David Sretavan, MD, PhD

Title(s)Professor Emeritus, Ophthalmology
SchoolSchool of Medicine
Address10 Koret Way
San Francisco CA 94117
Phone415-476-0840
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    Collapse Biography 
    Collapse Education and Training
    McGill UniversityB.Sc. Honors1980Physiology
    Stanford UniversityM.D.1987Medicine
    Stanford UniversityPh.D.1987Neurobiology
    Rockefeller UniversityPostdoctoral Research1990Laboratory of Neurobiology
    University of California San FranciscoPostdoctoral Research1992HHMI

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Intraocular Pressure Sensing Using Light
    NIH R01EY024582Dec 1, 2015 - Nov 30, 2019
    Role: Principal Investigator
    Microscale Axon Repair As A Novel Paradigm For Nerve Injuries
    NIH R01NS062690Jul 15, 2008 - Dec 30, 2012
    Role: Principal Investigator
    Axon Guidance Molecules and Optic Nerve Disease
    NIH R03EY016691Aug 1, 2005 - Jul 31, 2008
    Role: Principal Investigator
    P30 - Core Grant for Vision Research
    NIH P30EY002162Mar 1, 1997 - Jun 30, 2024
    Role: Co-Investigator
    Enhanced Axon Sparing In Glaucoma Through Augmentation Of EphB/ephrin B Signaling
    NIH R01EY010688Jul 1, 1994 - Jun 30, 2017
    Role: Principal Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Precision pulse capsulotomy: performance metrics and utility in routine and complex cases. J Cataract Refract Surg. 2020 Nov; 46(11):1522-1529. Ifantides C, Lee J, Rouweyha R, Vital M, Sretavan D. PMID: 32675651.
      View in: PubMed   Mentions: 2     Fields:    
    2. Fabry-Pérot optical sensor and portable detector for monitoring high-resolution ocular hemodynamics. IEEE Photonics Technol Lett. 2019 Mar 15; 31(6):423-426. Lee JO, Narasimhan V, Balakrishna A, Smith MR, Du J, Sretavan D, Choo H. PMID: 31772487.
      View in: PubMed   Mentions:
    3. Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices. Nat Nanotechnol. 2018 06; 13(6):512-519. Narasimhan V, Siddique RH, Lee JO, Kumar S, Ndjamen B, Du J, Hong N, Sretavan D, Choo H. PMID: 29713074.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. A microscale optical implant for continuous in vivo monitoring of intraocular pressure. Microsyst Nanoeng. 2017; 3:17057. Lee JO, Park H, Du J, Balakrishna A, Chen O, Sretavan D, Choo H. PMID: 31057882.
      View in: PubMed   Mentions:
    5. Real-Time In Vivo Intraocular Pressure Monitoring using an Optomechanical Implant and an Artificial Neural Network. IEEE Sens J. 2017; 17(22):7394-7404. Kim KH, Lee JO, Du J, Sretavan D, Choo H. PMID: 29422780.
      View in: PubMed   Mentions:
    6. Intraocular Sensors: Biocompatible Multifunctional Black-Silicon for Implantable Intraocular Sensor (Adv. Healthcare Mater. 4/2017). Advanced Healthcare Materials. 2017 Feb 1; 6(4). Jeong Oen Lee, Vinayak Narasimhan, Juan Du, Blaise Ndjamen, David Sretavan, Hyuck Choo. .
