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Benoit Bruneau, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPediatrics
Address1650 Owens St
San Francisco CA 94107
Phone415-734-2708
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    The main focus of our lab is to understand how a heart becomes a heart: what cell lineage decisions take place to direct cardiac differentiation, and what morphogenetic and patterning processes occur to assemble all of the heart's components into a functional organ. We are primarily interested in regulation of these processes by transcriptional regulatory mechanisms that include DNA-binding transcription factors, chromatin remodeling complexes, and histone modifications. We have used this knowledge to understand disease mechanisms, but also to devise strategies for cardiac regeneration.

    Why study heart development? We believe that primary defects in patterning in early heart development are at the root of congenital heart defects, which affect approximately 1% of live-born children, and we want to understand how these defects occur, to perhaps be able to uncover new and improved diagnostic or even therapeutic options. Also, by understanding how cardiac lineage specification occurs, we can better design stem cell-based interventions of cardiac repair, based on the knowledge of what drives an uncommitted cell towards a specific cardiac fate. We have recently focused our efforts on cardiac chromatin remodeling and modification factors, enzymes that unwind DNA or modify histones to turn genes on or off. We are particularly interested in how these factors control cardiac cell lineage decisions. These chromatin remodeling factors may also be key to pushing a stem cell into becoming a heart cell, perhaps opening up new avenues for cardiac regenerative medicine.


    Collapse Research 
    Collapse Research Activities and Funding
    Early Cardiac Progenitors
    NIH/NHLBI R01HL114948Jul 1, 2013 - Mar 31, 2021
    Role: Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI UM1HL098179Sep 30, 2009 - Jul 31, 2020
    Role: Principal Investigator
    Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart Diseas
    NIH/NHLBI U01HL100406Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI U01HL098179Sep 30, 2009 - Aug 31, 2015
    Role: Principal Investigator
    Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    NIH/NHLBI R01HL093414Jul 1, 2009 - Aug 30, 2011
    Role: Principal Investigator
    Induced pluripotent stem cells in the understanding and treatment of heart diseas
    NIH/NHLBI R03HL096254Dec 1, 2008 - May 31, 2009
    Role: Co-Principal Investigator
    Chromatin remodeling complexes in heart development
    NIH/NHLBI R01HL085860Sep 1, 2006 - Jun 30, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Yuan X, Song M, Devine P, Bruneau BG, Scott IC, Wilson MD. Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. Nat Commun. 2018 Nov 26; 9(1):4977. PMID: 30478328.
      View in: PubMed
    2. Bruneau BG, Nora EP. Chromatin Domains Go on Repeat in Disease. Cell. 2018 Sep 20; 175(1):38-40. PMID: 30241613.
      View in: PubMed
    3. Herman AM, Rhyner AM, Devine WP, Marrelli SP, Bruneau BG, Wythe JD. A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open. 2018 Feb 08. PMID: 29437553.
      View in: PubMed
    4. Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG. Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. Biol Open. 2018 Jan 05; 7(1). PMID: 29183906.
      View in: PubMed
    5. Nora EP, Goloborodko A, Valton AL, Gibcus JH, Uebersohn A, Abdennur N, Dekker J, Mirny LA, Bruneau BG. Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization. Cell. 2017 May 18; 169(5):930-944.e22. PMID: 28525758.
      View in: PubMed
    6. Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL. Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites. Development. 2017 04 01; 144(7):1235-1241. PMID: 28351867.
      View in: PubMed
    7. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. PMID: 27840107.
      View in: PubMed
    8. Hota SK, Bruneau BG. ATP-dependent chromatin remodeling during mammalian development. Development. 2016 08 15; 143(16):2882-97. PMID: 27531948; PMCID: PMC5004879 [Available on 08/15/17].
    9. Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC. Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization. Bone Rep. 2016 Dec; 5:86-95. PMID: 27453922; PMCID: PMC4926823 [Available on 12/01/17].
    10. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell. 2016 Mar 03; 18(3):368-81. PMID: 26942852.
      View in: PubMed
    11. Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG. KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 01; 143(5):810-21. PMID: 26932671; PMCID: PMC4813342.
    12. Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG. Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell. 2016 Feb 25; 164(5):999-1014. PMID: 26875865; PMCID: PMC4769693 [Available on 02/25/17].
    13. Holloway AK, Bruneau BG, Sukonnik T, Rubenstein JL, Pollard KS. Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor. Mol Biol Evol. 2016 Apr; 33(4):1008-18. PMID: 26715627.
      View in: PubMed
    14. Morey L, Santanach A, Blanco E, Aloia L, Nora EP, Bruneau BG, Di Croce L. Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms. Cell Stem Cell. 2015 Sep 03; 17(3):300-15. PMID: 26340528.
      View in: PubMed
    15. Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau BG. Brg1 modulates enhancer activation in mesoderm lineage commitment. Development. 2015 Apr 15; 142(8):1418-30. PMID: 25813539; PMCID: PMC4392595.
