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David Sretavan, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentOphthalmology
Address10 Koret Way
San Francisco CA 94143
Phone415-476-0840
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    Collapse Biography 
    Collapse Education and Training
    McGill UniversityB.Sc. Honors1980Physiology
    Stanford UniversityM.D.1987Medicine
    Stanford UniversityPh.D.1987Neurobiology
    Rockefeller UniversityPostdoctoral Research1990Laboratory of Neurobiology
    University of California San FranciscoPostdoctoral Research1992HHMI

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Intraocular Pressure Sensing Using Light
    NIH/NEI R01EY024582Dec 1, 2015 - Nov 30, 2019
    Role: Principal Investigator
    Microscale Axon Repair As A Novel Paradigm For Nerve Injuries
    NIH/NINDS R01NS062690Jul 15, 2008 - Dec 30, 2012
    Role: Principal Investigator
    Axon Guidance Molecules and Optic Nerve Disease
    NIH/NEI R03EY016691Aug 1, 2005 - Jul 31, 2008
    Role: Principal Investigator
    Enhanced Axon Sparing In Glaucoma Through Augmentation Of EphB/ephrin B Signaling
    NIH/NEI R01EY010688Jul 1, 1994 - Jun 30, 2016
    Role: Principal Investigator
    P30 - CENTER CORE GRANT FOR VISION RESEARCH
    NIH/NEI P30EY002162Dec 1, 1977 - Jun 30, 2019
    Role: Co-Investigator
    California National Primate Research Center
    NIH P51RR000169Jun 1, 1975 - Apr 30, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN. Regulation of axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 2015 Jun; 18(6):817-25. PMID: 25961792; PMCID: PMC4446171 [Available on 12/01/15].
      View in: PubMed, PubMed Central
    2. Fu CT, Sretavan D. Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma. J Neurosci. 2012 Nov 7; 32(45):15859-76. PMID: 23136425; PMCID: PMC3752140.
      View in: PubMed, PubMed Central
    3. Ruggiero J, Keller C, Porco T, Naseri A, Sretavan D. Rabbit models for continuous curvilinear capsulorhexis instruction. J Cataract Refract Surg. 2012 Jul; 38(7):1266-70. PMID: 22727296; PMCID: PMC3383622.
      View in: PubMed, PubMed Central
    4. Fu CT, Sretavan D. Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Jan; 53(1):76-84. PMID: 22064993; PMCID: PMC3292385.
      View in: PubMed, PubMed Central
    5. Chang WC, Hawkes E, Keller CG, Sretavan D. Axon repair: surgical application at a subcellular scale. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Mar-Apr; 2(2):151-61. PMID: 20101712; PMCID: PMC3150872.
      View in: PubMed, PubMed Central
    6. Fu CT, Tran T, Sretavan D. Axonal/glial upregulation of EphB/ephrin-B signaling in mouse experimental ocular hypertension. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):991-1001. PMID: 19815726; PMCID: PMC2868457.
      View in: PubMed, PubMed Central
    7. Fu CT, Sretavan D. Laser-induced ocular hypertension in albino CD-1 mice. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):980-90. PMID: 19815738; PMCID: PMC2868470.
      View in: PubMed, PubMed Central
    8. Chang WC, Sretavan D. Single cell and neural process experimentation using laterally applied electrical fields between pairs of closely apposed microelectrodes with vertical sidewalls. Biosens Bioelectron. 2009 Aug 15; 24(12):3600-7. PMID: 19535240; PMCID: PMC2907170.
      View in: PubMed, PubMed Central
    9. Chang WC, Kliot M, Sretavan D. Microtechnology and nanotechnology in nerve repair. Neurol Res. 2008 Dec; 30(10):1053-62. PMID: 19079980.
      View in: PubMed
    10. Chang WC, Sretavan D. Novel high-resolution micropatterning for neuron culture using polylysine adsorption on a cell repellant, plasma-polymerized background. Langmuir. 2008 Nov 18; 24(22):13048-57. PMID: 18925765; PMCID: PMC2767107.
      View in: PubMed, PubMed Central
    11. Du J, Tran T, Fu C, Sretavan D. Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5567-81. PMID: 18055806.
      View in: PubMed
    12. Chang WC, Hawkes EA, Kliot M, Sretavan D. In vivo use of a nanoknife for axon microsurgery. Neurosurgery. 2007 Oct; 61(4):683-91; discussion 691-2. PMID: 17986929.
