Carolyn Larabell, PhD

SchoolUCSF School of Medicine
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
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    Collapse Research 
    Collapse research activities and funding
    Devising New Technologies for Live Imaging of Epigenetic Processes
    NIH/NIDA R01DA030320Sep 15, 2010 - May 31, 2015
    Role: Co-Principal Investigator
    Resource for X-Ray Tomography of Whole Cells
    NIH/NIGMS P41GM103445May 6, 2004 - Apr 30, 2020
    Role: Principal Investigator
    Resource for X-ray Tomography of Whole Cells
    NIH/NCRR P41RR019664May 6, 2004 - Apr 30, 2013
    Role: Principal Investigator
    3-D Localization of Molecules Using X-Ray Tomography
    NIH/NIGMS R01GM070445Mar 1, 2004 - Feb 28, 2010
    Role: Principal Investigator
    3-D Cryo X-ray Microscopy of Whole Cells
    NIH/NIGMS R01GM063948Aug 1, 2001 - Jul 31, 2007
    Role: Principal Investigator
    NIH/NICHD R13HD039636Aug 7, 2000 - Jul 31, 2001
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hammel M, Amlanjyoti D, Reyes FE, Chen JH, Parpana R, Tang HY, Larabell CA, Tainer JA, Adhya S. HU multimerization shift controls nucleoid compaction. Sci Adv. 2016 Jul; 2(7):e1600650. PMID: 27482541.
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    2. Myllys M, Ruokolainen V, Aho V, Smith EA, Hakanen S, Peri P, Salvetti A, Timonen J, Hukkanen V, Larabell CA, Vihinen-Ranta M. Herpes simplex virus 1 induces egress channels through marginalized host chromatin. Sci Rep. 2016; 6:28844. PMID: 27349677.
      View in: PubMed
    3. Tjong H, Li W, Kalhor R, Dai C, Hao S, Gong K, Zhou Y, Li H, Zhou XJ, Le Gros MA, Larabell CA, Chen L, Alber F. Population-based 3D genome structure analysis reveals driving forces in spatial genome organization. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):E1663-72. PMID: 26951677.
      View in: PubMed
    4. Ugarte F, Sousae R, Cinquin B, Martin EW, Krietsch J, Sanchez G, Inman M, Tsang H, Warr M, Passegué E, Larabell CA, Forsberg EC. Progressive Chromatin Condensation and H3K9 Methylation Regulate the Differentiation of Embryonic and Hematopoietic Stem Cells. Stem Cell Reports. 2015 Nov 10; 5(5):728-40. PMID: 26489895.
      View in: PubMed
    5. Elgass KD, Smith EA, LeGros MA, Larabell CA, Ryan MT. Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells. J Cell Sci. 2015 Aug 1; 128(15):2795-804. PMID: 26101352; PMCID: PMC4540952 [Available on 08/01/16].
    6. Do M, Isaacson SA, McDermott G, Le Gros MA, Larabell CA. Imaging and characterizing cells using tomography. Arch Biochem Biophys. 2015 Sep 1; 581:111-21. PMID: 25602704; PMCID: PMC4506273 [Available on 09/01/16].
    7. Walters AD, May CK, Dauster ES, Cinquin BP, Smith EA, Robellet X, D'Amours D, Larabell CA, Cohen-Fix O. The yeast polo kinase Cdc5 regulates the shape of the mitotic nucleus. Curr Biol. 2014 Dec 1; 24(23):2861-7. PMID: 25454593; PMCID: PMC4255140 [Available on 12/01/15].
    8. Smith EA, McDermott G, Do M, Leung K, Panning B, Le Gros MA, Larabell CA. Quantitatively imaging chromosomes by correlated cryo-fluorescence and soft x-ray tomographies. Biophys J. 2014 Oct 21; 107(8):1988-96. PMID: 25418180; PMCID: PMC4213715.
    9. Patwardhan A, Ashton A, Brandt R, Butcher S, Carzaniga R, Chiu W, Collinson L, Doux P, Duke E, Ellisman MH, Franken E, Grünewald K, Heriche JK, Koster A, Kühlbrandt W, Lagerstedt I, Larabell C, Lawson CL, Saibil HR, Sanz-García E, Subramaniam S, Verkade P, Swedlow JR, Kleywegt GJ. A 3D cellular context for the macromolecular world. Nat Struct Mol Biol. 2014 Oct; 21(10):841-5. PMID: 25289590; PMCID: PMC4346196.
