Loading...

Jialing Liu, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Phone415-575-0407
vCardDownload vCard
    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    Boston University Medical CenterPhD/ImmunologySchool of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    ShEEP request for High Performance Electrophysiological System for Recording and Closed-Loop Stimulation
    VA IS1BX005033Sep 1, 2019 - Sep 30, 2020
    Role: Principal Investigator
    BLR&D Research Career Scientist Award Application
    VA IK6BX004600Apr 1, 2019 - Mar 31, 2024
    Role: Principal Investigator
    Stroke in females with metabolic syndrome, a vascular perspective
    NIH/NINDS R01NS102886Feb 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Collateral flow and stroke outcome
    VA I01BX003335Jul 1, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Mechanisms underlying Netrin-1-mediated functional recovery after stroke
    VA I01RX000655Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Neuroplasticity after experimental stroke
    NIH/NINDS R01NS071050Apr 15, 2011 - Feb 29, 2016
    Role: Principal Investigator
    Proteomics study of neurogenesis signaling after stroke
    NIH/NINDS R21NS051576May 23, 2005 - Mar 31, 2009
    Role: Principal Investigator
    Neural stem cell and brain plasticity after stroke
    NIH/NINDS R01NS040469Jun 1, 2001 - May 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. He JW, Rabiller G, Nishijima Y, Akamatsu Y, Khateeb K, Yazdan-Shahmorad A, Liu J. Experimental cortical stroke induces aberrant increase of sharp-wave-associated ripples in the hippocampus and disrupts cortico-hippocampal communication. J Cereb Blood Flow Metab. 2019 Sep 26; 271678X19877889. PMID: 31558106.
      View in: PubMed
    2. Gratianne Rabiller, Atsushi Kanoke, Shunsuke Omadaka, Jialing Liu. Abstract WP160: The Effect of Type II Diabetes on Neural Differentiation and the Transcriptome Landscape of the Neurogenic Zones Following Ischemic Stroke. Stroke. 2019 Feb 1; 50(Suppl_1).
      View in: Publisher Site
    3. Shunsuke Omodaka, Atsushi Kanoke, Christine Hsieh, Walter L Eckalbar, Jialing Liu. Abstract TP130: Transcriptome Analysis of Mononuclear Cell Responses After Ischemic Stroke in Type 2 Diabetic Mice. Stroke. 2019 Feb 1; 50(Suppl_1).
      View in: Publisher Site
    4. Atsushi Kanoke, Shunsuke Omodaka, Yosuke Akamatsu, Yasuo Nishijima, Takayuki Sugawara, Teiji Tominaga, Ruikang K Wang, Jialing Liu. Abstract WP338: Penetrating Arteriole Flow Dynamics and Capillary Transient Time Heterogeneity Following Experimental Stroke in Two Mouse Strains With Distinct Pial Collateral Circulation. Stroke. 2019 Feb 1; 50(Suppl_1).
      View in: Publisher Site
    5. Kurisu K, Zheng Z, Kim JY, Shi J, Kanoke A, Liu J, Hsieh CL, Yenari MA. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. J Cereb Blood Flow Metab. 2019 Oct; 39(10):1906-1918. PMID: 30523715.
      View in: PubMed
    6. Li Y, Choi WJ, Wei W, Song S, Zhang Q, Liu J, Wang RK. Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography. Neurobiol Aging. 2018 10; 70:148-159. PMID: 30007164.
      View in: PubMed
    7. Atsushi Kanoke, Yuandong Li, Shaozhen Song, Ruikang K Wang, Jialing Liu. Abstract WP410: Reduced Recovery of Penetrating Arteriole Flow and Increased Capillary Transit Time Heterogeneity After Stroke in Type 2 Diabetic Mice. Stroke. 2018 Jan 22; 49(Suppl_1).
      View in: Publisher Site
    8. Gratianne Rabiller, Atsushi Kanoke, Mathieu AP Daynac, Claudia Petritsch, Jialing Liu. Abstract TMP29: Type II Diabetes Induces an Early Decline of Neurogenesis With Increased Morphological Alteration in Neuroblasts. Stroke. 2018 Jan 22; 49(Suppl_1).
      View in: Publisher Site
    9. Schmitt O, Badurek S, Liu W, Wang Y, Rabiller G, Kanoke A, Eipert P, Liu J. Prediction of regional functional impairment following experimental stroke via connectome analysis. Sci Rep. 2017 04 13; 7:46316. PMID: 28406178.
      View in: PubMed
    10. Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM. A data-driven approach for evaluating multi-modal therapy in traumatic brain injury. Sci Rep. 2017 02 16; 7:42474. PMID: 28205533.
      View in: PubMed
    11. Nishijima Y, Akamatsu Y, Yang SY, Lee CC, Baran U, Song S, Wang RK, Tominaga T, Liu J. Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice. Stroke. 2016 12; 47(12):3014-3021. PMID: 27834741.
      View in: PubMed
    12. Kobeissy FH, Hansen K, Neumann M, Fu S, Jin K, Liu J. Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach. Front Mol Neurosci. 2016; 9:98. PMID: 27799894.
      View in: PubMed
    13. Neumann M, Liu W, Sun C, Yang SY, Noble-Haeusslein LJ, Liu J. Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum. Behav Brain Res. 2018 03 15; 340:165-171. PMID: 27614007.
      View in: PubMed
    14. Rabiller G, He JW, Nishijima Y, Wong A, Liu J. Perturbation of Brain Oscillations after Ischemic Stroke: A Potential Biomarker for Post-Stroke Function and Therapy. Int J Mol Sci. 2015 Oct 26; 16(10):25605-40. PMID: 26516838.
      View in: PubMed
    15. Liu J. Poststroke angiogenesis: blood, bloom, or brood? Stroke. 2015 May; 46(5):e105-6. PMID: 25813191.
      View in: PubMed
    16. Nishijima Y, Akamatsu Y, Weinstein PR, Liu J. Collaterals: Implications in cerebral ischemic diseases and therapeutic interventions. Brain Res. 2015 Oct 14; 1623:18-29. PMID: 25770816.
      View in: PubMed
    17. Akamatsu Y, Nishijima Y, Lee CC, Yang SY, Shi L, An L, Wang RK, Tominaga T, Liu J. Impaired leptomeningeal collateral flow contributes to the poor outcome following experimental stroke in the Type 2 diabetic mice. J Neurosci. 2015 Mar 04; 35(9):3851-64. PMID: 25740515.
      View in: PubMed
    18. Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection. Ann Clin Transl Neurol. 2014 Nov; 1(11):851-66. PMID: 25540800.
      View in: PubMed
    19. Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC. CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury. J Neurotrauma. 2014 Oct 15; 31(20):1677-88. PMID: 24806994.
      View in: PubMed
    20. Liu J. LOX-1 and neurodegeneration. Neurosci Lett. 2014 Sep 19; 580:179-81. PMID: 24929221.
      View in: PubMed
    21. Liu J, Wang Y, Akamatsu Y, Lee CC, Stetler RA, Lawton MT, Yang GY. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol. 2014 Apr; 115:138-56. PMID: 24291532.
      View in: PubMed
    22. Sun C, Sun H, Wu S, Lee CC, Akamatsu Y, Wang RK, Kernie SG, Liu J. Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway. J Neurosci. 2013 Oct 30; 33(44):17314-25. PMID: 24174664.
      View in: PubMed
    23. Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa S, Swanson RA, Liu J. Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury. Neurorehabil Neural Repair. 2013 Nov-Dec; 27(9):889-99. PMID: 23778701.
      View in: PubMed
    24. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. PMID: 23630120.
      View in: PubMed
    25. Namura S, Ooboshi H, Liu J, Yenari MA. Neuroprotection after cerebral ischemia. Ann N Y Acad Sci. 2013 Mar; 1278:25-32. PMID: 23488559.
      View in: PubMed
    26. Won SJ, Kim JH, Yoo BH, Sohn M, Kauppinen TM, Park MS, Kwon HJ, Liu J, Suh SW. Prevention of hypoglycemia-induced neuronal death by minocycline. J Neuroinflammation. 2012 Sep 22; 9:225. PMID: 22998689.
      View in: PubMed
    27. Won SJ, Yoo BH, Kauppinen TM, Choi BY, Kim JH, Jang BG, Lee MW, Sohn M, Liu J, Swanson RA, Suh SW. Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats. J Neuroinflammation. 2012 Jul 25; 9:182. PMID: 22830525.
      View in: PubMed
    28. d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA. Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation. 2012 Feb 15; 9:31. PMID: 22335939.
      View in: PubMed
    29. Sun H, Le T, Chang TT, Habib A, Wu S, Shen F, Young WL, Su H, Liu J. AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke. Neurobiol Dis. 2011 Oct; 44(1):73-83. PMID: 21726647.
      View in: PubMed
    30. Yonggang Wang, Bruno Bontempi, Xavier Leinekugel, Edith Lesburguères, Wei Liu, Philip R. Weinstein, Jizong Zhao, Gary M. Abrams, Jialing Liu. Environmental Enrichment Preserves Cortical Inputs to the Parahippocampal Areas and Reduces Post Stroke Diaschisis. American Journal of Neuroprotection and Neuroregeneration. 2011 Jun 1; 3(1):66-76.
      View in: Publisher Site
    31. Wang Y, Neumann M, Hansen K, Hong SM, Kim S, Noble-Haeusslein LJ, Liu J. Fluoxetine increases hippocampal neurogenesis and induces epigenetic factors but does not improve functional recovery after traumatic brain injury. J Neurotrauma. 2011 Feb; 28(2):259-68. PMID: 21175261.
      View in: PubMed
    32. Suh SW, Won SJ, Hamby AM, Yoo BH, Fan Y, Sheline CT, Tamano H, Takeda A, Liu J. Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J Cereb Blood Flow Metab. 2009 Sep; 29(9):1579-88. PMID: 19536073.
      View in: PubMed
    33. Neumann M, Wang Y, Kim S, Hong SM, Jeng L, Bilgen M, Liu J. Assessing gait impairment following experimental traumatic brain injury in mice. J Neurosci Methods. 2009 Jan 15; 176(1):34-44. PMID: 18805438.
      View in: PubMed
    34. Wang Y, Bontempi B, Hong SM, Mehta K, Weinstein PR, Abrams GM, Liu J. A comprehensive analysis of gait impairment after experimental stroke and the therapeutic effect of environmental enrichment in rats. J Cereb Blood Flow Metab. 2008 Dec; 28(12):1936-50. PMID: 18628778.
      View in: PubMed
    35. Rapp JH, Pan XM, Neumann M, Hong M, Hollenbeck K, Liu J. Microemboli composed of cholesterol crystals disrupt the blood-brain barrier and reduce cognition. Stroke. 2008 Aug; 39(8):2354-61. PMID: 18566307.
      View in: PubMed
    36. Iwai M, Cao G, Yin W, Stetler RA, Liu J, Chen J. Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia/ischemia in rats. Stroke. 2007 Oct; 38(10):2795-803. PMID: 17702962.
      View in: PubMed
    37. Hong SM, Liu Z, Fan Y, Neumann M, Won SJ, Lac D, Lum X, Weinstein PR, Liu J. Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice. Exp Neurol. 2007 Jul; 206(1):24-32. PMID: 17490651.
      View in: PubMed
    38. Fan Y, Liu Z, Weinstein PR, Fike JR, Liu J. Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. Eur J Neurosci. 2007 Jan; 25(1):38-46. PMID: 17241265.
      View in: PubMed
    39. Liu Z, Fan Y, Won SJ, Neumann M, Hu D, Zhou L, Weinstein PR, Liu J. Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia. Stroke. 2007 Jan; 38(1):146-52. PMID: 17122429.
      View in: PubMed
    40. Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J. Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70. Stroke. 2006 Feb; 37(2):507-12. PMID: 16397188.
      View in: PubMed
    41. Matsumori Y, Hong SM, Fan Y, Kayama T, Hsu CY, Weinstein PR, Liu J. Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia. Neurobiol Dis. 2006 Apr; 22(1):187-98. PMID: 16361108.
      View in: PubMed
    42. Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci. 2006 Jan; 9(1):119-26. PMID: 16311588.
      View in: PubMed
    43. Yasuhiko Matsumori, Shwuhuey M Hong, Yang Fan, Zhengyan Liu, Philip R Weinstein, Chung Y Hsu, Jialing Liu. Enriched environment and learning enhances neurogenesis and peri-infarct neuronal density after cerebral focal ischemia. Journal of Cerebral Blood Flow & Metabolism. 2005 Aug 1; 25(1_suppl):s210-s210.
      View in: Publisher Site
    44. Zhengyan Liu, Yang Fan, Shwuhuey M Hong, Jialing Liu. Minocycline enhances neurogenesis and functional recovery after stroke injury. Journal of Cerebral Blood Flow & Metabolism. 2005 Aug 1; 25(1_suppl):s239-s239.
      View in: Publisher Site
    45. Yenari MA, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG. Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann N Y Acad Sci. 2005 Aug; 1053:74-83. PMID: 16179510.
      View in: PubMed
    46. Matsumori Y, Hong SM, Aoyama K, Fan Y, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J. Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab. 2005 Jul; 25(7):899-910. PMID: 15744251.
      View in: PubMed
    47. Suh SW, Aoyama K, Matsumori Y, Liu J, Swanson RA. Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. Diabetes. 2005 May; 54(5):1452-8. PMID: 15855333.
