Loading...

William A. Weiss, MD, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone415-502-1694
ORCID ORCID Icon0000-0003-2230-9132 Additional info
vCardDownload vCard
    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Tufts University, Medford MABS1982Biology
    Stanford University, Stanford CAMD-PhD1989Medicine/Cancer Biology
    Children's Hospital , BostonResidency1991Pediatrics
    UCSFResidency1994Neurology/Child Neurology
    UCSFPostdoc 1988Cancer Biology (under J. Michael Bishop)

    Collapse Overview 
    Collapse Overview
    We develop and use in-vivo models for neural cancers to: 1) Identify genetic events that promote tumorigenesis. 2) Study cancer stem and progenitor cells. 3) Evaluate new targets, chemical genetic approaches, and mechanistic rationales for combining targeted agents.

    Stem cell biology, genetics, and developmental therapeutics in glioma. Aberrant EGFR signaling features prominently in glioma, the most common primary adult brain tumor. We generated a mouse model for glioma by over-expressing EGFR under the S100 beta promoter (Weiss, 2003). Expression of oncogenes in rare cancer-stem-like cells in the subventricular zone led to differentiation block and aberrant glial differentiation, resulting in astrocytoma (Persson, In revision). In contrast, murine oligodendrogliomas arose from abundant oligodendroglial progenitors in white matter. We described a progenitor origin for this more favorable form of glioma, demonstrating that a progenitor rather than a stem-cell origin underlies the improved outcome in patients (Persson, 2010). We were among the first to describe oncogene addiction driven by activated EGFR (Fan, 2002). We described and characterized dual inhibitors of PI3K and mTOR, demonstrating that these drugs blocked mTOR inhibitor-driven activation of Akt, that EGFR signaling to Akt was dispensable for arrest, that EGFR signaling to Protein Kinase C alpha was central to the ability of PI3K to signal to mTOR, and that blockade of PI3K, mTOR and autophagy converted cytostatic PI3K/mTOR inhibitors into cytotoxic agents (Fan, 2006-2010). Activated alleles of EGFR occur in brain and lung-cancers, yet EGFR inhibitors benefit only lung cancer. We traced this differential response to lower occupancy rates of EGFR inhibitors in brain as compared to lung cancer mutants (Barkovich 2012). EGFR is frequently co-amplified with EGFRvIII. We showed co-expression of EGFR and vIII in individual cells in human tumors, that vIII is a substrate for EGFR, and that co-expression drives STAT signaling (Fan et al, 2013).

    Targeted expression of MYCN generate models of neuroblastoma and medulloblastoma in transgenic mice. Neuroblastoma is the third most common tumor of childhood. The proto-oncogene MYCN is amplified in 25% of neuroblastomas, marking incurable disease. We generated transgenic mice that mis-expressed MYCN in neural crest, that developed neuroblastoma, and that remain the standard GEM model used by the community (Weiss et al, 1997). Genome-wide screens revealed genetic alignment with human tumors (Weiss et al, 2002, Hackett et al, 2003). Through systems biology approaches, we identified altered neurotransmitter signaling through GABA as contributing to human and murine neuroblastoma, and described the alternative splicing landscape (Hackett et al, 2014; Chen et al, 2015). Murine neuroblastoma tumors mutant at p53 were therapy resistant, modeling relapsed, drug-resistant neuroblastoma (Chesler, 2006-8). MYCN blockade reduced VEGF signaling, promoting vascular collapse (Chanthery, 2012). We synthesized and solved the co-crystal structure of a new class of MYC/MYCN-degrading drugs that block a kinase-independent MYC/MYCN stabilizing function of Aurora Kinase, potently degrading MYCN in-vivo (Gustafson, Meyerowitz, Cancer Cell, 2014).

    MYCN is mis-expresssed in the majority of medulloblastoma tumors. We used the Tet system to regulate MYCN expression and to image tumor-associated firefly luciferase expression in-vivo. Targeted expression of MYCN to the brains of transgenic mice led to luciferase and MYCN-positive medulloblastoma, (Swartling, 2010). We also transduced MYCN into murine neural stem cells, separately cultured from prenatal or postnatal mice, with cells from hindbrain generating medulloblastoma, and from forebrain generating glioma. Orthotopic transduction of prenatal cerebellar stem cells drove SHH-dependent, while both prenatal brainstem and postnatal cerebellar stem cells drove SHH-independent disease (Swartling 2012). Thus, distinct neural stem cell populations generated disparate brain tumors in response to MYCN.

    Genome-wide sequencing efforts have generally failed to identify new driver mutations for the majority of high-risk neuroblastoma and medulloblastoma. In contrast, copy number analyses have identified recurrent regions of variation. Regions of gain or loss on any human chromosome correspond to multiple different chromosomes in the mouse, which is challenging to model. Thus, we are incorporating known driver mutations into engineered human induced pluripotent stem cells, and have generated humanized mouse models for neuroblastoma and medulloblastoma. These human based xenograft models represent a genetic platform to test copy number variation as cancer drivers, and to develop therapies.


    LEADERSHIP. I am Professor of Neurology, Pediatrics, and Neurosurgery at UCSF, Director of Clinical Child Neurology at San Francisco General Hospital, Co-Leader of the Helen Diller Family Comprehensive Cancer Center’s Pediatrics Malignancies Program and Chair of the weekly seminar series in UCSF’s Helen Diller Family Comprehensive Cancer Center, and Project PI in UCSF’s Pediatric Brain Tumor Foundation Program. I edit Breaking Advances for Cancer Research, am associate editor of the NeuroOncology, Molecular and Cellular Biology, and Scientific Reports, serve on the Neuroblastoma Biology Committee for the Children’s Oncology Group, and am advise Research Programs at Stanford and at Saint Jude Children’s Research Hospital. I have organized two international meetings on mouse models for neural cancers for the NCI, was co-organizer of the Cold Spring Harbor Models and Mechanisms of Cancer meeting (2009-2014), and was founding organizer of the now annual Medulloblastoma in the Mountains, and Pediatric Infiltrating Glioma Meeings (which bring together international basic and clinical thought leaders to translate scientific findings into patient care). I was co-chair of the program meeting for the 2007 centennial AACR meeting, and have organized basic science sessions at annual AACR meetings for many years. I was an external advisor for programs at CHLA, Mayo Clinic and University of Calgary; and have been external reviewer of NCI’s Mouse Cancer Genetics Program (2003 and 2008) and of the Departments of Genetics and of Tumor Cell Biology at St. Jude’s Children’s Research Hospital (2009). I have been a good citizen of the NIH for many years, and was a permanent member of both the NINDS NSDA study section. I was also a permanent member of the Cancer Prevention and Research Institute of Texas (under Chuck Sherr).

