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Benoit Bruneau, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address1650 Owens St
San Francisco CA 94107
Phone415-734-2708
ORCID ORCID Icon0000-0002-0804-7597 Additional info
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    The main focus of our lab is to understand how a heart becomes a heart: what cell lineage decisions take place to direct cardiac differentiation, and what morphogenetic and patterning processes occur to assemble all of the heart's components into a functional organ. We are primarily interested in regulation of these processes by transcriptional regulatory mechanisms that include DNA-binding transcription factors, chromatin remodeling complexes, and histone modifications. We have used this knowledge to understand disease mechanisms, but also to devise strategies for cardiac regeneration.

    Why study heart development? We believe that primary defects in patterning in early heart development are at the root of congenital heart defects, which affect approximately 1% of live-born children, and we want to understand how these defects occur, to perhaps be able to uncover new and improved diagnostic or even therapeutic options. Also, by understanding how cardiac lineage specification occurs, we can better design stem cell-based interventions of cardiac repair, based on the knowledge of what drives an uncommitted cell towards a specific cardiac fate. We have recently focused our efforts on cardiac chromatin remodeling and modification factors, enzymes that unwind DNA or modify histones to turn genes on or off. We are particularly interested in how these factors control cardiac cell lineage decisions. These chromatin remodeling factors may also be key to pushing a stem cell into becoming a heart cell, perhaps opening up new avenues for cardiac regenerative medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    Genetic determinants of 4D genome folding in human cardiac development
    NIH/NHLBI U01HL157989Sep 21, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Early Cardiac Progenitors
    NIH/NHLBI R01HL114948Jul 1, 2013 - Mar 31, 2021
    Role: Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI UM1HL098179Sep 30, 2009 - Jul 31, 2020
    Role: Principal Investigator
    Induced Pluripotent Stem Cells in the Understanding and Treatment of Heart Diseas
    NIH/NHLBI U01HL100406Sep 30, 2009 - Jun 30, 2016
    Role: Co-Principal Investigator
    The Epigenetic Landscape of Heart Development
    NIH/NHLBI U01HL098179Sep 30, 2009 - Jul 31, 2015
    Role: Principal Investigator
    Iroquois Homeobox Transcription Factors in Heart Development and Physiology
    NIH/NHLBI R01HL093414Jul 1, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Induced pluripotent stem cells in the understanding and treatment of heart diseas
    NIH/NHLBI R03HL096254Dec 1, 2008 - May 31, 2009
    Role: Co-Principal Investigator
    Chromatin remodeling complexes in heart development
    NIH/NHLBI R01HL085860Sep 1, 2006 - May 31, 2011
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The developing heart: from The Wizard of Oz to congenital heart disease. Development. 2020 Oct 21; 147(21). Bruneau BG. PMID: 33087326.
      View in: PubMed   Mentions:    Fields:    
    2. Regulation of single-cell genome organization into TADs and chromatin nanodomains. Nat Genet. 2020 Nov; 52(11):1151-1157. Szabo Q, Donjon A, Jerkovic I, Papadopoulos GL, Cheutin T, Bonev B, Nora EP, Bruneau BG, Bantignies F, Cavalli G. PMID: 33077913.
      View in: PubMed   Mentions:    Fields:    
    3. Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 Sep; 21(9):1135. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Coronado PER, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32661365.
      View in: PubMed   Mentions:    Fields:    
    4. Author Correction: Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation. Genome Biol. 2020 Jun 02; 21(1):133. Nishana M, Ha C, Rodriguez-Hernaez J, Ranjbaran A, Chio E, Nora EP, Badri SB, Kloetgen A, Bruneau BG, Tsirigos A, Skok JA. PMID: 32487268.
      View in: PubMed   Mentions:    Fields:    
    5. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. J Clin Invest. 2020 Jun 01; 130(6):2966-2977. Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM. PMID: 32106109.
