David Morgan, PhD

Title(s)Professor, Physiology
SchoolSchool of Medicine
Address600 16th St, #N312B
San Francisco CA 94158
Phone415-476-6695
ORCID ORCID Icon0000-0001-8753-4416 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of CalgaryB.Sc.1980Animal Biology
    University of California, San FranciscoPh.D.1986 Graduate Division (Endocrinology)

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Regulatory Enzymes and Systems in Cell Cycle Control
    NIH R35GM118053May 1, 2016 - Apr 30, 2026
    Role: Principal Investigator
    Quantitative studies of cell cycle checkpoints and switches
    NIH R01GM097115Aug 8, 2011 - May 31, 2015
    Role: Principal Investigator
    Regulation of chromosome segregation
    NIH R01GM094173Sep 1, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Cell Cycle Control by Cyclin-Dependent Kinases
    NIH R01GM069901Jan 1, 2004 - Mar 31, 2017
    Role: Principal Investigator
    MOLECULAR CELL BIOLOGY CONFERENCE
    NIH R13CA072052Jun 14, 1996 - Jun 13, 1997
    Role: Principal Investigator
    STRUCTURE/FUNCTION OF CYCLIN DEPENDENT KINASES
    NIH R01GM050684May 1, 1994 - Dec 31, 2003
    Role: Principal Investigator
    Molecular Control of Cell Proliferation
    NIH R37GM053270Aug 3, 1990 - Aug 31, 2016
    Role: Principal Investigator
    Molecular Control of Cell Proliferation
    NIH R01GM053270Aug 3, 1990 - Aug 31, 2011
    Role: Principal Investigator
    MOLECULAR CONTROL OF CELL PROLIFERATION
    NIH R01CA052481Aug 3, 1990 - Jun 30, 1995
    Role: Principal Investigator
    Cell Biology, Genetics, and Biochemistry Training Grant
    NIH T32GM007810Jul 1, 1979 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing. bioRxiv. 2024 Feb 29. Ng HY, Adly AN, Whelpley DH, Suhandynata RT, Zhou H, Morgan DO. PMID: 38464173; PMCID: PMC10925351.
      View in: PubMed   Mentions:
    2. Assembly of SARS-CoV-2 ribonucleosomes by truncated N∗ variant of the nucleocapsid protein. J Biol Chem. 2023 Dec; 299(12):105362. Adly AN, Bi M, Carlson CR, Syed AM, Ciling A, Doudna JA, Cheng Y, Morgan DO. PMID: 37863261; PMCID: PMC10665939.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. The molecular mechanisms of human separase regulation. Biochem Soc Trans. 2023 06 28; 51(3):1225-1233. Yu J, Morgan DO, Boland A. PMID: 37140261; PMCID: PMC10317155.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation. J Biol Chem. 2022 11; 298(11):102560. Carlson CR, Adly AN, Bi M, Howard CJ, Frost A, Cheng Y, Morgan DO. PMID: 36202211; PMCID: PMC9529352.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    5. Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation. bioRxiv. 2022 May 24. Carlson CR, Adly AN, Bi M, Cheng Y, Morgan DO. PMID: 35664996; PMCID: PMC9164447.
      View in: PubMed   Mentions:
    6. Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C. Nat Commun. 2022 01 17; 13(1):341. Hartooni N, Sung J, Jain A, Morgan DO. PMID: 35039540; PMCID: PMC8764033.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription. Curr Biol. 2022 01 10; 32(1):256-263.e4. Asfaha JB, Örd M, Carlson CR, Faustova I, Loog M, Morgan DO. PMID: 34818519; PMCID: PMC8752490.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature. 2021 08; 596(7870):138-142. Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A. PMID: 34290405; PMCID: PMC8482764.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    9. Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions. Mol Cell. 2020 12 17; 80(6):1092-1103.e4. Carlson CR, Asfaha JB, Ghent CM, Howard CJ, Hartooni N, Safari M, Frankel AD, Morgan DO. PMID: 33248025; PMCID: PMC7677695.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansCells
    10. Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein. bioRxiv. 2020 Jun 29. Carlson CR, Asfaha JB, Ghent CM, Howard CJ, Hartooni N, Morgan DO. PMID: 32637943; PMCID: PMC7337373.
