Edward Hsiao, MD, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-9732
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins UniversityM.D.2001School of Medicine
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    EDUCATION/CLINICAL TRAINING
    MD: MD, PhD, Johns Hopkins Medical School, 2001
    Residency: Johns Hopkins Hospital, Baltimore, MD, Internal Medicine, 2001-2004
    Fellowship: UCSF, Division of Diabetes, Endocrinology and Metabolism, 2004-2007
    Board Certifications: Internal Medicine, 2004; Endocrinology and Metabolism, 2006

    ACADEMIC INTERESTS
    My research is driven by a desire to understand how major hormonal and regulatory pathways determine the specification, differentiation, and morphogenesis of mesenchymal tissues such as bone, cartilage, muscle, and fat. Mis-regulation of these pathways leads to significant medical diseases, including the inappropriate formation of mineralized tissues in atherosclerosis, heterotopic ossification, and cancer.

    My research focuses on understanding how these regulatory signals control normal and pathologic tissue formation as a way to identifying new therapeutic avenues for treating human diseases. Our laboratory takes a comprehensive approach to understanding hormone signaling in human diseases using synthetic biology approaches, mouse models, and human stem cell models.

    By combining multiple approaches with state-of-the art methods, our laboratory is working to develop a broader understanding of the biology underlying skeletal development, devise novel therapeutic approaches for treating human skeletal disorders and bone injuries, and examine how hormone signals affect important tissues such as fat, muscle, bone, cartilage, and blood vessels.

    CLINICAL INTERESTS:
    General Endocrinology with an interest in inherited skeletal diseases, including fibrous dysplasia of the bone (FD), McCune-Albright syndrome (MAS), and fibrodysplasia ossificans progressiva (FOP).

    Appointments: 415-353-2350
    Availability: General Endocrinology, 3rd Tuesday PM of each month

    Laboratory website: http://tiny.ucsf.edu/hsiaolab

    Collapse Research 
    Collapse Research Activities and Funding
    Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus
    NIH UH3DK120004Sep 20, 2018 - Jul 31, 2023
    Role: Co-Principal Investigator
    Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus
    NIH UG3DK120004Sep 20, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    Pharmacologic modulation of innate immune dysfunction in heterotopic ossification
    NIH R01AR073015Sep 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Elucidating skeletal stem cell function using engineered 3D multicellular structures
    NIH R21AR072778Mar 13, 2018 - Jan 31, 2020
    Role: Principal Investigator
    Innate immune regulation of stem cells in bone formation
    NIH R01AR066735Sep 1, 2015 - Aug 31, 2021
    Role: Principal Investigator
    A New Regulator of Trabecular Bone Formation
    NIH R03AR060986Apr 1, 2011 - Jan 31, 2015
    Role: Principal Investigator
    Regulation of Bone Formation by G-protein Signaling
    NIH K08AR056299Jul 3, 2009 - Jun 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications
    Collapse Student Projects

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs. Med Educ Online. 2021 Dec; 26(1):1946237. Huppert LA, Hsu G, Elnachef N, Flint L, Frank JA, Gensler LS, Hsiao EC, Khanna RR, Qasim A, Schwartz BS, Widera E, Zapata C, Babik JM. PMID: 34187346.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    2. Re-defining the role of surgery in the management of patients with oligometastatic stage IV melanoma in the era of effective systemic therapies. Eur J Cancer. 2021 Jun 11; 153:8-15. Ch'ng S, Uyulmaz S, Carlino MS, Pennington TE, Shannon KF, Rtshiladze M, Stretch JR, Nieweg OE, Varey AHR, Hsiao E, Kapoor R, Pires da Silva I, Lo SN, Spillane AJ, Scolyer RA, Long GV, Hong AM, Saw RPM, Thompson JF, Menzies AM. PMID: 34126335.
      View in: PubMed   Mentions:    Fields:    
    3. Off-on-off-on use of imatinib in three children with fibrodysplasia ossificans progressiva. Bone. 2021 May 19; 150:116016. Kaplan FS, Teachey DT, Andolina JR, Siegel DM, Mancilla EE, Hsiao EC, Al Mukaddam M, Rocke DM, Pignolo RJ. PMID: 34022457.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Global Wnt Inhibition With a Porcupine Inhibitor Decreases Established Trabecular Bone in a Mouse Model of Fibrous Dysplasia. Journal of the Endocrine Society. 2021 May 3; 5(Suppl 1):a234-a234. Hsuan Lung, Tania Moody, Kelly Wentworth, Misun Kang, Sunita Ho, Edward Hsiao. .
      View in: Publisher Site   Mentions:
    5. Cardiopulmonary and Neurologic Dysfunctions in Fibrodysplasia Ossificans Progressiva. Biomedicines. 2021 Feb 05; 9(2). Khan F, Yu X, Hsiao EC. PMID: 33562570.
      View in: PubMed   Mentions:
    6. A Global Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes. Osteologie/Osteology. 2021 Feb 1; 30(01):73-73. M Al Mukaddam, C Stockklausner, RJ Pignolo, G Baujat, MA Brown, C De Cunto, M Di Rocco, EC Hsiao, R Keen, K-H Le Quan Sang, A Strahs, R Marino, FS Kaplan. .
      View in: Publisher Site   Mentions:
    7. Use of Assistive Devices and Adaptations by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study. Osteologie/Osteology. 2021 Feb 1; 30(01):75-75. EC Hsiao, JO Semler, M Al Mukaddam, G Baujat, C De Cunto, R Keen, RJ Pignolo, K Harnett, R Marino, FS Kaplan. .
      View in: Publisher Site   Mentions:
    8. Medications Used by Individuals with Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study. Osteologie/Osteology. 2021 Feb 1; 30(01):73-74. R Keen, C Stockklausner, M Al Mukaddam, G Baujat, C De Cunto, EC Hsiao, RJ Pignolo, K Harnett, R Marino, FS Kaplan. .
      View in: Publisher Site   Mentions:
    9. Longitudinal and Flare-Up-Specific Biomarkers in Fibrodysplasia Ossificans Progressiva (FOP): Data from a Global Natural History Study. Osteologie/Osteology. 2021 Feb 1; 30(01):75-76. RJ Pignolo, JO Semler, M Al Mukaddam, G Baujat, C De Cunto, EC Hsiao, R Keen, K Harnett, R Marino, FS Kaplan. .
      View in: Publisher Site   Mentions:
    10. Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices. Acad Med. 2020 Dec 08. Huppert LA, Hsiao EC, Cho KC, Marquez C, Chaudhry RI, Frank J, Goglin SE, Hsu G, Kathpalia P, Khanna R, Kompala T, Rao MN, Bower BA, Trafas V, Santhosh L, Schwartz BS, Babik JM. PMID: 33298691.
      View in: PubMed   Mentions: 2     Fields:    
    11. A natural history study of fibrodysplasia ossificans progressiva (FOP): 12-month outcome results. Bone Reports. 2020 Oct 1; 13:100607. Robert J. Pignolo, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Maja Di Rocco, Edward C. Hsiao, Richard Keen, Mona Al Mukaddam, Kim Hanh Le Quan Sang, Andrew Strahs, Rose Marino, Frederick S. Kaplan. .
      View in: Publisher Site   Mentions:
    12. Measuring outcomes in ultra-rare bone diseases: Methodology of the palovarotene fibrodysplasia ossificans progressiva clinical development programme. Bone Reports. 2020 Oct 1; 13:100609. Robert J. Pignolo, Geneviève Baujat, Matthew A. Brown, Carmen De Cunto, Maja Di Rocco, Edward C. Hsiao, Richard Keen, Mona Al Mukaddam, Andrew Strahs, Donna R. Grogan, Rose Marino, Frederick S. Kaplan. .
      View in: Publisher Site   Mentions:
    13. A global natural history study of Fibrodysplasia Ossificans Progressiva (FOP): 12-month outcomes. Endocrine Abstracts. 2020 Aug 21. Mona Al Mukaddam, Robert J. Pignolo, Geneviève Baujat, Matthew A Brown, Cunto Carmen De, Rocco Maja Di, Edward C. Hsiao, Richard Keen, Quan Sang Kim-Hanh Le, Andrew Strahs, Rose Marino, Frederick S Kaplan. .
