Alejandro Sweet-Cordero, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address1550 Fourth St, #384D
San Francisco CA 94158
Phone415-476-7781
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBA1989Biology
    Stanford UniversityBS1989Anthropology
    University of California San FranciscoMD1995Medicine

    Collapse Overview 
    Collapse Overview
    Our goal is to identify novel therapeutic approaches for cancer that target the genetic mutations and altered signaling networks that are specific to cancer cells and their microenvironment. We use functional genomics applied to mouse and human systems (genetically engineered models, patient derived xenografts) to understand the signaling pathways and transcriptional networks that regulate the outcome of specific oncogenic mutations and to identify new approaches for cancer therapy. We have two primary disease interests: lung cancer and pediatric sarcomas. Our research spans the continuum from basic discovery to preclinical target development, done in a dynamic and interactive environment that is highly collaborative.

    In our lung cancer work, we use functional genomic approaches to study how KRAS functions as an oncogene and to identify novel therapeutic opportunities. We performed one of the first mouse and human in vivo functional screens to identify WT1 loss as a synthetic vulnerability for KRAS-driven NSCLC (Vicent et al, 2010, JCI). More recently, we described a key role of oncogenic KRAS in regulation of the response to nutrient stress (Gwinn et al 2018, Cancer Cell). Through a multidisciplinary collaboration we have performed a high-throughput proteomic and genomics screen to characterize novel KRAS specific combinatorial vulnerabilities (Kelly, Kostyrko and Han, Cancer Discovery 2020). We are also interested in identifying and characterizing the role of tumor-propagating cells (also called cancer stem cells) in NSCLC. Using a combination of mouse and human systems, we identified a key role for Notch3 as a self-renewal pathway in mouse and human NSCLC (Zheng et al, 2013, Cancer Cell). We also have identified novel methods for targeting tumor-stroma interactions in lung cancer (Kim and Marquez et al, Nature Medicine, 2019). Ongoing projects are seeking to identify other KRAS specific vulnerabilities using 2D and 3D systems in both mouse and human. We are also using single-cell sequencing and other genomics approaches (ATACseq, etc) to study the role of TPCs in lung cancer.

    In our sarcoma work, we study mechanisms driving Osteosarcoma and Ewing sarcoma metastatic progression and therapy resistance using in vivo patient-derived xenograft models. These two diseases provide an interesting contrast as clinically they are similar but from a genomic stand point they are quite distinct. We identified EWSAT1 as the first lncRNA involved in the pathogenesis of Ewing sarcoma (Howarth et al, JCI, 2014) and ongoing work is focused on understanding how lncRNAs regulate the oncogenic capacity of the EWS/FLI1 fusion. In osteosarcoma, we are performing translational studies to evaluate the use of targeted therapies for this disease and to understand mechanisms of metastatic progression using PDX and GEM models. Recently, we described how genomic analysis of osteosarcoma can help identify targeted therapies for this disease (Sayles and Breese et al, Cancer Discovery 2019). Our sarcoma work is facilitated by access to a large collection of patient-derived xenograft models and primary tumor samples which have been analyzed by Whole genome sequencing and RNAseq. We are using these models to explore the genomic evolution of sarcomas and define novel therapeutics that are informed by the alterations present in individual tumors.

    We make extensive use of computational genomic approaches in our work and we have wide experience in generating and using next-generation sequencing data for gene and network discovery. We lead a multidisciplinary effort to apply next-generation sequencing (WGS/RNAseq etc.) to advance the care of relapsed and other high-risk pediatric cancer patients at UCSF/Benioff Children’s Hospitals (San Francisco and Oakland). To date, our laboratory has sequenced over 200 pediatric tumors by Whole Genome Sequencing and RNAseq. These datasets provide ample research opportunity for trainees interested in the intersection of cancer biology, functional genomics and computational biology. We have an active collaboration with the Genome Institute at the University of California Santa Cruz (D. Haussler and O. Vaske) to develop advance the care of relapsed and metastatic cancer patients using transcriptome analysis (Vaske et al JCI insight, 2019, Pfeil et al Plos Computational Biology, 2020).

    Collapse Research 
    Collapse Research Activities and Funding
    Development of novel protein-based therapeutics for lung cancer
    NIH R01CA225103Apr 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Role of long non-coding RNAs in sarcoma pathogenesis
    NIH R01CA211657Mar 13, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Using Protein Interaction Networks and Combinatorial Screens to target KRAS driven cancer
    NIH U01CA199216Sep 2, 2015 - Jul 31, 2019
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2024 May 30. Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. PMID: 38816611.