      View in: Publisher Site   Mentions:
    7. Biocompatible Multifunctional Black-Silicon for Implantable Intraocular Sensor. Adv Healthc Mater. 2017 Feb; 6(4). Lee JO, Narasimhan V, Du J, Ndjamen B, Sretavan D, Choo H. PMID: 28081305.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    8. Regulation of axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 2015 Jun; 18(6):817-25. Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN. PMID: 25961792.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    9. Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma. J Neurosci. 2012 Nov 07; 32(45):15859-76. Fu CT, Sretavan DW. PMID: 23136425.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. Rabbit models for continuous curvilinear capsulorhexis instruction. J Cataract Refract Surg. 2012 Jul; 38(7):1266-70. Ruggiero J, Keller C, Porco T, Naseri A, Sretavan DW. PMID: 22727296.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Jan 05; 53(1):76-84. Fu CT, Sretavan D. PMID: 22064993.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Axon repair: surgical application at a subcellular scale. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Mar-Apr; 2(2):151-61. Chang WC, Hawkes E, Keller CG, Sretavan DW. PMID: 20101712.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Axonal/glial upregulation of EphB/ephrin-B signaling in mouse experimental ocular hypertension. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):991-1001. Fu CT, Tran T, Sretavan D. PMID: 19815726.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    14. Laser-induced ocular hypertension in albino CD-1 mice. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):980-90. Fu CT, Sretavan D. PMID: 19815738.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    15. Single cell and neural process experimentation using laterally applied electrical fields between pairs of closely apposed microelectrodes with vertical sidewalls. Biosens Bioelectron. 2009 Aug 15; 24(12):3600-7. Chang WC, Sretavan DW. PMID: 19535240.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Microtechnology and nanotechnology in nerve repair. Neurol Res. 2008 Dec; 30(10):1053-62. Chang WC, Kliot M, Sretavan DW. PMID: 19079980.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    17. Novel high-resolution micropatterning for neuron culture using polylysine adsorption on a cell repellant, plasma-polymerized background. Langmuir. 2008 Nov 18; 24(22):13048-57. Chang WC, Sretavan DW. PMID: 18925765.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5567-81. Du J, Tran T, Fu C, Sretavan DW. PMID: 18055806.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. In vivo use of a nanoknife for axon microsurgery. Neurosurgery. 2007 Oct; 61(4):683-91; discussion 691-2. Chang WC, Hawkes EA, Kliot M, Sretavan DW. PMID: 17986929.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. Microtechnology in medicine: the emergence of surgical microdevices. Clin Neurosurg. 2007; 54:137-47. Chang WC, Sretavan DW. PMID: 18504911.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Eph/ephrin signaling as a potential therapeutic target after central nervous system injury. Curr Pharm Des. 2007; 13(24):2507-18. Du J, Fu C, Sretavan DW. PMID: 17692019.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    22. EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 2006 Mar 22; 26(12):3087-101. Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan DW. PMID: 16554460.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    23. Optic nerve formation. Retinal Development. 2006 Jan 1; 150-171. David W. Sretavan. .
      View in: Publisher Site   Mentions:
    24. Isolation of neuronal substructures and precise neural microdissection using a nanocutting device. J Neurosci Methods. 2006 Apr 15; 152(1-2):83-90. Chang WC, Keller CG, Sretavan DW. PMID: 16253341.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Microscale Surgery on Single Axons. Neurosurgery. 2005 Oct 1; 57(4):635-646. David W. Sretavan, Wesley Chang, Elizabeth Hawkes, Christopher Keller, Michel Kliot. .