      View in: Publisher Site   Mentions:
    14. Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva. Orphanet J Rare Dis. 2020 07 29; 15(1):193. Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC. PMID: 32727600.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. MON-348 Surgical Management of Bilateral Hip Fracture in a Patient with Fibrodysplasia Ossificans Progressiva Treated with Palovarotene. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Sukhmani Singh, Joseph Kidane, Kelly Lee Wentworth, Daria Motamedi, Saam Morshed, Edward Chiaming Hsiao. .
      View in: Publisher Site   Mentions:
    16. OR29-05 A Natural History Study of Fibrodysplasia Ossificans Progressiva (FOP): 12-Month Outcomes. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Mona Al Mukaddam, Robert J Pignolo, Geneviève Baujat, Matthew A Brown, Carmen De Cunto, Maja Di Rocco, Edward C Hsiao, Richard W Keen, Kim-Hanh Le Quan Sang, Andrew Strahs, Rose Marino, Frederick S Kaplan. .
      View in: Publisher Site   Mentions:
    17. MON-710 ACVR1 Activation in Primary and iPS-Derived Human Skeletal Muscle Stem Cells Impairs Myogenic Transcriptional Signature and Function. Journal of the Endocrine Society. 2020 May 8; 4(Supplement_1):mon-710-. Emilie Barruet, Steven Garcia, Stanley Tamaki, Blanca M Morales, Jake Wu, Tania Moody, Jason H Pomerantz, Edward Chiaming Hsiao. .
      View in: Publisher Site   Mentions:
    18. SUN-368 Wnt Inhibition Decreases Trabecular Bone in a Mouse Model of Fibrous Dysplasia. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Hsuan Lung, Kelly Wentworth, Tania Moody, Misun Kang, Sunita Ho, Edward Hsiao. .
      View in: Publisher Site   Mentions:
    19. SUN-344 Patients with Fibrodysplasia Ossificans Progressiva Have an Increased Prevalence of Cardiac Conduction Abnormalities. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Samuel Kou, Carmen DeCunto, Geneviève Baujat, Kelly Lee Wentworth, Donna Grogan, Matthew A Brown, Maja D Rocco, Richard Keen, Mona Al Mukaddam, Frederick S Kaplan, Robert J Pignolo, Edward Chiaming Hsiao. .
      View in: Publisher Site   Mentions:
    20. Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-? agonist palovarotene: a case report. BMC Musculoskelet Disord. 2020 Apr 03; 21(1):204. Singh S, Kidane J, Wentworth KL, Motamedi D, Morshed S, Schober AE, Hsiao EC. PMID: 32245464.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry. Bone. 2020 05; 134:115274. Pignolo RJ, Cheung K, Kile S, Fitzpatrick MA, De Cunto C, Al Mukaddam M, Hsiao EC, Baujat G, Delai P, Eekhoff EMW, Di Rocco M, Grunwald Z, Haga N, Keen R, Levi B, Morhart R, Scott C, Sherman A, Zhang K, Kaplan FS. PMID: 32062004.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome. Front Endocrinol (Lausanne). 2019; 10:925. Lung H, Hsiao EC, Wentworth KL. PMID: 32038487.
      View in: PubMed   Mentions:
    23. Inflammation in Fibrodysplasia Ossificans Progressiva and Other Forms of Heterotopic Ossification. Curr Osteoporos Rep. 2019 12; 17(6):387-394. Matsuo K, Chavez RD, Barruet E, Hsiao EC. PMID: 31721068.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Palovarotene inhibits the development of new heterotopic ossification in fibrodysplasia ossificans progressiva (FOP). Bone Abstracts. 2019 Jul 31. Frederick Kaplan, Edward C Hsiao, Genevieve Baujat, Richard Keen, Cunto Carmen De, Rocco Maja Di, Matthew A Brown, Mukaddam Mona M Al, Donna R Grogan, Robert J Pignolo. .
