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David Toczyski, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentHDF Comprehensive Cancer Ctr
Address1450 Third St
San Francisco CA 94158
Phone415-502-1301
EmailDavid.Toczyski@ucsf.edu
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation by post-translation modifications in response to stress
    NIH/NIGMS R35GM118104May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Identifying the targets of oncogenic/tumor-suppressive F box proteins
    NIH/NCI R21CA187685Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Yeast Chromosome Structure, Replication and Segregation
    NIH/NICHD R13HD053182Mar 1, 2006 - Feb 28, 2011
    Role: Principal Investigator
    Cell cycle regulation by ubiquitin ligases
    NIH/NIGMS R01GM070539Jun 1, 2004 - Apr 30, 2016
    Role: Principal Investigator
    Regulation and Targets of the DNA Damage Checkpoint
    NIH/NIGMS R01GM059691Aug 1, 1999 - Aug 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. van Emden TS, Forn M, Forné I, Sarkadi Z, Capella M, Martín Caballero L, Fischer-Burkart S, Brönner C, Simonetta M, Toczyski D, Halic M, Imhof A, Braun S. Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. EMBO Rep. 2018 Nov 12. PMID: 30420521.
      View in: PubMed
    2. Lao JP, Ulrich KM, Johnson JR, Newton BW, Vashisht AA, Wohlschlegel JA, Krogan NJ, Toczyski DP. The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1. G3 (Bethesda). 2018 Oct 30. PMID: 30377154.
      View in: PubMed
    3. Romero AM, Martínez-Pastor M, Du G, Solé C, Carlos M, Vergara SV, Sanvisens N, Wohlschlegel JA, Toczyski DP, Posas F, de Nadal E, Martínez-Pastor MT, Thiele DJ, Puig S. Phosphorylation and Proteasome Recognition of the mRNA-Binding Protein Cth2 Facilitates Yeast Adaptation to Iron Deficiency. MBio. 2018 Sep 18; 9(5). PMID: 30228242.
      View in: PubMed
    4. Mark KG, Loveless TB, Toczyski DP. Isolation of ubiquitinated substrates by tandem affinity purification of E3 ligase-polyubiquitin-binding domain fusions (ligase traps). Nat Protoc. 2016 Feb; 11(2):291-301. PMID: 26766115.
      View in: PubMed
    5. Meza-Gutierrez F, Hundley FV, Toczyski DP. Parallel Parkin: Cdc20 Takes a New Partner. Mol Cell. 2015 Oct 01; 60(1):3-4. PMID: 26431023.
      View in: PubMed
    6. Mark KG, Meza-Gutierrez F, Johnson JR, Newton BW, Krogan NJ, Toczyski DP. Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1. Biochemistry. 2015 Jul 28; 54(29):4423-6. PMID: 26161950; PMCID: PMC4816488.
    7. Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP. DNA Damage Regulates Translation through ß-TRCP Targeting of CReP. PLoS Genet. 2015 Jun; 11(6):e1005292. PMID: 26091241; PMCID: PMC4474599.
    8. Edenberg ER, Mark KG, Toczyski DP. Ndd1 turnover by SCF(Grr1) is inhibited by the DNA damage checkpoint in Saccharomyces cerevisiae. PLoS Genet. 2015 Apr; 11(4):e1005162. PMID: 25894965; PMCID: PMC4403921.
    9. Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski DP. Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Mol Cell Proteomics. 2015 Jan; 14(1):162-76. PMID: 25381059; PMCID: PMC4288252.
    10. Edenberg ER, Downey M, Toczyski D. Polymerase stalling during replication, transcription and translation. Curr Biol. 2014 May 19; 24(10):R445-52. PMID: 24845677.
      View in: PubMed
    11. Edenberg ER, Vashisht AA, Topacio BR, Wohlschlegel JA, Toczyski DP. Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5962-7. PMID: 24715726; PMCID: PMC4000829.
    12. Mark KG, Simonetta M, Maiolica A, Seller CA, Toczyski DP. Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins. Mol Cell. 2014 Jan 09; 53(1):148-61. PMID: 24389104; PMCID: PMC4032118.
    13. Edenberg ER, Vashisht A, Benanti JA, Wohlschlegel J, Toczyski DP. Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Mol Cell Biol. 2014 Feb; 34(4):725-38. PMID: 24324011; PMCID: PMC3911491.
    14. Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski DP. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol. 2013 Sep 09; 23(17):1638-48. PMID: 23973296; PMCID: PMC3982851.
    15. Landry BD, Doyle JP, Toczyski DP, Benanti JA. F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet. 2012; 8(7):e1002851. PMID: 22844257; PMCID: PMC3405998.