      View in: PubMed
    48. Suh SW, Fan Y, Hong SM, Liu Z, Matsumori Y, Weinstein PR, Swanson RA, Liu J. Hypoglycemia induces transient neurogenesis and subsequent progenitor cell loss in the rat hippocampus. Diabetes. 2005 Feb; 54(2):500-9. PMID: 15677508.
      View in: PubMed
    49. Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA. Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Nat Biotechnol. 2004 Jun; 22(6):724-31. PMID: 15146195.
      View in: PubMed
    50. Raber J, Fan Y, Matsumori Y, Liu Z, Weinstein PR, Fike JR, Liu J. Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits. Ann Neurol. 2004 Mar; 55(3):381-9. PMID: 14991816.
      View in: PubMed
    51. Gum ET, Swanson RA, Alano C, Liu J, Hong S, Weinstein PR, Panter SS. Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death. Stroke. 2004 Feb; 35(2):590-5. PMID: 14726550.
      View in: PubMed
    52. Suh SW, Aoyama K, Chen Y, Garnier P, Matsumori Y, Gum E, Liu J, Swanson RA. Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. J Neurosci. 2003 Nov 19; 23(33):10681-90. PMID: 14627653.
      View in: PubMed
    53. Tsuchiya D, Hong S, Matsumori Y, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR. Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures. Neurosurgery. 2003 Nov; 53(5):1179-87; discussion 1187-8. PMID: 14580286.
      View in: PubMed
    54. Kokubo Y, Liu J, Rajdev S, Kayama T, Sharp FR, Weinstein PR. Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemia. Neurosurgery. 2003 Jul; 53(1):186-90; discussion 190-1. PMID: 12823888.
      View in: PubMed
    55. Tsuchiya D, Hong S, Matsumori Y, Shiina H, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR. Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia. J Cereb Blood Flow Metab. 2003 Jun; 23(6):718-27. PMID: 12796720.
      View in: PubMed
    56. Kokubo Y, Matson GB, Liu J, Mancuso A, Kayama T, Sharp FR, Weinstein PR. Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats. J Neurosurg. 2002 Jun; 96(6):1084-93. PMID: 12066911.
      View in: PubMed
    57. Liu J, Bartels M, Lu A, Sharp FR. Microglia/macrophages proliferate in striatum and neocortex but not in hippocampus after brief global ischemia that produces ischemic tolerance in gerbil brain. J Cereb Blood Flow Metab. 2001 Apr; 21(4):361-73. PMID: 11323522.
      View in: PubMed
    58. Jialing Liu, Ramon Bernabeu, Aigang Lu, Frank R. Sharp. Neurogenesis and Gliogenesis in the Postischemic Brain. The Neuroscientist. 2000 Oct 1; 6(5):362-370.
      View in: Publisher Site
    59. Liu J, Ying W, Massa S, Duriez PJ, Swanson RA, Poirier GG, Sharp FR. Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains. Brain Res Mol Brain Res. 2000 Aug 14; 80(1):7-16. PMID: 11039724.
      View in: PubMed
    60. Liu J, Solway K, Messing RO, Sharp FR. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci. 1998 Oct 01; 18(19):7768-78. PMID: 9742147.
      View in: PubMed
    61. Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Stein BA, Longuemare MC. Neuronal regulation of glutamate transporter subtype expression in astrocytes. J Neurosci. 1997 Feb 01; 17(3):932-40. PMID: 8994048.
      View in: PubMed
    62. Liu J, Nickolenko J, Sharp FR. Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8537-41. PMID: 8078918.
      View in: PubMed
    63. Venkataraman L, Francis DA, Wang Z, Liu J, Rothstein TL, Sen R. Cyclosporin-A sensitive induction of NF-AT in murine B cells. Immunity. 1994 Jun; 1(3):189-96. PMID: 7889407.
      View in: PubMed
    64. Liu J, Sen R, Rothstein TL. Abnormal kappa B-binding protein in the cytoplasm of a plasmacytoma cell line that lacks nuclear expression of NF-kappa B. Mol Immunol. 1993 Apr; 30(5):479-89. PMID: 8464429.
      View in: PubMed
    65. Chiles TC, Liu JL, Rothstein TL. Cross-linking of surface Ig receptors on murine B lymphocytes stimulates the expression of nuclear tetradecanoyl phorbol acetate-response element-binding proteins. J Immunol. 1991 Mar 15; 146(6):1730-5. PMID: 1900873.
      View in: PubMed
    66. Liu JL, Chiles TC, Sen RJ, Rothstein TL. Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor. J Immunol. 1991 Mar 01; 146(5):1685-91. PMID: 1993849.
      View in: PubMed