Patricia Leake, PhD
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Title(s) | Professor Emeritus, Otolaryngology |
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School | School of Medicine |
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Address | 533 Parnassus Avenue San Francisco CA 94117
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Phone | 415-476-5958 |
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vCard | Download vCard |
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Biography University of California, San Francisco | Ph.D. | 1976 | Graduate Division (Anatomy) |
Overview Patricia A Leake, PhD, is a Professor and Director of the Saul and Ida Epstein Laboratory for Auditory Physiology and Genetics in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. She received her MA and PhD in neuroanatomy from the University of California, San Francisco, and this was followed by a postdoctoral fellowship in the Coleman Laboratory in the Department of OHNS at UCSF.
Dr. Leake’s main research interest is in the development and safe clinical application of multichannel cochlear prostheses, with a particular focus on the plasticity elicited in the developing auditory system following early onset profound hearing loss and cochlear implantation. Research in the Saul and Ida Epstein Laboratory for Hearing Research explores the functional encoding of electrical stimulation delivered to the auditory nerve by a cochlear implant, examining the responses of ensembles of neurons within the auditory midbrain or inferior colliculus (IC).
Dr. Leake’s primary areas of research interest have been in exploring the effects of early deafness, electrical stimulation from a cochlear implant and exogenous neurotrophins on the morphology of the cochlea and cochlear nucleus, on the development of auditory nerve projections to the brainstem, and on functional alterations in the central auditory system. Most recently, this research has focused on the potential use of AAV-mediated neurotrophin gene therapy to improve auditory nerve survival after early deafness and thereby to optimize the function of a cochlear implant.
Specialty: Research in Auditory neuroscience, cochlear implants, plasticity, gene therapy
Expertise:
Professional Interests: Cochlear morphology, cochlear prostheses, auditory nerve, auditory system development, auditory system plasticity, central auditory neural pathways, cochlear spiral ganglion, cochlear nucleus, development of topographic maps, electrical stimulation, neonatal deafness, neurotrophin/neurotrophic agents, temporal processing, tonotopic organization, adeno-associated viral vector therapies
Education and Training: • MA: University of California, San Francisco - Neuroanatomy • PhD: University of California, San Francisco - Neuroanatomy • Postdoctoral Fellowship: University of California, San Francisco
Awards and Honors: • 1966 Baldwin Wallace College, Berea, OH - George J. Record Scholar • 1970 Baldwin Wallace College, Berea, OH - Laurels Honor Society for Women • 1970 University of California, San Francisco Department of Anatomy - Regents Scholar • 1998 European Symposium on Paediatric Cochlear Implants - Keynote Lecturer, Netherlands • 1998 Purdue University - Distinguished Lecturer in Neuroscience • 2004 7th European Symposium on Paediatric Cochlear Implantation, Geneva - Keynote Lecture • 2002 University of California, San Francisco Department of Otolaryngology – Head and Neck Surgery - Georgia G. Sullivan Endowed Chair in Hearing Research • 2002 Helmholtz Instituut, University of Utrecht, The Netherlands - Helmholtz Lecturer
Research ORNG Applications Bibliographic
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Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness. Hear Res. 2020 Sep 01; 394:107955.
Leake PA, Akil O, Lang H. PMID: 32331858.
View in: PubMed Mentions: Fields:
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AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF. J Assoc Res Otolaryngol. 2019 08; 20(4):341-361.
Leake PA, Rebscher SJ, Dore' C, Akil O. PMID: 31222416.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss. Hum Gene Ther. 2019 01; 30(1):88-105.
Akil O, Blits B, Lustig LR, Leake PA. PMID: 30183384.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Effects of brain-derived neurotrophic factor (BDNF) on the cochlear nucleus in cats deafened as neonates. Hear Res. 2016 12; 342:134-143.
PMID: 27773647.
View in: PubMed Mentions: Fields: Translation: Animals
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Passive stimulation and behavioral training differentially transform temporal processing in the inferior colliculus and primary auditory cortex. J Neurophysiol. 2017 01 01; 117(1):47-64.
PMID: 27733594.
View in: PubMed Mentions: 7 Fields: Translation: Animals
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Effects of brain-derived neurotrophic factor (BDNF) and electrical stimulation on survival and function of cochlear spiral ganglion neurons in deafened, developing cats. J Assoc Res Otolaryngol. 2013 Apr; 14(2):187-211.
PMID: 23392612.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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Monopolar intracochlear pulse trains selectively activate the inferior colliculus. J Assoc Res Otolaryngol. 2012 Oct; 13(5):655-72.
PMID: 22722899.
View in: PubMed Mentions: 1 Fields: Translation: Animals
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Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats. J Comp Neurol. 2011 Jun 01; 519(8):1526-45.
PMID: 21452221.
View in: PubMed Mentions: 31 Fields: Translation: HumansAnimalsCells
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Consensus panel on a cochlear coordinate system applicable in histologic, physiologic, and radiologic studies of the human cochlea. Otol Neurotol. 2010 Jul; 31(5):722-30.
Verbist BM, Skinner MW, Cohen LT, Leake PA, James C, Boëx C, Holden TA, Finley CC, Roland PS, Roland JT, Haller M, Patrick JF, Jolly CN, Faltys MA, Briaire JJ, Frijns JH. PMID: 20147866.
View in: PubMed Mentions: 31 Fields: Translation: Humans
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Topography of auditory nerve projections to the cochlear nucleus in cats after neonatal deafness and electrical stimulation by a cochlear implant. J Assoc Res Otolaryngol. 2008 Sep; 9(3):349-72.
Leake PA, Hradek GT, Bonham BH, Snyder RL. PMID: 18574634.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Factors influencing neurotrophic effects of electrical stimulation in the deafened developing auditory system. Hear Res. 2008 Aug; 242(1-2):86-99.
Leake PA, Stakhovskaya O, Hradek GT, Hetherington AM. PMID: 18573324.
View in: PubMed Mentions: 20 Fields: Translation: Animals
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Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus in cats. Hear Res. 2008 Sep; 243(1-2):69-77.
Stakhovskaya O, Hradek GT, Snyder RL, Leake PA. PMID: 18590947.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimals
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Considerations for design of future cochlear implant electrode arrays: electrode array stiffness, size, and depth of insertion. J Rehabil Res Dev. 2008; 45(5):731-47.
Rebscher SJ, Hetherington A, Bonham B, Wardrop P, Whinney D, Leake PA. PMID: 18816423.
View in: PubMed Mentions: 32 Fields: Translation: Humans
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Spatial selectivity to intracochlear electrical stimulation in the inferior colliculus is degraded after long-term deafness in cats. J Neurophysiol. 2007 Nov; 98(5):2588-603.
Vollmer M, Beitel RE, Snyder RL, Leake PA. PMID: 17855592.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
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Spontaneous discharge patterns in cochlear spiral ganglion cells before the onset of hearing in cats. J Neurophysiol. 2007 Oct; 98(4):1898-908.
Jones TA, Leake PA, Snyder RL, Stakhovskaya O, Bonham B. PMID: 17686914.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Design and fabrication of multichannel cochlear implants for animal research. J Neurosci Methods. 2007 Oct 15; 166(1):1-12.
Rebscher SJ, Hetherington AM, Snyder RL, Leake PA, Bonham BH. PMID: 17727956.
View in: PubMed Mentions: 16 Fields: Translation: HumansAnimals
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Neurotrophic effects of GM1 ganglioside and electrical stimulation on cochlear spiral ganglion neurons in cats deafened as neonates. J Comp Neurol. 2007 Apr 20; 501(6):837-53.
Leake PA, Hradek GT, Vollmer M, Rebscher SJ. PMID: 17311311.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Frequency map for the human cochlear spiral ganglion: implications for cochlear implants. J Assoc Res Otolaryngol. 2007 Jun; 8(2):220-33.
Stakhovskaya O, Sridhar D, Bonham BH, Leake PA. PMID: 17318276.
View in: PubMed Mentions: 75 Fields: Translation: Humans
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Hermaphroditism: cytogenetics, gonadal pathology and gender assignment: a case report. West Indian Med J. 2006 Dec; 55(6):430-3.
Duncan ND, Gabay L, Williams E, Dundas SE, Plummer N, Leake PA. PMID: 17691240.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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A frequency-position function for the human cochlear spiral ganglion. Audiol Neurootol. 2006; 11 Suppl 1:16-20.
Sridhar D, Stakhovskaya O, Leake PA. PMID: 17063006.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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Neonatal deafness results in degraded topographic specificity of auditory nerve projections to the cochlear nucleus in cats. J Comp Neurol. 2006 Jul 01; 497(1):13-31.
Leake PA, Hradek GT, Chair L, Snyder RL. PMID: 16680765.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. I: Comparison of Nucleus banded and Nucleus Contour electrodes. Hear Res. 2005 May; 203(1-2):54-67.
Wardrop P, Whinney D, Rebscher SJ, Roland JT, Luxford W, Leake PA. PMID: 15855030.
View in: PubMed Mentions: 37 Fields: Translation: Humans
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A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. II: Comparison of Spiral Clarion and HiFocus II electrodes. Hear Res. 2005 May; 203(1-2):68-79.
Wardrop P, Whinney D, Rebscher SJ, Luxford W, Leake P. PMID: 15855031.
View in: PubMed Mentions: 26 Fields: Translation: Humans
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Degradation of temporal resolution in the auditory midbrain after prolonged deafness is reversed by electrical stimulation of the cochlea. J Neurophysiol. 2005 Jun; 93(6):3339-55.
Vollmer M, Leake PA, Beitel RE, Rebscher SJ, Snyder RL. PMID: 15659529.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
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Postnatal refinement of auditory nerve projections to the cochlear nucleus in cats. J Comp Neurol. 2002 Jun 17; 448(1):6-27.
Leake PA, Snyder RL, Hradek GT. PMID: 12012373.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
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The effects of chronic intracochlear electrical stimulation on inferior colliculus spatial representation in adult deafened cats. Hear Res. 2002 Feb; 164(1-2):82-96.
Moore CM, Vollmer M, Leake PA, Snyder RL, Rebscher SJ. PMID: 11950528.
View in: PubMed Mentions: 21 Fields: Translation: Animals
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Year | Publications |
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2002 | 2 | 2005 | 3 | 2006 | 3 | 2007 | 5 | 2008 | 4 | 2010 | 1 | 2011 | 1 | 2012 | 1 | 2013 | 1 | 2016 | 2 | 2018 | 1 | 2019 | 1 | 2020 | 1 |
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