      View in: Publisher Site   Mentions:
    25. Correction to: Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes. Orphanet J Rare Dis. 2019 May 23; 14(1):113. Pignolo RJ, Baujat G, Brown MA, De Cunto C, Di Rocco M, Hsiao EC, Keen R, Al Mukaddam M, Sang KLQ, Wilson A, White B, Grogan DR, Kaplan FS. PMID: 31122250.
      View in: PubMed   Mentions:    Fields:    
    26. Natural history of fibrodysplasia ossificans progressiva: cross-sectional analysis of annotated baseline phenotypes. Orphanet J Rare Dis. 2019 05 03; 14(1):98. Pignolo RJ, Baujat G, Brown MA, De Cunto C, Di Rocco M, Hsiao EC, Keen R, Al Mukaddam M, Sang KLQ, Wilson A, White B, Grogan DR, Kaplan FS. PMID: 31053156.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures. J Tissue Eng Regen Med. 2019 03; 13(3):433-445. Pennings I, van Dijk LA, van Huuksloot J, Fledderus JO, Schepers K, Braat AK, Hsiao EC, Barruet E, Morales BM, Verhaar MC, Rosenberg AJWP, Gawlitta D. PMID: 30650247.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva. Br J Clin Pharmacol. 2019 06; 85(6):1180-1187. Wentworth KL, Masharani U, Hsiao EC. PMID: 30501012.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    29. NF-?B/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI Insight. 2018 11 15; 3(22). Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC. PMID: 30429363.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    30. Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP). Br J Clin Pharmacol. 2019 06; 85(6):1199-1207. Hsiao EC, Di Rocco M, Cali A, Zasloff M, Al Mukaddam M, Pignolo RJ, Grunwald Z, Netelenbos C, Keen R, Baujat G, Brown MA, Cho TJ, De Cunto C, Delai P, Haga N, Morhart R, Scott C, Zhang K, Diecidue RJ, Friedman CS, Kaplan FS, Eekhoff EMW. PMID: 30281842.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    31. Fibrodysplasia ossificans progressiva: a current review of imaging findings. Skeletal Radiol. 2018 Aug; 47(8):1043-1050. Bauer AH, Bonham J, Gutierrez L, Hsiao EC, Motamedi D. PMID: 29445932.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Utilizing 18F-fluoroethyltyrosine (FET) positron emission tomography (PET) to define suspected nonenhancing tumor for radiation therapy planning of glioblastoma. Pract Radiat Oncol. 2018 Jul - Aug; 8(4):230-238. Hayes AR, Jayamanne D, Hsiao E, Schembri GP, Bailey DL, Roach PJ, Khasraw M, Newey A, Wheeler HR, Back M. PMID: 29730279.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    33. Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva. Bone. 2018 04; 109:104-110. Wentworth KL, Bigay K, Chan TV, Ho JP, Morales BM, Connor J, Brooks E, Shahriar Salamat M, Sanchez HC, Wool G, Pignolo RJ, Kaplan FS, Hsiao EC. PMID: 29033382.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    34. The FOP Connection Registry: Design of an international patient-sponsored registry for Fibrodysplasia Ossificans Progressiva. Bone. 2018 04; 109:285-290. Mantick N, Bachman E, Baujat G, Brown M, Collins O, De Cunto C, Delai P, Eekhoff M, Zum Felde R, Grogan DR, Haga N, Hsiao E, Kantanie S, Kaplan F, Keen R, Milosevic J, Morhart R, Pignolo R, Qian X, di Rocco M, Scott C, Sherman A, Wallace M, Williams N, Zhang K, Bogard B. PMID: 28866367.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    35. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. PMID: 28911171.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Early clinical observations on the use of imatinib mesylate in FOP: A report of seven cases. Bone. 2018 04; 109:276-280. Kaplan FS, Andolina JR, Adamson PC, Teachey DT, Finklestein JZ, Ebb DH, Whitehead B, Jacobs B, Siegel DM, Keen R, Hsiao E, Pignolo RJ. PMID: 28736245.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    37. Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva. Bone. 2018 04; 109:162-167. Barruet E, Hsiao EC. PMID: 28716551.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    38. Fibrodysplasia ossificans progressiva: baseline characteristics of 101 subjects participating in a global, longitudinal, natural history study. Bone Abstracts. 2017 Jul 11. Frederick S Kaplan, Edward C Hsiao, Genevieve Baujat, Matthew A Brown, Cunto Carmen De, Rocco Maja Di, Richard Keen, Makkadam Mona Al, Donna R Grogan, Robert J Pignolo. .
      View in: Publisher Site   Mentions:
    39. International physician survey on management of FOP: a modified Delphi study. Orphanet J Rare Dis. 2017 06 12; 12(1):110. Di Rocco M, Baujat G, Bertamino M, Brown M, De Cunto CL, Delai PLR, Eekhoff EMW, Haga N, Hsiao E, Keen R, Morhart R, Pignolo RJ, Kaplan FS. PMID: 28606101.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming. Stem Cell Res Ther. 2017 06 05; 8(1):132. Schmitt CE, Morales BM, Schmitz EMH, Hawkins JS, Lizama CO, Zape JP, Hsiao EC, Zovein AC. PMID: 28583172.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    41. Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: Proposal for a Novel Grading Scheme with Prognostic Significance. Theranostics. 2017; 7(5):1149-1158. Chan DL, Pavlakis N, Schembri GP, Bernard EJ, Hsiao E, Hayes A, Barnes T, Diakos C, Khasraw M, Samra J, Eslick E, Roach PJ, Engel A, Clarke SJ, Bailey DL. PMID: 28435454.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    42. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 03 14; 8(3):529-537. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. PMID: 28238796.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. The Rare Bone Disease Working Group: report from the 2016 American Society for Bone and Mineral Research Annual Meeting. Bone. 2017 Sep; 102:80-84. Drake MT, Collins MT, Hsiao EC. PMID: 28115283.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    44. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13057-13062. Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S. PMID: 27794120.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    45. Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors. Horm Metab Res. 2016 Nov; 48(11):689-699. Hsiao EC, Millard SM, Nissenson RA. PMID: 27643449.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    46. The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling. Stem Cell Res Ther. 2016 08 17; 7(1):115. Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC. PMID: 27530160.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    47. A Novel T55A Variant of Gs a Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis. Case Rep Endocrinol. 2016; 2016:2691385. Wentworth K, Hsing A, Urrutia A, Zhu Y, Horvai AE, Bastepe M, Hsiao EC. PMID: 27579188.
      View in: PubMed   Mentions:
    48. Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization. Bone Rep. 2016 Dec; 5:86-95. Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC. PMID: 27453922.
      View in: PubMed   Mentions:
    49. Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice. Endocrinology. 2016 Apr; 157(4):1481-94. Cain CJ, Valencia JT, Ho S, Jordan K, Mattingly A, Morales BM, Hsiao EC. PMID: 26901092.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    50. A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9. Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. PMID: 26253396.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    51. Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations. J Clin Endocrinol Metab. 2015 Aug; 100(8):2832-6. Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I. PMID: 26097993.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    52. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res. 2015 Oct; 30(10):1896-904. Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA. PMID: 25917236.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    53. Chronic recurrent multifocal osteomyelitis with an atypical presentation in an adult man. Skeletal Radiol. 2015 Sep; 44(9):1359-64. Hong CW, Hsiao EC, Horvai AE, Link TM. PMID: 25771734.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    54. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Exp Cell Res. 2015 May 01; 333(2):289-302. Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA. PMID: 25704759.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    55. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015 Mar; 18(3):423-34. Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. PMID: 25622143.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    56. Phocine distemper virus: current knowledge and future directions. Viruses. 2014 Dec 22; 6(12):5093-134. Duignan PJ, Van Bressem MF, Baker JD, Barbieri M, Colegrove KM, De Guise S, de Swart RL, Di Guardo G, Dobson A, Duprex WP, Early G, Fauquier D, Goldstein T, Goodman SJ, Grenfell B, Groch KR, Gulland F, Hall A, Jensen BA, Lamy K, Matassa K, Mazzariol S, Morris SE, Nielsen O, Rotstein D, Rowles TK, Saliki JT, Siebert U, Waltzek T, Wellehan JF. PMID: 25549831.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    57. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014; 9(5):e94989. Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC. PMID: 24788917.
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