      View in: PubMed
    13. Du J, Fu C, Sretavan D. Eph/ephrin signaling as a potential therapeutic target after central nervous system injury. Curr Pharm Des. 2007; 13(24):2507-18. PMID: 17692019.
      View in: PubMed
    14. Chang WC, Sretavan D. Microtechnology in medicine: the emergence of surgical microdevices. Clin Neurosurg. 2007; 54:137-47. PMID: 18504911.
      View in: PubMed
    15. Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan D. EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J Neurosci. 2006 Mar 22; 26(12):3087-101. PMID: 16554460.
      View in: PubMed
    16. Chang WC, Keller CG, Sretavan D. Isolation of neuronal substructures and precise neural microdissection using a nanocutting device. J Neurosci Methods. 2006 Apr 15; 152(1-2):83-90. PMID: 16253341.
      View in: PubMed
    17. Sretavan D, Chang W, Hawkes E, Keller C, Kliot M. Microscale surgery on single axons. Neurosurgery. 2005 Oct; 57(4):635-46; discussion 635-46. PMID: 16239875.
      View in: PubMed
    18. Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan D, Giger RJ, Kolodkin AL. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron. 2004 Dec 16; 44(6):961-75. PMID: 15603739.
      View in: PubMed
    19. Goldberg JL, Vargas ME, Wang JT, Mandemakers W, Oster SF, Sretavan D, Barres BA. An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells. J Neurosci. 2004 May 26; 24(21):4989-99. PMID: 15163691.
      View in: PubMed
    20. Suh LH, Oster SF, Soehrman SS, Grenningloh G, Sretavan D. L1/Laminin modulation of growth cone response to EphB triggers growth pauses and regulates the microtubule destabilizing protein SCG10. J Neurosci. 2004 Feb 25; 24(8):1976-86. PMID: 14985440.
      View in: PubMed
    21. Oster SF, Deiner M, Birgbauer E, Sretavan D. Ganglion cell axon pathfinding in the retina and optic nerve. Semin Cell Dev Biol. 2004 Feb; 15(1):125-36. PMID: 15036215.
      View in: PubMed
    22. Beggs HE, Schahin-Reed D, Zang K, Goebbels S, Nave KA, Gorski J, Jones KR, Sretavan D, Reichardt LF. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron. 2003 Oct 30; 40(3):501-14. PMID: 14642275; PMCID: PMC2758566.
      View in: PubMed, PubMed Central
    23. Oster SF, Sretavan D. Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance. Br J Ophthalmol. 2003 May; 87(5):639-45. PMID: 12714414; PMCID: PMC1771639.
      View in: PubMed, PubMed Central
    24. Oster SF, Bodeker MO, He F, Sretavan D. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. Development. 2003 Feb; 130(4):775-84. PMID: 12506007.
      View in: PubMed
    25. Birgbauer E, Oster SF, Severin CG, Sretavan D. Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues. Development. 2001 Aug; 128(15):3041-8. PMID: 11532925.
      View in: PubMed
    26. Birgbauer E, Cowan CA, Sretavan D, Henkemeyer M. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000 Mar; 127(6):1231-41. PMID: 10683176.
      View in: PubMed
    27. Zhang F, Lu C, Severin C, Sretavan D. GAP-43 mediates retinal axon interaction with lateral diencephalon cells during optic tract formation. Development. 2000 Mar; 127(5):969-80. PMID: 10662636.
      View in: PubMed
    28. Deiner MS, Sretavan D. Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice. J Neurosci. 1999 Nov 15; 19(22):9900-12. PMID: 10559399.
      View in: PubMed
    29. Marcus RC, Shimamura K, Sretavan D, Lai E, Rubenstein JL, Mason CA. Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells. J Comp Neurol. 1999 Jan 18; 403(3):346-58. PMID: 9886035.
      View in: PubMed
    30. Sretavan D, Kruger K. Randomized retinal ganglion cell axon routing at the optic chiasm of GAP-43-deficient mice: association with midline recrossing and lack of normal ipsilateral axon turning. J Neurosci. 1998 Dec 15; 18(24):10502-13. PMID: 9852588.
