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Joel Ernst, MD

TitleProfessor and Chief
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
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    Collapse Research 
    Collapse Research Activities and Funding
    Antigen export in M. tuberculosis evasion of CD4 T cells
    NIH/NIAID R01AI124471Jul 20, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Role of antigen-specific T cell responses in the control of TB
    NIH/NIAID U19AI111211Aug 11, 2014 - Jul 31, 2021
    Role: Co-Principal Investigator
    Epitope-specific T cell activation to complement TB immunity and vaccine efficacy
    NIH/NIAID R56AI105180Jul 15, 2014 - Jun 30, 2015
    Role: Principal Investigator
    Training Program in Immunology and Inflammation
    NIH/NIAID T32AI100853Jul 1, 2012 - Jun 30, 2022
    Role: Co-Principal Investigator
    Mycobacterium tuberculosis antigen diversity
    NIH/NIAID R01AI090928Jun 15, 2010 - May 31, 2015
    Role: Principal Investigator
    Mycobacterium tuberculosis evasion of CD4+ T cells in vivo
    NIH/NIAID R01AI084041Jan 15, 2010 - Dec 31, 2015
    Role: Principal Investigator
    Mycobacterium tuberculosis evasion of CD4+ T cells in vivo
    NIH/NIAID R56AI084041Jul 22, 2009 - Dec 31, 2009
    Role: Principal Investigator
    Type I Interferons in Immunity to Tuberculosis
    NIH/NIAID R01AI059667Feb 15, 2004 - Jan 31, 2010
    Role: Principal Investigator
    Tuberculosis Immunity: Essential Host Genes
    NIH/NIAID R03AI053074Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    Cellular and Bacterial Dynamics in Tuberculosis
    NIH/NIAID R01AI051242Dec 1, 2001 - Dec 31, 2019
    Role: Principal Investigator
    M. tuberculosis evasion of immune effector mechanisms
    NIH/NIAID R01AI046097Jun 1, 2000 - May 31, 2010
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF NEUTROPHIL SECRETION
    NIH/NHLBI R01HL056001Apr 25, 1996 - Mar 31, 2001
    Role: Principal Investigator
    MYCOBACTERIUM TUBERCULOSIS;INDUCED MACROPHAGE SIGNALLING
    NIH/NHLBI R01HL051992Sep 30, 1993 - Aug 31, 2003
    Role: Co-Principal Investigator
    ROLE OF SYNEXIN IN LEUKOCYTE DEGRANULATION
    NIH/NIAID R29AI023697Jul 1, 1986 - Jun 30, 1991
    Role: Principal Investigator
    ROLE OF SYNEXIN IN LEUKOCYTE DEGRANULATION
    NIH/NIAID R23AI023697Jul 1, 1986 - Jun 30, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ernst J. Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis. Am J Respir Crit Care Med. 2018 Mar 15; 197(6):706-707. PMID: 29262261.
      View in: PubMed
    2. Ernst J, Cornelius A, Desvignes L, Tavs J, Norris BA. Limited antimycobacterial efficacy of epitope peptide administration despite enhanced antigen-specific CD4 T cell activation. J Infect Dis. 2018 Mar 14. PMID: 29548008.
      View in: PubMed
    3. Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, Mulligan MJ, Oladele A, Kaushal D, Cain KP, Waller L, Blumberg HM, Altman JD, Ernst J, Rengarajan J, Day CL. A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection. J Immunol. 2018 Apr 15; 200(8):3008-3019. PMID: 29540577.
      View in: PubMed
    4. Bolz M, Ernst J. Fishing for Answers in Human Mycobacterial Infections. Immunity. 2017 09 19; 47(3):395-397. PMID: 28930653.
      View in: PubMed
    5. Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst J, Porcelli SA, Maeurer M, Kornfeld H. "The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report. Vaccine. 2017 06 14; 35(27):3433-3440. PMID: 28476627.
      View in: PubMed
    6. Arlehamn CS, Copin R, Leary S, Mack SJ, Phillips E, Mallal S, Sette A, Blatner G, Siefers H, Ernst J. Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya. Hum Immunol. 2017 Apr; 78(4):325-326. PMID: 28315719.
      View in: PubMed
    7. Ernst J. Antigenic Variation and Immune Escape in the MTBC. Adv Exp Med Biol. 2017; 1019:171-190. PMID: 29116635.
      View in: PubMed
    8. Copin R, Wang X, Louie E, Escuyer V, Coscolla M, Gagneux S, Palmer GH, Ernst J. Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity. PLoS Pathog. 2016 Dec; 12(12):e1006111. PMID: 27973588.
      View in: PubMed
    9. Wiens KE, Ernst J. Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection. J Infect Dis. 2016 Dec 15; 214(12):1893-1896. PMID: 27803172.
      View in: PubMed
    10. Blumberg HM, Ernst J. The Challenge of Latent TB Infection. JAMA. 2016 Sep 06; 316(9):931-3. PMID: 27599327.
      View in: PubMed
    11. Wiens KE, Ernst J. The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent. PLoS Pathog. 2016 Aug; 12(8):e1005809. PMID: 27500737.
      View in: PubMed
    12. Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst J, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A. A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans. PLoS Pathog. 2016 Jul; 12(7):e1005760. PMID: 27409590; PMCID: PMC4943605.
    13. Srivastava S, Grace PS, Ernst J. Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis. Cell Host Microbe. 2016 Jan 13; 19(1):44-54. PMID: 26764596.
      View in: PubMed
    14. Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst J, Banaei N. Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis. PLoS Pathog. 2015 Dec; 11(12):e1005336. PMID: 26650245.
      View in: PubMed
    15. Grace PS, Ernst J. Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo. J Immunol. 2016 Jan 01; 196(1):357-64. PMID: 26573837.
      View in: PubMed
    16. Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst J, Gagneux S. M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens. Cell Host Microbe. 2015 Nov 11; 18(5):538-48. PMID: 26607161.
      View in: PubMed
    17. Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst J, Feske S. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. J Clin Invest. 2015 Jun; 125(6):2347-62. PMID: 25938788; PMCID: PMC4518689.
    18. Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst J, Bishai WR, Snider BB, Moody DB. In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection. Chem Biol. 2015 Apr 23; 22(4):516-526. PMID: 25910243; PMCID: PMC4432472.
    19. Srivastava S, Ernst J, Desvignes L. Beyond macrophages: the diversity of mononuclear cells in tuberculosis. Immunol Rev. 2014 Nov; 262(1):179-92. PMID: 25319335.
      View in: PubMed
    20. Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst J, Banaei N. LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathog. 2014 Sep; 10(9):e1004376. PMID: 25232742.
      View in: PubMed
    21. Copin R, Coscollá M, Efstathiadis E, Gagneux S, Ernst J. Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG). Vaccine. 2014 Oct 14; 32(45):5998-6004. PMID: 25211768.
      View in: PubMed
    22. Srivastava S, Ernst J. Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming. Cell Host Microbe. 2014 Jun 11; 15(6):741-52. PMID: 24922576.
      View in: PubMed
    23. Copin R, Coscollá M, Seiffert SN, Bothamley G, Sutherland J, Mbayo G, Gagneux S, Ernst J. Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition. MBio. 2014 Jan 14; 5(1):e00960-13. PMID: 24425732.
      View in: PubMed
    24. Wiens KE, Swaminathan H, Copin R, Lun DS, Ernst J. Equivalent T cell epitope promiscuity in ecologically diverse human pathogens. PLoS One. 2013; 8(8):e73124. PMID: 23951341.
      View in: PubMed
    25. Srivastava S, Ernst J. Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo. J Immunol. 2013 Aug 01; 191(3):1016-20. PMID: 23817429.
