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Aaron Diaz, PhD

Title(s)Associate Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 3rd Street
San Francisco CA 94158
Phone415-514-0408
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    New York UniversityBA1997Mathematics
    Cornell UniversityMS2003Computer Science
    Cornell UniversityPhD2003Applied Mathematics

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    The Diaz Lab is interested in developing targeted therapeutics for the treatment of glioma. We apply molecular and computational approaches to elucidate targets and pathways mediating cancer progression. To date, some of the most effective cancer therapies have been those that hone in on molecular defects associated with specific driver genes. However, in highly diverse tumors, such as gliomas, clinical trials of promising targeted therapeutics often produce mixed results. This is at least partially due to intra-tumor regional heterogeneity in response to treatment. To address this pressing challenge, we combine high-throughput single-cell sequencing with state-of-the-art machine-learning algorithms, to produce quantitative models of tumor heterogeneity and micro-environment interaction. Moreover, brain tumor cells can exhibit phenotypes, and molecular signatures, of cell types found in the developing brain. We are also interested in the role of early-brain developmental programs in brain tumor growth.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Exosomal PD-L1 induces immunosuppressive nonclassical monocytes. Neuro Oncol. 2020 Jul 07; 22(7):901-902. Diaz AA. PMID: 32296839.
      View in: PubMed   Mentions:    Fields:    
    2. Ensemble learning for classifying single-cell data and projection across reference atlases. Bioinformatics. 2020 Jun 01; 36(11):3585-3587. Wang L, Catalan F, Shamardani K, Babikir H, Diaz A. PMID: 32105316.
      View in: PubMed   Mentions:    Fields:    
    3. Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance. Cancer Res. 2020 Apr 01; 80(7):1498-1511. Chandra A, Jahangiri A, Chen W, Nguyen AT, Yagnik G, Pereira MP, Jain S, Garcia JH, Shah SS, Wadhwa H, Joshi RS, Weiss J, Wolf KJ, Lin JG, Müller S, Rick JW, Diaz AA, Gilbert LA, Kumar S, Aghi MK. PMID: 32041837.
      View in: PubMed   Mentions:    Fields:    
    4. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 01 02; 26(1):48-63.e6. Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. PMID: 31901251.
      View in: PubMed   Mentions: 5     Fields:    
    5. The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation. Cancer Discov. 2019 12; 9(12):1708-1719. Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA. PMID: 31554641.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019 07 17; 103(2):309-322.e7. Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY. PMID: 31151773.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones. Bioinformatics. 2018 09 15; 34(18):3217-3219. Müller S, Cho A, Liu SJ, Lim DA, Diaz A. PMID: 29897414.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    8. CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones. Bioinformatics. 2018. S. Müller, A. Cho, S. Liu, D. Lim, A. Diaz.. View Publication.
    9. Peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas. JCI Insight. 2018 04 05; 3(7). Müller S, Agnihotri S, Shoger KE, Myers MI, Smith N, Chaparala S, Villanueva CR, Chattopadhyay A, Lee AV, Butterfield LH, Diaz A, Okada H, Pollack IF, Kohanbash G. PMID: 29618666.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    10. The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output. Cell Stem Cell. 2018 03 01; 22(3):369-383.e8. Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M. PMID: 29499153.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. Genome Biol. 2017 Dec 20; 18(1):234. Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A. PMID: 29262845.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    12. Single-Cell mRNA Sequencing in Cancer Research: Integrating the Genomic Fingerprint. Front Genet. 2017; 8:73. Müller S, Diaz A. PMID: 28620412.
      View in: PubMed   Mentions:
    13. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25; 12(11):889. Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A. PMID: 27888226.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    14. SCell: integrated analysis of single-cell RNA-seq data. Bioinformatics. 2016 07 15; 32(14):2219-20. Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A. PMID: 27153637.
      View in: PubMed   Mentions: 14     Fields:    
    15. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA. PMID: 27081004.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    16. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. PMID: 26653140.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Molecular identity of human outer radial glia during cortical development. Cell. 2015 Sep 24; 163(1):55-67. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR. PMID: 26406371.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    18. HiTSelect: a comprehensive tool for high-complexity-pooled screen analysis. Nucleic Acids Res. 2015 Feb 18; 43(3):e16. Diaz AA, Qin H, Ramalho-Santos M, Song JS. PMID: 25428347.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    19. Systematic identification of barriers to human iPSC generation. Cell. 2014 Jul 17; 158(2):449-461. Qin H, Diaz A, Blouin L, Lebbink RJ, Patena W, Tanbun P, LeProust EM, McManus MT, Song JS, Ramalho-Santos M. PMID: 25036638.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    20. Recurrent epimutations activate gene body promoters in primary glioblastoma. Genome Res. 2014 May; 24(5):761-74. Nagarajan RP, Zhang B, Bell RJ, Johnson BE, Olshen AB, Sundaram V, Li D, Graham AE, Diaz A, Fouse SD, Smirnov I, Song J, Paris PL, Wang T, Costello JF. PMID: 24709822.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    21. Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo. Cell Stem Cell. 2013 May 02; 12(5):616-28. Ramos AD, Diaz A, Nellore A, Delgado RN, Park KY, Gonzales-Roybal G, Oldham MC, Song JS, Lim DA. PMID: 23583100.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    22. NSeq: a multithreaded Java application for finding positioned nucleosomes from sequencing data. Front Genet. 2012; 3:320. Nellore A, Bobkov K, Howe E, Pankov A, Diaz A, Song JS. PMID: 23335939.
      View in: PubMed   Mentions:
    23. Genome Biology. CHANCE: comprehensive software for quality control and validation of ChIP-seq data. 2012; 13(10). Diaz A, Nellore A, Song J S.
    24. Normalization, bias correction, and peak calling for ChIP-seq. Stat Appl Genet Mol Biol. 2012 Mar 31; 11(3):Article 9. Diaz A, Park K, Lim DA, Song JS. PMID: 22499706.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    25. Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 2012; 8(3):e1002576. Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF. PMID: 22438827.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    26. Proceedings of the 4th WSEAS/IASME International Conference on Dynamical Systems and Control. Rezoning Techniques for ALE Computations. 2008. Diaz A..
    27. Nonlinear Analysis: Hybrid Systems. An Error Analysis for Execution Traces of Hybrid Automata Using Jacobi's Equation. 2008; 2(1). Diaz, A.
    28. European Series in Applied and Industrial Mathematics: Proceedings Societe de Mathematiques Appliquees et Industrielles. A Cell-Centered Arbitrary Lagrangian Eulerian (ALE) Method for Multimaterial Compressible Flows. 2008; 13. Maire P-H, De Buhan M, Diaz A, Dobrzynski C, Kluth G, Lagoutiere, F.
    29. International Journal of Hybrid Systems. Extraction of Finite State Controllers, AD and DA maps, and Associated Small Topologies for Measure Valued Control Laws. 2003. Diaz A..
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