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Edward Hsiao, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-353-2350
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins UniversityM.D.2001School of Medicine

    Collapse Overview 
    Collapse Overview
    EDUCATION/CLINICAL TRAINING
    MD: MD, PhD, Johns Hopkins Medical School, 2001
    Residency: Johns Hopkins Hospital, Baltimore, MD, Internal Medicine, 2001-2004
    Fellowship: UCSF, Division of Diabetes, Endocrinology and Metabolism, 2004-2007
    Board Certifications: Internal Medicine, 2004; Endocrinology and Metabolism, 2006

    ACADEMIC INTERESTS
    My research is driven by a desire to understand how major hormonal and regulatory pathways determine the specification, differentiation, and morphogenesis of mesenchymal tissues such as bone, cartilage, muscle, and fat. Mis-regulation of these pathways leads to significant medical diseases, including the inappropriate formation of mineralized tissues in atherosclerosis, heterotopic ossification, and cancer.

    My research focuses on understanding how these regulatory signals control normal and pathologic tissue formation as a way to identifying new therapeutic avenues for treating human diseases. Our laboratory takes a comprehensive approach to understanding hormone signaling in human diseases using synthetic biology approaches, mouse models, and human stem cell models.

    By combining multiple approaches with state-of-the art methods, our laboratory is working to develop a broader understanding of the biology underlying skeletal development, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect important tissues such as fat, muscle, bone, cartilage, and blood vessels.

    CLINICAL INTERESTS:
    General Endocrinology with an interest in inherited skeletal diseases, including fibrous dysplasia of the bone (FD), McCune-Albright syndrome (MAS), and fibrodysplasia ossificans progressiva (FOP).

    Appointments: 415-353-2350
    Availability: General Endocrinology, 3rd Tuesday PM of each month

