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Midori Yenari, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address4150 Clement St
San Francisco CA 94121
Phone415-750-2011
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    Collapse Research 
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    Heat shock proteins in brain ischemia and stroke
    VA I01BX000589Jan 1, 2011 - Sep 30, 2019
    Role: Principal Investigator
    Inflammatory mechanisms in cerebral ischemia
    NIH/NINDS R01NS040516Jul 1, 2000 - May 31, 2015
    Role: Principal Investigator
    MILD HYPOTHERMIA IN FOCAL CEREBRAL ISCHEMIA
    NIH/NINDS K08NS001860Sep 30, 1995 - Jul 31, 2001
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim JY, Kim N, Zheng Z, Lee JE, Yenari M. 70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target? Stroke. 2016 Aug; 47(8):2103-11. PMID: 27387989.
      View in: PubMed
    2. Lee BH, Lim TH, Yoon YW, Yenari M, Jeong Y. Postinjury Neuroplasticity in Central Neural Networks. Neural Plast. 2015; 2015:857085. PMID: 26557389; PMCID: PMC4628645.
    3. Kacimi R, Yenari M. Pharmacologic heat shock protein 70 induction confers cytoprotection against inflammation in gliovascular cells. Glia. 2015 Jul; 63(7):1200-12. PMID: 25802219.
      View in: PubMed
    4. Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari M. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015 Feb 25; 35(8):3384-96. PMID: 25716838; PMCID: PMC4339351.
    5. Kawabori M, Yenari M. Inflammatory responses in brain ischemia. Curr Med Chem. 2015; 22(10):1258-77. PMID: 25666795.
      View in: PubMed
    6. Kim JY, Yenari M, Lee JE. Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation. Neuroscience. 2015 Feb 12; 286:272-80. PMID: 25485480.
      View in: PubMed
    7. Kim JY, Kim N, Yenari M. Mechanisms and potential therapeutic applications of microglial activation after brain injury. CNS Neurosci Ther. 2015 Apr; 21(4):309-19. PMID: 25475659; PMCID: PMC4376565 [Available on 04/01/16].
    8. Kim N, Kim JY, Yenari M. Pharmacological induction of the 70-kDa heat shock protein protects against brain injury. Neuroscience. 2015 Jan 22; 284:912-9. PMID: 25446362; PMCID: PMC4274155 [Available on 01/22/16].
    9. Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari M, Chang W. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection. Ann Clin Transl Neurol. 2014 Nov; 1(11):851-66. PMID: 25540800; PMCID: PMC4265057.
    10. Kawabori M, Yenari M. The role of the microglia in acute CNS injury. Metab Brain Dis. 2015 Apr; 30(2):381-92. PMID: 24682762; PMCID: PMC4180000 [Available on 04/01/16].
    11. Kim JY, Kawabori M, Yenari M. Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets. Curr Med Chem. 2014; 21(18):2076-97. PMID: 24372209; PMCID: PMC4104826.
    12. Kawabori M, Hokari M, Zheng Z, Kim JY, Calosing C, Hsieh CL, Nakamura MC, Yenari M. Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke. Ther Hypothermia Temp Manag. 2013 Dec 1; 3(4):189-198. PMID: 24380032.
      View in: PubMed
    13. Webster CM, Hokari M, McManus A, Tang XN, Ma H, Kacimi R, Yenari M. Microglial P2Y12 deficiency/inhibition protects against brain ischemia. PLoS One. 2013; 8(8):e70927. PMID: 23940669; PMCID: PMC3733797.
    14. Yenari M, Han HS. Influence of therapeutic hypothermia on regeneration after cerebral ischemia. Front Neurol Neurosci. 2013; 32:122-8. PMID: 23859971; PMCID: PMC4022181.
    15. Kim JY, Kim N, Yenari M, Chang W. Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury. J Neurotrauma. 2013 Jul 1; 30(13):1170-6. PMID: 23360235; PMCID: PMC3700438.
    16. Kim JY, Kim N, Zheng Z, Lee JE, Yenari M. The 70 kDa heat shock protein protects against experimental traumatic brain injury. Neurobiol Dis. 2013 Oct; 58:289-95. PMID: 23816752; PMCID: PMC3799906.
