Daniele Canzio * UCSF Profiles

Daniele Canzio, PhD

Title(s)	Asst Professor in Residence, Neurology
School	School of Medicine
Phone	415-514-2240
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Biography

Education and Training

Columbia University , New York		12/2018	Molecular Biology/Neuroscience
University of California, San Francisco, San Francisco	PhD	12/2012	Chemical Biology
University of California, Santa Barbara, Santa Barbara	BS	03/2006	Chemistry/Biochemistry

Awards and Honors

Columbia University

2014 -

2017

Helen Hay Whitney Postdoctoral Research Fellowship

Overview

My laboratory is interested in understanding the molecular mechanism regulating the generation of cell-surface neural identities by Clustered Protocadherin genes. This process is of fundamental importance to the assembly of neural circuits in the mammalian brain.

ORNG Applications

Websites

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T. Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin a Promoter Choice. Cell. 2019 Mar 30. PMID: 30955885.

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Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T. Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly. Annu Rev Cell Dev Biol. 2018 10 06; 34:471-493. PMID: 30296392.

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Duffy EE, Canzio D, Maniatis T, Simon MD. Solid phase chemistry to covalently and reversibly capture thiolated RNA. Nucleic Acids Res. 2018 Aug 21; 46(14):6996-7005. PMID: 29986098.

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Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, Ren B, Krainer AR, Maniatis T, Wu Q. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 2015 Aug 13; 162(4):900-10. PMID: 26276636; PMCID: PMC4642453.

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Canzio D, Larson A, Narlikar GJ. Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol. 2014 Jun; 24(6):377-86. PMID: 24618358; PMCID: PMC4077871.

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Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. PMID: 23485968; PMCID: PMC3907283.

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Armache KJ, Garlick JD, Canzio D, Narlikar GJ, Kingston RE. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science. 2011 Nov 18; 334(6058):977-82. PMID: 22096199; PMCID: PMC4098850.

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Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 07; 41(1):67-81. PMID: 21211724; PMCID: PMC3752404.

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Park M, Canzio D, Bruice TC. Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents. Bioorg Med Chem Lett. 2008 Apr 01; 18(7):2377-84. PMID: 18353646.

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Correa BJ, Canzio D, Kahane AL, Reddy PM, Bruice TC. DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides. Bioorg Med Chem Lett. 2006 Jul 15; 16(14):3745-50. PMID: 16682192.

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