Loading...

Chao Tang, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address1700 4th Street
San Francisco CA 94158
Phone415-514-4414
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    University of Chicago1982  - 1982Valentine Telegdi Prize, University of Chicago
    American Physical Society1997  - 1997Fellow, the American Physical Society
    OverseaNational Science Foundation of China2002  - 2002Overseas Chinese Young Scholars Award, National Science Foundation of China
    Troisième2003  - 2003Troisième Cycle Lecture, Lausanne, Switzerland
    Chinese Ministry of Education2003  - 2003Chang Jiang Scholar Award, Chinese Ministry of Education
    Chinese University of Hong Kong2006  - 2006Croucher Lecture, Chinese University of Hong Kong
    2011  - 2011China Thousand Talent Program

    Collapse Overview 
    Collapse Overview
    We are a Systems Biology lab. We are interested in quantitative studies of biological systems, applying and developing quantitative methods and tools to address key biological questions. We believe that an interdisciplinary approach focusing on quantitative questions at a systems level will uncover new biological principles and help us to better understand complex disease and design new therapeutic strategies. The lab has both wet and dry components. Some of our current projects include: yeast cell cycle regulation, stress response, the function and topology of biological networks, modeling cancer pathways and development, systems drug design, and theoretical issues in systems biology.


    Collapse Research 
    Collapse Research Activities and Funding
    Quantitative studies of cell cycle checkpoints and switches
    NIH/NIGMS R01GM097115Aug 8, 2011 - May 31, 2015
    Role: Principal Investigator
    Exploring Design Principles of Cellular Control Circuits
    NIH/NIGMS P50GM081879Aug 1, 2010 - Jul 31, 2018
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lu WW, Jia LX, Ni XQ, Zhao L, Chang JR, Zhang JS, Hou YL, Zhu Y, Guan YF, Yu YR, Du J, Tang CS, Qi YF. Intermedin1-53 Attenuates Abdominal Aortic Aneurysm by Inhibiting Oxidative Stress. Arterioscler Thromb Vasc Biol. 2016 Nov; 36(11):2176-2190. PMID: 27634835.
      View in: PubMed
    2. Pang XX, Bai Q, Wu F, Chen GJ, Zhang AH, Tang CS. Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice. Kidney Blood Press Res. 2016; 41(4):434-49. PMID: 27467277.
      View in: PubMed
    3. Chang JR, Guo J, Wang Y, Hou YL, Lu WW, Zhang JS, Yu YR, Xu MJ, Liu XY, Wang XJ, Guan YF, Zhu Y, Du J, Tang CS, Qi YF. Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of a-Klotho. Kidney Int. 2016 Mar; 89(3):586-600. PMID: 26880455.
      View in: PubMed
    4. Lu WW, Zhao L, Zhang JS, Hou YL, Yu YR, Jia MZ, Tang CS, Qi YF. Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase. J Hypertens. 2015 Aug; 33(8):1676-87. PMID: 26136070.
      View in: PubMed
    5. Yang H, Li N, Song LN, Wang L, Tian C, Tang CS, Du J, Li HH, Yu XH, Wang HX. Activation of NOD1 by DAP contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways. Apoptosis. 2015 Apr; 20(4):512-22. PMID: 25608996.
      View in: PubMed
    6. Ni X, Zhang J, Tang C, Qi Y. Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease. Sci China Life Sci. 2014 Aug; 57(8):781-9. PMID: 25104450.
      View in: PubMed
    7. Mao Y, Su J, Lei L, Meng L, Qi Y, Huo Y, Tang C. Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta. J Cardiovasc Med (Hagerstown). 2014 Jul; 15(7):572-8. PMID: 24914635.
      View in: PubMed
    8. Zhou H, Sun HJ, Chang JR, Ding L, Gao Q, Tang CS, Zhu GQ, Zhou YB. Cardiac sympathetic afferent reflex response to intermedin microinjection into paraventricular nucleus is mediated by nitric oxide and ?-amino butyric acid in hypertensive rats. Exp Biol Med (Maywood). 2014 Oct; 239(10):1352-9. PMID: 24872434.
      View in: PubMed
    9. Dai XY, Cai Y, Sun W, Ding Y, Wang W, Kong W, Tang C, Zhu Y, Xu MJ, Wang X. Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA. Cardiovasc Res. 2014 Feb 01; 101(2):297-305. PMID: 24253523.