      View in: Publisher Site   Mentions:
    26. Microscale surgery on single axons. Neurosurgery. 2005 Oct; 57(4):635-46; discussion 635-46. Sretavan DW, Chang W, Hawkes E, Keller C, Kliot M. PMID: 16239875.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron. 2004 Dec 16; 44(6):961-75. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL. PMID: 15603739.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    28. An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J Neurosci. 2004 May 26; 24(21):4989-99. Goldberg JL, Vargas ME, Wang JT, Mandemakers W, Oster SF, Sretavan DW, Barres BA. PMID: 15163691.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    29. L1/Laminin modulation of growth cone response to EphB triggers growth pauses and regulates the microtubule destabilizing protein SCG10. J Neurosci. 2004 Feb 25; 24(8):1976-86. Suh LH, Oster SF, Soehrman SS, Grenningloh G, Sretavan DW. PMID: 14985440.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    30. Ganglion cell axon pathfinding in the retina and optic nerve. Semin Cell Dev Biol. 2004 Feb; 15(1):125-36. Oster SF, Deiner M, Birgbauer E, Sretavan DW. PMID: 15036215.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    31. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron. 2003 Oct 30; 40(3):501-14. Beggs HE, Schahin-Reed D, Zang K, Goebbels S, Nave KA, Gorski J, Jones KR, Sretavan D, Reichardt LF. PMID: 14642275.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    32. Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance. Br J Ophthalmol. 2003 May; 87(5):639-45. Oster SF, Sretavan DW. PMID: 12714414.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    33. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. Development. 2003 Feb; 130(4):775-84. Oster SF, Bodeker MO, He F, Sretavan DW. PMID: 12506007.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    34. Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues. Development. 2001 Aug; 128(15):3041-8. Birgbauer E, Oster SF, Severin CG, Sretavan DW. PMID: 11532925.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    35. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000 Mar; 127(6):1231-41. Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M. PMID: 10683176.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    36. GAP-43 mediates retinal axon interaction with lateral diencephalon cells during optic tract formation. Development. 2000 Mar; 127(5):969-80. Zhang F, Lu C, Severin C, Sretavan DW. PMID: 10662636.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    37. Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice. J Neurosci. 1999 Nov 15; 19(22):9900-12. Deiner MS, Sretavan DW. PMID: 10559399.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    38. Randomized retinal ganglion cell axon routing at the optic chiasm of GAP-43-deficient mice: association with midline recrossing and lack of normal ipsilateral axon turning. J Neurosci. 1998 Dec 15; 18(24):10502-13. Sretavan DW, Kruger K. PMID: 9852588.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43. J Neurosci. 1998 Aug 01; 18(15):5692-705. Kruger K, Tam AS, Lu C, Sretavan DW. PMID: 9671660.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    40. Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron. 1997 Sep; 19(3):575-89. Deiner MS, Kennedy TE, Fazeli A, Serafini T, Tessier-Lavigne M, Sretavan DW. PMID: 9331350.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    41. Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons. Science. 1995 Jul 07; 269(5220):98-101. Sretavan DW, Puré E, Siegel MW, Reichardt LF. PMID: 7541558.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    42. Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth. Neuron. 1994 May; 12(5):957-75. Sretavan DW, Feng L, Puré E, Reichardt LF. PMID: 7514428.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    43. Time-lapse video analysis of retinal ganglion cell axon pathfinding at the mammalian optic chiasm: growth cone guidance using intrinsic chiasm cues. Neuron. 1993 Apr; 10(4):761-77. Sretavan DW, Reichardt LF. PMID: 8386532.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    44. Pathfinding at the mammalian optic chiasm. Curr Opin Neurobiol. 1993 Feb; 3(1):45-52. Sretavan DW. PMID: 8453289.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. Specific routing of retinal ganglion cell axons at the mammalian optic chiasm during embryonic development. J Neurosci. 1990 Jun; 10(6):1995-2007. Sretavan DW. PMID: 2162389.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    46. Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin. Nature. 1988 Dec 01; 336(6198):468-71. Sretavan DW, Shatz CJ, Stryker MP. PMID: 2461517.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    47. Axon arbors of X and Y retinal ganglion cells are differentially affected by prenatal disruption of binocular inputs. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7361-5. Garraghty PE, Shatz CJ, Sretavan DW, Sur M. PMID: 3174640.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    48. Prenatal development of cat retinogeniculate axon arbors in the absence of binocular interactions. J Neurosci. 1986 Apr; 6(4):990-1003. Sretavan DW, Shatz CJ. PMID: 3701418.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    49. Prenatal development of retinal ganglion cell axons: segregation into eye-specific layers within the cat's lateral geniculate nucleus. J Neurosci. 1986 Jan; 6(1):234-51. Sretavan DW, Shatz CJ. PMID: 3944621.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
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