      View in: PubMed   Mentions: 1     Fields:    
    6. Cardiac natriuretic peptides. Nat Rev Cardiol. 2020 May 22. Goetze JP, Bruneau BG, Ramos HR, Ogawa T, de Bold MK, de Bold AJ. PMID: 32444692.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation. Genome Biol. 2020 May 11; 21(1):108. Nishana M, Ha C, Rodriguez-Hernaez J, Ranjbaran A, Chio E, Nora EP, Badri SB, Kloetgen A, Bruneau BG, Tsirigos A, Skok JA. PMID: 32393311.
      View in: PubMed   Mentions: 2     Fields:    
    8. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Development. 2019 12 09; 146(23). George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG. PMID: 31784461.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Chromatin and epigenetics in development: a Special Issue. Development. 2019 10 10; 146(19). Bruneau BG, Koseki H, Strome S, Torres-Padilla ME. PMID: 31601561.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. CTCF confers local nucleosome resiliency after DNA replication and during mitosis. Elife. 2019 10 10; 8. Owens N, Papadopoulou T, Festuccia N, Tachtsidi A, Gonzalez I, Dubois A, Vandormael-Pournin S, Nora EP, Bruneau BG, Cohen-Tannoudji M, Navarro P. PMID: 31599722.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. RNA Interactions Are Essential for CTCF-Mediated Genome Organization. Mol Cell. 2019 11 07; 76(3):412-422.e5. Saldaña-Meyer R, Rodriguez-Hernaez J, Escobar T, Nishana M, Jácome-López K, Nora EP, Bruneau BG, Tsirigos A, Furlan-Magaril M, Skok J, Reinberg D. PMID: 31522988.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards. Nat Ecol Evol. 2019 08; 3(8):1241-1252. Lind AL, Lai YYY, Mostovoy Y, Holloway AK, Iannucci A, Mak ACY, Fondi M, Orlandini V, Eckalbar WL, Milan M, Rovatsos M, Kichigin IG, Makunin AI, Johnson Pokorná M, Altmanová M, Trifonov VA, Schijlen E, Kratochvíl L, Fani R, Velenský P, Rehák I, Patarnello T, Jessop TS, Hicks JW, Ryder OA, Mendelson JR, Ciofi C, Kwok PY, Pollard KS, Bruneau BG. PMID: 31358948.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis. Development. 2019 07 05; 146(19). Hota SK, Johnson JR, Verschueren E, Thomas R, Blotnick AM, Zhu Y, Sun X, Pennacchio LA, Krogan NJ, Bruneau BG. PMID: 30814119.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs. Cell Syst. 2019 01 23; 8(1):27-42.e6. Samee MAH, Bruneau BG, Pollard KS. PMID: 30660610.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication. Cell. 2019 02 07; 176(4):816-830.e18. Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner JL, Paulsen MT, Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau BG, Ljungman M, Fraser P, Ay F, Gilbert DM. PMID: 30595451.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    17. Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. Nat Commun. 2018 11 26; 9(1):4977. Yuan X, Song M, Devine P, Bruneau BG, Scott IC, Wilson MD. PMID: 30478328.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Chromatin Domains Go on Repeat in Disease. Cell. 2018 09 20; 175(1):38-40. Bruneau BG, Nora EP. PMID: 30241613.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open. 2018 Mar 12; 7(3). Herman AM, Rhyner AM, Devine WP, Marrelli SP, Bruneau BG, Wythe JD. PMID: 29437553.
      View in: PubMed   Mentions:
    20. Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. Biol Open. 2018 Jan 05; 7(1). Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG. PMID: 29183906.
      View in: PubMed   Mentions:
    21. Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization. Cell. 2017 May 18; 169(5):930-944.e22. Nora EP, Goloborodko A, Valton AL, Gibcus JH, Uebersohn A, Abdennur N, Dekker J, Mirny LA, Bruneau BG. PMID: 28525758.
