Sze Chun Winson Ho, MD

Title(s)Assistant Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 Third Street, #473
San Francisco CA 94158
Phone--
ORCID ORCID Icon0000-0001-5943-1436 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Yale College, New Haven, CTBA05/2006Biology
    Yale School of Medicine, New Haven, CTMD05/2011Medicine
    National Institutes of Health, Bethesda, MD06/2018Clinical Fellow in Neurosurgery
    University of Virginia, Charlottesville. VA06/2018Residency in Neurosurgery
    University of Utah, Salt Lake City, UT06/2019Fellow in Pediatric Neurosurgery
    Collapse Awards and Honors
    Yale University2000William Belknap Prize for excellence in biological studies
    Yale School of Medicine2010Medical Student Research Fellowship Award
    NIH/NINDS2019  - 2021Neurosurgeon Research Career Development Program K12
    AANS/CNS Joint Section2020  - 2021Pediatric Section Research Award
    Rally Foundation2020  - 2021Independent Investigator Grant

    Collapse Overview 
    Collapse Overview
    Dr. Winson Ho is a board certified pediatric neurosurgeon. His clinical work covers the whole spectrum of pediatric neurosurgery with a special interest in the neurosurgical care of children with brain tumors, epilepsy, and trauma. His laboratory research focuses on developing novel immunotherapies for the treatment of brain tumors, with a particular interest in studying the role of Protein Phosphatase 2A (PP2A) in modulating anti-tumor immunity. He received his M.D. from Yale University School of Medicine and completed his residency in the joint neurosurgery program of the University of Virginia and the National Institutes of Health. Following his residency, he completed a fellowship in pediatric neurosurgery at Intermountain Primary Children’s Medical Center at the University of Utah in Salt Lake City. He was an Assistant Professor in Neurosurgery at University of Texas at Austin from 2019-2022 prior to joining UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Protein Phosphatase 2A (PP2A) Inhibition to Enhance cGAS-STING Mediated Tumor Immunogenicity in Medulloblastoma
    Matthew Larson Pedaitric Brain Tumor Foundation P0567414May 1, 2023 - Apr 30, 2024
    Role: Principal Investigator
    Description: Study the role of PP2A in modulating tumor immunogenicity in medulloblastoma
    Regulation of Tumor Immunogenicity in Glioblastoma
    NIH/NINDS 1R01NS131545Apr 1, 2023 - Feb 29, 2028
    Role: Principal Investigator
    Description: Glioblastoma (GBM) is an incurable disease with current treatment including surgery, chemotherapy, and radiation. Immunotherapy has thus far failed in clinical trials for GBM. Our studies provide a novel therapeutics target, PP2A, in glioma cells to enhance GBM immunogenicity and sensitivity to immunotherapy.
    Modulation of Protein Phosphatase 2A (PP2A) in Natural-Killer Cell Based Immunotherapy for Pediatric High-Grade Glioma and Diffuse Intrinsic Pontine Glioma
    NIH/NINDS Sub award of K12NS080223Jul 1, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Description: Study the role of PP2A in modulating NK anti-tumor immunity in pediatric high grade glioma and diffuse intrinsic pontine glioma
    PP2A Inhibition in Natural-Killer cell Immunotherapy for Medulloblastoma
    Rally Foundation Independent Investigator GrantJul 1, 2020 - Jun 30, 2021
    Role: Principal Investigator
    Description: Study the role of PP2A in modulating NK anti-tumor immunity in medulloblastoma
    National Killer Cells in Medulloblastoma Metastasis
    AANS/CNS Pediatric Section AwardJul 1, 2020 - Jun 30, 2021
    Role: Principal Investigator
    Description: Study the role of NK cells in controlling medulloblastoma metastasis

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    Collapse Featured Publications

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diffuse intrinsic pontine glioma (DIPG): A review of current and emerging treatment strategies. Cancer Lett. 2024 Apr 10; 590:216876. Weisbrod LJ, Thiraviyam A, Vengoji R, Shonka N, Jain M, Ho W, Batra SK, Salehi A. PMID: 38609002.
      View in: PubMed   Mentions:
    2. Glioma-Immune Cell Crosstalk in Tumor Progression. Cancers (Basel). 2024 Jan 11; 16(2). Elguindy M, Young JS, Mondal I, Lu RO, Ho WS. . PMID: 38254796; PMCID: PMC10813573.
      View in: PubMed   Mentions:
    3. Neoadjuvant Chemotherapy with Laser Interstitial Thermal Therapy in Central Nervous System Neuroblastoma: Illustrative Case and Literature Review. Brain Sci. 2023 Oct 26; 13(11). Chung JE, Iqbal O, Krishnan C, Harrod V, Tyler-Kabara E, Lu RO, Ho WS. PMID: 38002476; PMCID: PMC10669297.
