Michael Stryker, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Interneuron Precursors and the induction of cortical plasticity
    NIH/NEI R01EY025174Dec 2, 2014 - Nov 30, 2018
    Role: Co-Principal Investigator
    Forward Genetic Approaches to Mechanisms of Cortical Plasticity
    NIH/NIMH P50MH077972Apr 1, 2007 - Aug 31, 2012
    Role: Co-Investigator
    Functional Connectivity of Primary Visual Cortex
    NIH/NEI R01EY013595Aug 1, 2001 - Jun 30, 2007
    Role: Principal Investigator
    NIH/NINDS R01NS040245Sep 30, 1999 - Jun 30, 2002
    Role: Principal Investigator
    NIH/NEI R01EY009760Mar 1, 1993 - Feb 28, 1999
    Role: Principal Investigator
    NIH/NEI K04EY000213Jan 1, 1982 - Dec 31, 1986
    Role: Principal Investigator
    Function and development in the synapse
    NIH P01NS016033Apr 1, 1980 - Jun 30, 2009
    Role: Co-Investigator
    Development and plasticity of the visual system
    NIH/NEI R01EY002874Dec 1, 1978 - Aug 31, 2019
    Role: Principal Investigator
    NIH/NEI R37EY002874Dec 1, 1978 - Jun 30, 2007
    Role: Principal Investigator
    NIH/NINDS T32NS007067Jul 1, 1977 - Jun 30, 2004
    Role: Principal Investigator

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    Collapse Global Health
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Priya R, Rakela B, Kaneko M, Spatazza J, Larimer P, Hoseini MS, Hasenstaub AR, Alvarez-Buylla A, Stryker MP. Vesicular GABA transporter is necessary for transplant-induced critical period plasticity in mouse visual cortex. J Neurosci. 2019 Jan 31. PMID: 30705101.
      View in: PubMed
    2. Dyballa L, Hoseini MS, Dadarlat MC, Zucker SW, Stryker MP. Flow stimuli reveal ecologically appropriate responses in mouse visual cortex. Proc Natl Acad Sci U S A. 2018 10 30; 115(44):11304-11309. PMID: 30327345.
      View in: PubMed
    3. Stryker MP, Löwel S. Amblyopia: New molecular/pharmacological and environmental approaches. Vis Neurosci. 2018 01; 35:E018. PMID: 29905118.
      View in: PubMed
    4. Larimer P, Spatazza J, Stryker MP, Alvarez-Buylla A, Hasenstaub AR. Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment. J Neurophysiol. 2017 Jul 01; 118(1):131-139. PMID: 28356470.
      View in: PubMed
    5. Dadarlat MC, Stryker MP. Locomotion Enhances Neural Encoding of Visual Stimuli in Mouse V1. J Neurosci. 2017 04 05; 37(14):3764-3775. PMID: 28264980.
      View in: PubMed
    6. Fox K, Stryker M. Integrating Hebbian and homeostatic plasticity: introduction. Philos Trans R Soc Lond B Biol Sci. 2017 03 05; 372(1715). PMID: 28093560.
      View in: PubMed
    7. Kaneko M, Stryker MP. Homeostatic plasticity mechanisms in mouse V1. Philos Trans R Soc Lond B Biol Sci. 2017 03 05; 372(1715). PMID: 28093561.
      View in: PubMed
    8. Keck T, Toyoizumi T, Chen L, Doiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hübener M, Lee HK, Lisman JE, Rose T, Sengpiel F, Stellwagen D, Stryker MP, Turrigiano GG, van Rossum MC. Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philos Trans R Soc Lond B Biol Sci. 2017 03 05; 372(1715). PMID: 28093552.
      View in: PubMed
    9. Kaneko M, Fu Y, Stryker MP. Locomotion Induces Stimulus-Specific Response Enhancement in Adult Visual Cortex. J Neurosci. 2017 03 29; 37(13):3532-3543. PMID: 28258167.
      View in: PubMed
    10. Larimer P, Spatazza J, Espinosa JS, Tang Y, Kaneko M, Hasenstaub AR, Stryker MP, Alvarez-Buylla A. Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity. Cell Rep. 2016 08 02; 16(5):1391-1404. PMID: 27425623.
      View in: PubMed
    11. Zembrzycki A, Stocker AM, Leingärtner A, Sahara S, Chou SJ, Kalatsky V, May SR, Stryker MP, O'Leary DD. Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. Elife. 2015 Dec 24; 4. PMID: 26705332.
      View in: PubMed
    12. Owens MT, Feldheim DA, Stryker MP, Triplett JW. Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps. Neuron. 2015 Sep 23; 87(6):1261-1273. PMID: 26402608.
      View in: PubMed
    13. Stryker MP. A Neural Circuit That Controls Cortical State, Plasticity, and the Gain of Sensory Responses in Mouse. Cold Spring Harb Symp Quant Biol. 2014; 79:1-9. PMID: 25948638.
      View in: PubMed
    14. Barondes S, Stryker MP. Allison Doupe: in memoriam. Neuron. 2015 Feb 18; 85(4):667-8. PMID: 25848665.
      View in: PubMed
    15. Fu Y, Kaneko M, Tang Y, Alvarez-Buylla A, Stryker MP. A cortical disinhibitory circuit for enhancing adult plasticity. Elife. 2015 Jan 27; 4:e05558. PMID: 25626167.
      View in: PubMed
    16. Tang Y, Stryker MP, Alvarez-Buylla A, Espinosa JS. Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18339-44. PMID: 25489113.
      View in: PubMed
    17. Toyoizumi T, Kaneko M, Stryker MP, Miller KD. Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron. 2014 Oct 22; 84(2):497-510. PMID: 25374364.
      View in: PubMed
    18. Lee AM, Hoy JL, Bonci A, Wilbrecht L, Stryker MP, Niell CM. Identification of a brainstem circuit regulating visual cortical state in parallel with locomotion. Neuron. 2014 Jul 16; 83(2):455-466. PMID: 25033185.
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    19. Kaneko M, Stryker MP. Sensory experience during locomotion promotes recovery of function in adult visual cortex. Elife. 2014 Jun 26; 3:e02798. PMID: 24970838.
      View in: PubMed
    20. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622. PMID: 24723614.
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    21. Fu Y, Tucciarone JM, Espinosa JS, Sheng N, Darcy DP, Nicoll RA, Huang ZJ, Stryker MP. A cortical circuit for gain control by behavioral state. Cell. 2014 Mar 13; 156(6):1139-1152. PMID: 24630718.
      View in: PubMed
    22. Espinosa JS, Stryker MP. Development and plasticity of the primary visual cortex. Neuron. 2012 Jul 26; 75(2):230-49. PMID: 22841309; PMCID: PMC3612584.
    23. Kaneko M, Xie Y, An JJ, Stryker MP, Xu B. Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation. J Neurosci. 2012 Apr 04; 32(14):4790-802. PMID: 22492034; PMCID: PMC3356781.
    24. Cramer SC, Sur M, Dobkin BH, O'Brien C, Sanger TD, Trojanowski JQ, Rumsey JM, Hicks R, Cameron J, Chen D, Chen WG, Cohen LG, deCharms C, Duffy CJ, Eden GF, Fetz EE, Filart R, Freund M, Grant SJ, Haber S, Kalivas PW, Kolb B, Kramer AF, Lynch M, Mayberg HS, McQuillen PS, Nitkin R, Pascual-Leone A, Reuter-Lorenz P, Schiff N, Sharma A, Shekim L, Stryker M, Sullivan EV, Vinogradov S. Harnessing neuroplasticity for clinical applications. Brain. 2011 Jun; 134(Pt 6):1591-609. PMID: 21482550; PMCID: PMC3102236.
    25. Kaneko M, Cheetham CE, Lee YS, Silva AJ, Stryker MP, Fox K. Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):19026-31. PMID: 20937865; PMCID: PMC2973899.
    26. Sato M, Stryker MP. Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5611-6. PMID: 20212164; PMCID: PMC2851788.
    27. Southwell DG, Froemke RC, Alvarez-Buylla A, Stryker MP, Gandhi SP. Cortical plasticity induced by inhibitory neuron transplantation. Science. 2010 Feb 26; 327(5969):1145-8. PMID: 20185728; PMCID: PMC3164148.
    28. Niell CM, Stryker MP. Modulation of visual responses by behavioral state in mouse visual cortex. Neuron. 2010 Feb 25; 65(4):472-9. PMID: 20188652; PMCID: PMC3184003.
    29. Failor S, Nguyen V, Darcy DP, Cang J, Wendland MF, Stryker MP, McQuillen PS. Neonatal cerebral hypoxia-ischemia impairs plasticity in rat visual cortex. J Neurosci. 2010 Jan 06; 30(1):81-92. PMID: 20053890; PMCID: PMC2822440.
    30. Triplett JW, Owens MT, Yamada J, Lemke G, Cang J, Stryker MP, Feldheim DA. Retinal input instructs alignment of visual topographic maps. Cell. 2009 Oct 02; 139(1):175-85. PMID: 19804762; PMCID: PMC2814139.
    31. Ehninger D, Li W, Fox K, Stryker MP, Silva AJ. Reversing neurodevelopmental disorders in adults. Neuron. 2008 Dec 26; 60(6):950-60. PMID: 19109903; PMCID: PMC2710296.
    32. Cang J, Wang L, Stryker MP, Feldheim DA. Roles of ephrin-as and structured activity in the development of functional maps in the superior colliculus. J Neurosci. 2008 Oct 22; 28(43):11015-23. PMID: 18945909; PMCID: PMC2588436.
    33. Gandhi SP, Yanagawa Y, Stryker MP. Delayed plasticity of inhibitory neurons in developing visual cortex. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16797-802. PMID: 18940923; PMCID: PMC2575499.
    34. Sato M, Stryker MP. Distinctive features of adult ocular dominance plasticity. J Neurosci. 2008 Oct 08; 28(41):10278-86. PMID: 18842887; PMCID: PMC2851628.
    35. Niell CM, Stryker MP. Highly selective receptive fields in mouse visual cortex. J Neurosci. 2008 Jul 23; 28(30):7520-36. PMID: 18650330; PMCID: PMC3040721.
    36. Kaneko M, Stellwagen D, Malenka RC, Stryker MP. Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. Neuron. 2008 Jun 12; 58(5):673-80. PMID: 18549780; PMCID: PMC2884387.
    37. Sharpee TO, Miller KD, Stryker MP. On the importance of static nonlinearity in estimating spatiotemporal neural filters with natural stimuli. J Neurophysiol. 2008 May; 99(5):2496-509. PMID: 18353910; PMCID: PMC2877595.
    38. Kaneko M, Hanover JL, England PM, Stryker MP. TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation. Nat Neurosci. 2008 Apr; 11(4):497-504. PMID: 18311133; PMCID: PMC2413329.
    39. Cang J, Niell CM, Liu X, Pfeiffenberger C, Feldheim DA, Stryker MP. Selective disruption of one Cartesian axis of cortical maps and receptive fields by deficiency in ephrin-As and structured activity. Neuron. 2008 Feb 28; 57(4):511-23. PMID: 18304481; PMCID: PMC2413327.
    40. Jin JZ, Weng C, Yeh CI, Gordon JA, Ruthazer ES, Stryker MP, Swadlow HA, Alonso JM. On and off domains of geniculate afferents in cat primary visual cortex. Nat Neurosci. 2008 Jan; 11(1):88-94. PMID: 18084287; PMCID: PMC2556869.
    41. Rentería RC, Tian N, Cang J, Nakanishi S, Stryker MP, Copenhagen DR. Intrinsic ON responses of the retinal OFF pathway are suppressed by the ON pathway. J Neurosci. 2006 Nov 15; 26(46):11857-69. PMID: 17108159; PMCID: PMC2553694.
    42. Sharpee TO, Sugihara H, Kurgansky AV, Rebrik SP, Stryker MP, Miller KD. Adaptive filtering enhances information transmission in visual cortex. Nature. 2006 Feb 23; 439(7079):936-42. PMID: 16495990; PMCID: PMC2562720.
    43. Lee TT, Levi O, Cang J, Kaneko M, Stryker MP, Smith SJ, Shenoy KV, Harris JS. Integrated semiconductor optical sensors for chronic, minimally-invasive imaging of brain function. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1025-8. PMID: 17946016; PMCID: PMC2562279.
    44. Cang J, Rentería RC, Kaneko M, Liu X, Copenhagen DR, Stryker MP. Development of precise maps in visual cortex requires patterned spontaneous activity in the retina. Neuron. 2005 Dec 08; 48(5):797-809. PMID: 16337917; PMCID: PMC2562716.
    45. Cang J, Kaneko M, Yamada J, Woods G, Stryker MP, Feldheim DA. Ephrin-as guide the formation of functional maps in the visual cortex. Neuron. 2005 Nov 23; 48(4):577-89. PMID: 16301175; PMCID: PMC2424263.
    46. Taha SA, Stryker MP. Ocular dominance plasticity is stably maintained in the absence of alpha calcium calmodulin kinase II (alphaCaMKII) autophosphorylation. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16438-42. PMID: 16260732; PMCID: PMC1283462.
    47. Cang J, Kalatsky VA, Löwel S, Stryker MP. Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse. Vis Neurosci. 2005 Sep-Oct; 22(5):685-91. PMID: 16332279; PMCID: PMC2553096.
    48. Kalatsky VA, Polley DB, Merzenich MM, Schreiner CE, Stryker MP. Fine functional organization of auditory cortex revealed by Fourier optical imaging. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13325-30. PMID: 16141342; PMCID: PMC1201601.
    49. Taha SA, Stryker MP. Molecular substrates of plasticity in the developing visual cortex. Prog Brain Res. 2005; 147:103-14. PMID: 15581700.
      View in: PubMed
    50. Gandhi SP, Cang J, Stryker MP. An eye-opening experience. Nat Neurosci. 2005 Jan; 8(1):9-10. PMID: 15622410; PMCID: PMC2413328.
    51. Hensch TK, Stryker MP. Columnar architecture sculpted by GABA circuits in developing cat visual cortex. Science. 2004 Mar 12; 303(5664):1678-81. PMID: 15017001; PMCID: PMC2562723.
    52. Kalatsky VA, Stryker MP. New paradigm for optical imaging: temporally encoded maps of intrinsic signal. Neuron. 2003 May 22; 38(4):529-45. PMID: 12765606.
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    53. Frank MG, Stryker MP, Tecott LH. Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor. Neuropsychopharmacology. 2002 Nov; 27(5):869-73. PMID: 12431861; PMCID: PMC2452994.
    54. Taha S, Hanover JL, Silva AJ, Stryker MP. Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity. Neuron. 2002 Oct 24; 36(3):483-91. PMID: 12408850.
      View in: PubMed
    55. Taha S, Stryker MP. Rapid ocular dominance plasticity requires cortical but not geniculate protein synthesis. Neuron. 2002 Apr 25; 34(3):425-36. PMID: 11988173.
      View in: PubMed
    56. Stryker MP, Antonini A. Factors shaping the corpus callosum. J Comp Neurol. 2001 May 14; 433(4):437-40. PMID: 11304709.
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    57. Stryker MP. Neuroscience. Drums keep pounding a rhythm in the brain. Science. 2001 Feb 23; 291(5508):1506-7. PMID: 11234083; PMCID: PMC2866371.