      View in: PubMed
    10. Chang JR, Duan XH, Zhang BH, Teng X, Zhou YB, Liu Y, Yu YR, Zhu Y, Tang CS, Qi YF. Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway. Exp Biol Med (Maywood). 2013 Oct; 238(10):1136-46. PMID: 24006303.
      View in: PubMed
    11. Jiang HM, Wang HX, Yang H, Zeng XJ, Tang C, Du J, Li HH. Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice. Am J Hypertens. 2013 Oct; 26(10):1224-33. PMID: 23761490.
      View in: PubMed
    12. Li L, Liu D, Bu D, Chen S, Wu J, Tang C, Du J, Jin H. Brg1-dependent epigenetic control of vascular smooth muscle cell proliferation by hydrogen sulfide. Biochim Biophys Acta. 2013 Jun; 1833(6):1347-55. PMID: 23499876.
      View in: PubMed
    13. Zeng Y, Li J, Wang HX, Guo SB, Yang H, Zeng XJ, Fang Q, Tang C, Du J, Li HH. Transcriptional effects of E3 ligase atrogin-1/MAFbx on apoptosis, hypertrophy and inflammation in neonatal rat cardiomyocytes. PLoS One. 2013; 8(1):e53831. PMID: 23335977; PMCID: PMC3545877.
    14. Zheng Y, Liao F, Du JB, Tang CS, Xu GH, Geng B. [Modified methylene blue method for measurement of hydrogen sulfide level in plasma]. Sheng Li Xue Bao. 2012 Dec 25; 64(6):681-6. PMID: 23258332.
      View in: PubMed
    15. Dai XY, Cai Y, Mao DD, Qi YF, Tang C, Xu Q, Zhu Y, Xu MJ, Wang X. Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice. J Mol Cell Cardiol. 2012 Oct; 53(4):509-20. PMID: 22841663.
      View in: PubMed
    16. Zhao L, Peng DQ, Zhang J, Song JQ, Teng X, Yu YR, Tang CS, Qi YF. Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1-53 attenuating myocardial oxidative stress injury induced by ischemia/reperfusion. Peptides. 2012 Feb; 33(2):329-35. PMID: 22244813.
      View in: PubMed
    17. Wu SY, Yu YR, Cai Y, Jia LX, Wang X, Xiao CS, Tang CS, Qi YF. Endogenous aldosterone is involved in vascular calcification in rat. Exp Biol Med (Maywood). 2012 Jan; 237(1):31-7. PMID: 22185918.
      View in: PubMed
    18. Zheng M, Zeng Q, Shi XQ, Zhao J, Tang C, Sun NL, Geng B. Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension. Chin Med J (Engl). 2011 Nov; 124(22):3693-701. PMID: 22340226.
      View in: PubMed
    19. Duan XH, Qu XX, Chang JR, Qi YF, Tang CS. [The endocrine function of the skeleton]. Sheng Li Ke Xue Jin Zhan. 2010 Aug; 41(4):248-55. PMID: 21416939.
      View in: PubMed
    20. Pan CS, Zhang J, Yu F, Teng X, Cao CQ, Wu W, Tang CS, Qi YF. Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice. Peptides. 2010 Jun; 31(6):1150-8. PMID: 20332006.
      View in: PubMed
    21. Pan CS, Teng X, Zhang J, Cai Y, Zhao J, Wu W, Wang X, Tang CS, Qi YF. Apelin antagonizes myocardial impairment in sepsis. J Card Fail. 2010 Jul; 16(7):609-17. PMID: 20610237.
      View in: PubMed
    22. Cai Y, Xu MJ, Teng X, Zhou YB, Chen L, Zhu Y, Wang X, Tang CS, Qi YF. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. Cardiovasc Res. 2010 Mar 01; 85(4):864-73. PMID: 19910445.
      View in: PubMed
    23. Song JQ, Teng X, Cai Y, Tang CS, Qi YF. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis. 2009 Nov; 14(11):1299-307. PMID: 19757065.
      View in: PubMed
    24. Song JQ, Teng X, Cai Y, Tang CS, Qi YF. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis. 2009 Sep; 14(9):1061-9. PMID: 19634012.
      View in: PubMed
    25. Ma W, Trusina A, El-Samad H, Lim WA, Tang C. Defining network topologies that can achieve biochemical adaptation. Cell. 2009 Aug 21; 138(4):760-73. PMID: 19703401; PMCID: PMC3068210.