      View in: PubMed   Mentions:
    4. PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma. Cancer Res. 2023 08 01; 83(15):2527-2542. Mondal I, Das O, Sun R, Gao J, Yu B, Diaz A, Behnan J, Dubey A, Meng Z, Eskandar E, Xu B, Lu RO, Ho WS. PMID: 37219874; PMCID: PMC10525036.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages. J Clin Invest. 2023 03 15; 133(6). Ho WS, Mondal I, Xu B, Das O, Sun R, Chiou P, Cai X, Tahmasebinia F, McFadden E, Wu CY, Wu Z, Matsui W, Lim M, Meng Z, Lu RO. PMID: 36757811; PMCID: PMC10014107.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. New Developments in the Pathogenesis, Therapeutic Targeting, and Treatment of Pediatric Medulloblastoma. Cancers (Basel). 2022 May 03; 14(9). Fang FY, Rosenblum JS, Ho WS, Heiss JD. PMID: 35565414; PMCID: PMC9100249.
      View in: PubMed   Mentions: 11  
    7. Targeting Mitochondrial Oxidative Phosphorylation in Glioblastoma Therapy. Neuromolecular Med. 2022 03; 24(1):18-22. Wu Z, Ho WS, Lu R. PMID: 34487301.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    8. MRI-guided laser interstitial thermal therapy using the Visualase system and Navigus frameless stereotaxy in an infant: technical case report. J Neurosurg Pediatr. 2021 May 21; 28(1):50-53. Lee JJ, Clarke D, Hoverson E, Tyler-Kabara EC, Ho WS. PMID: 34020419.
      View in: PubMed   Mentions: 4     Fields:    
    9. Mitochondrial Dysfunction, Macrophage, and Microglia in Brain Cancer. Front Cell Dev Biol. 2020; 8:620788. Lu RO, Ho WS. PMID: 33520994; PMCID: PMC7843701.
      View in: PubMed   Mentions: 9  
    10. Extreme Lateral Transodontoid Approach for Resection of Clival Chordoma: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2020 Sep 01; 19(3):E298. Joyce EJ, Cohen MA, Ho W, Brockmeyer DL, Couldwell WT. PMID: 31943094.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Induction of Immune Response Against Metastatic Tumors via Vaccination of Mannan-BAM, TLR Ligands and Anti-CD40 Antibody (MBTA). Adv Ther (Weinh). 2020 Sep; 3(9). Medina R, Wang H, Caisová V, Cui J, Indig IH, Uher O, Ye J, Nwankwo A, Sanchez V, Wu T, Nduom E, Heiss J, Gilbert MR, Terabe M, Ho W, Zenka J, Pacak K, Zhuang Z. PMID: 33709018; PMCID: PMC7942838.
      View in: PubMed   Mentions: 8  
    12. Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma. J Neurooncol. 2020 Jun; 148(2):231-244. Maggio D, Ho WS, Breese R, Walbridge S, Wang H, Cui J, Heiss JD, Gilbert MR, Kovach JS, Lu RO, Zhuang Z. PMID: 32342332; PMCID: PMC7467059.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    13. A comparison of the accuracy of fetal MRI and prenatal ultrasonography at predicting lesion level and perinatal motor outcome in patients with myelomeningocele. Neurosurg Focus. 2019 10 01; 47(4):E4. Sherrod BA, Ho WS, Hedlund A, Kennedy A, Ostrander B, Bollo RJ. PMID: 31574478.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 Jul 04; 7(1):167. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Group. PMID: 31272507; PMCID: PMC6610889.
