Dylan Chan, MD, PhD

Title(s)Associate Professor, Otolaryngology
SchoolSchool of Medicine
Address550 16th. Street
San Francisco CA 94158
Phone415-353-2870
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    Dylan K. Chan, MD, PhD, is an Associate Professor in Residence and he is the Director of the Children’s Communication Center (CCC) in the Department of Otolaryngology – Head and Neck Surgery (ONHS) at the University of California, San Francisco. He received his PhD in Sensory Neuroscience from the Rockefeller University in New York, and he obtained his medical degree from Weill Medical College of Cornell University, New York. Dr. Chan completed his ONHS residency from Stanford University School of Medicine, California, followed by a Pediatric Otolaryngology fellowship at the Seattle Children’s Hospital, Washington.

    In 2014, Dr. Chan established the UCSF Children’s Communication Center, which is devoted to delivering multidisciplinary care for families of deaf and hard of hearing children, performing community outreach and education, and conducting clinical and translational research projects. By addressing existing shortfalls in care delivery and developing novel treatments, he hopes to significantly impact hearing health in children. His laboratory is interested in investigating the pathophysiology and genetics of hearing loss associated with mutations in Connexin 26, the most commonly affected gene in congenital hearing loss, and the development of gene therapy for hearing restoration.

    Dr. Chan is a scientific reviewer for various scientific journals, frequent invited speaker at local and national conferences, and has published over 15 articles

    Specialty:
    Cochlear Implant Surgery and Pediatric Otolaryngology

    Expertise:
    Pediatric hearing loss, cochlear implantation, chronic ear surgery, and ear canal reconstruction; obstructive sleep apnea and sleep endoscopy; velopharyngeal insufficiency

    Professional Interests:
    Multidisciplinary management, diagnostic testing, genetics, and treatment of deaf and hard of hearing children; health disparities in treatment and outcomes of pediatric hearing loss; pathophysiology and genetics of Connexin-26-associated hearing loss; pediatric communication disorders.

    Education and Training:
    • PhD: The Rockefeller University, New York, NY – Sensory Neuroscience
    • Medical School: Weill Medical College of Cornell University, New York, NY
    • Residency: Stanford University School of Medicine, CA – Otolaryngology-Head and Neck Surgery
    • Fellowship: Seattle Children’s Hospital, WA – Pediatric Otolaryngology

    Awards and Honors:
    • 2014 ANS/AAO-HNSF - Herbert Silverstein Award
    • 2014 American Hearing Research Foundation Research Grant
    • 2015 American Society for Pediatric Otolaryngology Career Development Award

