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David Morgan, PhD

Photo of David Morgan, PhD
Title(s)Professor, Physiology
SchoolSchool of Medicine
Address600 16th Street, #N312B
San Francisco CA 94158
Phone415-476-6695
ORCID ORCID Icon0000-0001-8753-4416 Additional info
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    Collapse Biography 
    Collapse education and training
    University of CalgaryB.Sc.1980Animal Biology
    University of California, San FranciscoPh.D.1986 Graduate Division (Endocrinology)

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Regulatory Enzymes and Systems in Cell Cycle Control
    NIH R35GM118053May 1, 2016 - Apr 30, 2026
    Role: Principal Investigator
    Quantitative studies of cell cycle checkpoints and switches
    NIH R01GM097115Aug 8, 2011 - May 31, 2015
    Role: Principal Investigator
    Regulation of chromosome segregation
    NIH R01GM094173Sep 1, 2010 - Aug 31, 2015
    Role: Principal Investigator
    Cell Cycle Control by Cyclin-Dependent Kinases
    NIH R01GM069901Jan 1, 2004 - Mar 31, 2017
    Role: Principal Investigator
    MOLECULAR CELL BIOLOGY CONFERENCE
    NIH R13CA072052Jun 14, 1996 - Jun 13, 1997
    Role: Principal Investigator
    STRUCTURE/FUNCTION OF CYCLIN DEPENDENT KINASES
    NIH R01GM050684May 1, 1994 - Dec 31, 2003
    Role: Principal Investigator
    Molecular Control of Cell Proliferation
    NIH R37GM053270Aug 3, 1990 - Aug 31, 2016
    Role: Principal Investigator
    Molecular Control of Cell Proliferation
    NIH R01GM053270Aug 3, 1990 - Aug 31, 2011
    Role: Principal Investigator
    MOLECULAR CONTROL OF CELL PROLIFERATION
    NIH R01CA052481Aug 3, 1990 - Jun 30, 1995
    Role: Principal Investigator
    Cell Biology, Genetics, and Biochemistry Training Grant
    NIH T32GM007810Jul 1, 1979 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Substrate recognition by human separase. Sci Adv. 2025 Nov 14; 11(46):eady9807. Yu J, Schmidt S, Botto M, Lee K, Ghent CM, Goodfried JM, Howe A, O'Reilly FJ, Morgan DO, Boland A. PMID: 41223273; PMCID: PMC12609080.
      View in: PubMed   Mentions:
    2. Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis. Curr Biol. 2025 Aug 18; 35(16):3943-3958.e5. Haase J, Aktar K, Bonner MK, Colin L, Gupta H, Marinoni BE, Morgan DO, Kelly AE. PMID: 40730158; PMCID: PMC12313260.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors. Sci Adv. 2025 May 16; 11(20):eadq3858. Garcia JQ, Mouilleau V, Ng H, Zhao X, Morgan DO, Guo S. PMID: 40367180; PMCID: PMC12077515.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing. Nat Commun. 2025 May 08; 16(1):4281. Ng HY, Whelpley DH, Adly AN, Maxwell RA, Morgan DO. PMID: 40341598; PMCID: PMC12062237.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation. PLoS Pathog. 2024 Nov; 20(11):e1012741. Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, Taha TY, Khalid MM, Price N, Bouhaddou M, Ummadi MR, Moen JM, Krogan NJ, Morgan DO, Ott M, Doudna JA. PMID: 39571001; PMCID: PMC11620656.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Institutional Conversion to Energy-Efficient Ultra-Low Freezers Decreases Carbon Footprint and Reduces Energy Costs. Biopreserv Biobank. 2025 Jun; 23(3):195-202. Shehu D, Kim MO, Rosendo J, Krogan N, Morgan DO, Guglielmo BJ. PMID: 39321093.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Assembly of SARS-CoV-2 ribonucleosomes by truncated N∗ variant of the nucleocapsid protein. J Biol Chem. 2023 12; 299(12):105362. Adly AN, Bi M, Carlson CR, Syed AM, Ciling A, Doudna JA, Cheng Y, Morgan DO. PMID: 37863261; PMCID: PMC10665939.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    8. The molecular mechanisms of human separase regulation. Biochem Soc Trans. 2023 06 28; 51(3):1225-1233. Yu J, Morgan DO, Boland A. PMID: 37140261; PMCID: PMC10317155.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    9. Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation. J Biol Chem. 2022 11; 298(11):102560. Carlson CR, Adly AN, Bi M, Howard CJ, Frost A, Cheng Y, Morgan DO. PMID: 36202211; PMCID: PMC9529352.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    10. Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C. Nat Commun. 2022 01 17; 13(1):341. Hartooni N, Sung J, Jain A, Morgan DO. PMID: 35039540; PMCID: PMC8764033.