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    Chao Tang, PhD

    TitleProfessor
    SchoolUCSF School of Pharmacy
    DepartmentBioengineering
    Address1700 4th Street
    San Francisco CA 94158
    Phone415-514-4414
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      University of Chicago1982 - 1982Valentine Telegdi Prize, University of Chicago
      American Physical Society1997 - 1997Fellow, the American Physical Society
      OverseaNational Science Foundation of China2002 - 2002Overseas Chinese Young Scholars Award, National Science Foundation of China
      Troisième2003 - 2003Troisième Cycle Lecture, Lausanne, Switzerland
      Chinese Ministry of Education2003 - 2003Chang Jiang Scholar Award, Chinese Ministry of Education
      Chinese University of Hong Kong2006 - 2006Croucher Lecture, Chinese University of Hong Kong
      2011 - 2011China Thousand Talent Program

      Collapse Overview 
      Collapse Overview
      We are a Systems Biology lab. We are interested in quantitative studies of biological systems, applying and developing quantitative methods and tools to address key biological questions. We believe that an interdisciplinary approach focusing on quantitative questions at a systems level will uncover new biological principles and help us to better understand complex disease and design new therapeutic strategies. The lab has both wet and dry components. Some of our current projects include: yeast cell cycle regulation, stress response, the function and topology of biological networks, modeling cancer pathways and development, systems drug design, and theoretical issues in systems biology.


      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lu WW, Jia LX, Ni XQ, Zhao L, Chang JR, Zhang JS, Hou YL, Zhu Y, Guan YF, Yu YR, Du J, Tang CS, Qi YF. Intermedin1-53 Attenuates Abdominal Aortic Aneurysm by Inhibiting Oxidative Stress. Arterioscler Thromb Vasc Biol. 2016 Nov; 36(11):2176-2190. PMID: 27634835.
        View in: PubMed
      2. Chang JR, Guo J, Wang Y, Hou YL, Lu WW, Zhang JS, Yu YR, Xu MJ, Liu XY, Wang XJ, Guan YF, Zhu Y, Du J, Tang CS, Qi YF. Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of a-Klotho. Kidney Int. 2016 Mar; 89(3):586-600. PMID: 26880455.
        View in: PubMed
      3. Lu WW, Zhao L, Zhang JS, Hou YL, Yu YR, Jia MZ, Tang CS, Qi YF. Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase. J Hypertens. 2015 Aug; 33(8):1676-87. PMID: 26136070.
        View in: PubMed
      4. Mao Y, Su J, Lei L, Meng L, Qi Y, Huo Y, Tang C. Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta. J Cardiovasc Med (Hagerstown). 2014 Jul; 15(7):572-8. PMID: 24914635.
        View in: PubMed
      5. Zhou H, Sun HJ, Chang JR, Ding L, Gao Q, Tang CS, Zhu GQ, Zhou YB. Cardiac sympathetic afferent reflex response to intermedin microinjection into paraventricular nucleus is mediated by nitric oxide and ?-amino butyric acid in hypertensive rats. Exp Biol Med (Maywood). 2014 Oct; 239(10):1352-9. PMID: 24872434.
        View in: PubMed
      6. Dai XY, Cai Y, Sun W, Ding Y, Wang W, Kong W, Tang C, Zhu Y, Xu MJ, Wang X. Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA. Cardiovasc Res. 2014 Feb 1; 101(2):297-305. PMID: 24253523.
        View in: PubMed
      7. Chang JR, Duan XH, Zhang BH, Teng X, Zhou YB, Liu Y, Yu YR, Zhu Y, Tang CS, Qi YF. Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway. Exp Biol Med (Maywood). 2013 Oct; 238(10):1136-46. PMID: 24006303.
        View in: PubMed
      8. Li L, Liu D, Bu D, Chen S, Wu J, Tang C, Du J, Jin H. Brg1-dependent epigenetic control of vascular smooth muscle cell proliferation by hydrogen sulfide. Biochim Biophys Acta. 2013 Jun; 1833(6):1347-55. PMID: 23499876.
        View in: PubMed
      9. Zheng Y, Liao F, Du JB, Tang CS, Xu GH, Geng B. [Modified methylene blue method for measurement of hydrogen sulfide level in plasma]. Sheng Li Xue Bao. 2012 Dec 25; 64(6):681-6. PMID: 23258332.
        View in: PubMed
      10. Dai XY, Cai Y, Mao DD, Qi YF, Tang C, Xu Q, Zhu Y, Xu MJ, Wang X. Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice. J Mol Cell Cardiol. 2012 Oct; 53(4):509-20. PMID: 22841663.
        View in: PubMed
      11. Zhao L, Peng DQ, Zhang J, Song JQ, Teng X, Yu YR, Tang CS, Qi YF. Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1-53 attenuating myocardial oxidative stress injury induced by ischemia/reperfusion. Peptides. 2012 Feb; 33(2):329-35. PMID: 22244813.
        View in: PubMed
      12. Wu SY, Yu YR, Cai Y, Jia LX, Wang X, Xiao CS, Tang CS, Qi YF. Endogenous aldosterone is involved in vascular calcification in rat. Exp Biol Med (Maywood). 2012 Jan; 237(1):31-7. PMID: 22185918.
        View in: PubMed
      13. Duan XH, Qu XX, Chang JR, Qi YF, Tang CS. [The endocrine function of the skeleton]. Sheng Li Ke Xue Jin Zhan. 2010 Aug; 41(4):248-55. PMID: 21416939.
        View in: PubMed
      14. Pan CS, Zhang J, Yu F, Teng X, Cao CQ, Wu W, Tang CS, Qi YF. Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice. Peptides. 2010 Jun; 31(6):1150-8. PMID: 20332006.
        View in: PubMed
      15. Pan CS, Teng X, Zhang J, Cai Y, Zhao J, Wu W, Wang X, Tang CS, Qi YF. Apelin antagonizes myocardial impairment in sepsis. J Card Fail. 2010 Jul; 16(7):609-17. PMID: 20610237.
        View in: PubMed
      16. Cai Y, Xu MJ, Teng X, Zhou YB, Chen L, Zhu Y, Wang X, Tang CS, Qi YF. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. Cardiovasc Res. 2010 Mar 1; 85(4):864-73. PMID: 19910445.
        View in: PubMed
      17. Song JQ, Teng X, Cai Y, Tang CS, Qi YF. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis. 2009 Nov; 14(11):1299-307. PMID: 19757065.
        View in: PubMed
      18. Song JQ, Teng X, Cai Y, Tang CS, Qi YF. Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis. 2009 Sep; 14(9):1061-9. PMID: 19634012.
        View in: PubMed
      19. Ma W, Trusina A, El-Samad H, Lim WA, Tang C. Defining network topologies that can achieve biochemical adaptation. Cell. 2009 Aug 21; 138(4):760-73. PMID: 19703401; PMCID: PMC3068210.
      20. Zhou YB, Jin SJ, Cai Y, Teng X, Chen L, Tang CS, Qi YF. Lanthanum acetate inhibits vascular calcification induced by vitamin D3 plus nicotine in rats. Exp Biol Med (Maywood). 2009 Aug; 234(8):908-17. PMID: 19546357.
        View in: PubMed
      21. Trusina A, Papa FR, Tang C. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. PMID: 19075238.
        View in: PubMed
      22. Li X, Du J, Jin H, Geng B, Tang C. Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Heart Vessels. 2008 Nov; 23(6):409-19. PMID: 19037589.
        View in: PubMed
      23. Yang K, Bai H, Ouyang Q, Lai L, Tang C. Finding multiple target optimal intervention in disease-related molecular network. Mol Syst Biol. 2008; 4:228. PMID: 18985027; PMCID: PMC2673713.
      24. Jin HF, Liang C, Liang JM, Tang CS, DU JB. [Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008 Aug 19; 88(32):2235-9. PMID: 19087668.
        View in: PubMed
      25. Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008 Jul 4; 321(5885):126-9. PMID: 18599789; PMCID: PMC2728800.
      26. Kloster M, Tang C. SCUMBLE: a method for systematic and accurate detection of codon usage bias by maximum likelihood estimation. Nucleic Acids Res. 2008 Jun; 36(11):3819-27. PMID: 18495752; PMCID: PMC2441815.
      27. Zhang Q, Jin H, Wang L, Chen J, Tang C, Du J. Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents. Med Sci Monit. 2008 Apr; 14(4):CR199-203. PMID: 18376348.
        View in: PubMed
      28. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9018-23. PMID: 17495027; PMCID: PMC1885620.
      29. Lau KY, Ganguli S, Tang C. Function constrains network architecture and dynamics: a case study on the yeast cell cycle Boolean network. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May; 75(5 Pt 1):051907. PMID: 17677098.
        View in: PubMed
      30. Li W, Zheng S, Tang C, Zhu Y, Wang X. JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. Peptides. 2007 Jun; 28(6):1252-9. PMID: 17481780.
        View in: PubMed
      31. Tang CS, Qi YF. [Advances in cardiovascular system endocrine]. Sheng Li Ke Xue Jin Zhan. 2007 Jan; 38(1):19-24. PMID: 17438948.
        View in: PubMed
      32. Ma W, Lai L, Ouyang Q, Tang C. Robustness and modular design of the Drosophila segment polarity network. Mol Syst Biol. 2006; 2:70. PMID: 17170765; PMCID: PMC1762089.
      33. Shao D, Zheng W, Qiu W, Ouyang Q, Tang C. Dynamic studies of scaffold-dependent mating pathway in yeast. Biophys J. 2006 Dec 1; 91(11):3986-4001. PMID: 16980360; PMCID: PMC1635675.
      34. Jia YX, Yang JH, Pan CS, Geng B, Zhang J, Xiao Y, Zhao J, Gerns H, Yang J, Chang JK, Wen JK, Tang CS, Qi YF. Intermedin1-53 protects the heart against isoproterenol-induced ischemic injury in rats. Eur J Pharmacol. 2006 Nov 7; 549(1-3):117-23. PMID: 16987513.
        View in: PubMed
      35. Li XH, Du JB, Bu DF, Tang XY, Tang CS. Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Acta Pharmacol Sin. 2006 Aug; 27(8):971-80. PMID: 16867247.
        View in: PubMed
      36. Lou LX, Geng B, Yu F, Zhang J, Pan CS, Chen L, Qi YF, Ke Y, Wang X, Tang CS. Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats. Life Sci. 2006 Oct 4; 79(19):1856-64. PMID: 16875701.
        View in: PubMed
      37. Jiang H, Wang XF, Fang L, Tang C, Zhu Y, Wang X. Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells. Biochem Biophys Res Commun. 2005 Dec 2; 337(4):1084-91. PMID: 16225842.
        View in: PubMed
      38. Kloster M, Tang C, Wingreen NS. Finding regulatory modules through large-scale gene-expression data analysis. Bioinformatics. 2005 Apr 1; 21(7):1172-9. PMID: 15513996.
        View in: PubMed
      39. Li F, Long T, Lu Y, Ouyang Q, Tang C. The yeast cell-cycle network is robustly designed. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):4781-6. PMID: 15037758; PMCID: PMC387325.
      40. Li JX, Pang YZ, Tang CS, Li ZQ. Protective effect of taurine on hypochlorous acid toxicity to nuclear nucleoside triphosphatase in isolated nuclei from rat liver. World J Gastroenterol. 2004 Mar 1; 10(5):694-8. PMID: 14991940.
        View in: PubMed
      41. Geng B, Yan H, Zhong GZ, Zhang CY, Chen XB, Jiang HF, Tang CS, Du JB. [Hydrogen sulfide: a novel cardiovascular functional regulatory gas factor]. Beijing Da Xue Xue Bao. 2004 Feb; 36(1):106. PMID: 14970901.
        View in: PubMed
      42. Kloster M, Tang C. Simulation and analysis of in vitro DNA evolution. Phys Rev Lett. 2004 Jan 23; 92(3):038101. PMID: 14753913.
        View in: PubMed
      43. Li JX, Li ZQ, Pang YZ, Tang CS. Phospholipase A2 inhibits nuclear nucleoside triphosphatase activity and mRNA export in isolated nuclei from rat liver. Life Sci. 2003 Jul 11; 73(8):969-80. PMID: 12818350.
        View in: PubMed
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