    MENTORING RECORD. I formally mentor neurologists Li Gan (Associate Prof of Neurology at UCSF) Hannah Green, MD (Associate Prof of Neurology at UCSF), and Audrey Foster-Barber (Associate Prof of Pediatric Neurology at UCSF), David Young (fellow in Child Neurology), Christopher McGraw (resident in Neurology), and Abrar Choudhury (first year MSTP). Other mentees include Clay Gustafson, MD-PhD (K08 recipient and Alex Lemonade Stand Career Awardee, Asst Prof of Pediatrics at UCSF), Anders Persson, PhD (independent investigator and Assistant Professor of Neurology at UCSF), Theo Nicolaides, MD, (K08 recipient, independent investigator and Assistant Professor of Pediatrics at UCSF), Qi-Wen Fan, MD-PhD, (up for promotion to Associate Professor of Neurology at UCSF), and Lou Chesler (former K08 recipient and Professor at ICR in London). I was formally a mentor to Jonathan Hecht, MD-PhD (Assistant Prof of Pediatric Neurology, Stanford), Manu Hegde MD-PhD (Assistant Prof of Neurology, UCSF), Sabine Mueller, MD-PhD (Assistant Professor of Pediatric Neurology at UCSF), Kendall Nash, MD (Assistant Professor of Pediatric Neurology at UCSF), Kyle Steinman, MD (Assistant Prof of Pediatric Neurology, Univ of Washington) and Raquel Gardner (Assistant Professor at UCSF). In addition to Drs. Fan, Gustafson, Nicolaides, and Persson, above, my former postdoctoral fellow mentees also include Yvan Chanthery, PhD (now Asst Professor at Santa Clara University), Lou Chesler, MD-PhD (former K08 recipient and now full Professor and independent investigator at the Royal Marsden Hospital, ICR, UK), and Fredrik J. Swartling, PhD, (Assistant Professor and independent investigator at Uppsalla University, Sweden). I mentor on average 4-5 postdocs in my lab. Miller Huang, a postdoc in my lab, was awarded a K99 in 2016. I have mentored 4 PhD students (all have graduated) and three MD-PhD student (one graduated) in my own lab, as well as a large number of medical students and undergraduates. In addition, I mentor a large number of graduate students as a non-thesis advisor, and through sitting on qualifying exam and thesis committees.

    Collapse Research 
    Collapse Research Activities and Funding
    Prevention and treatment of lethal metastases in group 3 medulloblastoma
    NIH R01NS106155Sep 1, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Improving the efficacy of mTOR inhibition
    NIH/NCI R01CA221969Feb 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Discovering and Exploiting Mechanisms of Neuroblastoma Therapy Resistance
    NIH/NCI P01CA217959Sep 18, 2017 - Aug 31, 2022
    Role: Project Leader
    Integrating targeted and immunotherapy to treat genetically heterogeneous cancers
    NIH/NCI U01CA217864Aug 17, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Precision Medicine For Pediatric Low-Grade Gliomas
    NIH/NINDS R01NS091620Sep 30, 2015 - Jul 31, 2020
    Role: Co-Principal Investigator
    Targeting BET-bromodomains in neuroblastoma
    NIH/NINDS R01NS088355May 15, 2015 - Mar 31, 2020
    Role: Co-Principal Investigator
    MYCN, mTOR and translation control in medulloblastoma
    NIH/NINDS R01NS089868Sep 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Integrating mass cytometric and transcriptomic profiles of solid tumors
    NIH/NCI R33CA183692May 1, 2014 - Apr 30, 2017
    Role: Principal Investigator
    Genetic network analysis of cancer targets
    NIH/NCI U01CA176287Jun 7, 2013 - Apr 30, 2017
    Role: Principal Investigator
    Biophysical and molecular dialogue of glioma cells and the brain microenvironment
    NIH/NCI U54CA163155Sep 26, 2011 - Jul 31, 2016
    Role: Co-Investigator
    Mouse models to discover new drivers of medulloblastoma
    NIH/NCI R01CA159859Apr 4, 2011 - Mar 31, 2016
    Role: Co-Principal Investigator
    Medulloblastoma and Metastases
    NIH/NCI R01CA148699May 4, 2010 - Feb 28, 2015
    Role: Principal Investigator
    Mycn and Medulloblastoma
    NIH/NCI R01CA133091Jan 1, 2009 - Dec 31, 2013
    Role: Principal Investigator
    Modifiers of Tumor Susceptibility in Murine Neuroblastoma
    NIH/NINDS R01NS055750Dec 15, 2007 - Nov 30, 2012
    Role: Principal Investigator
    Imaging Kinase Activity In Vivo
    NIH/NINDS R21NS052161Jul 1, 2005 - Jun 30, 2007
    Role: Principal Investigator
    Murine Neuroblastoma Models for Preclinical Therapeutics
    NIH/NCI R01CA102321Jul 1, 2003 - Jun 30, 2017
    Role: Principal Investigator
    Brain Tumor SPORE Grant
    NIH/NCI P50CA097257Sep 20, 2002 - Aug 31, 2023
    Role: Project Basic Science Leader
    GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMA
    NIH/NINDS K02NS002226Sep 30, 2000 - Aug 31, 2005
    Role: Principal Investigator
    Biology and Therapy of High Risk Neuroblastoma
    NIH/NCI P01CA081403Jul 6, 2000 - May 31, 2015
    Role: Co-Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH/NCRR M01RR001271Dec 1, 1981 - Sep 29, 2006
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Utility of Human-Derived Models for Glioblastoma. Cancer Discov. 2020 Jul; 10(7):907-909. Luo X, Weiss WA. PMID: 32611734.
      View in: PubMed   Mentions:    Fields:    
    2. Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma. Cell Rep Med. 2020 Jun 23; 1(3). Nobre L, Zapotocky M, Khan S, Fukuoka K, Fonseca A, McKeown T, Sumerauer D, Vicha A, Grajkowska WA, Trubicka J, Li KKW, Ng HK, Massimi L, Lee JY, Kim SK, Zelcer S, Vasiljevic A, Faure-Conter C, Hauser P, Lach B, van Veelen-Vincent ML, French PJ, Van Meir EG, Weiss WA, Gupta N, Pollack IF, Hamilton RL, Nageswara Rao AA, Giannini C, Rubin JB, Moore AS, Chambless LB, Vibhakar R, Ra YS, Massimino M, McLendon RE, Wheeler H, Zollo M, Ferruci V, Kumabe T, Faria CC, Sterba J, Jung S, López-Aguilar E, Mora J, Carlotti CG, Olson JM, Leary S, Cain J, Krskova L, Zamecnik J, Hawkins CE, Tabori U, Huang A, Bartels U, Northcott PA, Taylor MD, Yip S, Hansford JR, Bouffet E, Ramaswamy V. PMID: 32743560.
      View in: PubMed   Mentions:
    3. Depatuxizumab Mafodotin (ABT-414)-induced Glioblastoma Cell Death Requires EGFR Overexpression, but not EGFRY1068 Phosphorylation. Mol Cancer Ther. 2020 06; 19(6):1328-1339. von Achenbach C, Silginer M, Blot V, Weiss WA, Weller M. PMID: 32371586.
      View in: PubMed   Mentions:
    4. Betacellulin drives therapy resistance in glioblastoma. Neuro Oncol. 2020 04 15; 22(4):457-469. Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA. PMID: 31678994.
      View in: PubMed   Mentions:    Fields:    
    5. Conversations on mutism: risk stratification for cerebellar mutism based on medulloblastoma subtype. Neuro Oncol. 2020 02 20; 22(2):175-176. Russ JB, Weiss WA. PMID: 31792531.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Translating Basic Science Discoveries into Improved Outcomes for Glioblastoma. Clin Cancer Res. 2020 Jun 01; 26(11):2457-2460. Dirks PB, Gilbert MR, Holland EC, Maher EA, Weiss WA. PMID: 32060102.
      View in: PubMed   Mentions:    Fields:    
    7. Cooperative Blockade of PKCa and JAK2 Drives Apoptosis in Glioblastoma. Cancer Res. 2020 02 15; 80(4):709-718. Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW. PMID: 31806641.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Correction: EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma. Cancer Res. 2019 Nov 01; 79(21):5681. An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA. PMID: 31676678.