    16. Foe IT, Toczyski DP. Ubiquitin ligases: Taming the APC. Nat Chem Biol. 2012 Mar 16; 8(4):323-4. PMID: 22426190.
      View in: PubMed
    17. Berens TJ, Toczyski DP. Keeping it together in times of stress: checkpoint function at stalled replication forks. Mol Cell. 2012 Mar 09; 45(5):585-6. PMID: 22405272; PMCID: PMC3694131.
    18. Berens TJ, Toczyski DP. Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell. 2012 Mar; 23(6):1058-67. PMID: 22298423; PMCID: PMC3302733.
    19. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7. PMID: 22079111; PMCID: PMC3430386.
    20. Foe I, Toczyski D. Structural biology: a new look for the APC. Nature. 2011 Feb 10; 470(7333):182-3. PMID: 21307929.
      View in: PubMed
    21. Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21; 6:451. PMID: 21179023; PMCID: PMC3018166.
    22. Lopez-Mosqueda J, Vidanes GM, Toczyski DP. Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle. 2010 Nov 01; 9(21):4266-8. PMID: 20962588; PMCID: PMC3055179.
    23. Lopez-Mosqueda J, Maas NL, Jonsson ZO, Defazio-Eli LG, Wohlschlegel J, Toczyski DP. Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature. 2010 Sep 23; 467(7314):479-83. PMID: 20865002; PMCID: PMC3393088.
    24. Downey M, Edenberg ER, Toczyski DP. Repair scaffolding reaches new heights at blocked replication forks. Mol Cell. 2010 Jul 30; 39(2):162-4. PMID: 20670884.
      View in: PubMed
    25. Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP. CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. PLoS Biol. 2010 Jan 26; 8(1):e1000286. PMID: 20126259; PMCID: PMC2811153.
    26. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90. PMID: 19285942; PMCID: PMC2883288.
    27. Benanti JA, Toczyski DP. Cdc20, an activator at last. Mol Cell. 2008 Nov 21; 32(4):460-1. PMID: 19026776; PMCID: PMC2880502.
    28. Bonilla CY, Melo JA, Toczyski DP. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell. 2008 May 09; 30(3):267-76. PMID: 18471973; PMCID: PMC2879338.
    29. Benanti JA, Cheung SK, Brady MC, Toczyski DP. A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch. Nat Cell Biol. 2007 Oct; 9(10):1184-91. PMID: 17828247.
      View in: PubMed
    30. Vega LR, Phillips JA, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski DP, Zakian VA. Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. PLoS Genet. 2007 Jun; 3(6):e105. PMID: 17590086; PMCID: PMC1892048.
    31. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10. PMID: 17314980.
      View in: PubMed
    32. Miller KM, Maas NL, Toczyski DP. Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Cell Cycle. 2006 Nov; 5(22):2561-5. PMID: 17106263.
      View in: PubMed
    33. Thornton BR, Toczyski DP. Precise destruction: an emerging picture of the APC. Genes Dev. 2006 Nov 15; 20(22):3069-78. PMID: 17114580.
      View in: PubMed
    34. Maas NL, Miller KM, DeFazio LG, Toczyski DP. Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell. 2006 Jul 07; 23(1):109-19. PMID: 16818235.
      View in: PubMed
    35. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60. PMID: 16481473; PMCID: PMC1369047.
    36. Toczyski DP. Methods for studying adaptation to the DNA damage checkpoint in yeast. Methods Enzymol. 2006; 409:150-65. PMID: 16793400.
      View in: PubMed
    37. Vidanes GM, Bonilla CY, Toczyski DP. Complicated tails: histone modifications and the DNA damage response. Cell. 2005 Jul 01; 121(7):973-6. PMID: 15989948.
      View in: PubMed
    38. Garber PM, Vidanes GM, Toczyski DP. Damage in transition. Trends Biochem Sci. 2005 Feb; 30(2):63-6. PMID: 15691649.
      View in: PubMed
    39. Kaye JA, Melo JA, Cheung SK, Vaze MB, Haber JE, Toczyski DP. DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr Biol. 2004 Dec 14; 14(23):2096-106. PMID: 15589151.
      View in: PubMed
    40. Thornton BR, Chen KC, Cross FR, Tyson JJ, Toczyski DP. Cycling without the cyclosome: modeling a yeast strain lacking the APC. Cell Cycle. 2004 May; 3(5):629-33. PMID: 15034296.
      View in: PubMed
    41. Thornton BR, Toczyski DP. Securin and B-cyclin/CDK are the only essential targets of the APC. Nat Cell Biol. 2003 Dec; 5(12):1090-4. PMID: 14634663.
      View in: PubMed
    42. Melo J, Toczyski D. A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol. 2002 Apr; 14(2):237-45. PMID: 11891124.
      View in: PubMed