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription. Curr Biol. 2022 01 10; 32(1):256-263.e4. Asfaha JB, Örd M, Carlson CR, Faustova I, Loog M, Morgan DO. PMID: 34818519; PMCID: PMC8752490.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    12. Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature. 2021 08; 596(7870):138-142. Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A. PMID: 34290405; PMCID: PMC8482764.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    13. Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions. Mol Cell. 2020 12 17; 80(6):1092-1103.e4. Carlson CR, Asfaha JB, Ghent CM, Howard CJ, Hartooni N, Safari M, Frankel AD, Morgan DO. PMID: 33248025; PMCID: PMC7677695.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansCells
    14. Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein. bioRxiv. 2020 Jun 29. Carlson CR, Asfaha JB, Ghent CM, Howard CJ, Hartooni N, Morgan DO. PMID: 32637943; PMCID: PMC7337373.
      View in: PubMed   Mentions: 2  
    15. Polyanions provide selective control of APC/C interactions with the activator subunit. Nat Commun. 2019 12 20; 10(1):5807. Mizrak A, Morgan DO. PMID: 31862931; PMCID: PMC6925294.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site. Nat Commun. 2019 11 15; 10(1):5189. Rosen LE, Klebba JE, Asfaha JB, Ghent CM, Campbell MG, Cheng Y, Morgan DO. PMID: 31729382; PMCID: PMC6858450.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    17. The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function. J Biol Chem. 2019 11 15; 294(46):17249-17261. Qin L, Mizrak A, Guimarães DSPSF, Tambrin HM, Morgan DO, Hall MC. PMID: 31562243; PMCID: PMC6873173.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    18. Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction. Curr Biol. 2017 Sep 25; 27(18):2849-2855.e2. Seoane AI, Morgan DO. PMID: 28918948; PMCID: PMC5639876.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    19. Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex. Mol Cell. 2016 10 06; 64(1):12-23. Davey NE, Morgan DO. PMID: 27716480; PMCID: PMC5098475.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    20. Cell division: Mitotic regulation comes into focus. Nature. 2016 08 25; 536(7617):407-8. Morgan DO. PMID: 27509855.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development. Dev Cell. 2016 Feb 08; 36(3):344-52. Galli M, Morgan DO. PMID: 26859356; PMCID: PMC4748171.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    22. Quantitative framework for ordered degradation of APC/C substrates. BMC Biol. 2015 Nov 16; 13:96. Lu D, Girard JR, Li W, Mizrak A, Morgan DO. PMID: 26573515; PMCID: PMC4647693.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    23. An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition. J Biol Chem. 2015 Oct 02; 290(40):24614-25. Girard JR, Tenthorey JL, Morgan DO. PMID: 26306044; PMCID: PMC4591839.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J Cell Biol. 2014 Oct 13; 207(1):23-39. Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO. PMID: 25287299; PMCID: PMC4195823.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    25. Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis. J Cell Sci. 2014 Nov 15; 127(Pt 22):4974-83. Eshleman HD, Morgan DO. PMID: 25236599; PMCID: PMC4231310.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    26. Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr Biol. 2014 Jul 07; 24(13):1556-62. Van Voorhis VA, Morgan DO. PMID: 24930963; PMCID: PMC4090254.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    27. Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J Cell Sci. 2014 Mar 01; 127(Pt 5):1128-37. Naylor SG, Morgan DO. PMID: 24413167; PMCID: PMC3937778.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. The D box meets its match. Mol Cell. 2013 Jun 06; 50(5):609-10. Morgan DO. PMID: 23746347; PMCID: PMC3702177.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat Struct Mol Biol. 2013 Feb; 20(2):194-201. Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO. PMID: 23314252; PMCID: PMC3565030.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    30. The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol Cell. 2012 Sep 28; 47(6):921-32. Foster SA, Morgan DO. PMID: 22940250; PMCID: PMC3462283.
      View in: PubMed   Mentions: 76     Fields:    Translation:Cells
    31. Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation. Dev Cell. 2012 Jul 17; 23(1):124-36. Yaakov G, Thorn K, Morgan DO. PMID: 22814605; PMCID: PMC3413326.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    32. Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes. J Biol Chem. 2011 Dec 30; 286(52):45186-96. Schaefer JB, Morgan DO. PMID: 22072716; PMCID: PMC3247991.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    33. Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature. 2011 Oct 12; 480(7375):128-31. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M. PMID: 21993622; PMCID: PMC3228899.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    34. Dynamics of Cdk1 substrate specificity during the cell cycle. Mol Cell. 2011 Jun 10; 42(5):610-23. Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M. PMID: 21658602; PMCID: PMC3115021.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    35. Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol Cell. 2011 May 06; 42(3):378-89. Lyons NA, Morgan DO. PMID: 21549314; PMCID: PMC3095509.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    36. Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol Cell. 2010 Aug 27; 39(4):548-59. Rodrigo-Brenni MC, Foster SA, Morgan DO. PMID: 20797627; PMCID: PMC2929935.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    37. The hidden rhythms of the dividing cell. Cell. 2010 Apr 16; 141(2):224-6. Morgan DO. PMID: 20403319.
      View in: PubMed   Mentions: 5     Fields:    
    38. Cyclin-dependent kinases: a family portrait. Nat Cell Biol. 2009 Nov; 11(11):1275-6. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. PMID: 19884882; PMCID: PMC2914104.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    39. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science. 2009 Sep 25; 325(5948):1682-6. Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO. PMID: 19779198; PMCID: PMC2813701.
      View in: PubMed   Mentions: 558     Fields:    Translation:AnimalsCells
    40. Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol Cell. 2009 Apr 10; 34(1):68-80. Matyskiela ME, Morgan DO. PMID: 19362536; PMCID: PMC2754851.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    41. Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J Biol. 2009; 8(10):92. Matyskiela ME, Rodrigo-Brenni MC, Morgan DO. PMID: 19874575; PMCID: PMC2790831.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    42. The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell. 2009 Feb; 20(4):1201-12. Tully GH, Nishihama R, Pringle JR, Morgan DO. PMID: 19109423; PMCID: PMC2642741.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    43. SnapShot: Cell-cycle regulators II. Cell. 2008 Nov 28; 135(5):974-974.e1. Morgan DO. PMID: 19041757.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    44. SnapShot: cell-cycle regulators I. Cell. 2008 Nov 14; 135(4):764-764.e1. Morgan DO. PMID: 19013283.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    45. Cyclin-specific control of ribosomal DNA segregation. Mol Cell Biol. 2008 Sep; 28(17):5328-36. Sullivan M, Holt L, Morgan DO. PMID: 18591250; PMCID: PMC2519743.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    46. Positive feedback sharpens the anaphase switch. Nature. 2008 Jul 17; 454(7202):353-7. Holt LJ, Krutchinsky AN, Morgan DO. PMID: 18552837; PMCID: PMC2636747.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    47. Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol Cell. 2008 May 23; 30(4):437-46. Enquist-Newman M, Sullivan M, Morgan DO. PMID: 18498748; PMCID: PMC2494983.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    48. Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1442-7. Blethrow JD, Glavy JS, Morgan DO, Shokat KM. PMID: 18234856; PMCID: PMC2234163.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCells
    49. Finishing mitosis, one step at a time. Nat Rev Mol Cell Biol. 2007 Nov; 8(11):894-903. Sullivan M, Morgan DO. PMID: 17912263.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimalsCells
    50. Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol Biol Cell. 2007 Dec; 18(12):5139-53. Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR. PMID: 17942599; PMCID: PMC2096582.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    51. The role of self-association in Fin1 function on the mitotic spindle. J Biol Chem. 2007 Nov 02; 282(44):32138-43. Woodbury EL, Morgan DO. PMID: 17804403.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    52. Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell. 2007 Jul 13; 130(1):127-39. Rodrigo-Brenni MC, Morgan DO. PMID: 17632060.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    53. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7. Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. PMID: 17589519.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    54. A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I. J Biol Chem. 2007 Jul 06; 282(27):19710-5. Sullivan M, Morgan DO. PMID: 17493939.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    55. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell. 2007 Mar 09; 25(5):689-702. Holt LJ, Hutti JE, Cantley LC, Morgan DO. PMID: 17349956; PMCID: PMC1939968.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    56. Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol. 2007 Jan; 9(1):106-12. Woodbury EL, Morgan DO. PMID: 17173039.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    57. An architectural map of the anaphase-promoting complex. Genes Dev. 2006 Feb 15; 20(4):449-60. Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP. PMID: 16481473; PMCID: PMC1369047.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    58. Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature. 2005 Mar 03; 434(7029):104-8. Loog M, Morgan DO. PMID: 15744308.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
    59. The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr Biol. 2005 Jan 11; 15(1):11-8. Carroll CW, Enquist-Newman M, Morgan DO. PMID: 15649358.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    60. Enzymology of the anaphase-promoting complex. Methods Enzymol. 2005; 398:219-30. Carroll CW, Morgan DO. PMID: 16275331.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    61. Targets of the cyclin-dependent kinase Cdk1. Nature. 2003 Oct 23; 425(6960):859-64. Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO. PMID: 14574415.
      View in: PubMed   Mentions: 476     Fields:    Translation:AnimalsCells
    62. The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol. 2002 Nov; 4(11):880-7. Carroll CW, Morgan DO. PMID: 12402045.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    63. Oscillation sensation. Nature. 2002 Aug 01; 418(6897):495-6. Morgan DO, Roberts JM. PMID: 12152065.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    64. Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr Opin Cell Biol. 2000 Dec; 12(6):658-65. Takizawa CG, Morgan DO. PMID: 11063929.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    65. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21; 407(6802):395-401. Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM. PMID: 11014197.
      View in: PubMed   Mentions: 572     Fields:    Translation:HumansAnimalsCells
    66. Cdc14 activates cdc15 to promote mitotic exit in budding yeast. Curr Biol. 2000 May 18; 10(10):615-8. Jaspersen SL, Morgan DO. PMID: 10837230.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    67. Cdc37 promotes the stability of protein kinases Cdc28 and Cak1. Mol Cell Biol. 2000 Feb; 20(3):749-54. Farrell A, Morgan DO. PMID: 10629030; PMCID: PMC85190.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    68. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. Genes Dev. 1999 Aug 01; 13(15):1936-49. Tinker-Kulberg RL, Morgan DO. PMID: 10444592; PMCID: PMC316917.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    69. Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7938-43. Takizawa CG, Weis K, Morgan DO. PMID: 10393926; PMCID: PMC22166.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    70. Regulation of the APC and the exit from mitosis. Nat Cell Biol. 1999 Jun; 1(2):E47-53. Morgan DO. PMID: 10559897.
      View in: PubMed   Mentions: 108     Fields:    Translation:Animals
    71. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr Biol. 1999 Mar 11; 9(5):227-36. Jaspersen SL, Charles JF, Morgan DO. PMID: 10074450.
      View in: PubMed   Mentions: 168     Fields:    Translation:Cells
    72. Cak1 is required for Kin28 phosphorylation and activation in vivo. Mol Cell Biol. 1998 Nov; 18(11):6365-73. Espinoza FH, Farrell A, Nourse JL, Chamberlin HM, Gileadi O, Morgan DO. PMID: 9774652; PMCID: PMC109222.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    73. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 1998 Oct; 9(10):2803-17. Jaspersen SL, Charles JF, Tinker-Kulberg RL, Morgan DO. PMID: 9763445; PMCID: PMC25555.
      View in: PubMed   Mentions: 139     Fields:    Translation:Animals
    74. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24; 281(5376):533-8. Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG. PMID: 9677190.
      View in: PubMed   Mentions:
    75. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol. 1998 May 18; 141(4):875-85. Jin P, Hardy S, Morgan DO. PMID: 9585407; PMCID: PMC2132764.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    76. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr Biol. 1998 Apr 23; 8(9):497-507. Charles JF, Jaspersen SL, Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. PMID: 9560342.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    77. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Biol. 1997; 13:261-91. Morgan DO. PMID: 9442875.
      View in: PubMed   Mentions: 533     Fields:    Translation:HumansAnimalsCells
    78. The dynamics of cyclin dependent kinase structure. Curr Opin Cell Biol. 1996 Dec; 8(6):767-72. Morgan DO. PMID: 8939669.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    79. Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Nat Struct Biol. 1996 Oct; 3(10):849-55. Kim KK, Chamberlin HM, Morgan DO, Kim SH. PMID: 8836101.
      View in: PubMed   Mentions:
    80. A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science. 1996 Sep 20; 273(5282):1714-7. Espinoza FH, Farrell A, Erdjument-Bromage H, Tempst P, Morgan DO. PMID: 8781234.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    81. CAK in TFIIH: crucial connection or confounding coincidence? Biochim Biophys Acta. 1996 Aug 08; 1288(1):O7-10. Fisher RP, Morgan DO. PMID: 8764843.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    82. Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J Cell Biol. 1996 Aug; 134(4):963-70. Jin P, Gu Y, Morgan DO. PMID: 8769420; PMCID: PMC2120957.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    83. Under arrest at atomic resolution. Nature. 1996 Jul 25; 382(6589):295-6. Morgan DO. PMID: 8684452.
      View in: PubMed   Mentions:
    84. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell. 1995 Oct 06; 83(1):47-57. Fisher RP, Jin P, Chamberlin HM, Morgan DO. PMID: 7553872.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    85. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 1995 Jun 15; 9(12):1505-17. Kaplan KB, Swedlow JR, Morgan DO, Varmus HE. PMID: 7541382.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    86. Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4651-5. Gerber MR, Farrell A, Deshaies RJ, Herskowitz I, Morgan DO. PMID: 7753858; PMCID: PMC42002.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    87. Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature. 1995 Mar 16; 374(6519):283-7. Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D. PMID: 7533895.
      View in: PubMed   Mentions:
    88. Principles of CDK regulation. Nature. 1995 Mar 09; 374(6518):131-4. Morgan DO. PMID: 7877684.
      View in: PubMed   Mentions: 693     Fields:    Translation:AnimalsCells
    89. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol. 1995 Jan; 15(1):345-50. Desai D, Wessling HC, Fisher RP, Morgan DO. PMID: 7799941; PMCID: PMC231966.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    90. Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science. 1994 Nov 25; 266(5189):1388-91. Espinoza FH, Ogas J, Herskowitz I, Morgan DO. PMID: 7973730.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    91. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J. 1994 Oct 17; 13(20):4745-56. Kaplan KB, Bibbins KB, Swedlow JR, Arnaud M, Morgan DO, Varmus HE. PMID: 7525268; PMCID: PMC395413.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    92. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell. 1994 Aug 26; 78(4):713-24. Fisher RP, Morgan DO. PMID: 8069918.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    93. Protein kinase regulation: insights from crystal structure analysis. Curr Opin Cell Biol. 1994 Apr; 6(2):239-46. Morgan DO, De Bondt HL. PMID: 7517688.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    94. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature. 1993 Dec 16; 366(6456):707-10. Gu Y, Turck CW, Morgan DO. PMID: 8259216.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    95. Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae. Mol Cell Biol. 1993 Sep; 13(9):5290-300. Murphy SM, Bergman M, Morgan DO. PMID: 7689149; PMCID: PMC360223.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    96. Crystal structure of cyclin-dependent kinase 2. Nature. 1993 Jun 17; 363(6430):595-602. De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH. PMID: 8510751.
      View in: PubMed   Mentions:
    97. Purification and crystallization of human cyclin-dependent kinase 2. J Mol Biol. 1993 Apr 20; 230(4):1317-9. Rosenblatt J, De Bondt H, Jancarik J, Morgan DO, Kim SH. PMID: 8487311.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    98. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 1992 Nov; 11(11):3995-4005. Gu Y, Rosenblatt J, Morgan DO. PMID: 1396589; PMCID: PMC556910.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansCells
    99. Association of p60c-src with endosomal membranes in mammalian fibroblasts. J Cell Biol. 1992 Jul; 118(2):321-33. Kaplan KB, Swedlow JR, Varmus HE, Morgan DO. PMID: 1378446; PMCID: PMC2290043.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    100. Activation of human cyclin-dependent kinases in vitro. Mol Biol Cell. 1992 May; 3(5):571-82. Desai D, Gu Y, Morgan DO. PMID: 1535244; PMCID: PMC275609.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    101. Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2824-8. Rosenblatt J, Gu Y, Morgan DO. PMID: 1532660; PMCID: PMC48755.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    102. Cell cycle control in normal and neoplastic cells. Curr Opin Genet Dev. 1992 Feb; 2(1):33-7. Morgan DO. PMID: 1385997.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    103. Production of p60c-src by baculovirus expression and immunoaffinity purification. Methods Enzymol. 1991; 200:645-60. Morgan DO, Kaplan JM, Bishop JM, Varmus HE. PMID: 1720191.
      View in: PubMed   Mentions:
    104. Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase. Cell. 1989 Jun 02; 57(5):775-86. Morgan DO, Kaplan JM, Bishop JM, Varmus HE. PMID: 2470513.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    105. Insulin-like growth factor II receptor as a multifunctional binding protein. Nature. 1987 Sep 24-30; 329(6137):301-7. Morgan DO, Edman JC, Standring DN, Fried VA, Smith MC, Roth RA, Rutter WJ. PMID: 2957598.
      View in: PubMed   Mentions:
    106. Antibody-induced down-regulation of a mutated insulin receptor lacking an intact cytoplasmic domain. Biochemistry. 1987 Jun 02; 26(11):2959-63. Morgan DO, Ellis L, Rutter WJ, Roth RA. PMID: 3607002.
      View in: PubMed   Mentions:
    107. Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin. Proc Natl Acad Sci U S A. 1987 Jan; 84(1):41-5. Morgan DO, Roth RA. PMID: 3540958; PMCID: PMC304137.
      View in: PubMed   Mentions:
    108. Linking functional domains of the human insulin receptor with the bacterial aspartate receptor. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8137-41. Ellis L, Morgan DO, Koshland DE, Clauser E, Moe GR, Bollag G, Roth RA, Rutter WJ. PMID: 3022282; PMCID: PMC386882.
      View in: PubMed   Mentions:
    109. Purification and characterization of the receptor for insulin-like growth factor I. Biochemistry. 1986 Sep 23; 25(19):5560-4. Morgan DO, Jarnagin K, Roth RA. PMID: 2946318.
      View in: PubMed   Mentions:
    110. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell. 1986 Jun 06; 45(5):721-32. Ellis L, Clauser E, Morgan DO, Edery M, Roth RA, Rutter WJ. PMID: 3518947.
      View in: PubMed   Mentions:
    111. Mapping surface structures of the human insulin receptor with monoclonal antibodies: localization of main immunogenic regions to the receptor kinase domain. Biochemistry. 1986 Mar 25; 25(6):1364-71. Morgan DO, Roth RA. PMID: 2421765.
      View in: PubMed   Mentions:
    112. Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):328-32. Morgan DO, Ho L, Korn LJ, Roth RA. PMID: 3455769; PMCID: PMC322851.
      View in: PubMed   Mentions:
    113. Plate binding assay for monoclonal anti-receptor antibodies. Endocrinology. 1985 Mar; 116(3):1224-6. Morgan DO, Roth RA. PMID: 3971907.
      View in: PubMed   Mentions:
    114. A proposed role for prostaglandins in the modulation of the relaxation response to urotensin I in isolated rat arteries. Prostaglandins. 1981 Dec; 22(6):873-92. Gerritsen ME, Morgan DO, Parks TP, Printz MP, Lederis KP. PMID: 6801731.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    115. Oxytocin action: lack of correlation between receptor number and tissue responsiveness. J Supramol Struct. 1980; 14(2):129-38. Goren HJ, Geonzon RM, Hollenberg MD, Lederis K, Morgan DO. PMID: 6262573.
      View in: PubMed   Mentions:
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