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Patricia Leake, PhD

Title(s)Professor Emeritus, Otolaryngology
SchoolSchool of Medicine
Phone415-476-5958
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1976 Graduate Division (Anatomy)

    Collapse Overview 
    Collapse Overview
    Patricia A Leake, PhD, is a Professor and Director of the Saul and Ida Epstein Laboratory for Auditory Physiology and Genetics in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. She received her MA and PhD in neuroanatomy from the University of California, San Francisco, and this was followed by a postdoctoral fellowship in the Coleman Laboratory in the Department of OHNS at UCSF.

    Dr. Leake’s main research interest is in the development and safe clinical application of multichannel cochlear prostheses, with a particular focus on the plasticity elicited in the developing auditory system following early onset profound hearing loss and cochlear implantation. Research in the Saul and Ida Epstein Laboratory for Hearing Research explores the functional encoding of electrical stimulation delivered to the auditory nerve by a cochlear implant, examining the responses of ensembles of neurons within the auditory midbrain or inferior colliculus (IC).

    Dr. Leake’s primary areas of research interest have been in exploring the effects of early deafness, electrical stimulation from a cochlear implant and exogenous neurotrophins on the morphology of the cochlea and cochlear nucleus, on the development of auditory nerve projections to the brainstem, and on functional alterations in the central auditory system. Most recently, this research has focused on the potential use of AAV-mediated neurotrophin gene therapy to improve auditory nerve survival after early deafness and thereby to optimize the function of a cochlear implant.

    Specialty:
    Research in Auditory neuroscience, cochlear implants, plasticity, gene therapy

    Expertise:

    Professional Interests:
    Cochlear morphology, cochlear prostheses, auditory nerve, auditory system development, auditory system plasticity, central auditory neural pathways, cochlear spiral ganglion, cochlear nucleus, development of topographic maps, electrical stimulation, neonatal deafness, neurotrophin/neurotrophic agents, temporal processing, tonotopic organization, adeno-associated viral vector therapies

    Education and Training:
    • MA: University of California, San Francisco - Neuroanatomy
    • PhD: University of California, San Francisco - Neuroanatomy
    • Postdoctoral Fellowship: University of California, San Francisco

    Awards and Honors:
    • 1966 Baldwin Wallace College, Berea, OH - George J. Record Scholar
    • 1970 Baldwin Wallace College, Berea, OH - Laurels Honor Society for Women
    • 1970 University of California, San Francisco Department of Anatomy - Regents Scholar
    • 1998 European Symposium on Paediatric Cochlear Implants - Keynote Lecturer, Netherlands
    • 1998 Purdue University - Distinguished Lecturer in Neuroscience
    • 2004 7th European Symposium on Paediatric Cochlear Implantation, Geneva - Keynote Lecture
    • 2002 University of California, San Francisco Department of Otolaryngology – Head and Neck Surgery - Georgia G. Sullivan Endowed Chair in Hearing Research
    • 2002 Helmholtz Instituut, University of Utrecht, The Netherlands - Helmholtz Lecturer

    Collapse Research 
    Collapse Research Activities and Funding
    AVV-Mediated Neurotrophin Expression in the Deafened Cochlea
    NIH/NIDCD R01DC013067Dec 1, 2013 - Nov 30, 2016
    Role: Principal Investigator
    TAS::75 0890::TAS-REQUISITION B
    NIH 263200700054C-7-0-1Sep 30, 2007 - Sep 29, 2012
    Role: Principal Investigator
    EFFECTS OF PATTERNED ELEC. STIM ON DEAFENED AUDITORY SYS
    NIH/NIDCD N01DC002108Sep 30, 2000 - Sep 29, 2003
    Role: Principal Investigator
    PROTECT EFFECTS PATTERNED STIM DEAF AUDITORY SYSTEM
    NIH/NIDCD N01DC042143Sep 30, 1994 - Sep 29, 1997
    Role: Principal Investigator
    PATTERNED ELECTRICAL STIMULATION/DEAFENED
    NIH/NIDCD N01DC012400Jun 30, 1991 - Sep 30, 1994
    Role: Principal Investigator
    Development &Connections of Cochlear Spiral Ganglion
    NIH/NIDCD R01DC000160Jul 1, 1980 - Nov 30, 2009
    Role: Principal Investigator
    MORPHOLOGY AND CONNECTIONS OF THE SPIRAL GANGLION
    NIH/NINDS R01NS016361Jul 1, 1980 - Jun 30, 1988
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Leake PA, Akil O, Lang H. Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness. Hear Res. 2020 Apr 05; 107955. PMID: 32331858.
      View in: PubMed
    2. Leake PA, Rebscher SJ, Dore' C, Akil O. AAV-Mediated Neurotrophin Gene Therapy Promotes Improved Survival of Cochlear Spiral Ganglion Neurons in Neonatally Deafened Cats: Comparison of AAV2-hBDNF and AAV5-hGDNF. J Assoc Res Otolaryngol. 2019 08; 20(4):341-361. PMID: 31222416.
      View in: PubMed
    3. Akil O, Blits B, Lustig LR, Leake PA. Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss. Hum Gene Ther. 2019 01; 30(1):88-105. PMID: 30183384.
      View in: PubMed
    4. Kandathil CK, Stakhovskaya O, Leake PA. Effects of brain-derived neurotrophic factor (BDNF) on the cochlear nucleus in cats deafened as neonates. Hear Res. 2016 12; 342:134-143. PMID: 27773647.
      View in: PubMed
    5. Vollmer M, Beitel RE, Schreiner CE, Leake PA. Passive stimulation and behavioral training differentially transform temporal processing in the inferior colliculus and primary auditory cortex. J Neurophysiol. 2017 01 01; 117(1):47-64. PMID: 27733594.
      View in: PubMed
    6. Leake PA, Stakhovskaya O, Hetherington A, Rebscher SJ, Bonham B. Effects of brain-derived neurotrophic factor (BDNF) and electrical stimulation on survival and function of cochlear spiral ganglion neurons in deafened, developing cats. J Assoc Res Otolaryngol. 2013 Apr; 14(2):187-211. PMID: 23392612.
      View in: PubMed
    7. Schoenecker MC, Bonham BH, Stakhovskaya OA, Snyder RL, Leake PA. Monopolar intracochlear pulse trains selectively activate the inferior colliculus. J Assoc Res Otolaryngol. 2012 Oct; 13(5):655-72. PMID: 22722899.
      View in: PubMed
    8. Leake PA, Hradek GT, Hetherington AM, Stakhovskaya O. Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats. J Comp Neurol. 2011 Jun 01; 519(8):1526-45. PMID: 21452221.
      View in: PubMed
    9. Verbist BM, Skinner MW, Cohen LT, Leake PA, James C, Boëx C, Holden TA, Finley CC, Roland PS, Roland JT, Haller M, Patrick JF, Jolly CN, Faltys MA, Briaire JJ, Frijns JH. Consensus panel on a cochlear coordinate system applicable in histologic, physiologic, and radiologic studies of the human cochlea. Otol Neurotol. 2010 Jul; 31(5):722-30. PMID: 20147866.
      View in: PubMed
    10. Leake PA, Hradek GT, Bonham BH, Snyder RL. Topography of auditory nerve projections to the cochlear nucleus in cats after neonatal deafness and electrical stimulation by a cochlear implant. J Assoc Res Otolaryngol. 2008 Sep; 9(3):349-72. PMID: 18574634.
      View in: PubMed
    11. Leake PA, Stakhovskaya O, Hradek GT, Hetherington AM. Factors influencing neurotrophic effects of electrical stimulation in the deafened developing auditory system. Hear Res. 2008 Aug; 242(1-2):86-99. PMID: 18573324.
      View in: PubMed
    12. Stakhovskaya O, Hradek GT, Snyder RL, Leake PA. Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus in cats. Hear Res. 2008 Sep; 243(1-2):69-77. PMID: 18590947.
      View in: PubMed
    13. Rebscher SJ, Hetherington A, Bonham B, Wardrop P, Whinney D, Leake PA. Considerations for design of future cochlear implant electrode arrays: electrode array stiffness, size, and depth of insertion. J Rehabil Res Dev. 2008; 45(5):731-47. PMID: 18816423.
      View in: PubMed
    14. Vollmer M, Beitel RE, Snyder RL, Leake PA. Spatial selectivity to intracochlear electrical stimulation in the inferior colliculus is degraded after long-term deafness in cats. J Neurophysiol. 2007 Nov; 98(5):2588-603. PMID: 17855592.
      View in: PubMed
    15. Jones TA, Leake PA, Snyder RL, Stakhovskaya O, Bonham B. Spontaneous discharge patterns in cochlear spiral ganglion cells before the onset of hearing in cats. J Neurophysiol. 2007 Oct; 98(4):1898-908. PMID: 17686914.
      View in: PubMed
    16. Rebscher SJ, Hetherington AM, Snyder RL, Leake PA, Bonham BH. Design and fabrication of multichannel cochlear implants for animal research. J Neurosci Methods. 2007 Oct 15; 166(1):1-12. PMID: 17727956.
      View in: PubMed
    17. Leake PA, Hradek GT, Vollmer M, Rebscher SJ. Neurotrophic effects of GM1 ganglioside and electrical stimulation on cochlear spiral ganglion neurons in cats deafened as neonates. J Comp Neurol. 2007 Apr 20; 501(6):837-53. PMID: 17311311.
      View in: PubMed
    18. Stakhovskaya O, Sridhar D, Bonham BH, Leake PA. Frequency map for the human cochlear spiral ganglion: implications for cochlear implants. J Assoc Res Otolaryngol. 2007 Jun; 8(2):220-33. PMID: 17318276.
      View in: PubMed
    19. Duncan ND, Gabay L, Williams E, Dundas SE, Plummer N, Leake PA. Hermaphroditism: cytogenetics, gonadal pathology and gender assignment: a case report. West Indian Med J. 2006 Dec; 55(6):430-3. PMID: 17691240.
      View in: PubMed
    20. Sridhar D, Stakhovskaya O, Leake PA. A frequency-position function for the human cochlear spiral ganglion. Audiol Neurootol. 2006; 11 Suppl 1:16-20. PMID: 17063006.
      View in: PubMed
    21. Leake PA, Hradek GT, Chair L, Snyder RL. Neonatal deafness results in degraded topographic specificity of auditory nerve projections to the cochlear nucleus in cats. J Comp Neurol. 2006 Jul 01; 497(1):13-31. PMID: 16680765.
      View in: PubMed
    22. Wardrop P, Whinney D, Rebscher SJ, Roland JT, Luxford W, Leake PA. A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. I: Comparison of Nucleus banded and Nucleus Contour electrodes. Hear Res. 2005 May; 203(1-2):54-67. PMID: 15855030.
      View in: PubMed
    23. Wardrop P, Whinney D, Rebscher SJ, Luxford W, Leake P. A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. II: Comparison of Spiral Clarion and HiFocus II electrodes. Hear Res. 2005 May; 203(1-2):68-79. PMID: 15855031.
      View in: PubMed
    24. Vollmer M, Leake PA, Beitel RE, Rebscher SJ, Snyder RL. Degradation of temporal resolution in the auditory midbrain after prolonged deafness is reversed by electrical stimulation of the cochlea. J Neurophysiol. 2005 Jun; 93(6):3339-55. PMID: 15659529.
      View in: PubMed
    25. Leake PA, Snyder RL, Hradek GT. Postnatal refinement of auditory nerve projections to the cochlear nucleus in cats. J Comp Neurol. 2002 Jun 17; 448(1):6-27. PMID: 12012373.
      View in: PubMed
    26. Moore CM, Vollmer M, Leake PA, Snyder RL, Rebscher SJ. The effects of chronic intracochlear electrical stimulation on inferior colliculus spatial representation in adult deafened cats. Hear Res. 2002 Feb; 164(1-2):82-96. PMID: 11950528.
      View in: PubMed