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Daniel Lim, MD, PhD

Title(s)Associate Professor, Neurological Surgery
SchoolSchool of Medicine
Phone415-476-8138
ORCID ORCID Icon0000-0001-7221-3425 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.A.1994MCB
    Rockefeller UniversityPh.D.2001
    Cornell Medical SchoolM.D.2002
    University of California, San FranciscoResidency2008Neurological Surgery
    Collapse Awards and Honors
    National Institutes of Health2009  - 2014NIH Director's New Innovator Award
    Sontag Foundation2009  - 2013Distinguished Researcher Award
    U.S. National Academy of Sciences2010Kavli Fellow

    Collapse Research 
    Collapse Research Activities and Funding
    Functional long noncoding RNAs in human glioma
    NIH/NINDS R21NS101395Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Long noncoding RNA regulation of neural stem cells
    NIH/NINDS R01NS091544Feb 15, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Chromatin-based regulation of neural stem cells
    VA I01BX000252Oct 1, 2009 - Sep 30, 2022
    Role: Principal Investigator
    Chromatin-based cellular memory in neural stem cells
    NIH DP2OD006505Sep 30, 2009 - Jun 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA. Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1. Science. 2020 Apr 03; 368(6486):48-53. PMID: 32241942.
      View in: PubMed
    2. Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, Lim DA. CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. Genome Biol. 2020 Mar 31; 21(1):83. PMID: 32234056.
      View in: PubMed
    3. Chen W, de Hemptinne C, Miller AM, Leibbrand M, Little SJ, Lim DA, Larson PS, Starr PA. Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans. Neuron. 2020 Feb 26. PMID: 32155442.
      View in: PubMed
    4. Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS. Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Nat Biotechnol. 2020 Feb 24. PMID: 32094656.
      View in: PubMed
    5. Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 Jan 02; 26(1):48-63.e6. PMID: 31901251.
      View in: PubMed
    6. S John Liu, Martina Malatesta, Kyounghee Seo, Brian Lien, Sung Hong, Mark Koontz, David Raleigh, Erik Ullian, Daniel Lim. GENE-39. CRISPRi-BASED RADIATION MODIFIER SCREEN IDENTIFIES LONG NON-CODING RNA THERAPEUTIC TARGETS IN GLIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi106-vi106.
      View in: Publisher Site
    7. S John Liu, Harish Vasudevan, Melike Pekmezci, Abrar Choudhury, Brian Lien, Jonathan Breshears, Danielle Swaney, Stephen Magill, Ursula Lang, William Chen, Chetna Gopinath, Maria Castro, Javier Villanueva-Meyer, Steve Braunstein, Patricia Sneed, Daniel Lim, Arie Perry, Nevan Krogran, Mike McDermott, Mitchel Berger, Philip Theodosopoulos, David Raleigh. GENE-37. VESTIBULAR SCHWANNOMA IS COMPRISED OF NEURAL CREST AND IMMUNE SUBGROUPS. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi105-vi105.
      View in: Publisher Site
    8. Stephen Magill, Harish Vasudevan, Kyounghee Seo, S John Liu, Stephanie Hilz, Javier Villanueva-Meyer, Abrar Choudhury, Benjamin Demaree, Daniel Lim, Steve Braunstein, Nancy Ann Oberheim-Bush, Erik Ullian, Manish Aghi, Philip Theodosopoulos, Patricia Sneed, Adam Abate, Mitchel Berger, Mike McDermott, Joseph Costello, David Raleigh. TMOD-27. A NEURAL CREST CELL SUBPOPULATION UNDERLIES INTRATUMOR HETEROGENEITY IN MENINGIOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi268-vi268.
      View in: Publisher Site
    9. Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH. Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease. Stem Cell Reports. 2019 08 13; 13(2):254-261. PMID: 31378671.
      View in: PubMed
    10. Andersen RE, Hong SJ, Lim JJ, Cui M, Harpur BA, Hwang E, Delgado RN, Ramos AD, Liu SJ, Blencowe BJ, Lim DA. The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo. Dev Cell. 2019 05 20; 49(4):632-642.e7. PMID: 31112699.
      View in: PubMed
    11. Ethan A. Winkler, Daniel A. Lim. Chapter 17 Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices. Nervous System Drug Delivery. 2019 Jan 1; 351-364.
      View in: Publisher Site
    12. Liu SJ, Lim DA. Modulating the expression of long non-coding RNAs for functional studies. EMBO Rep. 2018 12; 19(12). PMID: 30467236.
