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The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2. bioRxiv. 2024 Mar 19.
Longhurst AD, Wang K, Suresh HG, Ketavarapu M, Ward HN, Jones IR, Narayan V, Hundley FV, Hassan AZ, Boone C, Myers CL, Shen Y, Ramani V, Andrews BJ, Toczyski DP. PMID: 38562687; PMCID: PMC10983909.
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Chemical-genetic CRISPR-Cas9 screens in human cells using a pathway-specific library. STAR Protoc. 2021 Sep 17; 2(3):100685.
Hundley FV, Toczyski DP. PMID: 34382013; PMCID: PMC8339234.
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2 Fields:
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HumansCells
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A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis. Mol Cell. 2021 03 18; 81(6):1319-1336.e9.
Hundley FV, Sanvisens Delgado N, Marin HC, Carr KL, Tian R, Toczyski DP. PMID: 33539788.
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16 Fields:
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HumansCells
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Fifty years of cycling. Mol Biol Cell. 2020 12 15; 31(26):2868-2870.
Biggins S, Hartwell L, Toczyski D. PMID: 33320706; PMCID: PMC7927189.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Redundant targeting of Isr1 by two CDKs in mitotic cells. Curr Genet. 2021 Feb; 67(1):79-83.
Alme EB, Toczyski DP. PMID: 33063175; PMCID: PMC7886961.
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AnimalsCells
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The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae. PLoS Genet. 2020 06; 16(6):e1008840.
Alme EB, Stevenson E, Krogan NJ, Swaney DL, Toczyski DP. PMID: 32579556; PMCID: PMC7340321.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Mck1 kinase is a new player in the DNA damage checkpoint pathway. PLoS Genet. 2019 10; 15(10):e1008372.
Sanvisens Delgado N, Toczyski DP. PMID: 31671089; PMCID: PMC6822710.
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PubMed Mentions:
2 Fields:
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A genetic approach to study polyubiquitination in Saccharomyces cerevisiae. Methods Enzymol. 2019; 618:49-72.
Meza-Gutierrez F, Simsek D, Toczyski DP. PMID: 30850062; PMCID: PMC6499080.
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AnimalsCells
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Genetic analysis reveals functions of atypical polyubiquitin chains. Elife. 2018 12 14; 7.
Meza Gutierrez F, Simsek D, Mizrak A, Deutschbauer A, Braberg H, Johnson J, Xu J, Shales M, Nguyen M, Tamse-Kuehn R, Palm C, Steinmetz LM, Krogan NJ, Toczyski DP. PMID: 30547882; PMCID: PMC6305200.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1. G3 (Bethesda). 2018 12 10; 8(12):3931-3944.
Lao JP, Ulrich KM, Johnson JR, Newton BW, Vashisht AA, Wohlschlegel JA, Krogan NJ, Toczyski DP. PMID: 30377154; PMCID: PMC6288840.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. EMBO Rep. 2019 01; 20(1).
van Emden TS, Forn M, Forné I, Sarkadi Z, Capella M, Martín Caballero L, Fischer-Burkart S, Brönner C, Simonetta M, Toczyski D, Halic M, Imhof A, Braun S. PMID: 30420521; PMCID: PMC6322387.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Phosphorylation and Proteasome Recognition of the mRNA-Binding Protein Cth2 Facilitates Yeast Adaptation to Iron Deficiency. mBio. 2018 09 18; 9(5).
Romero AM, Martínez-Pastor M, Du G, Solé C, Carlos M, Vergara SV, Sanvisens N, Wohlschlegel JA, Toczyski DP, Posas F, de Nadal E, Martínez-Pastor MT, Thiele DJ, Puig S. PMID: 30228242; PMCID: PMC6143738.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Isolation of ubiquitinated substrates by tandem affinity purification of E3 ligase-polyubiquitin-binding domain fusions (ligase traps). Nat Protoc. 2016 Feb; 11(2):291-301.
Mark KG, Loveless TB, Toczyski DP. PMID: 26766115; PMCID: PMC6499077.
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PubMed Mentions:
21 Fields:
Translation:
Cells
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Parallel Parkin: Cdc20 Takes a New Partner. Mol Cell. 2015 Oct 01; 60(1):3-4.
Meza-Gutierrez F, Hundley FV, Toczyski DP. PMID: 26431023; PMCID: PMC6604614.
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HumansAnimals
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Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1. Biochemistry. 2015 Jul 28; 54(29):4423-6.
Mark KG, Meza-Gutierrez F, Johnson JR, Newton BW, Krogan NJ, Toczyski DP. PMID: 26161950; PMCID: PMC4816488.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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DNA Damage Regulates Translation through β-TRCP Targeting of CReP. PLoS Genet. 2015 Jun; 11(6):e1005292.
Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP. PMID: 26091241; PMCID: PMC4474599.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Ndd1 turnover by SCF(Grr1) is inhibited by the DNA damage checkpoint in Saccharomyces cerevisiae. PLoS Genet. 2015 Apr; 11(4):e1005162.
Edenberg ER, Mark KG, Toczyski DP. PMID: 25894965; PMCID: PMC4403921.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Mol Cell Proteomics. 2015 Jan; 14(1):162-76.
Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski DP. PMID: 25381059; PMCID: PMC4288252.
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PubMed Mentions:
40 Fields:
Translation:
Cells
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Polymerase stalling during replication, transcription and translation. Curr Biol. 2014 May 19; 24(10):R445-52.
Edenberg ER, Downey M, Toczyski D. PMID: 24845677.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5962-7.
Edenberg ER, Vashisht AA, Topacio BR, Wohlschlegel JA, Toczyski DP. PMID: 24715726; PMCID: PMC4000829.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins. Mol Cell. 2014 Jan 09; 53(1):148-61.
Mark KG, Simonetta M, Maiolica A, Seller CA, Toczyski DP. PMID: 24389104; PMCID: PMC4032118.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Mol Cell Biol. 2014 Feb; 34(4):725-38.
Edenberg ER, Vashisht A, Benanti JA, Wohlschlegel J, Toczyski DP. PMID: 24324011; PMCID: PMC3911491.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol. 2013 Sep 09; 23(17):1638-48.
Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski DP. PMID: 23973296; PMCID: PMC3982851.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet. 2012; 8(7):e1002851.
Landry BD, Doyle JP, Toczyski DP, Benanti JA. PMID: 22844257; PMCID: PMC3405998.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Ubiquitin ligases: Taming the APC. Nat Chem Biol. 2012 Mar 16; 8(4):323-4.
Foe IT, Toczyski DP. PMID: 22426190.
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Animals
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Keeping it together in times of stress: checkpoint function at stalled replication forks. Mol Cell. 2012 Mar 09; 45(5):585-6.
Berens TJ, Toczyski DP. PMID: 22405272; PMCID: PMC3694131.
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8 Fields:
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Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell. 2012 Mar; 23(6):1058-67.
Berens TJ, Toczyski DP. PMID: 22298423; PMCID: PMC3302733.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7.
Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. PMID: 22079111; PMCID: PMC3430386.
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PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
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Structural biology: a new look for the APC. Nature. 2011 Feb 10; 470(7333):182-3.
Foe I, Toczyski D. PMID: 21307929.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21; 6:451.
Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. PMID: 21179023; PMCID: PMC3018166.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimals
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Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle. 2010 Nov 01; 9(21):4266-8.
Lopez-Mosqueda J, Vidanes GM, Toczyski DP. PMID: 20962588; PMCID: PMC3055179.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature. 2010 Sep 23; 467(7314):479-83.
Lopez-Mosqueda J, Maas NL, Jonsson ZO, Defazio-Eli LG, Wohlschlegel J, Toczyski DP. PMID: 20865002; PMCID: PMC3393088.
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PubMed Mentions:
117 Fields:
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AnimalsCells
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Repair scaffolding reaches new heights at blocked replication forks. Mol Cell. 2010 Jul 30; 39(2):162-4.
Downey M, Edenberg ER, Toczyski DP. PMID: 20670884; PMCID: PMC6499066.
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1 Fields:
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CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. PLoS Biol. 2010 Jan 26; 8(1):e1000286.
Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP. PMID: 20126259; PMCID: PMC2811153.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90.
Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. PMID: 19285942; PMCID: PMC2883288.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Cdc20, an activator at last. Mol Cell. 2008 Nov 21; 32(4):460-1.
Benanti JA, Toczyski DP. PMID: 19026776; PMCID: PMC2880502.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell. 2008 May 09; 30(3):267-76.
Bonilla CY, Melo JA, Toczyski DP. PMID: 18471973; PMCID: PMC2879338.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch. Nat Cell Biol. 2007 Oct; 9(10):1184-91.
Benanti JA, Cheung SK, Brady MC, Toczyski DP. PMID: 17828247.
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PubMed Mentions:
51 Fields:
Translation:
Cells
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Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. PLoS Genet. 2007 Jun; 3(6):e105.
Vega LR, Phillips JA, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski DP, Zakian VA. PMID: 17590086; PMCID: PMC1892048.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10.
Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ. PMID: 17314980.
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PubMed Mentions:
534 Fields:
Translation:
AnimalsCells
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Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Cell Cycle. 2006 Nov; 5(22):2561-5.
Miller KM, Maas NL, Toczyski DP. PMID: 17106263.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Precise destruction: an emerging picture of the APC. Genes Dev. 2006 Nov 15; 20(22):3069-78.
Thornton BR, Toczyski DP. PMID: 17114580.
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PubMed Mentions:
79 Fields:
Translation:
HumansCells
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Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell. 2006 Jul 07; 23(1):109-19.
Maas NL, Miller KM, DeFazio LG, Toczyski DP. PMID: 16818235.
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PubMed Mentions:
137 Fields:
Translation:
Cells
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An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60.
Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. PMID: 16481473; PMCID: PMC1369047.
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PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
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Methods for studying adaptation to the DNA damage checkpoint in yeast. Methods Enzymol. 2006; 409:150-65.
Toczyski DP. PMID: 16793400.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Complicated tails: histone modifications and the DNA damage response. Cell. 2005 Jul 01; 121(7):973-6.
Vidanes GM, Bonilla CY, Toczyski DP. PMID: 15989948.
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PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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Damage in transition. Trends Biochem Sci. 2005 Feb; 30(2):63-6.
Garber PM, Vidanes GM, Toczyski DP. PMID: 15691649.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr Biol. 2004 Dec 14; 14(23):2096-106.
Kaye JA, Melo JA, Cheung SK, Vaze MB, Haber JE, Toczyski DP. PMID: 15589151.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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Cycling without the cyclosome: modeling a yeast strain lacking the APC. Cell Cycle. 2004 May; 3(5):629-33.
Thornton BR, Chen KC, Cross FR, Tyson JJ, Toczyski DP. PMID: 15034296.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Securin and B-cyclin/CDK are the only essential targets of the APC. Nat Cell Biol. 2003 Dec; 5(12):1090-4.
Thornton BR, Toczyski DP. PMID: 14634663.
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PubMed Mentions:
93 Fields:
Translation:
Animals
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A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol. 2002 Apr; 14(2):237-45.
Melo J, Toczyski D. PMID: 11891124.
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PubMed Mentions:
175 Fields:
Translation:
HumansAnimalsCells
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Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 2001 Nov 01; 15(21):2809-21.
Melo JA, Cohen J, Toczyski DP. PMID: 11691833; PMCID: PMC312815.
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PubMed Mentions:
161 Fields:
Translation:
Cells
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Checkpoint adaptation precedes spontaneous and damage-induced genomic instability in yeast. Mol Cell Biol. 2001 Mar; 21(5):1710-8.
Galgoczy DJ, Toczyski DP. PMID: 11238908; PMCID: PMC86717.
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PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell. 1997 Sep 19; 90(6):1097-106.
Toczyski DP, Galgoczy DJ, Hartwell LH. PMID: 9323137.
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PubMed Mentions:
184 Fields:
Translation:
Animals
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When checkpoints fail. Cell. 1997 Feb 07; 88(3):315-21.
Paulovich AG, Toczyski DP, Hartwell LH. PMID: 9039258.
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PubMed Mentions:
154 Fields:
Translation:
HumansAnimalsCells
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The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3463-7.
Toczyski DP, Matera AG, Ward DC, Steitz JA. PMID: 8159770; PMCID: PMC43597.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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The cellular RNA-binding protein EAP recognizes a conserved stem-loop in the Epstein-Barr virus small RNA EBER 1. Mol Cell Biol. 1993 Jan; 13(1):703-10.
Toczyski DP, Steitz JA. PMID: 8380232; PMCID: PMC358948.
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PubMed Mentions:
26 Fields:
Translation:
Cells
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EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). EMBO J. 1991 Feb; 10(2):459-66.
Toczyski DP, Steitz JA. PMID: 1846807; PMCID: PMC452667.
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PubMed Mentions:
48 Fields:
Translation:
HumansCells