      View in: PubMed   Mentions: 5     Fields:    
    15. Small posterior fossa in Chiari I malformation affected families is significantly linked to 1q43-44 and 12q23-24.11 using whole exome sequencing. Eur J Hum Genet. 2019 10; 27(10):1599-1610. Musolf AM, Ho WSC, Long KA, Zhuang Z, Argersinger DP, Sun H, Moiz BA, Simpson CL, Mendelevich EG, Bogdanov EI, Bailey-Wilson JE, Heiss JD. PMID: 31227808; PMCID: PMC6777520.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    16. Complex Chiari malformation: using craniovertebral junction metrics to guide treatment. Childs Nerv Syst. 2019 10; 35(10):1847-1851. Ho WSC, Brockmeyer DL. PMID: 31139903.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop. J Immunother Cancer. 2019 05 22; 7(1):131. Bedognetti D, Ceccarelli M, Galluzzi L, Lu R, Palucka K, Samayoa J, Spranger S, Warren S, Wong KK, Ziv E, Chowell D, Coussens LM, De Carvalho DD, DeNardo DG, Galon J, Kaufman HL, Kirchhoff T, Lotze MT, Luke JJ, Minn AJ, Politi K, Shultz LD, Simon R, Thórsson V, Weidhaas JB, Ascierto ML, Ascierto PA, Barnes JM, Barsan V, Bommareddy PK, Bot A, Church SE, Ciliberto G, De Maria A, Draganov D, Ho WS, McGee HM, Monette A, Murphy JF, Nisticò P, Park W, Patel M, Quigley M, Radvanyi L, Raftopoulos H, Rudqvist NP, Snyder A, Sweis RF, Valpione S, Zappasodi R, Butterfield LH, Disis ML, Fox BA, Cesano A, Marincola FM, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Group. PMID: 31113486; PMCID: PMC6529999.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    18. Severe cranial deformity following cerebrospinal fluid diversion in an adolescent with osteogenesis imperfecta. J Neurosurg Pediatr. 2018 Oct; 22(4):348-351. Ho WS, Jane JA. PMID: 29979129.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade. Nat Commun. 2018 05 29; 9(1):2126. Ho WS, Wang H, Maggio D, Kovach JS, Zhang Q, Song Q, Marincola FM, Heiss JD, Gilbert MR, Lu R, Zhuang Z. PMID: 29844427; PMCID: PMC5974350.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    20. LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation. Cancer Lett. 2018 02 28; 415:217-226. Ho WS, Sizdahkhani S, Hao S, Song H, Seldomridge A, Tandle A, Maric D, Kramp T, Lu R, Heiss JD, Camphausen K, Gilbert MR, Zhuang Z, Park DM. PMID: 29199006; PMCID: PMC5748254.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    21. A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors. Sci Rep. 2016 11 10; 6:36670. Xu H, Li Z, Yu Y, Sizdahkhani S, Ho WS, Yin F, Wang L, Zhu G, Zhang M, Jiang L, Zhuang Z, Qin J. PMID: 27830712; PMCID: PMC5103210.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    22. PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells. Oncotarget. 2016 Mar 15; 7(11):12447-63. Ho WS, Feldman MJ, Maric D, Amable L, Hall MD, Feldman GM, Ray-Chaudhury A, Lizak MJ, Vera JC, Robison RA, Zhuang Z, Heiss JD. PMID: 26799670; PMCID: PMC4914297.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    23. Characterization of the blood brain barrier in pediatric central nervous system neoplasms. J Interdiscip Histopathol. 2016; 4(2):29-33. Hong CS, Ho W, Piazza MG, Ray-Chaudhury A, Zhuang Z, Heiss JD. PMID: 27917302; PMCID: PMC5132180.
      View in: PubMed   Mentions: 9  
    24. Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma. Mol Cancer Ther. 2015 Jul; 14(7):1540-1547. Gordon IK, Lu J, Graves CA, Huntoon K, Frerich JM, Hanson RH, Wang X, Hong CS, Ho W, Feldman MJ, Ikejiri B, Bisht K, Chen XS, Tandle A, Yang C, Arscott WT, Ye D, Heiss JD, Lonser RR, Camphausen K, Zhuang Z. PMID: 25939762; PMCID: PMC4497833.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    25. LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential. Cancer Biol Ther. 2015; 16(6):821-33. Hong CS, Ho W, Zhang C, Yang C, Elder JB, Zhuang Z. PMID: 25897893; PMCID: PMC4623051.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    26. Endovascular intervention for delayed stenosis of extracranial-intracranial bypass saphenous vein grafts. J Neurointerv Surg. 2013 May; 5(3):231-6. Qahwash O, Alaraj A, Aletich V, Charbel FT, Bulsara KR, Ho W, Valyi-Nagy T, Amin-Hanjani S. PMID: 22490431.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biol Psychiatry. 2012 Mar 01; 71(5):392-402. Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, Raubeson MJ, Song Y, Yasuno K, Ho WS, Bilguvar K, Glessner J, Chu SH, Leckman JF, King RA, Gilbert DL, Heiman GA, Tischfield JA, Hoekstra PJ, Devlin B, Hakonarson H, Mane SM, Günel M, State MW. PMID: 22169095; PMCID: PMC3282144.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    28. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature. 2010 Sep 09; 467(7312):207-10. Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoglu D, Tüysüz B, Caglayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioglu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandas S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW, Günel M. PMID: 20729831; PMCID: PMC3129007.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    29. Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expression. J Comp Neurol. 2009 Oct 20; 516(6):456-81. van den Pol AN, Ozduman K, Wollmann G, Ho WS, Simon I, Yao Y, Rose JK, Ghosh P. PMID: 19672982; PMCID: PMC2919849.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    30. Bystander attenuation of neuronal and astrocyte intercellular communication by murine cytomegalovirus infection of glia. J Virol. 2007 Jul; 81(13):7286-92. Ho WS, van den Pol AN. PMID: 17459923; PMCID: PMC1933277.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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