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Babak Javid, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
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ORCID ORCID Icon0000-0002-6354-6305 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of CambridgeBA06/1995Medical Sciences, Psychology & Neurobiology
    University of Cambridge Clinical SchoolMB BChir12/1997Medicine and Surgery
    Hammersmith & University College Hospitals, London04/2001Internal Medicine Residency
    University of CambridgePhD05/2006Immunobiology
    Cambridge University Hospitals09/2007Infectious Diseases Fellowship
    Harvard Chan School of Public Health09/2011Postdoctoral training
    Collapse Awards and Honors
    Wellcome Trust2017  - --Investigator

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Selective translation by alternative bacterial ribosomes. Proc Natl Acad Sci U S A. 2020 Jul 28. Chen YX, Xu ZY, Ge X, Sanyal S, Lu ZJ, Javid B. PMID: 32723820.
      View in: PubMed   Mentions:    Fields:    
    2. Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner. Sci Rep. 2020 May 22; 10(1):8485. Chen Y, Sun T, Bi Z, Ni JQ, Pastor-Pareja JC, Javid B. PMID: 32444687.
      View in: PubMed   Mentions:    Fields:    
    3. Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance. Sci Rep. 2020 May 21; 10(1):8402. Wang BW, Zhu JH, Javid B. PMID: 32439911.
      View in: PubMed   Mentions:    Fields:    
    4. Covid-19: should the public wear face masks? BMJ. 2020 04 09; 369:m1442. Javid B, Weekes MP, Matheson NJ. PMID: 32273278.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    5. HspX promotes the polar localization of mycobacterial protein aggregates. Sci Rep. 2019 10 10; 9(1):14571. Zhang YW, Zhu JH, Wang ZQ, Wu Y, Meng X, Zheng X, Javid B. PMID: 31601950.
      View in: PubMed   Mentions: 1     Fields:    
    6. Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. ACS Infect Dis. 2019 07 12; 5(7):1087-1104. Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G. PMID: 31016962.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems. J Vis Exp. 2019 04 26; (146). Chen YX, Pan M, Chen YM, Javid B. PMID: 31081825.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription. Nat Commun. 2018 10 11; 9(1):4218. Zhu JH, Wang BW, Pan M, Zeng YN, Rego H, Javid B. PMID: 30310059.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. More than merely drug resistance. Nat Microbiol. 2018 10; 3(10):1078-1079. Chen YX, Javid B. PMID: 30254331.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. Transmission of toxigenic Corynebacterium diphtheriae by a fully immunised resident returning from a visit to West Africa, United Kingdom, 2017. Euro Surveill. 2018 09; 23(39). Edwards D, Kent D, Lester C, Brown CS, Murphy ME, Brown NM, Sule O, Itani A, Chand M, Trindall A, Pearson C, Roddick I, Fry NK, Hoffmann J, Iyanger N, Kemp L, White J, Javid B, Ramsay ID, Zenner D, Ahmed A, Amirthalingam G, Salimee S, Litt D, Reacher M. PMID: 30280689.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    11. Antibodies and tuberculosis: finally coming of age? Nat Rev Immunol. 2018 09; 18(9):591-596. Li H, Javid B. PMID: 29872140.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation. Elife. 2018 08 28; 7. Chaudhuri S, Li L, Zimmerman M, Chen Y, Chen YX, Toosky MN, Gardner M, Pan M, Li YY, Kawaji Q, Zhu JH, Su HW, Martinot AJ, Rubin EJ, Dartois VA, Javid B. PMID: 30152756.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2017 05 09; 114(19):5023-5028. Li H, Wang XX, Wang B, Fu L, Liu G, Lu Y, Cao M, Huang H, Javid B. PMID: 28438994.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCellsPHPublic HealthCTClinical Trials
    14. Over-Expression of the Mycobacterial Trehalose-Phosphate Phosphatase OtsB2 Results in a Defect in Macrophage Phagocytosis Associated with Increased Mycobacterial-Macrophage Adhesion. Front Microbiol. 2016; 7:1754. Li H, Wu M, Shi Y, Javid B. PMID: 27867377.
      View in: PubMed   Mentions:
    15. The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity. Nat Microbiol. 2016 Aug 26; 1(11):16147. Su HW, Zhu JH, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B. PMID: 27564922.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    16. Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth. Front Microbiol. 2016; 7:1086. Long J, Basu Roy R, Zhang YJ, Antrobus R, Du Y, Smith DL, Weekes MP, Javid B. PMID: 27462310.
