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Grae Davis, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentBiochemistry and Biophysics
Address1550 Fourth St
San Francisco CA 94158
Phone415-418-3662
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    Other Positions
    TitleChair, Biochemistry and Biophysics


    Collapse Research 
    Collapse Research Activities and Funding
    Homeostatic Stabilization of Neural Function in Health and Disease
    NIH R35NS097212Dec 1, 2016 - Nov 30, 2024
    Role: Principal Investigator
    2014 Cell Biology of the Neuron Gordon Research Conference
    NIH R13NS088919Jun 21, 2014 - Nov 30, 2014
    Role: Principal Investigator
    Homeostatic Synaptic Depression
    NIH R01NS079307Jun 1, 2012 - Nov 30, 2016
    Role: Principal Investigator
    Trans-Synaptic Signaling during Neuromuscular Development
    NIH R01NS059867Jul 1, 2007 - Jun 30, 2016
    Role: Principal Investigator
    Clathrin Photoinactivation
    NIH R21MH072698Sep 30, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Molecular and Cellular Mechanisms of Synaptic Growth
    NIH R37NS047342Dec 1, 2003 - Jul 31, 2017
    Role: Principal Investigator
    Molecular and Cellular Mechanisms of Synaptic Growth
    NIH R01NS047342Dec 1, 2003 - Jul 31, 2013
    Role: Principal Investigator
    Genome-wide GFP Protein Trap
    NIH R21NS044020Aug 15, 2002 - Jul 31, 2004
    Role: Principal Investigator
    A Genetic Analysis of Synaptic Homeostasis
    NIH R01NS039313Feb 1, 2000 - Apr 30, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Genç Ö, Dickman DK, Ma W, Tong A, Fetter RD, Davis G. MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticity. Elife. 2017 May 09; 6. PMID: 28485711.
      View in: PubMed
    2. Wang T, Jones RT, Whippen JM, Davis G. a2d-3 Is Required for Rapid Transsynaptic Homeostatic Signaling. Cell Rep. 2016 Sep 13; 16(11):2875-88. PMID: 27626659.
      View in: PubMed
    3. Harris N, Braiser DJ, Dickman DK, Fetter RD, Tong A, Davis G. The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity. Neuron. 2015 Dec 16; 88(6):1157-64. PMID: 26687223.
      View in: PubMed
    4. Johnson AE, Shu H, Hauswirth AG, Tong A, Davis G. VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. Elife. 2015; 4. PMID: 26167652; PMCID: PMC4574298.
    5. Gaviño MA, Ford KJ, Archila S, Davis G. Homeostatic synaptic depression is achieved through a regulated decrease in presynaptic calcium channel abundance. Elife. 2015; 4. PMID: 25884248; PMCID: PMC4443758.
    6. Müller M, Genç Ö, Davis G. RIM-binding protein links synaptic homeostasis to the stabilization and replenishment of high release probability vesicles. Neuron. 2015 Mar 4; 85(5):1056-69. PMID: 25704950; PMCID: PMC4354699 [Available on 03/04/16].
    7. Davis G, Müller M. Homeostatic control of presynaptic neurotransmitter release. Annu Rev Physiol. 2015; 77:251-70. PMID: 25386989.
      View in: PubMed
    8. Ford KJ, Davis G. Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction. J Neurosci. 2014 Oct 29; 34(44):14517-25. PMID: 25355206; PMCID: PMC4212058.
    9. Wang T, Hauswirth AG, Tong A, Dickman DK, Davis G. Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity. Neuron. 2014 Aug 6; 83(3):616-29. PMID: 25066085; PMCID: PMC4133507.
    10. Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis G. Krüppel mediates the selective rebalancing of ion channel expression. Neuron. 2014 May 7; 82(3):537-44. PMID: 24811378; PMCID: PMC4104505.
    11. Davis G. Homeostatic signaling and the stabilization of neural function. Neuron. 2013 Oct 30; 80(3):718-28. PMID: 24183022; PMCID: PMC3856728.