      View in: PubMed   Mentions:    Fields:    
    2. Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment. Cold Spring Harb Perspect Med. 2024 Apr 02. Young EP, Marinoff AE, Lopez-Fuentes E, Sweet-Cordero EA. PMID: 38565264.
      View in: PubMed   Mentions:    Fields:    
    3. The CLCF1-CNTFR axis drives an immunosuppressive tumor microenvironment and blockade enhances the effects of established cancer therapies. Res Sq. 2024 Mar 22. Sweet-Cordero E, Marini K, Champion E, Lee A, Young I, Leung S, Mathey-Andrews N, Jacks T, Jackson P, Cochran J. PMID: 38562778; PMCID: PMC10984090.
      View in: PubMed   Mentions:
    4. Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. Clin Cancer Res. 2024 02 16; 30(4):849-864. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. PMID: 37703185; PMCID: PMC10870121.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Pre-and post-HSCT use of TKI therapy for fusion-driven B-ALL: A case series of five pediatric, adolescent and young adult patients. Cancer Rep (Hoboken). 2023 12; 6(12):e1901. Shumock SS, Temple WC, Marinoff A, Aaronson K, Southworth E, Xirenayi S, Lee AG, Leung SG, Sweet-Cordero EA, Hermiston M, Higham C, Stieglitz E. PMID: 37933765; PMCID: PMC10728537.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma. Nat Commun. 2023 07 05; 14(1):3966. Kostyrko K, Román M, Lee AG, Simpson DR, Dinh PT, Leung SG, Marini KD, Kelly MR, Broyde J, Califano A, Jackson PK, Sweet-Cordero EA. PMID: 37407562; PMCID: PMC10322837.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Discovery of VH domains that allosterically inhibit ENPP1. Nat Chem Biol. 2024 Jan; 20(1):30-41. Solomon PE, Bracken CJ, Carozza JA, Wang H, Young EP, Wellner A, Liu CC, Sweet-Cordero EA, Li L, Wells JA. PMID: 37400538; PMCID: PMC10746542.
      View in: PubMed   Mentions: 6     Fields:    
    8. FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. Res Sq. 2023 May 29. Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A. PMID: 37398210; PMCID: PMC10312925.
      View in: PubMed   Mentions:
    9. FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer. bioRxiv. 2023 May 16. Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A. PMID: 37205599; PMCID: PMC10187251.
      View in: PubMed   Mentions:
    10. Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities. Cancer Cell. 2023 04 10; 41(4):660-677.e7. Sun CX, Daniel P, Bradshaw G, Shi H, Loi M, Chew N, Parackal S, Tsui V, Liang Y, Koptyra M, Adjumain S, Sun C, Chong WC, Fernando D, Drinkwater C, Tourchi M, Habarakada D, Sooraj D, Carvalho D, Storm PB, Baubet V, Sayles LC, Fernandez E, Nguyen T, Pörksen M, Doan A, Crombie DE, Panday M, Zhukova N, Dun MD, Ludlow LE, Day B, Stringer BW, Neeman N, Rubens JA, Raabe EH, Vinci M, Tyrrell V, Fletcher JI, Ekert PG, Dumevska B, Ziegler DS, Tsoli M, Syed Sulaiman NF, Loh AHP, Low SYY, Sweet-Cordero EA, Monje M, Resnick A, Jones C, Downie P, Williams B, Rosenbluh J, Gough D, Cain JE, Firestein R. PMID: 37001527.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities. bioRxiv. 2023 Jan 20. Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MAV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. PMID: 36711882; PMCID: PMC9882347.
      View in: PubMed   Mentions:
    12. Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies. Genome Med. 2022 10 31; 14(1):124. Fang H, Yan HHN, Bilardi RA, Flensburg C, Yang H, Barbour JA, Siu HC, Turski M, Chew E, Xu Z, Lam ST, Sharma R, Xu M, Li J, Ip HW, Cheung CYM, Huen MSY, Sweet-Cordero EA, Majewski IJ, Leung SY, Wong JWH. PMID: 36316687; PMCID: PMC9620652.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. Nat Commun. 2022 08 25; 13(1):4878. Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B. PMID: 36008377; PMCID: PMC9411569.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. A 3D Osteosarcoma Model with Bone-Mimicking Cues Reveals a Critical Role of Bone Mineral and Informs Drug Discovery. Adv Healthc Mater. 2022 09; 11(17):e2200768. González Díaz EC, Lee AG, Sayles LC, Feria C, Sweet-Cordero EA, Yang F. PMID: 35767377; PMCID: PMC10162498.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Synthetic Vulnerabilities in the KRAS Pathway. Cancers (Basel). 2022 Jun 08; 14(12). Roman M, Hwang E, Sweet-Cordero EA. PMID: 35740503; PMCID: PMC9221492.
      View in: PubMed   Mentions: 1  
    16. Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation. Mol Cell Proteomics. 2022 07; 21(7):100247. Solomon PE, Kirkemo LL, Wilson GM, Leung KK, Almond MH, Sayles LC, Sweet-Cordero EA, Rosenberg OS, Coon JJ, Wells JA. PMID: 35594991; PMCID: PMC9212846.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    17. Salud Publica Mex. 2022 Feb 25; 64(1):100-104. Van Loon K, Mohar A, Unger-Saldaña K, Potter MB, Sweet-Cordero EA, Breithaupt L, Espinosa-Tamez P, Sepúlveda-Amor J, Lajous M. PMID: 35438915.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Comparison of the Transcriptomic Signatures in Pediatric and Adult CML. Cancers (Basel). 2021 Dec 14; 13(24). Youn M, Smith SM, Lee AG, Chae HD, Spiteri E, Erdmann J, Galperin I, Jones LM, Donato M, Abidi P, Bittencourt H, Lacayo N, Dahl G, Aftandilian C, Davis KL, Matthews JA, Kornblau SM, Huang M, Sumarsono N, Redell MS, Fu CH, Chen IM, Alonzo TA, Eklund E, Gotlib J, Khatri P, Sweet-Cordero EA, Hijiya N, Sakamoto KM. PMID: 34944883; PMCID: PMC8699058.
      View in: PubMed   Mentions: 4  
    19. A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. Mol Cancer Ther. 2021 10; 20(10):2016-2025. Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA. PMID: 34353895; PMCID: PMC9307079.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. NUP98-NSD1 Driven MDS/MPN in Childhood Masquerading as JMML. J Pediatr Hematol Oncol. 2021 08 01; 43(6):e808-e811. Behnert A, Lee AG, Young EP, Breese MR, Leung SG, Behroozfard I, Maruffi M, Sweet-Cordero EA, Dvorak CC, Chu J, Stieglitz E. PMID: 32815876; PMCID: PMC7889745.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature. JCO Precis Oncol. 2020; 4. Levinson A, Lee AG, Martell HJ, Breese MR, Zaloudek C, Van Ziffle J, Laguna B, Leung SG, Chen MD, Chen LM, Pfeil J, Ladwig NR, Shah AT, Behroozfard I, Rao AA, Salama SR, Sweet-Cordero EA, Stieglitz E. PMID: 33283136; PMCID: PMC7713560.
      View in: PubMed   Mentions: 3     Fields:    
    22. An Expanded Tool Kit for Modeling the Oncogenic Functions of KRAS. Cancer Discov. 2020 11; 10(11):1626-1628. Kostyrko K, Sweet-Cordero EA. PMID: 33139339.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    23. Advances and Challenges in Pediatric and Childhood Cancers. Cancer Cell. 2020 10 12; 38(4):429-432. Hawkins C, Pfister S, Jones DTW, Shah NN, Gilbertson RJ, Sweet-Cordero EA, Dyer MA, Mossé YP, Haber M, DuBois SG. PMID: 33049203; PMCID: PMC10807849.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses. Nat Biotechnol. 2021 02; 39(2):215-224. Broyde J, Simpson DR, Murray D, Paull EO, Chu BW, Tagore S, Jones SJ, Griffin AT, Giorgi FM, Lachmann A, Jackson P, Sweet-Cordero EA, Honig B, Califano A. PMID: 32929263; PMCID: PMC7878435.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities. Cancer Discov. 2020 12; 10(12):1950-1967. Kelly MR, Kostyrko K, Han K, Mooney NA, Jeng EE, Spees K, Dinh PT, Abbott KL, Gwinn DM, Sweet-Cordero EA, Bassik MC, Jackson PK. PMID: 32727735; PMCID: PMC7710624.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    26. Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14110-14118. Kim JW, Marquez CP, Sperberg RAP, Wu J, Bae WG, Huang PS, Sweet-Cordero EA, Cochran JR. PMID: 32522868; PMCID: PMC7322068.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    27. Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures. PLoS Comput Biol. 2020 04; 16(4):e1007753. Pfeil J, Sanders LM, Anastopoulos I, Lyle AG, Weinstein AS, Xue Y, Blair A, Beale HC, Lee A, Leung SG, Dinh PT, Shah AT, Breese MR, Devine WP, Bjork I, Salama SR, Sweet-Cordero EA, Haussler D, Vaske OM. PMID: 32275708; PMCID: PMC7176284.