    16. Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D. Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell. 2015 Mar 12; 160(6):1072-86. PMID: 25768904; PMCID: PMC4359747.
    17. Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA. Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. BMC Evol Biol. 2015 Mar 10; 15:35. PMID: 25887984; PMCID: PMC4362643.
    18. Kathiriya IS, Nora EP, Bruneau BG. Investigating the transcriptional control of cardiovascular development. Circ Res. 2015 Feb 13; 116(4):700-14. PMID: 25677518; PMCID: PMC4332409.
    19. Pourquié O, Bruneau B, Keller G, Smith A. Looking inwards: opening a window onto human development. Development. 2015 Jan 01; 142(1):1-2. PMID: 25516961.
      View in: PubMed
    20. Delgado-Olguín P, Dang LT, He D, Thomas S, Chi L, Sukonnik T, Khyzha N, Dobenecker MW, Fish JE, Bruneau BG. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014 Dec; 141(23):4610-7. PMID: 25359725; PMCID: PMC4302930.
    21. Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG. Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife. 2014 Oct 08; 3. PMID: 25296024; PMCID: PMC4356145.
    22. Bruneau BG. Finding a niche for cardiac precursors. Elife. 2014 May 06; 3:e02993. PMID: 24843033; PMCID: PMC4007203.
    23. Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau BG, Mercola M, Minucci S, Puri PL. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Dev. 2014 Apr 15; 28(8):841-57. PMID: 24682306; PMCID: PMC4003277.
    24. Dickel DE, Zhu Y, Nord AS, Wylie JN, Akiyama JA, Afzal V, Plajzer-Frick I, Kirkpatrick A, Göttgens B, Bruneau BG, Visel A, Pennacchio LA. Function-based identification of mammalian enhancers using site-specific integration. Nat Methods. 2014 May; 11(5):566-71. PMID: 24658141; PMCID: PMC4008384.
    25. Bruneau BG, Srivastava D. Congenital heart disease: entering a new era of human genetics. Circ Res. 2014 Feb 14; 114(4):598-9. PMID: 24526674.
      View in: PubMed
    26. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. PMID: 24207025; PMCID: PMC3936344.
    27. Bruneau B. An interview with Benoit Bruneau. Development. 2013 Nov; 140(22):4463-4. PMID: 24194468.
      View in: PubMed
    28. Luna-Zurita L, Bruneau BG. Chromatin modulators as facilitating factors in cellular reprogramming. Curr Opin Genet Dev. 2013 Oct; 23(5):556-61. PMID: 23993229.
      View in: PubMed
    29. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47. PMID: 24319660; PMCID: PMC3849259.
    30. Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013; 9(7):e1003612. PMID: 23874215; PMCID: PMC3708807.
    31. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE. ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013 Jul 15; 26(1):45-58. PMID: 23830865; PMCID: PMC3754838.
    32. Pourquié O, Bruneau B, Götz M, Keller G, Smith A. Stem cells and regeneration: a special issue. Development. 2013 Jun; 140(12):2445. PMID: 23715535.
      View in: PubMed
    33. Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AP, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013 Mar 28; 14(3):R28. PMID: 23537068; PMCID: PMC4054807.
    34. Bruneau BG. Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol. 2013 Mar 01; 5(3):a008292. PMID: 23457256; PMCID: PMC3578359.
    35. Star EN, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL. Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec; 139(24):4644-55. PMID: 23172916; PMCID: PMC3509726.
    36. Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG. Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development. 2012 Nov; 139(21):4007-19. PMID: 22992950; PMCID: PMC3472592.
    37. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell. 2012 Sep 28; 151(1):206-20. PMID: 22981692; PMCID: PMC3462286.
    38. Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH. Iroquois homeodomain transcription factors in heart development and function. Circ Res. 2012 May 25; 110(11):1513-24. PMID: 22628575.
      View in: PubMed
    39. Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012 Jan 22; 44(3):343-7. PMID: 22267199; PMCID: PMC3288669.
    40. Chang CP, Bruneau BG. Epigenetics and cardiovascular development. Annu Rev Physiol. 2012; 74:41-68. PMID: 22035349.
      View in: PubMed
    41. Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13576-81. PMID: 21825130; PMCID: PMC3158173.
    42. Bruneau BG. Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis. Can J Physiol Pharmacol. 2011 Aug; 89(8):533-7. PMID: 21806510.
      View in: PubMed
    43. Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S. Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development. 2011 Sep; 138(17):3759-67. PMID: 21795281.
      View in: PubMed
    44. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 2011 Jun 27; 193(7):1181-96. PMID: 21690310; PMCID: PMC3216339.
    45. Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development. 2011 Apr; 138(7):1409-19. PMID: 21385766; PMCID: PMC3050667.
    46. Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguín P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG. Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun. 2011 Feb 08; 2:187. PMID: 21304516; PMCID: PMC3096875.