    10. Le Gros MA, McDermott G, Cinquin BP, Smith EA, Do M, Chao WL, Naulleau PP, Larabell CA. Biological soft X-ray tomography on beamline 2.1 at the Advanced Light Source. J Synchrotron Radiat. 2014 Nov; 21(Pt 6):1370-7. PMID: 25343808; PMCID: PMC4211134.
    11. Cinquin BP, Do M, McDermott G, Walters AD, Myllys M, Smith EA, Cohen-Fix O, Le Gros MA, Larabell CA. Putting molecules in their place. J Cell Biochem. 2014 Feb; 115(2):209-16. PMID: 23966233; PMCID: PMC3865101.
    12. Smith EA, Cinquin BP, Do M, McDermott G, Le Gros MA, Larabell CA. Correlative cryogenic tomography of cells using light and soft x-rays. Ultramicroscopy. 2014 Aug; 143:33-40. PMID: 24355261; PMCID: PMC4013260.
    13. Isaacson SA, Larabell CA, Le Gros MA, McQueen DM, Peskin CS. The influence of spatial variation in chromatin density determined by X-ray tomograms on the time to find DNA binding sites. Bull Math Biol. 2013 Nov; 75(11):2093-117. PMID: 23955281; PMCID: PMC3934756.
    14. Smith EA, Cinquin BP, McDermott G, Le Gros MA, Parkinson DY, Kim HT, Larabell CA. Correlative microscopy methods that maximize specimen fidelity and data completeness, and improve molecular localization capabilities. J Struct Biol. 2013 Oct; 184(1):12-20. PMID: 23531637; PMCID: PMC3758393.
    15. Parkinson DY, Epperly LR, McDermott G, Le Gros MA, Boudreau RM, Larabell CA. Nanoimaging cells using soft X-ray tomography. Methods Mol Biol. 2013; 950:457-81. PMID: 23086890.
      View in: PubMed
    16. Clowney EJ, LeGros MA, Mosley CP, Clowney FG, Markenskoff-Papadimitriou EC, Myllys M, Barnea G, Larabell CA, Lomvardas S. Nuclear aggregation of olfactory receptor genes governs their monogenic expression. Cell. 2012 Nov 9; 151(4):724-37. PMID: 23141535; PMCID: PMC3659163.
    17. McDermott G, Fox DM, Epperly L, Wetzler M, Barron AE, Le Gros MA, Larabell CA. Visualizing and quantifying cell phenotype using soft X-ray tomography. Bioessays. 2012 Apr; 34(4):320-7. PMID: 22290620; PMCID: PMC3343367.
    18. McDermott G, Le Gros MA, Larabell CA. Visualizing cell architecture and molecular location using soft x-ray tomography and correlated cryo-light microscopy. Annu Rev Phys Chem. 2012; 63:225-39. PMID: 22242730; PMCID: PMC3349341.
    19. Parkinson DY, Knoechel C, Yang C, Larabell CA, Le Gros MA. Automatic alignment and reconstruction of images for soft X-ray tomography. J Struct Biol. 2012 Feb; 177(2):259-66. PMID: 22155289; PMCID: PMC3288662.
    20. Hanssen E, Knoechel C, Dearnley M, Dixon MW, Le Gros M, Larabell C, Tilley L. Soft X-ray microscopy analysis of cell volume and hemoglobin content in erythrocytes infected with asexual and sexual stages of Plasmodium falciparum. J Struct Biol. 2012 Feb; 177(2):224-32. PMID: 21945653; PMCID: PMC3349340.
    21. Uchida M, Sun Y, McDermott G, Knoechel C, Le Gros MA, Parkinson D, Drubin DG, Larabell CA. Quantitative analysis of yeast internal architecture using soft X-ray tomography. Yeast. 2011 Mar; 28(3):227-36. PMID: 21360734; PMCID: PMC3404734.
    22. Larabell CA, Nugent KA. Imaging cellular architecture with X-rays. Curr Opin Struct Biol. 2010 Oct; 20(5):623-31. PMID: 20869868; PMCID: PMC3268817.
    23. Hanssen E, Knoechel C, Klonis N, Abu-Bakar N, Deed S, LeGros M, Larabell C, Tilley L. Cryo transmission X-ray imaging of the malaria parasite, P. falciparum. J Struct Biol. 2011 Jan; 173(1):161-8. PMID: 20826218; PMCID: PMC3005799.
    24. Uchida M, McDermott G, Wetzler M, Le Gros MA, Myllys M, Knoechel C, Barron AE, Larabell CA. Soft X-ray tomography of phenotypic switching and the cellular response to antifungal peptoids in Candida albicans. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19375-80. PMID: 19880740; PMCID: PMC2780763.
    25. McDermott G, Le Gros MA, Knoechel CG, Uchida M, Larabell CA. Soft X-ray tomography and cryogenic light microscopy: the cool combination in cellular imaging. Trends Cell Biol. 2009 Nov; 19(11):587-95. PMID: 19818625; PMCID: PMC3276488.
    26. Le Gros MA, McDermott G, Uchida M, Knoechel CG, Larabell CA. High-aperture cryogenic light microscopy. J Microsc. 2009 Jul; 235(1):1-8. PMID: 19566622; PMCID: PMC3350647.
    27. Ashcroft JM, Gu W, Zhang T, Hughes SM, Hartman KB, Hofmann C, Kanaras AG, Kilcoyne DA, Le Gros M, Yin Y, Alivisatos AP, Larabell CA. TiO2 nanoparticles as a soft X-ray molecular probe. Chem Commun (Camb). 2008 Jun 7; (21):2471-3. PMID: 18491018; PMCID: PMC3355471.
    28. Parkinson DY, McDermott G, Etkin LD, Le Gros MA, Larabell CA. Quantitative 3-D imaging of eukaryotic cells using soft X-ray tomography. J Struct Biol. 2008 Jun; 162(3):380-6. PMID: 18387313; PMCID: PMC2505111.
    29. Traverso EE, Cho MS, Wu CF, Sater AK, Larabell CA, Kloc M, Etkin LD. Disruption of the dynamic sub-cellular localization of the Xenopus tumorhead protein causes embryonic lethality at the early gastrula transition. Differentiation. 2007 Dec; 75(10):947-56. PMID: 17459085.
      View in: PubMed
    30. Gu W, Etkin LD, Le Gros MA, Larabell CA. X-ray tomography of Schizosaccharomyces pombe. Differentiation. 2007 Jul; 75(6):529-35. PMID: 17459084.
      View in: PubMed
    31. Chan AP, Kloc M, Larabell CA, LeGros M, Etkin LD. The maternally localized RNA fatvg is required for cortical rotation and germ cell formation. Mech Dev. 2007 May; 124(5):350-63. PMID: 17376659; PMCID: PMC2435194.
    32. Tang YJ, Ashcroft JM, Chen D, Min G, Kim CH, Murkhejee B, Larabell C, Keasling JD, Chen FF. Charge-associated effects of fullerene derivatives on microbial structural integrity and central metabolism. Nano Lett. 2007 Mar; 7(3):754-60. PMID: 17288489.
      View in: PubMed
    33. Fu A, Gu W, Boussert B, Koski K, Gerion D, Manna L, Le Gros M, Larabell CA, Alivisatos AP. Semiconductor quantum rods as single molecule fluorescent biological labels. Nano Lett. 2007 Jan; 7(1):179-82. PMID: 17212460; PMCID: PMC3984543.
    34. Gu W, Pellegrino T, Parak WJ, Boudreau R, Le Gros MA, Alivisatos AP, Larabell CA. Measuring cell motility using quantum dot probes. Methods Mol Biol. 2007; 374:125-31. PMID: 17237535.
      View in: PubMed
    35. Fu A, Gu W, Larabell C, Alivisatos AP. Semiconductor nanocrystals for biological imaging. Curr Opin Neurobiol. 2005 Oct; 15(5):568-75. PMID: 16150591.
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    36. Le Gros MA, McDermott G, Larabell CA. X-ray tomography of whole cells. Curr Opin Struct Biol. 2005 Oct; 15(5):593-600. PMID: 16153818.
      View in: PubMed
    37. Gu W, Pellegrino T, Parak WJ, Boudreau R, Le Gros MA, Gerion D, Alivisatos AP, Larabell CA. Quantum-dot-based cell motility assay. Sci STKE. 2005 Jun 28; 2005(290):pl5. PMID: 15985641.
      View in: PubMed
    38. Alivisatos AP, Gu W, Larabell C. Quantum dots as cellular probes. Annu Rev Biomed Eng. 2005; 7:55-76. PMID: 16004566.
      View in: PubMed
    39. Larabell CA, Rowning BA, Moon RT. A PKC wave follows the calcium wave after activation of Xenopus eggs. Differentiation. 2004 Feb; 72(1):41-7. PMID: 15008825.
      View in: PubMed
    40. Larabell CA, Le Gros MA. X-ray tomography generates 3-D reconstructions of the yeast, saccharomyces cerevisiae, at 60-nm resolution. Mol Biol Cell. 2004 Mar; 15(3):957-62. PMID: 14699066; PMCID: PMC363052.
