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Rada Savic, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address1700 4th St
San Francisco CA 94158
Phone415-502-0640
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    Collapse Biography 
    Collapse Education and Training
    Uppsala UniversityPhD2008School of Pharmacy
    Uppsala Graduate School in Biomedical ResearchMSc2004
    Belgrade UniversityBSc2003School of Pharmacy
    Collapse Awards and Honors
    PhRMA Foundation2013  - 2013Researcher Starter Grant
    KL22013  - 2013UCSF Career Award
    American Society for Clinical Pharmacology & Therapeutics2021  - 2021Leon I. Goldberg Early Investigator Award Lecture

    Collapse Overview 
    Collapse Overview
    My research uses computational methods to study the dynamic interplay between disease progression, drug and biomarker response across relevant scales (molecule, cell, tissue, organ & whole body) in order to determine causal links underlying variability in (safety and efficacy) clinical outcomes. By integrating multi-scale, and multi-level clinical data, we aim to determine the right dose, right schedule and right treatment duration of various therapies, potentially bringing novel, precise and personalized treatment options to patients with unmet need more quickly.

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    Collapse Global Health
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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Piperaquine exposure is altered by pregnancy, HIV and nutritional status in Ugandan women. Antimicrob Agents Chemother. 2020 Oct 05. Hughes E, Imperial M, Wallender E, Kajubi R, Huang L, Jagannathan P, Zhang N, Kakuru A, Natureeba P, Mwima MW, Muhindo M, Mwebaza N, Clark TD, Opira B, Nakalembe M, Havlir D, Kamya M, Rosenthal PJ, Dorsey G, Aweeka F, Savic RM. PMID: 33020153.
      View in: PubMed   Mentions:    Fields:    
    2. Rifapentine Population Pharmacokinetics and Dosing Recommendations for Latent Tuberculosis Infection. Am J Respir Crit Care Med. 2020 09 15; 202(6):866-877. Hibma JE, Radtke KK, Dorman SE, Jindani A, Dooley KE, Weiner M, McIlleron HM, Savic RM. PMID: 32412342.
      View in: PubMed   Mentions: 1     Fields:    
    3. Mathematical model and tool to explore shorter multi-drug therapy options for active pulmonary tuberculosis. PLoS Comput Biol. 2020 08; 16(8):e1008107. Fors J, Strydom N, Fox WS, Keizer RJ, Savic RM. PMID: 32810158.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Development of New Tuberculosis Drugs: Translation to Regimen Composition for Drug-Sensitive and Multidrug-Resistant Tuberculosis. Annu Rev Pharmacol Toxicol. 2020 Aug 17. Ernest JP, Strydom N, Wang Q, Zhang N, Nuermberger E, Dartois V, Savic RM. PMID: 32806997.
      View in: PubMed   Mentions:    Fields:    
    5. Pharmacokinetics and Pharmacological Properties of Chloroquine and Hydroxychloroquine in the Context of COVID-19 Infection. Clin Pharmacol Ther. 2020 Jul 20. Nicol MR, Joshi A, Rizk ML, Sabato PE, Savic RM, Wesche D, Zheng JH, Cook J. PMID: 32687630.
      View in: PubMed   Mentions:    Fields:    
    6. Response to "Quantitative Clinical Pharmacology INPUT to SARS-CoV-2 Therapeutics Should be Based on Robust Data". Clin Pharmacol Ther. 2020 08; 108(2):189. Garcia-Cremades M, Solans BP, Hughes E, Ernest JP, Wallender E, Savic RM. PMID: 32348544.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    7. Optimizing Hydroxychloroquine Dosing for Patients With COVID-19: An Integrative Modeling Approach for Effective Drug Repurposing. Clin Pharmacol Ther. 2020 08; 108(2):253-263. Garcia-Cremades M, Solans BP, Hughes E, Ernest JP, Wallender E, Aweeka F, Luetkemeyer AF, Savic RM. PMID: 32285930.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    8. Early Bactericidal Activity Trial of Nitazoxanide for Pulmonary Tuberculosis. Antimicrob Agents Chemother. 2020 04 21; 64(5). Walsh KF, McAulay K, Lee MH, Vilbrun SC, Mathurin L, Jean Francois D, Zimmerman M, Kaya F, Zhang N, Saito K, Ocheretina O, Savic R, Dartois V, Johnson WD, Pape JW, Nathan C, Fitzgerald DW. PMID: 32071052.
      View in: PubMed   Mentions: 2     Fields:    
    9. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. J Acquir Immune Defic Syndr. 2020 04 15; 83(5):530-537. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM. PMID: 32168200.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Once-weekly rifapentine and isoniazid for tuberculosis prevention in patients with HIV taking dolutegravir-based antiretroviral therapy: a phase 1/2 trial. Lancet HIV. 2020 06; 7(6):e401-e409. Dooley KE, Savic R, Gupte A, Marzinke MA, Zhang N, Edward VA, Wolf L, Sebe M, Likoti M, Fyvie MJ, Shibambo I, Beattie T, Chaisson RE, Churchyard GJ. PMID: 32240629.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsCTClinical Trials
    11. Mechanistic Modeling of Mycobacterium tuberculosis Infection in Murine Models for Drug and Vaccine Efficacy Studies. Antimicrob Agents Chemother. 2020 02 21; 64(3). Zhang N, Strydom N, Tyagi S, Soni H, Tasneen R, Nuermberger EL, Savic RM. PMID: 31907182.
      View in: PubMed   Mentions:    Fields:    
    12. Pharmacodynamic Correlates of Linezolid Activity and Toxicity in Murine Models of Tuberculosis. J Infect Dis. 2020 Jan 29. Bigelow KM, Deitchman AN, Li SY, Barnes-Boyle K, Tyagi S, Soni H, Dooley KE, Savic R, Nuermberger EL. PMID: 31993638.
      View in: PubMed   Mentions: 2     Fields:    
    13. The importance of adherence in tuberculosis treatment clinical trials and its relevance in explanatory and pragmatic trials. PLoS Med. 2019 12; 16(12):e1002884. Vernon A, Fielding K, Savic R, Dodd L, Nahid P. PMID: 31821323.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Results from a Phase 1 Study of Sodium Selenite in Combination with Palliative Radiation Therapy in Patients with Metastatic Cancer. Transl Oncol. 2019 Nov; 12(11):1525-1531. Knox SJ, Jayachandran P, Keeling CA, Stevens KJ, Sandhu N, Stamps-DeAnda SL, Savic R, Shura L, Buyyounouski MK, Grimes K. PMID: 31454725.
      View in: PubMed   Mentions:
    15. Alternative dosing guidelines to improve outcomes in childhood tuberculosis: a mathematical modelling study. Lancet Child Adolesc Health. 2019 09; 3(9):636-645. Radtke KK, Dooley KE, Dodd PJ, Garcia-Prats AJ, McKenna L, Hesseling AC, Savic RM. PMID: 31324596.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Advancing the development of new tuberculosis treatment regimens: The essential role of translational and clinical pharmacology and microbiology. PLoS Med. 2019 07; 16(7):e1002842. Dooley KE, Hanna D, Mave V, Eisenach K, Savic RM. PMID: 31276490.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies. PLoS Med. 2019 04; 16(4):e1002789. Garcia-Prats AJ, Schaaf HS, Draper HR, Garcia-Cremades M, Winckler J, Wiesner L, Hesseling AC, Savic RM. PMID: 31039153.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations. Antimicrob Agents Chemother. 2019 05; 63(5). Sarathy J, Blanc L, Alvarez-Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Ho Liang HP, Prideaux B, Dietzold J, Salgame P, Savic RM, Linderman J, Kirschner D, Pienaar E, Dartois V. PMID: 30803965.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    19. Tuberculosis drugs' distribution and emergence of resistance in patient's lung lesions: A mechanistic model and tool for regimen and dose optimization. PLoS Med. 2019 04; 16(4):e1002773. Strydom N, Gupta SV, Fox WS, Via LE, Bang H, Lee M, Eum S, Shim T, Barry CE, Zimmerman M, Dartois V, Savic RM. PMID: 30939136.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    20. Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda. Antimicrob Agents Chemother. 2019 02; 63(2). Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P, Havlir D, Kamya M, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. PMID: 30530597.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types. Elife. 2018 11 14; 7. Blanc L, Daudelin IB, Podell BK, Chen PY, Zimmerman M, Martinot AJ, Savic RM, Prideaux B, Dartois V. PMID: 30427309.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis. Nat Med. 2018 11; 24(11):1708-1715. Imperial MZ, Nahid P, Phillips PPJ, Davies GR, Fielding K, Hanna D, Hermann D, Wallis RS, Johnson JL, Lienhardt C, Savic RM. PMID: 30397355.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCTClinical Trials
    23. Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial. Clin Pharmacol Ther. 2019 03; 105(3):692-702. Lee SA, Elliott JH, McMahon J, Hartogenesis W, Bumpus NN, Lifson JD, Gorelick RJ, Bacchetti P, Deeks SG, Lewin SR, Savic RM. PMID: 30137649.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    24. Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. Clin Infect Dis. 2018 09 14; 67(7):1079-1088. Savic RM, Jagannathan P, Kajubi R, Huang L, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E, Clark TD, Opira B, Kamya M, Havlir DV, Rosenthal PJ, Dorsey G, Aweeka FT. PMID: 29547881.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Impact of immunopathology on the antituberculous activity of pyrazinamide. J Exp Med. 2018 08 06; 215(8):1975-1986. Blanc L, Sarathy JP, Alvarez Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Sacchettini J, Savic RM, Gengenbacher M, Podell BK, Prideaux B, Ioerger T, Dick T, Dartois V. PMID: 30018074.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data. Sci Transl Med. 2018 04 04; 10(435). Rifat D, Prideaux B, Savic RM, Urbanowski ME, Parsons TL, Luna B, Marzinke MA, Ordonez AA, DeMarco VP, Jain SK, Dartois V, Bishai WR, Dooley KE. PMID: 29618565.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    27. Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz. J Infect Dis. 2018 03 05; 217(6):964-972. Wallender E, Vucicevic K, Jagannathan P, Huang L, Natureeba P, Kakuru A, Muhindo M, Nakalembe M, Havlir D, Kamya M, Aweeka F, Dorsey G, Rosenthal PJ, Savic RM. PMID: 29272443.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications. Clin Pharmacol Ther. 2018 10; 104(4):733-741. Guiastrennec B, Ramachandran G, Karlsson MO, Kumar AKH, Bhavani PK, Gangadevi NP, Swaminathan S, Gupta A, Dooley KE, Savic RM. PMID: 29247506.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis. Clin Pharmacokinet. 2017 10; 56(10):1245-1253. Savic RM, Novakovic AM, Ekblom M, Munafo A, Karlsson MO. PMID: 28255849.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    30. Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors. Breast Cancer Res. 2017 Sep 11; 19(1):107. Bartelink IH, Prideaux B, Krings G, Wilmes L, Lee PRE, Bo P, Hann B, Coppé JP, Heditsian D, Swigart-Brown L, Jones EF, Magnitsky S, Keizer RJ, de Vries N, Rosing H, Pawlowska N, Thomas S, Dhawan M, Aggarwal R, Munster PN, Esserman LJ, Ruan W, Wu AHB, Yee D, Dartois V, Savic RM, Wolf DM, van 't Veer L. PMID: 28893315.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Tuberculous meningitis. Nat Rev Neurol. 2017 Oct; 13(10):581-598. Wilkinson RJ, Rohlwink U, Misra UK, van Crevel R, Mai NTH, Dooley KE, Caws M, Figaji A, Savic R, Solomons R, Thwaites GE. PMID: 28884751.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    32. New Paradigm for Translational Modeling to Predict Long-term Tuberculosis Treatment Response. Clin Transl Sci. 2017 Sep; 10(5):366-379. Bartelink IH, Zhang N, Keizer RJ, Strydom N, Converse PJ, Dooley KE, Nuermberger EL, Savic RM. PMID: 28561946.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Population Pharmacokinetics of Pyrazinamide in Patients with Tuberculosis. Antimicrob Agents Chemother. 2017 06; 61(6). Alsultan A, Savic R, Dooley KE, Weiner M, Whitworth W, Mac Kenzie WR, Peloquin CA. PMID: 28289033.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    34. Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials. Clin Pharmacol Ther. 2017 Aug; 102(2):321-331. Savic RM, Weiner M, MacKenzie WR, Engle M, Whitworth WC, Johnson JL, Nsubuga P, Nahid P, Nguyen NV, Peloquin CA, Dooley KE, Dorman SE. PMID: 28124478.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    35. Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics. CPT Pharmacometrics Syst Pharmacol. 2017 02; 6(2):87-109. Nguyen TH, Mouksassi MS, Holford N, Al-Huniti N, Freedman I, Hooker AC, John J, Karlsson MO, Mould DR, Pérez Ruixo JJ, Plan EL, Savic R, van Hasselt JG, Weber B, Zhou C, Comets E, Mentré F. PMID: 27884052.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    36. Importance of Drug Pharmacokinetics at the Site of Action. Clin Transl Sci. 2017 05; 10(3):133-142. Rizk ML, Zou L, Savic RM, Dooley KE. PMID: 28160433.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    37. Association of busulfan exposure with survival and toxicity after haemopoietic cell transplantation in children and young adults: a multicentre, retrospective cohort analysis. Lancet Haematol. 2016 Nov; 3(11):e526-e536. Bartelink IH, Lalmohamed A, van Reij EM, Dvorak CC, Savic RM, Zwaveling J, Bredius RG, Egberts AC, Bierings M, Kletzel M, Shaw PJ, Nath CE, Hempel G, Ansari M, Krajinovic M, Théorêt Y, Duval M, Keizer RJ, Bittencourt H, Hassan M, Güngör T, Wynn RF, Veys P, Cuvelier GD, Marktel S, Chiesa R, Cowan MJ, Slatter MA, Stricherz MK, Jennissen C, Long-Boyle JR, Boelens JJ. PMID: 27746112.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    38. Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure. J Clin Microbiol. 2016 12; 54(12):3028-3033. Jayakumar A, Savic RM, Everett CK, Benator D, Alland D, Heilig CM, Weiner M, Friedrich SO, Martinson NA, Kerrigan A, Zamudio C, Goldberg SV, Whitworth WC, Davis JL, Nahid P. PMID: 27733634.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsCTClinical Trials
    39. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clin Pharmacol Ther. 2016 Nov; 100(5):537-547. Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. PMID: 27415606.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 06; 55(6):711-21. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. PMID: 26597253.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    41. A Phase 2 Randomized Trial of a Rifapentine plus Moxifloxacin-Based Regimen for Treatment of Pulmonary Tuberculosis. PLoS One. 2016; 11(5):e0154778. Conde MB, Mello FC, Duarte RS, Cavalcante SC, Rolla V, Dalcolmo M, Loredo C, Durovni B, Armstrong DT, Efron A, Barnes GL, Marzinke MA, Savic RM, Dooley KE, Cohn S, Moulton LH, Chaisson RE, Dorman SE. PMID: 27159505.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    42. GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last. Clin Infect Dis. 2016 May 01; 62(9):1133-5. Bahr NC, Marais S, Caws M, van Crevel R, Wilkinson RJ, Tyagi JS, Thwaites GE, Boulware DR. PMID: 26966284.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    43. Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model. Pharm Res. 2016 May; 33(5):1133-43. Larsen MS, Keizer R, Munro G, Mørk A, Holm R, Savic R, Kreilgaard M. PMID: 26780452.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    44. Toward Earlier Inclusion of Pregnant and Postpartum Women in Tuberculosis Drug Trials: Consensus Statements From an International Expert Panel. Clin Infect Dis. 2016 Mar 15; 62(6):761-769. Gupta A, Mathad JS, Abdel-Rahman SM, Albano JD, Botgros R, Brown V, Browning RS, Dawson L, Dooley KE, Gnanashanmugam D, Grinsztejn B, Hernandez-Diaz S, Jean-Philippe P, Kim P, Lyerly AD, Mirochnick M, Mofenson LM, Montepiedra G, Piper J, Sahin L, Savic R, Smith B, Spiegel H, Swaminathan S, Watts DH, White A. PMID: 26658057.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    45. Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study. Lancet HIV. 2015 Dec; 2(12):e520-9. Elliott JH, McMahon JH, Chang CC, Lee SA, Hartogensis W, Bumpus N, Savic R, Roney J, Hoh R, Solomon A, Piatak M, Gorelick RJ, Lifson J, Bacchetti P, Deeks SG, Lewin SR. PMID: 26614966.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCellsCTClinical Trials
    46. Pediatric tuberculous meningitis: Model-based approach to determining optimal doses of the anti-tuberculosis drugs rifampin and levofloxacin for children. Clin Pharmacol Ther. 2015 Dec; 98(6):622-9. Savic RM, Ruslami R, Hibma JE, Hesseling A, Ramachandran G, Ganiem AR, Swaminathan S, McIlleron H, Gupta A, Thakur K, van Crevel R, Aarnoutse R, Dooley KE. PMID: 26260983.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children. Malar J. 2015 Sep 24; 14:368. Sundell K, Jagannathan P, Huang L, Bigira V, Kapisi J, Kakuru MM, Savic R, Kamya MR, Dorsey G, Aweeka F. PMID: 26403465.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    48. Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives. ACS Infect Dis. 2015 May 08; 1(5):203-214. Via LE, Savic R, Weiner DM, Zimmerman MD, Prideaux B, Irwin SM, Lyon E, O'Brien P, Gopal P, Eum S, Lee M, Lanoix JP, Dutta NK, Shim T, Cho JS, Kim W, Karakousis PC, Lenaerts A, Nuermberger E, Barry CE, Dartois V. PMID: 26086040.
      View in: PubMed   Mentions: 31     Fields:    
    49. Population pharmacokinetics of busulfan in pediatric and young adult patients undergoing hematopoietic cell transplant: a model-based dosing algorithm for personalized therapy and implementation into routine clinical use. Ther Drug Monit. 2015 Apr; 37(2):236-45. Long-Boyle JR, Savic R, Yan S, Bartelink I, Musick L, French D, Law J, Horn B, Cowan MJ, Dvorak CC. PMID: 25162216.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    50. Novel dosing strategies increase exposures of the potent antituberculosis drug rifapentine but are poorly tolerated in healthy volunteers. Antimicrob Agents Chemother. 2015; 59(6):3399-405. Dooley KE, Savic RM, Park JG, Cramer Y, Hafner R, Hogg E, Janik J, Marzinke MA, Patterson K, Benson CA, Hovind L, Dorman SE, Haas DW. PMID: 25824215.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    51. The effect of malnutrition on the pharmacokinetics and virologic outcomes of lopinavir, efavirenz and nevirapine in food insecure HIV-infected children in Tororo, Uganda. Pediatr Infect Dis J. 2015 Mar; 34(3):e63-70. Bartelink IH, Savic RM, Dorsey G, Ruel T, Gingrich D, Scherpbier HJ, Capparelli E, Jullien V, Young SL, Achan J, Plenty A, Charlebois E, Kamya M, Havlir D, Aweeka F. PMID: 25742090.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    52. Daily rifapentine for treatment of pulmonary tuberculosis. A randomized, dose-ranging trial. Am J Respir Crit Care Med. 2015 Feb 01; 191(3):333-43. Dorman SE, Savic RM, Goldberg S, Stout JE, Schluger N, Muzanyi G, Johnson JL, Nahid P, Hecker EJ, Heilig CM, Bozeman L, Feng PJ, Moro RN, MacKenzie W, Dooley KE, Nuermberger EL, Vernon A, Weiner M. PMID: 25489785.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    53. Designing drug trials: considerations for pregnant women. Clin Infect Dis. 2014 Dec 15; 59 Suppl 7:S437-44. Sheffield JS, Siegel D, Mirochnick M, Heine RP, Nguyen C, Bergman KL, Savic RM, Long J, Dooley KE, Nesin M. PMID: 25425722.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    54. Impact of adherence and anthropometric characteristics on nevirapine pharmacokinetics and exposure among HIV-infected Kenyan children. . 2014 Nov 01; 67(3):277-86. Vreeman RC, Nyandiko WM, Liechty EA, Busakhala N, Bartelink IH, Savic RM, Scanlon ML, Ayaya SO, Blaschke TF. PMID: 25140906.
      View in: PubMed   Mentions:
    55. Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA-824 with concomitant lopinavir-ritonavir, efavirenz, or rifampin. Antimicrob Agents Chemother. 2014 Sep; 58(9):5245-52. Dooley KE, Luetkemeyer AF, Park JG, Allen R, Cramer Y, Murray S, Sutherland D, Aweeka F, Koletar SL, Marzan F, Bao J, Savic R, Haas DW. PMID: 24957823.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    56. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM. PMID: 24853734.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    57. Population pharmacokinetics of rifapentine and desacetyl rifapentine in healthy volunteers: nonlinearities in clearance and bioavailability. Antimicrob Agents Chemother. 2014 Jun; 58(6):3035-42. Savic RM, Lu Y, Bliven-Sizemore E, Weiner M, Nuermberger E, Burman W, Dorman SE, Dooley KE. PMID: 24614383.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    58. Rifapentine Pharmacokinetics and Tolerability in Children and Adults Treated Once Weekly With Rifapentine and Isoniazid for Latent Tuberculosis Infection. J Pediatric Infect Dis Soc. 2014 Jun; 3(2):132-45. Weiner M, Savic RM, Kenzie WR, Wing D, Peloquin CA, Engle M, Bliven E, Prihoda TJ, Gelfond JA, Scott NA, Abdel-Rahman SM, Kearns GL, Burman WJ, Sterling TR, Villarino ME. PMID: 26625366.
      View in: PubMed   Mentions: 8     Fields:    
    59. Pharmacokinetics of lopinavir/ritonavir and efavirenz in food insecure HIV-infected pregnant and breastfeeding women in Tororo, Uganda. J Clin Pharmacol. 2014 Feb; 54(2):121-32. Bartelink IH, Savic RM, Mwesigwa J, Achan J, Clark T, Plenty A, Charlebois E, Kamya M, Young SL, Gandhi M, Havlir D, Cohan D, Aweeka F. PMID: 24038035.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    60. Effect of weight and maturation on busulfan clearance in infants and small children undergoing hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2013 Nov; 19(11):1608-14. Savic RM, Cowan MJ, Dvorak CC, Pai SY, Pereira L, Bartelink IH, Boelens JJ, Bredius RG, Wynn RF, Cuvelier GD, Shaw PJ, Slatter MA, Long-Boyle J. PMID: 24029650.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    61. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. PMID: 23649425.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    62. Effect of adherence as measured by MEMS, ritonavir boosting, and CYP3A5 genotype on atazanavir pharmacokinetics in treatment-naive HIV-infected patients. Clin Pharmacol Ther. 2012 Nov; 92(5):575-83. Savic RM, Barrail-Tran A, Duval X, Nembot G, Panhard X, Descamps D, Verstuyft C, Vrijens B, Taburet AM, Goujard C, Mentré F. PMID: 23033116.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    63. The pharmacokinetics of oxypurinol in people with gout. Br J Clin Pharmacol. 2012 Sep; 74(3):477-89. Stocker SL, McLachlan AJ, Savic RM, Kirkpatrick CM, Graham GG, Williams KM, Day RO. PMID: 22300439.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    64. Optimising the manufacture, formulation, and dose of antiretroviral drugs for more cost-efficient delivery in resource-limited settings: a consensus statement. Lancet Infect Dis. 2012 Jul; 12(7):550-60. Crawford KW, Ripin DH, Levin AD, Campbell JR, Flexner C. PMID: 22742638.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    65. Analysis of exposure-response of CI-945 in patients with epilepsy: application of novel mixed hidden Markov modeling methodology. J Pharmacokinet Pharmacodyn. 2012 Jun; 39(3):263-71. Delattre M, Savic RM, Miller R, Karlsson MO, Lavielle M. PMID: 22544471.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    66. Standard Error of Empirical Bayes Estimate in NONMEM® VI. Korean J Physiol Pharmacol. 2012 Apr; 16(2):97-106. Kang D, Bae KS, Houk BE, Savic RM, Karlsson MO. PMID: 22563254.
      View in: PubMed   Mentions:
    67. Two bootstrapping routines for obtaining imprecision estimates for nonparametric parameter distributions in nonlinear mixed effects models. J Pharmacokinet Pharmacodyn. 2011 Feb; 38(1):63-82. Baverel PG, Savic RM, Karlsson MO. PMID: 21076858.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    68. Implementation and evaluation of the SAEM algorithm for longitudinal ordered categorical data with an illustration in pharmacokinetics-pharmacodynamics. AAPS J. 2011 Mar; 13(1):44-53. Savic RM, Mentré F, Lavielle M. PMID: 21063925.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    69. Evaluation of an extended grid method for estimation using nonparametric distributions. AAPS J. 2009 Sep; 11(3):615-27. Savic RM, Karlsson MO. PMID: 19714472.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    70. Performance in population models for count data, part II: a new SAEM algorithm. J Pharmacokinet Pharmacodyn. 2009 Aug; 36(4):367-79. Savic R, Lavielle M. PMID: 19680795.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    71. Importance of shrinkage in empirical bayes estimates for diagnostics: problems and solutions. AAPS J. 2009 Sep; 11(3):558-69. Savic RM, Karlsson MO. PMID: 19649712.
      View in: PubMed   Mentions: 199     Fields:    
    72. Evaluation of the nonparametric estimation method in NONMEM VI: application to real data. J Pharmacokinet Pharmacodyn. 2009 Aug; 36(4):297-315. Baverel PG, Savic RM, Wilkins JJ, Karlsson MO. PMID: 19572188.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    73. Semiparametric distributions with estimated shape parameters. Pharm Res. 2009 Sep; 26(9):2174-85. Petersson KJ, Hanze E, Savic RM, Karlsson MO. PMID: 19568693.
      View in: PubMed   Mentions: 28     Fields:    
    74. Modeling subpopulations with the $MIXTURE subroutine in NONMEM: finding the individual probability of belonging to a subpopulation for the use in model analysis and improved decision making. AAPS J. 2009 Mar; 11(1):148-54. Carlsson KC, Savic RM, Hooker AC, Karlsson MO. PMID: 19277871.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    75. Evaluation of the nonparametric estimation method in NONMEM VI. Eur J Pharm Sci. 2009 Apr 11; 37(1):27-35. Savic RM, Kjellsson MC, Karlsson MO. PMID: 19159684.
      View in: PubMed   Mentions: 7     Fields:    
    76. Population pharmacokinetics of rifampin in pulmonary tuberculosis patients, including a semimechanistic model to describe variable absorption. Antimicrob Agents Chemother. 2008 Jun; 52(6):2138-48. Wilkins JJ, Savic RM, Karlsson MO, Langdon G, McIlleron H, Pillai G, Smith PJ, Simonsson US. PMID: 18391026.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    77. Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies. J Pharmacokinet Pharmacodyn. 2007 Oct; 34(5):711-26. Savic RM, Jonker DM, Kerbusch T, Karlsson MO. PMID: 17653836.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansCells
    78. Diagnosing model diagnostics. Clin Pharmacol Ther. 2007 Jul; 82(1):17-20. Karlsson MO, Savic RM. PMID: 17571070.
      View in: PubMed   Mentions: 169     Fields:    Translation:Humans
    79. Population Pharmacokinetic Analysis of the Oral Absorption Process of Tacrolimus in Healthy Volunteers . Kor J Clin Pharmacol Ther. 2007; 15(2):117-126. Hong EU, Savic RM and Yim DS. .
    80. Pharmacokinetics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults. J Clin Pharmacol. 2006 Oct; 46(10):1204-11. Osterberg O, Savic RM, Karlsson MO, Simonsson US, Nørgaard JP, Walle JV, Agersø H. PMID: 16988210.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    81. Application of population pharmacokinetics to cladribine. BMC Pharmacol. 2005 Mar 09; 5:4. Lindemalm S, Savic RM, Karlsson MO, Juliusson G, Liliemark J, Albertioni F. PMID: 15757511.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
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