    47. Delgado-Olguín P, Brand-Arzamendi K, Scott IC, Jungblut B, Stainier DY, Bruneau BG, Recillas-Targa F. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011 Apr 08; 286(14):12483-94. PMID: 21288905; PMCID: PMC3069451.
    48. Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M. An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19356-61. PMID: 20974940; PMCID: PMC2984205.
    49. Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H, Rappold G. Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Hum Mol Genet. 2010 Dec 01; 19(23):4625-33. PMID: 20858598; PMCID: PMC2972695.
    50. Bruneau BG. Chromatin remodeling in heart development. Curr Opin Genet Dev. 2010 Oct; 20(5):505-11. PMID: 20702085.
      View in: PubMed
    51. Bruneau BG. Epigenetic regulation of the cardiovascular system: introduction to a review series. Circ Res. 2010 Aug 06; 107(3):324-6. PMID: 20689071; PMCID: PMC2930886.
    52. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 06; 142(3):375-86. PMID: 20691899; PMCID: PMC2919844.
    53. Alexander JM, Bruneau BG. Lessons for cardiac regeneration and repair through development. Trends Mol Med. 2010 Sep; 16(9):426-34. PMID: 20692205; PMCID: PMC3089764.
    54. Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet. 2010 May 01; 19(9):1633-50. PMID: 20106867; PMCID: PMC2850613.
    55. Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D. The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010 Feb 26; 285(9):6770-80. PMID: 20026598; PMCID: PMC2825471.
    56. Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG. Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 03; 461(7260):95-8. PMID: 19727199; PMCID: PMC2753965.
    57. Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS. NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. PLoS One. 2009 May 28; 4(5):e5698. PMID: 19479054; PMCID: PMC2684637.
    58. Takeuchi JK, Bruneau BG. Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature. 2009 Jun 04; 459(7247):708-11. PMID: 19396158; PMCID: PMC2728356.
    59. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 06; 4(3):198-9; author reply 202. PMID: 19265656.
      View in: PubMed
    60. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug; 15(2):272-84. PMID: 18694566; PMCID: PMC2604134.
    61. Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG. Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5519-24. PMID: 18378906; PMCID: PMC2291114.
    62. Bruneau BG. The developmental genetics of congenital heart disease. Nature. 2008 Feb 21; 451(7181):943-8. PMID: 18288184.
      View in: PubMed
    63. Feintuch A, Zhu Y, Bishop J, Davidson L, Dazai J, Bruneau BG, Henkelman RM. 4D cardiac MRI in the mouse. NMR Biomed. 2007 May; 20(3):360-5. PMID: 17451168.
      View in: PubMed
    64. Bruneau BG, Black BL. The heart's Da Vinci code: a Renaissance at Keystone. Development. 2007 May; 134(9):1631-3. PMID: 17395645.
      View in: PubMed
    65. Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG. Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):846-51. PMID: 17210915; PMCID: PMC1783402.
    66. Takeuchi JK, Bruneau BG. Irxl1, a divergent Iroquois homeobox family transcription factor gene. Gene Expr Patterns. 2007 Jan; 7(1-2):51-6. PMID: 16824806.
      View in: PubMed
    67. Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol. 2006 Sep 15; 297(2):566-86. PMID: 16870172.
      View in: PubMed
    68. Delgado-Olguín P, Takeuchi JK, Bruneau BG. Chromatin modification and remodeling in heart development. ScientificWorldJournal. 2006 Apr 24; 6:1851-61. PMID: 17205192.
      View in: PubMed
    69. Bruneau BG. [Irx5: a transcription factor that regulates the cardiac repolarization gradient]. Med Sci (Paris). 2006 Mar; 22(3):231-2. PMID: 16527195.
      View in: PubMed
    70. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006 Feb; 38(2):175-83. PMID: 16380715.
      View in: PubMed
    71. Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005 Oct 21; 123(2):347-58. PMID: 16239150; PMCID: PMC1480411.
    72. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005 Oct; 132(19):4375-86. PMID: 16155213.
      View in: PubMed
    73. Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR, Cheng SH. The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development. Dev Biol. 2005 Nov 01; 287(1):48-60. PMID: 16182275.
      View in: PubMed
    74. Frey BJ, Mohammad N, Morris QD, Zhang W, Robinson MD, Mnaimneh S, Chang R, Pan Q, Sat E, Rossant J, Bruneau BG, Aubin JE, Blencowe BJ, Hughes TR. Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet. 2005 Sep; 37(9):991-6. PMID: 16127451.
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    75. Bruneau BG. Developmental biology: tiny brakes for a growing heart. Nature. 2005 Jul 14; 436(7048):181-2. PMID: 16015310.
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    76. Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG. Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum. Mol Cell Biol. 2005 Jun; 25(12):5073-83. PMID: 15923624; PMCID: PMC1140596.
    77. Zhou YQ, Zhu Y, Bishop J, Davidson L, Henkelman RM, Bruneau BG, Foster FS. Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H992-H1001. PMID: 15849237.
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