      View in: PubMed   Mentions:    Fields:    
    9. ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer Cell. 2019 11 11; 36(5):512-527.e9. Qadeer ZA, Valle-Garcia D, Hasson D, Sun Z, Cook A, Nguyen C, Soriano A, Ma A, Griffiths LM, Zeineldin M, Filipescu D, Jubierre L, Chowdhury A, Deevy O, Chen X, Finkelstein DB, Bahrami A, Stewart E, Federico S, Gallego S, Dekio F, Fowkes M, Meni D, Maris JM, Weiss WA, Roberts SS, Cheung NV, Jin J, Segura MF, Dyer MA, Bernstein E. PMID: 31631027.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature. 2019 10; 574(7780):707-711. Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD. PMID: 31664194.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    11. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell. 2019 09 16; 36(3):302-318.e7. Zhang L, He X, Liu X, Zhang F, Huang LF, Potter AS, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones BV, Fouladi M, Drissi R, Yang ZJ, Gustafson WC, Remke M, Pomeroy SL, Girard EJ, Olson JM, Morrissy AS, Vladoiu MC, Zhang J, Tian W, Xin M, Taylor MD, Potter SS, Roussel MF, Weiss WA, Lu QR. PMID: 31474569.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. Cell Rep. 2019 08 27; 28(9):2317-2330.e8. Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, Asthana S, Ideker T, Wu W, Suzuki J, Barad BA, Kirichok Y, Fraser JS, Weiss WA, Krogan NJ, Tulpule A, Sabnis AJ, Bivona TG. PMID: 31461649.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness. Cell Rep. 2019 08 20; 28(8):2064-2079.e11. Sabelström H, Petri R, Shchors K, Jandial R, Schmidt C, Sacheva R, Masic S, Yuan E, Fenster T, Martinez M, Saxena S, Nicolaides TP, Ilkhanizadeh S, Berger MS, Snyder EY, Weiss WA, Jakobsson J, Persson AI. PMID: 31433983.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. In Vitro Assay to Study Tumor-macrophage Interaction. J Vis Exp. 2019 08 01; (150). An Z, Weiss WA. PMID: 31424440.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM. Mol Cancer Ther. 2019 09; 18(9):1565-1576. McKinney A, Lindberg OR, Engler JR, Chen KY, Kumar A, Gong H, Lu KV, Simonds EF, Cloughesy TF, Liau LM, Prados M, Bollen AW, Berger MS, Shieh JTC, James CD, Nicolaides TP, Yong WH, Lai A, Hegi ME, Weiss WA, Phillips JJ. PMID: 31270152.
      View in: PubMed   Mentions:
    16. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell Stem Cell. 2019 09 05; 25(3):433-446.e7. Huang M, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA. PMID: 31204176.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun. 2019 01 18; 10(1):332. Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, Northcott PA, Wechsler-Reya RJ. PMID: 30659187.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints. Blood. 2019 03 07; 133(10):1119-1129. Andor N, Simonds EF, Czerwinski DK, Chen J, Grimes SM, Wood-Bouwens C, Zheng GXY, Kubit MA, Greer S, Weiss WA, Levy R, Ji HP. PMID: 30591526.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling. Cancer Cell. 2018 12 10; 34(6):922-938.e7. Iniguez AB, Alexe G, Wang EJ, Roti G, Patel S, Chen L, Kitara S, Conway A, Robichaud AL, Stolte B, Bandopadhayay P, Goodale A, Pantel S, Lee Y, Cheff DM, Hall MD, Guha R, Davis MI, Menard M, Nasholm N, Weiss WA, Qi J, Beroukhim R, Piccioni F, Johannessen C, Stegmaier K. PMID: 30537514.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. GateFinder: projection-based gating strategy optimization for flow and mass cytometry. Bioinformatics. 2018 12 01; 34(23):4131-4133. Aghaeepour N, Simonds EF, Knapp DJHF, Bruggner RV, Sachs K, Culos A, Gherardini PF, Samusik N, Fragiadakis GK, Bendall SC, Gaudilliere B, Angst MS, Eaves CJ, Weiss WA, Fantl WJ, Nolan GP. PMID: 29850785.
      View in: PubMed   Mentions: 6     Fields:    
    21. A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 02 15; 25(4):1379-1388. Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ. PMID: 30487124.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. An oncolytic measles virus-sensitive Group 3 medulloblastoma model in immune-competent mice. Neuro Oncol. 2018 11 12; 20(12):1606-1615. Lal S, Carrera D, Phillips JJ, Weiss WA, Raffel C. PMID: 29912438.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    23. EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma. Cancer Res. 2018 12 15; 78(24):6785-6794. An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA. PMID: 30401716.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 05 31; 173(6):1549. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29856958.
      View in: PubMed   Mentions: 4     Fields:    
    25. Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. Cancer Res. 2018 07 15; 78(14):4007-4021. Pal S, Kozono D, Yang X, Fendler W, Fitts W, Ni J, Alberta JA, Zhao J, Liu KX, Bian J, Truffaux N, Weiss WA, Resnick AC, Bandopadhayay P, Ligon KL, DuBois SG, Mueller S, Chowdhury D, Haas-Kogan DA. PMID: 29760046.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-ß-OTX2-SNAIL via PTEN inhibition. Brain. 2018 05 01; 141(5):1300-1319. Ferrucci V, de Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor MD, Cinalli G, Zollo M. PMID: 29490009.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018 05 14; 33(5):874-889.e7. Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH. PMID: 29681511.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma. Oncogene. 2018 05; 37(21):2850-2862. Bolin S, Borgenvik A, Persson CU, Sundström A, Qi J, Bradner JE, Weiss WA, Cho YJ, Weishaupt H, Swartling FJ. PMID: 29511348.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018 02 22; 172(5):1050-1062.e14. Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD. PMID: 29474906.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    30. Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. Mol Cancer Res. 2018 05; 16(5):777-790. Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI. PMID: 29431617.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    31. Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies. Oncogene. 2018 03; 37(12):1561-1575. An Z, Aksoy O, Zheng T, Fan QW, Weiss WA. PMID: 29321659.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    32. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest. 2018 01 02; 128(1):446-462. Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, Ali LD, Pantel S, Jiang G, Harrington WF, Lee Y, Goodale A, Lubonja R, Krill-Burger JM, Meyers RM, Tsherniak A, Root DE, Bradner JE, Golub TR, Roberts CW, Hahn WC, Weiss WA, Thiele CJ, Stegmaier K. PMID: 29202477.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    33. Neuroblastoma Metastases: Leveraging the Avian Neural Crest. Cancer Cell. 2017 10 09; 32(4):395-397. Zheng T, Ménard M, Weiss WA. PMID: 29017050.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    34. Cross-activating c-Met/ß1 integrin complex drives metastasis and invasive resistance in cancer. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8685-E8694. Jahangiri A, Nguyen A, Chandra A, Sidorov MK, Yagnik G, Rick J, Han SW, Chen W, Flanigan PM, Schneidman-Duhovny D, Mascharak S, De Lay M, Imber B, Park CC, Matsumoto K, Lu K, Bergers G, Sali A, Weiss WA, Aghi MK. PMID: 28973887.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    35. CNS Anticancer Drug Discovery and Development: 2016 conference insights. CNS Oncol. 2017 Jul; 6(3):167-177. Levin VA, Abrey LE, Heffron TP, Tonge PJ, Dar AC, Weiss WA, Gallo JM. PMID: 28718326.
      View in: PubMed   Mentions:    Fields:    
    36. Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma. Oncogene. 2017 11 09; 36(45):6306-6314. Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ. PMID: 28714964.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    37. Inhibiting 4EBP1 in Glioblastoma. Clin Cancer Res. 2018 01 01; 24(1):14-21. Fan QW, Nicolaides TP, Weiss WA. PMID: 28696243.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    38. Glioblastoma cellular cross-talk converges on NF-?B to attenuate EGFR inhibitor sensitivity. Genes Dev. 2017 06 15; 31(12):1212-1227. Zanca C, Villa GR, Benitez JA, Thorne AH, Koga T, D'Antonio M, Ikegami S, Ma J, Boyer AD, Banisadr A, Jameson NM, Parisian AD, Eliseeva OV, Barnabe GF, Liu F, Wu S, Yang H, Wykosky J, Frazer KA, Verkhusha VV, Isaguliants MG, Weiss WA, Gahman TC, Shiau AK, Chen CC, Mischel PS, Cavenee WK, Furnari FB. PMID: 28724615.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Intertumoral Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 2017 06 12; 31(6):737-754.e6. Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, Garzia L, Torchia J, Nor C, Morrissy AS, Agnihotri S, Thompson YY, Kuzan-Fischer CM, Farooq H, Isaev K, Daniels C, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska WA, Perek-Polnik M, Vasiljevic A, Faure-Conter C, Jouvet A, Giannini C, Nageswara Rao AA, Li KKW, Ng HK, Eberhart CG, Pollack IF, Hamilton RL, Gillespie GY, Olson JM, Leary S, Weiss WA, Lach B, Chambless LB, Thompson RC, Cooper MK, Vibhakar R, Hauser P, van Veelen MC, Kros JM, French PJ, Ra YS, Kumabe T, López-Aguilar E, Zitterbart K, Sterba J, Finocchiaro G, Massimino M, Van Meir EG, Osuka S, Shofuda T, Klekner A, Zollo M, Leonard JR, Rubin JB, Jabado N, Albrecht S, Mora J, Van Meter TE, Jung S, Moore AS, Hallahan AR, Chan JA, Tirapelli DPC, Carlotti CG, Fouladi M, Pimentel J, Faria CC, Saad AG, Massimi L, Liau LM, Wheeler H, Nakamura H, Elbabaa SK, Perezpeña-Diazconti M, Chico Ponce de León F, Robinson S, Zapotocky M, Lassaletta A, Huang A, Hawkins CE, Tabori U, Bouffet E, Bartels U, Dirks PB, Rutka JT, Bader GD, Reimand J, Goldenberg A, Ramaswamy V, Taylor MD. PMID: 28609654.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    40. Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia. Antimicrob Agents Chemother. 2017 04; 61(4). Diep BA, Hilliard JJ, Le VT, Tkaczyk C, Le HN, Tran VG, Rao RL, Dip EC, Pereira-Franchi EP, Cha P, Jacobson S, Broome R, Cheng LI, Weiss W, Prokai L, Nguyen V, Stover CK, Sellman BR. PMID: 28115346.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 2017 03 13; 31(3):424-435. Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA. PMID: 28292440.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    42. Pediatric high-grade glioma: biologically and clinically in need of new thinking. Neuro Oncol. 2017 02 01; 19(2):153-161. Jones C, Karajannis MA, Jones DTW, Kieran MW, Monje M, Baker SJ, Becher OJ, Cho YJ, Gupta N, Hawkins C, Hargrave D, Haas-Kogan DA, Jabado N, Li XN, Mueller S, Nicolaides T, Packer RJ, Persson AI, Phillips JJ, Simonds EF, Stafford JM, Tang Y, Pfister SM, Weiss WA. PMID: 27282398.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    43. Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas. Oncotarget. 2017 Jan 03; 8(1):583-595. Yao TW, Zhang J, Prados M, Weiss WA, James CD, Nicolaides T. PMID: 27611946.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    44. Breast density estimation from high spectral and spatial resolution MRI. J Med Imaging (Bellingham). 2016 Oct; 3(4):044507. Li H, Weiss WA, Medved M, Abe H, Newstead GM, Karczmar GS, Giger ML. PMID: 28042590.
      View in: PubMed   Mentions:
    45. Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas. J Neurooncol. 2017 02; 131(3):495-505. Zhang J, Yao TW, Hashizume R, Hariono S, Barkovich KJ, Fan QW, Prados M, James CD, Weiss WA, Nicolaides T. PMID: 27848137.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    46. Cholesterol: An Achilles' Heel for Glioblastoma? Cancer Cell. 2016 11 14; 30(5):653-654. An Z, Weiss WA. PMID: 27846382.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    47. Neuroblastoma. Nat Rev Dis Primers. 2016 11 10; 2:16078. Matthay KK, Maris JM, Schleiermacher G, Nakagawara A, Mackall CL, Diller L, Weiss WA. PMID: 27830764.
      View in: PubMed   Mentions: 129     Fields:    Translation:Humans
    48. IKK/NF-?B signaling contributes to glioblastoma stem cell maintenance. Oncotarget. 2016 Oct 25; 7(43):69173-69187. Rinkenbaugh AL, Cogswell PC, Calamini B, Dunn DE, Persson AI, Weiss WA, Lo DC, Baldwin AS. PMID: 27732951.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    49. Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections. Antimicrob Agents Chemother. 2016 10; 60(10):5640-8. Le VT, Tkaczyk C, Chau S, Rao RL, Dip EC, Pereira-Franchi EP, Cheng L, Lee S, Koelkebeck H, Hilliard JJ, Yu XQ, Datta V, Nguyen V, Weiss W, Prokai L, O'Day T, Stover CK, Sellman BR, Diep BA. PMID: 27401576.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    50. Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors. Oncotarget. 2016 09 06; 7(36):57525-57544. Vaughan L, Clarke PA, Barker K, Chanthery Y, Gustafson CW, Tucker E, Renshaw J, Raynaud F, Li X, Burke R, Jamin Y, Robinson SP, Pearson A, Maira M, Weiss WA, Workman P, Chesler L. PMID: 27438153.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    51. BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. Clin Cancer Res. 2016 Nov 01; 22(21):5312-5321. Olow A, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick AC, Waanders AJ, Stalpers LJ, Berger MS, Gupta N, James CD, Petritsch CK, Haas-Kogan DA. PMID: 27217440.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    52. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis. Lancet Oncol. 2016 04; 17(4):484-495. Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Gururangan S, McLendon RE, Bigner DD, Lipp ES, Perreault S, Cho YJ, Grant G, Kim SK, Lee JY, Rao AAN, Giannini C, Li KKW, Ng HK, Yao Y, Kumabe T, Tominaga T, Grajkowska WA, Perek-Polnik M, Low DCY, Seow WT, Chang KTE, Mora J, Pollack IF, Hamilton RL, Leary S, Moore AS, Ingram WJ, Hallahan AR, Jouvet A, Fèvre-Montange M, Vasiljevic A, Faure-Conter C, Shofuda T, Kagawa N, Hashimoto N, Jabado N, Weil AG, Gayden T, Wataya T, Shalaby T, Grotzer M, Zitterbart K, Sterba J, Kren L, Hortobágyi T, Klekner A, László B, Pócza T, Hauser P, Schüller U, Jung S, Jang WY, French PJ, Kros JM, van Veelen MC, Massimi L, Leonard JR, Rubin JB, Vibhakar R, Chambless LB, Cooper MK, Thompson RC, Faria CC, Carvalho A, Nunes S, Pimentel J, Fan X, Muraszko KM, López-Aguilar E, Lyden D, Garzia L, Shih DJH, Kijima N, Schneider C, Adamski J, Northcott PA, Kool M, Jones DTW, Chan JA, Nikolic A, Garre ML, Van Meir EG, Osuka S, Olson JJ, Jahangiri A, Castro BA, Gupta N, Weiss WA, Moxon-Emre I, Mabbott DJ, Lassaletta A, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD. PMID: 26976201.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    53. Erratum to: Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma. J Neurooncol. 2016 Feb; 126(3):395. Dasgupta T, Olow AK, Yang X, Hashizume R, Nicolaides TP, Tom M, Aoki Y, Berger MS, Weiss WA, Stalpers LJ, Prados M, James CD, Mueller S, Haas-Kogan DA. PMID: 26782702.
      View in: PubMed   Mentions:    Fields:    
    54. Generating trunk neural crest from human pluripotent stem cells. Sci Rep. 2016 Jan 27; 6:19727. Huang M, Miller ML, McHenry LK, Zheng T, Zhen Q, Ilkhanizadeh S, Conklin BR, Bronner ME, Weiss WA. PMID: 26812940.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    55. Divergent clonal selection dominates medulloblastoma at recurrence. Nature. 2016 Jan 21; 529(7586):351-7. Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Ma Y, Tse K, Zeng T, Shumansky K, Roth AJ, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJ, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michealraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfield YS, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Nunes S, Shalaby T, Grotzer M, Pollack IF, Hamilton RL, Li XN, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff JH, Garvin JH, Stearns DS, Massimi L, Schüller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DP, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischhack G, Tippelt S, Ra YS, Bailey S, Lindsey JC, Clifford SC, Eberhart CG, Cooper MK, Packer RJ, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins CE, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DT, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones SJ, Malkin D, Marra MA, Taylor MD. PMID: 26760213.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    56. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016 Feb; 25(2):308-15. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. PMID: 26549191.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    57. Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma. J Neurooncol. 2016 Feb; 126(3):385-93. Dasgupta T, Olow AK, Yang X, Hashizume R, Nicolaides TP, Tom M, Aoki Y, Berger MS, Weiss WA, Stalpers LJ, Prados M, James CD, Mueller S, Haas-Kogan DA. PMID: 26384810.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    58. EGFR blockade prevents glioma escape from BRAFV600E targeted therapy. Oncotarget. 2015 Sep 08; 6(26):21993-2005. Yao TW, Zhang J, Prados M, Weiss WA, James CD, Nicolaides T. PMID: 26023796.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    59. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res. 2015 Oct 15; 75(20):4302-11. Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. PMID: 26282165.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    60. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 2015 Sep; 18(9):1236-46. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. PMID: 26258683.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    61. Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Front Oncol. 2015; 5:111. Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. PMID: 26029667.
      View in: PubMed   Mentions:
    62. Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype. Clin Cancer Res. 2015 Aug 15; 21(16):3750-8. Mack SC, Agnihotri S, Bertrand KC, Wang X, Shih DJ, Witt H, Hill N, Zayne K, Barszczyk M, Ramaswamy V, Remke M, Thompson Y, Ryzhova M, Massimi L, Grajkowska W, Lach B, Gupta N, Weiss WA, Guha A, Hawkins C, Croul S, Rutka JT, Pfister SM, Korshunov A, Pekmezci M, Tihan T, Philips JJ, Jabado N, Zadeh G, Taylor MD. PMID: 25957288.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    63. Preliminary assessment of dispersion versus absorption analysis of high spectral and spatial resolution magnetic resonance images in the diagnosis of breast cancer. J Med Imaging (Bellingham). 2015 Apr; 2(2):024502. Weiss WA, Medved M, Karczmar GS, Giger ML. PMID: 26158106.
      View in: PubMed   Mentions:
    64. A new "angle" on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition. Mol Cell Oncol. 2015 Apr-Jun; 2(2):e975641. Meyerowitz JG, Weiss WA, Gustafson WC. PMID: 27308435.
      View in: PubMed   Mentions:
    65. The genetics of splicing in neuroblastoma. Cancer Discov. 2015 Apr; 5(4):380-95. Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA. PMID: 25637275.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    66. WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma. Acta Neuropathol Commun. 2014 Dec 24; 2:174. Zhukova N, Ramaswamy V, Remke M, Martin DC, Castelo-Branco P, Zhang CH, Fraser M, Tse K, Poon R, Shih DJ, Baskin B, Ray PN, Bouffet E, Dirks P, von Bueren AO, Pfaff E, Korshunov A, Jones DT, Northcott PA, Kool M, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T, Gessi M, Rutkowski S, Bognár L, Cho BK, Eberhart CG, Conter CF, Fouladi M, French PJ, Grajkowska WA, Gupta N, Hauser P, Jabado N, Vasiljevic A, Jung S, Kim SK, Klekner A, Kumabe T, Lach B, Leonard JR, Liau LM, Massimi L, Pollack IF, Ra YS, Rubin JB, Van Meir EG, Wang KC, Weiss WA, Zitterbart K, Bristow RG, Alman B, Hawkins CE, Malkin D, Clifford SC, Pfister SM, Taylor MD, Tabori U. PMID: 25539912.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    67. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. . 2015 Feb; 14(2):419-28. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. PMID: 25522764.
      View in: PubMed   Mentions:
    68. Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Cancer Cell. 2015 Jan 12; 27(1):72-84. Hill RM, Kuijper S, Lindsey JC, Petrie K, Schwalbe EC, Barker K, Boult JK, Williamson D, Ahmad Z, Hallsworth A, Ryan SL, Poon E, Robinson SP, Ruddle R, Raynaud FI, Howell L, Kwok C, Joshi A, Nicholson SL, Crosier S, Ellison DW, Wharton SB, Robson K, Michalski A, Hargrave D, Jacques TS, Pizer B, Bailey S, Swartling FJ, Weiss WA, Chesler L, Clifford SC. PMID: 25533335.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    69. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Rep. 2014 Nov 06; 9(3):1034-46. Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA. PMID: 25437558.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    70. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 08; 26(3):414-427. Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. PMID: 25175806.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    71. When deletions gain functions: commandeering epigenetic mechanisms. Cancer Cell. 2014 Aug 11; 26(2):160-1. Chen J, Weiss WA. PMID: 25117708.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    72. An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun. 2014 May 15; 5:3626. Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. PMID: 24832154.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    73. Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy. Int J Cancer. 2014 May 15; 134(10):2437-47. Weller M, Kaulich K, Hentschel B, Felsberg J, Gramatzki D, Pietsch T, Simon M, Westphal M, Schackert G, Tonn JC, von Deimling A, Davis T, Weiss WA, Loeffler M, Reifenberger G. PMID: 24614983.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    74. The prenatal origins of cancer. Nat Rev Cancer. 2014 04; 14(4):277-89. Marshall GM, Carter DR, Cheung BB, Liu T, Mateos MK, Meyerowitz JG, Weiss WA. PMID: 24599217.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    75. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. 2014 Feb 27; 506(7489):445-50. Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stütz AM, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones DT, Sill M, Pugh TJ, Ryzhova M, Wani KM, Shih DJ, Head R, Remke M, Bailey SD, Zichner T, Faria CC, Barszczyk M, Stark S, Seker-Cin H, Hutter S, Johann P, Bender S, Hovestadt V, Tzaridis T, Dubuc AM, Northcott PA, Peacock J, Bertrand KC, Agnihotri S, Cavalli FM, Clarke I, Nethery-Brokx K, Creasy CL, Verma SK, Koster J, Wu X, Yao Y, Milde T, Sin-Chan P, Zuccaro J, Lau L, Pereira S, Castelo-Branco P, Hirst M, Marra MA, Roberts SS, Fults D, Massimi L, Cho YJ, Van Meter T, Grajkowska W, Lach B, Kulozik AE, von Deimling A, Witt O, Scherer SW, Fan X, Muraszko KM, Kool M, Pomeroy SL, Gupta N, Phillips J, Huang A, Tabori U, Hawkins C, Malkin D, Kongkham PN, Weiss WA, Jabado N, Rutka JT, Bouffet E, Korbel JO, Lupien M, Aldape KD, Bader GD, Eils R, Lichter P, Dirks PB, Pfister SM, Korshunov A, Taylor MD. PMID: 24553142.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    76. Cytogenetic prognostication within medulloblastoma subgroups. J Clin Oncol. 2014 Mar 20; 32(9):886-96. Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria CC, Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan JA, Robinson S, Bognár L, Klekner A, Saad AG, Liau LM, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Phillips JJ, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M, Jouvet A, Jabado N, Pollack IF, Weiss WA, Lee JY, Cho BK, Kim SK, Wang KC, Leonard JR, Rubin JB, de Torres C, Lavarino C, Mora J, Cho YJ, Tabori U, Olson JM, Gajjar A, Packer RJ, Rutkowski S, Pomeroy SL, French PJ, Kloosterhof NK, Kros JM, Van Meir EG, Clifford SC, Bourdeaut F, Delattre O, Doz FF, Hawkins CE, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka JT, Pfister SM, Taylor MD. PMID: 24493713.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    77. Alternative splicing in cancer: implications for biology and therapy. Oncogene. 2015 Jan 02; 34(1):1-14. Chen J, Weiss WA. PMID: 24441040.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    78. Residual analysis of the water resonance signal in breast lesions imaged with high spectral and spatial resolution (HiSS) MRI: a pilot study. Med Phys. 2014 Jan; 41(1):012303. Weiss WA, Medved M, Karczmar GS, Giger ML. PMID: 24387524.
      View in: PubMed   Mentions: 3     Fields:    
    79. Glial progenitors as targets for transformation in glioma. Adv Cancer Res. 2014; 121:1-65. Ilkhanizadeh S, Lau J, Huang M, Foster DJ, Wong R, Frantz A, Wang S, Weiss WA, Persson AI. PMID: 24889528.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    80. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014 Jan 10; 343(6167):189-193. Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS, Olshen AB, Cha S, Zhao Y, Moore RA, Mungall AJ, Jones SJM, Hirst M, Marra MA, Saito N, Aburatani H, Mukasa A, Berger MS, Chang SM, Taylor BS, Costello JF. PMID: 24336570.
      View in: PubMed   Mentions: 391     Fields:    Translation:Humans
    81. BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15; 20(4):912-25. Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, Bolin S, Schumacher SE, Zeid R, Masoud S, Yu F, Vue N, Gibson WJ, Paolella BR, Mitra SS, Cheshier SH, Qi J, Liu KW, Wechsler-Reya R, Weiss WA, Swartling FJ, Kieran MW, Bradner JE, Beroukhim R, Cho YJ. PMID: 24297863.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    82. Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. Acta Neuropathol. 2014 Feb; 127(2):189-201. Gottardo NG, Hansford JR, McGlade JP, Alvaro F, Ashley DM, Bailey S, Baker DL, Bourdeaut F, Cho YJ, Clay M, Clifford SC, Cohn RJ, Cole CH, Dallas PB, Downie P, Doz F, Ellison DW, Endersby R, Fisher PG, Hassall T, Heath JA, Hii HL, Jones DT, Junckerstorff R, Kellie S, Kool M, Kotecha RS, Lichter P, Laughton SJ, Lee S, McCowage G, Northcott PA, Olson JM, Packer RJ, Pfister SM, Pietsch T, Pizer B, Pomeroy SL, Remke M, Robinson GW, Rutkowski S, Schoep T, Shelat AA, Stewart CF, Sullivan M, Taylor MD, Wainwright B, Walwyn T, Weiss WA, Williamson D, Gajjar A. PMID: 24264598.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    83. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol. 2013 Dec; 126(6):917-29. Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, Zhukova N, Vanner R, Kros JM, French PJ, Van Meir EG, Vibhakar R, Zitterbart K, Chan JA, Bognár L, Klekner A, Lach B, Jung S, Saad AG, Liau LM, Albrecht S, Zollo M, Cooper MK, Thompson RC, Delattre OO, Bourdeaut F, Doz FF, Garami M, Hauser P, Carlotti CG, Van Meter TE, Massimi L, Fults D, Pomeroy SL, Kumabe T, Ra YS, Leonard JR, Elbabaa SK, Mora J, Rubin JB, Cho YJ, McLendon RE, Bigner DD, Eberhart CG, Fouladi M, Wechsler-Reya RJ, Faria CC, Croul SE, Huang A, Bouffet E, Hawkins CE, Dirks PB, Weiss WA, Schüller U, Pollack IF, Rutkowski S, Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grajkowska WA, Kim SK, Rutka JT, Malkin D, Tabori U, Pfister SM, Korshunov A, von Deimling A, Taylor MD. PMID: 24174164.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    84. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14; 24(4):438-49. Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. PMID: 24135280.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    85. Fundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer. Epigenetics. 2013 Dec; 8(12):1254-60. Diede SJ, Yao Z, Keyes CC, Tyler AE, Dey J, Hackett CS, Elsaesser K, Kemp CJ, Neiman PE, Weiss WA, Olson JM, Tapscott SJ. PMID: 24107773.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    86. It takes two to tango: Dual inhibition of PI3K and MAPK in rhabdomyosarcoma. Clin Cancer Res. 2013 Nov 01; 19(21):5811-3. Jahangiri A, Weiss WA. PMID: 24097859.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    87. Neuroblastoma and MYCN. Cold Spring Harb Perspect Med. 2013 Oct 01; 3(10):a014415. Huang M, Weiss WA. PMID: 24086065.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCells
    88. Starvation favors glioma stem cells. Nat Neurosci. 2013 Oct; 16(10):1359-61. Ilkhanizadeh S, Weiss WA. PMID: 24067285.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    89. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013 Sep 10; 2:e00508. Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. PMID: 24040509.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    90. Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 09; 6(283):ra55. He K, Qi Q, Chan CB, Xiao G, Liu X, Tucker-Burden C, Wang L, Mao H, Lu X, McDonald FE, Luo H, Fan QW, Weiss WA, Sun SY, Brat DJ, Ye K. PMID: 23838182.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    91. Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma. J Clin Oncol. 2013 Aug 10; 31(23):2927-35. Zhukova N, Ramaswamy V, Remke M, Pfaff E, Shih DJ, Martin DC, Castelo-Branco P, Baskin B, Ray PN, Bouffet E, von Bueren AO, Jones DT, Northcott PA, Kool M, Sturm D, Pugh TJ, Pomeroy SL, Cho YJ, Pietsch T, Gessi M, Rutkowski S, Bognar L, Klekner A, Cho BK, Kim SK, Wang KC, Eberhart CG, Fevre-Montange M, Fouladi M, French PJ, Kros M, Grajkowska WA, Gupta N, Weiss WA, Hauser P, Jabado N, Jouvet A, Jung S, Kumabe T, Lach B, Leonard JR, Rubin JB, Liau LM, Massimi L, Pollack IF, Shin Ra Y, Van Meir EG, Zitterbart K, Schüller U, Hill RM, Lindsey JC, Schwalbe EC, Bailey S, Ellison DW, Hawkins C, Malkin D, Clifford SC, Korshunov A, Pfister S, Taylor MD, Tabori U. PMID: 23835706.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    92. A robust method to derive functional neural crest cells from human pluripotent stem cells. Am J Stem Cells. 2013; 2(2):119-31. Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR. PMID: 23862100.
      View in: PubMed   Mentions:
    93. What underlies the diversity of brain tumors? Cancer Metastasis Rev. 2013 Jun; 32(1-2):5-24. Swartling FJ, Hede SM, Weiss WA. PMID: 23085857.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    94. G34, another connection between MYCN and a pediatric tumor. Cancer Discov. 2013 May; 3(5):484-6. Huang M, Weiss WA. PMID: 23658294.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    95. Molecular imaging of neuroblastoma progression in TH-MYCN transgenic mice. Mol Imaging Biol. 2013 Apr; 15(2):194-202. Quarta C, Cantelli E, Nanni C, Ambrosini V, D'ambrosio D, Di Leo K, Angelucci S, Zagni F, Lodi F, Marengo M, Weiss WA, Pession A, Tonelli R, Fanti S. PMID: 22777578.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    96. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1480-9. Shchors K, Persson AI, Rostker F, Tihan T, Lyubynska N, Li N, Swigart LB, Berger MS, Hanahan D, Weiss WA, Evan GI. PMID: 23542378.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    97. Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis. Cancer Res. 2013 Jul 01; 73(13):4086-97. Teitz T, Inoue M, Valentine MB, Zhu K, Rehg JE, Zhao W, Finkelstein D, Wang YD, Johnson MD, Calabrese C, Rubinstein M, Hakem R, Weiss WA, Lahti JM. PMID: 23536557.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    98. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar; 3(3):308-23. Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K. PMID: 23430699.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansAnimalsCells
    99. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. PMID: 22382618.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    100. Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathol. 2013 Mar; 125(3):373-84. Dubuc AM, Remke M, Korshunov A, Northcott PA, Zhan SH, Mendez-Lago M, Kool M, Jones DT, Unterberger A, Morrissy AS, Shih D, Peacock J, Ramaswamy V, Rolider A, Wang X, Witt H, Hielscher T, Hawkins C, Vibhakar R, Croul S, Rutka JT, Weiss WA, Jones SJ, Eberhart CG, Marra MA, Pfister SM, Taylor MD. PMID: 23184418.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    101. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012 Aug 02; 488(7409):49-56. Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD. PMID: 22832581.
      View in: PubMed   Mentions: 279     Fields:    Translation:HumansCells
    102. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15; 26(16):1780-96. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. PMID: 22855790.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    103. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12722-7. Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. PMID: 22802621.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    104. PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome. Neuro Oncol. 2012 Sep; 14(9):1146-52. Mueller S, Phillips J, Onar-Thomas A, Romero E, Zheng S, Wiencke JK, McBride SM, Cowdrey C, Prados MD, Weiss WA, Berger MS, Gupta N, Haas-Kogan DA. PMID: 22753230.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    105. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell. 2012 May 15; 21(5):601-13. Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips JJ, Taylor MD, Weiss WA. PMID: 22624711.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    106. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. PMID: 22586120.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    107. Matching mice to malignancy: molecular subgroups and models of medulloblastoma. Childs Nerv Syst. 2012 Apr; 28(4):521-32. Lau J, Schmidt C, Markant SL, Taylor MD, Wechsler-Reya RJ, Weiss WA. PMID: 22315164.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    108. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. PMID: 22966490.
      View in: PubMed   Mentions: 1495     Fields:    Translation:HumansAnimals
    109. Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discov. 2012 May; 2(5):450-7. Barkovich KJ, Hariono S, Garske AL, Zhang J, Blair JA, Fan QW, Shokat KM, Nicolaides T, Weiss WA. PMID: 22588882.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    110. Subgroup-specific alternative splicing in medulloblastoma. Acta Neuropathol. 2012 Apr; 123(4):485-499. Dubuc AM, Morrissy AS, Kloosterhof NK, Northcott PA, Yu EP, Shih D, Peacock J, Grajkowska W, van Meter T, Eberhart CG, Pfister S, Marra MA, Weiss WA, Scherer SW, Rutka JT, French PJ, Taylor MD. PMID: 22358458.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    111. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature. 2012 Feb 15; 482(7386):529-33. Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD. PMID: 22343890.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    112. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 2012 Jan 04; 4(115):115ra3. Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA. PMID: 22218692.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    113. Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors. Methods Mol Biol. 2012; 821:349-59. Fan QW, Weiss WA. PMID: 22125077.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    114. Biological and clinical heterogeneity of MYCN-amplified medulloblastoma. Acta Neuropathol. 2012 Apr; 123(4):515-27. Korshunov A, Remke M, Kool M, Hielscher T, Northcott PA, Williamson D, Pfaff E, Witt H, Jones DT, Ryzhova M, Cho YJ, Wittmann A, Benner A, Weiss WA, von Deimling A, Scheurlen W, Kulozik AE, Clifford SC, Peter Collins V, Westermann F, Taylor MD, Lichter P, Pfister SM. PMID: 22160402.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    115. Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res. 2011 Dec 15; 17(24):7595-604. Nicolaides TP, Li H, Solomon DA, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim JS, Rowitch DH, Weiss WA, Waldman TA, James CD. PMID: 22038996.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    116. Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma. Semin Cancer Biol. 2011 Oct; 21(4):245-55. Chesler L, Weiss WA. PMID: 21958944.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    117. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. PMID: 21907924.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    118. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell. 2011 Aug 16; 20(2):143-57. Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, Yao Y, Roberts SS, Massimi L, Van Meter T, Weiss WA, Gupta N, Grajkowska W, Lach B, Cho YJ, von Deimling A, Kulozik AE, Witt O, Bader GD, Hawkins CE, Tabori U, Guha A, Rutka JT, Lichter P, Korshunov A, Taylor MD, Pfister SM. PMID: 21840481.
      View in: PubMed   Mentions: 148     Fields:    Translation:Humans
    119. Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol. 2011 Aug; 122(2):231-40. Northcott PA, Hielscher T, Dubuc A, Mack S, Shih D, Remke M, Al-Halabi H, Albrecht S, Jabado N, Eberhart CG, Grajkowska W, Weiss WA, Clifford SC, Bouffet E, Rutka JT, Korshunov A, Pfister S, Taylor MD. PMID: 21681522.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    120. PCDH10 is a candidate tumour suppressor gene in medulloblastoma. Childs Nerv Syst. 2011 Aug; 27(8):1243-9. Bertrand KC, Mack SC, Northcott PA, Garzia L, Dubuc A, Pfister SM, Rutka JT, Weiss WA, Taylor MD. PMID: 21597995.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    121. Autophagy and Akt promote survival in glioma. Autophagy. 2011 May; 7(5):536-8. Fan QW, Weiss WA. PMID: 21266843.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    122. Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms. Cancer Lett. 2011 Jul 28; 306(2):223-9. Mueller S, Yang X, Sottero TL, Gragg A, Prasad G, Polley MY, Weiss WA, Matthay KK, Davidoff AM, DuBois SG, Haas-Kogan DA. PMID: 21497989.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    123. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clin Cancer Res. 2011 Apr 15; 17(8):2339-49. More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. PMID: 21421857.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    124. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 2011 Feb 15; 17(4):654-66. Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. PMID: 21325294.
      View in: PubMed   Mentions: 353     Fields:    Translation:HumansAnimalsCells
    125. Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. Neuro Oncol. 2011 Apr; 13(4):384-92. Prasad G, Sottero T, Yang X, Mueller S, James CD, Weiss WA, Polley MY, Ozawa T, Berger MS, Aftab DT, Prados MD, Haas-Kogan DA. PMID: 21317208.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    126. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. PMID: 21156288.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    127. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010 Nov 09; 3(147):ra81. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. PMID: 21062993.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    128. Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET. Med Phys. 2010 Sep; 37(9):4861-7. Lee CL, Wahnishe H, Sayre GA, Cho HM, Kim HJ, Hernandez-Pampaloni M, Hawkins RA, Dannoon SF, VanBrocklin HF, Itsara M, Weiss WA, Yang X, Haas-Kogan DA, Matthay KK, Seo Y. PMID: 20964203.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    129. Addiction to B-MYB. Oncotarget. 2010 Aug; 1(4):235-6. Gustafson WC, Weiss WA. PMID: 21304174.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    130. Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 2010 May 15; 24(10):1059-72. Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L. PMID: 20478998.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    131. Intratumoral therapy of glioblastoma multiforme using genetically engineered transferrin for drug delivery. Cancer Res. 2010 Jun 01; 70(11):4520-7. Yoon DJ, Kwan BH, Chao FC, Nicolaides TP, Phillips JJ, Lam GY, Mason AB, Weiss WA, Kamei DT. PMID: 20460527.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    132. Myc proteins as therapeutic targets. Oncogene. 2010 Mar 04; 29(9):1249-59. Gustafson WC, Weiss WA. PMID: 20101214.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    133. Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance. Curr Top Microbiol Immunol. 2010; 347:279-96. Fan QW, Weiss WA. PMID: 20535652.
      View in: PubMed   Mentions: 47     Fields:    
    134. A translational end-run for a rare, genetically enigmatic tumor. . 2009 Dec; 8(24):2396-7. Hackett CS, Weiss WA. PMID: 20009571.
      View in: PubMed   Mentions:
    135. Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res. 2009 Nov 01; 69(21):8429-37. Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA, Jenkins RB, Largaespada DA. PMID: 19843846.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    136. Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines. Oncogene. 2009 Sep 03; 28(35):3121-31. Swartling FJ, Ferletta M, Kastemar M, Weiss WA, Westermark B. PMID: 19543319.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    137. Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma. J Cell Physiol. 2009 Jun; 219(3):707-15. Van Maerken T, Sarkar D, Speleman F, Dent P, Weiss WA, Fisher PB. PMID: 19202553.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    138. The side story of stem-like glioma cells. Cell Stem Cell. 2009 Mar 06; 4(3):191-2. Persson AI, Weiss WA. PMID: 19265652.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    139. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009 Jan 27; 2(55):ra4. Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. PMID: 19176518.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    140. PI3K signaling in glioma--animal models and therapeutic challenges. Brain Pathol. 2009 Jan; 19(1):112-20. Cheng CK, Fan QW, Weiss WA. PMID: 19076776.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    141. Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction. Neoplasia. 2008 Nov; 10(11):1268-74. Chesler L, Goldenberg DD, Collins R, Grimmer M, Kim GE, Tihan T, Nguyen K, Yakovenko S, Matthay KK, Weiss WA. PMID: 18953436.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    142. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J. 2008 Oct 01; 415(1):97-110. Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D. PMID: 18498248.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    143. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. . 2008 Sep; 9(9):923-9. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE. PMID: 18660750.
      View in: PubMed   Mentions:
    144. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. PMID: 18577219.
      View in: PubMed   Mentions: 381     Fields:    Translation:HumansAnimalsCells
    145. Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. . 2008 Apr; 7(4):841-50. Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D. PMID: 18413797.
      View in: PubMed   Mentions:
    146. BMPs oppose Math1 in cerebellar development and in medulloblastoma. Genes Dev. 2008 Mar 15; 22(6):693-9. Grimmer MR, Weiss WA. PMID: 18347086.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    147. Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells. J Cell Biochem. 2007 Dec 15; 102(6):1529-41. Meyer GE, Chesler L, Liu D, Gable K, Maddux BA, Goldenberg DD, Youngren JF, Goldfine ID, Weiss WA, Matthay KK, Rosenthal SM. PMID: 17486636.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    148. Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nat Chem Biol. 2007 Dec; 3(12):739-44. Weiss WA, Taylor SS, Shokat KM. PMID: 18007642.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    149. Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. Cancer Res. 2007 Oct 01; 67(19):9435-42. Chesler L, Goldenberg DD, Seales IT, Satchi-Fainaro R, Grimmer M, Collins R, Struett C, Nguyen KN, Kim G, Tihan T, Bao Y, Brekken RA, Bergers G, Folkman J, Weiss WA. PMID: 17909053.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    150. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 2007 Sep 01; 67(17):7960-5. Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. PMID: 17804702.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    151. Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma. Eur J Cancer. 2007 Jun; 43(9):1467-75. Cheng AJ, Cheng NC, Ford J, Smith J, Murray JE, Flemming C, Lastowska M, Jackson MS, Hackett CS, Weiss WA, Marshall GM, Kees UR, Norris MD, Haber M. PMID: 17449239.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    152. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol. 2007 Apr; 3(4):229-38. Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. PMID: 17334377.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    153. Childhood tumors of the nervous system as disorders of normal development. Curr Opin Pediatr. 2006 Dec; 18(6):634-8. Grimmer MR, Weiss WA. PMID: 17099362.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    154. Brain tumors in S100beta-v-erbB transgenic rats. J Neuropathol Exp Neurol. 2006 Dec; 65(12):1111-7. Ohgaki H, Kita D, Favereaux A, Huang H, Homma T, Dessen P, Weiss WA, Kleihues P, Heppner FL. PMID: 17146284.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    155. Genotype-phenotype correlations in tuberous sclerosis: who and how to treat. Ann Neurol. 2006 Nov; 60(5):505-7. Goh S, Weiss WA. PMID: 17120247.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    156. Isoform specific inhibitors of PI3 kinase in glioma. . 2006 Oct; 5(20):2301-5. Fan QW, Weiss WA. PMID: 17102612.
      View in: PubMed   Mentions:
    157. Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma. Cancer Res. 2006 Aug 15; 66(16):8139-46. Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, Matthay KK, Rowitch D, Weiss WA. PMID: 16912192.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    158. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May; 9(5):341-9. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. PMID: 16697955.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimalsCells
    159. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19; 125(4):733-47. Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. PMID: 16647110.
      View in: PubMed   Mentions: 398     Fields:    Translation:HumansAnimalsCells
    160. Chemical genetic approaches to the development of cancer therapeutics. Curr Opin Genet Dev. 2006 Feb; 16(1):85-91. Fan QW, Weiss WA. PMID: 16359858.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    161. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 2005 Jun; 37(6):645-51. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. PMID: 15895082.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    162. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005 May 01; 65(9):3617-23. Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF. PMID: 15867356.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    163. RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene. 2005 Jan 27; 24(5):829-37. Fan QW, Weiss WA. PMID: 15580296.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    164. Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12664-9. Hansford LM, Thomas WD, Keating JM, Burkhart CA, Peaston AE, Norris MD, Haber M, Armati PJ, Weiss WA, Marshall GM. PMID: 15314226.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    165. Can mouse models for brain tumors inform treatment in pediatric patients? Semin Cancer Biol. 2004 Feb; 14(1):71-7. Weiss WA, Banerjee A. PMID: 14757537.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    166. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res. 2003 Dec 15; 63(24):8930-8. Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. PMID: 14695210.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    167. Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma. J Natl Cancer Inst. 2003 Sep 17; 95(18):1394-403. Burkhart CA, Cheng AJ, Madafiglio J, Kavallaris M, Mili M, Marshall GM, Weiss WA, Khachigian LM, Norris MD, Haber M. PMID: 13130115.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    168. Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors. Cancer Res. 2003 Sep 01; 63(17):5266-73. Hackett CS, Hodgson JG, Law ME, Fridlyand J, Osoegawa K, de Jong PJ, Nowak NJ, Pinkel D, Albertson DG, Jain A, Jenkins R, Gray JW, Weiss WA. PMID: 14500357.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    169. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 2003 Apr 01; 63(7):1589-95. Weiss WA, Burns MJ, Hackett C, Aldape K, Hill JR, Kuriyama H, Kuriyama N, Milshteyn N, Roberts T, Wendland MF, DePinho R, Israel MA. PMID: 12670909.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    170. Targeted therapy of brain tumors utilizing neural stem and progenitor cells. Front Biosci. 2003 Jan 01; 8:e228-34. Burns MJ, Weiss W. PMID: 12456351.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    171. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene. 2002 Oct 24; 21(49):7453-63. Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey AI, Roberts T, Van Dyke T, Wetmore C, Chiu IM, Giovannini M, Guha A, Higgins RJ, Marino S, Radovanovic I, Reilly K, Aldape K. PMID: 12386807.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    172. Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Curr Biol. 2002 Aug 20; 12(16):1386-94. Fan QW, Zhang C, Shokat KM, Weiss WA. PMID: 12194819.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    173. A head holder for magnetic resonance imaging that allows the stereotaxic alignment of spontaneously occurring intracranial mouse tumors. J Neurosci Methods. 2002 Apr 30; 116(1):1-7. Tada T, Wendland M, Watson N, Kuriyama N, Kuriyama H, Roberts T, Burns M, Weiss W, Israel MA. PMID: 12007978.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    174. Genetics of brain tumors. Curr Opin Pediatr. 2000 Dec; 12(6):543-8. Weiss WA. PMID: 11106272.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    175. Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma. Cancer Res. 2000 May 01; 60(9):2483-7. Weiss WA, Godfrey T, Francisco C, Bishop JM. PMID: 10811128.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    176. Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 1997 Jun 02; 16(11):2985-95. Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM. PMID: 9214616.
      View in: PubMed   Mentions: 253     Fields:    Translation:AnimalsCells
    William A.'s Networks
    Concepts (709)
    Derived automatically from this person's publications.
    _
    Co-Authors (120)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _