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John Rubenstein

TitleProfessor
SchoolUCSF School of Medicine
DepartmentPsychiatry
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-476-7862
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    Collapse Biography 
    Collapse Education and Training
    StanfordBS1977Chemistry
    StanfordBiophysics1982Membrane Structure and Biogenesis
    StanfordMD1986
    Pasteur Institute, ParisPostdoc1986Mouse Embryology
    StanfordResidency1991Psychiatry

    Collapse Research 
    Collapse Research Activities and Funding
    Genetic Studies of Cortex Structure and Development
    NIH/NINDS R01NS099099Sep 30, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Identification of enhancers whose activity defines cortical interneuron types
    NIH/NIMH U01MH105948Sep 26, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Genetic Control of Basal Telencephalic Development
    NIH/NIMH R01MH081880Dec 1, 2007 - Jan 31, 2019
    Role: Principal Investigator
    Genetic Regulation of Telencephalon Development
    NIH/NIMH K05MH065670Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator
    Regulation of craniofacial development by the Dix genes.
    NIH/NIDCD R01DC005667Jan 1, 2003 - Dec 31, 2007
    Role: Principal Investigator
    NKX HOMEOBOX GENE REGULATION OF VENTRAL CNS DEVELOPMENT
    NIH/NIDA R01DA012462May 1, 1999 - Feb 28, 2005
    Role: Principal Investigator
    Genetic Studies of Cortex Structure and Development
    NIH/NINDS R01NS034661Sep 1, 1996 - Jan 31, 2016
    Role: Principal Investigator
    FUNCTION OF DLX GENES IN FOREBRAIN DEVELOPMENT
    NIH/NIMH R01MH051561Sep 30, 1994 - May 31, 2003
    Role: Principal Investigator
    GENETIC REGULATION OF TELENCEPHALON DEVELOPMENT
    NIH/NIMH K02MH001046Jan 1, 1993 - Dec 31, 2002
    Role: Principal Investigator
    Genetic Regulation of Telencephalon Development
    NIH/NIMH R37MH049428Jun 1, 1992 - Nov 30, 2017
    Role: Principal Investigator
    Genetic Regulation of Telencephalon Development
    NIH/NIMH R01MH049428Jun 1, 1992 - Nov 30, 2007
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wu PR, Cho KK, Vogt D, Sohal VS, Rubenstein J. The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex. Cereb Cortex. 2017 Sep 01; 27(9):4303-4313. PMID: 27497284.
      View in: PubMed
    2. Le TN, Zhou QP, Cobos I, Zhang S, Zagozewski J, Japoni S, Vriend J, Parkinson T, Du G, Rubenstein J, Eisenstat DD. GABAergic Interneuron Differentiation in the Basal Forebrain Is Mediated through Direct Regulation of Glutamic Acid Decarboxylase Isoforms by Dlx Homeobox Transcription Factors. J Neurosci. 2017 Sep 06; 37(36):8816-8829. PMID: 28821666.
      View in: PubMed
    3. Hu JS, Vogt D, Lindtner S, Sandberg M, Silberberg SN, Rubenstein J. Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons. Development. 2017 Aug 01; 144(15):2837-2851. PMID: 28694260.
      View in: PubMed
    4. Yang N, Chanda S, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein J, Chang HY, Buylla AA, Südhof TC, Wernig M. Generation of pure GABAergic neurons by transcription factor programming. Nat Methods. 2017 Jun; 14(6):621-628. PMID: 28504679.
      View in: PubMed
    5. Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein J, Oldham MC. Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity. Cereb Cortex. 2017 Apr 26; 1-13. PMID: 28449024.
      View in: PubMed
    6. Chen YJ, Friedman BA, Ha C, Durinck S, Liu J, Rubenstein J, Seshagiri S, Modrusan Z. Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. Sci Rep. 2017 Mar 31; 7:45656. PMID: 28361918.
      View in: PubMed
    7. Gobius I, Morcom L, Suárez R, Bunt J, Bukshpun P, Reardon W, Dobyns WB, Rubenstein J, Barkovich AJ, Sherr EH, Richards LJ. Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum. Cell Rep. 2016 Oct 11; 17(3):735-747. PMID: 27732850.
      View in: PubMed
    8. Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein J. Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate. Neuron. 2016 Oct 05; 92(1):59-74. PMID: 27710791.
      View in: PubMed
    9. Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein J. Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron. 2016 Sep 21; 91(6):1260-1275. PMID: 27657450.
      View in: PubMed
    10. Sun Y, Pasca SP, Portmann T, Goold C, Worringer KA, Guan W, Chan KC, Gai H, Vogt D, Chen YJ, Mao R, Chan K, Rubenstein J, Madison DV, Hallmayer J, Froehlich-Santino WM, Bernstein JA, Dolmetsch RE. A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients. Elife. 2016 Jul 26; 5. PMID: 27458797; PMCID: PMC4961470.
    11. Zhang Q, Zhang Y, Wang C, Xu Z, Liang Q, An L, Li J, Liu Z, You Y, He M, Mao Y, Chen B, Xiong ZQ, Rubenstein J, Yang Z. The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons. Cell Rep. 2016 Aug 2; 16(5):1431-44. PMID: 27452460.
      View in: PubMed
    12. Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein J, McConnell SK, Chen B, Bejerano G. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016 08; 26(8):1013-22. PMID: 27325115; PMCID: PMC4971772 [Available on 02/01/17].
    13. Puelles L, Medina L, Borello U, Legaz I, Teissier A, Pierani A, Rubenstein J. Radial derivatives of the mouse ventral pallium traced with Dbx1-LacZ reporters. J Chem Neuroanat. 2016 Sep; 75(Pt A):2-19. PMID: 26748312.
      View in: PubMed
    14. Holloway AK, Bruneau BG, Sukonnik T, Rubenstein J, Pollard KS. Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor. Mol Biol Evol. 2016 Apr; 33(4):1008-18. PMID: 26715627; PMCID: PMC4776709.
    15. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, Shimogori T, Sedlacek R, Rubenstein J, Wittmann T, Klein OD. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24. PMID: 26702830; PMCID: PMC4710359 [Available on 12/21/16].
    16. Golonzhka O, Nord A, Tang PL, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein J. Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16; 88(6):1192-207. PMID: 26671461; PMCID: PMC4688141 [Available on 12/16/16].
    17. Lim JW, Donahoo AL, Bunt J, Edwards TJ, Fenlon LR, Liu Y, Zhou J, Moldrich RX, Piper M, Gobius I, Bailey TL, Wray NR, Kessaris N, Poo MM, Rubenstein J, Richards LJ. EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development. 2015 Nov 01; 142(21):3746-57. PMID: 26534986; PMCID: PMC4647209 [Available on 11/01/16].
    18. Martinez-Ferre A, Lloret-Quesada C, Prakash N, Wurst W, Rubenstein J, Martinez S. Fgf15 regulates thalamic development by controlling the expression of proneural genes. Brain Struct Funct. 2016 Jul; 221(6):3095-109. PMID: 26311466.
      View in: PubMed
    19. Ypsilanti AR, Rubenstein J. Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development. J Comp Neurol. 2016 Feb 15; 524(3):609-29. PMID: 26304102; PMCID: PMC4706819 [Available on 02/15/17].
    20. Parchem RJ, Moore N, Fish JL, Parchem JG, Braga TT, Shenoy A, Oldham MC, Rubenstein J, Schneider RA, Blelloch R. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep. 2015 Aug 04; 12(5):760-73. PMID: 26212322; PMCID: PMC4741278.
    21. Hoch RV, Lindtner S, Price JD, Rubenstein J. OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21; 12(3):482-94. PMID: 26166575; PMCID: PMC4512845.
    22. Cesario JM, Landin Malt A, Deacon LJ, Sandberg M, Vogt D, Tang Z, Zhao Y, Brown S, Rubenstein J, Jeong J. Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet. 2015 Sep 01; 24(17):5024-39. PMID: 26071365; PMCID: PMC4527495.
    23. Bráz JM, Wang X, Guan Z, Rubenstein J, Basbaum AI. Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Pain. 2015 Jun; 156(6):1084-91. PMID: 25760475; PMCID: PMC4431911.
    24. Eckler MJ, Nguyen TD, McKenna WL, Fastow BL, Guo C, Rubenstein J, Chen B. Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia. Neuron. 2015 May 20; 86(4):1100-1108. PMID: 25996137; PMCID: PMC4441766.
    25. Vogt D, Cho KK, Lee AT, Sohal VS, Rubenstein J. The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. Cell Rep. 2015 May 12; 11(6):944-956. PMID: 25937288; PMCID: PMC4431948.
    26. Vogt D, Wu PR, Sorrells SF, Arnold C, Alvarez-Buylla A, Rubenstein J. Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies. J Vis Exp. 2015 Apr 23; (98). PMID: 25938985; PMCID: PMC4541591.
    27. Ferran JL, Puelles L, Rubenstein J. Molecular codes defining rostrocaudal domains in the embryonic mouse hypothalamus. Front Neuroanat. 2015; 9:46. PMID: 25941476; PMCID: PMC4400913.
    28. Hoch RV, Clarke JA, Rubenstein J. Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center. Neural Dev. 2015 Mar 31; 10:8. PMID: 25889070; PMCID: PMC4416298.
    29. Puelles L, Rubenstein J. A new scenario of hypothalamic organization: rationale of new hypotheses introduced in the updated prosomeric model. Front Neuroanat. 2015; 9:27. PMID: 25852489; PMCID: PMC4365718.
    30. Cho KK, Hoch R, Lee AT, Patel T, Rubenstein J, Sohal VS. Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice. Neuron. 2015 Mar 18; 85(6):1332-43. PMID: 25754826; PMCID: PMC4503262.
    31. Nord AS, Pattabiraman K, Visel A, Rubenstein J. Genomic perspectives of transcriptional regulation in forebrain development. Neuron. 2015 Jan 07; 85(1):27-47. PMID: 25569346; PMCID: PMC4438709.
    32. Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein J, Ingraham HA. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 06; 10(1):62-74. PMID: 25543145; PMCID: PMC4324838.
    33. Eom TY, Stanco A, Guo J, Wilkins G, Deslauriers D, Yan J, Monckton C, Blair J, Oon E, Perez A, Salas E, Oh A, Ghukasyan V, Snider WD, Rubenstein J, Anton ES. Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration. Dev Cell. 2014 Dec 22; 31(6):677-89. PMID: 25535916; PMCID: PMC4289145.
    34. Stanco A, Pla R, Vogt D, Chen Y, Mandal S, Walker J, Hunt RF, Lindtner S, Erdman CA, Pieper AA, Hamilton SP, Xu D, Baraban SC, Rubenstein J. NPAS1 represses the generation of specific subtypes of cortical interneurons. Neuron. 2014 Dec 03; 84(5):940-53. PMID: 25467980; PMCID: PMC4258152.
    35. Lee AT, Vogt D, Rubenstein J, Sohal VS. A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior. J Neurosci. 2014 Aug 27; 34(35):11519-25. PMID: 25164650; PMCID: PMC4145166.
    36. Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein J, Alvarez-Buylla A, Huang Y. Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aß accumulation. J Neurosci. 2014 Jul 16; 34(29):9506-15. PMID: 25031394; PMCID: PMC4099537.
    37. Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein J, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16; 83(2):309-323. PMID: 24952961; PMCID: PMC4319559.
    38. Rubenstein J. Major progress towards elucidating brain wiring diagrams. J Comp Neurol. 2014 Jun 15; 522(9):1987-8. PMID: 24752413.
      View in: PubMed
    39. Pattabiraman K, Golonzhka O, Lindtner S, Nord AS, Taher L, Hoch R, Silberberg SN, Zhang D, Chen B, Zeng H, Pennacchio LA, Puelles L, Visel A, Rubenstein J. Transcriptional regulation of enhancers active in protodomains of the developing cerebral cortex. Neuron. 2014 Jun 04; 82(5):989-1003. PMID: 24814534; PMCID: PMC4104757.
    40. Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T, Yang Z, Baraban SC, Rubenstein J. Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron. 2014 Apr 16; 82(2):350-64. PMID: 24742460; PMCID: PMC4261952.
    41. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein J, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622. PMID: 24723614; PMCID: PMC4056344.
    42. Eckler MJ, Larkin KA, McKenna WL, Katzman S, Guo C, Roque R, Visel A, Rubenstein J, Chen B. Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. Neural Dev. 2014 Mar 12; 9:6. PMID: 24618363; PMCID: PMC4008173.
    43. Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein J, Rowitch DH. Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 05; 81(3):574-87. PMID: 24507192; PMCID: PMC3979971.
    44. Nord AS, Blow MJ, Attanasio C, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Rubenstein J, Rubin EM, Pennacchio LA, Visel A. Rapid and pervasive changes in genome-wide enhancer usage during mammalian development. Cell. 2013 Dec 19; 155(7):1521-31. PMID: 24360275; PMCID: PMC3989111.
    45. Lee AT, Gee SM, Vogt D, Patel T, Rubenstein J, Sohal VS. Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Neuron. 2014 Jan 08; 81(1):61-8. PMID: 24361076; PMCID: PMC3947199.
    46. Howard MA, Rubenstein J, Baraban SC. Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):492-7. PMID: 24344303; PMCID: PMC3890856.
    47. Guo C, Eckler MJ, McKenna WL, McKinsey GL, Rubenstein J, Chen B. Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes. Neuron. 2013 Dec 04; 80(5):1167-74. PMID: 24314728; PMCID: PMC3857588.
    48. Capra JA, Erwin GD, McKinsey G, Rubenstein J, Pollard KS. Many human accelerated regions are developmental enhancers. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 19; 368(1632):20130025. PMID: 24218637; PMCID: PMC3826498.
    49. Mandal S, Stanco A, Buys ES, Enikolopov G, Rubenstein J. Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. J Neurosci. 2013 Oct 23; 33(43):16897-914. PMID: 24155296; PMCID: PMC3866415.
    50. Zhao Y, Flandin P, Vogt D, Blood A, Hermesz E, Westphal H, Rubenstein J. Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol. 2014 Jan 01; 385(1):94-106. PMID: 24157949; PMCID: PMC3882892.
    51. Hansen DV, Lui JH, Flandin P, Yoshikawa K, Rubenstein J, Alvarez-Buylla A, Kriegstein AR. Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences. Nat Neurosci. 2013 Nov; 16(11):1576-87. PMID: 24097039; PMCID: PMC4191718.
    52. Ma T, Wang C, Wang L, Zhou X, Tian M, Zhang Q, Zhang Y, Li J, Liu Z, Cai Y, Liu F, You Y, Chen C, Campbell K, Song H, Ma L, Rubenstein J, Yang Z. Subcortical origins of human and monkey neocortical interneurons. Nat Neurosci. 2013 Nov; 16(11):1588-97. PMID: 24097041.
      View in: PubMed
    53. Arguello A, Yang X, Vogt D, Stanco A, Rubenstein J, Cheyette BN. Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS One. 2013; 8(6):e67679. PMID: 23826333; PMCID: PMC3691262.
    54. Cai Y, Zhang Y, Shen Q, Rubenstein J, Yang Z. A subpopulation of individual neural progenitors in the mammalian dorsal pallium generates both projection neurons and interneurons in vitro. Stem Cells. 2013 Jun; 31(6):1193-201. PMID: 23417928.
      View in: PubMed
    55. Hunt RF, Girskis KM, Rubenstein J, Alvarez-Buylla A, Baraban SC. GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior. Nat Neurosci. 2013 Jun; 16(6):692-7. PMID: 23644485; PMCID: PMC3665733.
    56. Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 02; 92(5):725-43. PMID: 23643382; PMCID: PMC3644636.
    57. Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein J, Kriegstein AR. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell. 2013 May 02; 12(5):573-86. PMID: 23642366; PMCID: PMC3699205.
    58. Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein J. Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013 May 01; 521(7):1561-84. PMID: 23042297; PMCID: PMC3615175.
    59. Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein J. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. PLoS One. 2013; 8(5):e61956. PMID: 23658702; PMCID: PMC3641041.
    60. Tabarés-Seisdedos R, Rubenstein J. Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders. Nat Rev Neurosci. 2013 Apr; 14(4):293-304. PMID: 23511909.