      View in: PubMed   Mentions: 191     Fields:    Translation:AnimalsCells
    22. Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites. Development. 2017 04 01; 144(7):1235-1241. Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL. PMID: 28351867.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. PMID: 27840107.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    24. ATP-dependent chromatin remodeling during mammalian development. Development. 2016 08 15; 143(16):2882-97. Hota SK, Bruneau BG. PMID: 27531948.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    25. Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization. Bone Rep. 2016 Dec; 5:86-95. Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC. PMID: 27453922.
      View in: PubMed   Mentions:
    26. Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts. Cell Stem Cell. 2016 Mar 03; 18(3):368-81. Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. PMID: 26942852.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    27. KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016 Mar 01; 143(5):810-21. Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG. PMID: 26932671.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell. 2016 Feb 25; 164(5):999-1014. Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG. PMID: 26875865.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    29. Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor. Mol Biol Evol. 2016 Apr; 33(4):1008-18. Holloway AK, Bruneau BG, Sukonnik T, Rubenstein JL, Pollard KS. PMID: 26715627.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms. Cell Stem Cell. 2015 Sep 03; 17(3):300-15. Morey L, Santanach A, Blanco E, Aloia L, Nora EP, Bruneau BG, Di Croce L. PMID: 26340528.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    31. Brg1 modulates enhancer activation in mesoderm lineage commitment. Development. 2015 Apr 15; 142(8):1418-30. Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau BG. PMID: 25813539.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    32. Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell. 2015 Mar 12; 160(6):1072-86. Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D. PMID: 25768904.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    33. Evolution of lysine acetylation in the RNA polymerase II C-terminal domain. BMC Evol Biol. 2015 Mar 10; 15:35. Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA. PMID: 25887984.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    34. Investigating the transcriptional control of cardiovascular development. Circ Res. 2015 Feb 13; 116(4):700-14. Kathiriya IS, Nora EP, Bruneau BG. PMID: 25677518.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    35. Looking inwards: opening a window onto human development. Development. 2015 Jan 01; 142(1):1-2. Pourquié O, Bruneau B, Keller G, Smith A. PMID: 25516961.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    36. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014 Dec; 141(23):4610-7. Delgado-Olguín P, Dang LT, He D, Thomas S, Chi L, Sukonnik T, Khyzha N, Dobenecker MW, Fish JE, Bruneau BG. PMID: 25359725.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    37. Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife. 2014 Oct 08; 3. Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG. PMID: 25296024.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    38. Finding a niche for cardiac precursors. Elife. 2014 May 06; 3:e02993. Bruneau BG. PMID: 24843033.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    39. HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Dev. 2014 Apr 15; 28(8):841-57. Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau BG, Mercola M, Minucci S, Puri PL. PMID: 24682306.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    40. Function-based identification of mammalian enhancers using site-specific integration. Nat Methods. 2014 May; 11(5):566-71. Dickel DE, Zhu Y, Nord AS, Wylie JN, Akiyama JA, Afzal V, Plajzer-Frick I, Kirkpatrick A, Göttgens B, Bruneau BG, Visel A, Pennacchio LA. PMID: 24658141.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    41. Congenital heart disease: entering a new era of human genetics. Circ Res. 2014 Feb 14; 114(4):598-9. Bruneau BG, Srivastava D. PMID: 24526674.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    42. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Mol Cell. 2013 Nov 07; 52(3):314-24. Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M. PMID: 24207025.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    43. An interview with Benoit Bruneau. Development. 2013 Nov; 140(22):4463-4. Bruneau B. PMID: 24194468.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    44. Chromatin modulators as facilitating factors in cellular reprogramming. Curr Opin Genet Dev. 2013 Oct; 23(5):556-61. Luna-Zurita L, Bruneau BG. PMID: 23993229.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    45. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. PMID: 24319660.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    46. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. PLoS Genet. 2013; 9(7):e1003612. Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL. PMID: 23874215.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    47. ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013 Jul 15; 26(1):45-58. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE. PMID: 23830865.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    48. Stem cells and regeneration: a special issue. Development. 2013 Jun; 140(12):2445. Pourquié O, Bruneau B, Götz M, Keller G, Smith A. PMID: 23715535.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    49. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013 Mar 28; 14(3):R28. Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AP, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK. PMID: 23537068.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    50. Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol. 2013 Mar 01; 5(3):a008292. Bruneau BG. PMID: 23457256.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    51. Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec; 139(24):4644-55. Star EN, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL. PMID: 23172916.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    52. Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development. 2012 Nov; 139(21):4007-19. Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG. PMID: 22992950.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    53. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell. 2012 Sep 28; 151(1):206-20. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG. PMID: 22981692.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansAnimalsCells
    54. Iroquois homeodomain transcription factors in heart development and function. Circ Res. 2012 May 25; 110(11):1513-24. Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH. PMID: 22628575.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    55. Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet. 2012 Jan 22; 44(3):343-7. Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG. PMID: 22267199.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    56. Epigenetics and cardiovascular development. Annu Rev Physiol. 2012; 74:41-68. Chang CP, Bruneau BG. PMID: 22035349.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    57. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13576-81. Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH. PMID: 21825130.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    58. Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis. Can J Physiol Pharmacol. 2011 Aug; 89(8):533-7. Bruneau BG. PMID: 21806510.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    59. Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb. Development. 2011 Sep; 138(17):3759-67. Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S. PMID: 21795281.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    60. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 2011 Jun 27; 193(7):1181-96. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. PMID: 21690310.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    61. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development. 2011 Apr; 138(7):1409-19. Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S. PMID: 21385766.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    62. Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nat Commun. 2011 Feb 08; 2:187. Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguín P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS, Scott IC, Bruneau BG. PMID: 21304516.
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    63. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011 Apr 08; 286(14):12483-94. Delgado-Olguín P, Brand-Arzamendi K, Scott IC, Jungblut B, Stainier DY, Bruneau BG, Recillas-Targa F. PMID: 21288905.
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    64. An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19356-61. Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M. PMID: 20974940.
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    65. Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Hum Mol Genet. 2010 Dec 01; 19(23):4625-33. Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H, Rappold G. PMID: 20858598.
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    66. Chromatin remodeling in heart development. Curr Opin Genet Dev. 2010 Oct; 20(5):505-11. Bruneau BG. PMID: 20702085.
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    67. Epigenetic regulation of the cardiovascular system: introduction to a review series. Circ Res. 2010 Aug 06; 107(3):324-6. Bruneau BG. PMID: 20689071.
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    68. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 06; 142(3):375-86. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. PMID: 20691899.
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    69. Lessons for cardiac regeneration and repair through development. Trends Mol Med. 2010 Sep; 16(9):426-34. Alexander JM, Bruneau BG. PMID: 20692205.
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    70. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet. 2010 May 01; 19(9):1633-50. Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL. PMID: 20106867.
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    71. The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 2010 Feb 26; 285(9):6770-80. Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D. PMID: 20026598.
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    72. Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 03; 461(7260):95-8. Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG. PMID: 19727199.
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    73. NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes. PLoS One. 2009 May 28; 4(5):e5698. Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS. PMID: 19479054.
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    74. Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature. 2009 Jun 04; 459(7247):708-11. Takeuchi JK, Bruneau BG. PMID: 19396158.
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    75. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 06; 4(3):198-9; author reply 202. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. PMID: 19265656.
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    76. Influence of cysteamine on in vitro maturation, in vitro and in vivo fertilization of equine oocytes. Reprod Domest Anim. 2010 Feb; 45(1):1-7. Deleuze S, Dubois CS, Caillaud M, Bruneau B, Goudet G, Duchamp G. PMID: 18992121.
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    77. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug; 15(2):272-84. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. PMID: 18694566.
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    78. Tbx5-dependent pathway regulating diastolic function in congenital heart disease. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5519-24. Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG. PMID: 18378906.
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    79. The developmental genetics of congenital heart disease. Nature. 2008 Feb 21; 451(7181):943-8. Bruneau BG. PMID: 18288184.