    Collapse Research 
    Collapse Research Activities and Funding
    The role of TMTC4, endoplasmic reticulum Ca2+ flux, and the unfolded protein response in noise-induced hearing loss
    NIH R01DC018583Apr 1, 2020 - Mar 31, 2025
    Role: Principal Investigator
    Pathophysiology of hearing loss associated with Connexin 26 dysfunction
    NIH R03DC015082Dec 1, 2015 - Nov 30, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Congenital aural atresia and first branchial cleft anomalies: Cholesteatoma and surgical management. Laryngoscope Investig Otolaryngol. 2022 Jun; 7(3):863-869. Liao EN, Chan DK. PMID: 35734058; PMCID: PMC9195010.
      View in: PubMed   Mentions:
    2. Outcomes of an Early Childhood Hearing Screening Program in a Low-Income Setting. JAMA Otolaryngol Head Neck Surg. 2022 04 01; 148(4):326-332. Brodie KD, David AP, Kriss H, Chan DK. PMID: 35175312; PMCID: PMC8855310.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    3. Disparities in Speech and Language Delay Among Children With Aural Atresia. Ear Hear. 2022 Sep-Oct 01; 43(5):1574-1581. Florentine MM, Le Clec'h S, Upton SM, Scarpelli C, Carr JP, Chan DK. PMID: 35319519.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Early surgical and audiologic outcomes of active, transcutaneous, osseointegrated bone-conduction hearing device (Osia 2® system) placement. Int J Pediatr Otorhinolaryngol. 2022 May; 156:111114. Florentine MM, Virbalas J, Chan DK. PMID: 35314374.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Racial and ethnic disparities in diagnostic efficacy of comprehensive genetic testing for sensorineural hearing loss. Hum Genet. 2022 Apr; 141(3-4):495-504. Florentine MM, Rouse SL, Stephans J, Conrad D, Czechowicz J, Matthews IR, Meyer AK, Nadaraja GS, Parikh R, Virbalas J, Weinstein JE, Chan DK. PMID: 34515852; PMCID: PMC9035005.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Access Challenge Index: A Novel Disparity Measure Predictive of Language Outcomes in Children Who Are Deaf/Hard of Hearing. Otolaryngol Head Neck Surg. 2022 07; 167(1):170-177. Florentine MM, Strohl MP, Benvenuti CS, Eiseman M, Ho M, Meyer AK, Scarpelli C, Chan DK. PMID: 34488501.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Racial and ethnic disparities in genetic testing for hearing loss: a systematic review and synthesis. Hum Genet. 2022 Apr; 141(3-4):485-494. Rouse SL, Florentine MM, Taketa E, Chan DK. PMID: 34494120; PMCID: PMC9035011.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Tracking Home Language Production and Environment in Children Who Are Deaf or Hard of Hearing. Otolaryngol Head Neck Surg. 2022 01; 166(1):171-178. Sola AM, Brodie KD, Stephans J, Scarpelli C, Chan DK. PMID: 34032520.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Prevalence of SARS-CoV-2 Infection in Children Without Symptoms of Coronavirus Disease 2019. JAMA Pediatr. 2021 02 01; 175(2):198-201. Sola AM, David AP, Rosbe KW, Baba A, Ramirez-Avila L, Chan DK. PMID: 32840605; PMCID: PMC7851725.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    10. Validation of a Hearing-Related Quality-of-Life Questionnaire for Parents and Deaf or Hard-of-Hearing Infants and Toddlers. Otolaryngol Head Neck Surg. 2021 08; 165(2):360-369. Sola AM, Vukkadala N, Giridhar S, Stephans J, Allen IE, Chan DK. PMID: 33317400.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Endoscope-assisted open rhinoplasty approach for removal of nasal dermoid with intracranial extension. Otolaryngology Case Reports. 2020 Nov 1; 17:100211. David DA, House HA, Chan CD. .
      View in: Publisher Site   Mentions:
    12. Genetic Testing Leading to Early Identification of Childhood Ocular Manifestations of Usher Syndrome. Laryngoscope. 2021 06; 131(6):E2053-E2059. Brodie KD, Moore AT, Slavotinek AM, Meyer AK, Nadaraja GS, Conrad DE, Weinstein JE, Chan DK. PMID: 33111992.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Integrated stress response inhibition provides sex-dependent protection against noise-induced cochlear synaptopathy. Sci Rep. 2020 10 22; 10(1):18063. Rouse SL, Matthews IR, Li J, Sherr EH, Chan DK. PMID: 33093490; PMCID: PMC7582887.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. Management of Congenital Cytomegalovirus-Related Hearing Loss. Current Otorhinolaryngology Reports. 2020 Sep 1; 8(3):243-249. David DA, Chan CD. .
      View in: Publisher Site   Mentions:
    15. Cryoprobe retrieval of an airway foreign body: A case report and literature review. Int J Pediatr Otorhinolaryngol. 2019 Oct; 125:79-81. David AP, Xu MJ, Rosbe KW, Meyer AK, Gesthalter YB, Chan DK. PMID: 31271971.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Awake bedside nasal endoscopy for primary management of neonatal dacryocystoceles with intranasal cysts. Int J Pediatr Otorhinolaryngol. 2019 Aug; 123:93-96. Zhao NW, Chan DK. PMID: 31085463.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Seeking equilibrium: The experiences of parents of infants and toddlers who are deaf/hard-of-hearing. J Pediatr Rehabil Med. 2019; 12(1):11-20. Vukkadala N, Giridhar SBP, Okumura MJ, Chan DK. PMID: 30883371.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Implications of dried blood spot testing for congenital CMV on management of children with hearing loss: A preliminary report. Int J Pediatr Otorhinolaryngol. 2019 Apr; 119:10-14. Lee ER, Chan DK. PMID: 30660013.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Use of otoacoustic emissions to improve outcomes and reduce disparities in a community preschool hearing screening program. PLoS One. 2018; 13(12):e0208050. Cedars E, Kriss H, Lazar AA, Chan C, Chan DK. PMID: 30532159; PMCID: PMC6287830.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    20. Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss. J Clin Invest. 2018 11 01; 128(11):5150-5162. Li J, Akil O, Rouse SL, McLaughlin CW, Matthews IR, Lustig LR, Chan DK, Sherr EH. PMID: 30188326; PMCID: PMC6205388.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. Unilateral Hearing Loss in Youth: Development of Candidate Items for a Condition-Specific Validated Instrument. Otolaryngol Head Neck Surg. 2018 Aug 28; 194599818797092. Purcell PL, Edwards TC, Wisneski M, Chan DK, Ou H, Horn DL, Skirko JR, Sie KCY. PMID: 30149769.
      View in: PubMed   Mentions:    Fields:    
    22. Linguistic and behavioral performance of bilingual children with hearing loss. Int J Pediatr Otorhinolaryngol. 2018 Sep; 112:34-38. Vukkadala N, Perez D, Cabala S, Kapur C, Chan DK. PMID: 30055736.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Case 45: Masses in the Oral Cavity. . 2018 Jun 1; 311-318. Koltai KP, Lan LW, Chan CD, Hoff HS. .
      View in: Publisher Site   Mentions:
    24. Endoscopic percutaneous suture lateralization for neonatal bilateral vocal fold immobility. Int J Pediatr Otorhinolaryngol. 2018 May; 108:120-124. Montague GL, Bly RA, Nadaraja GS, Conrad DE, Parikh SR, Chan DK. PMID: 29605340.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Diagnosis and Treatment of Congenital Sensorineural Hearing Loss. Curr Otorhinolaryngol Rep. 2017 Dec; 5(4):251-258. Chari DA, Chan DK. PMID: 29761033; PMCID: PMC5947965.
      View in: PubMed   Mentions: 6  
    26. Impact of Primary Language and Insurance on Pediatric Hearing Health Care in a Multidisciplinary Clinic. Otolaryngol Head Neck Surg. 2017 10; 157(4):722-730. Su BM, Park JS, Chan DK. PMID: 28895463.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Prevalence of Hearing Loss in US Children and Adolescents: Findings From NHANES 1988-2010. JAMA Otolaryngol Head Neck Surg. 2017 09 01; 143(9):920-927. Su BM, Chan DK. PMID: 28750123; PMCID: PMC5710291.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    28. Tongue surgeries for pediatric obstructive sleep apnea: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2017 Aug; 274(8):2981-2990. Camacho M, Noller MW, Zaghi S, Reckley LK, Fernandez-Salvador C, Ho E, Dunn B, Chan D. PMID: 28378061.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. Characteristics of Extremely Low Gestational Age Newborns Undergoing Tracheotomy: A Secondary Analysis of the Trial of Late Surfactant Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2017 01 01; 143(1):13-19. Wai KC, Keller RL, Lusk LA, Ballard RA, Chan DK, Trial of Late Surfactant (TOLSURF) Study Group. PMID: 27583380.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. Response to Letter to the Editor. Int J Pediatr Otorhinolaryngol. 2017 02; 93:173. Cedars E, Chan D, Meyer A, Rosbe K. PMID: 28081872.
      View in: PubMed   Mentions:    Fields:    
    31. Clinically small tonsils are typically not obstructive in children during drug-induced sleep endoscopy. Laryngoscope. 2017 08; 127(8):1943-1949. Miller C, Purcell PL, Dahl JP, Johnson K, Horn DL, Chen ML, Chan DK, Parikh SR. PMID: 28008627; PMCID: PMC5892447.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Sound-Induced Intracellular Ca2+ Dynamics in the Adult Hearing Cochlea. PLoS One. 2016; 11(12):e0167850. Chan DK, Rouse SL. PMID: 27959894; PMCID: PMC5154517.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Conversion of traditional osseointegrated bone-anchored hearing aids to the Baha® attract in four pediatric patients. Int J Pediatr Otorhinolaryngol. 2016 Dec; 91:37-42. Cedars E, Chan D, Lao A, Hardies L, Meyer A, Rosbe K. PMID: 27863639.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Sinonasal Quality of Life in Children With Cystic Fibrosis. JAMA Otolaryngol Head Neck Surg. 2016 08 01; 142(8):743-9. Chan DK, McNamara S, Park JS, Vajda J, Gibson RL, Parikh SR. PMID: 27228505.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. Occult central venous stenosis leading to airway obstruction after subtotal parathyroidectomy. Ear Nose Throat J. 2016 Jul; 95(7):E11-3. Meiklejohn DA, Chan DK, Lalakea ML. PMID: 27434479.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. The current state of pediatric drug-induced sleep endoscopy. Laryngoscope. 