    26. Zhou YB, Jin SJ, Cai Y, Teng X, Chen L, Tang CS, Qi YF. Lanthanum acetate inhibits vascular calcification induced by vitamin D3 plus nicotine in rats. Exp Biol Med (Maywood). 2009 Aug; 234(8):908-17. PMID: 19546357.
      View in: PubMed
    27. Trusina A, Papa FR, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. PMID: 19075238.
      View in: PubMed
    28. Li X, Du J, Jin H, Geng B, Tang C. Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Heart Vessels. 2008 Nov; 23(6):409-19. PMID: 19037589.
      View in: PubMed
    29. Yang K, Bai H, Ouyang Q, Lai L, Tang C. Finding multiple target optimal intervention in disease-related molecular network. Mol Syst Biol. 2008; 4:228. PMID: 18985027; PMCID: PMC2673713.
    30. Wu R, Yao WZ, Chen YH, Geng B, Tang C. [Plasma level of endogenous hydrogen sulfide in patients with acute asthma]. Beijing Da Xue Xue Bao. 2008 Oct 18; 40(5):505-8. PMID: 18931714.
      View in: PubMed
    31. Jin HF, Liang C, Liang JM, Tang CS, DU JB. [Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008 Aug 19; 88(32):2235-9. PMID: 19087668.
      View in: PubMed
    32. Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008 Jul 04; 321(5885):126-9. PMID: 18599789; PMCID: PMC2728800.
    33. Liu XH, Tang C. [The paracrine and autocrine of stem cells: a new frontier of basic and clinical research]. Sheng Li Ke Xue Jin Zhan. 2008 Jul; 39(3):196-202. PMID: 18819485.
      View in: PubMed
    34. Kloster M, Tang C. SCUMBLE: a method for systematic and accurate detection of codon usage bias by maximum likelihood estimation. Nucleic Acids Res. 2008 Jun; 36(11):3819-27. PMID: 18495752; PMCID: PMC2441815.
    35. Zhang Q, Jin H, Wang L, Chen J, Tang C, Du J. Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents. Med Sci Monit. 2008 Apr; 14(4):CR199-203. PMID: 18376348.
      View in: PubMed
    36. Chen XY, Liu XM, Feng LL, Tang C. [Changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Apr; 30(2):131-5. PMID: 18505110.
      View in: PubMed
    37. Wu R, Yao WZ, Chen YH, Geng B, Lu M, Tang C. [The regulatory effect of endogenous hydrogen sulfide on acute asthma]. Zhonghua Jie He He Hu Xi Za Zhi. 2007 Jul; 30(7):522-6. PMID: 17961407.
      View in: PubMed
    38. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9018-23. PMID: 17495027; PMCID: PMC1885620.
    39. Lau KY, Ganguli S, Tang C. Function constrains network architecture and dynamics: a case study on the yeast cell cycle Boolean network. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May; 75(5 Pt 1):051907. PMID: 17677098.
      View in: PubMed
    40. Li W, Zheng S, Tang C, Zhu Y, Wang X. JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. Peptides. 2007 Jun; 28(6):1252-9. PMID: 17481780.
      View in: PubMed
    41. Tang CS, Qi YF. [Advances in cardiovascular system endocrine]. Sheng Li Ke Xue Jin Zhan. 2007 Jan; 38(1):19-24. PMID: 17438948.
      View in: PubMed
    42. Ma W, Lai L, Ouyang Q, Tang C. Robustness and modular design of the Drosophila segment polarity network. Mol Syst Biol. 2006; 2:70. PMID: 17170765; PMCID: PMC1762089.
    43. Yu XM, Liu XM, Qi YF, Zhang ZG, Tang C. [The protective effects of intermedin 1-53 on oleic acid induced acute lung injury in rats]. Zhonghua Jie He He Hu Xi Za Zhi. 2006 Dec; 29(12):808-11. PMID: 17327082.
      View in: PubMed
    44. Yu XM, Liu XM, Qi YF, Zhang J, Tang C. [Alterations of intermedin and its receptor system in oleic acid-induced acute lung injury of rats]. Beijing Da Xue Xue Bao. 2006 Oct 18; 38(5):496-500. PMID: 17068622.
      View in: PubMed
    45. Shao D, Zheng W, Qiu W, Ouyang Q, Tang C. Dynamic studies of scaffold-dependent mating pathway in yeast. Biophys J. 2006 Dec 01; 91(11):3986-4001. PMID: 16980360; PMCID: PMC1635675.
    46. Jia YX, Yang JH, Pan CS, Geng B, Zhang J, Xiao Y, Zhao J, Gerns H, Yang J, Chang JK, Wen JK, Tang CS, Qi YF. Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in rats. Eur J Pharmacol. 2006 Nov 07; 549(1-3):117-23. PMID: 16987513.
      View in: PubMed
    47. Li XH, Du JB, Bu DF, Tang XY, Tang CS. Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Acta Pharmacol Sin. 2006 Aug; 27(8):971-80. PMID: 16867247.
      View in: PubMed
    48. Lou LX, Geng B, Yu F, Zhang J, Pan CS, Chen L, Qi YF, Ke Y, Wang X, Tang CS. Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats. Life Sci. 2006 Oct 04; 79(19):1856-64. PMID: 16875701.
      View in: PubMed
    49. Lu M, Yao WZ, Chen YH, Ding YL, Chang C, Tang C. [Change and clinical implication of urotensin II in plasma and induced sputum of chronic obstructive pulmonary disease]. Beijing Da Xue Xue Bao. 2006 Apr 18; 38(2):155-8. PMID: 16617357.
      View in: PubMed
    50. Wang ZJ, Shi LB, Xiong ZW, Zhang LF, Meng L, Bu DF, Tang C, Ding WH. Alteration of vascular urotensin II receptor in mice with apolipoprotein E gene knockout. Peptides. 2006 Apr; 27(4):858-63. PMID: 16325305.
      View in: PubMed
    51. Jiang H, Wang XF, Fang L, Tang C, Zhu Y, Wang X. Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells. Biochem Biophys Res Commun. 2005 Dec 02; 337(4):1084-91. PMID: 16225842.
      View in: PubMed
    52. Chen YH, Yao WZ, Geng B, Ding YL, Lu M, Zhao MW, Tang C. [Endogenous hydrogen sulfide in patients with chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi. 2005 Oct; 28(10):694-7. PMID: 16255955.
      View in: PubMed
    53. Kloster M, Tang C, Wingreen NS. Finding regulatory modules through large-scale gene-expression data analysis. Bioinformatics. 2005 Apr 01; 21(7):1172-9. PMID: 15513996.
      View in: PubMed
    54. Jiang W, Jiang HF, Cai DY, Pan CS, Qi YF, Pang YZ, Tang C. Relationship between contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock. Regul Pept. 2004 May 15; 118(3):199-208. PMID: 15003837.
      View in: PubMed
    55. Li F, Long T, Lu Y, Ouyang Q, Tang C. The yeast cell-cycle network is robustly designed. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4781-6. PMID: 15037758; PMCID: PMC387325.
    56. Li JX, Pang YZ, Tang CS, Li ZQ. Protective effect of taurine on hypochlorous acid toxicity to nuclear nucleoside triphosphatase in isolated nuclei from rat liver. World J Gastroenterol. 2004 Mar 01; 10(5):694-8. PMID: 14991940; PMCID: PMC4716911.
    57. Geng B, Yan H, Zhong GZ, Zhang CY, Chen XB, Jiang HF, Tang CS, Du JB. [Hydrogen sulfide: a novel cardiovascular functional regulatory gas factor]. Beijing Da Xue Xue Bao. 2004 Feb; 36(1):106. PMID: 14970901.
      View in: PubMed
    58. Kloster M, Tang C. Simulation and analysis of in vitro DNA evolution. Phys Rev Lett. 2004 Jan 23; 92(3):038101. PMID: 14753913.
      View in: PubMed
    59. Li JX, Li ZQ, Pang YZ, Tang CS. Phospholipase A2 inhibits nuclear nucleoside triphosphatase activity and mRNA export in isolated nuclei from rat liver. Life Sci. 2003 Jul 11; 73(8):969-80. PMID: 12818350.
      View in: PubMed
    60. Lu Y, Zou CJ, Huang DW, Tang C. Cardiovascular effects of urotensin II in different brain areas. Peptides. 2002 Sep; 23(9):1631-5. PMID: 12217424.
      View in: PubMed
    Chao's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP