Daniele Canzio, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address1651 4th Street, #481G
San Francisco CA 94158
Phone415-514-2240
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse education and training
    Columbia University , New York12/2018Molecular Biology/Neuroscience
    University of California, San Francisco, San FranciscoPhD12/2012Chemical Biology
    University of California, Santa Barbara, Santa BarbaraBS03/2006Chemistry/Biochemistry
    Collapse awards and honors
    UCSF2022Chan Zuckerberg Biohub Investigator Award
    UCSF2021NIH Director New Innovator Award (DP2)
    Columbia University 2014  - 2017Helen Hay Whitney Postdoctoral Research Fellowship

    Collapse Overview 
    Collapse overview
    My laboratory is interested in understanding the molecular mechanism regulating the generation of cell-surface neural identities by Clustered Protocadherin genes. This process is of fundamental importance to the assembly of neural circuits in the mammalian brain.

    Collapse Research 
    Collapse research activities and funding
    How do neurons recognize self from non-self?
    NIH DP2MH129955Sep 1, 2021 - Aug 31, 2024
    Role: Principal Investigator
    Coupling promoter choice and alternative RNA splicing in the mammalian Protocadherin gene cluster
    NIH R00GM121815Jun 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Coupling promoter choice and alternative RNA splicing in the mammalian Protocadherin gene cluster
    NIH K99GM121815Jun 1, 2017 - May 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tuning cohesin trajectories enables differential readout of the Pcdhα cluster across neurons. Science. 2024 07 26; 385(6707):eadm9802. Kiefer L, Gaudin S, Rajkumar SM, Servito GIF, Langen J, Mui MH, Nawsheen S, Canzio D. PMID: 39052779.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    2. WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring. Science. 2023 06 23; 380(6651):eadf8440. Kiefer L, Chiosso A, Langen J, Buckley A, Gaudin S, Rajkumar SM, Servito GIF, Cha ES, Vijay A, Yeung A, Horta A, Mui MH, Canzio D. PMID: 37347873.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    3. STL-seq reveals pause-release and termination kinetics for promoter-proximal paused RNA polymerase II transcripts. Mol Cell. 2021 11 04; 81(21):4398-4412.e7. Zimmer JT, Rosa-Mercado NA, Canzio D, Steitz JA, Simon MD. PMID: 34520723; PMCID: PMC9020433.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    4. The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice. Neuron. 2020 06 03; 106(5):789-805.e5. Gerbino V, Kaunga E, Ye J, Canzio D, O'Keeffe S, Rudnick ND, Guarnieri P, Lutz CM, Maniatis T. PMID: 32220666.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    5. The generation of a protocadherin cell-surface recognition code for neural circuit assembly. Curr Opin Neurobiol. 2019 12; 59:213-220. Canzio D, Maniatis T. PMID: 31710891; PMCID: PMC6888844.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    6. Clustered protocadherins methylation alterations in cancer. Clin Epigenetics. 2019 07 09; 11(1):100. Vega-Benedetti AF, Loi E, Moi L, Blois S, Fadda A, Antonelli M, Arcella A, Badiali M, Giangaspero F, Morra I, Columbano A, Restivo A, Zorcolo L, Gismondi V, Varesco L, Bellomo SE, Giordano S, Canale M, Casadei-Gardini A, Faloppi L, Puzzoni M, Scartozzi M, Ziranu P, Cabras G, Cocco P, Ennas MG, Satta G, Zucca M, Canzio D, Zavattari P. PMID: 31288858; PMCID: PMC6617643.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    7. Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin α Promoter Choice. Cell. 2019 04 18; 177(3):639-653.e15. Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T. PMID: 30955885; PMCID: PMC6823843.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    8. Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly. Annu Rev Cell Dev Biol. 2018 10 06; 34:471-493. Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T. PMID: 30296392.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    9. Solid phase chemistry to covalently and reversibly capture thiolated RNA. Nucleic Acids Res. 2018 08 21; 46(14):6996-7005. Duffy EE, Canzio D, Maniatis T, Simon MD. PMID: 29986098; PMCID: PMC6101502.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    10. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 2015 Aug 13; 162(4):900-10. Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, Ren B, Krainer AR, Maniatis T, Wu Q. PMID: 26276636; PMCID: PMC4642453.
      View in: PubMed   Mentions: 450     Fields:    Translation:HumansAnimalsCells
    11. Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol. 2014 Jun; 24(6):377-86. Canzio D, Larson A, Narlikar GJ. PMID: 24618358; PMCID: PMC4077871.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    12. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. PMID: 23485968; PMCID: PMC3907283.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    13. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science. 2011 Nov 18; 334(6058):977-82. Armache KJ, Garlick JD, Canzio D, Narlikar GJ, Kingston RE. PMID: 22096199; PMCID: PMC4098850.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    14. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 07; 41(1):67-81. Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. PMID: 21211724; PMCID: PMC3752404.
      View in: PubMed   Mentions: 162     Fields:    
    15. Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents. Bioorg Med Chem Lett. 2008 Apr 01; 18(7):2377-84. Park M, Canzio D, Bruice TC. PMID: 18353646.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides. Bioorg Med Chem Lett. 2006 Jul 15; 16(14):3745-50. Correa BJ, Canzio D, Kahane AL, Reddy PM, Bruice TC. PMID: 16682192.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
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