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Ari Molofsky, MD, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentLaboratory Medicine
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    Collapse Biography 
    Collapse Awards and Honors
    UCSF2017ICIS Milstein Young Investigator Award
    UCSF2017AAI Young Investigator Travel Award
    UCSF2016  - 2019Larry L. Hillblom Foundation Young Investigator Award
    UCSF2009  - 2012Molecular Medicine Research Fellowship
    U. of Michigan2007MD graduate with research distinction
    U of Michigan2006Alpha Omega Alpha Medical Honors Society
    U. of Michigan2006Ward J. MacNeal Distinguished Dissertation
    U. of Michigan2004  - 2005Frederick G. Novy Fellowship
    U. of Texas1999Dean's Honored Graduate in Molecular Biology
    U. of Texas1995  - 1999National Merit Finalist Scholarship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Ghosts in the machine: Lymphocytes in the developing brain
    UCSF Quantitative Biosciences Institute Bold and Basic Research Grant Jul 1, 2017 - Jun 30, 2018
    Role: Faculty Mentor
    Exploring innate lymphocytes at the brain-immune interface
    Program for Breakthrough Biomedical Research: New Frontier Research Jun 15, 2017 - Jun 14, 2018
    Role: Co-Principal Investigator
    Adipose Tissue type 2 immunity in metabolic health and disease
    Larry L. Hillblom Foundation Startup Grant Aug 2, 2016 - Jul 21, 2019
    Role: Principal Investigator
    Regulation and function of allergic immune cells in visceral adipose tissue
    NIH/NIDDK K08DK101604May 1, 2014 - Feb 28, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky A, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Dec; 17(12):1381-1387. PMID: 27749840.
      View in: PubMed
    2. Cautivo KM, Molofsky A. Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells. Eur J Immunol. 2016 Jun; 46(6):1315-25. PMID: 27120716.
      View in: PubMed
    3. Molofsky A, Savage AK, Locksley RM. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity. 2015 Jun 16; 42(6):1005-19. PMID: 26084021; PMCID: PMC4471869.
    4. Molofsky A, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. Interleukin-33 and Interferon-? Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015 Jul 21; 43(1):161-74. PMID: 26092469; PMCID: PMC4512852.
    5. Guigas B, Molofsky A. A worm of one's own: how helminths modulate host adipose tissue function and metabolism. Trends Parasitol. 2015 Sep; 31(9):435-41. PMID: 25991556; PMCID: PMC4567404.
    6. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky A, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 2015 Jan 15; 160(1-2):74-87. PMID: 25543153; PMCID: PMC4297518.
    7. Van Gool F, Molofsky A, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 04; 124(24):3572-6. PMID: 25323825; PMCID: PMC4256909.
    8. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky A, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and ?d T cells. Immunity. 2014 Mar 20; 40(3):414-24. PMID: 24631157; PMCID: PMC4019510.
    9. Dawson, A.L., LeBoit, P.E., Molofsky, A.B., Ai, W.Z., and Pincus, L.B. Peripheral T-Cell Lymphoma, Not Otherwise Specified Presenting as Erythroderma. Pathology Case Reviews. 2014; (19):221-226.
    10. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky A, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. PMID: 24037376; PMCID: PMC3795960.
    11. Molofsky A, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49. PMID: 23420878; PMCID: PMC3600903.
    12. Rollins MD, Molofsky A, Nambiar A, Pandey S, Weiskopf RB, Toy P. Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Crit Care Med. 2012 Aug; 40(8):2488-91. PMID: 22809916; PMCID: PMC3733455.
    13. Wu D, Molofsky A, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011 Apr 08; 332(6026):243-7. PMID: 21436399; PMCID: PMC3144160.
    14. Molofsky A, Byrne BG, Whitfield NN, Madigan CA, Fuse ET, Tateda K, Swanson MS. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med. 2006 Apr 17; 203(4):1093-104. PMID: 16606669; PMCID: PMC1584282.
    15. Swanson MS, Molofsky A. Autophagy and inflammatory cell death, partners of innate immunity. Autophagy. 2005 Oct-Dec; 1(3):174-6. PMID: 16874072; PMCID: PMC1584281.
    16. Molofsky A, Shetron-Rama LM, Swanson MS. Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infect Immun. 2005 Sep; 73(9):5720-34. PMID: 16113289; PMCID: PMC1231111.
    17. Molofsky A, Swanson MS. Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol Microbiol. 2004 Jul; 53(1):29-40. PMID: 15225301.
      View in: PubMed
    18. Patterson K, Molofsky A, Robinson C, Acosta S, Cater C, Fischer JA. The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye. Mol Biol Cell. 2004 Feb; 15(2):600-10. PMID: 14617811; PMCID: PMC329262.
    19. Molofsky A, Swanson MS. Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication. Mol Microbiol. 2003 Oct; 50(2):445-61. PMID: 14617170.
      View in: PubMed
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