    12. Younger MA, Müller M, Tong A, Pym EC, Davis G. A presynaptic ENaC channel drives homeostatic plasticity. Neuron. 2013 Sep 18; 79(6):1183-96. PMID: 23973209; PMCID: PMC3784986.
    13. Müller M, Liu KS, Sigrist SJ, Davis G. RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool. J Neurosci. 2012 Nov 21; 32(47):16574-85. PMID: 23175813; PMCID: PMC3523185.
    14. Dickman DK, Tong A, Davis G. Snapin is critical for presynaptic homeostatic plasticity. J Neurosci. 2012 Jun 20; 32(25):8716-24. PMID: 22723711; PMCID: PMC3395587.
    15. Müller M, Davis G. Transsynaptic control of presynaptic Ca²? influx achieves homeostatic potentiation of neurotransmitter release. Curr Biol. 2012 Jun 19; 22(12):1102-8. PMID: 22633807; PMCID: PMC4367479.
    16. Keller LC, Cheng L, Locke CJ, Müller M, Fetter RD, Davis G. Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. Neuron. 2011 Dec 8; 72(5):760-75. PMID: 22153373; PMCID: PMC3313621.
    17. Graf ER, Heerssen HM, Wright CM, Davis G, DiAntonio A. Stathmin is required for stability of the Drosophila neuromuscular junction. J Neurosci. 2011 Oct 19; 31(42):15026-34. PMID: 22016536; PMCID: PMC3207242.
    18. Cheng L, Locke C, Davis G. S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development. J Cell Biol. 2011 Sep 19; 194(6):921-35. PMID: 21930778; PMCID: PMC3207287.
    19. Eddison M, Guarnieri DJ, Cheng L, Liu CH, Moffat KG, Davis G, Heberlein U. arouser reveals a role for synapse number in the regulation of ethanol sensitivity. Neuron. 2011 Jun 9; 70(5):979-90. PMID: 21658589.
      View in: PubMed
    20. Pielage J, Bulat V, Zuchero JB, Fetter RD, Davis G. Hts/Adducin controls synaptic elaboration and elimination. Neuron. 2011 Mar 24; 69(6):1114-31. PMID: 21435557; PMCID: PMC3073818.
    21. Müller M, Pym EC, Tong A, Davis G. Rab3-GAP controls the progression of synaptic homeostasis at a late stage of vesicle release. Neuron. 2011 Feb 24; 69(4):749-62. PMID: 21338884; PMCID: PMC3059509.
    22. Müller M, Davis G. Vesicle priming in a SNAP. Neuron. 2010 Nov 4; 68(3):324-6. PMID: 21040835; PMCID: PMC4372602.
    23. Marie B, Pym E, Bergquist S, Davis G. Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog. J Neurosci. 2010 Jun 16; 30(24):8071-82. PMID: 20554858; PMCID: PMC3291498.
    24. Bergquist S, Dickman DK, Davis G. A hierarchy of cell intrinsic and target-derived homeostatic signaling. Neuron. 2010 Apr 29; 66(2):220-34. PMID: 20434999; PMCID: PMC2864777.
    25. Dickman DK, Davis G. The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science. 2009 Nov 20; 326(5956):1127-30. PMID: 19965435; PMCID: PMC3063306.
    26. Massaro CM, Pielage J, Davis G. Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton. J Cell Biol. 2009 Oct 5; 187(1):101-17. PMID: 19805631; PMCID: PMC2762090.
    27. Johnson EL, Fetter RD, Davis G. Negative regulation of active zone assembly by a newly identified SR protein kinase. PLoS Biol. 2009 Sep; 7(9):e1000193. PMID: 19771148; PMCID: PMC2737616.
    28. Frank CA, Pielage J, Davis G. A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. Neuron. 2009 Feb 26; 61(4):556-69. PMID: 19249276; PMCID: PMC2699049.
    29. Pawson C, Eaton BA, Davis G. Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules. J Neurosci. 2008 Oct 29; 28(44):11111-23. PMID: 18971454; PMCID: PMC2654187.
    30. Pielage J, Cheng L, Fetter RD, Carlton PM, Sedat JW, Davis G. A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion. Neuron. 2008 Apr 24; 58(2):195-209. PMID: 18439405; PMCID: PMC2699047.
    31. Heerssen H, Fetter RD, Davis G. Clathrin dependence of synaptic-vesicle formation at the Drosophila neuromuscular junction. Curr Biol. 2008 Mar 25; 18(6):401-9. PMID: 18356056; PMCID: PMC2699046.
    32. Goold CP, Davis G. The BMP ligand Gbb gates the expression of synaptic homeostasis independent of synaptic growth control. Neuron. 2007 Oct 4; 56(1):109-23. PMID: 17920019; PMCID: PMC2699048.
    33. Heckscher ES, Fetter RD, Marek KW, Albin SD, Davis G. NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ. Neuron. 2007 Sep 20; 55(6):859-73. PMID: 17880891; PMCID: PMC2701504.
    34. Frank CA, Kennedy MJ, Goold CP, Marek KW, Davis G. Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Neuron. 2006 Nov 22; 52(4):663-77. PMID: 17114050; PMCID: PMC2673733.
    35. Pielage J, Fetter RD, Davis G. A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction. J Cell Biol. 2006 Nov 6; 175(3):491-503. PMID: 17088429; PMCID: PMC2064525.
    36. Poskanzer KE, Fetter RD, Davis G. Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size. Neuron. 2006 Apr 6; 50(1):49-62. PMID: 16600855.
      View in: PubMed
    37. Davis G. Homeostatic control of neural activity: from phenomenology to molecular design. Annu Rev Neurosci. 2006; 29:307-23. PMID: 16776588.
      View in: PubMed
    38. Eaton BA, Davis G. LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor. Neuron. 2005 Sep 1; 47(5):695-708. PMID: 16129399.
      View in: PubMed
    39. Pielage J, Fetter RD, Davis G. Presynaptic spectrin is essential for synapse stabilization. Curr Biol. 2005 May 24; 15(10):918-28. PMID: 15916948.
      View in: PubMed
    40. Poskanzer KE, Davis G. Mobilization and fusion of a non-recycling pool of synaptic vesicles under conditions of endocytic blockade. Neuropharmacology. 2004 Oct; 47(5):714-23. PMID: 15458843.
      View in: PubMed
    41. Albin SD, Davis G. Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. J Neurosci. 2004 Aug 4; 24(31):6871-9. PMID: 15295021.
      View in: PubMed
    42. Marie B, Sweeney ST, Poskanzer KE, Roos J, Kelly RB, Davis G. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Neuron. 2004 Jul 22; 43(2):207-19. PMID: 15260957.
      View in: PubMed
    43. Poskanzer KE, Marek KW, Sweeney ST, Davis G. Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature. 2003 Dec 4; 426(6966):559-63. PMID: 14634669.
      View in: PubMed
    44. Clyne PJ, Brotman JS, Sweeney ST, Davis G. Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements. Genetics. 2003 Nov; 165(3):1433-41. PMID: 14668392; PMCID: PMC1462835.
    45. Marek KW, Davis G. Controlling the active properties of excitable cells. Curr Opin Neurobiol. 2003 Oct; 13(5):607-11. PMID: 14630226.
      View in: PubMed
    46. Eaton BA, Davis G. Synapse disassembly. Genes Dev. 2003 Sep 1; 17(17):2075-82. PMID: 12952887.
      View in: PubMed
    47. Marek KW, Davis G. Transgenically encoded protein photoinactivation (FlAsH-FALI): acute inactivation of synaptotagmin I. Neuron. 2002 Dec 5; 36(5):805-13. PMID: 12467585.
      View in: PubMed
    48. Sweeney ST, Davis G. Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation. Neuron. 2002 Oct 24; 36(3):403-16. PMID: 12408844.
      View in: PubMed
    49. Eaton BA, Fetter RD, Davis G. Dynactin is necessary for synapse stabilization. Neuron. 2002 May 30; 34(5):729-41. PMID: 12062020.
      View in: PubMed
    50. Paradis S, Sweeney ST, Davis G. Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization. Neuron. 2001 Jun; 30(3):737-49. PMID: 11430807.
      View in: PubMed
    51. Davis G, Eaton B, Paradis S. Synapse formation revisited. Nat Neurosci. 2001 Jun; 4(6):558-60. PMID: 11369932.
      View in: PubMed
    52. Davis G, Bezprozvanny I. Maintaining the stability of neural function: a homeostatic hypothesis. Annu Rev Physiol. 2001; 63:847-69. PMID: 11181978.
      View in: PubMed
    53. Davis G. The making of a synapse: target-derived signals and presynaptic differentiation. Neuron. 2000 Jun; 26(3):551-4. PMID: 10896150.
      View in: PubMed
    54. Marek KW, Ng N, Fetter R, Smolik S, Goodman CS, Davis G. A genetic analysis of synaptic development: pre- and postsynaptic dCBP control transmitter release at the Drosophila NMJ. Neuron. 2000 Mar; 25(3):537-47. PMID: 10774723.
      View in: PubMed
    55. Davis G, Goodman CS. Synapse-specific control of synaptic efficacy at the terminals of a single neuron. Nature. 1998 Mar 5; 392(6671):82-6. PMID: 9510251.
      View in: PubMed
    56. Davis G, DiAntonio A, Petersen SA, Goodman CS. Postsynaptic PKA controls quantal size and reveals a retrograde signal that regulates presynaptic transmitter release in Drosophila. Neuron. 1998 Feb; 20(2):305-15. PMID: 9491991.
      View in: PubMed
    57. Davis G, Goodman CS. Genetic analysis of synaptic development and plasticity: homeostatic regulation of synaptic efficacy. Curr Opin Neurobiol. 1998 Feb; 8(1):149-56. PMID: 9568402.
      View in: PubMed
    58. Davis G, Schuster CM, Goodman CS. Genetic analysis of the mechanisms controlling target selection: target-derived Fasciclin II regulates the pattern of synapse formation. Neuron. 1997 Sep; 19(3):561-73. PMID: 9331349.
      View in: PubMed
    59. Goodman CS, Davis G, Zito K. The many faces of fasciclin II: Genetic analysis reveals multiple roles for a cell adhesion molecule during the generation of neuronal specificity. Cold Spring Harb Symp Quant Biol. 1997; 62:479-91. PMID: 9598382.
      View in: PubMed
    60. Davis G, Schuster CM, Goodman CS. Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron. 1996 Oct; 17(4):669-79. PMID: 8893024.
      View in: PubMed
    61. Schuster CM, Davis G, Fetter RD, Goodman CS. Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron. 1996 Oct; 17(4):655-67. PMID: 8893023.
      View in: PubMed
    62. Schuster CM, Davis G, Fetter RD, Goodman CS. Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron. 1996 Oct; 17(4):641-54. PMID: 8893022.
      View in: PubMed
    63. Kopczynski CC, Davis G, Goodman CS. A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation. Science. 1996 Mar 29; 271(5257):1867-70. PMID: 8596956.
      View in: PubMed
    64. Davis G. Long-term regulation of short-term plasticity: a postsynaptic influence on presynaptic transmitter release. J Physiol Paris. 1995; 89(1):33-41. PMID: 7581297.
      View in: PubMed
    65. Davis G, Murphey RK. Retrograde signaling and the development of transmitter release properties in the invertebrate nervous system. J Neurobiol. 1994 Jun; 25(6):740-56. PMID: 7915302.
      View in: PubMed
    66. Davis G, Murphey RK. Long-term regulation of short-term transmitter release properties: retrograde signaling and synaptic development. Trends Neurosci. 1994 Jan; 17(1):9-13. PMID: 7511852.
      View in: PubMed
    67. Davis G, Murphey RK. A role for postsynaptic neurons in determining presynaptic release properties in the cricket CNS: evidence for retrograde control of facilitation. J Neurosci. 1993 Sep; 13(9):3827-38. PMID: 8366348.
      View in: PubMed
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