    41. Pellegrino T, Parak WJ, Boudreau R, Le Gros MA, Gerion D, Alivisatos AP, Larabell CA. Quantum dot-based cell motility assay. Differentiation. 2003 Dec; 71(9-10):542-8. PMID: 14686951.
      View in: PubMed
    42. Weaver C, Farr GH, Pan W, Rowning BA, Wang J, Mao J, Wu D, Li L, Larabell CA, Kimelman D. GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs. Development. 2003 Nov; 130(22):5425-36. PMID: 14507779.
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    43. Johnson N, Krebs M, Boudreau R, Giorgi G, LeGros M, Larabell C. Actin-filled nuclear invaginations indicate degree of cell de-differentiation. Differentiation. 2003 Sep; 71(7):414-24. PMID: 12969334.
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    44. Miao J, Hodgson KO, Ishikawa T, Larabell CA, LeGros MA, Nishino Y. Imaging whole Escherichia coli bacteria by using single-particle x-ray diffraction. Proc Natl Acad Sci U S A. 2003 Jan 7; 100(1):110-2. PMID: 12518059; PMCID: PMC140897.
    45. Ziegelbauer J, Shan B, Yager D, Larabell C, Hoffmann B, Tjian R. Transcription factor MIZ-1 is regulated via microtubule association. Mol Cell. 2001 Aug; 8(2):339-49. PMID: 11545736.
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    46. Meyer-Ilse W, Hamamoto D, Nair A, Lelièvre SA, Denbeaux G, Johnson L, Pearson AL, Yager D, Legros MA, Larabell CA. High resolution protein localization using soft X-ray microscopy. J Microsc. 2001 Mar; 201(Pt 3):395-403. PMID: 11240856.
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    47. Nakamura H, Wu C, Kuang J, Larabell C, Etkin LD. XCS-1, a maternally expressed gene product involved in regulating mitosis in Xenopus. J Cell Sci. 2000 Jul; 113 ( Pt 13):2497-505. PMID: 10852828.
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    48. Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J Cell Biol. 2000 Feb 7; 148(3):519-30. PMID: 10662777; PMCID: PMC2174808.
    49. Larabell CA. Confocal microscopy of live Xenopus oocytes, eggs, and embryos. Methods Mol Biol. 2000; 135:175-82. PMID: 10791314.
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    50. Miller JR, Rowning BA, Larabell CA, Yang-Snyder JA, Bates RL, Moon RT. Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation. J Cell Biol. 1999 Jul 26; 146(2):427-37. PMID: 10427095; PMCID: PMC2156185.
    51. Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A. 1998 Dec 8; 95(25):14821-6. PMID: 9843973; PMCID: PMC24533.
    52. Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc Natl Acad Sci U S A. 1998 Dec 8; 95(25):14711-6. PMID: 9843954; PMCID: PMC24514.
    53. Kloc M, Larabell C, Chan AP, Etkin LD. Contribution of METRO pathway localized molecules to the organization of the germ cell lineage. Mech Dev. 1998 Jul; 75(1-2):81-93. PMID: 9739112.
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    54. Krauss SW, Larabell CA, Lockett S, Gascard P, Penman S, Mohandas N, Chasis JA. Structural protein 4.1 in the nucleus of human cells: dynamic rearrangements during cell division. J Cell Biol. 1997 Apr 21; 137(2):275-89. PMID: 9128242; PMCID: PMC2139783.
    55. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 1997 Apr 7; 137(1):231-45. PMID: 9105051; PMCID: PMC2139858.
    56. Larabell CA, Torres M, Rowning BA, Yost C, Miller JR, Wu M, Kimelman D, Moon RT. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J Cell Biol. 1997 Mar 10; 136(5):1123-36. PMID: 9060476; PMCID: PMC2132470.
    57. Rowning BA, Wells J, Wu M, Gerhart JC, Moon RT, Larabell CA. Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1224-9. PMID: 9037034; PMCID: PMC19772.
    58. Kloc M, Larabell C, Etkin LD. Elaboration of the messenger transport organizer pathway for localization of RNA to the vegetal cortex of Xenopus oocytes. Dev Biol. 1996 Nov 25; 180(1):119-30. PMID: 8948579.
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    59. Larabell CA, Rowning BA, Wells J, Wu M, Gerhart JC. Confocal microscopy analysis of living Xenopus eggs and the mechanism of cortical rotation. Development. 1996 Apr; 122(4):1281-9. PMID: 8620855.
