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Yeyi Zhu, PhD

Title(s)Assistant Professor, Epidemiology & Biostatistics
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Fudan University, Shanghai, ChinaBS07/2008Biological Sciences
    The University of Texas at Austin, Austin, TXMS08/2012Statistics
    The University of Texas at Austin, Austin, TXPhD05/2014Nutritional Epidemiology
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MDPostdoctoral fellowship06/2016Nutritional and Environmental Epidemiology
    Collapse Awards and Honors
    Society for Epidemiologic Research2018  - 2019President for Students and Postdocs Early Career Committee
    American Society for Nutrition2015  - 2018 Publications Management Committee
    National Institutes of Health 2016NIH Fellows Award for Research Excellence
    The Epidemiology Congress of the Americas 2016The Epidemiology Congress of the Americas Russell Kirby Travel Scholarship
    Society for Pediatric and Perinatal Epidemiologic Research2016Society for Pediatric and Perinatal Epidemiologic Research Travel Award
    American Heart/Stroke Association 2016 EPI/lifestyle Early Investigator Travel Award
    National Institutes of Health 2015NIH Fellows Award for Research Excellence
    Eunice Kennedy Shriver National Institute of Child Health and Human Development2014  - 2016Intramural Research Training Award

    Collapse Overview 
    Collapse Overview
    Dr. Zhu’s research has been focusing on the interface of disease etiology and prevention strategies in women’s and children’s cardiometabolic health. She has sought to develop an interdisciplinary research portfolio focusing on disease etiology and prevention strategies to inform upstream prevention and interrupt the vicious intergenerational cycle of obesity, diabetes, and related comorbidities across the lifespan. Dr. Zhu has conducted NIH-funded research to examine the intergenerational associations of maternal hyperglycemia and environmental exposures (i.e., diet, nutrition, and endocrine disrupter chemicals) during pregnancy in relation to metabolic impairments at birth, during childhood, and in later life among the offspring.

    Dr. Zhu’s current work also capitalizes on rich resources of real-world clinical data available at Kaiser Permanente Northern California (KPNC) to advance research on strategies for upstream prevention and disparities reduction in cardiometabolic disorders among women and children. She applies predictive analytics to develop models to predict pregnancy complications and treatment modalities in order to inform risk-based models of care in real-world health care settings. Using the unique, universal nurse-managed supplemental care program by KPNC Regional Perinatal Service Center serving women with GDM, Dr. Zhu sought to examine racial/ethnic disparities in glycemic control. Most recently, Dr. Zhu has been examining the associations between candidate and untargeted metabolites in early to mid-pregnancy and risk of fetal growth extremes and infant growth trajectories from 0-2 years (PI: Zhu; NIDDK K01DK120807). Findings may also inform the ability of using metabolomics in improving objective dietary assessment and advancing the field of precision nutrition.

    Collapse Research 
    Collapse Research Activities and Funding
    Fetal Programming of Growth and Obesity: A Metabolomics Approach
    NIH K01DK120807Jul 1, 2019 - Apr 30, 2023
    Role: Principal Investigator
    Health Delivery Systems Center for Diabetes Translational Research
    NIH P30DK092924Sep 1, 2011 - Jul 30, 2021
    Role: PI on Sub-Project #8714 (Health Delivery Systems Center for Diabetes Translational Research Pilot Pr
    Role Description: PI on the project entitled "Investigation of Prevalence of and Barriers to Achieving Optimal Glycemic Control among Women with Gestational Diabetes"
    UCSF-Kaiser Building Interdisciplinary Research Careers in Women's Health Program
    NIH/NICHD K12HD052163Sep 20, 2000 - Jul 31, 2020
    Role: Awardee; BIRCWH scholar

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Featured Presentations
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lin Y, Zhu Y, Wu J, Hinkle SN, Rawal S, Han J, Weir NL, Tsai MY, Zhang C. A Prospective Study of Leukocyte Telomere Length and Risk of Gestational Diabetes in a Multiracial Cohort. Epidemiology. 2019 Nov; 30 Suppl 2:S10-S16. PMID: 31569148.
      View in: PubMed
    2. Tylavsky FA, Ferrara A, Catellier DJ, Oken E, Li X, Law A, Dabelea D, Rundle A, Gilbert-Diamond D, Hivert MF, Breton CV, Cassidy-Bushrow AE, Mueller NT, Hunt KJ, Arteaga SS, Lombo T, Mahabir S, Ruden D, Sauder K, Hedderson MM, Zhu Y, Polk S, Mihalopoulos NL, Vos M, Pyles L, Roary M, Aschner J, Karagas MR, Trasande L. Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program. Int J Obes (Lond). 2019 Oct 24. PMID: 31649277.
      View in: PubMed
    3. Zhu Y, Sidell MA, Arterburn D, Daley MF, Desai J, Fitzpatrick SL, Horberg MA, Koebnick C, McCormick E, Oshiro C, Young DR, Ferrara A. Racial/Ethnic Disparities in the Prevalence of Diabetes and Prediabetes by BMI: Patient Outcomes Research To Advance Learning (PORTAL) Multisite Cohort of Adults in the U.S. Diabetes Care. 2019 Sep 19. PMID: 31537541.
      View in: PubMed
    4. Zhu Y, Li M, Rahman ML, Hinkle SN, Wu J, Weir NL, Lin Y, Yang H, Tsai MY, Ferrara A, Zhang C. Plasma phospholipid n-3 and n-6 polyunsaturated fatty acids in relation to cardiometabolic markers and gestational diabetes: A longitudinal study within the prospective NICHD Fetal Growth Studies. PLoS Med. 2019 Sep; 16(9):e1002910. PMID: 31518348.
      View in: PubMed
    5. Hinkle SN, Rawal S, Bjerregaard AA, Halldorsson TI, Li M, Ley SH, Wu J, Zhu Y, Chen L, Liu A, Grunnet LG, Rahman ML, Kampmann FB, Mills JL, Olsen SF, Zhang C. A prospective study of artificially sweetened beverage intake and cardiometabolic health among women at high risk. Am J Clin Nutr. 2019 Jun 07. PMID: 31172169.
      View in: PubMed
    6. Zhu Y, Hedderson MM, Sridhar S, Xu F, Feng J, Ferrara A. Poor diet quality in pregnancy is associated with increased risk of excess fetal growth: a prospective multi-racial/ethnic cohort study. Int J Epidemiol. 2019 04 01; 48(2):423-432. PMID: 30590563.
      View in: PubMed
    7. Mangini LD, Hayward MD, Zhu Y, Dong Y, Forman MR. Timing of household food insecurity exposures and asthma in a cohort of US school-aged children. BMJ Open. 2019 02 22; 8(11):e021683. PMID: 30798285.
      View in: PubMed
    8. Zhu Y, Hedderson MM, Quesenberry CP, Feng J, Ferrara A. Central Obesity Increases the Risk of Gestational Diabetes Partially Through Increasing Insulin Resistance. Obesity (Silver Spring). 2019 01; 27(1):152-160. PMID: 30461219.
      View in: PubMed
    9. Francis EC, Hinkle SN, Song Y, Rawal S, Donnelly SR, Zhu Y, Chen L, Zhang C. Longitudinal Maternal Vitamin D Status during Pregnancy Is Associated with Neonatal Anthropometric Measures. Nutrients. 2018 Nov 02; 10(11). PMID: 30400155.
      View in: PubMed
    10. Gadgil MD, Ehrlich SF, Zhu Y, Brown SD, Hedderson MM, Crites Y, Ferrara A. Dietary Quality and Glycemic Control Among Women with Gestational Diabetes Mellitus. J Womens Health (Larchmt). 2019 Feb; 28(2):178-184. PMID: 30376391.
      View in: PubMed
    11. Zhu Y, Hernandez LM, Dong Y, Himes JH, Caulfield LE, Kerver JM, Arab L, Voss P, Hirschfeld S, Forman MR. Weight estimation among multi-racial/ethnic infants and children aged 0-5·9 years in the USA: simple tools for a critical measure. Public Health Nutr. 2019 01; 22(1):147-156. PMID: 30333072.
      View in: PubMed
    12. Zhu Y, Ferrara A, Forman MR. Omega 3 polyunsaturated fatty acids and healthy ageing. BMJ. 2018 10 17; 363:k4263. PMID: 30333101.
      View in: PubMed
    13. Zhu Y, Hedderson MM, Quesenberry CP, Feng J, Ferrara A. Liver Enzymes in Early to Mid-pregnancy, Insulin Resistance, and Gestational Diabetes Risk: A Longitudinal Analysis. Front Endocrinol (Lausanne). 2018; 9:581. PMID: 30333792.
      View in: PubMed
    14. Badon SE, Zhu Y, Sridhar SB, Xu F, Lee C, Ehrlich SF, Quesenberry CP, Hedderson MM. A Pre-Pregnancy Biomarker Risk Score Improves Prediction of Future Gestational Diabetes. J Endocr Soc. 2018 Oct 01; 2(10):1158-1169. PMID: 30302420.
      View in: PubMed
    15. Rawal S, Tsai MY, Hinkle SN, Zhu Y, Bao W, Lin Y, Panuganti P, Albert PS, Ma RCW, Zhang C. A Longitudinal Study of Thyroid Markers Across Pregnancy and the Risk of Gestational Diabetes. J Clin Endocrinol Metab. 2018 07 01; 103(7):2447-2456. PMID: 29889229.
      View in: PubMed
    16. Zhu Y, Tsai MY, Sun Q, Hinkle SN, Rawal S, Mendola P, Ferrara A, Albert PS, Zhang C. A prospective and longitudinal study of plasma phospholipid saturated fatty acid profile in relation to cardiometabolic biomarkers and the risk of gestational diabetes. Am J Clin Nutr. 2018 06 01; 107(6):1017-1026. PMID: 29868913.
      View in: PubMed
    17. Rawal S, Olsen SF, Grunnet LG, Ma RC, Hinkle SN, Granström C, Wu J, Yeung E, Mills JL, Zhu Y, Bao W, Ley SH, Hu FB, Damm P, Vaag A, Tsai MY, Zhang C. Gestational Diabetes Mellitus and Renal Function: A Prospective Study With 9- to 16-Year Follow-up After Pregnancy. Diabetes Care. 2018 07; 41(7):1378-1384. PMID: 29728364.
      View in: PubMed
    18. Hedderson MM, Brown SD, Ehrlich SF, Tsai AL, Zhu Y, Quesenberry CP, Crites Y, Ferrara A. A Tailored Letter Based on Electronic Health Record Data Improves Gestational Weight Gain Among Women With Gestational Diabetes Mellitus: The Gestational Diabetes' Effects on Moms (GEM) Cluster-Randomized Controlled Trial. Diabetes Care. 2018 07; 41(7):1370-1377. PMID: 29669736.
      View in: PubMed
    19. Ha S, Liu D, Zhu Y, Sherman S, Mendola P. Acute Associations Between Outdoor Temperature and Premature Rupture of Membranes. Epidemiology. 2018 03; 29(2):175-182. PMID: 29087988.
      View in: PubMed
    20. Li S, Zhu Y, Yeung E, Chavarro JE, Yuan C, Field AE, Missmer SA, Mills JL, Hu FB, Zhang C. Offspring risk of obesity in childhood, adolescence and adulthood in relation to gestational diabetes mellitus: a sex-specific association. Int J Epidemiol. 2017 12 01; 46(6):2104. PMID: 29025133.
      View in: PubMed
    21. Li S, Zhu Y, Yeung E, Chavarro JE, Yuan C, Field AE, Missmer SA, Mills JL, Hu FB, Zhang C. Offspring risk of obesity in childhood, adolescence and adulthood in relation to gestational diabetes mellitus: a sex-specific association. Int J Epidemiol. 2017 10 01; 46(5):1533-1541. PMID: 29024955.
      View in: PubMed
    22. Zhu Y, Olsen SF, Mendola P, Halldorsson TI, Rawal S, Hinkle SN, Yeung EH, Chavarro JE, Grunnet LG, Granström C, Bjerregaard AA, Hu FB, Zhang C. Maternal consumption of artificially sweetened beverages during pregnancy, and offspring growth through 7 years of age: a prospective cohort study. Int J Epidemiol. 2017 10 01; 46(5):1499-1508. PMID: 28586472.
      View in: PubMed
    23. Bao W, Dar S, Zhu Y, Wu J, Rawal S, Li S, Weir NL, Tsai MY, Zhang C. Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes. 2018 Jun; 10(6):487-495. PMID: 28436169.
      View in: PubMed
    24. Hinkle SN, Rawal S, Zhu Y, Grewal J, Albert PS, Zhang C. Validation of Self-reported Diagnosis of Gestational Diabetes at 6-weeks Postpartum. Epidemiology. 2017 09; 28(5):747-752. PMID: 28570385.
      View in: PubMed
    25. Zhu Y, Zhang C, Liu D, Ha S, Kim SS, Pollack A, Mendola P. Ambient Air Pollution and Risk of Gestational Hypertension. Am J Epidemiol. 2017 Aug 01; 186(3):334-343. PMID: 28472208.
      View in: PubMed
    26. Mendola P, Ha S, Pollack AZ, Zhu Y, Seeni I, Kim SS, Sherman S, Liu D. Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth. Int J Environ Res Public Health. 2017 07 06; 14(7). PMID: 28684711.
      View in: PubMed
    27. Ha S, Liu D, Zhu Y, Soo Kim S, Sherman S, Grantz KL, Mendola P. Ambient Temperature and Stillbirth: A Multi-Center Retrospective Cohort Study. Environ Health Perspect. 2017 06 22; 125(6):067011. PMID: 28650842.
      View in: PubMed
    28. Zhu Y, Olsen SF, Mendola P, Halldorsson TI, Yeung EH, Granström C, Bjerregaard AA, Wu J, Rawal S, Chavarro JE, Hu FB, Zhang C. Maternal dietary intakes of refined grains during pregnancy and growth through the first 7 y of life among children born to women with gestational diabetes. Am J Clin Nutr. 2017 Jul; 106(1):96-104. PMID: 28592607.
      View in: PubMed
    29. Zhu Y, Hedderson MM, Feng J, Mevi AA, Ferrara A. The Pregnancy Environment and Lifestyle Study (PETALS): a population-based longitudinal multi-racial birth cohort. BMC Pregnancy Childbirth. 2017 04 17; 17(1):122. PMID: 28415965.
      View in: PubMed
    30. Kim SS, Mendola P, Zhu Y, Hwang BS, Grantz KL. Spontaneous and indicated preterm delivery risk is increased among overweight and obese women without prepregnancy chronic disease. BJOG. 2017 Oct; 124(11):1708-1716. PMID: 28236376.
      View in: PubMed
    31. Ha S, Zhu Y, Liu D, Sherman S, Mendola P. Ambient temperature and air quality in relation to small for gestational age and term low birthweight. Environ Res. 2017 05; 155:394-400. PMID: 28258738.
      View in: PubMed
    32. Rawal S, Hinkle SN, Zhu Y, Albert PS, Zhang C. A longitudinal study of sleep duration in pregnancy and subsequent risk of gestational diabetes: findings from a prospective, multiracial cohort. Am J Obstet Gynecol. 2017 04; 216(4):399.e1-399.e8. PMID: 27939328.
      View in: PubMed
    33. Wallace ME, Mendola P, Kim SS, Epps N, Chen Z, Smarr M, Hinkle SN, Zhu Y, Grantz KL. Racial/ethnic differences in preterm perinatal outcomes. Am J Obstet Gynecol. 2017 Mar; 216(3):306.e1-306.e12. PMID: 27865977.
      View in: PubMed
    34. Rawal S, Hinkle SN, Bao W, Zhu Y, Grewal J, Albert PS, Weir NL, Tsai MY, Zhang C. A longitudinal study of iron status during pregnancy and the risk of gestational diabetes: findings from a prospective, multiracial cohort. Diabetologia. 2017 02; 60(2):249-257. PMID: 27830277.
      View in: PubMed
    35. Mendola P, Sundaram R, Louis GMB, Sun L, Wallace ME, Smarr MM, Sherman S, Zhu Y, Ying Q, Liu D. Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility. Sci Total Environ. 2017 Jan 15; 576:172-177. PMID: 27783935.
      View in: PubMed
    36. Hinkle SN, Buck Louis GM, Rawal S, Zhu Y, Albert PS, Zhang C. A longitudinal study of depression and gestational diabetes in pregnancy and the postpartum period. Diabetologia. 2016 12; 59(12):2594-2602. PMID: 27640810.
      View in: PubMed
    37. Ha S, Liu D, Zhu Y, Kim SS, Sherman S, Mendola P. Ambient Temperature and Early Delivery of Singleton Pregnancies. Environ Health Perspect. 2017 03; 125(3):453-459. PMID: 27580125.
      View in: PubMed
    38. Zhu Y, Mendola P, Albert PS, Bao W, Hinkle SN, Tsai MY, Zhang C. Insulin-Like Growth Factor Axis and Gestational Diabetes Mellitus: A Longitudinal Study in a Multiracial Cohort. Diabetes. 2016 Nov; 65(11):3495-3504. PMID: 27468747.
      View in: PubMed
    39. Kim SS, Zhu Y, Grantz KL, Hinkle SN, Chen Z, Wallace ME, Smarr MM, Epps NM, Mendola P. Obstetric and Neonatal Risks Among Obese Women Without Chronic Disease. Obstet Gynecol. 2016 07; 128(1):104-12. PMID: 27275800.
      View in: PubMed
    40. Wallace ME, Grantz KL, Liu D, Zhu Y, Kim SS, Mendola P. Exposure to Ambient Air Pollution and Premature Rupture of Membranes. Am J Epidemiol. 2016 06 15; 183(12):1114-21. PMID: 27188941.
      View in: PubMed
    41. Li S, Zhu Y, Chavarro JE, Bao W, Tobias DK, Ley SH, Forman JP, Liu A, Mills J, Bowers K, Strøm M, Hansen S, Hu FB, Zhang C. Healthful Dietary Patterns and the Risk of Hypertension Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study. Hypertension. 2016 06; 67(6):1157-65. PMID: 27091899.
      View in: PubMed
    42. Zhu Y, Hernandez LM, Mueller P, Dong Y, Hirschfeld S, Forman MR. Predictive Models for Characterizing Disparities in Exclusive Breastfeeding Performance in a Multi-ethnic Population in the US. Matern Child Health J. 2016 Feb; 20(2):398-407. PMID: 26515468.
      View in: PubMed
    43. Zhu Y, Olsen SF, Mendola P, Yeung EH, Vaag A, Bowers K, Liu A, Bao W, Li S, Madsen C, Grunnet LG, Granström C, Hansen S, Martin K, Chavarro JE, Hu FB, Langhoff-Roos J, Damm P, Zhang C. Growth and obesity through the first 7 y of life in association with levels of maternal glycemia during pregnancy: a prospective cohort study. Am J Clin Nutr. 2016 Mar; 103(3):794-800. PMID: 26817507.
      View in: PubMed
    44. Chen L, Li S, He C, Zhu Y, Buck Louis GM, Yeung E, Hu FB, Zhang C. Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women. Diabetes Care. 2016 Mar; 39(3):469-71. PMID: 26813668.
      View in: PubMed
    45. Zhu Y, Zhang C. Prevalence of Gestational Diabetes and Risk of Progression to Type 2 Diabetes: a Global Perspective. Curr Diab Rep. 2016 Jan; 16(1):7. PMID: 26742932.
      View in: PubMed
    46. Bao W, Li S, Chavarro JE, Tobias DK, Zhu Y, Hu FB, Zhang C. Low Carbohydrate-Diet Scores and Long-term Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes Care. 2016 Jan; 39(1):43-9. PMID: 26577416.
      View in: PubMed
    47. Zhu Y, Zhang C, Liu D, Grantz KL, Wallace M, Mendola P. Maternal ambient air pollution exposure preconception and during early gestation and offspring congenital orofacial defects. Environ Res. 2015 Jul; 140:714-20. PMID: 26099933.
      View in: PubMed
    48. Zhu Y, Hernandez LM, Dong Y, Himes JH, Hirschfeld S, Forman MR. Longer breastfeeding duration reduces the positive relationships among gestational weight gain, birth weight and childhood anthropometrics. J Epidemiol Community Health. 2015 Jul; 69(7):632-8. PMID: 25680365.
      View in: PubMed
    49. Forman MR, Zhu Y, Hernandez LM, Himes JH, Dong Y, Danish RK, James KE, Caulfield LE, Kerver JM, Arab L, Voss P, Hale DE, Kanafani N, Hirschfeld S. Arm span and ulnar length are reliable and accurate estimates of recumbent length and height in a multiethnic population of infants and children under 6 years of age. J Nutr. 2014 Sep; 144(9):1480-7. PMID: 25031329.
      View in: PubMed
    50. Zhu Y, Hernandez LM, Mueller P, Dong Y, Forman MR. Data Acquisition and Preprocessing in Studies on Humans: What Is Not Taught in Statistics Classes? Am Stat. 2013; 67(4):235-241. PMID: 24511148.
      View in: PubMed