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Global signal peptide profiling reveals principles of selective Sec61 inhibition. Nat Chem Biol. 2024 Mar 22.
Wenzell NA, Tuch BB, McMinn DL, Lyons MJ, Kirk CJ, Taunton J. PMID: 38519575.
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PubMed Mentions: Fields:
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Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors. Protein Sci. 2023 08; 32(8):e4712.
Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi TC, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, Vigneron S, Young NJ, Kondratov IS, Alisoltani A, Simons LM, Lorenzo-Redondo R, Ozer EA, Hultquist JF, O'Donoghue AJ, Moroz YS, Taunton J, Renslo AR, Irwin JJ, García-Sastre A, Shoichet BK, Craik CS. PMID: 37354015; PMCID: PMC10364469.
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PubMed Mentions:
5 Fields:
Translation:
HumansCellsPHPublic Health
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Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat Chem. 2023 Nov; 15(11):1616-1625.
Chen Y, Craven GB, Kamber RA, Cuesta A, Zhersh S, Moroz YS, Bassik MC, Taunton J. PMID: 37460812.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes. Cell. 2023 01 19; 186(2):346-362.e17.
Oltion K, Carelli JD, Yang T, See SK, Wang HY, Kampmann M, Taunton J. PMID: 36638793; PMCID: PMC9994462.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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IFITM proteins assist cellular uptake of diverse linked chemotypes. Science. 2022 12 09; 378(6624):1097-1104.
Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM. PMID: 36480603; PMCID: PMC9924227.
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PubMed Mentions:
4 Fields:
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Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes. Elife. 2022 10 20; 11.
Juette MF, Carelli JD, Rundlet EJ, Brown A, Shao S, Ferguson A, Wasserman MR, Holm M, Taunton J, Blanchard SC. PMID: 36264623; PMCID: PMC9584604.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3. Nat Chem. 2022 12; 14(12):1443-1450.
Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J. PMID: 36123449; PMCID: PMC10018702.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Reversible lysine-targeted probes reveal residence time-based kinase selectivity. Nat Chem Biol. 2022 09; 18(9):934-941.
Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD, Niessen S, Burlingame AL, Carelli JD, Taunton J. PMID: 35590003; PMCID: PMC9970282.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia. Br J Haematol. 2022 07; 198(1):137-141.
Meyer LK, Delgado-Martin C, Sharp PP, Huang BJ, McMinn D, Vincent TL, Ryan T, Horton TM, Wood BL, Teachey DT, Taunton J, Kirk CJ, Hermiston ML. PMID: 35434798; PMCID: PMC9322670.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. ACS Chem Biol. 2021 08 20; 16(8):1354-1364.
Klein VG, Bray WM, Wang HY, Edmondson Q, Schwochert J, Ono S, Naylor MR, Turmon AC, Faris JH, Okada O, Taunton J, Lokey RS. PMID: 34251165; PMCID: PMC8545353.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway. Front Cardiovasc Med. 2020; 7:542485.
Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton J, Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe JI, Le NT. PMID: 33304925; PMCID: PMC7693647.
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PubMed Mentions:
6
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CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Adv. 2020 07 14; 4(13):2899-2911.
Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M. PMID: 32589729; PMCID: PMC7362346.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
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Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking. J Am Chem Soc. 2020 03 18; 142(11):4960-4964.
Wan X, Yang T, Cuesta A, Pang X, Balius TE, Irwin JJ, Shoichet BK, Taunton J. PMID: 32105459; PMCID: PMC7136196.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90. J Am Chem Soc. 2020 02 19; 142(7):3392-3400.
Cuesta A, Wan X, Burlingame AL, Taunton J. PMID: 32009391.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein. JCI Insight. 2019 05 02; 4(9).
Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe JI. PMID: 31045573; PMCID: PMC6538340.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight. 2019 04 04; 4(7).
Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT. PMID: 30944250; PMCID: PMC6483653.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. Circulation. 2019 02 26; 139(9):1199-1216.
Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI. PMID: 30586719; PMCID: PMC6957233.
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Lysine-Targeted Inhibitors and Chemoproteomic Probes. Annu Rev Biochem. 2019 06 20; 88:365-381.
Cuesta A, Taunton J. PMID: 30633551.
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PubMed Mentions:
37 Fields:
Translation:
Cells
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Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018 12 13; 175(7):1931-1945.e18.
Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ. PMID: 30550790; PMCID: PMC6474419.
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PubMed Mentions:
156 Fields:
Translation:
HumansAnimalsCells
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Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica. 2018 07; 103(7):1218-1228.
Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP. PMID: 29622655; PMCID: PMC6029548.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4. Cell Death Dis. 2018 03 14; 9(3):397.
Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE. PMID: 29540678; PMCID: PMC5852046.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells. Sci Signal. 2017 Dec 19; 10(510).
Smith GA, Taunton J, Weiss A. PMID: 29259099; PMCID: PMC5741096.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 12; 31(12):2568-2576.
Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML. PMID: 28484265; PMCID: PMC5729333.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. J Am Chem Soc. 2017 01 18; 139(2):680-685.
Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J. PMID: 28051857; PMCID: PMC5858558.
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PubMed Mentions:
87 Fields:
Translation:
Cells
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Regulation of B cell fate by chronic activity of the IgE B cell receptor. Elife. 2016 12 09; 5.
Yang Z, Robinson MJ, Chen X, Smith GA, Taunton J, Liu W, Allen CD. PMID: 27935477; PMCID: PMC5207771.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell. 2016 11 17; 167(5):1229-1240.e15.
Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS. PMID: 27863242; PMCID: PMC5119991.
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PubMed Mentions:
99 Fields:
Translation:
HumansAnimalsCells
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Mycolactone subverts immunity by selectively blocking the Sec61 translocon. J Exp Med. 2016 12 12; 213(13):2885-2896.
Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C. PMID: 27821549; PMCID: PMC5154940.
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PubMed Mentions:
65 Fields:
Translation:
HumansCells
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Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription. Mol Cell. 2016 10 20; 64(2):347-361.
Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD. PMID: 27768872; PMCID: PMC5081221.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization. Mol Cell. 2016 08 04; 63(3):433-44.
Rodríguez-Molina JB, Tseng SC, Simonett SP, Taunton J, Ansari AZ. PMID: 27477907; PMCID: PMC5122673.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chem Biol. 2016 05 19; 23(5):561-566.
Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. PMID: 27203376.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9.
Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. PMID: 27056844; PMCID: PMC4892427.
View in:
PubMed Mentions:
459 Fields:
Translation:
HumansCells
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Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May; 12(5):373-9.
Smith GA, Uchida K, Weiss A, Taunton J. PMID: 27018889; PMCID: PMC4837022.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. 2016 Jan 19; 44(1):46-58.
Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. PMID: 26789921; PMCID: PMC4878455.
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PubMed Mentions:
80 Fields:
Translation:
HumansCells
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Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. Elife. 2015 Dec 10; 4.
Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J. PMID: 26651998; PMCID: PMC4786417.
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PubMed Mentions:
21 Fields:
Translation:
HumansCells
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Allosteric N-WASP activation by an inter-SH3 domain linker in Nck. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6436-45.
Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J. PMID: 26554011; PMCID: PMC4664294.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Prolonged and tunable residence time using reversible covalent kinase inhibitors. Nat Chem Biol. 2015 Jul; 11(7):525-31.
Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, Gerritsen ME, Funk JO, Owens TD, Verner E, Brameld KA, Hill RJ, Goldstein DM, Taunton J. PMID: 26006010; PMCID: PMC4472506.
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PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 02; 125(3):1299-310.
Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. PMID: 25689261; PMCID: PMC4362265.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum. Oncogene. 2015 Oct 08; 34(41):5288-94.
Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. PMID: 25619841; PMCID: PMC4515412.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Covalent docking of large libraries for the discovery of chemical probes. Nat Chem Biol. 2014 Dec; 10(12):1066-72.
London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermancic P, Bonnet R, Shoichet BK, Taunton J. PMID: 25344815; PMCID: PMC4232467.
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PubMed Mentions:
94 Fields:
Translation:
HumansAnimalsCells
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Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis. J Am Chem Soc. 2014 Sep 10; 136(36):12624-30.
Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. PMID: 25153195; PMCID: PMC4160273.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
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An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. Elife. 2014; 3:e01483.
Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. PMID: 24497544; PMCID: PMC3913039.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Targeting protein kinases with selective and semipromiscuous covalent inhibitors. Methods Enzymol. 2014; 548:93-116.
Miller RM, Taunton J. PMID: 25399643; PMCID: PMC4265651.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J Biol Chem. 2013 Nov 08; 288(45):32528-32538.
Li D, Jin L, Alesi GN, Kim YM, Fan J, Seo JH, Wang D, Tucker M, Gu TL, Lee BH, Taunton J, Magliocca KR, Chen ZG, Shin DM, Khuri FR, Kang S. PMID: 24085294; PMCID: PMC3820886.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 09; 2:e00712.
Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. PMID: 23853713; PMCID: PMC3707081.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Mol Cell Biol. 2013 Jul; 33(13):2574-85.
Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, Khuri FR, Kang S. PMID: 23608533; PMCID: PMC3700113.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Electrophilic fragment-based design of reversible covalent kinase inhibitors. J Am Chem Soc. 2013 Apr 10; 135(14):5298-301.
Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J. PMID: 23540679; PMCID: PMC3665406.
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PubMed Mentions:
62 Fields:
Translation:
HumansCells
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Proteostasis modulators with discriminating taste. Chem Biol. 2013 Feb 21; 20(2):144-5.
Paavilainen VO, Taunton J. PMID: 23438743; PMCID: PMC3647031.
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PubMed Mentions: Fields:
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Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25.
Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. PMID: 23400640; PMCID: PMC3566858.
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PubMed Mentions:
13
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A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99.
Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. PMID: 23243209; PMCID: PMC3574639.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimalsCells
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Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors. J Am Chem Soc. 2012 Dec 19; 134(50):20214-7.
Gushwa NN, Kang S, Chen J, Taunton J. PMID: 23190395; PMCID: PMC3729023.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation. Mol Biol Cell. 2012 Jul; 23(14):2712-22.
Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K. PMID: 22648169; PMCID: PMC3395660.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles. Nat Chem Biol. 2012 Apr 01; 8(5):471-6.
Serafimova IM, Pufall MA, Krishnan S, Duda K, Cohen MS, Maglathlin RL, McFarland JM, Miller RM, Frödin M, Taunton J. PMID: 22466421; PMCID: PMC3657615.
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PubMed Mentions:
149 Fields:
Translation:
Cells
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Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5277-82.
Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. PMID: 22403064; PMCID: PMC3325720.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012 Feb 17; 110(4):536-50.
Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J. PMID: 22267842; PMCID: PMC3306797.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators. Chem Biol. 2011 Sep 23; 18(9):1082-8.
Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J. PMID: 21944747; PMCID: PMC3855466.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nat Methods. 2011 Jul 17; 8(9):753-5.
Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, Collingwood TN, Frodin M, Davis GD. PMID: 21765410; PMCID: PMC3617923.
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236 Fields:
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HumansCells
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Irreversible Nek2 kinase inhibitors with cellular activity. J Med Chem. 2011 Jun 23; 54(12):4133-46.
Henise JC, Taunton J. PMID: 21627121; PMCID: PMC3663048.
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PubMed Mentions:
27 Fields:
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HumansCells
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p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia. Blood. 2011 Jun 23; 117(25):6885-94.
Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, Lin JX, Leonard WJ, Taunton J, Khoury HJ, Kang S. PMID: 21527514; PMCID: PMC3128480.
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PubMed Mentions:
15 Fields:
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HumansAnimalsCells
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Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73.
Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. PMID: 21111236; PMCID: PMC3058345.
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PubMed Mentions:
186 Fields:
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HumansCells
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ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010 Dec 31; 285(53):41310-9.
Oh YT, Liu X, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY. PMID: 21044953; PMCID: PMC3009856.
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PubMed Mentions:
33 Fields:
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HumansCells
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Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia. J Biol Chem. 2010 Nov 05; 285(45):35155-68.
Kintner DB, Chen X, Currie J, Chanana V, Ferrazzano P, Baba A, Matsuda T, Cohen M, Orlowski J, Chiu SY, Taunton J, Sun D. PMID: 20817726; PMCID: PMC2966129.
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PubMed Mentions:
9 Fields:
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AnimalsCells
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p90 activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1. J Neurochem. 2010 Sep 01; 114(5):1476-86.
Manhas N, Shi Y, Taunton J, Sun D. PMID: 20557427; PMCID: PMC2924815.
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PubMed Mentions:
13 Fields:
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AnimalsCells
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RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity. Mol Cell Biol. 2010 Jun; 30(11):2621-35.
Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF. PMID: 20351173; PMCID: PMC2876527.
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PubMed Mentions:
40 Fields:
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HumansAnimalsCells
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p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J Clin Invest. 2010 Apr; 120(4):1165-77.
Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J. PMID: 20234090; PMCID: PMC2846050.
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PubMed Mentions:
75 Fields:
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HumansAnimalsCells
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Target Identification by Diazirine Photo-Cross-linking and Click Chemistry. Curr Protoc Chem Biol. 2009 Dec; 1:55-73.
Mackinnon AL, Taunton J. PMID: 23667793; PMCID: PMC3647699.
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43 Fields:
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RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell. 2009 Aug 28; 35(4):511-22.
Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M. PMID: 19716794; PMCID: PMC3784321.
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PubMed Mentions:
109 Fields:
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HumansAnimalsCells
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The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. J Biol Chem. 2009 Aug 28; 284(35):23670-81.
Chaturvedi D, Cohen MS, Taunton J, Patel TB. PMID: 19570980; PMCID: PMC2749142.
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PubMed Mentions:
18 Fields:
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AnimalsCells
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Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Mol Cell Biol. 2009 Apr; 29(8):2105-17.
Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J. PMID: 19223461; PMCID: PMC2663316.
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PubMed Mentions:
26 Fields:
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AnimalsCells
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Rapamycin induces transactivation of the EGFR and increases cell survival. Oncogene. 2009 Mar 05; 28(9):1187-96.
Chaturvedi D, Gao X, Cohen MS, Taunton J, Patel TB. PMID: 19151764; PMCID: PMC2653860.
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PubMed Mentions:
15 Fields:
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HumansCells
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betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell. 2009 Jan 16; 33(1):109-16.
Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M. PMID: 19150432; PMCID: PMC2655121.
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PubMed Mentions:
109 Fields:
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HumansAnimalsCells
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Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. J Am Chem Soc. 2008 Aug 20; 130(33):11219-22.
Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM. PMID: 18642817; PMCID: PMC3090445.
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PubMed Mentions:
64 Fields:
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HumansCells
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Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity. Circ Res. 2008 Aug 01; 103(3):269-78.
Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H. PMID: 18599872; PMCID: PMC2631445.
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PubMed Mentions:
26 Fields:
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AnimalsCells
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APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes Dev. 2008 Jan 01; 22(1):79-90.
Visintin C, Tomson BN, Rahal R, Paulson J, Cohen M, Taunton J, Amon A, Visintin R. PMID: 18172166; PMCID: PMC2151016.
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PubMed Mentions:
53 Fields:
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AnimalsCells
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Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc. 2007 Nov 28; 129(47):14560-1.
MacKinnon AL, Garrison JL, Hegde RS, Taunton J. PMID: 17983236; PMCID: PMC2574519.
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PubMed Mentions:
54 Fields:
Translation:
Cells
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A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72.
Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. PMID: 18022565; PMCID: PMC2215327.
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PubMed Mentions:
59 Fields:
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FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep; 12(3):201-14.
Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. PMID: 17785202; PMCID: PMC2424114.
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PubMed Mentions:
77 Fields:
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HumansCells
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The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell. 2007 Sep; 18(9):3681-91.
Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. PMID: 17567950; PMCID: PMC1951758.
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PubMed Mentions:
112 Fields:
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HumansAnimalsCells
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RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem. 2007 May 11; 282(19):14056-64.
Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. PMID: 17360704; PMCID: PMC3618456.
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PubMed Mentions:
384 Fields:
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HumansCells
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Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains. Cell. 2007 Mar 09; 128(5):901-13.
Co C, Wong DT, Gierke S, Chang V, Taunton J. PMID: 17350575; PMCID: PMC2047291.
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PubMed Mentions:
98 Fields:
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AnimalsCells
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A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat Chem Biol. 2007 Mar; 3(3):156-60.
Cohen MS, Hadjivassiliou H, Taunton J. PMID: 17259979; PMCID: PMC3634365.
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PubMed Mentions:
56 Fields:
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HumansAnimalsCells
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Recruitment and activation of RSK2 by HIV-1 Tat. PLoS One. 2007 Jan 17; 2(1):e151.
Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. PMID: 17225856; PMCID: PMC1764712.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation. Mol Pharmacol. 2007 Mar; 71(3):799-806.
Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M. PMID: 17142297.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 2006 Aug 25; 126(4):727-39.
Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. PMID: 16923392.
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PubMed Mentions:
119 Fields:
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HumansAnimalsCells
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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 2006 Jun 21; 25(12):2781-91.
Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. PMID: 16763566; PMCID: PMC1500846.
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PubMed Mentions:
230 Fields:
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HumansAnimalsCells
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A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature. 2005 Jul 14; 436(7048):285-9.
Garrison JL, Kunkel EJ, Hegde RS, Taunton J. PMID: 16015336.
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PubMed Mentions:
80 Fields:
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HumansAnimalsCells
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Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science. 2005 May 27; 308(5726):1318-21.
Cohen MS, Zhang C, Shokat KM, Taunton J. PMID: 15919995; PMCID: PMC3641834.
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PubMed Mentions:
184 Fields:
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AnimalsCells
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A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell. 2005 Jan 21; 17(2):181-91.
Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA. PMID: 15664188.
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PubMed Mentions:
91 Fields:
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AnimalsCells
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Organolithium-mediated diversification of peptide thiazoles. Org Lett. 2005 Jan 20; 7(2):299-301.
Deng S, Taunton J. PMID: 15646982.
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PubMed Mentions:
1 Fields:
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Cells
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Kinetic control of proline amide rotamers: total synthesis of trans,trans- and cis,cis-ceratospongamide. J Am Chem Soc. 2002 Feb 13; 124(6):916-7.
Deng S, Taunton J. PMID: 11829594.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Actin filament nucleation by endosomes, lysosomes and secretory vesicles. Curr Opin Cell Biol. 2001 Feb; 13(1):85-91.
Taunton J. PMID: 11163138.
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PubMed Mentions:
29 Fields:
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HumansAnimalsCells
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How to starve a tumor. Chem Biol. 1997 Jul; 4(7):493-6.
Taunton J. PMID: 9263636.
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6 Fields:
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A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996; (272):408-411.
Taunton, J., Hassig, C.A. and Schreiber, S.L.
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Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function. J. Am. Chem. Soc. 1996; (118):10412-10422.
Taunton, J., Collins, J.L. and Schreiber, S.L.
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Total syntheses of di- and tri-O-methyl dynemicin A methyl esters. J. Am. Chem. Soc. 1993; (115):10378-10379.
Taunton, J., Wood, J.L. and Schreiber, S.L.
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Application of the Allylic Diazene Rearrangement: Synthesis of the enediyne-bridged tricyclic core of dynemicin A. J. Am. Chem. Soc. 1992; (114):5898-5900.
Wood, J.L., Porco, J.A., Taunton, J., Lee, A.Y., Clardy, J. and Schreiber, S.L.
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Synthesis of nitrogen-containing polycycles via rhodium(II)-induced cyclization-cycloaddition and insertion reactions of N-(diazoacetoacetyl)amides. Conformational control of reaction selectivity. J. Org. Chem. 1991; (56):820-829.
Doyle, M.P., Pieters, R.J., Taunton, J., Pho, H.Q., Padwa, A., Hertzog, D.L. and Precedo, L.
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Conformational and electronic preferences in rhodium(II) carboxylate and rhodium(II) carboxamide catalyzed carbon-hydrogen insertion reactions of N,N-disubstituted diazoacetoacetamides. Tetrahedron Lett. 1989; (30):5397-5400.
Doyle, M.P., Taunton, J. and Pho, H.Q.
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A new and general synthesis of a-silyl carbonyl compounds by silicon-hydrogen insertion from transition metal-catalyzed reactions of diazo esters and diazo ketones. J. Org. Chem. 1988; (53):6158-6160.
Bagheri, V., Doyle, M.P., Taunton, J. and Claxton, E.E.
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Reactivity and selectivity in intermolecular insertion reactions of chlorophenylcarbene. Tetrahedron Lett. 1988; (29):5863-5866.
Doyle, M.P., Taunton, J., Oon, S.M., Liu, M.T., Soundararajan, N., Platz, M.S. and Jackson, J.E.