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Jacob Young, MD

Title(s)Resident Physician, Neurological Surgery
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
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    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Duke University, Durham, NCBS05/2012Neuroscience
    University of Chicago, Chicago, ILMD06/2017Medicine
    Collapse Awards and Honors
    San Francisco Neurosurgical Society2020Harold Rosegay Award
    UCSF Department of Neurological Surgery2019Howard Naffziger Award
    UCSF Department of Neurological Surgery2019Best Junior Research Paper Award
    San Francisco General Hospital, UCSF2018Krevans Award for Excellence in Patient Care
    University of Chicago Pritzker School of Medicine2017Alpha Omega Alpha Honor Society
    University of Chicago Pritzker School of Medicine2017Outstanding Achievement Award in Medicine
    University of Chicago Pritzker School of Medicine2017Graduation with Honors
    University of Chicago Pritzker School of Medicine2017Peter Huttenlocher & Douglas Buchanan Prize
    University of Chicago Pritzker School of Medicine2017Departmental Award for Outstanding Performance in Surgery
    American College of Surgeons (ACS) Clinical Congress 201520153rd Place, Best Medical Student Basic Science Poster
    Neurosurgery Research & Education Foundation (NREF)/American Association of Neurological Surgeons2015Medical Student Summer Research Fellowship
    University of Chicago Pritzker School of Medicine2014The Brain Research Foundation Award for Neuroscience
    Duke University2013Phi Beta Kappa
    Duke University2012Graduation with Distinction

    Collapse Overview 
    Collapse Overview
    Jacob Young, MD is a neurosurgery resident (PGY-3) with an interest in neurosurgical oncology. In addition to his prior translational research investigating novel viral and immunological agents for the treatment of high grade gliomas, his clinical research focus is on optimizing functional outcomes and minimizing complications after surgery for intrinsic brain tumors, specifically by understanding the interaction between functional neural pathways and malignant cells. He works closely with mentors Manish Aghi MD PhD and Shawn Hervey-Jumper MD on projects exploring these topics. Jacob’s research accomplishments include receiving the Peter Huttenlocher & Douglas Buchanan Prize and the Brain Research Foundation Award for Neuroscience from the University of Chicago for his work. His work has been funded by the American Association of Neurological Surgeons and the Neurosurgery Research Education Fund. Furthermore, his clinical performance was recognized with the Krevan’s Award for Excellence in Patient Care at the Zuckerberg San Francisco General Hospital following the completion of his intern year and the Howard Naffziger Award for Outstanding Clinical Service and Care to Neurosurgical Patients at UCSF following the completion of his PGY-2 year.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Triple motor mapping: transcranial, bipolar, and monopolar mapping for supratentorial glioma resection adjacent to motor pathways. J Neurosurg. 2020 Jun 05; 1-10. Gogos AJ, Young JS, Morshed RA, Avalos LN, Noss RS, Villanueva-Meyer JE, Hervey-Jumper SL, Berger MS. PMID: 32502996.
      View in: PubMed   Mentions:    Fields:    
    2. Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution. Neurosurg Focus. 2020 Jun; 48(6):E13. Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK. PMID: 32480370.
      View in: PubMed   Mentions:    Fields:    
    3. Molecular characteristics of diffuse lower grade gliomas: what neurosurgeons need to know. Acta Neurochir (Wien). 2020 May 30. Young JS, Gogos AJ, Morshed RA, Hervey-Jumper SL, Berger MS. PMID: 32472378.
      View in: PubMed   Mentions:    Fields:    
    4. A Safe Transitions Pathway for post-craniotomy neurological surgery patients: high-value care that bypasses the intensive care unit. J Neurosurg. 2020 May 29; 1-6. Young JS, Chan AK, Viner JA, Sankaran S, Chan AY, Imershein S, Meary-Miller A, Theodosopoulos PV, Jacques L, Aghi MK, Chang EF, Hervey-Jumper SL, Ward T, Gibson L, Ward MM, Sanftner P, Wong S, Amara D, Magill ST, Osorio JA, Venkatesh B, Gonzales R, Lau C, Boscardin C, Wang M, Berry K, McCullagh L, Reid M, Reels K, Nedkov S, Berger MS, McDermott MW. PMID: 32470928.
