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Patricia Leake, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentOtolaryngology
Address533 Parnassus Avenue
San Francisco CA 94117
Phone415-476-5958
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPh.D.1976 Graduate Division (Anatomy)

    Collapse Overview 
    Collapse Overview
    Patricia A Leake, PhD, is a Professor and Director of the Saul and Ida Epstein Laboratory for Auditory Physiology and Genetics in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. She received her MA and PhD in neuroanatomy from the University of California, San Francisco, and this was followed by a postdoctoral fellowship in the Coleman Laboratory in the Department of OHNS at UCSF.

    Dr. Leake’s main research interest is in the development and safe clinical application of multichannel cochlear prostheses, with a particular focus on the plasticity elicited in the developing auditory system following early onset profound hearing loss and cochlear implantation. Research in the Saul and Ida Epstein Laboratory for Hearing Research explores the functional encoding of electrical stimulation delivered to the auditory nerve by a cochlear implant, examining the responses of ensembles of neurons within the auditory midbrain or inferior colliculus (IC).

    Dr. Leake’s primary areas of research interest have been in exploring the effects of early deafness, electrical stimulation from a cochlear implant and exogenous neurotrophins on the morphology of the cochlea and cochlear nucleus, on the development of auditory nerve projections to the brainstem, and on functional alterations in the central auditory system. Most recently, this research has focused on the potential use of AAV-mediated neurotrophin gene therapy to improve auditory nerve survival after early deafness and thereby to optimize the function of a cochlear implant.

    Specialty:
    Research in Auditory neuroscience, cochlear implants, plasticity, gene therapy

    Expertise:

    Professional Interests:
    Cochlear morphology, cochlear prostheses, auditory nerve, auditory system development, auditory system plasticity, central auditory neural pathways, cochlear spiral ganglion, cochlear nucleus, development of topographic maps, electrical stimulation, neonatal deafness, neurotrophin/neurotrophic agents, temporal processing, tonotopic organization, adeno-associated viral vector therapies

    Education and Training:
    • MA: University of California, San Francisco - Neuroanatomy
    • PhD: University of California, San Francisco - Neuroanatomy
    • Postdoctoral Fellowship: University of California, San Francisco

    Awards and Honors:
    • 1966 Baldwin Wallace College, Berea, OH - George J. Record Scholar
    • 1970 Baldwin Wallace College, Berea, OH - Laurels Honor Society for Women
    • 1970 University of California, San Francisco Department of Anatomy - Regents Scholar
    • 1998 European Symposium on Paediatric Cochlear Implants - Keynote Lecturer, Netherlands
    • 1998 Purdue University - Distinguished Lecturer in Neuroscience
    • 2004 7th European Symposium on Paediatric Cochlear Implantation, Geneva - Keynote Lecture
    • 2002 University of California, San Francisco Department of Otolaryngology – Head and Neck Surgery - Georgia G. Sullivan Endowed Chair in Hearing Research
    • 2002 Helmholtz Instituut, University of Utrecht, The Netherlands - Helmholtz Lecturer


    Collapse Research 
    Collapse Research Activities and Funding
    AVV-Mediated Neurotrophin Expression in the Deafened Cochlea
    NIH/NIDCD R01DC013067Dec 1, 2013 - Nov 30, 2016
    Role: Principal Investigator
    TAS::75 0890::TAS-REQUISITION B
    NIH 263200700054C-7-0-1Sep 30, 2007 - Sep 29, 2012
    Role: Principal Investigator
    EFFECTS OF PATTERNED ELEC. STIM ON DEAFENED AUDITORY SYS
    NIH/NIDCD N01DC002108Sep 30, 2000 - Sep 29, 2003
    Role: Principal Investigator
    PROTECT EFFECTS PATTERNED STIM DEAF AUDITORY SYSTEM
    NIH/NIDCD N01DC042143Sep 30, 1994 - Sep 29, 1997
    Role: Principal Investigator
    PATTERNED ELECTRICAL STIMULATION/DEAFENED
    NIH/NIDCD N01DC012400Jun 30, 1991 - Sep 30, 1994
    Role: Principal Investigator
    Development &Connections of Cochlear Spiral Ganglion
    NIH/NIDCD R01DC000160Jul 1, 1980 - Nov 30, 2009
    Role: Principal Investigator
    MORPHOLOGY AND CONNECTIONS OF THE SPIRAL GANGLION
    NIH/NINDS R01NS016361Jul 1, 1980 - Jun 30, 1988
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kandathil CK, Stakhovskaya O, Leake P. Effects of brain-derived neurotrophic factor (BDNF) on the cochlear nucleus in cats deafened as neonates. Hear Res. 2016 12; 342:134-143. PMID: 27773647.
      View in: PubMed
    2. Vollmer M, Beitel RE, Schreiner CE, Leake P. Passive stimulation and behavioral training differentially transform temporal processing in the inferior colliculus and primary auditory cortex. J Neurophysiol. 2017 Jan 01; 117(1):47-64. PMID: 27733594.
      View in: PubMed
    3. Leake P, Stakhovskaya O, Hetherington A, Rebscher SJ, Bonham B. Effects of brain-derived neurotrophic factor (BDNF) and electrical stimulation on survival and function of cochlear spiral ganglion neurons in deafened, developing cats. J Assoc Res Otolaryngol. 2013 Apr; 14(2):187-211. PMID: 23392612; PMCID: PMC3660916.
    4. Schoenecker MC, Bonham BH, Stakhovskaya OA, Snyder RL, Leake P. Monopolar intracochlear pulse trains selectively activate the inferior colliculus. J Assoc Res Otolaryngol. 2012 Oct; 13(5):655-72. PMID: 22722899; PMCID: PMC3441950.
    5. Leake P, Hradek GT, Hetherington AM, Stakhovskaya O. Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats. J Comp Neurol. 2011 Jun 01; 519(8):1526-45. PMID: 21452221; PMCID: PMC3079794.
    6. Verbist BM, Skinner MW, Cohen LT, Leake P, James C, Boëx C, Holden TA, Finley CC, Roland PS, Roland JT, Haller M, Patrick JF, Jolly CN, Faltys MA, Briaire JJ, Frijns JH. Consensus panel on a cochlear coordinate system applicable in histologic, physiologic, and radiologic studies of the human cochlea. Otol Neurotol. 2010 Jul; 31(5):722-30. PMID: 20147866.
      View in: PubMed
    7. Leake P, Hradek GT, Bonham BH, Snyder RL. Topography of auditory nerve projections to the cochlear nucleus in cats after neonatal deafness and electrical stimulation by a cochlear implant. J Assoc Res Otolaryngol. 2008 Sep; 9(3):349-72. PMID: 18574634; PMCID: PMC2516742.
    8. Leake P, Stakhovskaya O, Hradek GT, Hetherington AM. Factors influencing neurotrophic effects of electrical stimulation in the deafened developing auditory system. Hear Res. 2008 Aug; 242(1-2):86-99. PMID: 18573324; PMCID: PMC2516744.
    9. Stakhovskaya O, Hradek GT, Snyder RL, Leake P. Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus in cats. Hear Res. 2008 Sep; 243(1-2):69-77. PMID: 18590947; PMCID: PMC2575007.
    10. Rebscher SJ, Hetherington A, Bonham B, Wardrop P, Whinney D, Leake P. Considerations for design of future cochlear implant electrode arrays: electrode array stiffness, size, and depth of insertion. J Rehabil Res Dev. 2008; 45(5):731-47. PMID: 18816423.
      View in: PubMed
    11. Vollmer M, Beitel RE, Snyder RL, Leake P. Spatial selectivity to intracochlear electrical stimulation in the inferior colliculus is degraded after long-term deafness in cats. J Neurophysiol. 2007 Nov; 98(5):2588-603. PMID: 17855592.
      View in: PubMed
    12. Jones TA, Leake P, Snyder RL, Stakhovskaya O, Bonham B. Spontaneous discharge patterns in cochlear spiral ganglion cells before the onset of hearing in cats. J Neurophysiol. 2007 Oct; 98(4):1898-908. PMID: 17686914; PMCID: PMC2234389.
    13. Rebscher SJ, Hetherington AM, Snyder RL, Leake P, Bonham BH. Design and fabrication of multichannel cochlear implants for animal research. J Neurosci Methods. 2007 Oct 15; 166(1):1-12. PMID: 17727956.
      View in: PubMed
    14. Leake P, Hradek GT, Vollmer M, Rebscher SJ. Neurotrophic effects of GM1 ganglioside and electrical stimulation on cochlear spiral ganglion neurons in cats deafened as neonates. J Comp Neurol. 2007 Apr 20; 501(6):837-53. PMID: 17311311.
      View in: PubMed
    15. Stakhovskaya O, Sridhar D, Bonham BH, Leake P. Frequency map for the human cochlear spiral ganglion: implications for cochlear implants. J Assoc Res Otolaryngol. 2007 Jun; 8(2):220-33. PMID: 17318276.
      View in: PubMed
    16. Duncan ND, Gabay L, Williams E, Dundas SE, Plummer N, Leake P. Hermaphroditism: cytogenetics, gonadal pathology and gender assignment: a case report. West Indian Med J. 2006 Dec; 55(6):430-3. PMID: 17691240.
      View in: PubMed
    17. Sridhar D, Stakhovskaya O, Leake P. A frequency-position function for the human cochlear spiral ganglion. Audiol Neurootol. 2006; 11 Suppl 1:16-20. PMID: 17063006.
      View in: PubMed
    18. Leake P, Hradek GT, Chair L, Snyder RL. Neonatal deafness results in degraded topographic specificity of auditory nerve projections to the cochlear nucleus in cats. J Comp Neurol. 2006 Jul 01; 497(1):13-31. PMID: 16680765.
      View in: PubMed
    19. Wardrop P, Whinney D, Rebscher SJ, Roland JT, Luxford W, Leake P. A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. I: Comparison of Nucleus banded and Nucleus Contour electrodes. Hear Res. 2005 May; 203(1-2):54-67. PMID: 15855030.
      View in: PubMed
    20. Wardrop P, Whinney D, Rebscher SJ, Luxford W, Leake P. A temporal bone study of insertion trauma and intracochlear position of cochlear implant electrodes. II: Comparison of Spiral Clarion and HiFocus II electrodes. Hear Res. 2005 May; 203(1-2):68-79. PMID: 15855031.
      View in: PubMed
    21. Vollmer M, Leake P, Beitel RE, Rebscher SJ, Snyder RL. Degradation of temporal resolution in the auditory midbrain after prolonged deafness is reversed by electrical stimulation of the cochlea. J Neurophysiol. 2005 Jun; 93(6):3339-55. PMID: 15659529.
      View in: PubMed
    22. Leake P, Snyder RL, Hradek GT. Postnatal refinement of auditory nerve projections to the cochlear nucleus in cats. J Comp Neurol. 2002 Jun 17; 448(1):6-27. PMID: 12012373; PMCID: PMC2386504.
    23. Moore CM, Vollmer M, Leake P, Snyder RL, Rebscher SJ. The effects of chronic intracochlear electrical stimulation on inferior colliculus spatial representation in adult deafened cats. Hear Res. 2002 Feb; 164(1-2):82-96. PMID: 11950528.
      View in: PubMed
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