Jack Taunton, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th Street
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Trinity UniversityB.S.06/1989Chemistry
    Harvard UniversityPh.D.06/1996Chemistry
    Harvard Medical SchoolPostdoc12/2000Cell Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Substrate-Selective Inhibitors of Secretory and Membrane Protein Biogenesis
    NIH R01GM081644Sep 10, 2007 - Jul 31, 2012
    Role: Principal Investigator
    Highly Selective, Irreversible Protein Kinase Inhibitors
    NIH R01GM071434Apr 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    Membrane Movement Powered by Actin Assembly
    NIH R01GM066229Jul 1, 2002 - Jun 30, 2008
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reversible lysine-targeted probes reveal residence time-based kinase selectivity. Nat Chem Biol. 2022 09; 18(9):934-941. Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD, Niessen S, Burlingame AL, Carelli JD, Taunton J. PMID: 35590003.
      View in: PubMed   Mentions:    Fields:    
    2. Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia. Br J Haematol. 2022 07; 198(1):137-141. Meyer LK, Delgado-Martin C, Sharp PP, Huang BJ, McMinn D, Vincent TL, Ryan T, Horton TM, Wood BL, Teachey DT, Taunton J, Kirk CJ, Hermiston ML. PMID: 35434798; PMCID: PMC9322670.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90. J Am Chem Soc. 2020 02 19; 142(7):3392-3400. Cuesta A, Wan X, Burlingame AL, Taunton J. PMID: 32009391.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    4. Lysine-Targeted Inhibitors and Chemoproteomic Probes. Annu Rev Biochem. 2019 06 20; 88:365-381. Cuesta A, Taunton J. PMID: 30633551.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    5. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018 12 13; 175(7):1931-1945.e18. Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ. PMID: 30550790; PMCID: PMC6474419.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    6. Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica. 2018 07; 103(7):1218-1228. Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP. PMID: 29622655; PMCID: PMC6029548.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells. Sci Signal. 2017 Dec 19; 10(510). Smith GA, Taunton J, Weiss A. PMID: 29259099; PMCID: PMC5741096.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 12; 31(12):2568-2576. Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML. PMID: 28484265; PMCID: PMC5729333.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    9. Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes. J Am Chem Soc. 2017 01 18; 139(2):680-685. Zhao Q, Ouyang X, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J. PMID: 28051857; PMCID: PMC5858558.
      View in: PubMed   Mentions: 59     Fields:    Translation:Cells
    10. Regulation of B cell fate by chronic activity of the IgE B cell receptor. Elife. 2016 12 09; 5. Yang Z, Robinson MJ, Chen X, Smith GA, Taunton J, Liu W, Allen CD. PMID: 27935477; PMCID: PMC5207771.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    11. Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell. 2016 11 17; 167(5):1229-1240.e15. Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS. PMID: 27863242; PMCID: PMC5119991.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    12. Mycolactone subverts immunity by selectively blocking the Sec61 translocon. J Exp Med. 2016 12 12; 213(13):2885-2896. Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C. PMID: 27821549; PMCID: PMC5154940.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    13. Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription. Mol Cell. 2016 10 20; 64(2):347-361. Josefowicz SZ, Shimada M, Armache A, Li CH, Miller RM, Lin S, Yang A, Dill BD, Molina H, Park HS, Garcia BA, Taunton J, Roeder RG, Allis CD. PMID: 27768872; PMCID: PMC5081221.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    14. Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization. Mol Cell. 2016 08 04; 63(3):433-44. Rodríguez-Molina JB, Tseng SC, Simonett SP, Taunton J, Ansari AZ. PMID: 27477907; PMCID: PMC5122673.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    15. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chem Biol. 2016 05 19; 23(5):561-566. Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. PMID: 27203376.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    16. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. PMID: 27056844; PMCID: PMC4892427.