      View in: PubMed   Mentions:    Fields:    
    5. The influence of race and socioeconomic status on therapeutic clinical trial screening and enrollment. J Neurooncol. 2020 May; 148(1):131-139. Morshed RA, Reihl SJ, Molinaro AM, Kakaizada S, Young JS, Schulte JD, Butowski N, Taylor J, Bush NA, Aghi MK, Berger MS, Chang S, Clarke J, Hervey-Jumper SL. PMID: 32350780.
      View in: PubMed   Mentions:    Fields:    
    6. Awake glioma surgery: technical evolution and nuances. J Neurooncol. 2020 May; 147(3):515-524. Gogos AJ, Young JS, Morshed RA, Hervey-Jumper SL, Berger MS. PMID: 32270374.
      View in: PubMed   Mentions:    Fields:    
    7. The impact of high functional connectivity network hub resection on language task performance in adult low- and high-grade glioma. J Neurosurg. 2020 Apr 03; 1-11. Lee AT, Faltermeier C, Morshed RA, Young JS, Kakaizada S, Valdivia C, Findlay AM, Tarapore PE, Nagarajan SS, Hervey-Jumper SL, Berger MS. PMID: 32244221.
      View in: PubMed   Mentions:    Fields:    
    8. Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma. JAMA Oncol. 2020 Feb 06. Molinaro AM, Hervey-Jumper S, Morshed RA, Young J, Han SJ, Chunduru P, Zhang Y, Phillips JJ, Shai A, Lafontaine M, Crane J, Chandra A, Flanigan P, Jahangiri A, Cioffi G, Ostrom Q, Anderson JE, Badve C, Barnholtz-Sloan J, Sloan AE, Erickson BJ, Decker PA, Kosel ML, LaChance D, Eckel-Passow J, Jenkins R, Villanueva-Meyer J, Rice T, Wrensch M, Wiencke JK, Oberheim Bush NA, Taylor J, Butowski N, Prados M, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Berger MS. PMID: 32027343.
      View in: PubMed   Mentions: 2     Fields:    
    9. Mesolimbic dopamine D2 receptors and neural representations of subjective value. Sci Rep. 2019 12 27; 9(1):20229. Castrellon JJ, Young JS, Dang LC, Cowan RL, Zald DH, Samanez-Larkin GR. PMID: 31882947.
      View in: PubMed   Mentions:    Fields:    
    10. Disruption of Frontal Aslant Tract Is Not Associated with Long-Term Postoperative Language Deficits. World Neurosurg. 2020 Jan; 133:192-195. Young JS, Morshed RA, Mansoori Z, Cha S, Berger MS. PMID: 31574328.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Safe Transitions Pathway for Postcraniotomy Neurological Surgery Patients: High-Value Care That Bypasses the Intensive Care Unit. Neurosurgery. 2019 Sep 1; 66(Supplement_1). Jacob S Young, Andrew Kai-Hong Chan, Jennifer Viner, Sujatha Sankaran, Alvin Y Chan, Dominic Amara, Stephen T Magill, Joseph A Osorio, Lizbeth Gibson, Peter Sanftner, Mariann Ward, Tracy Ward, Stacy Wong, Manish K Aghi, Edward F Chang, Shawn L Hervey-Jumper, Line G Jacques, Philip V Theodosopoulos, Mitchel S Berger, Michael W McDermott. .
      View in: Publisher Site   Mentions:
    12. Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery. Cureus. 2019 Aug 30; 11(8):e5537. Safaee M, Young JS, El-Sayed IH, Theodosopoulos PV. PMID: 31687310.
      View in: PubMed   Mentions:
    13. Insurance type impacts the economic burden and survival of patients with newly diagnosed glioblastoma. J Neurosurg. 2019 Jun 21; 1-11. Chandra A, Young JS, Dalle Ore C, Dayani F, Lau D, Wadhwa H, Rick JW, Nguyen AT, McDermott MW, Berger MS, Aghi MK. PMID: 31226687.
      View in: PubMed   Mentions:    Fields:    
    14. Assessment of wakefulness during awake craniotomy to predict intraoperative language performance. J Neurosurg. 2019 May 31; 1-8. Aabedi AA, Ahn E, Kakaizada S, Valdivia C, Young JS, Hervey-Jumper H, Zhang E, Sagher O, Weissman DH, Brang D, Hervey-Jumper SL. PMID: 31151102.
      View in: PubMed   Mentions:    Fields:    
    15. The management of low-grade gliomas in adults. J Neurosurg Sci. 2019 Aug; 63(4):450-457. Morshed RA, Young JS, Hervey-Jumper SL, Berger MS. PMID: 30916536.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Delirium Risk Factors and Associated Outcomes in a Neurosurgical Cohort: A Case-Control Study. World Neurosurg. 2019 Jun; 126:e930-e936. Morshed RA, Young JS, Safaee M, Sankaran S, Berger MS, McDermott MW, Hervey-Jumper SL. PMID: 30872201.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. The transcortical equatorial approach for gliomas of the mesial temporal lobe: techniques and functional outcomes. J Neurosurg. 2019 03 01; 130(3):822-830. Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS. PMID: 29676697.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Immunotherapy for High Grade Gliomas: A Clinical Update and Practical Considerations for Neurosurgeons. World Neurosurg. 2019 Jan 21. Young JS, Dayani F, Morshed RA, Okada H, Aghi MK. PMID: 30677574.
      View in: PubMed   Mentions: 1     Fields:    
    19. Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults. J Neurosci. 2019 01 09; 39(2):321-332. Castrellon JJ, Seaman KL, Crawford JL, Young JS, Smith CT, Dang LC, Hsu M, Cowan RL, Zald DH, Samanez-Larkin GR. PMID: 30446530.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model. Neurotherapeutics. 2018 10; 15(4):1127-1138. Kim JW, Kane JR, Panek WK, Young JS, Rashidi A, Yu D, Kanojia D, Hasan T, Miska J, Gómez-Lim MA, Ulasov IV, Balyasnikova IV, Ahmed AU, Wainwright DA, Lesniak MS. PMID: 30027430.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Perioperative outcomes following reoperation for recurrent insular gliomas. J Neurosurg. 2018 09 21; 131(2):467-473. Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS. PMID: 30239317.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Using genomics to guide treatment for glioblastoma. Pharmacogenomics. 2018 10; 19(15):1217-1229. Young JS, Prados MD, Butowski N. PMID: 30203716.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    23. Gene Therapy and Virotherapy of Gliomas. Prog Neurol Surg. 2018; 32:112-123. Kim JW, Chang AL, Kane JR, Young JS, Qiao J, Lesniak MS. PMID: 29990979.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Convection-Enhanced Delivery of Polymeric Nanoparticles Encapsulating Chemotherapy in Canines with Spontaneous Supratentorial Tumors. World Neurosurg. 2018 Sep; 117:e698-e704. Young JS, Bernal G, Polster SP, Nunez L, Larsen GF, Mansour N, Podell M, Yamini B. PMID: 29960096.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCTClinical Trials
    25. Sharpening the Surgeon's Knife: Value of Extent of Resection for Glioma in Molecular Age. World Neurosurg. 2018 09; 117:350-352. Morshed RA, Young JS, Hervey-Jumper SL. PMID: 29945007.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Safety and outcomes of resection of butterfly glioblastoma. Neurosurg Focus. 2018 06; 44(6):E4. Dayani F, Young JS, Bonte A, Chang EF, Theodosopoulos P, McDermott MW, Berger MS, Aghi MK. PMID: 29852771.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Relationship between tumor location, size, and WHO grade in meningioma. Neurosurg Focus. 2018 04; 44(4):E4. Magill ST, Young JS, Chae R, Aghi MK, Theodosopoulos PV, McDermott MW. PMID: 29606048.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Chapter 15 Gene/Viral Treatment Approaches for Malignant Brain Cancer. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy. 2018 Jan 1; 211-227. Julius W. Kim, Katarzyna C. Pituch, Annie Xiao, Jacob S. Young, Wojciech K. Panek, Megan E. Muroski, Aida Rashidi, J. Robert Kane, Deepak Kanojia, Maciej S. Lesniak. .
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    29. Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation. eNeuro. 2017 Sep-Oct; 4(5). Utevsky AV, Smith DV, Young JS, Huettel SA. PMID: 29034316.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma. Oncotarget. 2017 Oct 24; 8(51):89391-89405. Panek WK, Kane JR, Young JS, Rashidi A, Kim JW, Kanojia D, Lesniak MS. PMID: 29179527.
      View in: PubMed   Mentions: 8     Fields:    
    31. Management of glioblastoma in elderly patients. J Neurol Sci. 2017 Sep 15; 380:250-255. Young JS, Chmura SJ, Wainwright DA, Yamini B, Peters KB, Lukas RV. PMID: 28870580.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    32. A Comparative Study of Replication-Incompetent and -Competent Adenoviral Therapy-Mediated Immune Response in a Murine Glioma Model. Mol Ther Oncolytics. 2017 Jun 16; 5:97-104. Kim JW, Miska J, Young JS, Rashidi A, Kane JR, Panek WK, Kanojia D, Han Y, Balyasnikova IV, Lesniak MS. PMID: 28573184.
      View in: PubMed   Mentions:
    33. P08.46 Synergistic Therapeutic Efficacy via Immunomodulatory Platelet Rich Fibrin Patch (PRF-P) in Combination with Oncolytic Adenovirus for the Treatment of Glioma. Neuro-Oncology. 2017 Apr 1; 19(suppl_3):iii64-iii64. W. K. Panek, Julius W. Kim, Katarzyna C. Pituch, Joshua R. Kane, Deepak Kanojia, Alex Cordero, Jason Miska, Aida Rashidi, Jacob S. Young, Maciej S. Lesniak. .
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    34. 19 All Aboard Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy. Mesenchymal Stromal Cells as Tumor Stromal Modulators. 2017 Jan 1; 475-499. J.W. Kim, J. Murphy, A.L. Chang, D.A. Spencer, J.R. Kane, D. Kanojia, A. Rashidi, J.S. Young, M.S. Lesniak. .
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    35. The Impact of Traumatic Brain Injury on the Aging Brain. Curr Psychiatry Rep. 2016 09; 18(9):81. Young JS, Hobbs JG, Bailes JE. PMID: 27432348.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters. J Transl Med. 2016 05 16; 14(1):134. Kim JW, Auffinger B, Spencer DA, Miska J, Chang AL, Kane JR, Young JS, Kanojia D, Qiao J, Mann JF, Zhang L, Wu M, Ahmed AU, Aboody KS, Strong TV, Hébert CD, Lesniak MS. PMID: 27184224.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    37. Sports-related concussions: diagnosis, complications, and current management strategies. Neurosurg Focus. 2016 Apr; 40(4):E5. Hobbs JG, Young JS, Bailes JE. PMID: 27032922.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. A novel single-chain antibody redirects adenovirus to IL13Ra2-expressing brain tumors. Sci Rep. 2015 Dec 14; 5:18133. Kim JW, Young JS, Solomaha E, Kanojia D, Lesniak MS, Balyasnikova IV. PMID: 26656559.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. ATPS-41DENDRITIC CELL BASED IMMUNOTHERAPY OF MALIGNANT GLIOMA VIA A NOVEL CD8a+ DC TARGETED ADENOVIRAL VECTOR. Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v27-v27. Julius W. Kim, J. Robert Kane, Jacob S. Young, Dou Yu, Jason Miska, Alan L. Chang, Aida Rashidi, Atique Ahmed, Irina Balyasnikova, Maciej S. Lesniak. .
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    40. A Genetically Modified Adenoviral Vector with a Phage Display-Derived Peptide Incorporated into Fiber Fibritin Chimera Prolongs Survival in Experimental Glioma. Hum Gene Ther. 2015 Sep; 26(9):635-46. Kim JW, Kane JR, Young JS, Chang AL, Kanojia D, Morshed RA, Miska J, Ahmed AU, Balyasnikova IV, Han Y, Zhang L, Curiel DT, Lesniak MS. PMID: 26058317.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    41. 22. A Novel Single-Chain Antibody for Selective Targeting of IL13Ra2-Expressing Brain Tumors. Molecular Therapy. 2015 May 1; 23:s10. Julius W. Kim, Jacob S. Young, Maciej S. Lesniak, Irina V. Balyasnikova. .
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    42. Neural stem cell-mediated delivery of oncolytic adenovirus. Curr Protoc Hum Genet. 2015 Apr 01; 85:13.11.1-13.11.9. Kim JW, Kane JR, Young JS, Chang AL, Kanojia D, Qian S, Spencer DA, Ahmed AU, Lesniak MS. PMID: 25827347.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    43. Synchrony between sensory and cognitive networks is associated with subclinical variation in autistic traits. Front Hum Neurosci. 2015; 9:146. Young JS, Smith DV, Coutlee CG, Huettel SA. PMID: 25852527.
      View in: PubMed   Mentions:
    44. Sui generis: gene therapy and delivery systems for the treatment of glioblastoma. Neuro Oncol. 2015 Mar; 17 Suppl 2:ii24-ii36. Kane JR, Miska J, Young JS, Kanojia D, Kim JW, Lesniak MS. PMID: 25746089.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    45. Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacy. Ther Deliv. 2015; 6(4):453-68. Spencer DA, Young JS, Kanojia D, Kim JW, Polster SP, Murphy JP, Lesniak MS. PMID: 25996044.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. ET-29AN OPTIMIZED ONCOLYTIC ADENOVIRUS FOR GLIOMA THERAPY: SPECIFIC TARGETING, EFFICIENT INFECTION, AND RESTRICTED REPLICATION IN GLIOMA. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v85-v86. Julius W. Kim, J. Robert Kane, Jacob S. Young, Ramin A. Morshed, Alan A. Chang, Atique U. Ahmed, Irina V. Balyasnikova, Maciej S. Lesniak. .
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    47. Caudate asymmetry is related to attentional impulsivity and an objective measure of ADHD-like attentional problems in healthy adults. Brain Struct Funct. 2016 Jan; 221(1):277-86. Dang LC, Samanez-Larkin GR, Young JS, Cowan RL, Kessler RM, Zald DH. PMID: 25269835.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    48. Advances in stem cells, induced pluripotent stem cells, and engineered cells: delivery vehicles for anti-glioma therapy. Expert Opin Drug Deliv. 2014 Nov; 11(11):1733-46. Young JS, Morshed RA, Kim JW, Balyasnikova IV, Ahmed AU, Lesniak MS. PMID: 25005767.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    49. Therapeutic cell carriers: a potential road to cure glioma. Expert Rev Neurother. 2014 Jun; 14(6):651-60. Young JS, Kim JW, Ahmed AU, Lesniak MS. PMID: 24852229.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    50. Radiation Dosimetry of (18)F-FPEB in Humans. J Nucl Med. 2014 Jul; 55(7):1119-21. Kessler RM, Seibyl J, Cowan RL, Zald D, Young JS, Ansari MS, Stabin MG. PMID: 24799618.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
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