Anna Victoria Molofsky, MD, PhD

Title(s)Associate Professor, Psychiatry
SchoolSchool of Medicine
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Amherst CollegeB.A.
    University of MichiganM.D.
    University of MichiganPh.D
    University of California-San FranciscoAdult Psychiatry Residency
    Collapse Awards and Honors
    1997Phi Beta Kappa
    2006Harold M. Weintraub Graduate Student Award
    2015Burroughs Wellcome Career Award for Medical Scientists
    2017 Pew Biomedical Scholar
    2017NIH New Innovator Award
    2019Freeman Prize for Basic Research- BBRF

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Microglial remodeling of the extracellular matrix in memory circuits
    NIH R01MH125000Dec 10, 2020 - Oct 31, 2025
    Role: Principal Investigator
    Astrocyte-microglial communication in developmental synapse formation
    NIH R01MH119349Feb 1, 2019 - Nov 30, 2023
    Role: Principal Investigator
    Coordinate regulation of neural circuit remodeling by glia: a prospective molecular approach
    NIH/NIMH DP2MH116507Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Investigating innate immune mechanisms of synapse remodeling by glia
    Pew Charitable Trusts 519807Aug 1, 2017 - Jul 31, 2021
    Role: Principal Investigator
    Astrocyte-Encoded Regional cues in Developmental Synapse Formation.
    Burroughs Wellcome Fund 1014757Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Publisher Correction: Circuit and molecular architecture of a ventral hippocampal network. Nat Neurosci. 2021 Nov; 24(11):1637. Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA. PMID: 34552273.
      View in: PubMed   Mentions:    Fields:    
    2. Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021 10 15; 10. Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI. PMID: 34652270; PMCID: PMC8639143.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    3. In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nat Commun. 2021 10 08; 12(1):5916. Silva NJ, Dorman LC, Vainchtein ID, Horneck NC, Molofsky AV. PMID: 34625548; PMCID: PMC8501082.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    4. A protective signal between the brain’s supporting cells in Alzheimer’s disease. Nature. 2021 Jul 14; 595(7869):651-652. Barron BJ, Molofsky MA. .
      View in: Publisher Site   Mentions:
    5. Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. ACS Sens. 2021 06 25; 6(6):2168-2180. Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW. PMID: 34102054; PMCID: PMC8240087.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    6. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. PMID: 33589835; PMCID: PMC8007081.
      View in: PubMed   Mentions: 704     Fields:    Translation:HumansAnimalsCells
    7. Astrocyte-immune cell interactions in physiology and pathology. Immunity. 2021 02 09; 54(2):211-224. Han RT, Kim RD, Molofsky AV, Liddelow SA. PMID: 33567261.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    8. Circuit and molecular architecture of a ventral hippocampal network. Nat Neurosci. 2020 11; 23(11):1444-1452. Gergues MM, Han KJ, Choi HS, Brown B, Clausing KJ, Turner VS, Vainchtein ID, Molofsky AV, Kheirbek MA. PMID: 32929245; PMCID: PMC7606799.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    9. Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity. Trends Immunol. 2020 09; 41(9):753-755. Rosenberg MF, Molofsky AV. PMID: 32800455; PMCID: PMC8214865.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell. 2020 07 23; 182(2):388-403.e15. Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV. PMID: 32615087; PMCID: PMC7497728.
      View in: PubMed   Mentions: 197     Fields:    Translation:AnimalsCells
    11. Astrocytes and Microglia: In Sickness and in Health. Trends Neurosci. 2020 03; 43(3):144-154. Vainchtein ID, Molofsky AV. PMID: 32044129; PMCID: PMC7472912.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansCells
    12. The immune system and psychiatric disease: a basic science perspective. Clin Exp Immunol. 2019 09; 197(3):294-307. Bennett FC, Molofsky AV. PMID: 31125426; PMCID: PMC6693968.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    13. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 03 19; 50(3):707-722.e6. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. PMID: 30824323; PMCID: PMC6553479.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    14. Demystifying Microglia: And Now the Work Begins. Immunity. 2019 01 15; 50(1):11-13. Dorman LC, Molofsky AV. PMID: 30650371.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    15. Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes. Nat Neurosci. 2018 09; 21(9):1171-1184. Kelley KW, Nakao-Inoue H, Molofsky AV, Oldham MC. PMID: 30154505; PMCID: PMC6192711.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    16. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018 04 18; 98(2):306-319.e7. Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. PMID: 29606582; PMCID: PMC5919779.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    17. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018 03 16; 359(6381):1269-1273. Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV. PMID: 29420261; PMCID: PMC6070131.
      View in: PubMed   Mentions: 253     Fields:    Translation:AnimalsCells
    18. Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Annu Rev Physiol. 2018 02 10; 80:143-157. Poskanzer KE, Molofsky AV. PMID: 29166242; PMCID: PMC5811396.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    19. Astrocyte development: A Guide for the Perplexed. Glia. 2015 Aug; 63(8):1320-9. Molofsky AV, Deneen B. PMID: 25963996.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    20. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. PMID: 24776795; PMCID: PMC4057936.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    21. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. PMID: 23840004; PMCID: PMC3909648.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    22. Chapter 36 Mechanisms of Astrocyte Development. Patterning and Cell Type Specification in the Developing CNS and PNS. 2013 Jan 1; 723-742. Molofsky MA, Molofsky MA, Hochstim HC, Deneen DB, Rowitch RD. .
      View in: Publisher Site   Mentions:
    23. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science. 2012 Jul 20; 337(6092):358-62. Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH. PMID: 22745251; PMCID: PMC4059181.
      View in: PubMed   Mentions: 285     Fields:    Translation:AnimalsCells
    24. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development. 2012 Jul; 139(14):2477-87. Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. PMID: 22675209; PMCID: PMC3383225.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    25. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907. Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. PMID: 22549954; PMCID: PMC3347787.
      View in: PubMed   Mentions: 360     Fields:    Translation:HumansCells
    26. Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol. 2009 Apr 15; 328(2):257-72. He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ. PMID: 19389366; PMCID: PMC2996717.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    27. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006 Sep 28; 443(7110):448-52. Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. PMID: 16957738; PMCID: PMC2586960.
      View in: PubMed   Mentions: 478     Fields:    Translation:AnimalsCells
    28. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev. 2005 Jun 15; 19(12):1432-7. Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R. PMID: 15964994; PMCID: PMC1151659.
      View in: PubMed   Mentions: 275     Fields:    Translation:AnimalsCells
    29. Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors. Cold Spring Harb Symp Quant Biol. 2005; 70:177-85. Pardal R, Molofsky AV, He S, Morrison SJ. PMID: 16869752.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    30. Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol. 2004 Dec; 16(6):700-7. Molofsky AV, Pardal R, Morrison SJ. PMID: 15530784.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    31. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003 Oct 30; 425(6961):962-7. Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ. PMID: 14574365; PMCID: PMC2614897.
      View in: PubMed   Mentions: 560     Fields:    Translation:AnimalsCells
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