Christina Theodoris, MD, PhD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Phone--
ORCID ORCID Icon0000-0003-1658-1447 Additional info
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    California Institute of Technology, Pasadena, CABS06/2009Biology
    University of California, San Francisco, San Francisco, CAMD, PhD06/2017Developmental and Stem Cell Biology
    Boston Children's Hospital, Boston, MA06/2022Pediatrics-Medical Genetics Residency

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    Our lab leverages cutting-edge machine learning and experimental genomics to map the gene regulatory networks disrupted in cardiovascular disease and discover network-correcting therapeutics. We develop machine learning models that leverage the unprecedented volume of transcriptomic and epigenomic data now available to gain a fundamental understanding of network dynamics that can be democratized to a vast array of downstream applications. Investigating the consequences of network rewiring that occurs in disease states uncovers the key mechanisms that coordinate gene transcription to ensure normal development and tissue maintenance. Furthermore, mapping the network dysregulation driving disease allows targeting normalization of central elements to treat the core disease mechanism rather than merely managing symptoms. We apply an innovative network-based framework for therapeutic discovery to cardiovascular disease to accelerate development of much-needed treatments for patients as well as to advance our fundamental understanding of the regulatory circuitry governing human development and disease.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MIRA: joint regulatory modeling of multimodal expression and chromatin accessibility in single cells. Nat Methods. 2022 09; 19(9):1097-1108. Lynch AW, Theodoris CV, Long HW, Brown M, Liu XS, Meyer CA. PMID: 36068320; PMCID: PMC9517733.
      View in: PubMed   Mentions:
    2. Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease. Science. 2021 02 12; 371(6530). Theodoris CV, Zhou P, Liu L, Zhang Y, Nishino T, Huang Y, Kostina A, Ranade SS, Gifford CA, Uspenskiy V, Malashicheva A, Ding S, Srivastava D. PMID: 33303684; PMCID: PMC7880903.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    3. Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency. J Clin Invest. 2017 May 01; 127(5):1683-1688. Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D. PMID: 28346225; PMCID: PMC5409071.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    4. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 2016 08 17; 7(1):115. Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC. PMID: 27530160; PMCID: PMC4988052.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    5. NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. J Mol Cell Cardiol. 2015 Jul; 84:13-23. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D. PMID: 25871831; PMCID: PMC4468000.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    6. Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell. 2015 Mar 12; 160(6):1072-86. Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D. PMID: 25768904; PMCID: PMC4359747.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    7. A spatially dynamic cohort of regulatory genes in the endomesodermal gene network of the sea urchin embryo. Dev Biol. 2008 Jan 15; 313(2):863-75. Smith J, Kraemer E, Liu H, Theodoris C, Davidson E. PMID: 18061160; PMCID: PMC3640430.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    8. A gene regulatory network subcircuit drives a dynamic pattern of gene expression. Science. 2007 Nov 02; 318(5851):794-7. Smith J, Theodoris C, Davidson EH. PMID: 17975065.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
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