      View in: PubMed
    13. Soeren Mueller, Aparna Bhaduri, Elizabeth DiLullo, Garima Yagnik, Daniel Lim, Manish Aghi, Arnold Kriegstein, Aaron Diaz. STEM-06. A DRAFT SINGLE-CELL ATLAS OF HUMAN GLIOBLASTOMA REVEALS SPATIAL AND DIFFERENTIATION GRADIENTS OF STEM-LIKE CELLS. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi244-vi245.
      View in: Publisher Site
    14. Martina Malatesta, John Liu, Leslie Pedraza, Kyounghee Seo, Elizabeth DiLullo, David Raleigh, Arnold Kriegstein, Erik Ullian, Daniel Lim. TMOD-04. TARGETING A GLIOMA SPECIFIC lncRNA IN A HUMAN BRAIN ORGANOID TUMOR MODEL. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi269-vi269.
      View in: Publisher Site
    15. Müller S, Cho A, Liu SJ, Lim DA, Diaz A. CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones. Bioinformatics. 2018 09 15; 34(18):3217-3219. PMID: 29897414.
      View in: PubMed
    16. Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018 05 31; 173(6):1398-1412.e22. PMID: 29731168.
      View in: PubMed
    17. Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A. Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment. Genome Biol. 2017 Dec 20; 18(1):234. PMID: 29262845.
      View in: PubMed
    18. Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein AR. Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex. Science. 2017 12 08; 358(6368):1318-1323. PMID: 29217575.
      View in: PubMed
    19. Delgado RN, Lim DA. Maintenance of Positional Identity of Neural Progenitors in the Embryonic and Postnatal Telencephalon. Front Mol Neurosci. 2017; 10:373. PMID: 29180952.
      View in: PubMed
    20. Soeren Mueller, Daniel He, Josie Hayes, Siyuan Liu, Martina Malatesta, Arnold Kriegstein, Manish Aghi, Daniel Lim, Aaron Diaz. GENE-06. EXPRESSION OF LINC00152, A PUTATIVE SPONGE FOR TUMOR-SUPPRESSIVE micro-RNA, CORRELATES WITH GLIOMA GRADE. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi93-vi93.
      View in: Publisher Site
    21. Andersen RE, Lim DA. Forging our understanding of lncRNAs in the brain. Cell Tissue Res. 2018 01; 371(1):55-71. PMID: 29079882.
      View in: PubMed
    22. Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM. Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells. Stem Cell Reports. 2017 07 11; 9(1):203-216. PMID: 28648897.
      View in: PubMed
    23. Rolston JD, Lim DA. In Reply: Thalamotomy-Like Effects from Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor. Neurosurgery. 2017 05 01; 80(5):E256. PMID: 28368504.
      View in: PubMed
    24. I. Slavc, J. Cohen-Pfeffer, S. Gururangan, E. Jurecki, J. Krauser, T. Lester, D. Lim, M. Maldaun, C. Schwering, A. Shaywitz, M. Westphal. Expert Opinion on the Management of Intracerebroventricular (ICV) Drug Delivery. Neuropediatrics. 2017 Apr 26; 48(S 01):s1-s45.
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    25. Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320). PMID: 27980086.
      View in: PubMed
    26. Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25; 12(11):889. PMID: 27888226.
      View in: PubMed
    27. Soren Muller, Siyuan Liu, Martina Malatesta, Manish Aghi, Arnold Kriegstein, Gary Kohanbash, Daniel Lim, Aaron Diaz. GENT-22. SINGLE-CELL PROFILING OF GLIOBLASTOMA BIOPSIES IDENTIFIES A FAMILY OF ACTIVATING PDGF-RECEPTOR DELETIONS. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi78-vi78.
      View in: Publisher Site
    28. Siyuan Liu, Max Horlbeck, Seung Woo Cho, Harjus Birk, Martina Malatesta, Daniel He, Jacqueline Villalta, Min Cho, Yuwen Chen, Mohammad Mandegar, Michael Olvera, Bruce Conklin, Howard Chang, Jonathan Weissman, Daniel Lim. GENT-49. SYSTEMATIC IDENTIFICATION OF ESSENTIAL LONG NON-CODING RNA GENES IN GLIOBLASTOMA. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi84-vi85.
      View in: Publisher Site
    29. Delgado RN, Lu C, Lim DA. Maintenance of neural stem cell regional identity in culture. Neurogenesis (Austin). 2016; 3(1):e1187321. PMID: 27606338.
      View in: PubMed
    30. Lim DA, Alvarez-Buylla A. The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis. Cold Spring Harb Perspect Biol. 2016 May 02; 8(5). PMID: 27048191.
      View in: PubMed
    31. Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A. SCell: integrated analysis of single-cell RNA-seq data. Bioinformatics. 2016 07 15; 32(14):2219-20. PMID: 27153637.
      View in: PubMed
    32. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016 Apr 14; 17:67. PMID: 27081004.
      View in: PubMed
    33. Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim DA, Bankiewicz KS. Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease. Mol Ther Methods Clin Dev. 2016; 3:15051. PMID: 26817024.
      View in: PubMed
    34. Ramos AD, Attenello FJ, Lim DA. Uncovering the roles of long noncoding RNAs in neural development and glioma progression. Neurosci Lett. 2016 06 20; 625:70-9. PMID: 26733304.
      View in: PubMed
    35. Rolston JD, Ramos AD, Heath S, Englot DJ, Lim DA. Thalamotomy-Like Effects From Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor: Case Report. Neurosurgery. 2015 Nov; 77(5):E831-6; discussion E836-7. PMID: 26200771.
      View in: PubMed
    36. Frank Attenello, S. John Liu, Martina Malatesta, Hosniya Zarabi, Rebecca Andersen, Alexander Ramos, Daniel Lim. GENO-04REGULATION OF GLIOBLASTOMA BY NOVEL LONG NONCODING RNA (lncRNA). Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v91-v92.
      View in: Publisher Site
    37. John Liu, Elizabeth Di Lullo, Martina Malatesta, Gary Kohanbash, Brandyn Castro, Hideho Okada, Arnold Kriegstein, Manish Aghi, Daniel Lim, Aaron Diaz. GENO-14SINGLE-CELL TRANSCIPTOMICS AND GENOMICS REVEALS A DIVERSITY OF TUMOR AND IMMUNE CELL POLARIZATION SIGNALS IN GBM. Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v94-v94.
      View in: Publisher Site
    38. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR. Molecular identity of human outer radial glia during cortical development. Cell. 2015 Sep 24; 163(1):55-67. PMID: 26406371.
      View in: PubMed
    39. Delgado RN, Lim DA. Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells. Dev Biol. 2015 Nov 15; 407(2):265-74. PMID: 26387477.
      View in: PubMed
    40. Lim DA. Transcriptional and epigenetic insights from stem cells and developing tissues. Development. 2015 Aug 01; 142(15):2549-53. PMID: 26243867.
      View in: PubMed
    41. Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz C, Salinas RD, Zarabi H, Kriegstein AR, Lim DA. The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell. 2015 Apr 02; 16(4):439-447. PMID: 25800779.
      View in: PubMed
    42. Rowland NC, Starr PA, Larson PS, Ostrem JL, Marks WJ, Lim DA. Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease. Mov Disord. 2015 Feb; 30(2):190-5. PMID: 25521796.
      View in: PubMed
    43. Ryan Salinas, John Liu, Ryan Delgado, Ki Youb Park, James Price, Alex Ramos, Joanna Phillips, Daniel Lim. EG-14EPIGENETIC DYSREGULATION OF THE HoxA LOCUS AND OTHER HOMEOBOX GENES DRIVEN BY Ink4a/arf DEFICIENCY AND EGFRviii. Neuro-Oncology. 2014 Nov 1; 16(suppl_5):v78-v78.
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    44. Potts MB, Siu JJ, Price JD, Salinas RD, Cho MJ, Ramos AD, Hahn J, Margeta M, Oldham MC, Lim DA. Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming. Neurosurgery. 2014 Oct; 75(4):472-82; discussion 482. PMID: 24887289.
      View in: PubMed
    45. Lim DA, Alvarez-Buylla A. Adult neural stem cells stake their ground. Trends Neurosci. 2014 Oct; 37(10):563-71. PMID: 25223700.
      View in: PubMed
    46. Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein AR, Lim DA. The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation. J Neurosci. 2014 Sep 10; 34(37):12560-7. PMID: 25209293.
      View in: PubMed
    47. Park DH, Hong SJ, Salinas RD, Liu SJ, Sun SW, Sgualdino J, Testa G, Matzuk MM, Iwamori N, Lim DA. Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis. Cell Rep. 2014 Sep 11; 8(5):1290-9. PMID: 25176653.
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    48. Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim DA. Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment. Mol Ther. 2015 Jan; 23(1):119-29. PMID: 25138755.
      View in: PubMed
    49. Andersen RE, Lim DA. An ingredient for the elixir of youth. Cell Res. 2014 Dec; 24(12):1381-2. PMID: 25112712.
      View in: PubMed
    50. Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL. Stem cell epigenetics: looking forward. Cell Stem Cell. 2014 Jun 05; 14(6):706-9. PMID: 25032261.
      View in: PubMed
    51. Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA. Distinct and separable roles for EZH2 in neurogenic astroglia. Elife. 2014 May 27; 3:e02439. PMID: 24867641.
      View in: PubMed
    52. Cheng JS, Lim DA, Chang EF, Barbaro NM. A review of percutaneous treatments for trigeminal neuralgia. Neurosurgery. 2014 Mar; 10 Suppl 1:25-33; discussion 33. PMID: 24509496.
      View in: PubMed
    53. Gonzales-Roybal G, Lim DA. Chromatin-based epigenetics of adult subventricular zone neural stem cells. Front Genet. 2013 Oct 08; 4:194. PMID: 24115953.
      View in: PubMed
    54. Cheng JS, Lim DA, Chang EF, Barbaro NM. A Review of Percutaneous Treatments for Trigeminal Neuralgia. Neurosurgery. 2013 Sep 23. PMID: 24064481.
      View in: PubMed
    55. Ramos AD, Diaz A, Nellore A, Delgado RN, Park KY, Gonzales-Roybal G, Oldham MC, Song JS, Lim DA. Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo. Cell Stem Cell. 2013 May 02; 12(5):616-28. PMID: 23583100.
      View in: PubMed
    56. Potts MB, Silvestrini MT, Lim DA. Devices for cell transplantation into the central nervous system: Design considerations and emerging technologies. Surg Neurol Int. 2013; 4(Suppl 1):S22-30. PMID: 23653887.
      View in: PubMed
    57. Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013; 91(2):92-103. PMID: 23343609.
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    58. Lim DA, Chan MF, Childs C. Surrogate consent for critical care research: exploratory study on public perception and influences on recruitment. Crit Care. 2013 Jan 15; 17(1):R5. PMID: 23320945.
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    59. Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10; 4(155):155ra137. PMID: 23052294.
      View in: PubMed
    60. Potts MB, Lim DA. An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation. Cell Stem Cell. 2012 Jul 06; 11(1):5-6. PMID: 22770236.
      View in: PubMed
    61. Diaz A, Park K, Lim DA, Song JS. Normalization, bias correction, and peak calling for ChIP-seq. Stat Appl Genet Mol Biol. 2012 Mar 31; 11(3):Article 9. PMID: 22499706.
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    62. Crowell AL, Ryapolova-Webb ES, Ostrem JL, Galifianakis NB, Shimamoto S, Lim DA, Starr PA. Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study. Brain. 2012 Feb; 135(Pt 2):615-30. PMID: 22252995.
      View in: PubMed
    63. William W. Hwang, Arturo Alvarez-Buylla, Daniel A. Lim. Glial Nature of Adult Neural Stem Cells: Neurogenic Competence in Adult Astrocytes. Neural Development and Stem Cells. 2012 Jan 1; 149-172.
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    64. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. PMID: 21907924.
      View in: PubMed
    65. Johnston MA, Lim DA. Keeping them quiet: BMPs maintain adult neural stem cell quiescence. Cell Stem Cell. 2010 Jul 02; 7(1):9-10. PMID: 20621042.
      View in: PubMed
    66. Oh MC, Lim DA. Novel treatment strategies for malignant gliomas using neural stem cells. Neurotherapeutics. 2009 Jul; 6(3):458-64. PMID: 19560736.
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    67. Roskom J, Swistowski A, Zeng X, Lim DA. Future directions: use of interventional MRI for cell-based therapy of Parkinson disease. Neurosurg Clin N Am. 2009 Apr; 20(2):211-8. PMID: 19555884.
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    68. Lim DA, Larson PS. Intraoperative MRI in functional neurosurgery. Preface. Neurosurg Clin N Am. 2009 Apr; 20(2):xi. PMID: 19555874.
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    69. Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. 2009 Mar 26; 458(7237):529-33. PMID: 19212323.
      View in: PubMed
    70. Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, Chang S, Lamborn KR, McDermott MW. Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. J Neurooncol. 2009 Jul; 93(3):349-54. PMID: 19169651.
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    71. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. PMID: 18577219.
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    72. Daniel A. Lim, Michael Sughrue, Michael W. McDermott. Chapter 1 Structure and Function of the Brain and Spinal Cord. Essentials of Neuroanesthesia and Neurointensive Care. 2008 Jan 1; 3-12.
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    73. Daniel C. Lu, Daniel A. Lim, Dean Chou. Lumbar Spine Coccidioidomycosis Osteomyelitis Requiring Lumbo-Pelvic Reconstruction. Neurosurgery Quarterly. 2007 Sep 1; 17(3):156-160.
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    74. Lim DA, Cha S, Mayo MC, Chen MH, Keles E, VandenBerg S, Berger MS. Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neuro Oncol. 2007 Oct; 9(4):424-9. PMID: 17622647.
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    75. Lim DA, Khandhar SM, Heath S, Ostrem JL, Ringel N, Starr P. Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor. Stereotact Funct Neurosurg. 2007; 85(4):144-9. PMID: 17259750.
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    76. Lim DA, Huang YC, Alvarez-Buylla A. The adult neural stem cell niche: lessons for future neural cell replacement strategies. Neurosurg Clin N Am. 2007 Jan; 18(1):81-92, ix. PMID: 17244556.
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    77. Lim DA, Suárez-Fariñas M, Naef F, Hacker CR, Menn B, Takebayashi H, Magnasco M, Patil N, Alvarez-Buylla A. In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis. Mol Cell Neurosci. 2006 Jan; 31(1):131-48. PMID: 16330219.
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    78. Palma V, Lim DA, Dahmane N, Sánchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A, Ruiz i Altaba A. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development. 2005 Jan; 132(2):335-44. PMID: 15604099.
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    79. Alvarez-Buylla A, Lim DA. For the long run: maintaining germinal niches in the adult brain. Neuron. 2004 Mar 04; 41(5):683-6. PMID: 15003168.
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    80. Caporaso GL, Lim DA, Alvarez-Buylla A, Chao MV. Telomerase activity in the subventricular zone of adult mice. Mol Cell Neurosci. 2003 Aug; 23(4):693-702. PMID: 12932448.
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    81. Tramontin AD, García-Verdugo JM, Lim DA, Alvarez-Buylla A. Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment. Cereb Cortex. 2003 Jun; 13(6):580-7. PMID: 12764031.
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    82. Naef F, Lim DA, Patil N, Magnasco M. DNA hybridization to mismatched templates: a chip study. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Apr; 65(4 Pt 1):040902. PMID: 12005798.
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    83. Lim DA, Flames N, Collado L, Herrera DG. Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies. Brain Res Bull. 2002 Apr; 57(6):759-64. PMID: 12031272.
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    84. Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL. A Ca(2+) switch aligns the active site of calpain. Cell. 2002 Mar 08; 108(5):649-60. PMID: 11893336.
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    85. Gritti A, Bonfanti L, Doetsch F, Caille I, Alvarez-Buylla A, Lim DA, Galli R, Verdugo JM, Herrera DG, Vescovi AL. Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents. J Neurosci. 2002 Jan 15; 22(2):437-45. PMID: 11784788.
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    86. Lim DA, Tramontin AD, Trevejo JM, Herrera DG, García-Verdugo JM, Alvarez-Buylla A. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron. 2000 Dec; 28(3):713-26. PMID: 11163261.
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    87. Li XC, Jarvis ED, Alvarez-Borda B, Lim DA, Nottebohm F. A relationship between behavior, neurotrophin expression, and new neuron survival. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8584-9. PMID: 10890902.
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    88. Lim DA, Alvarez-Buylla A. Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7526-31. PMID: 10377448.
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    89. Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 1999 Jun 11; 97(6):703-16. PMID: 10380923.
      View in: PubMed
    90. García-Verdugo JM, Doetsch F, Wichterle H, Lim DA, Alvarez-Buylla A. Architecture and cell types of the adult subventricular zone: in search of the stem cells. J Neurobiol. 1998 Aug; 36(2):234-48. PMID: 9712307.
      View in: PubMed
    91. Lim DA, Gossen M, Lehman CW, Botchan MR. Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control. J Virol. 1998 Mar; 72(3):1931-40. PMID: 9499046.
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    92. Lim DA, Fishell GJ, Alvarez-Buylla A. Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14832-6. PMID: 9405699.
      View in: PubMed
    93. Thorner LK, Lim DA, Botchan MR. DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects. J Virol. 1993 Oct; 67(10):6000-14. PMID: 8396665.
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    94. Yang L, Mohr I, Fouts E, Lim DA, Nohaile M, Botchan M. The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5086-90. PMID: 8389467.
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