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    60. Larabell CA. Cortical cytoskeleton of the Xenopus oocyte, egg, and early embryo. Curr Top Dev Biol. 1995; 31:433-53. PMID: 8746672.
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    61. Gallicano GI, Larabell CA, McGaughey RW, Capco DG. Novel cytoskeletal elements in mammalian eggs are composed of a unique arrangement of intermediate filaments. Mech Dev. 1994 Mar; 45(3):211-26. PMID: 8011554.
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    62. Larabell CA, Fukuyama K, Epstein WL. Desmosome differentiation during epidermal cornification: new observations obtained from intermediate voltage electron microscopy. J Invest Dermatol. 1993 Jul; 101(1):103-4. PMID: 8331292.
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    63. Bonnell BS, Larabell C, Chandler DE. The sea urchin egg jelly coat is a three-dimensional fibrous network as seen by intermediate voltage electron microscopy and deep etching analysis. Mol Reprod Dev. 1993 Jun; 35(2):181-8. PMID: 8318223.
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    64. Larabell CA. A new technique for isolation and visualization of the Xenopus egg cortex reveals a complex cytoskeleton. J Struct Biol. 1993 Mar-Apr; 110(2):154-9. PMID: 8338718.
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    65. Capco DG, Gallicano GI, McGaughey RW, Downing KH, Larabell CA. Cytoskeletal sheets of mammalian eggs and embryos: a lattice-like network of intermediate filaments. Cell Motil Cytoskeleton. 1993; 24(2):85-99. PMID: 8440027.
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    66. Lindsay LL, Larabell C, Hedrick JL. Localization of a chymotrypsin-like protease to the perivitelline space of Xenopus laevis eggs. Dev Biol. 1992 Dec; 154(2):433-6. PMID: 1426648.
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    67. Larabell C, Nuccitelli R. Inositol lipid hydrolysis contributes to the Ca2+ wave in the activating egg of Xenopus laevis. Dev Biol. 1992 Oct; 153(2):347-55. PMID: 1327924.
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    68. Smith NR, Benson S, Larabell C. An in-vitro extracellular matrix model system to visualize whole cells with intermediate voltage electron microscopy (IVEM). J Electron Microsc Tech. 1991 Nov; 19(3):380-1. PMID: 1795190.
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    69. Larabell C, Chandler DE. Fertilization-induced changes in the vitelline envelope of echinoderm and amphibian eggs: self-assembly of an extracellular matrix. J Electron Microsc Tech. 1991 Mar; 17(3):294-318. PMID: 2045963.
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    70. Dersch MA, Bement WM, Larabell C, Mecca MD, Capco DG. Cortical membrane-trafficking during the meiotic resumption of Xenopus laevis oocytes. Cell Tissue Res. 1991 Feb; 263(2):375-83. PMID: 2007258.
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    71. Larabell C, Chandler DE. Stepwise transformation of the vitelline envelope of Xenopus eggs at activation: a quick-freeze, deep-etch analysis. Dev Biol. 1990 Jun; 139(2):263-8. PMID: 2338169.
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    72. Larabell C, Chandler DE. Quick-freeze, deep-etch, rotary-shadow views of the extracellular matrix and cortical cytoskeleton of Xenopus laevis eggs. J Electron Microsc Tech. 1989 Nov; 13(3):228-43. PMID: 2585120.
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    73. Racowsky C, Baldwin KV, Larabell C, DeMarais AA, Kazilek CJ. Down-regulation of membrana granulosa cell gap junctions is correlated with irreversible commitment to resume meiosis in golden Syrian hamster oocytes. Eur J Cell Biol. 1989 Aug; 49(2):244-51. PMID: 2776774.
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    74. Larabell C, Chandler DE. The coelomic envelope of Xenopus laevis eggs: a quick-freeze, deep-etch analysis. Dev Biol. 1989 Jan; 131(1):126-35. PMID: 2909400.
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    75. Larabell C, Chandler DE. In vitro formation of the "S" layer, a unique component of the fertilization envelope in Xenopus laevis eggs. Dev Biol. 1988 Nov; 130(1):356-64. PMID: 3181634.
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    76. Larabell CA, Chandler DE. The extracellular matrix of Xenopus laevis eggs: a quick-freeze, deep-etch analysis of its modification at fertilization. J Cell Biol. 1988 Aug; 107(2):731-41. PMID: 3417770; PMCID: PMC2115231.
    77. Larabell CA, Chandler DE. Freeze-fracture analysis of structural reorganization during meiotic maturation in oocytes of Xenopus laevis. Cell Tissue Res. 1988 Jan; 251(1):129-36. PMID: 3342433.
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