      View in: PubMed
    26. Desvignes LP, Ernst J. Taking sides: interferons in leprosy. Cell Host Microbe. 2013 Apr 17; 13(4):377-8. PMID: 23601100.
      View in: PubMed
    27. Fan L, Xiao HP, Hu ZY, Ernst J. Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects. PLoS One. 2012; 7(8):e42716. PMID: 22880090.
      View in: PubMed
    28. Bold TD, Ernst J. CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection. J Immunol. 2012 Sep 01; 189(5):2530-6. PMID: 22837486.
      View in: PubMed
    29. Ernst J. The immunological life cycle of tuberculosis. Nat Rev Immunol. 2012 Jul 13; 12(8):581-91. PMID: 22790178.
      View in: PubMed
    30. Ernst J, Hanekom W, Hawn T, Kampmann B, Rengarajan J. Meeting report: The International Conference on Human Immunity to Tuberculosis. Tuberculosis (Edinb). 2012 Sep; 92(5):440-4. PMID: 22658910.
      View in: PubMed
    31. Desvignes L, Wolf AJ, Ernst J. Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis. J Immunol. 2012 Jun 15; 188(12):6205-15. PMID: 22566567.
      View in: PubMed
    32. Bold TD, Davis DC, Penberthy KK, Cox LM, Ernst J, de Jong BC. Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6. J Infect Dis. 2012 Mar 15; 205(6):984-90. PMID: 22301632.
      View in: PubMed
    33. Blomgran R, Desvignes L, Briken V, Ernst J. Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells. Cell Host Microbe. 2012 Jan 19; 11(1):81-90. PMID: 22264515.
      View in: PubMed
    34. Philips JA, Ernst J. Tuberculosis pathogenesis and immunity. Annu Rev Pathol. 2012; 7:353-84. PMID: 22054143.
      View in: PubMed
    35. Bold TD, Banaei N, Wolf AJ, Ernst J. Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo. PLoS Pathog. 2011 May; 7(5):e1002063. PMID: 21637811.
      View in: PubMed
    36. Blomgran R, Ernst J. Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection. J Immunol. 2011 Jun 15; 186(12):7110-9. PMID: 21555529.
      View in: PubMed
    37. Kwan CK, Ernst J. HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev. 2011 Apr; 24(2):351-76. PMID: 21482729.
      View in: PubMed
    38. Philips JA, Ernst J. Directly observing therapy: a new view of drug tolerance in tuberculosis. Cell. 2011 Apr 01; 145(1):13-4. PMID: 21458661.
      View in: PubMed
    39. Comas I, Chakravartti J, Small PM, Galagan J, Niemann S, Kremer K, Ernst J, Gagneux S. Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat Genet. 2010 Jun; 42(6):498-503. PMID: 20495566.
      View in: PubMed
    40. Desvignes L, Ernst J. Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis. Immunity. 2009 Dec 18; 31(6):974-85. PMID: 20064452.
      View in: PubMed
    41. Olmos S, Stukes S, Ernst J. Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice. J Immunol. 2010 Jan 15; 184(2):895-901. PMID: 20007536.
      View in: PubMed
    42. Benson SA, Ernst J. TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms. PLoS One. 2009 Jul 24; 4(7):e6329. PMID: 19629181.
      View in: PubMed
    43. Banaei N, Kincaid EZ, Lin SY, Desmond E, Jacobs WR, Ernst J. Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green. Antimicrob Agents Chemother. 2009 Sep; 53(9):3799-802. PMID: 19596883.
      View in: PubMed
    44. Miller EA, Ernst J. Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed. J Clin Invest. 2009 May; 119(5):1079-82. PMID: 19422095.
      View in: PubMed
    45. Blumenthal A, Kobayashi T, Pierini LM, Banaei N, Ernst J, Miyake K, Ehrt S. RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Cell Host Microbe. 2009 Jan 22; 5(1):35-46. PMID: 19154986.
      View in: PubMed
    46. Bold TD, Ernst J. Who benefits from granulomas, mycobacteria or host? Cell. 2009 Jan 09; 136(1):17-9. PMID: 19135882.
      View in: PubMed
    47. Miller EA, Ernst J. Illuminating the black box of TNF action in tuberculous granulomas. Immunity. 2008 Aug 15; 29(2):175-7. PMID: 18701080.
      View in: PubMed
    48. Sinnis P, Ernst J. CO-opting the host HO-1 pathway in tuberculosis and malaria. Cell Host Microbe. 2008 May 15; 3(5):277-9. PMID: 18474353.
      View in: PubMed
    49. Wolf AJ, Desvignes L, Linas B, Banaiee N, Tamura T, Takatsu K, Ernst J. Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med. 2008 Jan 21; 205(1):105-15. PMID: 18158321.
      View in: PubMed
    50. Ernst J, Lewinsohn DM, Behar S, Blythe M, Schlesinger LS, Kornfeld H, Sette A. Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database. Tuberculosis (Edinb). 2008 Jul; 88(4):366-70. PMID: 18068490; PMCID: PMC2504685.
    51. Blythe MJ, Zhang Q, Vaughan K, de Castro R, Salimi N, Bui HH, Lewinsohn DM, Ernst J, Peters B, Sette A. An analysis of the epitope knowledge related to Mycobacteria. Immunome Res. 2007 Dec 14; 3:10. PMID: 18081934; PMCID: PMC2228276.
    52. Kincaid EZ, Wolf AJ, Desvignes L, Mahapatra S, Crick DC, Brennan PJ, Pavelka MS, Ernst J. Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo. J Immunol. 2007 Sep 01; 179(5):3187-95. PMID: 17709534.
      View in: PubMed
    53. Wolf AJ, Linas B, Trevejo-Nuñez GJ, Kincaid E, Tamura T, Takatsu K, Ernst J. Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J Immunol. 2007 Aug 15; 179(4):2509-19. PMID: 17675513.
      View in: PubMed
    54. Ernst J, Trevejo-Nuñez G, Banaiee N. Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis. J Clin Invest. 2007 Jul; 117(7):1738-45. PMID: 17607348.
      View in: PubMed
    55. Banaiee N, Jacobs WR, Ernst J. LspA-independent action of globomycin on Mycobacterium tuberculosis. J Antimicrob Chemother. 2007 Aug; 60(2):414-6. PMID: 17579235.
      View in: PubMed
    56. Banaiee N, Kincaid EZ, Buchwald U, Jacobs WR, Ernst J. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. J Immunol. 2006 Mar 01; 176(5):3019-27. PMID: 16493060.
      View in: PubMed
    57. Rosales JL, Ernst J, Hallows J, Lee KY. GTP-dependent secretion from neutrophils is regulated by Cdk5. J Biol Chem. 2004 Dec 24; 279(52):53932-6. PMID: 15492003.
      View in: PubMed
    58. Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst J, Charo IF. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol. 2004 Jun 15; 172(12):7647-53. PMID: 15187146.
      View in: PubMed
    59. Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst J. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. J Immunol. 2004 May 15; 172(10):6272-80. PMID: 15128816.
      View in: PubMed
    60. Nagabhushanam V, Solache A, Ting LM, Escaron CJ, Zhang JY, Ernst J. Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. J Immunol. 2003 Nov 01; 171(9):4750-7. PMID: 14568951.
      View in: PubMed
    61. Kincaid EZ, Ernst J. Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function. J Immunol. 2003 Aug 15; 171(4):2042-9. PMID: 12902509.
      View in: PubMed
    62. Peters W, Ernst J. Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis. Microbes Infect. 2003 Feb; 5(2):151-8. PMID: 12650773.
      View in: PubMed