David Morgan, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1986 Graduate Division (Endocrinology)

    Collapse Research 
    Collapse Research Activities and Funding
    Regulatory Enzymes and Systems in Cell Cycle Control
    NIH/NIGMS R35GM118053May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Quantitative studies of cell cycle checkpoints and switches
    NIH/NIGMS R01GM097115Aug 8, 2011 - May 31, 2015
    Role: Principal Investigator
    Regulation of chromosome segregation
    NIH/NIGMS R01GM094173Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator
    Cell Cycle Control by Cyclin-Dependent Kinases
    NIH/NIGMS R01GM069901Jan 1, 2004 - Mar 31, 2016
    Role: Principal Investigator
    NIH/NCI R13CA072052Jun 14, 1996 - Jun 13, 1997
    Role: Principal Investigator
    NIH/NIGMS R01GM050684May 1, 1994 - Dec 31, 2003
    Role: Principal Investigator
    Molecular Control of Cell Proliferation
    NIH/NIGMS R37GM053270Aug 3, 1990 - Aug 31, 2016
    Role: Principal Investigator
    Molecular Control of Cell Proliferation
    NIH/NIGMS R01GM053270Aug 3, 1990 - Aug 31, 2011
    Role: Principal Investigator
    NIH/NCI R01CA052481Aug 3, 1990 - Jun 30, 1995
    Role: Principal Investigator
    Cell Biology, Genetics, and Biochemistry Training Grant
    NIH/NIGMS T32GM007810Jul 1, 1979 - Jun 30, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Seoane AI, Morgan DO. Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction. Curr Biol. 2017 Sep 25; 27(18):2849-2855.e2. PMID: 28918948.
      View in: PubMed
    2. Davey NE, Morgan DO. Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex. Mol Cell. 2016 10 06; 64(1):12-23. PMID: 27716480.
      View in: PubMed
    3. Morgan DO. Cell division: Mitotic regulation comes into focus. Nature. 2016 08 25; 536(7617):407-8. PMID: 27509855.
      View in: PubMed
    4. Galli M, Morgan DO. Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development. Dev Cell. 2016 Feb 08; 36(3):344-52. PMID: 26859356; PMCID: PMC4748171 [Available on 02/08/17].
    5. Lu D, Girard JR, Li W, Mizrak A, Morgan DO. Quantitative framework for ordered degradation of APC/C substrates. BMC Biol. 2015 Nov 16; 13:96. PMID: 26573515.
      View in: PubMed
    6. Girard JR, Tenthorey JL, Morgan DO. An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition. J Biol Chem. 2015 Oct 02; 290(40):24614-25. PMID: 26306044.
      View in: PubMed
    7. Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol. 2014 Oct 13; 207(1):23-39. PMID: 25287299; PMCID: PMC4195823.
    8. Eshleman HD, Morgan DO. Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis. J Cell Sci. 2014 Nov 15; 127(Pt 22):4974-83. PMID: 25236599; PMCID: PMC4231310.
    9. Matsusaka T, Enquist-Newman M, Morgan DO, Pines J. Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate. Biol Open. 2014 Sep 12; 3(10):904-12. PMID: 25217616.
      View in: PubMed
    10. Van Voorhis VA, Morgan DO. Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr Biol. 2014 Jul 07; 24(13):1556-62. PMID: 24930963; PMCID: PMC4090254.
    11. Naylor SG, Morgan DO. Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci. 2014 Mar 01; 127(Pt 5):1128-37. PMID: 24413167; PMCID: PMC3937778.
    12. Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc. 2013 Dec 04; 135(48):18153-9. PMID: 24171479; PMCID: PMC3938282.
    13. Morgan DO. The D box meets its match. Mol Cell. 2013 Jun 06; 50(5):609-10. PMID: 23746347; PMCID: PMC3702177.
    14. Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO. Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol. 2013 Feb; 20(2):194-201. PMID: 23314252; PMCID: PMC3565030.
    15. Foster SA, Morgan DO. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012 Sep 28; 47(6):921-32. PMID: 22940250; PMCID: PMC3462283.
    16. Yaakov G, Thorn K, Morgan DO. Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell. 2012 Jul 17; 23(1):124-36. PMID: 22814605; PMCID: PMC3413326.
    17. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7. PMID: 22079111; PMCID: PMC3430386.
    18. Schaefer JB, Morgan DO. Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem. 2011 Dec 30; 286(52):45186-96. PMID: 22072716; PMCID: PMC3247991.
    19. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature. 2011 Oct 12; 480(7375):128-31. PMID: 21993622; PMCID: PMC3228899.
    20. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell. 2011 Jun 10; 42(5):610-23. PMID: 21658602; PMCID: PMC3115021.
