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    Mazen Kheirbek, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address675 Nelson Rising Lane
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      Washington University in St. LouisBA
      University of ChicagoPhD
      Columbia UniversityPostdoc

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Carvalho Poyraz F, Holzner E, Bailey MR, Meszaros J, Kenney L, Kheirbek MA, Balsam PD, Kellendonk C. Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action. J Neurosci. 2016 Jun 1; 36(22):5988-6001. PMID: 27251620.
        View in: PubMed
      2. Tannenholz L, Hen R, Kheirbek MA. GluN2B-Containg NMDA Receptors on Adult-Born Granule Cells Contribute to the Antidepressant Action of Fluoxetine. Front Neurosci. 2016; 10:242. PMID: 27303260.
        View in: PubMed
      3. Danielson NB, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg AR, Drew LJ, Hen R, Losonczy A, Kheirbek MA. Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding. Neuron. 2016 Apr 6; 90(1):101-12. PMID: 26971949.
        View in: PubMed
      4. Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R. Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons. Hippocampus. 2016 Jun; 26(6):763-78. PMID: 26662922.
        View in: PubMed
      5. Borgkvist A, Avegno EM, Wong MY, Kheirbek MA, Sonders MS, Hen R, Sulzer D. Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice. Neuron. 2015 Sep 2; 87(5):976-88. PMID: 26335644; PMCID: PMC4559856 [Available on 09/02/16].
      6. Kheirbek MA. Finding the Roots of Adult Neurogenesis. Cell. 2015 Jun 18; 161(7):1500-2. PMID: 26091033.
        View in: PubMed
      7. Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell. 2015 Jan 15; 160(1-2):269-84. PMID: 25594183; PMCID: PMC4436082 [Available on 01/15/16].
      8. Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, Hen R. Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron. 2014 Jul 2; 83(1):189-201. PMID: 24991962; PMCID: PMC4169172.
      9. Kheirbek MA, Hen R. Add neurons, subtract anxiety. Sci Am. 2014 Jul; 311(1):62-7. PMID: 24974712; PMCID: PMC4165637.
      10. Tannenholz L, Jimenez JC, Kheirbek MA. Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. Front Behav Neurosci. 2014; 8:147. PMID: 24834033; PMCID: PMC4018538.
      11. Lovett-Barron M, Kaifosh P, Kheirbek MA, Danielson N, Zaremba JD, Reardon TR, Turi GF, Hen R, Zemelman BV, Losonczy A. Dendritic inhibition in the hippocampus supports fear learning. Science. 2014 Feb 21; 343(6173):857-63. PMID: 24558155; PMCID: PMC4018419.
      12. Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Simpson HB, Deisseroth K, Gordon JA, Hen R. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science. 2013 Jun 7; 340(6137):1234-9. PMID: 23744948; PMCID: PMC3954809.
      13. Kheirbek MA, Hen R. (Radio)active neurogenesis in the human hippocampus. Cell. 2013 Jun 6; 153(6):1183-4. PMID: 23746833; PMCID: PMC4046854.
      14. Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R. Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 2013 Mar 6; 77(5):955-68. PMID: 23473324; PMCID: PMC3595120.
      15. Kheirbek MA, Klemenhagen KC, Sahay A, Hen R. Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci. 2012 Dec; 15(12):1613-20. PMID: 23187693; PMCID: PMC3638121.
      16. Kheirbek MA, Tannenholz L, Hen R. NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination. J Neurosci. 2012 Jun 20; 32(25):8696-702. PMID: 22723709; PMCID: PMC3388607.
      17. Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature. 2011 Apr 28; 472(7344):466-70. PMID: 21460835; PMCID: PMC3084370.
      18. Kheirbek MA, Hen R. Dorsal vs ventral hippocampal neurogenesis: implications for cognition and mood. Neuropsychopharmacology. 2011 Jan; 36(1):373-4. PMID: 21116266; PMCID: PMC3055508.
      19. Beeler JA, Cao ZF, Kheirbek MA, Ding Y, Koranda J, Murakami M, Kang UJ, Zhuang X. Dopamine-dependent motor learning: insight into levodopa's long-duration response. Ann Neurol. 2010 May; 67(5):639-47. PMID: 20437561; PMCID: PMC3129617.
      20. Kheirbek MA, Beeler JA, Chi W, Ishikawa Y, Zhuang X. A molecular dissociation between cued and contextual appetitive learning. Learn Mem. 2010 Mar; 17(3):148-54. PMID: 20189959; PMCID: PMC2832921.
      21. Kheirbek MA, Britt JP, Beeler JA, Ishikawa Y, McGehee DS, Zhuang X. Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning. J Neurosci. 2009 Sep 30; 29(39):12115-24. PMID: 19793969; PMCID: PMC2782774.
      22. Kheirbek MA, Beeler JA, Ishikawa Y, Zhuang X. A cAMP pathway underlying reward prediction in associative learning. J Neurosci. 2008 Oct 29; 28(44):11401-8. PMID: 18971482; PMCID: PMC2610269.
      23. Beeler JA, Cao ZF, Kheirbek MA, Zhuang X. Loss of cocaine locomotor response in Pitx3-deficient mice lacking a nigrostriatal pathway. Neuropsychopharmacology. 2009 Apr; 34(5):1149-61. PMID: 18704092; PMCID: PMC2752723.
      24. Kheirbek MA. A molecular switch for induction of long-term depression of corticostriatal transmission. J Neurosci. 2007 Sep 12; 27(37):9824-5. PMID: 17855596.
        View in: PubMed
      25. Hale ME, Kheirbek MA, Schriefer JE, Prince VE. Hox gene misexpression and cell-specific lesions reveal functionality of homeotically transformed neurons. J Neurosci. 2004 Mar 24; 24(12):3070-6. PMID: 15044546.
        View in: PubMed
      26. McClintock JM, Kheirbek MA, Prince VE. Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention. Development. 2002 May; 129(10):2339-54. PMID: 11973267.
        View in: PubMed
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