    17. Tang XN, Liu L, Koike MA, Yenari M. Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and blood brain barrier disruption after experimental stroke. Ther Hypothermia Temp Manag. 2013 Jun; 3(2):74-83. PMID: 23781399; PMCID: PMC3684213.
    18. Kawabori M, Kacimi R, Karliner JS, Yenari M. Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets. World J Cardiol. 2013 Apr 26; 5(4):75-86. PMID: 23675553; PMCID: PMC3653015.
    19. Kim JY, Yenari M. The immune modulating properties of the heat shock proteins after brain injury. Anat Cell Biol. 2013 Mar; 46(1):1-7. PMID: 23560231; PMCID: PMC3615608.
    20. Namura S, Ooboshi H, Liu J, Yenari M. Neuroprotection after cerebral ischemia. Ann N Y Acad Sci. 2013 Mar; 1278:25-32. PMID: 23488559; PMCID: PMC3645884.
    21. Park YM, Lee WT, Bokara KK, Seo SK, Park SH, Kim JH, Yenari M, Park KA, Lee JE. The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells. PLoS One. 2013; 8(1):e53911. PMID: 23349763; PMCID: PMC3549976.
    22. Yenari M. Temperature affects thrombolytic efficacy using rt-Pa and eptifibatide, an in vitro study: editorial commentary on Meunier et al., 2012. Ther Hypothermia Temp Manag. 2012 Dec; 2(4):166. PMID: 23667779; PMCID: PMC3621513.
    23. Tang XN, Zheng Z, Yenari M. Bone marrow chimeras in the study of experimental stroke. Transl Stroke Res. 2012 Sep; 3(3):341-7. PMID: 24323809.
      View in: PubMed
    24. Tang XN, Cairns B, Kim JY, Yenari M. NADPH oxidase in stroke and cerebrovascular disease. Neurol Res. 2012 May; 34(4):338-45. PMID: 22643077; PMCID: PMC3645888.
    25. Yenari M, Han HS. Neuroprotective mechanisms of hypothermia in brain ischaemia. Nat Rev Neurosci. 2012 Apr; 13(4):267-78. PMID: 22353781.
      View in: PubMed
    26. Cairns B, Kim JY, Tang XN, Yenari M. NOX inhibitors as a therapeutic strategy for stroke and neurodegenerative disease. Curr Drug Targets. 2012 Feb; 13(2):199-206. PMID: 22204319.
      View in: PubMed
    27. Yenari M, Colbourne F, Hemmen TM, Han HS, Krieger D. Therapeutic hypothermia in stroke. Stroke Res Treat. 2011; 2011:157969. PMID: 22315703; PMCID: PMC3270477.
    28. Kim N, Kim JY, Yenari M. Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury. Inflammopharmacology. 2012 Jun; 20(3):177-85. PMID: 22246599.
      View in: PubMed
    29. Won SJ, Tang XN, Suh SW, Yenari M, Swanson RA. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production. Ann Neurol. 2011 Oct; 70(4):583-90. PMID: 22002675; PMCID: PMC4554391.
    30. Tang XN, Zheng Z, Giffard RG, Yenari M. Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke. Ann Neurol. 2011 Oct; 70(4):606-15. PMID: 22028221; PMCID: PMC3205431.
    31. Yenari M, Lee JE. Brain 11: what's new in stroke research? Expert Rev Neurother. 2011 Sep; 11(9):1235-7. PMID: 21864067.
      View in: PubMed
    32. Shah MP, Zimmerman L, Bullard J, Yenari M. Therapeutic hypothermia after cardiac arrest: experience at an academically affiliated community-based veterans affairs medical center. Stroke Res Treat. 2011; 2011:791639. PMID: 21822471; PMCID: PMC3140133.
    33. Yan J, Xu Y, Zhu C, Zhang L, Wu A, Yang Y, Xiong Z, Deng C, Huang XF, Yenari M, Yang YG, Ying W, Wang Q. Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses. PLoS One. 2011; 6(6):e20945. PMID: 21731633; PMCID: PMC3120752.
    34. Kim JY, Kim N, Yenari M, Chang W. Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression. Transl Stroke Res. 2011 Jun 1; 2(2):195-201. PMID: 21731589; PMCID: PMC3124781.
    35. Kacimi R, Giffard RG, Yenari M. Endotoxin-activated microglia injure brain derived endothelial cells via NF-?B, JAK-STAT and JNK stress kinase pathways. J Inflamm (Lond). 2011; 8:7. PMID: 21385378; PMCID: PMC3061894.
    36. Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, Yenari M. Direct protection of cultured neurons from ischemia-like injury by minocycline. Anat Cell Biol. 2010 Dec; 43(4):325-31. PMID: 21267407; PMCID: PMC3026185.
    37. Yenari M, Kauppinen TM, Swanson RA. Microglial activation in stroke: therapeutic targets. Neurotherapeutics. 2010 Oct; 7(4):378-91. PMID: 20880502.
      View in: PubMed
    38. Yenari M, Hemmen TM. Therapeutic hypothermia for brain ischemia: where have we come and where do we go? Stroke. 2010 Oct; 41(10 Suppl):S72-4. PMID: 20876510; PMCID: PMC2953728.
    39. Jung HJ, Yang MZ, Kwon KH, Yenari M, Choi YJ, Lee WT, Park KA, Lee JE. Endogenous agmatine inhibits cerebral vascular matrix metalloproteinases expression by regulating activating transcription factor 3 and endothelial nitric oxide synthesis. Curr Neurovasc Res. 2010 Aug; 7(3):201-12. PMID: 20560878.
      View in: PubMed
    40. Yenari M, Steinberg GK, Marks MP. Migraine and vertebrobasilar dissection: Case reports. J Stroke Cerebrovasc Dis. 1994; 4(1):36-41. PMID: 26487533.
      View in: PubMed
    41. Tang XN, Berman AE, Swanson RA, Yenari M. Digitally quantifying cerebral hemorrhage using Photoshop and Image J. J Neurosci Methods. 2010 Jul 15; 190(2):240-3. PMID: 20452374; PMCID: PMC2898728.
    42. Wang Q, Yan J, Chen X, Li J, Yang Y, Weng J, Deng C, Yenari M. Statins: multiple neuroprotective mechanisms in neurodegenerative diseases. Exp Neurol. 2011 Jul; 230(1):27-34. PMID: 20406638.
      View in: PubMed
    43. Li Y, Huang XF, Deng C, Meyer B, Wu A, Yu Y, Ying W, Yang GY, Yenari M, Wang Q. Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats. Synapse. 2010 Mar; 64(3):224-30. PMID: 19862688.
      View in: PubMed
    44. Tang XN, Yenari M. Hypothermia as a cytoprotective strategy in ischemic tissue injury. Ageing Res Rev. 2010 Jan; 9(1):61-8. PMID: 19833233; PMCID: PMC2818269.
    45. Vexler ZS, Yenari M. Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci. 2009; 31(5):378-93. PMID: 19672067; PMCID: PMC2790734.
    46. Wang Q, van Hoecke M, Tang XN, Lee H, Zheng Z, Swanson RA, Yenari M. Pyruvate protects against experimental stroke via an anti-inflammatory mechanism. Neurobiol Dis. 2009 Oct; 36(1):223-31. PMID: 19635562; PMCID: PMC2742567.
    47. Liu L, Yenari M. Clinical application of therapeutic hypothermia in stroke. Neurol Res. 2009 May; 31(4):331-5. PMID: 19508813; PMCID: PMC2748785.
    48. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56. PMID: 19302484; PMCID: PMC3087597.
    49. Tang XN, Liu L, Yenari M. Combination therapy with hypothermia for treatment of cerebral ischemia. J Neurotrauma. 2009 Mar; 26(3):325-31. PMID: 19216635; PMCID: PMC2752358.
    50. Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari M, Swanson RA. Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann Neurol. 2008 Dec; 64(6):654-63. PMID: 19107988; PMCID: PMC4304737.
    51. Webster CM, Kelly S, Koike MA, Chock VY, Giffard RG, Yenari M. Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia. Neurobiol Dis. 2009 Feb; 33(2):301-12. PMID: 19063968; PMCID: PMC2737398.
    52. Yenari M, Kitagawa K, Lyden P, Perez-Pinzon M. Metabolic downregulation: a key to successful neuroprotection? Stroke. 2008 Oct; 39(10):2910-7. PMID: 18658035; PMCID: PMC2597567.
    53. Bright R, Sun GH, Yenari M, Steinberg GK, Mochly-Rosen D. epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury. Neurosci Lett. 2008 Aug 15; 441(1):120-4. PMID: 18586397; PMCID: PMC2597630.
    54. Tang XN, Cairns B, Cairns N, Yenari M. Apocynin improves outcome in experimental stroke with a narrow dose range. Neuroscience. 2008 Jun 23; 154(2):556-62. PMID: 18511205; PMCID: PMC2518451.
    55. Wang Q, Zengin A, Ying W, Newell KA, Wang P, Yeo W, Wong PT, Yenari M, Huang XF. Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain. Neuroscience. 2008 Jun 26; 154(3):1100-6. PMID: 18501522.
      View in: PubMed
    56. Liu L, Kim JY, Koike MA, Yoon YJ, Tang XN, Ma H, Lee H, Steinberg GK, Lee JE, Yenari M. FasL shedding is reduced by hypothermia in experimental stroke. J Neurochem. 2008 Jul; 106(2):541-50. PMID: 18410517; PMCID: PMC2735469.
    57. Tang XN, Wang Q, Koike MA, Cheng D, Goris ML, Blankenberg FG, Yenari M. Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia. J Nucl Med. 2007 Nov; 48(11):1822-8. PMID: 17942809.
      View in: PubMed
    58. Zhao H, Wang JQ, Shimohata T, Sun G, Yenari M, Sapolsky RM, Steinberg GK. Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion. J Neurosurg. 2007 Sep; 107(3):636-41. PMID: 17886565.
      View in: PubMed
    59. Zheng Z, Kim JY, Ma H, Lee JE, Yenari M. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. J Cereb Blood Flow Metab. 2008 Jan; 28(1):53-63. PMID: 17473852.
      View in: PubMed
    60. Rapp JH, Wakil L, Sawhney R, Pan XM, Yenari M, Glastonbury C, Coogan S, Wintermark M. Subclinical embolization after carotid artery stenting: new lesions on diffusion-weighted magnetic resonance imaging occur postprocedure. J Vasc Surg. 2007 May; 45(5):867-72; discussion 872-4. PMID: 17376643.
      View in: PubMed
    61. Liu L, Yenari M. Therapeutic hypothermia: neuroprotective mechanisms. Front Biosci. 2007; 12:816-25. PMID: 17127332.
      View in: PubMed
    62. Wang Q, Tang XN, Yenari M. The inflammatory response in stroke. J Neuroimmunol. 2007 Mar; 184(1-2):53-68. PMID: 17188755; PMCID: PMC1868538.
    63. Yenari M, Swanson RA. INTRODUCTION: Immune mechanisms of neurodegeneration. Clin Neurosci Res. 2006 Dec; 6(5):225. PMID: 17464366.
      View in: PubMed
    64. Vexler ZS, Tang XN, Yenari M. Inflammation in adult and neonatal stroke. Clin Neurosci Res. 2006 Dec 1; 6(5):293-313. PMID: 20300490.
      View in: PubMed
    65. Wang Q, Tang XN, Wang L, Yenari M, Ying W, Goh BC, Lee HS, Wilder-Smith EP, Wong PT. Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats. Neurosci Lett. 2006 Nov 20; 408(3):189-93. PMID: 16996211.
      View in: PubMed
    66. Yenari M, Han HS. Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB). Neurochem Int. 2006 Jul; 49(2):164-9. PMID: 16750872.
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    67. Yenari M, Xu L, Tang XN, Qiao Y, Giffard RG. Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro. Stroke. 2006 Apr; 37(4):1087-93. PMID: 16497985.
      View in: PubMed
    68. Blankenberg FG, Kalinyak J, Liu L, Koike M, Cheng D, Goris ML, Green A, Vanderheyden JL, Tong DC, Yenari M. 99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibody. Eur J Nucl Med Mol Imaging. 2006 May; 33(5):566-74. PMID: 16477433.
      View in: PubMed
    69. Lyden PD, Krieger D, Yenari M, Dietrich WD. Therapeutic hypothermia for acute stroke. Int J Stroke. 2006 Feb; 1(1):9-19. PMID: 18706063.
      View in: PubMed
    70. Zheng Z, Yenari M. The application of HSP70 as a target for gene therapy. Front Biosci. 2006; 11:699-707. PMID: 16146762.
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    71. Zhao H, Yenari M, Cheng D, Sapolsky RM, Steinberg GK. Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia. J Cereb Blood Flow Metab. 2005 Sep; 25(9):1119-29. PMID: 15789032.
      View in: PubMed
    72. Lee JE, Yoon YJ, Moseley ME, Yenari M. Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke. J Neurosurg. 2005 Aug; 103(2):289-97. PMID: 16175859.
      View in: PubMed
    73. Yenari M, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG. Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann N Y Acad Sci. 2005 Aug; 1053:74-83. PMID: 16179510.
      View in: PubMed
    74. Kelly S, Cheng D, Steinberg GK, Yenari M. Mild hypothermia decreases GSK3beta expression following global cerebral ischemia. Neurocrit Care. 2005; 2(2):212-7. PMID: 16159068.
      View in: PubMed
    75. Yenari M, Sapolsky RM. Gene therapy in neurological disease. Methods Mol Med. 2005; 104:75-88. PMID: 15454665.
      View in: PubMed
    76. Zheng Z, Yenari M. Post-ischemic inflammation: molecular mechanisms and therapeutic implications. Neurol Res. 2004 Dec; 26(8):884-92. PMID: 15727272.
      View in: PubMed
    77. Kim JH, Yenari M, Giffard RG, Cho SW, Park KA, Lee JE. Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Exp Neurol. 2004 Sep; 189(1):122-30. PMID: 15296842.
      View in: PubMed
    78. Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari M, Mochly-Rosen D. Protein kinase C delta mediates cerebral reperfusion injury in vivo. J Neurosci. 2004 Aug 4; 24(31):6880-8. PMID: 15295022.
      View in: PubMed
    79. Giffard RG, Xu L, Zhao H, Carrico W, Ouyang Y, Qiao Y, Sapolsky R, Steinberg G, Hu B, Yenari M. Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury. J Exp Biol. 2004 Aug; 207(Pt 18):3213-20. PMID: 15299042.
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    80. Kelly S, Zhao H, Hua Sun G, Cheng D, Qiao Y, Luo J, Martin K, Steinberg GK, Harrison SD, Yenari M. Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia. Exp Neurol. 2004 Aug; 188(2):378-86. PMID: 15246837.
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    81. Kelly S, Bliss TM, Shah AK, Sun GH, Ma M, Foo WC, Masel J, Yenari M, Weissman IL, Uchida N, Palmer T, Steinberg GK. Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11839-44. PMID: 15280535; PMCID: PMC511061.
    82. Zhao H, Yenari M, Cheng D, Barreto-Chang OL, Sapolsky RM, Steinberg GK. Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat. J Cereb Blood Flow Metab. 2004 Jun; 24(6):681-92. PMID: 15181376.
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    83. Krieger DW, Yenari M. Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us? Stroke. 2004 Jun; 35(6):1482-9. PMID: 15073396.
      View in: PubMed
    84. Lee JE, Kim YJ, Kim JY, Lee WT, Yenari M, Giffard RG. The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytes. Neuroreport. 2004 Mar 1; 15(3):499-502. PMID: 15094511.
      View in: PubMed
    85. Gu W, Zhao H, Yenari M, Sapolsky RM, Steinberg GK. Catalase over-expression protects striatal neurons from transient focal cerebral ischemia. Neuroreport. 2004 Mar 1; 15(3):413-6. PMID: 15094494.
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    86. Mari C, Karabiyikoglu M, Goris ML, Tait JF, Yenari M, Blankenberg FG. Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V. Eur J Nucl Med Mol Imaging. 2004 May; 31(5):733-9. PMID: 14985868.
      View in: PubMed
    87. Zhao H, Yenari M, Sapolsky RM, Steinberg GK. Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release. Stroke. 2004 Feb; 35(2):572-7. PMID: 14726551.
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    88. Yenari M. Pathophysiology of acute ischemic stroke. Cleve Clin J Med. 2004 Jan; 71 Suppl 1:S25-7. PMID: 14964478.
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    89. Giffard RG, Yenari M. Many mechanisms for hsp70 protection from cerebral ischemia. J Neurosurg Anesthesiol. 2004 Jan; 16(1):53-61. PMID: 14676570.
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    90. Zheng Z, Zhao H, Steinberg GK, Yenari M. Cellular and molecular events underlying ischemia-induced neuronal apoptosis. Drug News Perspect. 2003 Oct; 16(8):497-503. PMID: 14668947.
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    91. Hoehn B, Yenari M, Sapolsky RM, Steinberg GK. Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke. Stroke. 2003 Oct; 34(10):2489-94. PMID: 14500933.
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    92. Deng H, Han HS, Cheng D, Sun GH, Yenari M. Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation. Stroke. 2003 Oct; 34(10):2495-501. PMID: 12970518.
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    93. Karabiyikoglu M, Han HS, Yenari M, Steinberg GK. Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling. J Neurosurg. 2003 Jun; 98(6):1271-6. PMID: 12816275.
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    94. Zheng Z, Lee JE, Yenari M. Stroke: molecular mechanisms and potential targets for treatment. Curr Mol Med. 2003 Jun; 3(4):361-72. PMID: 12776991.
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    95. Han HS, Yenari M. Cellular targets of brain inflammation in stroke. Curr Opin Investig Drugs. 2003 May; 4(5):522-9. PMID: 12833644.
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    96. Zhao H, Yenari M, Sapolsky RM, Steinberg GK. Prospects for the treatment of stroke using gene therapy. Expert Rev Neurother. 2003 May; 3(3):357-72. PMID: 19810903.
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    97. Yenari M, Zhao H, Giffard RG, Sobel RA, Sapolsky RM, Steinberg GK. Gene therapy and hypothermia for stroke treatment. Ann N Y Acad Sci. 2003 May; 993:54-68; discussion 79-81. PMID: 12853295.
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    98. Han HS, Karabiyikoglu M, Kelly S, Sobel RA, Yenari M. Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab. 2003 May; 23(5):589-98. PMID: 12771574.
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    99. Zhao H, Yenari M, Cheng D, Sapolsky RM, Steinberg GK. Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity. J Neurochem. 2003 May; 85(4):1026-36. PMID: 12716434.
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    100. Maier CM, Sun GH, Cheng D, Yenari M, Chan PH, Steinberg GK. Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemia. Neurobiol Dis. 2002 Oct; 11(1):28-42. PMID: 12460544.
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    101. Kelly S, Zhang ZJ, Zhao H, Xu L, Giffard RG, Sapolsky RM, Yenari M, Steinberg GK. Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2. Ann Neurol. 2002 Aug; 52(2):160-7. PMID: 12210785.
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    102. Adami A, Thijs V, Tong DC, Beaulieu C, Moseley ME, Yenari M. Use of diffusion weighted MRI to predict the occurrence and severity of hemorrhagic transformation in a rabbit model of embolic stroke. Brain Res. 2002 Jul 19; 944(1-2):32-9. PMID: 12106663.
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    103. Han HS, Qiao Y, Karabiyikoglu M, Giffard RG, Yenari M. Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J Neurosci. 2002 May 15; 22(10):3921-8. PMID: 12019311.
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    104. Wang GJ, Deng HY, Maier CM, Sun GH, Yenari M. Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke. Neuroscience. 2002; 114(4):1081-90. PMID: 12379261.
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    105. Kelly S, Yenari M. Neuroprotection: heat shock proteins. Curr Med Res Opin. 2002; 18 Suppl 2:s55-60. PMID: 12365831.
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    106. Xu L, Yenari M, Steinberg GK, Giffard RG. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab. 2002 Jan; 22(1):21-8. PMID: 11807390.
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    107. Yenari M. Heat shock proteins and neuroprotection. Adv Exp Med Biol. 2002; 513:281-99. PMID: 12575825.
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    108. Yenari M, Iwayama S, Cheng D, Sun GH, Fujimura M, Morita-Fujimura Y, Chan PH, Steinberg GK. Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke. J Cereb Blood Flow Metab. 2002 Jan; 22(1):29-38. PMID: 11807391.
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    109. Hoehn B, Ringer TM, Xu L, Giffard RG, Sapolsky RM, Steinberg GK, Yenari M. Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J Cereb Blood Flow Metab. 2001 Nov; 21(11):1303-9. PMID: 11702045.
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    110. Zhang Z, Sobel RA, Cheng D, Steinberg GK, Yenari M. Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia. Brain Res Mol Brain Res. 2001 Nov 1; 95(1-2):75-85. PMID: 11687278.
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    111. Ringer TM, Neumann-Haefelin T, Sobel RA, Moseley ME, Yenari M. Reversal of early diffusion-weighted magnetic resonance imaging abnormalities does not necessarily reflect tissue salvage in experimental cerebral ischemia. Stroke. 2001 Oct; 32(10):2362-9. PMID: 11588327.
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    112. Yenari M, Dumas TC, Sapolsky RM, Steinberg GK. Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors. Neurol Res. 2001 Jul; 23(5):543-52. PMID: 11474812.
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    113. Lee JE, Yenari M, Sun GH, Xu L, Emond MR, Cheng D, Steinberg GK, Giffard RG. Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions. Exp Neurol. 2001 Jul; 170(1):129-39. PMID: 11421590.
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    114. Yenari M, Dumas TC, Sapolsky RM, Steinberg GK. Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors. Ann N Y Acad Sci. 2001 Jun; 939:340-57. PMID: 11462790.
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    115. Phillips RG, Monje ML, Giuli LC, Meier TJ, Yenari M, Kunis D, Sapolsky RM. Gene therapy effectiveness differs for neuronal survival and behavioral performance. Gene Ther. 2001 Apr; 8(8):579-85. PMID: 11320403.
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    116. Yenari M, Minami M, Sun GH, Meier TJ, Kunis DM, McLaughlin JR, Ho DY, Sapolsky RM, Steinberg GK. Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia. Stroke. 2001 Apr; 32(4):1028-35. PMID: 11283407.
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    117. Neumann-Haefelin T, Kastrup A, de Crespigny A, Ringer TM, Sun GH, Yenari M, Moseley ME. MRI of subacute hemorrhagic transformation in the rat suture occlusion model. Neuroreport. 2001 Feb 12; 12(2):309-11. PMID: 11209940.
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    118. Yenari M, Giffard RG. Ischemic vulnerability of primary murine microglial cultures. Neurosci Lett. 2001 Jan 26; 298(1):5-8. PMID: 11154822.
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    119. Yenari M, Sun GH, Kunis DM, Onley D, Vexler V. L-selectin inhibition does not reduce injury in a rabbit model of transient focal cerebral ischemia. Neurol Res. 2001 Jan; 23(1):72-8. PMID: 11210435.
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    120. Maier CM, Sun GH, Kunis D, Yenari M, Steinberg GK. Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size. J Neurosurg. 2001 Jan; 94(1):90-6. PMID: 11147904.
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    121. Yenari M, Onley D, Hedehus M, deCrespigny A, Sun GH, Moseley ME, Steinberg GK. Diffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia. Brain Res. 2000 Dec 8; 885(2):208-19. PMID: 11102575.
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    122. D'Arceuil H, Rhine W, de Crespigny A, Yenari M, Tait JF, Strauss WH, Engelhorn T, Kastrup A, Moseley M, Blankenberg FG. 99mTc annexin V imaging of neonatal hypoxic brain injury. Stroke. 2000 Nov; 31(11):2692-700. PMID: 11062296.
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    123. Neumann-Haefelin T, Kastrup A, de Crespigny A, Yenari M, Ringer T, Sun GH, Moseley ME. Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation. Stroke. 2000 Aug; 31(8):1965-72; discussion 1972-3. PMID: 10926965.
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    124. Yenari M, Giffard RG, Sapolsky RM, Steinberg GK. The neuroprotective potential of heat shock protein 70 (HSP70). Mol Med Today. 1999 Dec; 5(12):525-31. PMID: 10562718.
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    125. Tong DC, Albers GW, Yenari M, Marks MP. A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage. Stroke. 1999 Sep; 30(9):1974-5. PMID: 10471453.
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    126. Lansberg MG, Tong DC, Norbash AM, Yenari M, Moseley ME. Intra-arterial rtPA treatment of stroke assessed by diffusion- and perfusion-weighted MRI. Stroke. 1999 Mar; 30(3):678-80. PMID: 10066870.
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    127. Maier CM, Ahern Kv, Cheng ML, Lee JE, Yenari M, Steinberg GK. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: effects on neurologic outcome, infarct size, apoptosis, and inflammation. Stroke. 1998 Oct; 29(10):2171-80. PMID: 9756600.
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    128. Yenari M, Fink SL, Sun GH, Chang LK, Patel MK, Kunis DM, Onley D, Ho DY, Sapolsky RM, Steinberg GK. Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Ann Neurol. 1998 Oct; 44(4):584-91. PMID: 9778256.
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    129. Yenari M, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Exp Neurol. 1998 Oct; 153(2):223-33. PMID: 9784282.
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    130. Yenari M, Lee LK, Beaulieu C, Sun GH, Kunis D, Chang D, Albers GW, Moseley ME, Steinberg GK. Thrombolysis with reteplase, an unglycosylated plasminogen activator variant, in experimental embolic stroke. J Stroke Cerebrovasc Dis. 1998 May-Jun; 7(3):179-86. PMID: 17895078.
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    131. Tong DC, Yenari M, Albers GW, O'Brien M, Marks MP, Moseley ME. Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke. Neurology. 1998 Apr; 50(4):864-70. PMID: 9566364.
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    132. Adams HP, Yenari M, McDowell FH, Yonas H. Editorial commentary. J Stroke Cerebrovasc Dis. 1998 Mar-Apr; 7(2):i-ii. PMID: 17895064.
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    133. Yenari M, Bell TE, Kotake AN, Powell M, Steinberg GK. Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients. Clin Neuropharmacol. 1998 Jan-Feb; 21(1):28-34. PMID: 9579282.
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    134. Perez-Pinzon MA, Yenari M, Sun GH, Kunis DM, Steinberg GK. SNX-111, a novel, presynaptic N-type calcium channel antagonist, is neuroprotective against focal cerebral ischemia in rabbits. J Neurol Sci. 1997 Dec 9; 153(1):25-31. PMID: 9455974.
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    135. Yenari M, Beaulieu C, Steinberg GK, Moseley ME. Diffusion-weighted magnetic resonance imaging characteristics of hemorrhagic transformation in experimental embolic stroke. J Neuroimaging. 1997 Oct; 7(4):227-31. PMID: 9344005.
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    136. Yenari M, de Crespigny A, Palmer JT, Roberts S, Schrier SL, Albers GW, Moseley ME, Steinberg GK. Improved perfusion with rt-PA and hirulog in a rabbit model of embolic stroke. J Cereb Blood Flow Metab. 1997 Apr; 17(4):401-11. PMID: 9143222.
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    137. Tong DC, Yenari M, Albers GW. Intravenous thrombolytic therapy in acute stroke. Vasc Med. 1997; 2(1):51-60. PMID: 9546949.
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    138. Yenari M, Palmer JT, Sun GH, de Crespigny A, Mosely ME, Steinberg GK. Time-course and treatment response with SNX-111, an N-type calcium channel blocker, in a rodent model of focal cerebral ischemia using diffusion-weighted MRI. Brain Res. 1996 Nov 11; 739(1-2):36-45. PMID: 8955922.
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    139. Steinberg GK, Bell TE, Yenari M. Dose escalation safety and tolerance study of the N-methyl-D-aspartate antagonist dextromethorphan in neurosurgery patients. J Neurosurg. 1996 May; 84(5):860-6. PMID: 8622162.
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    140. Hart RG, Boop BS, Tong DC, Yenari M, Albers GW. Safety of heparin in acute ischemic stroke. Neurology. 1996 Feb; 46(2):589; author reply 589-91. PMID: 8614549.
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    141. Moseley ME, Butts K, Yenari M, Marks M, de Crespigny A. Clinical aspects of DWI. NMR Biomed. 1995 Nov-Dec; 8(7-8):387-96. PMID: 8739275.
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    142. Yenari M, Palmer JT, Bracci PM, Steinberg GK. Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent. Thromb Res. 1995 Mar 1; 77(5):475-81. PMID: 7778062.
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