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Benoit Bruneau, PhD

Address1650 Owens St
San Francisco CA 94107
Phone415-734-2708
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    Collapse Overview 
    Collapse Overview
    The main focus of our lab is to understand how a heart becomes a heart: what cell lineage decisions take place to direct cardiac differentiation, and what morphogenetic and patterning processes occur to assemble all of the heart's components into a functional organ. We are primarily interested in regulation of these processes by transcriptional regulatory mechanisms that include DNA-binding transcription factors, chromatin remodeling complexes, and histone modifications. We have used this knowledge to understand disease mechanisms, but also to devise strategies for cardiac regeneration.

    Why study heart development? We believe that primary defects in patterning in early heart development are at the root of congenital heart defects, which affect approximately 1% of live-born children, and we want to understand how these defects occur, to perhaps be able to uncover new and improved diagnostic or even therapeutic options. Also, by understanding how cardiac lineage specification occurs, we can better design stem cell-based interventions of cardiac repair, based on the knowledge of what drives an uncommitted cell towards a specific cardiac fate. We have recently focused our efforts on cardiac chromatin remodeling and modification factors, enzymes that unwind DNA or modify histones to turn genes on or off. We are particularly interested in how these factors control cardiac cell lineage decisions. These chromatin remodeling factors may also be key to pushing a stem cell into becoming a heart cell, perhaps opening up new avenues for cardiac regenerative medicine.


    Collapse Research 
    Collapse Research Activities and Funding
    Early Cardiac Progenitors
    NIH/NHLBI R01HL114948Jul 1, 2013 - Mar 31, 2021
    Role: Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI UM1HL098179Sep 30, 2009 - Jul 31, 2020
    Role: Principal Investigator
    Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart Diseas
    NIH/NHLBI U01HL100406Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI U01HL098179Sep 30, 2009 - Aug 31, 2015
    Role: Principal Investigator
    Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    NIH/NHLBI R01HL093414Jul 1, 2009 - Aug 30, 2011
    Role: Principal Investigator
    Induced pluripotent stem cells in the understanding and treatment of heart diseas
    NIH/NHLBI R03HL096254Dec 1, 2008 - May 31, 2009
    Role: Co-Principal Investigator
    Chromatin remodeling complexes in heart development
    NIH/NHLBI R01HL085860Sep 1, 2006 - Jun 30, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau B, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 Nov 9. PMID: 27840107.
      View in: PubMed
    2. Hota SK, Bruneau B. ATP-dependent chromatin remodeling during mammalian development. Development. 2016 Aug 15; 143(16):2882-97. PMID: 27531948.
      View in: PubMed
    3. Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau B, Hsiao EC. Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization. Bone Rep. 2016 Dec; 5:86-95. PMID: 27453922.
      View in: PubMed
    4. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau B, Srivastava D, Ding S. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell. 2016 Mar 3; 18(3):368-81. PMID: 26942852.
      View in: PubMed
    5. Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau B. KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 1; 143(5):810-21. PMID: 26932671.
      View in: PubMed
    6. Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau B. Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell. 2016 Feb 25; 164(5):999-1014. PMID: 26875865.
      View in: PubMed
    7. Holloway AK, Bruneau B, Sukonnik T, Rubenstein JL, Pollard KS. Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor. Mol Biol Evol. 2016 Apr; 33(4):1008-18. PMID: 26715627.
      View in: PubMed
    8. Morey L, Santanach A, Blanco E, Aloia L, Nora EP, Bruneau B, Di Croce L. Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms. Cell Stem Cell. 2015 Sep 3; 17(3):300-15. PMID: 26340528.
      View in: PubMed
    9. Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau B. Brg1 modulates enhancer activation in mesoderm lineage commitment. Development. 2015 Apr 15; 142(8):1418-30. PMID: 25813539; PMCID: PMC4392595.
    10. Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau B, Srivastava D. Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell. 2015 Mar 12; 160(6):1072-86. PMID: 25768904; PMCID: PMC4359747 [Available on 03/12/16].