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    80. 4D cardiac MRI in the mouse. NMR Biomed. 2007 May; 20(3):360-5. Feintuch A, Zhu Y, Bishop J, Davidson L, Dazai J, Bruneau BG, Henkelman RM. PMID: 17451168.
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    81. The heart's Da Vinci code: a Renaissance at Keystone. Development. 2007 May; 134(9):1631-3. Bruneau BG, Black BL. PMID: 17395645.
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    82. Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):846-51. Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG. PMID: 17210915.
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    83. Irxl1, a divergent Iroquois homeobox family transcription factor gene. Gene Expr Patterns. 2007 Jan; 7(1-2):51-6. Takeuchi JK, Bruneau BG. PMID: 16824806.
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    84. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol. 2006 Sep 15; 297(2):566-86. Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG. PMID: 16870172.
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    85. Chromatin modification and remodeling in heart development. ScientificWorldJournal. 2006 Apr 24; 6:1851-61. Delgado-Olguín P, Takeuchi JK, Bruneau BG. PMID: 17205192.
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    86. [Irx5: a transcription factor that regulates the cardiac repolarization gradient]. Med Sci (Paris). 2006 Mar; 22(3):231-2. Bruneau BG. PMID: 16527195.
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    87. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006 Feb; 38(2):175-83. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG. PMID: 16380715.
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    88. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005 Oct 21; 123(2):347-58. Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG. PMID: 16239150.
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    89. A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development. 2005 Oct; 132(19):4375-86. Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. PMID: 16155213.
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    90. The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development. Dev Biol. 2005 Nov 01; 287(1):48-60. Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR, Cheng SH. PMID: 16182275.
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    91. Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet. 2005 Sep; 37(9):991-6. Frey BJ, Mohammad N, Morris QD, Zhang W, Robinson MD, Mnaimneh S, Chang R, Pan Q, Sat E, Rossant J, Bruneau BG, Aubin JE, Blencowe BJ, Hughes TR. PMID: 16127451.
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    92. Developmental biology: tiny brakes for a growing heart. Nature. 2005 Jul 14; 436(7048):181-2. Bruneau BG. PMID: 16015310.
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    93. Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum. Mol Cell Biol. 2005 Jun; 25(12):5073-83. Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG. PMID: 15923624.
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    94. Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome. . 2005 Sep; 289(3):H992-H1001. Zhou YQ, Zhu Y, Bishop J, Davidson L, Henkelman RM, Bruneau BG, Foster FS. PMID: 15849237.
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    95. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005 May; 132(10):2463-74. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG. PMID: 15843409.
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    96. Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes. J Biol Chem. 2005 Mar 25; 280(12):11816-28. Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ. PMID: 15591049.
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    97. The functional landscape of mouse gene expression. J Biol. 2004; 3(5):21. Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, Mohammad N, Robinson MD, Zirngibl R, Somogyi E, Laurin N, Eftekharpour E, Sat E, Grigull J, Pan Q, Peng WT, Krogan N, Greenblatt J, Fehlings M, van der Kooy D, Aubin J, Bruneau BG, Rossant J, Blencowe BJ, Frey BJ, Hughes TR. PMID: 15588312.
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    98. Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature. 2004 Nov 04; 432(7013):107-12. Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG. PMID: 15525990.
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    99. Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 2004 Sep 15; 23(18):3677-88. McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau BG, Hande MP, Hakem R. PMID: 15343267.
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    100. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development. 2004 Aug; 131(16):4107-16. Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG. PMID: 15289437.
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    101. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul; 131(13):3217-27. Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau BG, Lindsay EA, Baldini A. PMID: 15175244.
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    102. TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed. Curr Opin Cardiol. 2004 May; 19(3):211-5. Mori AD, Bruneau BG. PMID: 15096952.
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    103. The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Mol Cell Biol. 2003 Nov; 23(22):8216-25. Lebel M, Agarwal P, Cheng CW, Kabir MG, Chan TY, Thanabalasingham V, Zhang X, Cohen DR, Husain M, Cheng SH, Bruneau BG, Hui CC. PMID: 14585979.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    104. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol. 2003 Oct 15; 262(2):206-24. Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP. PMID: 14550786.