      View in: PubMed
    61. Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein J, Pleasure SJ. CoupTFI interacts with retinoic acid signaling during cortical development. PLoS One. 2013; 8(3):e58219. PMID: 23472160; PMCID: PMC3589372.
    62. DeFelipe J, López-Cruz PL, Benavides-Piccione R, Bielza C, Larrañaga P, Anderson S, Burkhalter A, Cauli B, Fairén A, Feldmeyer D, Fishell G, Fitzpatrick D, Freund TF, González-Burgos G, Hestrin S, Hill S, Hof PR, Huang J, Jones EG, Kawaguchi Y, Kisvárday Z, Kubota Y, Lewis DA, Marín O, Markram H, McBain CJ, Meyer HS, Monyer H, Nelson SB, Rockland K, Rossier J, Rubenstein J, Rudy B, Scanziani M, Shepherd GM, Sherwood CC, Staiger JF, Tamás G, Thomson A, Wang Y, Yuste R, Ascoli GA. New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci. 2013 03; 14(3):202-16. PMID: 23385869; PMCID: PMC3619199.
    63. Cai Y, Zhang Q, Wang C, Zhang Y, Ma T, Zhou X, Tian M, Rubenstein J, Yang Z. Nuclear receptor COUP-TFII-expressing neocortical interneurons are derived from the medial and lateral/caudal ganglionic eminence and define specific subsets of mature interneurons. J Comp Neurol. 2013 Feb 01; 521(2):479-97. PMID: 22791192.
      View in: PubMed
    64. Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch RV, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Kaplan T, Kriegstein AR, Rubin EM, Ovcharenko I, Pennacchio LA, Rubenstein J. A high-resolution enhancer atlas of the developing telencephalon. Cell. 2013 Feb 14; 152(4):895-908. PMID: 23375746; PMCID: PMC3660042.
    65. Borello U, Madhavan M, Vilinsky I, Faedo A, Pierani A, Rubenstein J, Campbell K. Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors. Cereb Cortex. 2014 Jun; 24(6):1409-21. PMID: 23307639; PMCID: PMC4014177.
    66. McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio LA, Huylebroeck D, Higashi Y, Rubenstein J. Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron. 2013 Jan 09; 77(1):83-98. PMID: 23312518; PMCID: PMC3547499.
    67. Southwell DG, Paredes MF, Galvao RP, Jones DL, Froemke RC, Sebe JY, Alfaro-Cervello C, Tang Y, Garcia-Verdugo JM, Rubenstein J, Baraban SC, Alvarez-Buylla A. Intrinsically determined cell death of developing cortical interneurons. Nature. 2012 Nov 01; 491(7422):109-13. PMID: 23041929; PMCID: PMC3726009.
    68. Jeong J, Cesario J, Zhao Y, Burns L, Westphal H, Rubenstein J. Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn. 2012 Nov; 241(11):1757-69. PMID: 22972697; PMCID: PMC3988582.
    69. Li Y, Yui D, Luikart BW, McKay RM, Li Y, Rubenstein J, Parada LF. Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15491-6. PMID: 22949667; PMCID: PMC3458400.
    70. Delogu A, Sellers K, Zagoraiou L, Bocianowska-Zbrog A, Mandal S, Guimera J, Rubenstein J, Sugden D, Jessell T, Lumsden A. Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron. 2012 Aug 23; 75(4):648-62. PMID: 22920256.
      View in: PubMed
    71. Han S, Tai C, Westenbroek RE, Yu FH, Cheah CS, Potter GB, Rubenstein J, Scheuer T, de la Iglesia HO, Catterall WA. Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature. 2012 Sep 20; 489(7416):385-90. PMID: 22914087; PMCID: PMC3448848.
    72. Cheah CS, Yu FH, Westenbroek RE, Kalume FK, Oakley JC, Potter GB, Rubenstein J, Catterall WA. Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14646-51. PMID: 22908258; PMCID: PMC3437823.
    73. Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein J, Kreitzer AC, Huang Y. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS One. 2012; 7(7):e40555. PMID: 22792368; PMCID: PMC3390383.
    74. Seybold BA, Stanco A, Cho KK, Potter GB, Kim C, Sohal VS, Rubenstein J, Schreiner CE. Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13829-34. PMID: 22753490; PMCID: PMC3427089.
    75. Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein J, Basbaum AI. Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain. Neuron. 2012 May 24; 74(4):663-75. PMID: 22632725; PMCID: PMC3361692.
    76. Tang K, Rubenstein J, Tsai SY, Tsai MJ. COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 2012 May; 139(9):1630-9. PMID: 22492355; PMCID: PMC3317968.
    77. Sanchez-Ortiz E, Yui D, Song D, Li Y, Rubenstein J, Reichardt LF, Parada LF. TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci. 2012 Mar 21; 32(12):4065-79. PMID: 22442072; PMCID: PMC3403817.
    78. Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein J, Canals JM. Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons. Stem Cells Dev. 2012 Aug 10; 21(12):2239-51. PMID: 22142223; PMCID: PMC3411368.
    79. Ma T, Zhang Q, Cai Y, You Y, Rubenstein J, Yang Z. A subpopulation of dorsal lateral/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8. Cereb Cortex. 2012 Sep; 22(9):2120-30. PMID: 22021915.
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    81. Mao R, Schummers J, Knoblich U, Lacey CJ, Van Wart A, Cobos I, Kim C, Huguenard JR, Rubenstein J, Sur M. Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex. Cereb Cortex. 2012 Mar; 22(3):493-508. PMID: 21666125; PMCID: PMC3278313.
    82. Flandin P, Zhao Y, Vogt D, Jeong J, Long J, Potter G, Westphal H, Rubenstein J. Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron. 2011 Jun 09; 70(5):939-50. PMID: 21658586; PMCID: PMC3153409.
    83. Hansen DV, Rubenstein J, Kriegstein AR. Deriving excitatory neurons of the neocortex from pluripotent stem cells. Neuron. 2011 May 26; 70(4):645-60. PMID: 21609822; PMCID: PMC3124445.
    84. Tabarés-Seisdedos R, Dumont N, Baudot A, Valderas JM, Climent J, Valencia A, Crespo-Facorro B, Vieta E, Gómez-Beneyto M, Martínez S, Rubenstein J. No paradox, no progress: inverse cancer comorbidity in people with other complex diseases. Lancet Oncol. 2011 Jun; 12(6):604-8. PMID: 21498115.
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    85. Jones DL, Howard MA, Stanco A, Rubenstein J, Baraban SC. Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. J Neurophysiol. 2011 May; 105(5):1984-91. PMID: 21325686; PMCID: PMC3094166.
    86. Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein J, Sasai Y. Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. J Neurosci. 2011 Feb 02; 31(5):1919-33. PMID: 21289201.
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    87. Wang Y, Li G, Stanco A, Long JE, Crawford D, Potter GB, Pleasure SJ, Behrens T, Rubenstein J. CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron. 2011 Jan 13; 69(1):61-76. PMID: 21220099; PMCID: PMC3025760.
    88. McKenna WL, Betancourt J, Larkin KA, Abrams B, Guo C, Rubenstein J, Chen B. Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development. J Neurosci. 2011 Jan 12; 31(2):549-64. PMID: 21228164; PMCID: PMC3276402.
    89. Sajan SA, Rubenstein J, Warchol ME, Lovett M. Identification of direct downstream targets of Dlx5 during early inner ear development. Hum Mol Genet. 2011 Apr 01; 20(7):1262-73. PMID: 21227998; PMCID: PMC3049351.
    90. Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein J, Matise MP, Arnold HH, Jessell TM, Ericson J. A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 2010 Dec; 137(23):4051-60. PMID: 21062862.
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    91. Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein J, Noebels JL, Rosenmund C, Zoghbi HY. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11; 468(7321):263-9. PMID: 21068835; PMCID: PMC3057962.
    92. Rubenstein J. Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders. J Child Psychol Psychiatry. 2011 Apr; 52(4):339-55. PMID: 20735793; PMCID: PMC3429600.
    93. Poitras L, Yu M, Lesage-Pelletier C, Macdonald RB, Gagné JP, Hatch G, Kelly I, Hamilton SP, Rubenstein J, Poirier GG, Ekker M. An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain. Development. 2010 Sep; 137(18):3089-97. PMID: 20702565; PMCID: PMC3188590.
    94. Kaneko N, Marín O, Koike M, Hirota Y, Uchiyama Y, Wu JY, Lu Q, Tessier-Lavigne M, Alvarez-Buylla A, Okano H, Rubenstein J, Sawamoto K. New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron. 2010 Jul 29; 67(2):213-23. PMID: 20670830; PMCID: PMC4080818.
    95. Bedogni F, Hodge RD, Elsen GE, Nelson BR, Daza RA, Beyer RP, Bammler TK, Rubenstein J, Hevner RF. Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13129-34. PMID: 20615956; PMCID: PMC2919950.
    96. Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein J. Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14; 30(15):5334-45. PMID: 20392955; PMCID: PMC2919857.
    97. Rubenstein J. Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder. Curr Opin Neurol. 2010 Apr; 23(2):118-23. PMID: 20087182.
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    98. Moldrich RX, Pannek K, Hoch R, Rubenstein J, Kurniawan ND, Richards LJ. Comparative mouse brain tractography of diffusion magnetic resonance imaging. Neuroimage. 2010 Jul 01; 51(3):1027-36. PMID: 20303410; PMCID: PMC2882245.
    99. Faedo A, Borello U, Rubenstein J. Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times. J Neurosci. 2010 Mar 17; 30(11):4015-23. PMID: 20237272; PMCID: PMC2852648.
    100. Maira M, Long JE, Lee AY, Rubenstein J, Stifani S. Erratum to: Role for TGF-ß superfamily signaling in telencephalic GABAergic neuron development. J Neurodev Disord. 2010 Mar; 2(1):47. PMID: 22127839; PMCID: PMC3164029.
    101. Flandin P, Kimura S, Rubenstein J. The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci. 2010 Feb 24; 30(8):2812-23. PMID: 20181579; PMCID: PMC2865856.
    102. Martín-Ibáñez R, Crespo E, Urbán N, Sergent-Tanguy S, Herranz C, Jaumot M, Valiente M, Long JE, Pineda JR, Andreu C, Rubenstein J, Marín O, Georgopoulos K, Mengod G, Fariñas I, Bachs O, Alberch J, Canals JM. Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons. J Comp Neurol. 2010 Feb 01; 518(3):329-51. PMID: 19950118.
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    103. Endoh-Yamagami S, Karkar KM, May SR, Cobos I, Thwin MT, Long JE, Ashique AM, Zarbalis K, Rubenstein J, Peterson AS. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Dev Biol. 2010 Apr 01; 340(1):41-53. PMID: 20096683.
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    104. Han J, Mayo J, Xu X, Li J, Bringas P, Maas RL, Rubenstein J, Chai Y. Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec; 136(24):4225-33. PMID: 19934017; PMCID: PMC2781056.
    105. Maira M, Long JE, Lee AY, Rubenstein J, Stifani S. Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. J Neurodev Disord. 2010 Mar; 2(1):48-60. PMID: 20339443.
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    106. Yee CL, Wang Y, Anderson S, Ekker M, Rubenstein J. Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice. J Comp Neurol. 2009 Nov 01; 517(1):37-50. PMID: 19711380; PMCID: PMC3021751.
    107. Baraban SC, Southwell DG, Estrada RC, Jones DL, Sebe JY, Alfaro-Cervello C, García-Verdugo JM, Rubenstein J, Alvarez-Buylla A. Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15472-7. PMID: 19706400; PMCID: PMC2741275.
    108. Winden KD, Oldham MC, Mirnics K, Ebert PJ, Swan CH, Levitt P, Rubenstein J, Horvath S, Geschwind DH. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol. 2009; 5:291. PMID: 19638972; PMCID: PMC2724976.
    109. Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein J, Sur M. Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons. J Neurodev Disord. 2009 Sep; 1(3):224-36. PMID: 19816534.
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    110. Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein J, Livesey FJ. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun; 5(6):e1000511. PMID: 19521500; PMCID: PMC2686252.
    111. Long JE, Cobos I, Potter GB, Rubenstein J. Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex. 2009 Jul; 19 Suppl 1:i96-106. PMID: 19386638; PMCID: PMC2693539.
    112. Hoch RV, Rubenstein J, Pleasure S. Genes and signaling events that establish regional patterning of the mammalian forebrain. Semin Cell Dev Biol. 2009 Jun; 20(4):378-86. PMID: 19560042.
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    113. Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein J. Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 01; 512(4):556-72. PMID: 19030180; PMCID: PMC2761428.
    114. Potter GB, Petryniak MA, Shevchenko E, McKinsey GL, Ekker M, Rubenstein J. Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons. Mol Cell Neurosci. 2009 Feb; 40(2):167-86. PMID: 19026749; PMCID: PMC2693920.
    115. Walsh CA, Morrow EM, Rubenstein J. Autism and brain development. Cell. 2008 Oct 31; 135(3):396-400. PMID: 18984148; PMCID: PMC2701104.
    116. Colasante G, Collombat P, Raimondi V, Bonanomi D, Ferrai C, Maira M, Yoshikawa K, Mansouri A, Valtorta F, Rubenstein J, Broccoli V. Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. J Neurosci. 2008 Oct 15; 28(42):10674-86. PMID: 18923043; PMCID: PMC3844830.
    117. Zhao Y, Flandin P, Long JE, Cuesta MD, Westphal H, Rubenstein J. Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol. 2008 Sep 01; 510(1):79-99. PMID: 18613121; PMCID: PMC2547494.
    118. Jeong J, Li X, McEvilly RJ, Rosenfeld MG, Lufkin T, Rubenstein J. Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development. 2008 Sep; 135(17):2905-16. PMID: 18697905; PMCID: PMC4913551.
    119. Ohtsuka N, Tansky MF, Kuang H, Kourrich S, Thomas MJ, Rubenstein J, Ekker M, Leeman SE, Tsien JZ. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12961-6. PMID: 18728179; PMCID: PMC2529108.
    120. Ghanem N, Yu M, Poitras L, Rubenstein J, Ekker M. Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer. Dev Biol. 2008 Oct 15; 322(2):415-24. PMID: 18706405.
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    121. Sunwoo JB, Kim S, Yang L, Naik T, Higuchi DA, Rubenstein J, Yokoyama WM. Distal-less homeobox transcription factors regulate development and maturation of natural killer cells. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10877-82. PMID: 18664585; PMCID: PMC2504821.
    122. Borello U, Cobos I, Long JE, McWhirter JR, Murre C, Rubenstein J. FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev. 2008 Jul 14; 3:17. PMID: 18625063; PMCID: PMC2492847.
    123. Cholfin JA, Rubenstein J. Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2. J Comp Neurol. 2008 Jul 10; 509(2):144-55. PMID: 18459137; PMCID: PMC4399554.
    124. Vasudevan A, Long JE, Crandall JE, Rubenstein J, Bhide PG. Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nat Neurosci. 2008 Apr; 11(4):429-39. PMID: 18344991; PMCID: PMC2754271.
    125. Li G, Adesnik H, Li J, Long J, Nicoll RA, Rubenstein J, Pleasure SJ. Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci. 2008 Jan 30; 28(5):1085-98. PMID: 18234887; PMCID: PMC3072297.
    126. García-López M, Abellán A, Legaz I, Rubenstein J, Puelles L, Medina L. Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008 Jan 01; 506(1):46-74. PMID: 17990271; PMCID: PMC4916653.
    127. Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein J. COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling. Cereb Cortex. 2008 Sep; 18(9):2117-31. PMID: 18165280; PMCID: PMC2733307.
    128. Bardet SM, Martinez-de-la-Torre M, Northcutt RG, Rubenstein J, Puelles L. Conserved pattern of OTP-positive cells in the paraventricular nucleus and other hypothalamic sites of tetrapods. Brain Res Bull. 2008 Mar 18; 75(2-4):231-5. PMID: 18331876.
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    129. Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein J, Mucke L. Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 2008 Apr; 7(3):344-54. PMID: 17908176.
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    130. Flames N, Pla R, Gelman DM, Rubenstein J, Puelles L, Marín O. Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci. 2007 Sep 05; 27(36):9682-95. PMID: 17804629; PMCID: PMC4916652.
    131. Petryniak MA, Potter GB, Rowitch DH, Rubenstein J. Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron. 2007 Aug 02; 55(3):417-33. PMID: 17678855; PMCID: PMC2039927.
    132. Kohwi M, Petryniak MA, Long JE, Ekker M, Obata K, Yanagawa Y, Rubenstein J, Alvarez-Buylla A. A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors. J Neurosci. 2007 Jun 27; 27(26):6878-91. PMID: 17596436; PMCID: PMC4917362.
    133. Cobos I, Borello U, Rubenstein J. Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron. 2007 Jun 21; 54(6):873-88. PMID: 17582329; PMCID: PMC4921237.
    134. Ghanem N, Yu M, Long J, Hatch G, Rubenstein J, Ekker M. Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons. J Neurosci. 2007 May 09; 27(19):5012-22. PMID: 17494687; PMCID: PMC4917363.
    135. Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, Rubenstein J, Broccoli V. Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci. 2007 Apr 25; 27(17):4786-98. PMID: 17460091; PMCID: PMC4916654.
    136. Cholfin JA, Rubenstein J. Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7652-7. PMID: 17442747; PMCID: PMC1863435.
    137. Long JE, Garel S, Alvarez-Dolado M, Yoshikawa K, Osumi N, Alvarez-Buylla A, Rubenstein J. Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci. 2007 Mar 21; 27(12):3230-43. PMID: 17376983; PMCID: PMC4922751.
    138. Cholfin JA, Rubenstein J. Genetic regulation of prefrontal cortex development and function. Novartis Found Symp. 2007; 288:165-73; discussion 173-7, 276-81. PMID: 18494258.
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    139. Edmonds L, Liu A, Kwan JJ, Avanessy A, Caracoglia M, Yang I, Maxwell KL, Rubenstein J, Davidson AR, Donaldson LW. The NMR structure of the gpU tail-terminator protein from bacteriophage lambda: identification of sites contributing to Mg(II)-mediated oligomerization and biological function. J Mol Biol. 2007 Jan 05; 365(1):175-86. PMID: 17056065.
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    140. Zhou CJ, Borello U, Rubenstein J, Pleasure SJ. Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience. 2006 Nov 03; 142(4):1119-31. PMID: 16920270.
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    141. Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R, Kelsch W, Jacob W, Marsch R, Ekker M, Long J, Rubenstein J, Goebbels S, Nave KA, During M, Klugmann M, Wölfel B, Dodt HU, Zieglgänsberger W, Wotjak CT, Mackie K, Elphick MR, Marsicano G, Lutz B. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006 Aug 17; 51(4):455-66. PMID: 16908411; PMCID: PMC1769341.
    142. Alvarez-Dolado M, Calcagnotto ME, Karkar KM, Southwell DG, Jones-Davis DM, Estrada RC, Rubenstein J, Alvarez-Buylla A, Baraban SC. Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci. 2006 Jul 12; 26(28):7380-9. PMID: 16837585; PMCID: PMC1550786.
    143. Cobos I, Long JE, Thwin MT, Rubenstein J. Cellular patterns of transcription factor expression in developing cortical interneurons. Cereb Cortex. 2006 Jul; 16 Suppl 1:i82-8. PMID: 16766712.
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    144. Moldin SO, Rubenstein J, Hyman SE. Can autism speak to neuroscience? J Neurosci. 2006 Jun 28; 26(26):6893-6. PMID: 16807319.
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    145. Storm EE, Garel S, Borello U, Hebert JM, Martinez S, McConnell SK, Martin GR, Rubenstein J. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development. 2006 May; 133(9):1831-44. PMID: 16613831.
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    146. Polley DB, Cobos I, Merzenich MM, Rubenstein J. Severe hearing loss in Dlxl mutant mice. Hear Res. 2006 Apr; 214(1-2):84-8. PMID: 16632068.
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    147. Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein J, Tessier-Lavigne M, Okano H, Alvarez-Buylla A. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science. 2006 Feb 03; 311(5761):629-32. PMID: 16410488.
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    148. Sur M, Rubenstein J. Patterning and plasticity of the cerebral cortex. Science. 2005 Nov 04; 310(5749):805-10. PMID: 16272112.
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    149. Hamilton SP, Woo JM, Carlson EJ, Ghanem N, Ekker M, Rubenstein J. Analysis of four DLX homeobox genes in autistic probands. BMC Genet. 2005 Nov 02; 6:52. PMID: 16266434; PMCID: PMC1310613.
    150. Depew MJ, Simpson CA, Morasso M, Rubenstein J. Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development. J Anat. 2005 Nov; 207(5):501-61. PMID: 16313391; PMCID: PMC1571560.
    151. Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andrè A, Cocchia M, Guardiola O, Ballabio A, Rubenstein J, Zollo M. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17; 25(33):7586-600. PMID: 16107646.
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    152. Kohwi M, Osumi N, Rubenstein J, Alvarez-Buylla A. Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. J Neurosci. 2005 Jul 27; 25(30):6997-7003. PMID: 16049175.
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    153. Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein J. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug; 8(8):1059-68. PMID: 16007083.
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    154. Cobos I, Broccoli V, Rubenstein J. The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain. J Comp Neurol. 2005 Mar 14; 483(3):292-303. PMID: 15682394.
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    155. Studer M, Filosa A, Rubenstein J. The nuclear receptor COUP-TFI represses differentiation of Cajal-Retzius cells. Brain Res Bull. 2005 Sep 15; 66(4-6):394-401. PMID: 16144621.
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    156. Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein J, Robert B, Mellon PL. Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005 May 13; 280(19):19156-65. PMID: 15743757; PMCID: PMC2932481.
    157. de Melo J, Du G, Fonseca M, Gillespie LA, Turk WJ, Rubenstein J, Eisenstat DD. Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina. Development. 2005 Jan; 132(2):311-22. PMID: 15604100.
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    158. Wang TF, Ding CN, Wang GS, Luo SC, Lin YL, Ruan Y, Hevner R, Rubenstein J, Hsueh YP. Identification of Tbr-1/CASK complex target genes in neurons. J Neurochem. 2004 Dec; 91(6):1483-92. PMID: 15584924.
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    159. Faedo A, Quinn JC, Stoney P, Long JE, Dye C, Zollo M, Rubenstein J, Price DJ, Bulfone A. Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon. Dev Dyn. 2004 Nov; 231(3):614-20. PMID: 15376329.
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    160. Flames N, Long JE, Garratt AN, Fischer TM, Gassmann M, Birchmeier C, Lai C, Rubenstein J, Marín O. Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron. 2004 Oct 14; 44(2):251-61. PMID: 15473965.
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    161. Huffman KJ, Garel S, Rubenstein J. Fgf8 regulates the development of intra-neocortical projections. J Neurosci. 2004 Oct 13; 24(41):8917-23. PMID: 15483110.
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    162. Yun K, Mantani A, Garel S, Rubenstein J, Israel MA. Id4 regulates neural progenitor proliferation and differentiation in vivo. Development. 2004 Nov; 131(21):5441-8. PMID: 15469968.
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    163. Jones EG, Rubenstein J. Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey. J Comp Neurol. 2004 Sep 06; 477(1):55-80. PMID: 15281080.
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    164. Garel S, Rubenstein J. Intermediate targets in formation of topographic projections: inputs from the thalamocortical system. Trends Neurosci. 2004 Sep; 27(9):533-9. PMID: 15331235.
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    165. Zarbalis K, May SR, Shen Y, Ekker M, Rubenstein J, Peterson AS. A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug; 2(8):E219. PMID: 15314648; PMCID: PMC509294.
    166. Medina L, Legaz I, González G, De Castro F, Rubenstein J, Puelles L. Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex. J Comp Neurol. 2004 Jul 05; 474(4):504-23. PMID: 15174069.
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    167. Pan Q, Li C, Xiao J, Kimura S, Rubenstein J, Puelles L, Minoo P. In vivo characterization of the Nkx2.1 promoter/enhancer elements in transgenic mice. Gene. 2004 Apr 28; 331:73-82. PMID: 15094193.
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    168. Xu Q, Cobos I, De La Cruz E, Rubenstein J, Anderson SA. Origins of cortical interneuron subtypes. J Neurosci. 2004 Mar 17; 24(11):2612-22. PMID: 15028753.
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    169. Liu R, Cai J, Hu X, Tan M, Qi Y, German M, Rubenstein J, Sander M, Qiu M. Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor. Development. 2003 Dec; 130(25):6221-31. PMID: 14602683.
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    170. Rubenstein J, Merzenich MM. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav. 2003 Oct; 2(5):255-67. PMID: 14606691.
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    171. Blackshear PJ, Graves JP, Stumpo DJ, Cobos I, Rubenstein J, Zeldin DC. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development. 2003 Oct; 130(19):4539-52. PMID: 12925582.
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    172. Puelles L, Rubenstein J. Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci. 2003 Sep; 26(9):469-76. PMID: 12948657.
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    173. Zhao Y, Marín O, Hermesz E, Powell A, Flames N, Palkovits M, Rubenstein J, Westphal H. The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):9005-10. PMID: 12855770; PMCID: PMC166428.
    174. Yun K, Garel S, Fischman S, Rubenstein J. Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia. J Comp Neurol. 2003 Jun 23; 461(2):151-65. PMID: 12724834.
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    175. Marín O, Plump AS, Flames N, Sánchez-Camacho C, Tessier-Lavigne M, Rubenstein J. Directional guidance of interneuron migration to the cerebral cortex relies on subcortical Slit1/2-independent repulsion and cortical attraction. Development. 2003 May; 130(9):1889-901. PMID: 12642493.
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    176. Andrews GL, Yun K, Rubenstein J, Mastick GS. Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus. Mol Cell Neurosci. 2003 May; 23(1):107-20. PMID: 12799141.
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    177. Garel S, Huffman KJ, Rubenstein J. Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development. 2003 May; 130(9):1903-14. PMID: 12642494.
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    178. Ghanem N, Jarinova O, Amores A, Long Q, Hatch G, Park BK, Rubenstein J, Ekker M. Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters. Genome Res. 2003 Apr; 13(4):533-43. PMID: 12670995; PMCID: PMC430168.
    179. Bishop KM, Garel S, Nakagawa Y, Rubenstein J, O'Leary DD. Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding. J Comp Neurol. 2003 Mar 17; 457(4):345-60. PMID: 12561075.
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    180. Hevner RF, Daza RA, Rubenstein J, Stunnenberg H, Olavarria JF, Englund C. Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons. Dev Neurosci. 2003 Mar-Aug; 25(2-4):139-51. PMID: 12966212.
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    181. Marín O, Rubenstein J. Cell migration in the forebrain. Annu Rev Neurosci. 2003; 26:441-83. PMID: 12626695.
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    182. Storm EE, Rubenstein J, Martin GR. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1757-62. PMID: 12574514; PMCID: PMC149906.
    183. Long JE, Garel S, Depew MJ, Tobet S, Rubenstein J. DLX5 regulates development of peripheral and central components of the olfactory system. J Neurosci. 2003 Jan 15; 23(2):568-78. PMID: 12533617.
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    184. Garel S, Yun K, Grosschedl R, Rubenstein J. The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice. Development. 2002 Dec; 129(24):5621-34. PMID: 12421703.
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    185. Yun K, Fischman S, Johnson J, Hrabe de Angelis M, Weinmaster G, Rubenstein J. Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development. 2002 Nov; 129(21):5029-40. PMID: 12397111.
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    186. Panganiban G, Rubenstein J. Developmental functions of the Distal-less/Dlx homeobox genes. Development. 2002 Oct; 129(19):4371-86. PMID: 12223397.
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    187. Bishop KM, Rubenstein J, O'Leary DD. Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci. 2002 Sep 01; 22(17):7627-38. PMID: 12196586.
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    188. Depew MJ, Lufkin T, Rubenstein J. Specification of jaw subdivisions by Dlx genes. Science. 2002 Oct 11; 298(5592):381-5. PMID: 12193642.
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    189. Gorski JA, Talley T, Qiu M, Puelles L, Rubenstein J, Jones KR. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci. 2002 Aug 01; 22(15):6309-14. PMID: 12151506.
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    190. Faedo A, Ficara F, Ghiani M, Aiuti A, Rubenstein J, Bulfone A. Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Mech Dev. 2002 Aug; 116(1-2):157-60. PMID: 12128215.
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    191. Anderson SA, Kaznowski CE, Horn C, Rubenstein J, McConnell SK. Distinct origins of neocortical projection neurons and interneurons in vivo. Cereb Cortex. 2002 Jul; 12(7):702-9. PMID: 12050082.
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    192. Hevner RF, Miyashita-Lin E, Rubenstein J. Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J Comp Neurol. 2002 May 20; 447(1):8-17. PMID: 11967891.
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    193. Marín O, Baker J, Puelles L, Rubenstein J. Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Development. 2002 Feb; 129(3):761-73. PMID: 11830575.
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    194. Bagri A, Marín O, Plump AS, Mak J, Pleasure SJ, Rubenstein J, Tessier-Lavigne M. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 2002 Jan 17; 33(2):233-48. PMID: 11804571.
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    195. Stühmer T, Anderson SA, Ekker M, Rubenstein J. Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression. Development. 2002 Jan; 129(1):245-52. PMID: 11782417.
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    196. Ohkubo Y, Chiang C, Rubenstein J. Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles. Neuroscience. 2002; 111(1):1-17. PMID: 11955708.
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    197. Stühmer T, Puelles L, Ekker M, Rubenstein J. Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cereb Cortex. 2002 Jan; 12(1):75-85. PMID: 11734534.
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    198. Garda AL, Puelles L, Rubenstein J, Medina L. Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis. Neuroscience. 2002; 113(3):689-98. PMID: 12150789.
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    199. Cobos I, Shimamura K, Rubenstein J, Martínez S, Puelles L. Fate map of the avian anterior forebrain at the four-somite stage, based on the analysis of quail-chick chimeras. Dev Biol. 2001 Nov 01; 239(1):46-67. PMID: 11784018.
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    200. Marín O, Rubenstein J. A long, remarkable journey: tangential migration in the telencephalon. Nat Rev Neurosci. 2001 Nov; 2(11):780-90. PMID: 11715055.
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    201. Yu G, Zerucha T, Ekker M, Rubenstein J. Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins. Brain Res Dev Brain Res. 2001 Oct 24; 130(2):217-30. PMID: 11675124.
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    202. Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein J, O'Gorman S, Cleary ML. Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development. 2001 Sep; 128(18):3543-57. PMID: 11566859.
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    203. Pham TA, Rubenstein J, Silva AJ, Storm DR, Stryker MP. The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons. Neuron. 2001 Aug 16; 31(3):409-20. PMID: 11516398.
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    204. Marín O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein J. Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions. Science. 2001 Aug 03; 293(5531):872-5. PMID: 11486090.
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    205. Schneider RA, Hu D, Rubenstein J, Maden M, Helms JA. Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development. 2001 Jul; 128(14):2755-67. PMID: 11526081.
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    206. Qi Y, Cai J, Wu Y, Wu R, Lee J, Fu H, Rao M, Sussel L, Rubenstein J, Qiu M. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development. 2001 Jul; 128(14):2723-33. PMID: 11526078.
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    207. Xu SC, Harris MA, Rubenstein J, Mundy GR, Harris SE. Bone morphogenetic protein-2 (BMP-2) signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2. DNA Cell Biol. 2001 Jun; 20(6):359-65. PMID: 11445007.
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    208. Puelles E, Rubenstein J, Puelles L. Chicken Nkx6.1 expression at advanced stages of development identifies distinct brain nuclei derived from the basal plate. Mech Dev. 2001 Apr; 102(1-2):279-82. PMID: 11287211.
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    209. Kim AS, Anderson SA, Rubenstein J, Lowenstein DH, Pleasure SJ. Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. J Neurosci. 2001 Mar 01; 21(5):RC132. PMID: 11222670.
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    210. Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein J. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001 Feb; 29(2):353-66. PMID: 11239428.
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    211. Anderson SA, Marín O, Horn C, Jennings K, Rubenstein J. Distinct cortical migrations from the medial and lateral ganglionic eminences. Development. 2001 Feb; 128(3):353-63. PMID: 11152634.
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    212. Yun K, Potter S, Rubenstein J. Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2001 Jan; 128(2):193-205. PMID: 11124115.
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    213. Crossley PH, Martinez S, Ohkubo Y, Rubenstein J. Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles. Neuroscience. 2001; 108(2):183-206. PMID: 11734354.
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    214. Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH, Rubenstein J. Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons. Neuron. 2000 Dec; 28(3):727-40. PMID: 11163262.
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    215. Wilson SW, Rubenstein J. Induction and dorsoventral patterning of the telencephalon. Neuron. 2000 Dec; 28(3):641-51. PMID: 11163256.
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    216. Sander M, Paydar S, Ericson J, Briscoe J, Berber E, German M, Jessell TM, Rubenstein J. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates. Genes Dev. 2000 Sep 01; 14(17):2134-9. PMID: 10970877; PMCID: PMC316892.
    217. Puelles L, Kuwana E, Puelles E, Bulfone A, Shimamura K, Keleher J, Smiga S, Rubenstein J. Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1. J Comp Neurol. 2000 Aug 28; 424(3):409-38. PMID: 10906711.
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    218. Marin O, Anderson SA, Rubenstein J. Origin and molecular specification of striatal interneurons. J Neurosci. 2000 Aug 15; 20(16):6063-76. PMID: 10934256.
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    219. Galceran J, Miyashita-Lin EM, Devaney E, Rubenstein J, Grosschedl R. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 2000 Feb; 127(3):469-82. PMID: 10631168.
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    220. Zerucha T, Stühmer T, Hatch G, Park BK, Long Q, Yu G, Gambarotta A, Schultz JR, Rubenstein J, Ekker M. A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain. J Neurosci. 2000 Jan 15; 20(2):709-21. PMID: 10632600.
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    221. Rubenstein J. Intrinsic and extrinsic control of cortical development. Novartis Found Symp. 2000; 228:67-75; discussion 75-82, 109-13. PMID: 10929317.
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    222. Parnavelas JG, Anderson SA, Lavdas AA, Grigoriou M, Pachnis V, Rubenstein J. The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex. Novartis Found Symp. 2000; 228:129-39; discussion 139-47. PMID: 10929320.
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    223. Thomas BL, Liu JK, Rubenstein J, Sharpe PT. Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch. Development. 2000 Jan; 127(2):217-24. PMID: 10603340.
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    224. Trumpp A, Depew MJ, Rubenstein J, Bishop JM, Martin GR. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 1999 Dec 01; 13(23):3136-48. PMID: 10601039; PMCID: PMC317178.
    225. Eisenstat DD, Liu JK, Mione M, Zhong W, Yu G, Anderson SA, Ghattas I, Puelles L, Rubenstein J. DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation. J Comp Neurol. 1999 Nov 15; 414(2):217-37. PMID: 10516593.
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    226. Depew MJ, Liu JK, Long JE, Presley R, Meneses JJ, Pedersen RA, Rubenstein J. Dlx5 regulates regional development of the branchial arches and sensory capsules. Development. 1999 Sep; 126(17):3831-46. PMID: 10433912.
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    227. Anderson S, Mione M, Yun K, Rubenstein J. Differential origins of neocortical projection and local circuit neurons: role of Dlx genes in neocortical interneuronogenesis. Cereb Cortex. 1999 Sep; 9(6):646-54. PMID: 10498283.
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    228. Rubenstein J, Rakic P. Genetic control of cortical development. Cereb Cortex. 1999 Sep; 9(6):521-3. PMID: 10498269.
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    229. Rubenstein J, Anderson S, Shi L, Miyashita-Lin E, Bulfone A, Hevner R. Genetic control of cortical regionalization and connectivity. Cereb Cortex. 1999 Sep; 9(6):524-32. PMID: 10498270.
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    230. Miyashita-Lin EM, Hevner R, Wassarman KM, Martinez S, Rubenstein J. Early neocortical regionalization in the absence of thalamic innervation. Science. 1999 Aug 06; 285(5429):906-9. PMID: 10436162.
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    231. Sussel L, Marin O, Kimura S, Rubenstein J. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999 Aug; 126(15):3359-70. PMID: 10393115.
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    232. Bulfone A, Martinez S, Marigo V, Campanella M, Basile A, Quaderi N, Gattuso C, Rubenstein J, Ballabio A. Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development. Mech Dev. 1999 Jun; 84(1-2):133-8. PMID: 10473127.
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    233. Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein J, Ericson J. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15; 398(6728):622-7. PMID: 10217145.
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    234. Puelles L, Kuwana E, Puelles E, Rubenstein J. Comparison of the mammalian and avian telencephalon from the perspective of gene expression data. Eur J Morphol. 1999 Apr; 37(2-3):139-50. PMID: 10342446.
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    235. Timpe LC, Jin KL, Puelles L, Rubenstein J. Cyclic nucleotide-gated cation channel expression in embryonic chick brain. Brain Res Mol Brain Res. 1999 Mar 20; 66(1-2):175-8. PMID: 10095089.
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    236. Golden JA, Bracilovic A, McFadden KA, Beesley JS, Rubenstein J, Grinspan JB. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2439-44. PMID: 10051661; PMCID: PMC26803.
    237. Martinez S, Crossley PH, Cobos I, Rubenstein J, Martin GR. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development. 1999 Mar; 126(6):1189-200. PMID: 10021338.
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    238. Begbie J, Brunet JF, Rubenstein J, Graham A. Induction of the epibranchial placodes. Development. 1999 Feb; 126(5):895-902. PMID: 9927591.
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    239. Marcus RC, Shimamura K, Sretavan D, Lai E, Rubenstein J, Mason CA. Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells. J Comp Neurol. 1999 Jan 18; 403(3):346-58. PMID: 9886035.
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    240. Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S, Meneses J, Pedersen R, Axel R, Rubenstein J. An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron. 1998 Dec; 21(6):1273-82. PMID: 9883721.
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    241. Lidral AC, Romitti PA, Basart AM, Doetschman T, Leysens NJ, Daack-Hirsch S, Semina EV, Johnson LR, Machida J, Burds A, Parnell TJ, Rubenstein J, Murray JC. Association of MSX1 and TGFB3 with nonsyndromic clefting in humans. Am J Hum Genet. 1998 Aug; 63(2):557-68. PMID: 9683588; PMCID: PMC1377298.
    242. Rubenstein J. Development of serotonergic neurons and their projections. Biol Psychiatry. 1998 Aug 01; 44(3):145-50. PMID: 9693386.
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    243. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein J, German MS. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun; 125(12):2213-21. PMID: 9584121.
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    244. Ye W, Shimamura K, Rubenstein J, Hynes MA, Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell. 1998 May 29; 93(5):755-66. PMID: 9630220.
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    245. Rubenstein J. Development of the cerebral cortex: V. Transcription factors and brain development. J Am Acad Child Adolesc Psychiatry. 1998 May; 37(5):561-2. PMID: 9585660.
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    247. Rubenstein J, Beachy PA. Patterning of the embryonic forebrain. Curr Opin Neurobiol. 1998 Feb; 8(1):18-26. PMID: 9568388.
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    248. Thomas BL, Tucker AS, Ferguson C, Qiu M, Rubenstein J, Sharpe PT. Molecular control of odontogenic patterning: positional dependent initiation and morphogenesis. Eur J Oral Sci. 1998 Jan; 106 Suppl 1:44-7. PMID: 9541202.
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    249. Rubenstein J, Shimamura K, Martinez S, Puelles L. Regionalization of the prosencephalic neural plate. Annu Rev Neurosci. 1998; 21:445-77. PMID: 9530503.
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    250. Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein J, Sharpe PT. Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development. 1997 Dec; 124(23):4811-8. PMID: 9428417.
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    251. Liu JK, Ghattas I, Liu S, Chen S, Rubenstein J. Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev Dyn. 1997 Dec; 210(4):498-512. PMID: 9415433.
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    252. Anderson SA, Eisenstat DD, Shi L, Rubenstein J. Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes. Science. 1997 Oct 17; 278(5337):474-6. PMID: 9334308.
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    253. Wassarman KM, Lewandoski M, Campbell K, Joyner AL, Rubenstein J, Martinez S, Martin GR. Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug; 124(15):2923-34. PMID: 9247335.
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    254. Shimamura K, Rubenstein J. Inductive interactions direct early regionalization of the mouse forebrain. Development. 1997 Jul; 124(14):2709-18. PMID: 9226442.
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    255. Anderson SA, Qiu M, Bulfone A, Eisenstat DD, Meneses J, Pedersen R, Rubenstein J. Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron. 1997 Jul; 19(1):27-37. PMID: 9247261.
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    256. Qiu M, Bulfone A, Ghattas I, Meneses JJ, Christensen L, Sharpe PT, Presley R, Pedersen RA, Rubenstein J. Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997 May 15; 185(2):165-84. PMID: 9187081.
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    257. Hernandez MC, Andres-Barquin PJ, Martinez S, Bulfone A, Rubenstein J, Israel MA. ENC-1: a novel mammalian kelch-related gene specifically expressed in the nervous system encodes an actin-binding protein. J Neurosci. 1997 May 01; 17(9):3038-51. PMID: 9096139.
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    258. Ding M, Robel L, James AJ, Eisenstat DD, Leckman JF, Rubenstein J, Vaccarino FM. Dlx-2 homeobox gene controls neuronal differentiation in primary cultures of developing basal ganglia. J Mol Neurosci. 1997 Apr; 8(2):93-113. PMID: 9188040.
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    259. Barondes SH, Alberts BM, Andreasen NC, Bargmann C, Benes F, Goldman-Rakic P, Gottesman I, Heinemann SF, Jones EG, Kirschner M, Lewis D, Raff M, Roses A, Rubenstein J, Snyder S, Watson SJ, Weinberger DR, Yolken RH. Workshop on schizophrenia. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1612-4. PMID: 9050825; PMCID: PMC34140.
    260. Shimamura K, Martinez S, Puelles L, Rubenstein J. Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains. Dev Neurosci. 1997; 19(1):88-96. PMID: 9078438.
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    262. McGuinness T, Porteus MH, Smiga S, Bulfone A, Kingsley C, Qiu M, Liu JK, Long JE, Xu D, Rubenstein J. Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus. Genomics. 1996 Aug 01; 35(3):473-85. PMID: 8812481.
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    263. Hartigan DJ, Rubenstein J. The cDNA sequence of murine Nkx-2.2. Gene. 1996 Feb 12; 168(2):271-2. PMID: 8654958.
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    264. Fan CM, Kuwana E, Bulfone A, Fletcher CF, Copeland NG, Jenkins NA, Crews S, Martinez S, Puelles L, Rubenstein J, Tessier-Lavigne M. Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Mol Cell Neurosci. 1996 Jan; 7(1):1-16. PMID: 8812055.
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    265. Shimamura K, Hartigan DJ, Martinez S, Puelles L, Rubenstein J. Longitudinal organization of the anterior neural plate and neural tube. Development. 1995 Dec; 121(12):3923-33. PMID: 8575293.
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    266. Compagnone NA, Bulfone A, Rubenstein J, Mellon SH. Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology. 1995 Nov; 136(11):5212-23. PMID: 7588260.
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    267. Qiu M, Bulfone A, Martinez S, Meneses JJ, Shimamura K, Pedersen RA, Rubenstein J. Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain. Genes Dev. 1995 Oct 15; 9(20):2523-38. PMID: 7590232.
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    268. Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein J. T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron. 1995 Jul; 15(1):63-78. PMID: 7619531.
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    269. Zhu W, Dahmen J, Bulfone A, Rigolet M, Hernandez MC, Kuo WL, Puelles L, Rubenstein J, Israel MA. Id gene expression during development and molecular cloning of the human Id-1 gene. Brain Res Mol Brain Res. 1995 Jun; 30(2):312-26. PMID: 7637581.
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    270. Compagnone NA, Bulfone A, Rubenstein J, Mellon SH. Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis. Endocrinology. 1995 Jun; 136(6):2689-96. PMID: 7750493.
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    271. Thomas BL, Porteus MH, Rubenstein J, Sharpe PT. The spatial localization of Dlx-2 during tooth development. Connect Tissue Res. 1995; 32(1-4):27-34. PMID: 7554927.
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    272. Porteus MH, Bulfone A, Liu JK, Puelles L, Lo LC, Rubenstein J. DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain. J Neurosci. 1994 Nov; 14(11 Pt 1):6370-83. PMID: 7965042.
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    273. Rubenstein J, Martinez S, Shimamura K, Puelles L. The embryonic vertebrate forebrain: the prosomeric model. Science. 1994 Oct 28; 266(5185):578-80. PMID: 7939711.
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    274. Rubenstein J, Puelles L. Homeobox gene expression during development of the vertebrate brain. Curr Top Dev Biol. 1994; 29:1-63. PMID: 7828435.
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    275. Puelles L, Rubenstein J. Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization. Trends Neurosci. 1993 Nov; 16(11):472-9. PMID: 7507621.
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    276. Bulfone A, Puelles L, Porteus MH, Frohman MA, Martin GR, Rubenstein J. Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci. 1993 Jul; 13(7):3155-72. PMID: 7687285.
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    277. Bulfone A, Kim HJ, Puelles L, Porteus MH, Grippo JF, Rubenstein J. The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos. Mech Dev. 1993 Mar; 40(3):129-40. PMID: 8098616.
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    278. Ozçelik T, Porteus MH, Rubenstein J, Francke U. DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. Genomics. 1992 Aug; 13(4):1157-61. PMID: 1354641.
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    279. Porteus MH, Bulfone A, Ciaranello RD, Rubenstein J. A partial cDNA sequence of the Dlx-2 cDNA. Neuron. 1992 Jul; 9(1):187. PMID: 1632970.
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    280. Porteus MH, Brice AE, Bulfone A, Usdin TB, Ciaranello RD, Rubenstein J. Isolation and characterization of a library of cDNA clones that are preferentially expressed in the embryonic telencephalon. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):7-22. PMID: 1372074.
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    281. Porteus MH, Bulfone A, Ciaranello RD, Rubenstein J. Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain. Neuron. 1991 Aug; 7(2):221-9. PMID: 1678612.
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    282. Sanes JR, Rubenstein J, Nicolas JF. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 1986 Dec 01; 5(12):3133-42. PMID: 3102226; PMCID: PMC1167303.
    283. Nicolas JF, Rubenstein J, Bonnerot C, Jacob F. Introduction of genes into embryonal carcinoma cells and preimplantation embryos by retroviral vectors. Cold Spring Harb Symp Quant Biol. 1985; 50:713-20. PMID: 3868505.
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    284. Rubenstein J, Nicolas JF, Jacob F. [Nonsense RNA: a tool for specifically inhibiting the expression of a gene in vivo]. C R Acad Sci III. 1984; 299(8):271-4. PMID: 6210135.
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    285. Rubenstein J, Chappell TG. Construction of a synthetic messenger RNA encoding a membrane protein. J Cell Biol. 1983 May; 96(5):1464-9. PMID: 6341380; PMCID: PMC2112647.
    286. Rubenstein J, Fine RE, Luskey BD, Rothman JE. Purification of coated vesicles by agarose gel electrophoresis. J Cell Biol. 1981 May; 89(2):357-61. PMID: 6265464; PMCID: PMC2111692.
    287. Smith LM, Rubenstein J, Parce JW, McConnell HM. Lateral diffusion of M-13 coat protein in mixtures of phosphatidylcholine and cholesterol. Biochemistry. 1980 Dec 09; 19(25):5907-11. PMID: 7459346.
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    288. Rubenstein J, Owicki JC, McConnell HM. Dynamic properties of binary mixtures of phosphatidylcholines and cholesterol. Biochemistry. 1980 Feb 05; 19(3):569-73. PMID: 6243951.
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    289. Rubenstein J, Smith BA, McConnell HM. Lateral diffusion in binary mixtures of cholesterol and phosphatidylcholines. Proc Natl Acad Sci U S A. 1979 Jan; 76(1):15-8. PMID: 284326; PMCID: PMC382866.
    290. Rubenstein J, Brutlag D, Clayton DA. The mitochondrial DNA of Drosophila melanogaster exists in two distinct and stable superhelical forms. Cell. 1977 Oct; 12(2):471-82. PMID: 410503.
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    291. Hruska JF, Clayton DA, Rubenstein J, Robinson WS. Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction. J Virol. 1977 Feb; 21(2):666-72. PMID: 833942; PMCID: PMC353869.
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