      View in: PubMed   Mentions: 2  
    11. Polyanions provide selective control of APC/C interactions with the activator subunit. Nat Commun. 2019 12 20; 10(1):5807. Mizrak A, Morgan DO. PMID: 31862931; PMCID: PMC6925294.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site. Nat Commun. 2019 11 15; 10(1):5189. Rosen LE, Klebba JE, Asfaha JB, Ghent CM, Campbell MG, Cheng Y, Morgan DO. PMID: 31729382; PMCID: PMC6858450.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function. J Biol Chem. 2019 11 15; 294(46):17249-17261. Qin L, Mizrak A, Guimarães DSPSF, Tambrin HM, Morgan DO, Hall MC. PMID: 31562243; PMCID: PMC6873173.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction. Curr Biol. 2017 Sep 25; 27(18):2849-2855.e2. Seoane AI, Morgan DO. PMID: 28918948; PMCID: PMC5639876.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex. Mol Cell. 2016 10 06; 64(1):12-23. Davey NE, Morgan DO. PMID: 27716480; PMCID: PMC5098475.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    16. Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development. Dev Cell. 2016 Feb 08; 36(3):344-52. Galli M, Morgan DO. PMID: 26859356; PMCID: PMC4748171.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    17. Quantitative framework for ordered degradation of APC/C substrates. BMC Biol. 2015 Nov 16; 13:96. Lu D, Girard JR, Li W, Mizrak A, Morgan DO. PMID: 26573515; PMCID: PMC4647693.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    18. An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition. J Biol Chem. 2015 Oct 02; 290(40):24614-25. Girard JR, Tenthorey JL, Morgan DO. PMID: 26306044; PMCID: PMC4591839.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol. 2014 Oct 13; 207(1):23-39. Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO. PMID: 25287299; PMCID: PMC4195823.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    20. Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis. J Cell Sci. 2014 Nov 15; 127(Pt 22):4974-83. Eshleman HD, Morgan DO. PMID: 25236599; PMCID: PMC4231310.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    21. Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr Biol. 2014 Jul 07; 24(13):1556-62. Van Voorhis VA, Morgan DO. PMID: 24930963; PMCID: PMC4090254.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    22. Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci. 2014 Mar 01; 127(Pt 5):1128-37. Naylor SG, Morgan DO. PMID: 24413167; PMCID: PMC3937778.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. The D box meets its match. Mol Cell. 2013 Jun 06; 50(5):609-10. Morgan DO. PMID: 23746347; PMCID: PMC3702177.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    24. Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol. 2013 Feb; 20(2):194-201. Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO. PMID: 23314252; PMCID: PMC3565030.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    25. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012 Sep 28; 47(6):921-32. Foster SA, Morgan DO. PMID: 22940250; PMCID: PMC3462283.
      View in: PubMed   Mentions: 69     Fields:    Translation:Cells
    26. Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell. 2012 Jul 17; 23(1):124-36. Yaakov G, Thorn K, Morgan DO. PMID: 22814605; PMCID: PMC3413326.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    27. Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr Biol. 2011 Nov 22; 21(22):1870-7. Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP. PMID: 22079111; PMCID: PMC3430386.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    28. Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem. 2011 Dec 30; 286(52):45186-96. Schaefer JB, Morgan DO. PMID: 22072716; PMCID: PMC3247991.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    29. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature. 2011 Oct 12; 480(7375):128-31. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M. PMID: 21993622; PMCID: PMC3228899.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    30. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell. 2011 Jun 10; 42(5):610-23. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. PMID: 21658602; PMCID: PMC3115021.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    31. Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell. 2011 May 06; 42(3):378-89. Lyons NA, Morgan DO. PMID: 21549314; PMCID: PMC3095509.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    32. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell. 2010 Aug 27; 39(4):548-59. Rodrigo-Brenni MC, Foster SA, Morgan DO. PMID: 20797627; PMCID: PMC2929935.