    Laboratory website: http://tiny.ucsf.edu/hsiaolab


    Collapse Research 
    Collapse Research Activities and Funding
    Innate immune regulation of stem cells in bone formation
    NIH/NIAMS R01AR066735Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    A New Regulator of Trabecular Bone Formation
    NIH/NIAMS R03AR060986Apr 1, 2011 - Jan 31, 2015
    Role: Principal Investigator
    Regulation of Bone Formation by G-protein Signaling
    NIH/NIAMS K08AR056299Jul 3, 2009 - Jun 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Clinical Trials
    Collapse Global Health
    Collapse Featured Videos
    Collapse Featured Publications
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Schmitt CE, Morales BM, Schmitz EMH, Hawkins JS, Lizama CO, Zape JP, Hsiao E, Zovein AC. Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming. Stem Cell Res Ther. 2017 Jun 05; 8(1):132. PMID: 28583172.
      View in: PubMed
    2. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao E, Klein OD, Pomerantz JH, Bush JO. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 Feb 22. PMID: 28238796.
      View in: PubMed
    3. Hayashi Y, Hsiao E, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):13057-13062. PMID: 27794120.
      View in: PubMed
    4. Hsiao E, Millard SM, Nissenson RA. Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors. Horm Metab Res. 2016 Nov; 48(11):689-699. PMID: 27643449.
      View in: PubMed
    5. Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao E. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 2016; 7(1):115. PMID: 27530160.
      View in: PubMed
    6. Wentworth K, Hsing A, Urrutia A, Zhu Y, Horvai AE, Bastepe M, Hsiao E. A Novel T55A Variant of Gs a Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis. Case Rep Endocrinol. 2016; 2016:2691385. PMID: 27579188; PMCID: PMC4992514.
    7. Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao E. Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization. Bone Rep. 2016 Dec; 5:86-95. PMID: 27453922.
      View in: PubMed
    8. Cain CJ, Valencia JT, Ho S, Jordan K, Mattingly A, Morales BM, Hsiao E. Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice. Endocrinology. 2016 Apr; 157(4):1481-94. PMID: 26901092.
      View in: PubMed
    9. Barruet E, Hsiao E. Using Human Induced Pluripotent Stem Cells to Model Skeletal Diseases. Methods Mol Biol. 2016; 1353:101-18. PMID: 25549831.
      View in: PubMed
    10. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao E. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9. PMID: 26253396.
      View in: PubMed
    11. Shah AD, Hsiao E, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6. PMID: 26097993; PMCID: PMC4524985 [Available on 08/01/16].
    12. Wang L, Hsiao E, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res. 2015 Oct; 30(10):1896-904. PMID: 25917236.
      View in: PubMed
    13. Hong CW, Hsiao E, Horvai AE, Link TM. Chronic recurrent multifocal osteomyelitis with an atypical presentation in an adult man. Skeletal Radiol. 2015 Sep; 44(9):1359-64. PMID: 25771734.
      View in: PubMed
    14. Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao E, Conklin BR, Nissenson RA. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Exp Cell Res. 2015 May 1; 333(2):289-302. PMID: 25704759; PMCID: PMC4408231 [Available on 05/01/16].
    15. Orr AG, Hsiao E, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015 Mar; 18(3):423-34. PMID: 25622143; PMCID: PMC4340760.
    16. Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao E. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014; 9(5):e94989. PMID: 24788917; PMCID: PMC4006800.
    17. Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao E, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM. Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK. J Bone Miner Res. 2014 Apr; 29(4):911-21. PMID: 24014458; PMCID: PMC4419358.
    18. Bershteyn M, Hayashi Y, Desachy G, Hsiao E, Sami S, Tsang KM, Weiss LA, Kriegstein AR, Yamanaka S, Wynshaw-Boris A. Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells. Nature. 2014 Mar 6; 507(7490):99-103. PMID: 24413397; PMCID: PMC4030630.
    19. Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao E. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet J Rare Dis. 2013; 8:190. PMID: 24321451; PMCID: PMC3892046.
    20. Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao E, Passegué E. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell. 2013 Sep 5; 13(3):285-99. PMID: 23850243; PMCID: PMC3769504.
    21. Spindler MJ, Burmeister BT, Huang Y, Hsiao E, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR. AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to ß-adrenergic-induced cardiac hypertrophy. PLoS One. 2013; 8(4):e62705. PMID: 23658642; PMCID: PMC3637253.
    22. Schepers K, Hsiao E, Garg T, Scott MJ, Passegué E. Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. Blood. 2012 Oct 25; 120(17):3425-35. PMID: 22859604; PMCID: PMC3482855.
    23. Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao E. Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int. 2011 Jul; 89(1):10-20. PMID: 21526395; PMCID: PMC3110278.
    24. Hsiao E, Nguyen TD, Ng JK, Scott MJ, Chang WC, Zahed H, Conklin BR. Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice. Stem Cell Res Ther. 2011; 2(2):11. PMID: 21375737; PMCID: PMC3226282.
    25. van Laake LW, Qian L, Cheng P, Huang Y, Hsiao E, Conklin BR, Srivastava D. Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circ Res. 2010 Aug 6; 107(3):340-7. PMID: 20558827; PMCID: PMC2919280.
    26. Hsiao E, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 2010 Mar; 25(3):584-93. PMID: 20200944; PMCID: PMC3153396.
    27. Hsiao E, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA. Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinol. 2010 Mar; 24(3):621-31. PMID: 20150184; PMCID: PMC2840804.
    28. Conklin BR, Hsiao E, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5(8):673-8. PMID: 18668035; PMCID: PMC2703467.
    29. Hsiao E, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin BR. Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter. PLoS One. 2008; 3(7):e2532. PMID: 18596956; PMCID: PMC2430532.
    30. Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao E, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2008 Mar 6; 2(3):219-29. PMID: 18371447; PMCID: PMC2293325.
    31. Hsiao E, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. PMID: 18212126; PMCID: PMC2234117.
    32. Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao E, Conklin BR. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor. PLoS One. 2007; 2(12):e1317. PMID: 18338032; PMCID: PMC2267039.
    33. Kwon C, Arnold J, Hsiao E, Taketo MM, Conklin BR, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10894-9. PMID: 17576928; PMCID: PMC1904134.
    34. Zimmers TA, Jin X, Hsiao E, Perez EA, Pierce RH, Chavin KD, Koniaris LG. Growth differentiation factor-15: induction in liver injury through p53 and tumor necrosis factor-independent mechanisms. J Surg Res. 2006 Jan; 130(1):45-51. PMID: 16154591.
      View in: PubMed
    35. Hsiao E, Charles R, Magid C, Nivatpumin P, Wiener CM. An unusual development. Am J Med. 2005 Jun; 118(6):609-11. PMID: 15922691.
      View in: PubMed
    36. Zimmers TA, Jin X, Hsiao E, McGrath SA, Esquela AF, Koniaris LG. Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury. Shock. 2005 Jun; 23(6):543-8. PMID: 15897808.
      View in: PubMed
    37. Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao E, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H, Ball DW. Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling. J Clin Endocrinol Metab. 2005 Jul; 90(7):4350-6. PMID: 15870121.
      View in: PubMed
    38. Maruthur NM, Hsiao E, Lee J, Nivatpumin P. Cases from the Osler medical service at Johns Hopkins University. Am J Med. 2004 Apr 1; 116(7):490-2. PMID: 15047040.
      View in: PubMed
    39. Koniaris LG, Zimmers-Koniaris T, Hsiao E, Chavin K, Sitzmann JV, Farber JM. Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. J Immunol. 2001 Jul 1; 167(1):399-406. PMID: 11418676.
      View in: PubMed
    40. Hsiao E, Koniaris LG, Zimmers-Koniaris T, Sebald SM, Huynh TV, Lee SJ. Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol. 2000 May; 20(10):3742-51. PMID: 10779363; PMCID: PMC85678.
    41. Hertel KJ, Lynch KW, Hsiao E, Liu EH, Maniatis T. Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements. RNA. 1996 Oct; 2(10):969-81. PMID: 8849774; PMCID: PMC1369430.
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