      View in: PubMed   Mentions: 321     Fields:    Translation:HumansCells
    17. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May; 12(5):373-9. Smith GA, Uchida K, Weiss A, Taunton J. PMID: 27018889; PMCID: PMC4837022.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    18. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. 2016 Jan 19; 44(1):46-58. Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. PMID: 26789921; PMCID: PMC4878455.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    19. Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. Elife. 2015 Dec 10; 4. Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J. PMID: 26651998; PMCID: PMC4786417.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    20. Allosteric N-WASP activation by an inter-SH3 domain linker in Nck. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6436-45. Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J. PMID: 26554011; PMCID: PMC4664294.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Prolonged and tunable residence time using reversible covalent kinase inhibitors. Nat Chem Biol. 2015 Jul; 11(7):525-31. Bradshaw JM, McFarland JM, Paavilainen VO, Bisconte A, Tam D, Phan VT, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead DG, Nunn PA, Karr DE, Gerritsen ME, Funk JO, Owens TD, Verner E, Brameld KA, Hill RJ, Goldstein DM, Taunton J. PMID: 26006010; PMCID: PMC4472506.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    22. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 02; 125(3):1299-310. Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. PMID: 25689261; PMCID: PMC4362265.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    23. Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum. Oncogene. 2015 Oct 08; 34(41):5288-94. Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. PMID: 25619841; PMCID: PMC4515412.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    24. Covalent docking of large libraries for the discovery of chemical probes. Nat Chem Biol. 2014 Dec; 10(12):1066-72. London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermancic P, Bonnet R, Shoichet BK, Taunton J. PMID: 25344815; PMCID: PMC4232467.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    25. Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis. J Am Chem Soc. 2014 Sep 10; 136(36):12624-30. Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. PMID: 25153195; PMCID: PMC4160273.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    26. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. Elife. 2014; 3:e01483. Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. PMID: 24497544; PMCID: PMC3913039.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    27. Targeting protein kinases with selective and semipromiscuous covalent inhibitors. Methods Enzymol. 2014; 548:93-116. Miller RM, Taunton J. PMID: 25399643; PMCID: PMC4265651.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    28. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J Biol Chem. 2013 Nov 08; 288(45):32528-32538. Li D, Jin L, Alesi GN, Kim YM, Fan J, Seo JH, Wang D, Tucker M, Gu TL, Lee BH, Taunton J, Magliocca KR, Chen ZG, Shin DM, Khuri FR, Kang S. PMID: 24085294; PMCID: PMC3820886.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    29. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 09; 2:e00712. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. PMID: 23853713; PMCID: PMC3707081.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    30. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Mol Cell Biol. 2013 Jul; 33(13):2574-85. Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, Khuri FR, Kang S. PMID: 23608533; PMCID: PMC3700113.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    31. Electrophilic fragment-based design of reversible covalent kinase inhibitors. J Am Chem Soc. 2013 Apr 10; 135(14):5298-301. Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J. PMID: 23540679; PMCID: PMC3665406.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    32. Proteostasis modulators with discriminating taste. Chem Biol. 2013 Feb 21; 20(2):144-5. Paavilainen VO, Taunton J. PMID: 23438743; PMCID: PMC3647031.
      View in: PubMed   Mentions:    Fields:    
    33. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. PMID: 23400640; PMCID: PMC3566858.
      View in: PubMed   Mentions: 14  
    34. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99. Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. PMID: 23243209; PMCID: PMC3574639.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    35. Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors. J Am Chem Soc. 2012 Dec 19; 134(50):20214-7. Gushwa NN, Kang S, Chen J, Taunton J. PMID: 23190395; PMCID: PMC3729023.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    36. Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation. Mol Biol Cell. 2012 Jul; 23(14):2712-22. Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K. PMID: 22648169; PMCID: PMC3395660.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    37. Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles. Nat Chem Biol. 2012 Apr 01; 8(5):471-6. Serafimova IM, Pufall MA, Krishnan S, Duda K, Cohen MS, Maglathlin RL, McFarland JM, Miller RM, Frödin M, Taunton J. PMID: 22466421; PMCID: PMC3657615.
      View in: PubMed   Mentions: 117     Fields:    Translation:Cells
    38. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5277-82. Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. PMID: 22403064; PMCID: PMC3325720.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    39. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012 Feb 17; 110(4):536-50. Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J. PMID: 22267842; PMCID: PMC3306797.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    40. Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators. Chem Biol. 2011 Sep 23; 18(9):1082-8. Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J. PMID: 21944747; PMCID: PMC3855466.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    41. High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nat Methods. 2011 Jul 17; 8(9):753-5. Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, Collingwood TN, Frodin M, Davis GD. PMID: 21765410; PMCID: PMC3617923.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansCells
    42. Irreversible Nek2 kinase inhibitors with cellular activity. J Med Chem. 2011 Jun 23; 54(12):4133-46. Henise JC, Taunton J. PMID: 21627121; PMCID: PMC3663048.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    43. p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia. Blood. 2011 Jun 23; 117(25):6885-94. Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, Lin JX, Leonard WJ, Taunton J, Khoury HJ, Kang S. PMID: 21527514; PMCID: PMC3128480.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    44. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. PMID: 21111236; PMCID: PMC3058345.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansCells
    45. ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010 Dec 31; 285(53):41310-9. Oh YT, Liu X, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY. PMID: 21044953; PMCID: PMC3009856.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    46. Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia. J Biol Chem. 2010 Nov 05; 285(45):35155-68. Kintner DB, Chen X, Currie J, Chanana V, Ferrazzano P, Baba A, Matsuda T, Cohen M, Orlowski J, Chiu SY, Taunton J, Sun D. PMID: 20817726; PMCID: PMC2966129.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    47. p90 activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1. J Neurochem. 2010 Sep 01; 114(5):1476-86. Manhas N, Shi Y, Taunton J, Sun D. PMID: 20557427; PMCID: PMC2924815.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    48. RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity. Mol Cell Biol. 2010 Jun; 30(11):2621-35. Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF. PMID: 20351173; PMCID: PMC2876527.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    49. p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J Clin Invest. 2010 Apr; 120(4):1165-77. Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J. PMID: 20234090; PMCID: PMC2846050.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    50. Target Identification by Diazirine Photo-Cross-linking and Click Chemistry. Curr Protoc Chem Biol. 2009 Dec; 1:55-73. Mackinnon AL, Taunton J. PMID: 23667793; PMCID: PMC3647699.
      View in: PubMed   Mentions: 33     Fields:    
    51. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell. 2009 Aug 28; 35(4):511-22. Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M. PMID: 19716794; PMCID: PMC3784321.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    52. The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. J Biol Chem. 2009 Aug 28; 284(35):23670-81. Chaturvedi D, Cohen MS, Taunton J, Patel TB. PMID: 19570980; PMCID: PMC2749142.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    53. Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Mol Cell Biol. 2009 Apr; 29(8):2105-17. Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J. PMID: 19223461; PMCID: PMC2663316.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    54. Rapamycin induces transactivation of the EGFR and increases cell survival. Oncogene. 2009 Mar 05; 28(9):1187-96. Chaturvedi D, Gao X, Cohen MS, Taunton J, Patel TB. PMID: 19151764; PMCID: PMC2653860.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    55. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell. 2009 Jan 16; 33(1):109-16. Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M. PMID: 19150432; PMCID: PMC2655121.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    56. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. J Am Chem Soc. 2008 Aug 20; 130(33):11219-22. Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM. PMID: 18642817; PMCID: PMC3090445.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    57. Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity. Circ Res. 2008 Aug 01; 103(3):269-78. Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H. PMID: 18599872; PMCID: PMC2631445.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    58. APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes Dev. 2008 Jan 01; 22(1):79-90. Visintin C, Tomson BN, Rahal R, Paulson J, Cohen M, Taunton J, Amon A, Visintin R. PMID: 18172166; PMCID: PMC2151016.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    59. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc. 2007 Nov 28; 129(47):14560-1. MacKinnon AL, Garrison JL, Hegde RS, Taunton J. PMID: 17983236; PMCID: PMC2574519.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    60. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. PMID: 18022565; PMCID: PMC2215327.
      View in: PubMed   Mentions: 56     Fields:    
    61. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep; 12(3):201-14. Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. PMID: 17785202; PMCID: PMC2424114.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    62. The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell. 2007 Sep; 18(9):3681-91. Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. PMID: 17567950; PMCID: PMC1951758.
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    63. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem. 2007 May 11; 282(19):14056-64. Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. PMID: 17360704; PMCID: PMC3618456.
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    64. Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains. Cell. 2007 Mar 09; 128(5):901-13. Co C, Wong DT, Gierke S, Chang V, Taunton J. PMID: 17350575; PMCID: PMC2047291.
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    65. A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat Chem Biol. 2007 Mar; 3(3):156-60. Cohen MS, Hadjivassiliou H, Taunton J. PMID: 17259979; PMCID: PMC3634365.
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    66. Recruitment and activation of RSK2 by HIV-1 Tat. PLoS One. 2007 Jan 17; 2(1):e151. Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. PMID: 17225856; PMCID: PMC1764712.
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    67. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation. Mol Pharmacol. 2007 Mar; 71(3):799-806. Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M. PMID: 17142297.
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    68. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 2006 Aug 25; 126(4):727-39. Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. PMID: 16923392.
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    69. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 2006 Jun 21; 25(12):2781-91. Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. PMID: 16763566; PMCID: PMC1500846.
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    70. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature. 2005 Jul 14; 436(7048):285-9. Garrison JL, Kunkel EJ, Hegde RS, Taunton J. PMID: 16015336.
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    71. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science. 2005 May 27; 308(5726):1318-21. Cohen MS, Zhang C, Shokat KM, Taunton J. PMID: 15919995; PMCID: PMC3641834.
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    72. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell. 2005 Jan 21; 17(2):181-91. Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA. PMID: 15664188.
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    73. Organolithium-mediated diversification of peptide thiazoles. Org Lett. 2005 Jan 20; 7(2):299-301. Deng S, Taunton J. PMID: 15646982.
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    74. Kinetic control of proline amide rotamers: total synthesis of trans,trans- and cis,cis-ceratospongamide. J Am Chem Soc. 2002 Feb 13; 124(6):916-7. Deng S, Taunton J. PMID: 11829594.
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    75. Actin filament nucleation by endosomes, lysosomes and secretory vesicles. Curr Opin Cell Biol. 2001 Feb; 13(1):85-91. Taunton J. PMID: 11163138.
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    76. How to starve a tumor. Chem Biol. 1997 Jul; 4(7):493-6. Taunton J. PMID: 9263636.
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    77. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996; (272):408-411. Taunton, J., Hassig, C.A. and Schreiber, S.L.
    78. Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function. J. Am. Chem. Soc. 1996; (118):10412-10422. Taunton, J., Collins, J.L. and Schreiber, S.L.
    79. Total syntheses of di- and tri-O-methyl dynemicin A methyl esters. J. Am. Chem. Soc. 1993; (115):10378-10379. Taunton, J., Wood, J.L. and Schreiber, S.L.
    80. Application of the Allylic Diazene Rearrangement: Synthesis of the enediyne-bridged tricyclic core of dynemicin A. J. Am. Chem. Soc. 1992; (114):5898-5900. Wood, J.L., Porco, J.A., Taunton, J., Lee, A.Y., Clardy, J. and Schreiber, S.L.
    81. Synthesis of nitrogen-containing polycycles via rhodium(II)-induced cyclization-cycloaddition and insertion reactions of N-(diazoacetoacetyl)amides. Conformational control of reaction selectivity. J. Org. Chem. 1991; (56):820-829. Doyle, M.P., Pieters, R.J., Taunton, J., Pho, H.Q., Padwa, A., Hertzog, D.L. and Precedo, L.
    82. Conformational and electronic preferences in rhodium(II) carboxylate and rhodium(II) carboxamide catalyzed carbon-hydrogen insertion reactions of N,N-disubstituted diazoacetoacetamides. Tetrahedron Lett. 1989; (30):5397-5400. Doyle, M.P., Taunton, J. and Pho, H.Q.
    83. Reactivity and selectivity in intermolecular insertion reactions of chlorophenylcarbene. Tetrahedron Lett. 1988; (29):5863-5866. Doyle, M.P., Taunton, J., Oon, S.M., Liu, M.T., Soundararajan, N., Platz, M.S. and Jackson, J.E.
    84. A new and general synthesis of a-silyl carbonyl compounds by silicon-hydrogen insertion from transition metal-catalyzed reactions of diazo esters and diazo ketones. J. Org. Chem. 1988; (53):6158-6160. Bagheri, V., Doyle, M.P., Taunton, J. and Claxton, E.E.
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