Roarke Kamber, PhD

Title(s)Assistant Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1349A
San Francisco CA 94143
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    Stanford University, Stanford, CAPostdoctoral Fellowship2023Genetics
    Harvard University, Cambridge, MAPhD2016Biological and Biomedical Sciences
    Stanford University, Stanford, CABS2009Biology

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    My research interests center on understanding how macrophages detect and eliminate disease-causing cells, including cancer cells, and determining why this homeostatic process fails in aging and disease. To this end, my research encompasses questions in immunology and cancer biology, and leverages a wide range of experimental approaches including genome-wide CRISPR screens, live-cell imaging, biochemical reconstitution, and animal models. We aim to systematically map the inter-cellular signaling axes between macrophages and their target cells that govern phagocytosis, with a particular focus on defining the roles of uncharacterized genes and metabolites in this process. These discovery-based efforts will allow us to understand how macrophages make the all-or-none decision to destroy another cell, to characterize pathological failure modes, and to engineer innate immune cells with enhanced therapeutic properties. The ultimate goal of my research program is to uncover fundamental biological insights that enable next-generation immunotherapies for currently untreatable diseases.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking. bioRxiv. 2024 Jan 03. Donnelly J, Kamber RA, Wisnovsky S, Roberts DS, Peltan EL, Bassik MC, Bertozzi CR. PMID: 38260508; PMCID: PMC10802331.
      View in: PubMed   Mentions:
    2. Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras. Science. 2023 10 20; 382(6668):eadf6249. Ahn G, Riley NM, Kamber RA, Wisnovsky S, Moncayo von Hase S, Bassik MC, Banik SM, Bertozzi CR. PMID: 37856615; PMCID: PMC10766146.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    3. Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat Chem. 2023 Nov; 15(11):1616-1625. Chen Y, Craven GB, Kamber RA, Cuesta A, Zhersh S, Moroz YS, Bassik MC, Taunton J. PMID: 37460812.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast. Elife. 2022 04 11; 11. Yu H, Kamber RA, Denic V. PMID: 35404228; PMCID: PMC9000956.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis. Nature. 2021 09; 597(7877):549-554. Kamber RA, Nishiga Y, Morton B, Banuelos AM, Barkal AA, Vences-Catalán F, Gu M, Fernandez D, Seoane JA, Yao D, Liu K, Lin S, Spees K, Curtis C, Jerby-Arnon L, Weissman IL, Sage J, Bassik MC. PMID: 34497417; PMCID: PMC9419706.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    6. A genome-wide atlas of co-essential modules assigns function to uncharacterized genes. Nat Genet. 2021 05; 53(5):638-649. Wainberg M, Kamber RA, Balsubramani A, Meyers RM, Sinnott-Armstrong N, Hornburg D, Jiang L, Chan J, Jian R, Gu M, Shcherbina A, Dubreuil MM, Spees K, Meuleman W, Snyder MP, Bassik MC, Kundaje A. PMID: 33859415; PMCID: PMC8763319.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    7. CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Nature. 2020 04; 580(7801):136-141. Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC. PMID: 32238925; PMCID: PMC7368463.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    8. Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens. Nat Genet. 2018 12; 50(12):1716-1727. Haney MS, Bohlen CJ, Morgens DW, Ousey JA, Barkal AA, Tsui CK, Ego BK, Levin R, Kamber RA, Collins H, Tucker A, Li A, Vorselen D, Labitigan L, Crane E, Boyle E, Jiang L, Chan J, Rincón E, Greenleaf WJ, Li B, Snyder MP, Weissman IL, Theriot JA, Collins SR, Barres BA, Bassik MC. PMID: 30397336; PMCID: PMC6719718.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    9. The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane. Elife. 2017 09 14; 6. Weir NR, Kamber RA, Martenson JS, Denic V. PMID: 28906250; PMCID: PMC5633344.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    10. A pathway of targeted autophagy is induced by DNA damage in budding yeast. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):E1158-E1167. Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, Kamber R, Lemos B, Memisoglu G, Ang J, Mazella A, Chuartzman SG, Loewith RJ, Schuldiner M, Denic V, Klionsky DJ, Haber JE. PMID: 28154131; PMCID: PMC5320992.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    11. A molecular switch for selective autophagosome formation. Autophagy. 2015 Nov 02; 11(11):2132-2133. Kamber RA, Shoemaker CJ, Denic V. PMID: 26649944; PMCID: PMC4824575.
      View in: PubMed   Mentions: 2     Fields:    
    12. Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase. Mol Cell. 2015 Aug 06; 59(3):372-81. Kamber RA, Shoemaker CJ, Denic V. PMID: 26166702; PMCID: PMC5602610.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    13. Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics. 2009 Dec; 183(4):1385-95. Valenzano DR, Kirschner J, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, Brunet A. PMID: 19786620; PMCID: PMC2787427.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells