Loading...

Daniel Lim, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentNeurological Surgery
Address35 Medical Center way
San Fancisco CA 94143
Phone415-476-8138
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.A.1994MCB
    Rockefeller UniversityPh.D.2001
    Cornell Medical SchoolM.D.2002
    University of California, San FranciscoResidency2008Neurological Surgery
    Collapse Awards and Honors
    National Institutes of Health2009  - 2014NIH Director's New Innovator Award
    Sontag Foundation2009  - 2013Distinguished Researcher Award
    U.S. National Academy of Sciences2010Kavli Fellow

    Collapse Research 
    Collapse Research Activities and Funding
    Functional long noncoding RNAs in human glioma
    NIH/NINDS R21NS101395Apr 1, 2017 - Mar 31, 2019
    Role: Principal Investigator
    Long noncoding RNA regulation of neural stem cells
    NIH/NINDS R01NS091544Feb 15, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Chromatin-based cellular memory in neural stem cells
    NIH DP2OD006505Sep 30, 2009 - Jun 30, 2014
    Role: Principal Investigator
    Role of MLL1 chromatin remodeling factor in neural stem cells
    VA I01BX000252Apr 1, 2009 - Mar 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim D. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2016 Dec 15. PMID: 27980086.
      View in: PubMed
    2. Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim D, Diaz A. Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas. Mol Syst Biol. 2016 Nov 25; 12(11):889. PMID: 27888226.
      View in: PubMed
    3. Delgado RN, Lu C, Lim D. Maintenance of neural stem cell regional identity in culture. Neurogenesis (Austin). 2016; 3(1):e1187321. PMID: 27606338; PMCID: PMC4973606 [Available on 05/09/17].
      View in: PubMed, PubMed Central
    4. Lim D, Alvarez-Buylla A. The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis. Cold Spring Harb Perspect Biol. 2016; 8(5). PMID: 27048191.
      View in: PubMed
    5. Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim D, Kriegstein A. SCell: integrated analysis of single-cell RNA-seq data. Bioinformatics. 2016 Jul 15; 32(14):2219-20. PMID: 27153637.
      View in: PubMed
    6. Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim D. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 2016; 17(1):67. PMID: 27081004.
      View in: PubMed
    7. Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim D, Bankiewicz KS. Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease. Mol Ther Methods Clin Dev. 2016; 3:15051. PMID: 26817024.
      View in: PubMed
    8. Ramos AD, Attenello FJ, Lim D. Uncovering the roles of long noncoding RNAs in neural development and glioma progression. Neurosci Lett. 2016 Jun 20; 625:70-9. PMID: 26733304.
      View in: PubMed
    9. Rolston JD, Ramos AD, Heath S, Englot DJ, Lim D. Thalamotomy-Like Effects From Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor: Case Report. Neurosurgery. 2015 Nov; 77(5):E831-7. PMID: 26200771.
      View in: PubMed
    10. Delgado RN, Lim D. Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells. Dev Biol. 2015 Nov 15; 407(2):265-74. PMID: 26387477; PMCID: PMC4663161 [Available on 11/15/16].
      View in: PubMed, PubMed Central
    11. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim D, Leyrat AA, West JA, Kriegstein AR. Molecular Identity of Human Outer Radial Glia during Cortical Development. Cell. 2015 Sep 24; 163(1):55-67. PMID: 26406371; PMCID: PMC4583716 [Available on 09/24/16].
      View in: PubMed, PubMed Central
    12. Lim D. Transcriptional and epigenetic insights from stem cells and developing tissues. Development. 2015 Aug 1; 142(15):2549-53. PMID: 26243867.
      View in: PubMed
    13. Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz CC, Salinas RD, Zarabi H, Kriegstein AR, Lim D. The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells. Cell Stem Cell. 2015 Apr 2; 16(4):439-47. PMID: 25800779; PMCID: PMC4388801 [Available on 04/02/16].
      View in: PubMed, PubMed Central
    14. Rowland NC, Starr PA, Larson PS, Ostrem JL, Marks WJ, Lim D. Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease. Mov Disord. 2015 Feb; 30(2):190-5. PMID: 25521796.
      View in: PubMed
    15. Potts MB, Siu JJ, Price JD, Salinas RD, Cho MJ, Ramos AD, Hahn J, Margeta M, Oldham MC, Lim D. Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming. Neurosurgery. 2014 Oct; 75(4):472-82; discussion 482. PMID: 24887289; PMCID: PMC4420187.
      View in: PubMed, PubMed Central
    16. Lim D, Alvarez-Buylla A. Adult neural stem cells stake their ground. Trends Neurosci. 2014 Oct; 37(10):563-71. PMID: 25223700; PMCID: PMC4203324.
      View in: PubMed, PubMed Central
    17. Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein AR, Lim D. The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation. J Neurosci. 2014 Sep 10; 34(37):12560-7. PMID: 25209293; PMCID: PMC4160784.
      View in: PubMed, PubMed Central
    18. Park DH, Hong SJ, Salinas RD, Liu SJ, Sun SW, Sgualdino J, Testa G, Matzuk MM, Iwamori N, Lim D. Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis. Cell Rep. 2014 Sep 11; 8(5):1290-9. PMID: 25176653; PMCID: PMC4201382.
      View in: PubMed, PubMed Central
    19. Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim D. Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment. Mol Ther. 2015 Jan; 23(1):119-29. PMID: 25138755; PMCID: PMC4426791 [Available on 01/01/16].
      View in: PubMed, PubMed Central
    20. Andersen RE, Lim D. An ingredient for the elixir of youth. Cell Res. 2014 Dec; 24(12):1381-2. PMID: 25112712; PMCID: PMC4260342 [Available on 12/01/15].
      View in: PubMed, PubMed Central
    21. Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim D, Meshorer E, Pombo A, Sander M, Xu GL. Stem cell epigenetics: looking forward. Cell Stem Cell. 2014 Jun 5; 14(6):706-9. PMID: 25032261.
      View in: PubMed
    22. Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim D. Distinct and separable roles for EZH2 in neurogenic astroglia. Elife. 2014; 3:e02439. PMID: 24867641; PMCID: PMC4032491.
      View in: PubMed, PubMed Central
    23. Cheng JS, Lim D, Chang EF, Barbaro NM. A review of percutaneous treatments for trigeminal neuralgia. Neurosurgery. 2014 Mar; 10 Suppl 1:25-33; discussion 33. PMID: 24509496.
      View in: PubMed
    24. Gonzales-Roybal G, Lim D. Chromatin-based epigenetics of adult subventricular zone neural stem cells. Front Genet. 2013; 4:194. PMID: 24115953; PMCID: PMC3792351.
      View in: PubMed, PubMed Central
    25. Cheng JS, Lim D, Chang EF, Barbaro NM. A Review of Percutaneous Treatments for Trigeminal Neuralgia. Neurosurgery. 2013 Sep 23. PMID: 24064481.
      View in: PubMed
    26. Ramos AD, Diaz A, Nellore A, Delgado RN, Park KY, Gonzales-Roybal G, Oldham MC, Song JS, Lim D. Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo. Cell Stem Cell. 2013 May 2; 12(5):616-28. PMID: 23583100; PMCID: PMC3662805.
      View in: PubMed, PubMed Central
    27. Potts MB, Silvestrini MT, Lim D. Devices for cell transplantation into the central nervous system: Design considerations and emerging technologies. Surg Neurol Int. 2013; 4(Suppl 1):S22-30. PMID: 23653887; PMCID: PMC3642746.
      View in: PubMed, PubMed Central
    28. Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim D. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013; 91(2):92-103. PMID: 23343609; PMCID: PMC3739996.
      View in: PubMed, PubMed Central
    29. Lim D, Chan MF, Childs C. Surrogate consent for critical care research: exploratory study on public perception and influences on recruitment. Crit Care. 2013; 17(1):R5. PMID: 23320945; PMCID: PMC4057109.
      View in: PubMed, PubMed Central
    30. Gupta N, Henry RG, Strober J, Kang SM, Lim D, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10; 4(155):155ra137. PMID: 23052294; PMCID: PMC3893824.
      View in: PubMed, PubMed Central
    31. Potts MB, Lim D. An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation. Cell Stem Cell. 2012 Jul 6; 11(1):5-6. PMID: 22770236; PMCID: PMC3468946.
      View in: PubMed, PubMed Central
    32. Diaz A, Park K, Lim D, Song JS. Normalization, bias correction, and peak calling for ChIP-seq. Stat Appl Genet Mol Biol. 2012; 11(3):Article 9. PMID: 22499706; PMCID: PMC3342857.
      View in: PubMed, PubMed Central
    33. Crowell AL, Ryapolova-Webb ES, Ostrem JL, Galifianakis NB, Shimamoto S, Lim D, Starr PA. Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study. Brain. 2012 Feb; 135(Pt 2):615-30. PMID: 22252995; PMCID: PMC3281473.
      View in: PubMed, PubMed Central
    34. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim D, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40. PMID: 21907924; PMCID: PMC3297490.
      View in: PubMed, PubMed Central
    35. Johnston MA, Lim D. Keeping them quiet: BMPs maintain adult neural stem cell quiescence. Cell Stem Cell. 2010 Jul 2; 7(1):9-10. PMID: 20621042.
      View in: PubMed
    36. Oh MC, Lim D. Novel treatment strategies for malignant gliomas using neural stem cells. Neurotherapeutics. 2009 Jul; 6(3):458-64. PMID: 19560736.
      View in: PubMed
    37. Lim D, Larson PS. Intraoperative MRI in functional neurosurgery. Preface. Neurosurg Clin N Am. 2009 Apr; 20(2):xi. PMID: 19555874.
      View in: PubMed
    38. Roskom J, Swistowski A, Zeng X, Lim D. Future directions: use of interventional MRI for cell-based therapy of Parkinson disease. Neurosurg Clin N Am. 2009 Apr; 20(2):211-8. PMID: 19555884.
      View in: PubMed
    39. Lim D, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. 2009 Mar 26; 458(7237):529-33. PMID: 19212323; PMCID: PMC3800116.
      View in: PubMed, PubMed Central
    40. Lim D, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, Chang S, Lamborn KR, McDermott MW. Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. J Neurooncol. 2009 Jul; 93(3):349-54. PMID: 19169651; PMCID: PMC2687520.
      View in: PubMed, PubMed Central
    41. Silber J, Lim D, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14. PMID: 18577219; PMCID: PMC2443372.
      View in: PubMed, PubMed Central
    42. Lim D, Cha S, Mayo MC, Chen MH, Keles E, VandenBerg S, Berger MS. Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neuro Oncol. 2007 Oct; 9(4):424-9. PMID: 17622647; PMCID: PMC1994099.
      View in: PubMed, PubMed Central
    43. Lim D, Khandhar SM, Heath S, Ostrem JL, Ringel N, Starr P. Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor. Stereotact Funct Neurosurg. 2007; 85(4):144-9. PMID: 17259750.
      View in: PubMed
    44. Lim D, Huang YC, Alvarez-Buylla A. The adult neural stem cell niche: lessons for future neural cell replacement strategies. Neurosurg Clin N Am. 2007 Jan; 18(1):81-92, ix. PMID: 17244556.
      View in: PubMed
    45. Lim D, Suárez-Fariñas M, Naef F, Hacker CR, Menn B, Takebayashi H, Magnasco M, Patil N, Alvarez-Buylla A. In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis. Mol Cell Neurosci. 2006 Jan; 31(1):131-48. PMID: 16330219.
      View in: PubMed
    46. Palma V, Lim D, Dahmane N, Sánchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A, Ruiz i Altaba A. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development. 2005 Jan; 132(2):335-44. PMID: 15604099; PMCID: PMC1431583.
      View in: PubMed, PubMed Central
    47. Alvarez-Buylla A, Lim D. For the long run: maintaining germinal niches in the adult brain. Neuron. 2004 Mar 4; 41(5):683-6. PMID: 15003168.
      View in: PubMed
    48. Caporaso GL, Lim D, Alvarez-Buylla A, Chao MV. Telomerase activity in the subventricular zone of adult mice. Mol Cell Neurosci. 2003 Aug; 23(4):693-702. PMID: 12932448.
      View in: PubMed
    49. Tramontin AD, García-Verdugo JM, Lim D, Alvarez-Buylla A. Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment. Cereb Cortex. 2003 Jun; 13(6):580-7. PMID: 12764031.
      View in: PubMed
    50. Naef F, Lim D, Patil N, Magnasco M. DNA hybridization to mismatched templates: a chip study. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Apr; 65(4 Pt 1):040902. PMID: 12005798.
      View in: PubMed
    51. Lim D, Flames N, Collado L, Herrera DG. Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies. Brain Res Bull. 2002 Apr; 57(6):759-64. PMID: 12031272.
      View in: PubMed
    52. Gritti A, Bonfanti L, Doetsch F, Caille I, Alvarez-Buylla A, Lim D, Galli R, Verdugo JM, Herrera DG, Vescovi AL. Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents. J Neurosci. 2002 Jan 15; 22(2):437-45. PMID: 11784788.
      View in: PubMed
    53. Lim D, Tramontin AD, Trevejo JM, Herrera DG, García-Verdugo JM, Alvarez-Buylla A. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron. 2000 Dec; 28(3):713-26. PMID: 11163261.
      View in: PubMed
    54. Li XC, Jarvis ED, Alvarez-Borda B, Lim D, Nottebohm F. A relationship between behavior, neurotrophin expression, and new neuron survival. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8584-9. PMID: 10890902; PMCID: PMC26991.
      View in: PubMed, PubMed Central
    55. Lim D, Alvarez-Buylla A. Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7526-31. PMID: 10377448; PMCID: PMC22119.
      View in: PubMed, PubMed Central
    56. Doetsch F, Caillé I, Lim D, García-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 1999 Jun 11; 97(6):703-16. PMID: 10380923.
      View in: PubMed
    57. García-Verdugo JM, Doetsch F, Wichterle H, Lim D, Alvarez-Buylla A. Architecture and cell types of the adult subventricular zone: in search of the stem cells. J Neurobiol. 1998 Aug; 36(2):234-48. PMID: 9712307.
      View in: PubMed
    58. Lim D, Gossen M, Lehman CW, Botchan MR. Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control. J Virol. 1998 Mar; 72(3):1931-40. PMID: 9499046; PMCID: PMC109485.
      View in: PubMed, PubMed Central
    59. Lim D, Fishell GJ, Alvarez-Buylla A. Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14832-6. PMID: 9405699; PMCID: PMC25123.
      View in: PubMed, PubMed Central
    60. Thorner LK, Lim D, Botchan MR. DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects. J Virol. 1993 Oct; 67(10):6000-14. PMID: 8396665; PMCID: PMC238021.
      View in: PubMed, PubMed Central
    61. Yang L, Mohr I, Fouts E, Lim D, Nohaile M, Botchan M. The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase. Proc Natl Acad Sci U S A. 1993 Jun 1; 90(11):5086-90. PMID: 8389467; PMCID: PMC46659.
      View in: PubMed, PubMed Central
    Daniel's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (252) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (45) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    Back to TOP