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Vikaas Sohal, MD, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentPsychiatry
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-7377
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    Collapse Research 
    Collapse Research Activities and Funding
    Restoring cognition by optogenetically rescuing gamma rhythms in PFC interneurons
    NIH/NIMH R01MH106507Mar 1, 2015 - Feb 28, 2020
    Role: Principal Investigator
    Identification of enhancers whose activity defines cortical interneuron types
    NIH/NIMH U01MH105948Sep 26, 2014 - Jun 30, 2017
    Role: Co-Principal Investigator
    Cellular and synaptic mechanisms for dopaminergic modulation of prefrontal cortex
    NIH/NIMH R01MH100292Jul 5, 2013 - May 31, 2018
    Role: Principal Investigator
    Reverse engineering the prefrontal microcircuit
    NIH/NIMH DP2MH100011Sep 30, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Optogenetic Tools to Measure Information Processing in Prefrontal Microcircuits
    NIH/NIMH R00MH085946Jul 6, 2009 - May 31, 2013
    Role: Principal Investigator
    Optogenetic Tools to Measure Information Processing in Prefrontal Microcircuits
    NIH/NIMH K99MH085946Jul 6, 2009 - May 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. See JZ, Atencio CA, Sohal V, Schreiner CE. Coordinated neuronal ensembles in primary auditory cortical columns. Elife. 2018 Jun 05; 7. PMID: 29869986.
      View in: PubMed
    2. Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal V, Roche KW, Bender KJ, Nicoll RA. The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. Nat Commun. 2018 May 25; 9(1):2069. PMID: 29802289.
      View in: PubMed
    3. Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil M, Sohal V, Rosi S. Repeated mild head injury leads to wide ranging deficits in higher order cognitive functions associated with the prefrontal cortex. J Neurotrauma. 2018 May 05. PMID: 29732949.
      View in: PubMed
    4. Marton T, Seifikar H, Luongo FJ, Lee AT, Sohal V. Roles of prefrontal cortex and mediodorsal thalamus in task engagement and behavioral flexibility. J Neurosci. 2018 Feb 07. PMID: 29437889.
      View in: PubMed
    5. Vu MT, Adali T, Ba D, Buzsáki G, Carlson D, Heller K, Liston C, Rudin C, Sohal V, Widge AS, Mayberg HS, Sapiro G, Dzirasa K. A Shared Vision for Machine Learning in Neuroscience. J Neurosci. 2018 Feb 14; 38(7):1601-1607. PMID: 29374138.
      View in: PubMed
    6. Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal V, Nicoll RA, Edwards RH. A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. Nat Commun. 2018 01 23; 9(1):330. PMID: 29362376.
      View in: PubMed
    7. Athilingam JC, Ben-Shalom R, Keeshen CM, Sohal V, Bender KJ. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife. 2017 12 05; 6. PMID: 29206101.
      View in: PubMed
    8. Brumback AC, Ellwood IT, Kjaerby C, Iafrati J, Robinson S, Lee AT, Patel T, Nagaraj S, Davatolhagh F, Sohal V. Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. Mol Psychiatry. 2017 Nov 07. PMID: 29112191.
      View in: PubMed
    9. von Schoubye NL, Frederiksen K, Kristiansen U, Petersen AV, Dalby NO, Grunnet M, Jensen HS, Jespersen T, Sohal V, Perrier JF. The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice. Neurosci Lett. 2018 Jan 01; 662:29-35. PMID: 28987817.
      View in: PubMed
    10. Vogt D, Cho KKA, Shelton SM, Paul A, Huang ZJ, Sohal V, Rubenstein JLR. Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons. Cereb Cortex. 2017 Sep 28; 1-12. PMID: 29028946.
      View in: PubMed
    11. Robinson SE, Sohal V. Dopamine D2 Receptors Modulate Pyramidal Neurons in Mouse Medial Prefrontal Cortex through a Stimulatory G-Protein Pathway. J Neurosci. 2017 Oct 18; 37(42):10063-10073. PMID: 28912160.
      View in: PubMed
    12. Wu PR, Cho KKA, Vogt D, Sohal V, Rubenstein JLR. The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex. Cereb Cortex. 2017 Sep 01; 27(9):4303-4313. PMID: 27497284.
      View in: PubMed
    13. Ellwood IT, Patel T, Wadia V, Lee AT, Liptak AT, Bender KJ, Sohal V. Tonic or Phasic Stimulation of Dopaminergic Projections to Prefrontal Cortex Causes Mice to Maintain or Deviate from Previously Learned Behavioral Strategies. J Neurosci. 2017 Aug 30; 37(35):8315-8329. PMID: 28739583.
      View in: PubMed
    14. Clarkson RL, Liptak AT, Gee SM, Sohal V, Bender KJ. D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells. J Neurosci. 2017 Jun 14; 37(24):5846-5860. PMID: 28522735.
      View in: PubMed
    15. Nahum M, Van Vleet TM, Sohal V, Mirzabekov JJ, Rao VR, Wallace DL, Lee MB, Dawes H, Stark-Inbar A, Jordan JT, Biagianti B, Merzenich M, Chang EF. Immediate Mood Scaler: Tracking Symptoms of Depression and Anxiety Using a Novel Mobile Mood Scale. JMIR Mhealth Uhealth. 2017 Apr 12; 5(4):e44. PMID: 28404542.
      View in: PubMed
    16. Khoshkhoo S, Vogt D, Sohal V. Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures. Neuron. 2017 Jan 18; 93(2):291-298. PMID: 28041880.
      View in: PubMed
    17. Kjaerby C, Athilingam J, Robinson SE, Iafrati J, Sohal V. Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs. Cell Rep. 2016 12 13; 17(11):2882-2890. PMID: 27974203.
      View in: PubMed
    18. Martin PM, Stanley RE, Ross AP, Freitas AE, Moyer CE, Brumback AC, Iafrati J, Stapornwongkul KS, Dominguez S, Kivimäe S, Mulligan KA, Pirooznia M, McCombie WR, Potash JB, Zandi PP, Purcell SM, Sanders SJ, Zuo Y, Sohal V, Cheyette BNR. DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/ß-catenin signaling. Mol Psychiatry. 2018 Feb; 23(2):467-475. PMID: 27752079.
      View in: PubMed
    19. Sohal V. How Close Are We to Understanding What (if Anything) ? Oscillations Do in Cortical Circuits? J Neurosci. 2016 Oct 12; 36(41):10489-10495. PMID: 27733600.
      View in: PubMed
    20. Lee AT, Sohal V. Making the Right Connections. Biol Psychiatry. 2016 10 01; 80(7):502-3. PMID: 27601338.
      View in: PubMed
    21. Levy ES, Tajon CA, Bischof TS, Iafrati J, Fernandez-Bravo A, Garfield DJ, Chamanzar M, Maharbiz MM, Sohal V, Schuck PJ, Cohen BE, Chan EM. Energy-Looping Nanoparticles: Harnessing Excited-State Absorption for Deep-Tissue Imaging. ACS Nano. 2016 Sep 27; 10(9):8423-33. PMID: 27603228.
      View in: PubMed
    22. Kirkby LA, Sohal V. Stressing out the Social Network. Neuron. 2016 07 20; 91(2):210-3. PMID: 27477012.
      View in: PubMed
    23. Luongo FJ, Zimmerman CA, Horn ME, Sohal V. Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity. J Neurophysiol. 2016 05 01; 115(5):2359-75. PMID: 26888108.
      View in: PubMed
    24. Luo X, Gee S, Sohal V, Small D. A point-process response model for spike trains from single neurons in neural circuits under optogenetic stimulation. Stat Med. 2016 Feb 10; 35(3):455-74. PMID: 26411923; PMCID: PMC4713323 [Available on 02/10/17].
    25. Mathalon DH, Sohal V. Neural Oscillations and Synchrony in Brain Dysfunction and Neuropsychiatric Disorders: It's About Time. JAMA Psychiatry. 2015 Aug; 72(8):840-4. PMID: 26039190.
      View in: PubMed
    26. Chamanzar M, Garfield DJ, Iafrati J, Sohal V, Chan E, Cohen B, Schuck PJ, Maharbiz MM. Deep tissue targeted near-infrared optogenetic stimulation using fully implantable upconverting light bulbs. Conf Proc IEEE Eng Med Biol Soc. 2015 08; 2015:821-4. PMID: 26736388.
      View in: PubMed
    27. Vogt D, Cho KKA, Lee AT, Sohal V, Rubenstein JLR. The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. Cell Rep. 2015 May 12; 11(6):944-956. PMID: 25937288.
      View in: PubMed
    28. Luongo FJ, Horn ME, Sohal V. Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism. Biol Psychiatry. 2016 Apr 15; 79(8):667-75. PMID: 26022075; PMCID: PMC4624609 [Available on 04/15/17].
    29. Marton TF, Sohal V. Of Mice, Men, and Microbial Opsins: How Optogenetics Can Help Hone Mouse Models of Mental Illness. Biol Psychiatry. 2016 Jan 01; 79(1):47-52. PMID: 25981174; PMCID: PMC4618781 [Available on 01/01/17].
    30. Cho KK, Hoch R, Lee AT, Patel T, Rubenstein JL, Sohal V. Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice. Neuron. 2015 Mar 18; 85(6):1332-43. PMID: 25754826; PMCID: PMC4503262.
    31. Sohal V. Identifying pathways leading to prefrontal GABA-ergic interneuron dysfunction in schizophrenia. Am J Psychiatry. 2014 Sep; 171(9):906-9. PMID: 25178745.
      View in: PubMed
    32. Lee AT, Vogt D, Rubenstein JL, Sohal V. A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior. J Neurosci. 2014 Aug 27; 34(35):11519-25. PMID: 25164650; PMCID: PMC4145166.
    33. Cho KK, Sohal V. Optogenetic approaches for investigating neural pathways implicated in schizophrenia and related disorders. Hum Mol Genet. 2014 Sep 15; 23(R1):R64-8. PMID: 24824218.
      View in: PubMed
    34. Lee AT, Gee SM, Vogt D, Patel T, Rubenstein JL, Sohal V. Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Neuron. 2014 Jan 08; 81(1):61-8. PMID: 24361076; PMCID: PMC3947199.
    35. Seybold BA, Stanco A, Cho KK, Potter GB, Kim C, Sohal V, Rubenstein JL, Schreiner CE. Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13829-34. PMID: 22753490; PMCID: PMC3427089.
    36. Gee S, Ellwood I, Patel T, Luongo F, Deisseroth K, Sohal V. Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex. J Neurosci. 2012 Apr 04; 32(14):4959-71. PMID: 22492051; PMCID: PMC3352768.
    37. Sohal V. Insights into cortical oscillations arising from optogenetic studies. Biol Psychiatry. 2012 Jun 15; 71(12):1039-45. PMID: 22381731; PMCID: PMC3361599.
    38. Sohal V, Sun FT. Responsive neurostimulation suppresses synchronized cortical rhythms in patients with epilepsy. Neurosurg Clin N Am. 2011 Oct; 22(4):481-8, vi. PMID: 21939847.
      View in: PubMed
    39. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal V, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 2011 Jul 27; 477(7363):171-8. PMID: 21796121; PMCID: PMC4155501.
    40. Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL. Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14; 30(15):5334-45. PMID: 20392955; PMCID: PMC2919857.
    41. Gunaydin LA, Yizhar O, Berndt A, Sohal V, Deisseroth K, Hegemann P. Ultrafast optogenetic control. Nat Neurosci. 2010 Mar; 13(3):387-92. PMID: 20081849.
      View in: PubMed
    42. Sohal V, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature. 2009 Jun 04; 459(7247):698-702. PMID: 19396159; PMCID: PMC3969859.
    43. Sohal V, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci. 2006 Apr 19; 26(16):4247-55. PMID: 16624945.
      View in: PubMed
    44. Sohal V, Huguenard JR. Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18638-43. PMID: 16339306; PMCID: PMC1317969.
    45. Sohal V, Huguenard JR. Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus. J Neurosci. 2003 Oct 01; 23(26):8978-88. PMID: 14523100.
      View in: PubMed
    46. Sohal V, Keist R, Rudolph U, Huguenard JR. Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci. 2003 May 01; 23(9):3649-57. PMID: 12736336.
      View in: PubMed
    47. Sohal V, Huguenard JR. It takes T to tango. Neuron. 2001 Jul 19; 31(1):3-4. PMID: 11498042.
      View in: PubMed
    48. Sohal V, Huntsman MM, Huguenard JR. Reciprocal inhibitory connections regulate the spatiotemporal properties of intrathalamic oscillations. J Neurosci. 2000 Mar 01; 20(5):1735-45. PMID: 10684875.
      View in: PubMed
    49. Sohal V, Huguenard JR. Long-range connections synchronize rather than spread intrathalamic oscillations: computational modeling and in vitro electrophysiology. J Neurophysiol. 1998 Oct; 80(4):1736-51. PMID: 9772235.
      View in: PubMed
    50. Sohal V, Cox CL, Huguenard JR. Localization of CCK receptors in thalamic reticular neurons: a modeling study. J Neurophysiol. 1998 May; 79(5):2820-4. PMID: 9582249.
      View in: PubMed