LJ, Mosley JD, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. PMID: 11914989.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    83. Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet. 2002 Mar 15; 11(6):623-32. Silverman EK, Mosley JD, Palmer LJ, Barth M, Senter JM, Brown A, Drazen JM, Kwiatkowski DJ, Chapman HA, Campbell EJ, Province MA, Rao DC, Reilly JJ, Ginns LC, Speizer FE, Weiss ST. PMID: 11912177.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    84. Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human lung fibroblasts. Chest. 2002 Mar; 121(3 Suppl):34S-35S. Zhu S, Gladson CL, Stewart J, White KE, Chapman HA, Olman MA. PMID: 11893675.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    85. Random peptide bacteriophage display as a probe for urokinase receptor ligands. Biol Chem. 2002 Jan; 383(1):149-58. Fong S, Doyle MV, Goodson RJ, Drummond RJ, Stratton JR, McGuire L, Doyle LV, Chapman HA, Rosenberg S. PMID: 11928809.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    86. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity. 2001 Dec; 15(6):909-19. Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. PMID: 11754813.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    87. Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1. Mol Biol Cell. 2001 Oct; 12(10):2975-86. Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA. PMID: 11598185.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    88. Protease crosstalk with integrins: the urokinase receptor paradigm. Thromb Haemost. 2001 Jul; 86(1):124-9. Chapman HA, Wei Y. PMID: 11486997.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    89. Expression of cathepsins B and S in the progression of prostate carcinoma. Int J Cancer. 2001 Jan 20; 95(1):51-5. Fernández PL, Farré X, Nadal A, Fernández E, Peiró N, Sloane BF, Shi GP, Chapman HA, Campo E, Cardesa A. PMID: 11241311.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    90. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med. 2000 Dec 04; 192(11):1587-600. Wang Z, Zheng T, Zhu Z, Homer RJ, Riese RJ, Chapman HA, Shapiro SD, Elias JA. PMID: 11104801.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimals
    91. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 Dec; 162(6):2152-8. Silverman EK, Weiss ST, Drazen JM, Chapman HA, Carey V, Campbell EJ, Denish P, Silverman RA, Celedon JC, Reilly JJ, Ginns LC, Speizer FE. PMID: 11112130.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    92. Importance of lysosomal cysteine proteases in lung disease. Respir Res. 2000; 1(3):170-7. Wolters PJ, Chapman HA. PMID: 11667982.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    93. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest. 2000 Nov; 106(9):1081-93. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ, Chapman HA, Shapiro SD, Elias JA. PMID: 11067861.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    94. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. Biochemistry. 2000 Jun 20; 39(24):7081-91. Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA. PMID: 10852705.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    95. Protease injury in the development of COPD: Thomas A. Neff Lecture. Chest. 2000 May; 117(5 Suppl 1):295S-9S. Chapman HA, Shi GP. PMID: 10843961.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    96. Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function. J Biol Chem. 2000 Apr 07; 275(14):10228-34. Simon DI, Wei Y, Zhang L, Rao NK, Xu H, Chen Z, Liu Q, Rosenberg S, Chapman HA. PMID: 10744708.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    97. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. J Exp Med. 2000 Apr 03; 191(7):1177-86. Shi GP, Bryant RA, Riese R, Verhelst S, Driessen C, Li Z, Bromme D, Ploegh HL, Chapman HA. PMID: 10748235.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    98. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM. EMBO J. 2000 Mar 01; 19(5):882-91. Villadangos JA, Driessen C, Shi GP, Chapman HA, Ploegh HL. PMID: 10698930.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    99. Nonproteolytic role for the urokinase receptor in cellular migration in vivo. Am J Respir Cell Mol Biol. 2000 Mar; 22(3):316-22. Waltz DA, Fujita RM, Yang X, Natkin L, Zhuo S, Gerard CJ, Rosenberg S, Chapman HA. PMID: 10696068.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    100. Cathepsins and compartmentalization in antigen presentation. Curr Opin Immunol. 2000 Feb; 12(1):107-13. Riese RJ, Chapman HA. PMID: 10679409.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    101. Proteases involved in MHC class II antigen presentation. Immunol Rev. 1999 Dec; 172:109-20. Villadangos JA, Bryant RA, Deussing J, Driessen C, Lennon-Duménil AM, Riese RJ, Roth W, Saftig P, Shi GP, Chapman HA, Peters C, Ploegh HL. PMID: 10631941.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    102. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J Cell Biol. 1999 Nov 15; 147(4):775-90. Driessen C, Bryant RA, Lennon-Duménil AM, Villadangos JA, Bryant PW, Shi GP, Chapman HA, Ploegh HL. PMID: 10562280.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    103. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest. 1999 Nov; 104(9):1191-7. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA. PMID: 10545518.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    104. Role of urokinase receptor and caveolin in regulation of integrin signaling. Thromb Haemost. 1999 Aug; 82(2):291-7. Chapman HA, Wei Y, Simon DI, Waltz DA. PMID: 10605716.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    105. A Fas pathway to pulmonary fibrosis. J Clin Invest. 1999 Jul; 104(1):1-2. Chapman HA. PMID: 10393691.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    106. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol. 1999 Mar 22; 144(6):1285-94. Wei Y, Yang X, Liu Q, Wilkins JA, Chapman HA. PMID: 10087270.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    107. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity. 1999 Feb; 10(2):197-206. Shi GP, Villadangos JA, Dranoff G, Small C, Gu L, Haley KJ, Riese R, Ploegh HL, Chapman HA. PMID: 10072072.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCellsPHPublic Health
    108. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. 1998 Nov 27; 273(48):32000-8. Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Brömme D. PMID: 9822672.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    109. Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol. 1998 Sep 15; 161(6):2731-9. Maurer D, Fiebiger E, Reininger B, Ebner C, Petzelbauer P, Shi GP, Chapman HA, Stingl G. PMID: 9743330.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    110. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest. 1998 Aug 01; 102(3):576-83. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. PMID: 9691094.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCells
    111. Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest. 1998 Jun 01; 101(11):2351-63. Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA. PMID: 9616206.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    112. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med. 1998 Jun; 157(6 Pt 1):1770-8. Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, O'DONNELL WJ, Reilly JJ, Ginns L, Mentzer S, Wain J, Speizer FE. PMID: 9620904.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
    113. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry. 1998 Apr 14; 37(15):5258-66. Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Brömme D, Chapman HA, Silverman GA. PMID: 9548757.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    114. Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. J Pharmacol Exp Ther. 1998 Feb; 284(2):751-9. Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA. PMID: 9454824.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    115. Endosomal proteolysis and MHC class II function. Curr Opin Immunol. 1998 Feb; 10(1):93-102. Chapman HA. PMID: 9523118.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    116. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr Opin Cell Biol. 1997 Oct; 9(5):714-24. Chapman HA. PMID: 9330876.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    117. Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J Exp Med. 1997 Aug 18; 186(4):549-60. Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL. PMID: 9254653.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    118. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest. 1997 Jul 01; 100(1):58-67. Waltz DA, Natkin LR, Fujita RM, Wei Y, Chapman HA. PMID: 9202057.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    119. Structure and chromosomal assignment of the human cathepsin K gene. Genomics. 1997 Apr 15; 41(2):258-62. Gelb BD, Shi GP, Heller M, Weremowicz S, Morton C, Desnick RJ, Chapman HA. PMID: 9143502.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    120. Emerging roles for cysteine proteases in human biology. Annu Rev Physiol. 1997; 59:63-88. Chapman HA, Riese RJ, Shi GP. PMID: 9074757.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansCells
    121. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood. 1996 Oct 15; 88(8):3185-94. Simon DI, Rao NK, Xu H, Wei Y, Majdic O, Ronne E, Kobzik L, Chapman HA. PMID: 8874219.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    122. Regulation of integrin function by the urokinase receptor. Science. 1996 Sep 13; 273(5281):1551-5. Wei Y, Lukashev M, Simon DI, Bodary SC, Rosenberg S, Doyle MV, Chapman HA. PMID: 8703217.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    123. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science. 1996 Aug 30; 273(5279):1236-8. Gelb BD, Shi GP, Chapman HA, Desnick RJ. PMID: 8703060.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    124. Mechanisms of pertussis toxin-induced myelomonocytic cell adhesion: role of Mac-1(CD11b/CD18) and urokinase receptor (CD87). Immunology. 1996 May; 88(1):90-7. Wong WS, Simon DI, Rosoff PM, Rao NK, Chapman HA. PMID: 8707356.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    125. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity. 1996 Apr; 4(4):357-66. Riese RJ, Wolf PR, Brömme D, Natkin LR, Villadangos JA, Ploegh HL, Chapman HA. PMID: 8612130.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    126. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. Biochem J. 1995 Oct 01; 311 ( Pt 1):299-305. Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. PMID: 7575468.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    127. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J Clin Invest. 1995 Jul; 96(1):465-74. Rao NK, Shi GP, Chapman HA. PMID: 7615819.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    128. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am J Pathol. 1995 Apr; 146(4):848-60. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. PMID: 7717452.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    129. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. FEBS Lett. 1995 Jan 03; 357(2):129-34. Shi GP, Chapman HA, Bhairi SM, DeLeeuw C, Reddy VY, Weiss SJ. PMID: 7805878.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    130. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem. 1994 Dec 23; 269(51):32380-8. Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA. PMID: 7528215.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    131. The role of thiol proteases in tissue injury and remodeling. Am J Respir Crit Care Med. 1994 Dec; 150(6 Pt 2):S155-9. Chapman HA, Munger JS, Shi GP. PMID: 7952652.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    132. Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy. J Biol Chem. 1994 May 20; 269(20):14746-50. Waltz DA, Chapman HA. PMID: 7514182.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    133. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem. 1994 Apr 15; 269(15):11530-6. Shi GP, Webb AC, Foster KE, Knoll JH, Lemere CA, Munger JS, Chapman HA. PMID: 8157683.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    134. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J Clin Invest. 1993 Sep; 92(3):1572-9. Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CN. PMID: 8376607.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    135. Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors. J Clin Invest. 1993 Apr; 91(4):1541-52. Waltz DA, Sailor LZ, Chapman HA. PMID: 8386190.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    136. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J Biol Chem. 1992 Apr 15; 267(11):7258-62. Shi GP, Munger JS, Meara JP, Rich DH, Chapman HA. PMID: 1373132.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    137. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. J Biol Chem. 1991 Oct 05; 266(28):18832-8. Munger JS, Shi GP, Mark EA, Chin DT, Gerard C, Chapman HA. PMID: 1918003.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    138. Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L. Am J Physiol. 1991 Aug; 261(2 Pt 1):L41-8. Reilly JJ, Chen P, Sailor LZ, Wilcox D, Mason RW, Chapman HA. PMID: 1872415.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    139. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J Clin Invest. 1991 Mar; 87(3):1091-7. Nusrat AR, Chapman HA. PMID: 1847936.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    140. Role of enzyme receptors and inhibitors in regulating proteolytic activities of macrophages. Ann N Y Acad Sci. 1991; 624:87-96. Chapman HA. PMID: 1648325.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    141. Alveolar macrophage urokinase receptors localize enzyme activity to the cell surface. Am J Physiol. 1990 Dec; 259(6 Pt 1):L432-8. Chapman HA, Bertozzi P, Sailor LZ, Nusrat AR. PMID: 2175557.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    142. Developmental expression of plasminogen activator inhibitor type 1 by human alveolar macrophages. Possible role in lung injury. J Immunol. 1990 Nov 15; 145(10):3398-405. Chapman HA, Yang XL, Sailor LZ, Sugarbaker DJ. PMID: 2230126.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    143. Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages. J Clin Invest. 1990 Jul; 86(1):176-83. Reilly JJ, Chen P, Sailor LZ, Mason RW, Chapman HA. PMID: 2365815.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    144. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med. 1990 Mar 29; 322(13):890-7. Bertozzi P, Astedt B, Zenzius L, Lynch K, LeMaire F, Zapol W, Chapman HA. PMID: 2314423.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    145. Identification of cystatin C, a cysteine proteinase inhibitor, as a major secretory product of human alveolar macrophages in vitro. Am Rev Respir Dis. 1990 Mar; 141(3):698-705. Chapman HA, Reilly JJ, Yee R, Grubb A. PMID: 2310099.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    146. Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages. Biochem J. 1989 Jan 15; 257(2):493-8. Reilly JJ, Mason RW, Chen P, Joseph LJ, Sukhatme VP, Yee R, Chapman HA. PMID: 2930462.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    147. Association between alveolar macrophage plasminogen activator activity and indices of lung function in young cigarette smokers. Am Rev Respir Dis. 1988 Dec; 138(6):1422-8. Reilly JJ, Chapman HA. PMID: 3202497.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    148. Role of enzymes mediating thrombosis and thrombolysis in lung disease. Chest. 1988 Jun; 93(6):1256-63. Chapman HA, Bertozzi P, Reilly JJ. PMID: 3131071.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    149. In vitro assay of extracellular matrix elastin degradation. J Biochem Biophys Methods. 1988 Mar; 15(5):283-9. Chapman HA, Ehrhardt MM, Crombie G, Duffy LK. PMID: 3379243.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    150. Role of plasminogen activator in degradation of extracellular matrix protein by live human alveolar macrophages. Am Rev Respir Dis. 1988 Feb; 137(2):412-9. Chapman HA, Reilly JJ, Kobzik L. PMID: 3341631.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    151. Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease. Am Rev Respir Dis. 1986 Mar; 133(3):437-43. Chapman HA, Allen CL, Stone OL. PMID: 3954252.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    152. Elastinolytic activity of human cathepsin L. Biochem J. 1986 Feb 01; 233(3):925-7. Mason RW, Johnson DA, Barrett AJ, Chapman HA. PMID: 3518704.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    153. A fibrinolytic inhibitor of human alveolar macrophages. Induction with endotoxin. Am Rev Respir Dis. 1985 Sep; 132(3):569-75. Chapman HA, Stone OL. PMID: 3898943.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    154. Characterization of a macrophage-derived plasminogen-activator inhibitor. Similarities with placental urokinase inhibitor. Biochem J. 1985 Aug 15; 230(1):109-16. Chapman HA, Stone OL. PMID: 2932100.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    155. Human alveolar macrophages synthesize factor VII in vitro. Possible role in interstitial lung disease. J Clin Invest. 1985 Jun; 75(6):2030-7. Chapman HA, Allen CL, Stone OL, Fair DS. PMID: 4008651.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    156. Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors. J Clin Invest. 1984 Nov; 74(5):1693-700. Chapman HA, Stone OL. PMID: 6568228.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    157. Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages. Biochem J. 1984 Sep 15; 222(3):721-8. Chapman HA, Stone OL. PMID: 6237643.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    158. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation. J Clin Invest. 1984 Mar; 73(3):806-15. Chapman HA, Stone OL, Vavrin Z. PMID: 6368589.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    159. Coordinate expression of macrophage procoagulant and fibrinolytic activity in vitro and in vivo. J Immunol. 1983 Jan; 130(1):261-6. Chapman HA, Vavrin Z, Hibbs JB. PMID: 6847882.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    160. Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor. Cell. 1982 Mar; 28(3):653-62. Chapman HA, Vavrin Z, Hibbs JB. PMID: 6210439.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    161. Modulation of plasminogen activator secretion by activated macrophages: influence of serum factors and correlation with tumoricidal potential. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):3899-903. Chapman HA, Vavrin Z, Hibbs JB. PMID: 291048.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    162. Ontogeny of Peyer's patches and immunoglobulin-containing cells in pigs. J Immunol. 1974 Feb; 112(2):555-63. Chapman HA, Johnson JS, Cooper MD. PMID: 4591974.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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