      View in: PubMed   Mentions: 58     Fields:    Translation:Cells
    33. The hidden rhythms of the dividing cell. Cell. 2010 Apr 16; 141(2):224-6. Morgan DO. PMID: 20403319.
      View in: PubMed   Mentions: 5     Fields:    
    34. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. PMID: 19779198; PMCID: PMC2813701.
      View in: PubMed   Mentions: 521     Fields:    Translation:AnimalsCells
    35. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell. 2009 Apr 10; 34(1):68-80. Matyskiela ME, Morgan DO. PMID: 19362536; PMCID: PMC2754851.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    36. Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell. 2009 Mar 13; 33(5):581-90. Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP. PMID: 19285942; PMCID: PMC2883288.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    37. Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol. 2009; 8(10):92. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO. PMID: 19874575; PMCID: PMC2790831.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    38. The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell. 2009 Feb; 20(4):1201-12. Tully GH, Nishihama R, Pringle JR, Morgan DO. PMID: 19109423; PMCID: PMC2642741.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    39. SnapShot: Cell-cycle regulators II. Cell. 2008 Nov 28; 135(5):974-974.e1. Morgan DO. PMID: 19041757.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    40. SnapShot: cell-cycle regulators I. Cell. 2008 Nov 14; 135(4):764-764.e1. Morgan DO. PMID: 19013283.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    41. Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol. 2008 Sep; 28(17):5328-36. Sullivan M, Holt L, Morgan DO. PMID: 18591250; PMCID: PMC2519743.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    42. Positive feedback sharpens the anaphase switch. Nature. 2008 Jul 17; 454(7202):353-7. Holt LJ, Krutchinsky AN, Morgan DO. PMID: 18552837; PMCID: PMC2636747.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    43. Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell. 2008 May 23; 30(4):437-46. Enquist-Newman M, Sullivan M, Morgan DO. PMID: 18498748; PMCID: PMC2494983.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    44. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1442-7. Blethrow JD, Glavy JS, Morgan DO, Shokat KM. PMID: 18234856; PMCID: PMC2234163.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCells
    45. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. PMID: 18022565; PMCID: PMC2215327.
      View in: PubMed   Mentions: 59     Fields:    
    46. Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol. 2007 Nov; 8(11):894-903. Sullivan M, Morgan DO. PMID: 17912263.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    47. Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell. 2007 Dec; 18(12):5139-53. Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR. PMID: 17942599; PMCID: PMC2096582.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    48. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell. 2007 Jul 13; 130(1):127-39. Rodrigo-Brenni MC, Morgan DO. PMID: 17632060.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    49. A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem. 2007 Jul 06; 282(27):19710-5. Sullivan M, Morgan DO. PMID: 17493939.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    50. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell. 2007 Mar 09; 25(5):689-702. Holt LJ, Hutti JE, Cantley LC, Morgan DO. PMID: 17349956; PMCID: PMC1939968.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    51. Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol. 2007 Jan; 9(1):106-12. Woodbury EL, Morgan DO. PMID: 17173039.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    52. An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. PMID: 16481473; PMCID: PMC1369047.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    53. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature. 2005 Mar 03; 434(7029):104-8. Loog M, Morgan DO. PMID: 15744308.
      View in: PubMed   Mentions: 192     Fields:    Translation:AnimalsCells
    54. The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol. 2005 Jan 11; 15(1):11-8. Carroll CW, Enquist-Newman M, Morgan DO. PMID: 15649358.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    55. Enzymology of the anaphase-promoting complex. Methods Enzymol. 2005; 398:219-30. Carroll CW, Morgan DO. PMID: 16275331.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003 Oct 23; 425(6960):859-64. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. PMID: 14574415.
      View in: PubMed   Mentions: 456     Fields:    Translation:AnimalsCells
    57. Oscillation sensation. Nature. 2002 Aug 01; 418(6897):495-6. Morgan DO, Roberts JM. PMID: 12152065.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
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