Loading...

David Toczyski, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentHDF Comprehensive Cancer Ctr
Address1450 Third St
San Francisco CA 94158
Phone415-502-1301
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation by post-translation modifications in response to stress
    NIH/NIGMS R35GM118104May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Identifying the targets of oncogenic/tumor-suppressive F box proteins
    NIH/NCI R21CA187685Apr 1, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Yeast Chromosome Structure, Replication and Segregation
    NIH/NICHD R13HD053182Mar 1, 2006 - Feb 28, 2011
    Role: Principal Investigator
    Cell cycle regulation by ubiquitin ligases
    NIH/NIGMS R01GM070539Jun 1, 2004 - Apr 30, 2016
    Role: Principal Investigator
    Regulation and Targets of the DNA Damage Checkpoint
    NIH/NIGMS R01GM059691Aug 1, 1999 - Aug 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Mark KG, Loveless TB, Toczyski D. Isolation of ubiquitinated substrates by tandem affinity purification of E3 ligase-polyubiquitin-binding domain fusions (ligase traps). Nat Protoc. 2016 Feb; 11(2):291-301. PMID: 26766115.
      View in: PubMed
    2. Meza-Gutierrez F, Hundley FV, Toczyski D. Parallel Parkin: Cdc20 Takes a New Partner. Mol Cell. 2015 Oct 01; 60(1):3-4. PMID: 26431023.
      View in: PubMed
    3. Mark KG, Meza-Gutierrez F, Johnson JR, Newton BW, Krogan NJ, Toczyski D. Prb1 Protease Activity Is Required for Its Recognition by the F-Box Protein Saf1. Biochemistry. 2015 Jul 28; 54(29):4423-6. PMID: 26161950; PMCID: PMC4816488.
    4. Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski D. DNA Damage Regulates Translation through ß-TRCP Targeting of CReP. PLoS Genet. 2015 Jun; 11(6):e1005292. PMID: 26091241; PMCID: PMC4474599.
    5. Edenberg ER, Mark KG, Toczyski D. Ndd1 turnover by SCF(Grr1) is inhibited by the DNA damage checkpoint in Saccharomyces cerevisiae. PLoS Genet. 2015 Apr; 11(4):e1005162. PMID: 25894965; PMCID: PMC4403921.
    6. Downey M, Johnson JR, Davey NE, Newton BW, Johnson TL, Galaang S, Seller CA, Krogan N, Toczyski D. Acetylome profiling reveals overlap in the regulation of diverse processes by sirtuins, gcn5, and esa1. Mol Cell Proteomics. 2015 Jan; 14(1):162-76. PMID: 25381059; PMCID: PMC4288252.
    7. Edenberg ER, Downey M, Toczyski D. Polymerase stalling during replication, transcription and translation. Curr Biol. 2014 May 19; 24(10):R445-52. PMID: 24845677.
      View in: PubMed
    8. Edenberg ER, Vashisht AA, Topacio BR, Wohlschlegel JA, Toczyski D. Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5962-7. PMID: 24715726; PMCID: PMC4000829.
    9. Mark KG, Simonetta M, Maiolica A, Seller CA, Toczyski D. Ubiquitin ligase trapping identifies an SCF(Saf1) pathway targeting unprocessed vacuolar/lysosomal proteins. Mol Cell. 2014 Jan 09; 53(1):148-61. PMID: 24389104; PMCID: PMC4032118.
    10. Edenberg ER, Vashisht A, Benanti JA, Wohlschlegel J, Toczyski D. Rad53 downregulates mitotic gene transcription by inhibiting the transcriptional activator Ndd1. Mol Cell Biol. 2014 Feb; 34(4):725-38. PMID: 24324011; PMCID: PMC3911491.
    11. Downey M, Knight B, Vashisht AA, Seller CA, Wohlschlegel JA, Shore D, Toczyski D. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol. 2013 Sep 09; 23(17):1638-48. PMID: 23973296; PMCID: PMC3982851.
    12. Landry BD, Doyle JP, Toczyski D, Benanti JA. F-box protein specificity for g1 cyclins is dictated by subcellular localization. PLoS Genet. 2012; 8(7):e1002851. PMID: 22844257; PMCID: PMC3405998.
    13. Foe IT, Toczyski D. Ubiquitin ligases: Taming the APC. Nat Chem Biol. 2012 Mar 16; 8(4):323-4. PMID: 22426190.
      View in: PubMed
    14. Berens TJ, Toczyski D. Keeping it together in times of stress: checkpoint function at stalled replication forks. Mol Cell. 2012 Mar 09; 45(5):585-6. PMID: 22405272; PMCID: PMC3694131.
    15. Berens TJ, Toczyski D. Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo. Mol Biol Cell. 2012 Mar; 23(6):1058-67. PMID: 22298423; PMCID: PMC3302733.
    16. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski D. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7. PMID: 22079111; PMCID: PMC3430386.
    17. Foe I, Toczyski D. Structural biology: a new look for the APC. Nature. 2011 Feb 10; 470(7333):182-3. PMID: 21307929.
      View in: PubMed
    18. Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21; 6:451. PMID: 21179023; PMCID: PMC3018166.
    19. Lopez-Mosqueda J, Vidanes GM, Toczyski D. Cdc5 blocks in vivo Rad53 activity, but not in situ activity (ISA). Cell Cycle. 2010 Nov 01; 9(21):4266-8. PMID: 20962588; PMCID: PMC3055179.
