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Jacob Young, MD

Title(s)Resident Physician, Neurological Surgery
SchoolSchool of Medicine
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    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Duke University, Durham, NCBS05/2012Neuroscience
    University of Chicago, Chicago, ILMD06/2017Medicine
    Collapse Awards and Honors
    UCSF Department of Neurological Surgery2019Howard Naffziger Award
    UCSF Department of Neurological Surgery2019Best Junior Research Paper Award
    San Francisco General Hospital, UCSF2018Krevans Award for Excellence in Patient Care
    University of Chicago Pritzker School of Medicine2017Alpha Omega Alpha Honor Society
    University of Chicago Pritzker School of Medicine2017Outstanding Achievement Award in Medicine
    University of Chicago Pritzker School of Medicine2017Graduation with Honors
    University of Chicago Pritzker School of Medicine2017Peter Huttenlocher & Douglas Buchanan Prize
    University of Chicago Pritzker School of Medicine2017Departmental Award for Outstanding Performance in Surgery
    American College of Surgeons (ACS) Clinical Congress 201520153rd Place, Best Medical Student Basic Science Poster
    Neurosurgery Research & Education Foundation (NREF)/American Association of Neurological Surgeons2015Medical Student Summer Research Fellowship
    University of Chicago Pritzker School of Medicine2014The Brain Research Foundation Award for Neuroscience
    Duke University2013Phi Beta Kappa
    Duke University2012Graduation with Distinction

    Collapse Overview 
    Collapse Overview
    Jacob Young, MD is a neurosurgery resident (PGY-3) with an interest in neurosurgical oncology. In addition to his prior translational research investigating novel viral and immunological agents for the treatment of high grade gliomas, his clinical research focus is on optimizing functional outcomes and minimizing complications after surgery for intrinsic brain tumors, specifically by understanding the interaction between functional neural pathways and malignant cells. He works closely with mentors Manish Aghi MD PhD and Shawn Hervey-Jumper MD on projects exploring these topics. Jacob’s research accomplishments include receiving the Peter Huttenlocher & Douglas Buchanan Prize and the Brain Research Foundation Award for Neuroscience from the University of Chicago for his work. His work has been funded by the American Association of Neurological Surgeons and the Neurosurgery Research Education Fund. Furthermore, his clinical performance was recognized with the Krevan’s Award for Excellence in Patient Care at the Zuckerberg San Francisco General Hospital following the completion of his intern year and the Howard Naffziger Award for Outstanding Clinical Service and Care to Neurosurgical Patients at UCSF following the completion of his PGY-2 year.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee AT, Faltermeier C, Morshed RA, Young JS, Kakaizada S, Valdivia C, Findlay AM, Tarapore PE, Nagarajan SS, Hervey-Jumper SL, Berger MS. The impact of high functional connectivity network hub resection on language task performance in adult low- and high-grade glioma. J Neurosurg. 2020 Apr 03; 1-11. PMID: 32244221.
      View in: PubMed
    2. Molinaro AM, Hervey-Jumper S, Morshed RA, Young J, Han SJ, Chunduru P, Zhang Y, Phillips JJ, Shai A, Lafontaine M, Crane J, Chandra A, Flanigan P, Jahangiri A, Cioffi G, Ostrom Q, Anderson JE, Badve C, Barnholtz-Sloan J, Sloan AE, Erickson BJ, Decker PA, Kosel ML, LaChance D, Eckel-Passow J, Jenkins R, Villanueva-Meyer J, Rice T, Wrensch M, Wiencke JK, Oberheim Bush NA, Taylor J, Butowski N, Prados M, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Berger MS. Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma. JAMA Oncol. 2020 Feb 06. PMID: 32027343.
      View in: PubMed
    3. Castrellon JJ, Young JS, Dang LC, Cowan RL, Zald DH, Samanez-Larkin GR. Mesolimbic dopamine D2 receptors and neural representations of subjective value. Sci Rep. 2019 Dec 27; 9(1):20229. PMID: 31882947.
      View in: PubMed
    4. Young JS, Morshed RA, Mansoori Z, Cha S, Berger MS. Disruption of Frontal Aslant Tract Is Not Associated with Long-Term Postoperative Language Deficits. World Neurosurg. 2020 Jan; 133:192-195. PMID: 31574328.