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    105. Tbx5 is required for forelimb bud formation and continued outgrowth. Development. 2003 Jun; 130(12):2741-51. Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ, Logan MP. PMID: 12736217.
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    106. The developing heart and congenital heart defects: a make or break situation. Clin Genet. 2003 Apr; 63(4):252-61. Bruneau BG. PMID: 12702154.
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    107. Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development. 2003 Feb; 130(3):623-33. Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG. PMID: 12490567.
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    108. Transcriptional regulation of vertebrate cardiac morphogenesis. Circ Res. 2002 Mar 22; 90(5):509-19. Bruneau BG. PMID: 11909814.
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    109. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001 Sep 21; 106(6):709-21. Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG. PMID: 11572777.
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    110. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol. 2001 Mar; 21(5):1730-6. Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. PMID: 11238910.
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    111. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Dev Biol. 2000 Jan 15; 217(2):266-77. Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE. PMID: 10625552.
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    112. Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev Biol. 1999 Jul 01; 211(1):100-8. Bruneau BG, Logan M, Davis N, Levi T, Tabin CJ, Seidman JG, Seidman CE. PMID: 10373308.
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    113. Characterization of natriuretic peptide production by adult heart atria. Am J Physiol. 1999 06; 276(6):H1977-86. Ogawa T, Vatta M, Bruneau BG, de Bold AJ. PMID: 10362678.
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    114. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science. 1999 Feb 19; 283(5405):1161-4. Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL. PMID: 10024241.
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    115. BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria. Am J Physiol. 1997 12; 273(6):H2678-86. Bruneau BG, Piazza LA, de Bold AJ. PMID: 9435604.
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    116. Tissue-specific regulation of renal and cardiac atrial natriuretic factor gene expression in deoxycorticosterone acetate-salt rats. Hypertension. 1997 Dec; 30(6):1342-7. Ogawa T, Bruneau BG, Yokota N, de Bold ML, de Bold AJ. PMID: 9403551.
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    117. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet. 1997 Jul; 16(3):311-5. Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Schinzel A, Seidman JG, Seidman CE, Jorde LB. PMID: 9207801.
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    118. Evidence for load-dependent and load-independent determinants of cardiac natriuretic peptide production. Circulation. 1996 Jun 01; 93(11):2059-67. Ogawa T, Linz W, Stevenson M, Bruneau BG, Kuroski de Bold ML, Chen JH, Eid H, Schölkens BA, de Bold AJ. PMID: 8640983.
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    119. Alpha 1-adrenergic stimulation of isolated rat atria results in discoordinate increases in natriuretic peptide secretion and gene expression and enhances Egr-1 and c-Myc expression. Endocrinology. 1996 Jan; 137(1):137-43. Bruneau BG, Piazza LA, de Bold AJ. PMID: 8536605.
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    120. Mechanical and neuroendocrine regulation of the endocrine heart. Cardiovasc Res. 1996 Jan; 31(1):7-18. de Bold AJ, Bruneau BG, Kuroski de Bold ML. PMID: 8849584.
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    121. Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats. Am J Hypertens. 1995 Mar; 8(3):301-10. Yokota N, Bruneau BG, Fernandez BE, de Bold ML, Piazza LA, Eid H, de Bold AJ. PMID: 7540847.
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    122. Atrial natriuretic factor significantly contributes to the mineralocorticoid escape phenomenon. Evidence for a guanylate cyclase-mediated pathway. J Clin Invest. 1994 Nov; 94(5):1938-46. Yokota N, Bruneau BG, Kuroski de Bold ML, de Bold AJ. PMID: 7962539.
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    123. Selective changes in natriuretic peptide and early response gene expression in isolated rat atria following stimulation by stretch or endothelin-1. Cardiovasc Res. 1994 Oct; 28(10):1519-25. Bruneau BG, de Bold AJ. PMID: 8001040.
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