Anna Victoria Molofsky | UCSF Profiles

Anna Victoria Molofsky, MD, PhD

Title(s)	Assistant Professor, Psychiatry
School	School of Medicine
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Biography

Education and Training

Amherst College	B.A.
University of Michigan	M.D.
University of Michigan	Ph.D
University of California-San Francisco	Adult Psychiatry Residency

Awards and Honors

	1997		Phi Beta Kappa
	2006		Harold M. Weintraub Graduate Student Award
	2015		Burroughs Wellcome Career Award for Medical Scientists
	2017		Pew Biomedical Scholar
	2017		NIH New Innovator Award

Research

Research Activities and Funding

Coordinate regulation of neural circuit remodeling by glia: a prospective molecular approach
NIH/NIMH DP2MH116507Sep 1, 2017 - May 31, 2022
Role: Principal Investigator

Region-restricted astrocytes in neural circuit formation and function
NIH/NIMH K08MH104417Jul 25, 2014 - Jun 30, 2018
Role: Principal Investigator

The role of the oncogene Bmi-1 in fibrobrain development
NIH/NINDS F30NS048642Mar 1, 2004 - Feb 28, 2007
Role: Principal Investigator

ORNG Applications

Websites

In The News

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Dorman LC, Molofsky AV. Demystifying Microglia: And Now the Work Begins. Immunity. 2019 Jan 15; 50(1):11-13. PMID: 30650371.

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Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham MC. Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. Nat Neurosci. 2018 Sep; 21(9):1171-1184. PMID: 30154505.

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Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018 Apr 18; 98(2):306-319.e7. PMID: 29606582.

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Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018 03 16; 359(6381):1269-1273. PMID: 29420261.

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Poskanzer KE, Molofsky AV. Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Annu Rev Physiol. 2018 Feb 10; 80:143-157. PMID: 29166242.

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Molofsky AV, Deneen B. Astrocyte development: A Guide for the Perplexed. Glia. 2015 Aug; 63(8):1320-9. PMID: 25963996.

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Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. PMID: 24776795.

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Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. PMID: 23840004; PMCID: PMC3909648.

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Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science. 2012 Jul 20; 337(6092):358-62. PMID: 22745251; PMCID: PMC4059181.

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Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development. 2012 Jul; 139(14):2477-87. PMID: 22675209; PMCID: PMC3383225.

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Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907. PMID: 22549954; PMCID: PMC3347787.

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He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ. Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol. 2009 Apr 15; 328(2):257-72. PMID: 19389366; PMCID: PMC2996717.

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Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006 Sep 28; 443(7110):448-52. PMID: 16957738; PMCID: PMC2586960.

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Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev. 2005 Jun 15; 19(12):1432-7. PMID: 15964994; PMCID: PMC1151659.

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Molofsky AV, Pardal R, Morrison SJ. Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol. 2004 Dec; 16(6):700-7. PMID: 15530784.

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Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003 Oct 30; 425(6961):962-7. PMID: 14574365; PMCID: PMC2614897.

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