      View in: PubMed
    31. Kruger K, Tam AS, Lu C, Sretavan D. Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43. J Neurosci. 1998 Aug 1; 18(15):5692-705. PMID: 9671660.
      View in: PubMed
    32. Mason CA, Sretavan D. Glia, neurons, and axon pathfinding during optic chiasm development. Curr Opin Neurobiol. 1997 Oct; 7(5):647-53. PMID: 9384544.
      View in: PubMed
    33. Deiner MS, Kennedy TE, Fazeli A, Serafini T, Tessier-Lavigne M, Sretavan D. Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. Neuron. 1997 Sep; 19(3):575-89. PMID: 9331350.
      View in: PubMed
    34. Sretavan D, Puré E, Siegel MW, Reichardt LF. Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons. Science. 1995 Jul 7; 269(5220):98-101. PMID: 7541558.
      View in: PubMed
    35. Sretavan D, Feng L, Puré E, Reichardt LF. Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth. Neuron. 1994 May; 12(5):957-75. PMID: 7514428; PMCID: PMC2711898.
      View in: PubMed, PubMed Central
    36. Sretavan D, Reichardt LF. Time-lapse video analysis of retinal ganglion cell axon pathfinding at the mammalian optic chiasm: growth cone guidance using intrinsic chiasm cues. Neuron. 1993 Apr; 10(4):761-77. PMID: 8386532.
      View in: PubMed
    37. Sretavan D. Pathfinding at the mammalian optic chiasm. Curr Opin Neurobiol. 1993 Feb; 3(1):45-52. PMID: 8453289.
      View in: PubMed
    38. Reichardt LF, Bossy B, de Curtis I, Neugebauer KM, Venstrom K, Sretavan D. Adhesive interactions that regulate development of the retina and primary visual projection. Cold Spring Harb Symp Quant Biol. 1992; 57:419-29. PMID: 1339677.
      View in: PubMed
    39. Sretavan D. Specific routing of retinal ganglion cell axons at the mammalian optic chiasm during embryonic development. J Neurosci. 1990 Jun; 10(6):1995-2007. PMID: 2162389.
      View in: PubMed
    40. Sretavan D, Shatz CJ, Stryker MP. Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin. Nature. 1988 Dec 1; 336(6198):468-71. PMID: 2461517.
      View in: PubMed
    41. Garraghty PE, Shatz CJ, Sretavan D, Sur M. Axon arbors of X and Y retinal ganglion cells are differentially affected by prenatal disruption of binocular inputs. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7361-5. PMID: 3174640; PMCID: PMC282186.
      View in: PubMed, PubMed Central
    42. Sretavan D, Shatz CJ. Axon trajectories and pattern of terminal arborization during the prenatal development of the cat's retinogeniculate pathway. J Comp Neurol. 1987 Jan 15; 255(3):386-400. PMID: 3819020.
      View in: PubMed
    43. Sretavan D, Shatz CJ. Prenatal development of cat retinogeniculate axon arbors in the absence of binocular interactions. J Neurosci. 1986 Apr; 6(4):990-1003. PMID: 3701418.
      View in: PubMed
    44. Shatz CJ, Sretavan D. Interactions between retinal ganglion cells during the development of the mammalian visual system. Annu Rev Neurosci. 1986; 9:171-207. PMID: 2423004.
      View in: PubMed
    45. Sretavan D, Shatz CJ. Prenatal development of retinal ganglion cell axons: segregation into eye-specific layers within the cat's lateral geniculate nucleus. J Neurosci. 1986 Jan; 6(1):234-51. PMID: 3944621.
      View in: PubMed
    46. Sretavan D, Shatz CJ. Prenatal development of individual retinogeniculate axons during the period of segregation. Nature. 1984 Apr 26-May 2; 308(5962):845-8. PMID: 6201743.
      View in: PubMed
    47. Sretavan D, Dykes RW. The organization of two cutaneous submodalities in the forearm region of area 3b of cat somatosensory cortex. J Comp Neurol. 1983 Feb 1; 213(4):381-98. PMID: 6300198.
      View in: PubMed
    48. Dykes RW, Rasmusson DD, Sretavan D, Rehman NB. Submodality segregation and receptive-field sequences in cuneate, gracile, and external cuneate nuclei of the cat. J Neurophysiol. 1982 Mar; 47(3):389-416. PMID: 6461730.
      View in: PubMed
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