    11. Simonti CN, Pollard KS, Schröder S, He D, Bruneau B, Ott M, Capra JA. Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. BMC Evol Biol. 2015; 15:35. PMID: 25887984; PMCID: PMC4362643.
    12. Kathiriya IS, Nora EP, Bruneau B. Investigating the transcriptional control of cardiovascular development. Circ Res. 2015 Feb 13; 116(4):700-14. PMID: 25677518; PMCID: PMC4332409 [Available on 02/13/16].
    13. Pourquié O, Bruneau B, Keller G, Smith A. Looking inwards: opening a window onto human development. Development. 2015 Jan 1; 142(1):1-2. PMID: 25516961.
      View in: PubMed
    14. Delgado-Olguín P, Dang LT, He D, Thomas S, Chi L, Sukonnik T, Khyzha N, Dobenecker MW, Fish JE, Bruneau B. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014 Dec; 141(23):4610-7. PMID: 25359725; PMCID: PMC4302930.
    15. Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau B. Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife. 2014; 3. PMID: 25296024; PMCID: PMC4356145.
    16. Bruneau B. Finding a niche for cardiac precursors. Elife. 2014; 3:e02993. PMID: 24843033; PMCID: PMC4007203.
    17. Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau B, Mercola M, Minucci S, Puri PL. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Dev. 2014 Apr 15; 28(8):841-57. PMID: 24682306; PMCID: PMC4003277.
    18. Dickel DE, Zhu Y, Nord AS, Wylie JN, Akiyama JA, Afzal V, Plajzer-Frick I, Kirkpatrick A, Göttgens B, Bruneau B, Visel A, Pennacchio LA. Function-based identification of mammalian enhancers using site-specific integration. Nat Methods. 2014 May; 11(5):566-71. PMID: 24658141; PMCID: PMC4008384.
    19. Bruneau B, Srivastava D. Congenital heart disease: entering a new era of human genetics. Circ Res. 2014 Feb 14; 114(4):598-9. PMID: 24526674.
      View in: PubMed
    20. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau B, Adelman K, Ott M. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 7; 52(3):314-24. PMID: 24207025; PMCID: PMC3936344.
    21. Bruneau B. An interview with Benoit Bruneau. Development. 2013 Nov; 140(22):4463-4. PMID: 24194468.
      View in: PubMed
    22. Luna-Zurita L, Bruneau B. Chromatin modulators as facilitating factors in cellular reprogramming. Curr Opin Genet Dev. 2013 Oct; 23(5):556-61. PMID: 23993229.
      View in: PubMed
    23. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau B, Srivastava D. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47. PMID: 24319660; PMCID: PMC3849259.
    24. Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013; 9(7):e1003612. PMID: 23874215; PMCID: PMC3708807.
    25. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau B, Fish JE. ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013 Jul 15; 26(1):45-58. PMID: 23830865; PMCID: PMC3754838.
    26. Pourquié O, Bruneau B, Götz M, Keller G, Smith A. Stem cells and regeneration: a special issue. Development. 2013 Jun; 140(12):2445. PMID: 23715535.
      View in: PubMed
    27. Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau B, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AP, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013; 14(3):R28. PMID: 23537068; PMCID: PMC4054807.
    28. Bruneau B. Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol. 2013 Mar; 5(3):a008292. PMID: 23457256; PMCID: PMC3578359.
    29. Star EN, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, Bruneau B, Chow RL. Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec; 139(24):4644-55. PMID: 23172916; PMCID: PMC3509726.
    30. Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau B. Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development. 2012 Nov; 139(21):4007-19. PMID: 22992950; PMCID: PMC3472592.
    31. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau B. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell. 2012 Sep 28; 151(1):206-20. PMID: 22981692; PMCID: PMC3462286.
    32. Kim KH, Rosen A, Bruneau B, Hui CC, Backx PH. Iroquois homeodomain transcription factors in heart development and function. Circ Res. 2012 May 25; 110(11):1513-24. PMID: 22628575.
      View in: PubMed
    33. Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau B. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012 Mar; 44(3):343-7. PMID: 22267199; PMCID: PMC3288669.
    34. Chang CP, Bruneau B. Epigenetics and cardiovascular development. Annu Rev Physiol. 2012; 74:41-68. PMID: 22035349.
      View in: PubMed
    35. Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau B, Backx PH. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13576-81. PMID: 21825130; PMCID: PMC3158173.
    36. Bruneau B. Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis. Can J Physiol Pharmacol. 2011 Aug; 89(8):533-7. PMID: 21806510.
      View in: PubMed
    37. Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau B, Hopyan S. Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development. 2011 Sep; 138(17):3759-67. PMID: 21795281.
      View in: PubMed
    38. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau B, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 2011 Jun 27; 193(7):1181-96. PMID: 21690310; PMCID: PMC3216339.
    39. Fish JE, Wythe JD, Xiao T, Bruneau B, Stainier DY, Srivastava D, Woo S. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development. 2011 Apr; 138(7):1409-19. PMID: 21385766; PMCID: PMC3050667.
    40. Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguín P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau B. Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun. 2011; 2:187. PMID: 21304516; PMCID: PMC3096875.
    41. Delgado-Olguín P, Brand-Arzamendi K, Scott IC, Jungblut B, Stainier DY, Bruneau B, Recillas-Targa F. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011 Apr 8; 286(14):12483-94. PMID: 21288905; PMCID: PMC3069451.
    42. Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau B, Andelfinger G, Nemer M. An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A. 2010 Nov 9; 107(45):19356-61. PMID: 20974940; PMCID: PMC2984205.
    43. Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau B, Blaschke RJ, Steinbeisser H, Rappold G. Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Hum Mol Genet. 2010 Dec 1; 19(23):4625-33. PMID: 20858598; PMCID: PMC2972695.
    44. Bruneau B. Chromatin remodeling in heart development. Curr Opin Genet Dev. 2010 Oct; 20(5):505-11. PMID: 20702085.
      View in: PubMed
    45. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau B, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 6; 142(3):375-86. PMID: 20691899; PMCID: PMC2919844.
    46. Bruneau B. Epigenetic regulation of the cardiovascular system: introduction to a review series. Circ Res. 2010 Aug 6; 107(3):324-6. PMID: 20689071; PMCID: PMC2930886.
    47. Alexander JM, Bruneau B. Lessons for cardiac regeneration and repair through development. Trends Mol Med. 2010 Sep; 16(9):426-34. PMID: 20692205; PMCID: PMC3089764.
    48. Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau B, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet. 2010 May 1; 19(9):1633-50. PMID: 20106867; PMCID: PMC2850613.
    49. Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau B, Rotin D. The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010 Feb 26; 285(9):6770-80. PMID: 20026598; PMCID: PMC2825471.
    50. Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau B. Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 3; 461(7260):95-8. PMID: 19727199; PMCID: PMC2753965.
    51. Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau B, Van Arsdell GS. NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. PLoS One. 2009; 4(5):e5698. PMID: 19479054; PMCID: PMC2684637.
    52. Takeuchi JK, Bruneau B. Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature. 2009 Jun 4; 459(7247):708-11. PMID: 19396158; PMCID: PMC2728356.
    53. Ellis J, Bruneau B, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 6; 4(3):198-9; author reply 202. PMID: 19265656.
      View in: PubMed
    54. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau B, Stainier DY, Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug; 15(2):272-84. PMID: 18694566; PMCID: PMC2604134.
    55. Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau B. Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proc Natl Acad Sci U S A. 2008 Apr 8; 105(14):5519-24. PMID: 18378906; PMCID: PMC2291114.
    56. Bruneau B. The developmental genetics of congenital heart disease. Nature. 2008 Feb 21; 451(7181):943-8. PMID: 18288184.
      View in: PubMed
    57. Feintuch A, Zhu Y, Bishop J, Davidson L, Dazai J, Bruneau B, Henkelman RM. 4D cardiac MRI in the mouse. NMR Biomed. 2007 May; 20(3):360-5. PMID: 17451168.
      View in: PubMed
    58. Bruneau B, Black BL. The heart's Da Vinci code: a Renaissance at Keystone. Development. 2007 May; 134(9):1631-3. PMID: 17395645.
      View in: PubMed
    59. Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau B. Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):846-51. PMID: 17210915; PMCID: PMC1783402.
    60. Takeuchi JK, Bruneau B. Irxl1, a divergent Iroquois homeobox family transcription factor gene. Gene Expr Patterns. 2007 Jan; 7(1-2):51-6. PMID: 16824806.
      View in: PubMed
    61. Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau B. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol. 2006 Sep 15; 297(2):566-86. PMID: 16870172.
      View in: PubMed
    62. Delgado-Olguín P, Takeuchi JK, Bruneau B. Chromatin modification and remodeling in heart development. ScientificWorldJournal. 2006; 6:1851-61. PMID: 17205192.
      View in: PubMed
    63. Bruneau B. [Irx5: a transcription factor that regulates the cardiac repolarization gradient]. Med Sci (Paris). 2006 Mar; 22(3):231-2. PMID: 16527195.
      View in: PubMed
    64. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau B. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006 Feb; 38(2):175-83. PMID: 16380715.
      View in: PubMed
    65. Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau B. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005 Oct 21; 123(2):347-58. PMID: 16239150; PMCID: PMC1480411.
    66. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau B, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005 Oct; 132(19):4375-86. PMID: 16155213.
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    67. Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau B, Birch DG, Hui CC, McInnes RR, Cheng SH. The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development. Dev Biol. 2005 Nov 1; 287(1):48-60. PMID: 16182275.
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    68. Frey BJ, Mohammad N, Morris QD, Zhang W, Robinson MD, Mnaimneh S, Chang R, Pan Q, Sat E, Rossant J, Bruneau B, Aubin JE, Blencowe BJ, Hughes TR. Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet. 2005 Sep; 37(9):991-6. PMID: 16127451.
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    69. Bruneau B. Developmental biology: tiny brakes for a growing heart. Nature. 2005 Jul 14; 436(7048):181-2. PMID: 16015310.
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    70. Pizard A, Burgon PG, Paul DL, Bruneau B, Seidman CE, Seidman JG. Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum. Mol Cell Biol. 2005 Jun; 25(12):5073-83. PMID: 15923624; PMCID: PMC1140596.
    71. Zhou YQ, Zhu Y, Bishop J, Davidson L, Henkelman RM, Bruneau B, Foster FS. Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H992-H1001. PMID: 15849237.
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    72. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau B. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005 May; 132(10):2463-74. PMID: 15843409.
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    73. Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau B, Schwartz RJ. Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes. J Biol Chem. 2005 Mar 25; 280(12):11816-28. PMID: 15591049.
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    74. Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau B. Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature. 2004 Nov 4; 432(7013):107-12. PMID: 15525990.
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    75. McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau B, Hande MP, Hakem R. Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 2004 Sep 15; 23(18):3677-88. PMID: 15343267; PMCID: PMC517611.
    76. Moskowitz IP, Pizard A, Patel VV, Bruneau B, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development. 2004 Aug; 131(16):4107-16. PMID: 15289437.
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    77. Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau B, Lindsay EA, Baldini A. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul; 131(13):3217-27. PMID: 15175244.
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    78. Mori AD, Bruneau B. TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed. Curr Opin Cardiol. 2004 May; 19(3):211-5. PMID: 15096952.
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    79. Lebel M, Agarwal P, Cheng CW, Kabir MG, Chan TY, Thanabalasingham V, Zhang X, Cohen DR, Husain M, Cheng SH, Bruneau B, Hui CC. The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Mol Cell Biol. 2003 Nov; 23(22):8216-25. PMID: 14585979; PMCID: PMC262378.
    80. Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau B, Zorn AM, Harvey RP. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol. 2003 Oct 15; 262(2):206-24. PMID: 14550786.
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    81. Rallis C, Bruneau B, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ, Logan MP. Tbx5 is required for forelimb bud formation and continued outgrowth. Development. 2003 Jun; 130(12):2741-51. PMID: 12736217.
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    82. Bruneau B. The developing heart and congenital heart defects: a make or break situation. Clin Genet. 2003 Apr; 63(4):252-61. PMID: 12702154.
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    83. Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau B. Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development. 2003 Feb; 130(3):623-33. PMID: 12490567.
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    84. Bruneau B. Transcriptional regulation of vertebrate cardiac morphogenesis. Circ Res. 2002 Mar 22; 90(5):509-19. PMID: 11909814.
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    85. Bruneau B, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001 Sep 21; 106(6):709-21. PMID: 11572777.
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    86. Bruneau B, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol. 2001 Mar; 21(5):1730-6. PMID: 11238910; PMCID: PMC86719.
    87. Bruneau B, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Dev Biol. 2000 Jan 15; 217(2):266-77. PMID: 10625552.
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    88. Bruneau B, Logan M, Davis N, Levi T, Tabin CJ, Seidman JG, Seidman CE. Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev Biol. 1999 Jul 1; 211(1):100-8. PMID: 10373308.
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    89. Ogawa T, Vatta M, Bruneau B, de Bold AJ. Characterization of natriuretic peptide production by adult heart atria. Am J Physiol. 1999 Jun; 276(6 Pt 2):H1977-86. PMID: 10362678.
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    90. Bao ZZ, Bruneau B, Seidman JG, Seidman CE, Cepko CL. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science. 1999 Feb 19; 283(5405):1161-4. PMID: 10024241.
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    91. Ogawa T, Bruneau B, Yokota N, de Bold ML, de Bold AJ. Tissue-specific regulation of renal and cardiac atrial natriuretic factor gene expression in deoxycorticosterone acetate-salt rats. Hypertension. 1997 Dec; 30(6):1342-7. PMID: 9403551.
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    92. Bruneau B, Piazza LA, de Bold AJ. BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria. Am J Physiol. 1997 Dec; 273(6 Pt 2):H2678-86. PMID: 9435604.
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    93. Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau B, Schinzel A, Seidman JG, Seidman CE, Jorde LB. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet. 1997 Jul; 16(3):311-5. PMID: 9207801.
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    94. Ogawa T, Linz W, Stevenson M, Bruneau B, Kuroski de Bold ML, Chen JH, Eid H, Schölkens BA, de Bold AJ. Evidence for load-dependent and load-independent determinants of cardiac natriuretic peptide production. Circulation. 1996 Jun 1; 93(11):2059-67. PMID: 8640983.
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    95. Bruneau B, Piazza LA, de Bold AJ. Alpha 1-adrenergic stimulation of isolated rat atria results in discoordinate increases in natriuretic peptide secretion and gene expression and enhances Egr-1 and c-Myc expression. Endocrinology. 1996 Jan; 137(1):137-43. PMID: 8536605.
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    96. Yokota N, Bruneau B, Fernandez BE, de Bold ML, Piazza LA, Eid H, de Bold AJ. Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats. Am J Hypertens. 1995 Mar; 8(3):301-10. PMID: 7540847.
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    97. Yokota N, Bruneau B, Kuroski de Bold ML, de Bold AJ. Atrial natriuretic factor significantly contributes to the mineralocorticoid escape phenomenon. Evidence for a guanylate cyclase-mediated pathway. J Clin Invest. 1994 Nov; 94(5):1938-46. PMID: 7962539; PMCID: PMC294607.
    98. Bruneau B, de Bold AJ. Selective changes in natriuretic peptide and early response gene expression in isolated rat atria following stimulation by stretch or endothelin-1. Cardiovasc Res. 1994 Oct; 28(10):1519-25. PMID: 8001040.
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