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Daniele Canzio, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Phone415-514-2240
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    Collapse Biography 
    Collapse Education and Training
    Columbia University , New York12/2018Molecular Biology/Neuroscience
    University of California, San Francisco, San FranciscoPhD12/2012Chemical Biology
    University of California, Santa Barbara, Santa BarbaraBS03/2006Chemistry/Biochemistry
    Collapse Awards and Honors
    Columbia University 2014  - 2017Helen Hay Whitney Postdoctoral Research Fellowship

    Collapse Overview 
    Collapse Overview
    My laboratory is interested in understanding the molecular mechanism regulating the generation of cell-surface neural identities by Clustered Protocadherin genes. This process is of fundamental importance to the assembly of neural circuits in the mammalian brain.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vega-Benedetti AF, Loi E, Moi L, Blois S, Fadda A, Antonelli M, Arcella A, Badiali M, Giangaspero F, Morra I, Columbano A, Restivo A, Zorcolo L, Gismondi V, Varesco L, Bellomo SE, Giordano S, Canale M, Casadei-Gardini A, Faloppi L, Puzzoni M, Scartozzi M, Ziranu P, Cabras G, Cocco P, Ennas MG, Satta G, Zucca M, Canzio D, Zavattari P. Clustered protocadherins methylation alterations in cancer. Clin Epigenetics. 2019 Jul 09; 11(1):100. PMID: 31288858.
      View in: PubMed
    2. Canzio D, Nwakeze CL, Horta A, Rajkumar SM, Coffey EL, Duffy EE, Duffié R, Monahan K, O'Keeffe S, Simon MD, Lomvardas S, Maniatis T. Antisense lncRNA Transcription Mediates DNA Demethylation to Drive Stochastic Protocadherin a Promoter Choice. Cell. 2019 Apr 18; 177(3):639-653.e15. PMID: 30955885.
      View in: PubMed
    3. Mountoufaris G, Canzio D, Nwakeze CL, Chen WV, Maniatis T. Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly. Annu Rev Cell Dev Biol. 2018 10 06; 34:471-493. PMID: 30296392.
      View in: PubMed
    4. Duffy EE, Canzio D, Maniatis T, Simon MD. Solid phase chemistry to covalently and reversibly capture thiolated RNA. Nucleic Acids Res. 2018 Aug 21; 46(14):6996-7005. PMID: 29986098.
      View in: PubMed
    5. Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, Ren B, Krainer AR, Maniatis T, Wu Q. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 2015 Aug 13; 162(4):900-10. PMID: 26276636.
      View in: PubMed
    6. Canzio D, Larson A, Narlikar GJ. Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol. 2014 Jun; 24(6):377-86. PMID: 24618358.
      View in: PubMed
    7. Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 2013 Apr 18; 496(7445):377-81. PMID: 23485968; PMCID: PMC3907283.
    8. Armache KJ, Garlick JD, Canzio D, Narlikar GJ, Kingston RE. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution. Science. 2011 Nov 18; 334(6058):977-82. PMID: 22096199.
      View in: PubMed
    9. Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B. Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell. 2011 Jan 07; 41(1):67-81. PMID: 21211724; PMCID: PMC3752404.
    10. Park M, Canzio D, Bruice TC. Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents. Bioorg Med Chem Lett. 2008 Apr 01; 18(7):2377-84. PMID: 18353646.
      View in: PubMed
    11. Correa BJ, Canzio D, Kahane AL, Reddy PM, Bruice TC. DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides. Bioorg Med Chem Lett. 2006 Jul 15; 16(14):3745-50. PMID: 16682192.
      View in: PubMed