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    28. The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas. J Clin Invest. 2020 04 01; 130(4):1879-1895. Valencia K, Erice O, Kostyrko K, Hausmann S, Guruceaga E, Tathireddy A, Flores NM, Sayles LC, Lee AG, Fragoso R, Sun TQ, Vallejo A, Roman M, Entrialgo-Cadierno R, Migueliz I, Razquin N, Fortes P, Lecanda F, Lu J, Ponz-Sarvise M, Chen CZ, Mazur PK, Sweet-Cordero EA, Vicent S. PMID: 31874105; PMCID: PMC7108928.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities. Nature. 2020 04; 580(7801):136-141. Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC. PMID: 32238925; PMCID: PMC7368463.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    30. Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies. Adv Exp Med Biol. 2020; 1258:1-19. Schott C, Shah AT, Sweet-Cordero EA. PMID: 32767231.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    31. Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma. Nat Med. 2019 11; 25(11):1783-1795. Kim JW, Marquez CP, Kostyrko K, Koehne AL, Marini K, Simpson DR, Lee AG, Leung SG, Sayles LC, Shrager J, Ferrer I, Paz-Ares L, Gephart MH, Vicent S, Cochran JR, Sweet-Cordero EA. PMID: 31700175; PMCID: PMC7087454.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    32. Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor. Cold Spring Harb Mol Case Stud. 2019 10; 5(5). Sanders LM, Rangaswami A, Bjork I, Lam DL, Beale HC, Kephart ET, Durbin A, Learned K, Currie R, Lyle AG, Pfeil J, Shah AT, Lee AG, Leung SG, Behroozfard IH, Breese MR, Peralez J, Hazard FK, Lacayo N, Spunt SL, Haussler D, Salama SR, Sweet-Cordero EA, Vaske OM. PMID: 31645344; PMCID: PMC6824255.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    33. Ewing sarcoma in a child with neurofibromatosis type 1. Cold Spring Harb Mol Case Stud. 2019 10; 5(5). Fernandez KS, Turski ML, Shah AT, Bastian BC, Horvai A, Hardee S, Sweet-Cordero EA. PMID: 31645347; PMCID: PMC6824249.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer. JAMA Netw Open. 2019 10 02; 2(10):e1913968. Vaske OM, Bjork I, Salama SR, Beale H, Tayi Shah A, Sanders L, Pfeil J, Lam DL, Learned K, Durbin A, Kephart ET, Currie R, Newton Y, Swatloski T, McColl D, Vivian J, Zhu J, Lee AG, Leung SG, Spillinger A, Liu HY, Liang WS, Byron SA, Berens ME, Resnick AC, Lacayo N, Spunt SL, Rangaswami A, Huynh V, Torno L, Plant A, Kirov I, Zabokrtsky KB, Rassekh SR, Deyell RJ, Laskin J, Marra MA, Sender LS, Mueller S, Sweet-Cordero EA, Goldstein TC, Haussler D. PMID: 31651965; PMCID: PMC6822083.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    35. Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing. Leukemia. 2020 02; 34(2):662-666. Chao AK, Meyer JA, Lee AG, Hecht A, Tarver T, Van Ziffle J, Koegel AK, Golden C, Braun BS, Sweet-Cordero EA, Smith CC, Dvorak CC, Loh ML, Stieglitz E. PMID: 31511612; PMCID: PMC6995757.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    36. Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. Cancer. 2019 10 15; 125(20):3514-3525. Roberts RD, Lizardo MM, Reed DR, Hingorani P, Glover J, Allen-Rhoades W, Fan T, Khanna C, Sweet-Cordero EA, Cash T, Bishop MW, Hegde M, Sertil AR, Koelsche C, Mirabello L, Malkin D, Sorensen PH, Meltzer PS, Janeway KA, Gorlick R, Crompton BD. PMID: 31355930; PMCID: PMC6948723.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    37. Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules. Front Oncol. 2019; 9:288. Ren Y, Huang S, Dai C, Xie D, Zheng L, Xie H, Zheng H, She Y, Zhou F, Wang Y, Li P, Fei K, Jiang G, Zhang Y, Su B, Sweet-Cordero EA, Tran NL, Yang Y, Patel JN, Rolfo C, Rocco G, Cardona AF, Tuzi A, Suter MB, Yang P, Xu W, Chen C. PMID: 31058088; PMCID: PMC6482264.
      View in: PubMed   Mentions: 14  
    38. The genomic landscape of pediatric cancers: Implications for diagnosis and treatment. Science. 2019 03 15; 363(6432):1170-1175. Sweet-Cordero EA, Biegel JA. PMID: 30872516; PMCID: PMC7757338.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    39. Genome-Informed Targeted Therapy for Osteosarcoma. Cancer Discov. 2019 01; 9(1):46-63. Sayles LC, Breese MR, Koehne AL, Leung SG, Lee AG, Liu HY, Spillinger A, Shah AT, Tanasa B, Straessler K, Hazard FK, Spunt SL, Marina N, Kim GE, Cho SJ, Avedian RS, Mohler DG, Kim MO, DuBois SG, Hawkins DS, Sweet-Cordero EA. PMID: 30266815; PMCID: PMC7134333.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimals
    40. Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. Sci Transl Med. 2018 07 25; 10(451). Marini KD, Croucher DR, McCloy RA, Vaghjiani V, Gonzalez-Rajal A, Hastings JF, Chin V, Szczepny A, Kostyrko K, Marquez C, Jayasekara WSN, Alamgeer M, Boolell V, Han JZR, Waugh T, Lee HC, Oakes SR, Kumar B, Harrison CA, Hedger MP, Lorensuhewa N, Kita B, Barrow R, Robinson BW, de Kretser DM, Wu J, Ganju V, Sweet-Cordero EA, Burgess A, Martelotto LG, Rossello FJ, Cain JE, Watkins DN. PMID: 30045976.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    41. Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell. 2018 01 08; 33(1):91-107.e6. Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA. PMID: 29316436; PMCID: PMC5761662.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    42. Statistical algorithms improve accuracy of gene fusion detection. Nucleic Acids Res. 2017 Jul 27; 45(13):e126. Hsieh G, Bierman R, Szabo L, Lee AG, Freeman DE, Watson N, Sweet-Cordero EA, Salzman J. PMID: 28541529; PMCID: PMC5737606.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Improvement in treatment abandonment in pediatric patients with cancer in Guatemala. Pediatr Blood Cancer. 2017 Oct; 64(10). Alvarez E, Seppa M, Rivas S, Fuentes L, Valverde P, Antillón-Klussmann F, Castellanos M, Sweet-Cordero EA, Messacar K, Kurap J, Bustamante M, Howard SC, Efron B, Luna-Fineman S. PMID: 28423236.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    44. An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer. Nat Commun. 2017 02 21; 8:14294. Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S. PMID: 28220783; PMCID: PMC5321758.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    45. Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis. Nat Med. 2017 Mar; 23(3):291-300. Chuang CH, Greenside PG, Rogers ZN, Brady JJ, Yang D, Ma RK, Caswell DR, Chiou SH, Winters AF, Grüner BM, Ramaswami G, Spencley AL, Kopecky KE, Sayles LC, Sweet-Cordero EA, Li JB, Kundaje A, Winslow MM. PMID: 28191885; PMCID: PMC6453542.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    46. An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency. Cancer Cell. 2016 05 09; 29(5):697-710. Brady JJ, Chuang CH, Greenside PG, Rogers ZN, Murray CW, Caswell DR, Hartmann U, Connolly AJ, Sweet-Cordero EA, Kundaje A, Winslow MM. PMID: 27150038; PMCID: PMC4864124.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    47. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015 Oct; 21(10):1163-71. Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT. PMID: 26390243; PMCID: PMC4959788.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    48. Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. J Clin Invest. 2014 Dec; 124(12):5275-90. Marques Howarth M, Simpson D, Ngok SP, Nieves B, Chen R, Siprashvili Z, Vaka D, Breese MR, Crompton BD, Alexe G, Hawkins DS, Jacobson D, Brunner AL, West R, Mora J, Stegmaier K, Khavari P, Sweet-Cordero EA. PMID: 25401475; PMCID: PMC4348951.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    49. A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma. Cancer Res. 2014 May 15; 74(10):2892-902. Chen R, Khatri P, Mazur PK, Polin M, Zheng Y, Vaka D, Hoang CD, Shrager J, Xu Y, Vicent S, Butte AJ, Sweet-Cordero EA. PMID: 24654231; PMCID: PMC4084668.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    50. Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. Oncogene. 2015 Jan 02; 34(1):94-103. Valdmanis PN, Roy-Chaudhuri B, Kim HK, Sayles LC, Zheng Y, Chuang CH, Caswell DR, Chu K, Zhang Y, Winslow MM, Sweet-Cordero EA, Kay MA. PMID: 24317514; PMCID: PMC4065842.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    51. A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. Cancer Cell. 2013 Jul 08; 24(1):59-74. Zheng Y, de la Cruz CC, Sayles LC, Alleyne-Chin C, Vaka D, Knaak TD, Bigos M, Xu Y, Hoang CD, Shrager JB, Fehling HJ, French D, Forrest W, Jiang Z, Carano RA, Barck KH, Jackson EL, Sweet-Cordero EA. PMID: 23845442; PMCID: PMC3923526.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    52. Two is better than one: combining IGF1R and MEK blockade as a promising novel treatment strategy against KRAS-mutant lung cancer. Cancer Discov. 2013 May; 3(5):491-3. Chen R, Sweet-Cordero EA. PMID: 23658296; PMCID: PMC6138247.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    53. The phosphatase PP2A links glutamine to the tumor suppressor p53. Mol Cell. 2013 Apr 25; 50(2):157-8. Gwinn D, Sweet-Cordero EA. PMID: 23622513.
      View in: PubMed   Mentions: 2     Fields:    
    54. Mathematical modeling of tumor cell proliferation kinetics and label retention in a mouse model of lung cancer. Cancer Res. 2013 Jun 15; 73(12):3525-33. Zheng Y, Moore H, Piryatinska A, Solis T, Sweet-Cordero EA. PMID: 23576555; PMCID: PMC3703454.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    55. Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer. Sci Transl Med. 2013 Feb 06; 5(171):171ra18. Hegde GV, de la Cruz CC, Chiu C, Alag N, Schaefer G, Crocker L, Ross S, Goldenberg D, Merchant M, Tien J, Shao L, Roth L, Tsai SP, Stawicki S, Jin Z, Wyatt SK, Carano RA, Zheng Y, Sweet-Cordero EA, Wu Y, Jackson EL. PMID: 23390248.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    56. Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity. PLoS One. 2012; 7(10):e45647. Hegde GV, de la Cruz C, Eastham-Anderson J, Zheng Y, Sweet-Cordero EA, Jackson EL. PMID: 23115623; PMCID: PMC3480356.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    57. Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo. Cancer Res. 2012 Nov 15; 72(22):5744-56. Vicent S, Sayles LC, Vaka D, Khatri P, Gevaert O, Chen R, Zheng Y, Gillespie AK, Clarke N, Xu Y, Shrager J, Hoang CD, Plevritis S, Butte AJ, Sweet-Cordero EA. PMID: 22962265; PMCID: PMC3856949.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    58. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. J Clin Invest. 2010 Nov; 120(11):3940-52. Vicent S, Chen R, Sayles LC, Lin C, Walker RG, Gillespie AK, Subramanian A, Hinkle G, Yang X, Saif S, Root DE, Huff V, Hahn WC, Sweet-Cordero EA. PMID: 20972333; PMCID: PMC2965578.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    59. Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res. 2010 May 15; 70(10):3877-83. Schaffer BE, Park KS, Yiu G, Conklin JF, Lin C, Burkhart DL, Karnezis AN, Sweet-Cordero EA, Sage J. PMID: 20406986; PMCID: PMC2873158.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimals
    60. Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 2010 Apr 15; 24(8):837-52. Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, Golub T, Thomale J, Jacks T, Sweet-Cordero EA. PMID: 20395368; PMCID: PMC2854397.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    61. Comparison of gene expression and DNA copy number changes in a murine model of lung cancer. Genes Chromosomes Cancer. 2006 Apr; 45(4):338-48. Sweet-Cordero A, Tseng GC, You H, Douglass M, Huey B, Albertson D, Jacks T. PMID: 16323170.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    62. An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. Nat Genet. 2005 Jan; 37(1):48-55. Sweet-Cordero A, Mukherjee S, Subramanian A, You H, Roix JJ, Ladd-Acosta C, Mesirov J, Golub TR, Jacks T. PMID: 15608639.
      View in: PubMed   Mentions: 197     Fields:    Translation:Animals
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