      View in: PubMed
    5. Jacob S Young, Andrew Kai-Hong Chan, Jennifer Viner, Sujatha Sankaran, Alvin Y Chan, Dominic Amara, Stephen T Magill, Joseph A Osorio, Lizbeth Gibson, Peter Sanftner, Mariann Ward, Tracy Ward, Stacy Wong, Manish K Aghi, Edward F Chang, Shawn L Hervey-Jumper, Line G Jacques, Philip V Theodosopoulos, Mitchel S Berger, Michael W McDermott. Safe Transitions Pathway for Postcraniotomy Neurological Surgery Patients: High-Value Care That Bypasses the Intensive Care Unit. Neurosurgery. 2019 Sep 1; 66(Supplement_1).
      View in: Publisher Site
    6. Safaee M, Young JS, El-Sayed IH, Theodosopoulos PV. Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery. Cureus. 2019 Aug 30; 11(8):e5537. PMID: 31687310.
      View in: PubMed
    7. Chandra A, Young JS, Dalle Ore C, Dayani F, Lau D, Wadhwa H, Rick JW, Nguyen AT, McDermott MW, Berger MS, Aghi MK. Insurance type impacts the economic burden and survival of patients with newly diagnosed glioblastoma. J Neurosurg. 2019 Jun 21; 1-11. PMID: 31226687.
      View in: PubMed
    8. Aabedi AA, Ahn E, Kakaizada S, Valdivia C, Young JS, Hervey-Jumper H, Zhang E, Sagher O, Weissman DH, Brang D, Hervey-Jumper SL. Assessment of wakefulness during awake craniotomy to predict intraoperative language performance. J Neurosurg. 2019 May 31; 1-8. PMID: 31151102.
      View in: PubMed
    9. Morshed RA, Young JS, Hervey-Jumper SL, Berger MS. The management of low-grade gliomas in adults. J Neurosurg Sci. 2019 Aug; 63(4):450-457. PMID: 30916536.
      View in: PubMed
    10. Morshed RA, Young JS, Safaee M, Sankaran S, Berger MS, McDermott MW, Hervey-Jumper SL. Delirium Risk Factors and Associated Outcomes in a Neurosurgical Cohort: A Case-Control Study. World Neurosurg. 2019 Jun; 126:e930-e936. PMID: 30872201.
      View in: PubMed
    11. Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS. The transcortical equatorial approach for gliomas of the mesial temporal lobe: techniques and functional outcomes. J Neurosurg. 2019 Mar 01; 130(3):822-830. PMID: 29676697.
      View in: PubMed
    12. Young JS, Dayani F, Morshed RA, Okada H, Aghi MK. Immunotherapy for High Grade Gliomas: A Clinical Update and Practical Considerations for Neurosurgeons. World Neurosurg. 2019 Jan 21. PMID: 30677574.
      View in: PubMed
    13. Castrellon JJ, Seaman KL, Crawford JL, Young JS, Smith CT, Dang LC, Hsu M, Cowan RL, Zald DH, Samanez-Larkin GR. Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults. J Neurosci. 2019 01 09; 39(2):321-332. PMID: 30446530.
      View in: PubMed
    14. Kim JW, Kane JR, Panek WK, Young JS, Rashidi A, Yu D, Kanojia D, Hasan T, Miska J, Gómez-Lim MA, Ulasov IV, Balyasnikova IV, Ahmed AU, Wainwright DA, Lesniak MS. A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model. Neurotherapeutics. 2018 10; 15(4):1127-1138. PMID: 30027430.
      View in: PubMed
    15. Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS. Perioperative outcomes following reoperation for recurrent insular gliomas. J Neurosurg. 2018 09 21; 131(2):467-473. PMID: 30239317.
      View in: PubMed
    16. Young JS, Prados MD, Butowski N. Using genomics to guide treatment for glioblastoma. Pharmacogenomics. 2018 10; 19(15):1217-1229. PMID: 30203716.
      View in: PubMed
    17. Kim JW, Chang AL, Kane JR, Young JS, Qiao J, Lesniak MS. Gene Therapy and Virotherapy of Gliomas. Prog Neurol Surg. 2018; 32:112-123. PMID: 29990979.
      View in: PubMed
    18. Young JS, Bernal G, Polster SP, Nunez L, Larsen GF, Mansour N, Podell M, Yamini B. Convection-Enhanced Delivery of Polymeric Nanoparticles Encapsulating Chemotherapy in Canines with Spontaneous Supratentorial Tumors. World Neurosurg. 2018 Sep; 117:e698-e704. PMID: 29960096.
      View in: PubMed
    19. Morshed RA, Young JS, Hervey-Jumper SL. Sharpening the Surgeon's Knife: Value of Extent of Resection for Glioma in Molecular Age. World Neurosurg. 2018 09; 117:350-352. PMID: 29945007.
      View in: PubMed
    20. Dayani F, Young JS, Bonte A, Chang EF, Theodosopoulos P, McDermott MW, Berger MS, Aghi MK. Safety and outcomes of resection of butterfly glioblastoma. Neurosurg Focus. 2018 06; 44(6):E4. PMID: 29852771.
      View in: PubMed
    21. Magill ST, Young JS, Chae R, Aghi MK, Theodosopoulos PV, McDermott MW. Relationship between tumor location, size, and WHO grade in meningioma. Neurosurg Focus. 2018 04; 44(4):E4. PMID: 29606048.
      View in: PubMed
    22. Julius W. Kim, Katarzyna C. Pituch, Annie Xiao, Jacob S. Young, Wojciech K. Panek, Megan E. Muroski, Aida Rashidi, J. Robert Kane, Deepak Kanojia, Maciej S. Lesniak. Chapter 15 Gene/Viral Treatment Approaches for Malignant Brain Cancer. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy. 2018 Jan 1; 211-227.
      View in: Publisher Site
    23. Utevsky AV, Smith DV, Young JS, Huettel SA. Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation. eNeuro. 2017 Sep-Oct; 4(5). PMID: 29034316.
      View in: PubMed
    24. Panek WK, Kane JR, Young JS, Rashidi A, Kim JW, Kanojia D, Lesniak MS. Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma. Oncotarget. 2017 Oct 24; 8(51):89391-89405. PMID: 29179527.
      View in: PubMed
    25. Young JS, Chmura SJ, Wainwright DA, Yamini B, Peters KB, Lukas RV. Management of glioblastoma in elderly patients. J Neurol Sci. 2017 Sep 15; 380:250-255. PMID: 28870580.
      View in: PubMed
    26. Kim JW, Miska J, Young JS, Rashidi A, Kane JR, Panek WK, Kanojia D, Han Y, Balyasnikova IV, Lesniak MS. A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model. Mol Ther Oncolytics. 2017 Jun 16; 5:97-104. PMID: 28573184.
      View in: PubMed
    27. W. K. Panek, Julius W. Kim, Katarzyna C. Pituch, Joshua R. Kane, Deepak Kanojia, Alex Cordero, Jason Miska, Aida Rashidi, Jacob S. Young, Maciej S. Lesniak. P08.46 Synergistic Therapeutic Efficacy via Immunomodulatory Platelet Rich Fibrin Patch (PRF-P) in Combination with Oncolytic Adenovirus for the Treatment of Glioma. Neuro-Oncology. 2017 Apr 1; 19(suppl_3):iii64-iii64.
      View in: Publisher Site
    28. J.W. Kim, J. Murphy, A.L. Chang, D.A. Spencer, J.R. Kane, D. Kanojia, A. Rashidi, J.S. Young, M.S. Lesniak. 19 All Aboard Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy. Mesenchymal Stromal Cells as Tumor Stromal Modulators. 2017 Jan 1; 475-499.
      View in: Publisher Site
    29. Young JS, Hobbs JG, Bailes JE. The Impact of Traumatic Brain Injury on the Aging Brain. Curr Psychiatry Rep. 2016 09; 18(9):81. PMID: 27432348.
      View in: PubMed
    30. Kim JW, Auffinger B, Spencer DA, Miska J, Chang AL, Kane JR, Young JS, Kanojia D, Qiao J, Mann JF, Zhang L, Wu M, Ahmed AU, Aboody KS, Strong TV, Hébert CD, Lesniak MS. Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters. J Transl Med. 2016 05 16; 14(1):134. PMID: 27184224.
      View in: PubMed
    31. Hobbs JG, Young JS, Bailes JE. Sports-related concussions: diagnosis, complications, and current management strategies. Neurosurg Focus. 2016 Apr; 40(4):E5. PMID: 27032922.
      View in: PubMed
    32. Kim JW, Young JS, Solomaha E, Kanojia D, Lesniak MS, Balyasnikova IV. A novel single-chain antibody redirects adenovirus to IL13Ra2-expressing brain tumors. Sci Rep. 2015 Dec 14; 5:18133. PMID: 26656559.
      View in: PubMed
    33. Julius W. Kim, J. Robert Kane, Jacob S. Young, Dou Yu, Jason Miska, Alan L. Chang, Aida Rashidi, Atique Ahmed, Irina Balyasnikova, Maciej S. Lesniak. ATPS-41DENDRITIC CELL BASED IMMUNOTHERAPY OF MALIGNANT GLIOMA VIA A NOVEL CD8a+ DC TARGETED ADENOVIRAL VECTOR. Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v27-v27.
      View in: Publisher Site
    34. Kim JW, Kane JR, Young JS, Chang AL, Kanojia D, Morshed RA, Miska J, Ahmed AU, Balyasnikova IV, Han Y, Zhang L, Curiel DT, Lesniak MS. A Genetically Modified Adenoviral Vector with a Phage Display-Derived Peptide Incorporated into Fiber Fibritin Chimera Prolongs Survival in Experimental Glioma. Hum Gene Ther. 2015 Sep; 26(9):635-46. PMID: 26058317.
      View in: PubMed
    35. Julius W. Kim, Jacob S. Young, Maciej S. Lesniak, Irina V. Balyasnikova. 22. A Novel Single-Chain Antibody for Selective Targeting of IL13Ra2-Expressing Brain Tumors. Molecular Therapy. 2015 May 1; 23:s10.
      View in: Publisher Site
    36. Kim JW, Kane JR, Young JS, Chang AL, Kanojia D, Qian S, Spencer DA, Ahmed AU, Lesniak MS. Neural stem cell-mediated delivery of oncolytic adenovirus. Curr Protoc Hum Genet. 2015 Apr 01; 85:13.11.1-13.11.9. PMID: 25827347.
      View in: PubMed
    37. Young JS, Smith DV, Coutlee CG, Huettel SA. Synchrony between sensory and cognitive networks is associated with subclinical variation in autistic traits. Front Hum Neurosci. 2015; 9:146. PMID: 25852527.
      View in: PubMed
    38. Kane JR, Miska J, Young JS, Kanojia D, Kim JW, Lesniak MS. Sui generis: gene therapy and delivery systems for the treatment of glioblastoma. Neuro Oncol. 2015 Mar; 17 Suppl 2:ii24-ii36. PMID: 25746089.
      View in: PubMed
    39. Spencer DA, Young JS, Kanojia D, Kim JW, Polster SP, Murphy JP, Lesniak MS. Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacy. Ther Deliv. 2015; 6(4):453-68. PMID: 25996044.
      View in: PubMed
    40. Julius W. Kim, J. Robert Kane, Jacob S. Young, Ramin A. Morshed, Alan A. Chang, Atique U. Ahmed, Irina V. Balyasnikova, Maciej S. Lesniak. ET-29AN OPTIMIZED ONCOLYTIC ADENOVIRUS FOR GLIOMA THERAPY: SPECIFIC TARGETING, EFFICIENT INFECTION, AND RESTRICTED REPLICATION IN GLIOMA. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v85-v86.
      View in: Publisher Site
    41. Dang LC, Samanez-Larkin GR, Young JS, Cowan RL, Kessler RM, Zald DH. Caudate asymmetry is related to attentional impulsivity and an objective measure of ADHD-like attentional problems in healthy adults. Brain Struct Funct. 2016 Jan; 221(1):277-86. PMID: 25269835.
      View in: PubMed
    42. Young JS, Morshed RA, Kim JW, Balyasnikova IV, Ahmed AU, Lesniak MS. Advances in stem cells, induced pluripotent stem cells, and engineered cells: delivery vehicles for anti-glioma therapy. Expert Opin Drug Deliv. 2014 Nov; 11(11):1733-46. PMID: 25005767.
      View in: PubMed
    43. Young JS, Kim JW, Ahmed AU, Lesniak MS. Therapeutic cell carriers: a potential road to cure glioma. Expert Rev Neurother. 2014 Jun; 14(6):651-60. PMID: 24852229.
      View in: PubMed
    44. Kessler RM, Seibyl J, Cowan RL, Zald D, Young JS, Ansari MS, Stabin MG. Radiation Dosimetry of (18)F-FPEB in Humans. J Nucl Med. 2014 Jul; 55(7):1119-21. PMID: 24799618.
      View in: PubMed
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