      View in: PubMed   Mentions:
    17. dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains. Antimicrob Agents Chemother. 2016 06; 60(6):3864-7. Moradigaravand D, Grandjean L, Martinez E, Li H, Zheng J, Coronel J, Moore D, Török ME, Sintchenko V, Huang H, Javid B, Parkhill J, Peacock SJ, Köser CU. PMID: 27021327.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Whole-genome sequencing for the diagnosis of drug-resistant tuberculosis. Lancet Infect Dis. 2016 Jan; 16(1):17. Javid B, Török ME. PMID: 26738825.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Translational misreading in Mycobacterium smegmatis increases in stationary phase. Tuberculosis (Edinb). 2015 Dec; 95(6):678-681. Leng T, Pan M, Xu X, Javid B. PMID: 26542220.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    20. Uniform and amorphous rifampicin microspheres obtained by freezing induced LLPS during lyophilization. Int J Pharm. 2015 Nov 10; 495(1):500-507. Liu C, Kong C, Wu G, Zhu J, Javid B, Qian F. PMID: 26383842.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results. J Clin Microbiol. 2015 Aug; 53(8):2781-4. Li H, Kayani Mu, Gu Y, Wang X, Zhu T, Duan H, Ma Y, Huang H, Javid B. PMID: 26063862.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Tuberculosis: hey there, lonely guy! Mol Cell. 2015 Mar 19; 57(6):951-952. Zhu JH, Javid B. PMID: 25794612.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. Drug-resistance mechanisms and tuberculosis drugs. Lancet. 2015 Jan 24; 385(9965):305-7. Köser CU, Javid B, Liddell K, Ellington MJ, Feuerriegel S, Niemann S, Brown NM, Burman WJ, Abubakar I, Ismail NA, Moore D, Peacock SJ, Török ME. PMID: 25706840.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Protein mistranslation: friend or foe? Trends Biochem Sci. 2014 Aug; 39(8):355-62. Ribas de Pouplana L, Santos MA, Zhu JH, Farabaugh PJ, Javid B. PMID: 25023410.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    25. Prevalence and drug resistance of nontuberculous mycobacteria, northern China, 2008-2011. Emerg Infect Dis. 2014 Jul; 20(7):1252-3. Wang X, Li H, Jiang G, Zhao L, Ma Y, Javid B, Huang H. PMID: 24959839.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. Novel diagnostics and therapeutics for drug-resistant tuberculosis. Br Med Bull. 2014 Jun; 110(1):129-40. Toosky M, Javid B. PMID: 24810849.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1132-7. Javid B, Sorrentino F, Toosky M, Zheng W, Pinkham JT, Jain N, Pan M, Deighan P, Rubin EJ. PMID: 24395793.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    28. Functional role of methylation of G518 of the 16S rRNA 530 loop by GidB in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2013 Dec; 57(12):6311-8. Wong SY, Javid B, Addepalli B, Piszczek G, Strader MB, Limbach PA, Barry CE. PMID: 24100503.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    29. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother. 2012 Jan; 56(1):324-31. La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E. PMID: 22024828.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    30. Nanotubes: shaking hands, talking, or sharing? Front Microbiol. 2011; 2:95. Javid B, Derbyshire KM. PMID: 21833333.
      View in: PubMed   Mentions:
    31. Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F950-8. Su Y, Blake-Palmer KG, Sorrell S, Javid B, Bowers K, Zhou A, Chang SH, Qamar S, Karet FE. PMID: 18632794.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. A 58-year-old woman with abdominal symptoms and elevated C-reactive protein. PLoS Med. 2008 Jul 01; 5(7):e149. Daly ML, Cartwright DJ, Lehner PJ, Javid B. PMID: 18597553.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. A case of Mycoplasma hominis septic arthritis postpartum. J Infect. 2007 Nov; 55(5):e135-7. Phuah CL, Javid B, Aliyu SH, Lever AM. PMID: 17892899.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    34. Structure and function: heat shock proteins and adaptive immunity. J Immunol. 2007 Aug 15; 179(4):2035-40. Javid B, MacAry PA, Lehner PJ. PMID: 17675458.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    35. Schistosomal colonic polyposis in an HIV-positive man. AIDS. 2007 Jan 30; 21(3):386-8. Javid B, Aliyu SH, Save VE, Carmichael AJ, Lever AM. PMID: 17255754.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    36. Peptides complexed with the protein HSP70 generate efficient human cytolytic T-lymphocyte responses. Biochem Soc Trans. 2004 Aug; 32(Pt 4):622-5. Javid B, MacAry PA, Oehlmann W, Singh M, Lehner PJ. PMID: 15270691.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding. Tissue Antigens. 2004 Apr; 63(4):345-54. Watkins NA, Dafforn TR, Kuijpers M, Brown C, Javid B, Lehner PJ, Navarrete C, Ouwehand WH. PMID: 15009806.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    38. HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation. Immunity. 2004 Jan; 20(1):95-106. MacAry PA, Javid B, Floto RA, Smith KG, Oehlmann W, Singh M, Lehner PJ. PMID: 14738768.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    39. High rates of tuberculosis in end-stage renal failure: the impact of international migration. Emerg Infect Dis. 2002 Jan; 8(1):77-8. Moore DA, Lightstone L, Javid B, Friedland JS. PMID: 11749753.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
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