2017 01; 127(1):266-272. Friedman NR, Parikh SR, Ishman SL, Ruiz AG, El-Hakim H, Ulualp SO, Wootten CT, Koltai PJ, Chan DK. PMID: 27311407.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    37. Airway Obstruction during Drug-Induced Sleep Endoscopy Correlates with Apnea-Hypopnea Index and Oxygen Nadir in Children. Otolaryngol Head Neck Surg. 2016 10; 155(4):676-80. Dahl JP, Miller C, Purcell PL, Zopf DA, Johnson K, Horn DL, Chen ML, Chan DK, Parikh SR. PMID: 27301902.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Supraglottoplasty for laryngomalacia with obstructive sleep apnea: A systematic review and meta-analysis. Laryngoscope. 2016 05; 126(5):1246-55. Camacho M, Dunn B, Torre C, Sasaki J, Gonzales R, Liu SY, Chan DK, Certal V, Cable BB. PMID: 26691675.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    39. Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations. Int J Pediatr Otorhinolaryngol. 2015 Dec; 79(12):2466-9. Alemi AS, Rosbe KW, Chan DK, Meyer AK. PMID: 26549380.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Progressive Hearing Loss and Head Trauma in Enlarged Vestibular Aqueduct: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2015 Oct; 153(4):512-7. Alemi AS, Chan DK. PMID: 26204902.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    41. Surgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane. J Vis Exp. 2015 Mar 16; (97). Akil O, Rouse SL, Chan DK, Lustig LR. PMID: 25867531; PMCID: PMC4401361.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    42. A new scoring system for upper airway pediatric sleep endoscopy. JAMA Otolaryngol Head Neck Surg. 2014 Jul; 140(7):595-602. Chan DK, Liming BJ, Horn DL, Parikh SR. PMID: 24810174.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    43. Perioperative ketorolac increases post-tonsillectomy hemorrhage in adults but not children. Laryngoscope. 2014 Aug; 124(8):1789-93. Chan DK, Parikh SR. PMID: 24338331.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    44. Upper aerodigestive magnetic foreign bodies in children. Laryngoscope. 2014 Jun; 124(6):1481-5. Brown JC, Baik FM, Ou HC, Otjen JP, Parish HG, Chan DK. PMID: 24391087.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    45. GJB2-associated hearing loss: systematic review of worldwide prevalence, genotype, and auditory phenotype. Laryngoscope. 2014 Feb; 124(2):E34-53. Chan DK, Chang KW. PMID: 23900770.
      View in: PubMed   Mentions: 112     Fields:    Translation:Humans
    46. Effect of obesity and medical comorbidities on outcomes after adjunct surgery for obstructive sleep apnea in cases of adenotonsillectomy failure. Arch Otolaryngol Head Neck Surg. 2012 Oct; 138(10):891-6. Chan DK, Jan TA, Koltai PJ. PMID: 23069817.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    47. Supraglottoplasty for occult laryngomalacia to improve obstructive sleep apnea syndrome. Arch Otolaryngol Head Neck Surg. 2012 Jan; 138(1):50-4. Chan DK, Truong MT, Koltai PJ. PMID: 22249629.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    48. Masses in the Oral Cavity. NeoReviews. 2011 Sep 1; 12(9):e545-e549. Koltai KP, Lan LW, Chan CD, Hoff HS. .
      View in: Publisher Site   Mentions:
    49. Diagnostic yield in the workup of congenital sensorineural hearing loss is dependent on patient ethnicity. Otol Neurotol. 2011 Jan; 32(1):81-7. Chan DK, Schrijver I, Chang KW. PMID: 21042228.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    50. Connexin-26-associated deafness: phenotypic variability and progression of hearing loss. Genet Med. 2010 Mar; 12(3):174-81. Chan DK, Schrijver I, Chang KW. PMID: 20154630.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    51. Protection against cisplatin-induced ototoxicity by adeno-associated virus-mediated delivery of the X-linked inhibitor of apoptosis protein is not dependent on caspase inhibition. Otol Neurotol. 2007 Apr; 28(3):417-25. Chan DK, Lieberman DM, Musatov S, Goldfein JA, Selesnick SH, Kaplitt MG. PMID: 17211286.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    52. Mutation of the atrophin2 gene in the zebrafish disrupts signaling by fibroblast growth factor during development of the inner ear. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9069-74. Asai Y, Chan DK, Starr CJ, Kappler JA, Kollmar R, Hudspeth AJ. PMID: 16754885; PMCID: PMC1474007.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    53. AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity. Otol Neurotol. 2006 Jun; 27(4):484-90. Cooper LB, Chan DK, Roediger FC, Shaffer BR, Fraser JF, Musatov S, Selesnick SH, Kaplitt MG. PMID: 16791039.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    54. Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro. Nat Neurosci. 2005 Feb; 8(2):149-55. Chan DK, Hudspeth AJ. PMID: 15643426; PMCID: PMC2151387.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
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