    21. Lyons NA, Morgan DO. Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell. 2011 May 06; 42(3):378-89. PMID: 21549314; PMCID: PMC3095509.
    22. Rodrigo-Brenni MC, Foster SA, Morgan DO. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell. 2010 Aug 27; 39(4):548-59. PMID: 20797627; PMCID: PMC2929935.
    23. Morgan DO. The hidden rhythms of the dividing cell. Cell. 2010 Apr 16; 141(2):224-6. PMID: 20403319.
      View in: PubMed
    24. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nat Cell Biol. 2009 Nov; 11(11):1275-6. PMID: 19884882; PMCID: PMC2914104.
    25. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6. PMID: 19779198; PMCID: PMC2813701.
    26. Matyskiela ME, Morgan DO. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell. 2009 Apr 10; 34(1):68-80. PMID: 19362536; PMCID: PMC2754851.
    27. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90. PMID: 19285942; PMCID: PMC2883288.
    28. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO. Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol. 2009; 8(10):92. PMID: 19874575; PMCID: PMC2790831.
    29. Tully GH, Nishihama R, Pringle JR, Morgan DO. The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell. 2009 Feb; 20(4):1201-12. PMID: 19109423.
      View in: PubMed
    30. Morgan DO. SnapShot: Cell-cycle regulators II. Cell. 2008 Nov 28; 135(5):974-974.e1. PMID: 19041757.
      View in: PubMed
    31. Morgan DO. SnapShot: cell-cycle regulators I. Cell. 2008 Nov 14; 135(4):764-764.e1. PMID: 19013283.
      View in: PubMed
    32. Sullivan M, Holt L, Morgan DO. Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol. 2008 Sep; 28(17):5328-36. PMID: 18591250; PMCID: PMC2519743.
    33. Holt LJ, Krutchinsky AN, Morgan DO. Positive feedback sharpens the anaphase switch. Nature. 2008 Jul 17; 454(7202):353-7. PMID: 18552837; PMCID: PMC2636747.
    34. Enquist-Newman M, Sullivan M, Morgan DO. Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell. 2008 May 23; 30(4):437-46. PMID: 18498748; PMCID: PMC2494983.
    35. Blethrow JD, Glavy JS, Morgan DO, Shokat KM. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1442-7. PMID: 18234856; PMCID: PMC2234163.
    36. Sullivan M, Morgan DO. Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol. 2007 Nov; 8(11):894-903. PMID: 17912263.
      View in: PubMed
    37. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. PMID: 18022565; PMCID: PMC2215327.
    38. Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR. Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell. 2007 Dec; 18(12):5139-53. PMID: 17942599.
      View in: PubMed
    39. Woodbury EL, Morgan DO. The role of self-association in Fin1 function on the mitotic spindle. J Biol Chem. 2007 Nov 02; 282(44):32138-43. PMID: 17804403.
      View in: PubMed
    40. Rodrigo-Brenni MC, Morgan DO. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell. 2007 Jul 13; 130(1):127-39. PMID: 17632060.
      View in: PubMed
    41. Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7. PMID: 17589519.
      View in: PubMed
    42. Sullivan M, Morgan DO. A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem. 2007 Jul 06; 282(27):19710-5. PMID: 17493939.
      View in: PubMed
    43. Holt LJ, Hutti JE, Cantley LC, Morgan DO. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell. 2007 Mar 09; 25(5):689-702. PMID: 17349956; PMCID: PMC1939968.
    44. Woodbury EL, Morgan DO. Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol. 2007 Jan; 9(1):106-12. PMID: 17173039.
      View in: PubMed
    45. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60. PMID: 16481473; PMCID: PMC1369047.
    46. Loog M, Morgan DO. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature. 2005 Mar 03; 434(7029):104-8. PMID: 15744308.
      View in: PubMed
    47. Carroll CW, Enquist-Newman M, Morgan DO. The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol. 2005 Jan 11; 15(1):11-8. PMID: 15649358.
      View in: PubMed
    48. Carroll CW, Morgan DO. Enzymology of the anaphase-promoting complex. Methods Enzymol. 2005; 398:219-30. PMID: 16275331.
      View in: PubMed
    49. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003 Oct 23; 425(6960):859-64. PMID: 14574415.
      View in: PubMed
    50. Carroll CW, Morgan DO. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol. 2002 Nov; 4(11):880-7. PMID: 12402045.
      View in: PubMed
    51. Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat KM. Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc. 2002 Oct 16; 124(41):12118-28. PMID: 12371851.
      View in: PubMed
    52. Morgan DO, Roberts JM. Oscillation sensation. Nature. 2002 Aug 01; 418(6897):495-6. PMID: 12152065.
      View in: PubMed