    20. Lopez-Mosqueda J, Maas NL, Jonsson ZO, Defazio-Eli LG, Wohlschlegel J, Toczyski D. Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature. 2010 Sep 23; 467(7314):479-83. PMID: 20865002; PMCID: PMC3393088.
    21. Downey M, Edenberg ER, Toczyski D. Repair scaffolding reaches new heights at blocked replication forks. Mol Cell. 2010 Jul 30; 39(2):162-4. PMID: 20670884.
      View in: PubMed
    22. Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski D. CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. PLoS Biol. 2010 Jan 26; 8(1):e1000286. PMID: 20126259; PMCID: PMC2811153.
    23. Benanti JA, Matyskiela ME, Morgan DO, Toczyski D. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90. PMID: 19285942; PMCID: PMC2883288.
    24. Benanti JA, Toczyski D. Cdc20, an activator at last. Mol Cell. 2008 Nov 21; 32(4):460-1. PMID: 19026776; PMCID: PMC2880502.
    25. Bonilla CY, Melo JA, Toczyski D. Colocalization of sensors is sufficient to activate the DNA damage checkpoint in the absence of damage. Mol Cell. 2008 May 09; 30(3):267-76. PMID: 18471973; PMCID: PMC2879338.
    26. Benanti JA, Cheung SK, Brady MC, Toczyski D. A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch. Nat Cell Biol. 2007 Oct; 9(10):1184-91. PMID: 17828247.
      View in: PubMed
    27. Vega LR, Phillips JA, Thornton BR, Benanti JA, Onigbanjo MT, Toczyski D, Zakian VA. Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. PLoS Genet. 2007 Jun; 3(6):e105. PMID: 17590086; PMCID: PMC1892048.
    28. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski D, Weissman JS, Greenblatt JF, Krogan NJ. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10. PMID: 17314980.
      View in: PubMed
    29. Thornton BR, Toczyski D. Precise destruction: an emerging picture of the APC. Genes Dev. 2006 Nov 15; 20(22):3069-78. PMID: 17114580.
      View in: PubMed
    30. Miller KM, Maas NL, Toczyski D. Taking it off: regulation of H3 K56 acetylation by Hst3 and Hst4. Cell Cycle. 2006 Nov; 5(22):2561-5. PMID: 17106263.
      View in: PubMed
    31. Maas NL, Miller KM, DeFazio LG, Toczyski D. Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4. Mol Cell. 2006 Jul 07; 23(1):109-19. PMID: 16818235.
      View in: PubMed
    32. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski D. An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60. PMID: 16481473; PMCID: PMC1369047.
    33. Toczyski D. Methods for studying adaptation to the DNA damage checkpoint in yeast. Methods Enzymol. 2006; 409:150-65. PMID: 16793400.
      View in: PubMed
    34. Vidanes GM, Bonilla CY, Toczyski D. Complicated tails: histone modifications and the DNA damage response. Cell. 2005 Jul 01; 121(7):973-6. PMID: 15989948.
      View in: PubMed
    35. Garber PM, Vidanes GM, Toczyski D. Damage in transition. Trends Biochem Sci. 2005 Feb; 30(2):63-6. PMID: 15691649.
      View in: PubMed
    36. Kaye JA, Melo JA, Cheung SK, Vaze MB, Haber JE, Toczyski D. DNA breaks promote genomic instability by impeding proper chromosome segregation. Curr Biol. 2004 Dec 14; 14(23):2096-106. PMID: 15589151.
      View in: PubMed
    37. Thornton BR, Chen KC, Cross FR, Tyson JJ, Toczyski D. Cycling without the cyclosome: modeling a yeast strain lacking the APC. Cell Cycle. 2004 May; 3(5):629-33. PMID: 15034296.
      View in: PubMed
    38. Thornton BR, Toczyski D. Securin and B-cyclin/CDK are the only essential targets of the APC. Nat Cell Biol. 2003 Dec; 5(12):1090-4. PMID: 14634663.
      View in: PubMed
    39. Melo J, Toczyski D. A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol. 2002 Apr; 14(2):237-45. PMID: 11891124.
      View in: PubMed
    40. Melo JA, Cohen J, Toczyski D. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev. 2001 Nov 01; 15(21):2809-21. PMID: 11691833; PMCID: PMC312815.
    41. Galgoczy DJ, Toczyski D. Checkpoint adaptation precedes spontaneous and damage-induced genomic instability in yeast. Mol Cell Biol. 2001 Mar; 21(5):1710-8. PMID: 11238908; PMCID: PMC86717.
    42. Toczyski D, Galgoczy DJ, Hartwell LH. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell. 1997 Sep 19; 90(6):1097-106. PMID: 9323137.
      View in: PubMed
    43. Paulovich AG, Toczyski D, Hartwell LH. When checkpoints fail. Cell. 1997 Feb 07; 88(3):315-21. PMID: 9039258.
      View in: PubMed
    44. Toczyski D, Matera AG, Ward DC, Steitz JA. The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3463-7. PMID: 8159770; PMCID: PMC43597.
    45. Toczyski D, Steitz JA. The cellular RNA-binding protein EAP recognizes a conserved stem-loop in the Epstein-Barr virus small RNA EBER 1. Mol Cell Biol. 1993 Jan; 13(1):703-10. PMID: 8380232; PMCID: PMC358948.
    46. Toczyski D, Steitz JA. EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs). EMBO J. 1991 Feb; 10(2):459-66. PMID: 1846807; PMCID: PMC452667.
    David's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP