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Lauren Weiss, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentPsychiatry
Address401 Parnassus Ave, LangPorter
San Francisco CA 94143
Phone415-476-7650
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    Collapse Overview 
    Collapse Overview
    My laboratory focuses on understanding the genetic architecture of autism. We are working with genome-wide genetic data to identify additional susceptibility loci, the genetic mechanisms by which DNA variants influence autism risk, and the genetic and physiological pathways these risk loci implicate. We can use rich genetic datasets to ask questions about the role for copy number vs. SNP variation, rare vs. common variation, gene-sex interaction, gene-gene interaction, and gene-environment interaction.


    We are also using human induced pluripotent stem cell (iPSC) models to study known mutations or copy number variants predisposing to autism. We will first identify the effects of genetic risk variants and then be able to ascertain whether the effects of genetic risk can be modified at the cellular level by environmental or pharmacological agents. These models will be used to test hypotheses emerging from our genetic datasets.


    Our long term goals are to use genetic tools to improve understanding, prevention, diagnosis, and treatment of autism and related traits.


    Collapse Research 
    Collapse Research Activities and Funding
    Utilizing eQTL networks to gain biological insight into multigenic CNVs
    NIH/NIMH R01MH107467Apr 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Epigenetic loss of heterozygosity in a recurrent neurodevelopmental CNV region
    NIH/NIMH R21MH105745Sep 5, 2014 - Aug 31, 2016
    Role: Co-Principal Investigator
    Dissecting Epistasis and Pleiotropy in Autism towards Personalized Medicine
    NIH DP2OD007449Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    A Sex-Specific Dissection of Autism Genetics
    NIH/NICHD R21HD065273Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Molecular analysis of a gene affecting social cognition
    NIH/NIMH F32MH077476May 7, 2007 - Apr 30, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Global Health
    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Traglia M, Bseiso D, Gusev A, Adviento B, Park DS, Mefford JA, Zaitlen N, Weiss L. Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits. Genetics. 2016 Dec 14. PMID: 27974502.
      View in: PubMed
    2. Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren RL, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Herz-Picciotto I, Fallin MD, Weiss L. Pleiotropic Mechanisms Indicated for Sex Differences in Autism. PLoS Genet. 2016 Nov; 12(11):e1006425. PMID: 27846226.
      View in: PubMed
    3. Yeh E, Weiss L. If genetic variation could talk: What genomic data may teach us about the importance of gene expression regulation in the genetics of autism. Mol Cell Probes. 2016 Oct 14. PMID: 27751841.
      View in: PubMed
    4. Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss L, Rauen KA, Sobie EA, Gelb BD. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016 Sep 13; 7(3):355-69. PMID: 27569062.
      View in: PubMed
    5. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss L, Ullian EM. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 6; 36(1):142-52. PMID: 26740656.
      View in: PubMed
    6. Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss L, Rowitch DH, Ullian EM. Dysregulation of astrocyte extracellular signaling in Costello syndrome. Sci Transl Med. 2015 May 6; 7(286):286ra66. PMID: 25947161; PMCID: PMC4474402.
    7. Maier R, Moser G, Chen GB, Ripke S, Coryell W, Potash JB, Scheftner WA, Shi J, Weissman MM, Hultman CM, Landén M, Levinson DF, Kendler KS, Smoller JW, Wray NR, Lee SH. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. Am J Hum Genet. 2015 Feb 5; 96(2):283-94. PMID: 25640677; PMCID: PMC4320268.
    8. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci. 2015 Feb; 18(2):199-209. PMID: 25599223; PMCID: PMC4378867.
    9. Desachy G, Croen LA, Torres AR, Kharrazi M, Delorenze GN, Windham GC, Yoshida CK, Weiss L. Increased female autosomal burden of rare copy number variants in human populations and in autism families. Mol Psychiatry. 2015 Feb; 20(2):170-5. PMID: 25582617.
      View in: PubMed
    10. Poultney CS, Samocha K, Kou Y, Liu L, Walker S, Klei L, Kosmicki J, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Crawford EL, Crooks L, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Jimenez Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei J, Lehtimäki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Owen MJ, Ozaki N, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnström K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Rüther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Wang LS, Weiss L, Jeremy Willsey A, Yu TW, Yuen RK, Palotie A, Schellenberg GD, Sklar P, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Roeder K. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature. 2014 Nov 13; 515(7526):209-15. PMID: 25363760; PMCID: PMC4402723.
    11. Bershteyn M, Hayashi Y, Desachy G, Hsiao EC, Sami S, Tsang KM, Weiss L, Kriegstein AR, Yamanaka S, Wynshaw-Boris A. Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells. Nature. 2014 Mar 6; 507(7490):99-103. PMID: 24413397; PMCID: PMC4030630.
    12. Tsang KM, Croen LA, Torres AR, Kharrazi M, Delorenze GN, Windham GC, Yoshida CK, Zerbo O, Weiss L. A genome-wide survey of transgenerational genetic effects in autism. PLoS One. 2013; 8(10):e76978. PMID: 24204716; PMCID: PMC3811986.
    13. Adviento B, Corbin IL, Widjaja F, Desachy G, Enrique N, Rosser T, Risi S, Marco EJ, Hendren RL, Bearden CE, Rauen KA, Weiss L. Autism traits in the RASopathies. J Med Genet. 2014 Jan; 51(1):10-20. PMID: 24101678; PMCID: PMC4230531.
    14. Abrahams BS, Arking DE, Campbell DB, Mefford HC, Morrow EM, Weiss L, Menashe I, Wadkins T, Banerjee-Basu S, Packer A. SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs). Mol Autism. 2013; 4(1):36. PMID: 24090431; PMCID: PMC3851189.
    15. Martin PM, Yang X, Robin N, Lam E, Rabinowitz JS, Erdman CA, Quinn J, Weiss L, Hamilton SP, Kwok PY, Moon RT, Cheyette BN. A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation. Transl Psychiatry. 2013; 3:e301. PMID: 24002087; PMCID: PMC3784764.
    16. Cheng Y, Quinn JF, Weiss L. An eQTL mapping approach reveals that rare variants in the SEMA5A regulatory network impact autism risk. Hum Mol Genet. 2013 Jul 15; 22(14):2960-72. PMID: 23575222; PMCID: PMC3690972.
    17. Goodwin AF, Oberoi S, Landan M, Charles C, Groth J, Martinez A, Fairley C, Weiss L, Tidyman WE, Klein OD, Rauen KA. Craniofacial and dental development in cardio-facio-cutaneous syndrome: the importance of Ras signaling homeostasis. Clin Genet. 2013 Jun; 83(6):539-44. PMID: 22946697; PMCID: PMC4115672.
    18. Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012; 8(3):e1002592. PMID: 22457638; PMCID: PMC3310790.
    19. Weiss L. Autism genetics: emerging data from genome-wide copy-number and single nucleotide polymorphism scans. Expert Rev Mol Diagn. 2009 Nov; 9(8):795-803. PMID: 19895225.
      View in: PubMed
    20. Weiss L, Arking DE, Daly MJ, Chakravarti A. A genome-wide linkage and association scan reveals novel loci for autism. Nature. 2009 Oct 8; 461(7265):802-8. PMID: 19812673; PMCID: PMC2772655.
    21. Weiss L. New insights into genomic variation in health and disease. Genome Med. 2009; 1(4):41. PMID: 19435489; PMCID: PMC2684662.
    22. Blaya C, Moorjani P, Salum GA, Gonçalves L, Weiss L, Leistner-Segal S, Manfro GG, Smoller JW. Preliminary evidence of association between EFHC2, a gene implicated in fear recognition, and harm avoidance. Neurosci Lett. 2009 Mar 6; 452(1):84-6. PMID: 19429002.
      View in: PubMed
    23. Miller DT, Shen Y, Weiss L, Korn J, Anselm I, Bridgemohan C, Cox GF, Dickinson H, Gentile J, Harris DJ, Hegde V, Hundley R, Khwaja O, Kothare S, Luedke C, Nasir R, Poduri A, Prasad K, Raffalli P, Reinhard A, Smith SE, Sobeih MM, Soul JS, Stoler J, Takeoka M, Tan WH, Thakuria J, Wolff R, Yusupov R, Gusella JF, Daly MJ, Wu BL. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009 Apr; 46(4):242-8. PMID: 18805830; PMCID: PMC4090085.
    24. Weiss L, Shen Y, Korn JM, Arking DE, Miller DT, Fossdal R, Saemundsen E, Stefansson H, Ferreira MA, Green T, Platt OS, Ruderfer DM, Walsh CA, Altshuler D, Chakravarti A, Tanzi RE, Stefansson K, Santangelo SL, Gusella JF, Sklar P, Wu BL, Daly MJ. Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med. 2008 Feb 14; 358(7):667-75. PMID: 18184952.
      View in: PubMed
    25. Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss L, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF. Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet. 2008 Jan; 82(1):199-207. PMID: 18179900; PMCID: PMC2253961.
    26. Thompson EE, Pan L, Ostrovnaya I, Weiss L, Gern JE, Lemanske RF, Nicolae DL, Ober C. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol. 2007 Jun; 119(6):1423-9. PMID: 17556058.
      View in: PubMed
    27. Cross S, Kim SJ, Weiss L, Delahanty RJ, Sutcliffe JS, Leventhal BL, Cook EH, Veenstra-Vanderweele J. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology. 2008 Jan; 33(2):353-60. PMID: 17406648; PMCID: PMC2739682.
    28. Weiss L, Purcell S, Waggoner S, Lawrence K, Spektor D, Daly MJ, Sklar P, Skuse D. Identification of EFHC2 as a quantitative trait locus for fear recognition in Turner syndrome. Hum Mol Genet. 2007 Jan 1; 16(1):107-13. PMID: 17164267.
      View in: PubMed
    29. Weiss L, Ober C, Cook EH. ITGB3 shows genetic and expression interaction with SLC6A4. Hum Genet. 2006 Aug; 120(1):93-100. PMID: 16721604.
      View in: PubMed
    30. Weiss L, Kosova G, Delahanty RJ, Jiang L, Cook EH, Ober C, Sutcliffe JS. Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility. Eur J Hum Genet. 2006 Aug; 14(8):923-31. PMID: 16724005.
      View in: PubMed
    31. Weiss L, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet. 2006 Feb; 38(2):218-22. PMID: 16429159.
      View in: PubMed
    32. Kurina LM, Weiss L, Graves SW, Parry R, Williams GH, Abney M, Ober C. Sex differences in the genetic basis of morning serum cortisol levels: genome-wide screen identifies two novel loci specific to women. J Clin Endocrinol Metab. 2005 Aug; 90(8):4747-52. PMID: 15941864.
      View in: PubMed
    33. Weiss L, Abney M, Parry R, Scanu AM, Cook EH, Ober C. Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample. Hum Genet. 2005 Jun; 117(1):81-7. PMID: 15834589.
      View in: PubMed
    34. Weiss L, Lester LA, Gern JE, Wolf RL, Parry R, Lemanske RF, Solway J, Ober C. Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations. Am J Respir Crit Care Med. 2005 Jul 1; 172(1):67-73. PMID: 15817799; PMCID: PMC2718448.
    35. Weiss L, Abney M, Cook EH, Ober C. Sex-specific genetic architecture of whole blood serotonin levels. Am J Hum Genet. 2005 Jan; 76(1):33-41. PMID: 15526234; PMCID: PMC1196431.
    36. Weiss L, Veenstra-Vanderweele J, Newman DL, Kim SJ, Dytch H, McPeek MS, Cheng S, Ober C, Cook EH, Abney M. Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. Eur J Hum Genet. 2004 Nov; 12(11):949-54. PMID: 15292919.
      View in: PubMed
    37. Weiss L, Escayg A, Kearney JA, Trudeau M, MacDonald BT, Mori M, Reichert J, Buxbaum JD, Meisler MH. Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Mol Psychiatry. 2003 Feb; 8(2):186-94. PMID: 12610651.
      View in: PubMed
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