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Wendell Lim, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-502-8080
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    UCSF Center for Synthetic Immunology: Tools to Reprogram the Immune System to Combat Cancer
    NIH/NCI U54CA244438Sep 24, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Protein Recognition in Signal Transduction
    NIH/NCI R01CA220257Sep 1, 2018 - Jul 31, 2023
    Role: Principal Investigator
    Designer Tregs for restoring tolerance in patients with type 1 diabetes
    NIH/NIDDK UC4DK116264Sep 20, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Redesigning the T cell: Using Synthetic Biology to Engineer Therapeutic Cells
    NIH/NCI R01CA196277Sep 23, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Harnessing CRISPR for Targeted and Inducible Epigenomic Reprogramming
    NIH/NIDA R01DA036858Sep 30, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Exploring Design Principles of Cellular Control Circuits
    NIH/NIGMS P50GM081879Aug 1, 2010 - Jun 30, 2016
    Role: Principal Investigator
    Cellular Control: Synthetic Signaling/Motility (RMI)
    NIH/NEI PN2EY016546Sep 30, 2004 - Sep 29, 2010
    Role: Principal Investigator
    Engineering Synthetic Cell Motility Systems (RMI)
    NIH/NEI PN1EY016546Sep 30, 2004 - Jul 31, 2005
    Role: Principal Investigator
    ASSEMBLY AND TARGETING OF NEURAL RECEPTORS AND CHANNELS
    NIH/NIMH P50MH063981Aug 15, 2001 - Jul 31, 2007
    Role: Co-Investigator
    Protein Interactions Regulating Cell Motility
    NIH/NIGMS R01GM062583Feb 1, 2001 - Jan 31, 2006
    Role: Principal Investigator
    Protein Recognition in Signal Transduction
    NIH/NIGMS R01GM055040Jan 1, 1997 - Mar 31, 2007
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nat Nanotechnol. 2020 Dec 14. Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA. PMID: 33318641.
      View in: PubMed   Mentions:    Fields:    
    2. Engineering cytokines and cytokine circuits. Science. 2020 Nov 27; 370(6520):1034-1035. Li AW, Lim WA. PMID: 33243875.
      View in: PubMed   Mentions:    Fields:    
    3. Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science. 2020 Nov 27; 370(6520):1099-1104. Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. PMID: 33243890.
      View in: PubMed   Mentions:    Fields:    
    4. Engineering synthetic morphogen systems that can program multicellular patterning. Science. 2020 10 16; 370(6514):327-331. Toda S, McKeithan WL, Hakkinen TJ, Lopez P, Klein OD, Lim WA. PMID: 33060357.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies? Cell Syst. 2020 Sep 23; 11(3):212-214. Chen YY, Lim W, Levings M, Blazar B, Krenciute G, Wong W, Lehner M. PMID: 32970992.
      View in: PubMed   Mentions:    Fields:    
    6. Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies. Cell Syst. 2020 Sep 23; 11(3):215-228.e5. Dannenfelser R, Allen GM, VanderSluis B, Koegel AK, Levinson S, Stark SR, Yao V, Tadych A, Troyanskaya OG, Lim WA. PMID: 32916097.
      View in: PubMed   Mentions:    Fields:    
    7. Engineering T Cells to Treat Cancer: The Convergence of Immuno-Oncology and Synthetic Biology. Annual Review of Cancer Biology. 2020 Mar 9; 4(1):121-139. Joseph H. Choe, Jasper Z. Williams, Wendell A. Lim. .
      View in: Publisher Site   Mentions:
    8. IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi123-vi123. Payal Watchmaker, Joseph Choe, Diego Carrera, Ryan Gilbert, Wei Yu, Kira Downey, Kole Roybal, Wendell Lim, Hideho Okada. .
      View in: Publisher Site   Mentions:
    9. Simple Rules Determine Distinct Patterns of Branching Morphogenesis. Cell Syst. 2019 09 25; 9(3):221-227. Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE. PMID: 31557453.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. The Design Principles of Biochemical Timers: Circuits that Discriminate between Transient and Sustained Stimulation. Cell Syst. 2019 09 25; 9(3):297-308.e2. Gerardin J, Reddy NR, Lim WA. PMID: 31521602.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. High-throughput multicolor optogenetics in microwell plates. Nat Protoc. 2019 07; 14(7):2205-2228. Bugaj LJ, Lim WA. PMID: 31235951.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Engineering cell-cell communication networks: programming multicellular behaviors. Curr Opin Chem Biol. 2019 10; 52:31-38. Toda S, Frankel NW, Lim WA. PMID: 31150899.
      View in: PubMed   Mentions: 4     Fields:    
    13. Synthetic Development: Learning to Program Multicellular Self-Organization. Current Opinion in Systems Biology. 2019 Apr 1; 14(Nature 459 2009):41-49. Satoshi Toda, Jonathan M. Brunger, Wendell A. Lim. .
      View in: Publisher Site   Mentions:
    14. IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi134-vi134. Payal Watchmaker, Joseph Choe, Diego Carrera, Kira Downey, Maryam Shahin, Kole Roybal, Wendell Lim, Hideho Okada. .
      View in: Publisher Site   Mentions:
    15. Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science. 2018 08 31; 361(6405). Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. PMID: 30166458.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    16. Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science. 2018 07 13; 361(6398):156-162. Toda S, Blauch LR, Tang SKY, Morsut L, Lim WA. PMID: 29853554.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    17. Building a Stable Relationship: Ensuring Homeostasis among Cell Types within a Tissue. Cell. 2018 02 08; 172(4):638-640. Frankel NW, Lim WA. PMID: 29425483.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. Design of Tunable Oscillatory Dynamics in a Synthetic NF-κB Signaling Circuit. Cell Syst. 2017 11 22; 5(5):460-470.e5. Zhang ZB, Wang QY, Ke YX, Liu SY, Ju JQ, Lim WA, Tang C, Wei P. PMID: 29102361.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell. 2017 Sep 07; 67(5):757-769.e5. Wilson MZ, Ravindran PT, Lim WA, Toettcher JE. PMID: 28826673.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    20. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 04 26; 35:229-253. Roybal KT, Lim WA. PMID: 28446063.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    21. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 04 07; 7(1):737. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. PMID: 28389661.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    22. The Principles of Engineering Immune Cells to Treat Cancer. Cell. 2017 02 09; 168(4):724-740. Lim WA, June CH. PMID: 28187291.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    23. Interrogating cellular perception and decision making with optogenetic tools. J Cell Biol. 2017 Jan 02; 216(1):25-28. Bugaj LJ, O'Donoghue GP, Lim WA. PMID: 28003330.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials. Annu Rev Pathol. 2017 Jan 24; 12:305-330. Esensten JH, Bluestone JA, Lim WA. PMID: 27959633.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    25. Engineering dynamical control of cell fate switching using synthetic phospho-regulons. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):13528-13533. Gordley RM, Williams RE, Bashor CJ, Toettcher JE, Yan S, Lim WA. PMID: 27821768.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Complex transcriptional modulation with orthogonal and inducible dCas9 regulators. Nat Methods. 2016 Dec; 13(12):1043-1049. Gao Y, Xiong X, Wong S, Charles EJ, Lim WA, Qi LS. PMID: 27776111.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    27. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. PMID: 27693353.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    28. Cellular perception and misperception: Internal models for decision-making shaped by evolutionary experience. Bioessays. 2016 09; 38(9):845-9. Mitchell A, Lim W. PMID: 27461864.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. Modular engineering of cellular signaling proteins and networks. Curr Opin Struct Biol. 2016 08; 39:106-114. Gordley RM, Bugaj LJ, Lim WA. PMID: 27423114.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    30. CRISPR/Cas9 for Human Genome Engineering and Disease Research. Annu Rev Genomics Hum Genet. 2016 08 31; 17:131-54. Xiong X, Chen M, Lim WA, Zhao D, Qi LS. PMID: 27216776.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    31. Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. Elife. 2016 04 28; 5. Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R. PMID: 27130520.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    32. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. PMID: 26830878.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    33. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. PMID: 26830879.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    34. Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution. Elife. 2016 Jan 14; 5. Coyle SM, Lim WA. PMID: 26765565.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    35. Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci. Nucleic Acids Res. 2016 05 05; 44(8):e75. Chen B, Hu J, Almeida R, Liu H, Balakrishnan S, Covill-Cooke C, Lim WA, Huang B. PMID: 26740581.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    36. Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat Rev Mol Cell Biol. 2016 Jan; 17(1):5-15. Dominguez AA, Lim WA, Qi LS. PMID: 26670017.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    37. Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Science. 2015 Dec 11; 350(6266):1379-83. Mitchell A, Wei P, Lim WA. PMID: 26586187.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    38. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. PMID: 26405231.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    39. Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. Wu CY, Rupp LJ, Roybal KT, Lim WA. PMID: 26218616.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    40. Differential genetic interactions of yeast stress response MAPK pathways. Mol Syst Biol. 2015 Apr 17; 11(4):800. Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. PMID: 25888283.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    41. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell. 2015 Jan 15; 160(1-2):339-50. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. PMID: 25533786.
      View in: PubMed   Mentions: 215     Fields:    Translation:HumansAnimalsCells
    42. Specific gene repression by CRISPRi system transferred through bacterial conjugation. ACS Synth Biol. 2014 Dec 19; 3(12):929-31. Ji W, Lee D, Wong E, Dadlani P, Dinh D, Huang V, Kearns K, Teng S, Chen S, Haliburton J, Heimberg G, Heineike B, Ramasubramanian A, Stevens T, Helmke KJ, Zepeda V, Qi LS, Lim WA. PMID: 25409531.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    43. Sending mixed messages for cell population control. Cell. 2014 Aug 28; 158(5):973-975. Youk H, Lim WA. PMID: 25171399.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    44. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5896-901. Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. PMID: 24711398.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    45. Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation (609.5). The FASEB Journal. 2014 Apr 1; 28. Scott Coyle, Wendell Lim. .
      View in: Publisher Site   Mentions:
    46. Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Science. 2014 Feb 07; 343(6171):1242782. Youk H, Lim WA. PMID: 24503857.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    47. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 Dec 05; 155(6):1422-34. Toettcher JE, Weiner OD, Lim WA. PMID: 24315106.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    48. The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. PLoS One. 2013; 8(11):e78075. Jagirdar K, Yin K, Harrison M, Lim W, Muscat GE, Sturm RA, Smith AG. PMID: 24223135.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    49. Genetic sensor for strong methylating compounds. ACS Synth Biol. 2013 Oct 18; 2(10):614-24. Moser F, Horwitz A, Chen J, Lim W, Voigt CA. PMID: 24032656.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    50. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96. Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS. PMID: 24136345.
      View in: PubMed   Mentions: 209     Fields:    Translation:Cells
    51. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130008. Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. PMID: 24062580.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    52. Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16015-20. Puchner EM, Walter JM, Kasper R, Huang B, Lim WA. PMID: 24043832.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    53. Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation. Cell. 2013 Aug 15; 154(4):875-87. Coyle SM, Flores J, Lim WA. PMID: 23953117.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    54. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. PMID: 23849981.
      View in: PubMed   Mentions: 849     Fields:    Translation:HumansAnimalsCells
    55. Improved blue, green, and red fluorescent protein tagging vectors for S. cerevisiae. PLoS One. 2013; 8(7):e67902. Lee S, Lim WA, Thorn KS. PMID: 23844123.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    56. Signalling change: signal transduction through the decades. Nat Rev Mol Cell Biol. 2013 Jun; 14(6):393-8. Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massagué J, Pawson T. PMID: 23636498.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    57. Cell-based therapeutics: the next pillar of medicine. Sci Transl Med. 2013 Apr 03; 5(179):179ps7. Fischbach MA, Bluestone JA, Lim WA. PMID: 23552369.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    58. Bridging cross-cultural gaps in scientific exchange through innovative team challenge workshops. Quant Biol. 2013 Mar; 1(1):3-8. Lee CM, Gong S, Tang C, Lim WA. PMID: 25339992.
      View in: PubMed   Mentions:
    59. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. PMID: 23452860.
      View in: PubMed   Mentions: 1020     Fields:    Translation:Cells
    60. Design principles of regulatory networks: searching for the molecular algorithms of the cell. Mol Cell. 2013 Jan 24; 49(2):202-12. Lim WA, Lee CM, Tang C. PMID: 23352241.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    61. Probing Molecular Number Variability in Intracellular Structures using Photoswitchable Fluorescent Proteins. Biophysical Journal. 2013 Jan 1; 104(2):201a. Elias M. Puchner, Jessica M. Walter, Robert Kasper, Bo Huang, Wendell A. Lim. .
      View in: Publisher Site   Mentions:
    62. Cell biology 2.0. Trends Cell Biol. 2012 Dec; 22(12):611-2. Lim WA, Alvania R, Marshall WF. PMID: 23142093.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    63. Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell. 2012 Oct 12; 151(2):320-32. Chau AH, Walter JM, Gerardin J, Tang C, Lim WA. PMID: 23039994.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    64. Wendell Lim: exploring the path not chosen. Interview by Caitlin Sedwick. J Cell Biol. 2012 Sep 17; 198(6):956-7. Lim W. PMID: 22986491.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    65. The first World Cell Race. Curr Biol. 2012 Sep 11; 22(17):R673-5. Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Lim JC, Sim CP, Chu YS, Jiménez-Dalmaroni A, Joanny JF, Thiery JP, Erfle H, Parsons M, Mitchison TJ, Lim WA, Lennon-Duménil AM, Piel M, Théry M. PMID: 22974990.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    66. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 2012 Aug 16; 488(7411):384-8. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. PMID: 22820255.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    67. Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science. 2012 Sep 07; 337(6099):1218-22. Zalatan JG, Coyle SM, Rajan S, Sidhu SS, Lim WA. PMID: 22878499.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    68. Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20; 150(2):413-25. Beltrao P, Albanèse V, Kenner LR, Swaney DL, Burlingame A, Villén J, Lim WA, Fraser JS, Frydman J, Krogan NJ. PMID: 22817900.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    69. SYNZIP protein interaction toolbox: in vitro and in vivo specifications of heterospecific coiled-coil interaction domains. ACS Synth Biol. 2012 Apr 20; 1(4):118-29. Thompson KE, Bashor CJ, Lim WA, Keating AE. PMID: 22558529.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    70. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5277-82. Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. PMID: 22403064.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    71. A Light-Based Feedback Control System for Generating User-Defined Intracelullar Signaling Dynamics. Biophysical Journal. 2012 Jan 1; 102(3):41a. Jared Toettcher, Delquin Gong, Wendell A. Lim, Orion Weiner. .
      View in: Publisher Site   Mentions:
    72. Light-based feedback for controlling intracellular signaling dynamics. Nat Methods. 2011 Sep 11; 8(10):837-9. Toettcher JE, Gong D, Lim WA, Weiner OD. PMID: 21909100.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    73. Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9809-14. Won AP, Garbarino JE, Lim WA. PMID: 21628578.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    74. Scaffold proteins: hubs for controlling the flow of cellular information. Science. 2011 May 06; 332(6030):680-6. Good MC, Zalatan JG, Lim WA. PMID: 21551057.
      View in: PubMed   Mentions: 282     Fields:    Translation:AnimalsCells
    75. Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells. Pigment Cell Melanoma Res. 2011 Jun; 24(3):551-63. Smith AG, Lim W, Pearen M, Muscat GE, Sturm RA. PMID: 21362156.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    76. Light control of plasma membrane recruitment using the Phy-PIF system. Methods Enzymol. 2011; 497:409-23. Toettcher JE, Gong D, Lim WA, Weiner OD. PMID: 21601096.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    77. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods. 2011 Jan; 8(1):35-8. Toettcher JE, Voigt CA, Weiner OD, Lim WA. PMID: 21191370.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    78. Build life to understand it. Nature. 2010 Dec 16; 468(7326):889-90. Elowitz M, Lim WA. PMID: 21164460.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    79. Phosphotyrosine signaling: evolving a new cellular communication system. Cell. 2010 Sep 03; 142(5):661-7. Lim WA, Pawson T. PMID: 20813250.
      View in: PubMed   Mentions: 130     Fields:    Translation:AnimalsCells
    80. The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One. 2010 Jun 24; 5(6):e11291. Ahmad KF, Lim WA. PMID: 20585582.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    81. Designing customized cell signalling circuits. Nat Rev Mol Cell Biol. 2010 Jun; 11(6):393-403. Lim WA. PMID: 20485291.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    82. Rapid diversification of cell signaling phenotypes by modular domain recombination. Science. 2010 Apr 16; 328(5976):368-72. Peisajovich SG, Garbarino JE, Wei P, Lim WA. PMID: 20395511.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    83. The Design Logic of Cell Signaling Systems. The FASEB Journal. 2010 Apr 1; 24:410.2-410.2. Wendell A Lim. .
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    84. Defining network topologies that can achieve biochemical adaptation. The FASEB Journal. 2010 Apr 1; 24:190.1-190.1. Chao Tang, Wenzhe Ma, Ala Trusina, Hana El-Samad, Wendell Lim. .
      View in: Publisher Site   Mentions:
    85. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal. 2010 Feb 16; 3(109):ra12. Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M, Turk BE. PMID: 20159853.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    86. Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems. Annu Rev Biophys. 2010; 39:515-37. Bashor CJ, Horwitz AA, Peisajovich SG, Lim WA. PMID: 20192780.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    87. Reengineering the signaling properties of a Src family kinase. Biochemistry. 2009 Nov 24; 48(46):10956-62. Yadav SS, Yeh BJ, Craddock BP, Lim WA, Miller WT. PMID: 19827767.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    88. A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. Mol Cell. 2009 Nov 13; 36(3):525-35. Rivera GM, Vasilescu D, Papayannopoulos V, Lim WA, Mayer BJ. PMID: 19917259.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    89. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15; 461(7266):997-1001. Levskaya A, Weiner OD, Lim WA, Voigt CA. PMID: 19749742.
      View in: PubMed   Mentions: 331     Fields:    Translation:AnimalsCells
    90. Defining network topologies that can achieve biochemical adaptation. Cell. 2009 Aug 21; 138(4):760-73. Ma W, Trusina A, El-Samad H, Lim WA, Tang C. PMID: 19703401.
      View in: PubMed   Mentions: 267     Fields:    Translation:Cells
    91. Scaffolds: interaction platforms for cellular signalling circuits. Trends Cell Biol. 2009 Aug; 19(8):364-74. Zeke A, Lukács M, Lim WA, Reményi A. PMID: 19651513.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    92. Positive selection of tyrosine loss in metazoan evolution. Science. 2009 Sep 25; 325(5948):1686-8. Tan CS, Pasculescu A, Lim WA, Pawson T, Bader GD, Linding R. PMID: 19589966.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    93. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol. 2009 Jun 16; 7(6):e1000134. Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim WA, Shokat KM, Burlingame AL, Krogan NJ. PMID: 19547744.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    94. The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell. 2009 Mar 20; 136(6):1085-97. Good M, Tang G, Singleton J, Reményi A, Lim WA. PMID: 19303851.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    95. Frederic M Richards 1925-2009. Nat Struct Mol Biol. 2009 Mar; 16(3):230-2. Lim WA. PMID: 19259121.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    96. The Modular Logic of Cell Signaling Systems. Biophysical Journal. 2009 Feb 1; 96(3):3a. Wendell Lim. .
      View in: Publisher Site   Mentions:
    97. The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature. 2008 Aug 21; 454(7207):1005-8. Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim WA. PMID: 18650806.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    98. Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9680-4. Pincus D, Letunic I, Bork P, Lim WA. PMID: 18599463.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    99. Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science. 2008 Mar 14; 319(5869):1539-43. Bashor CJ, Helman NC, Yan S, Lim WA. PMID: 18339942.
      View in: PubMed   Mentions: 150     Fields:    Translation:AnimalsCells
    100. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature. 2008 Feb 14; 451(7180):783-8. King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, Zuzow R, Dirks W, Good M, Goodstein D, Lemons D, Li W, Lyons JB, Morris A, Nichols S, Richter DJ, Salamov A, Sequencing JG, Bork P, Lim WA, Manning G, Miller WT, McGinnis W, Shapiro H, Tjian R, Grigoriev IV, Rokhsar D. PMID: 18273011.
      View in: PubMed   Mentions: 394     Fields:    Translation:HumansAnimalsCells
    101. A microfluidic system for dynamic yeast cell imaging. Biotechniques. 2008 Jan; 44(1):91-5. Lee PJ, Helman NC, Lim WA, Hung PJ. PMID: 18254385.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    102. Synthetic biology: lessons from the history of synthetic organic chemistry. Nat Chem Biol. 2007 Sep; 3(9):521-5. Yeh BJ, Lim WA. PMID: 17710092.
      View in: PubMed   Mentions: 19     Fields:    
    103. Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature. 2007 May 31; 447(7144):596-600. Yeh BJ, Rutigliano RJ, Deb A, Bar-Sagi D, Lim WA. PMID: 17515921.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    104. Engineering synthetic signaling proteins with ultrasensitive input/output control. Nat Biotechnol. 2007 Jun; 25(6):660-2. Dueber JE, Mirsky EA, Lim WA. PMID: 17515908.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    105. Engineering modular protein interaction switches by sequence overlap. J Am Chem Soc. 2007 Apr 18; 129(15):4606-11. Sallee NA, Yeh BJ, Lim WA. PMID: 17381089.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    106. Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J Biol Chem. 2007 Mar 16; 282(11):8446-53. Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF. PMID: 17229736.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    107. Beta strand peptidomimetics as potent PDZ domain ligands. Chem Biol. 2006 Dec; 13(12):1247-51. Hammond MC, Harris BZ, Lim WA, Bartlett PA. PMID: 17185220.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    108. Docking interactions in protein kinase and phosphatase networks. Curr Opin Struct Biol. 2006 Dec; 16(6):676-85. Reményi A, Good MC, Lim WA. PMID: 17079133.
      View in: PubMed   Mentions: 76     Fields:    Translation:Cells
    109. The Modular Logic of Cell Signaling Systems. The FASEB Journal. 2006 Mar 1; 20(5):a1473-a1473. Wendell A Lim. .
      View in: Publisher Site   Mentions:
    110. The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science. 2006 Feb 10; 311(5762):822-6. Bhattacharyya RP, Reményi A, Good MC, Bashor CJ, Falick AM, Lim WA. PMID: 16424299.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    111. Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu Rev Biochem. 2006; 75:655-80. Bhattacharyya RP, Reményi A, Yeh BJ, Lim WA. PMID: 16756506.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    112. The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol Cell. 2005 Dec 22; 20(6):951-62. Reményi A, Good MC, Bhattacharyya RP, Lim WA. PMID: 16364919.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    113. A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. J Biol Chem. 2005 Nov 18; 280(46):38528-36. Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim WA. PMID: 16147993.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    114. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell. 2005 Jan 21; 17(2):181-91. Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA. PMID: 15664188.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    115. Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry. Curr Opin Struct Biol. 2004 Dec; 14(6):690-9. Dueber JE, Yeh BJ, Bhattacharyya RP, Lim WA. PMID: 15582393.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    116. Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway. Mol Cell. 2004 Jun 18; 14(6):825-32. Zarrinpar A, Bhattacharyya RP, Nittler MP, Lim WA. PMID: 15200959.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    117. Optimization of specificity in a cellular protein interaction network by negative selection. Nature. 2003 Dec 11; 426(6967):676-80. Zarrinpar A, Park SH, Lim WA. PMID: 14668868.
      View in: PubMed   Mentions: 104     Fields:    Translation:Cells
    118. Reprogramming control of an allosteric signaling switch through modular recombination. Science. 2003 Sep 26; 301(5641):1904-8. Dueber JE, Yeh BJ, Chak K, Lim WA. PMID: 14512628.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    119. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Nat Genet. 2003 May; 34(1):91-6. Carlton VE, Harris BZ, Puffenberger EG, Batta AK, Knisely AS, Robinson DL, Strauss KA, Shneider BL, Lim WA, Salen G, Morton DH, Bull LN. PMID: 12704386.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    120. The structure and function of proline recognition domains. Sci STKE. 2003 Apr 22; 2003(179):RE8. Zarrinpar A, Bhattacharyya RP, Lim WA. PMID: 12709533.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    121. Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry. 2003 Mar 18; 42(10):2797-805. Harris BZ, Lau FW, Fujii N, Guy RK, Lim WA. PMID: 12627945.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    122. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science. 2003 Feb 14; 299(5609):1061-4. Park SH, Zarrinpar A, Lim WA. PMID: 12511654.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    123. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell. 2002 Nov 15; 111(4):565-76. Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA. PMID: 12437929.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    124. Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function. Nat Neurosci. 2002 Nov; 5(11):1147-54. Yu TW, Hao JC, Lim W, Tessier-Lavigne M, Bargmann CI. PMID: 12379860.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    125. Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. J Biol Chem. 2002 Sep 20; 277(38):34902-8. Harris BZ, Venkatasubrahmanyam S, Lim WA. PMID: 12110687.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    126. How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2. Curr Opin Cell Biol. 2002 Apr; 14(2):149-54. Prehoda KE, Lim WA. PMID: 11891112.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    127. The modular logic of signaling proteins: building allosteric switches from simple binding domains. Curr Opin Struct Biol. 2002 Feb; 12(1):61-8. Lim WA. PMID: 11839491.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    128. From folding towards function. Current Opinion in Structural Biology. 2002 Feb 1; 12(1):11-13. David Baker, Wendell A Lim. .
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    129. Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Mol Cell. 2001 Dec; 8(6):1291-301. McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE. PMID: 11779504.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    130. Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci. 2001 Sep; 114(Pt 18):3219-31. Harris BZ, Lim WA. PMID: 11591811.
      View in: PubMed   Mentions: 226     Fields:    Translation:HumansAnimalsCells
    131. The double life of PX domains. Nat Struct Biol. 2001 Jul; 8(7):570-2. Prehoda KE, Lim WA. PMID: 11427879.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    132. Energetic determinants of internal motif recognition by PDZ domains. Biochemistry. 2001 May 22; 40(20):5921-30. Harris BZ, Hillier BJ, Lim WA. PMID: 11352727.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    133. An analysis of the interactions between the Sem-5 SH3 domain and its ligands using molecular dynamics, free energy calculations, and sequence analysis. J Am Chem Soc. 2001 May 02; 123(17):3986-94. Wang W, Lim WA, Jakalian A, Wang J, Wang J, Luo R, Bayly CI, Kollman PA. PMID: 11457149.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    134. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science. 2000 Oct 27; 290(5492):801-6. Prehoda KE, Scott JA, Mullins RD, Lim WA. PMID: 11052943.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansCells
    135. Converging on proline: the mechanism of WW domain peptide recognition. Nat Struct Biol. 2000 Aug; 7(8):611-3. Zarrinpar A, Lim WA. PMID: 10932238.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    136. Improving SH3 domain ligand selectivity using a non-natural scaffold. Chem Biol. 2000 Jul; 7(7):463-73. Nguyen JT, Porter M, Amoui M, Miller WT, Zuckermann RN, Lim WA. PMID: 10903934.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    137. PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J Biol Chem. 1999 Sep 24; 274(39):27467-73. Christopherson KS, Hillier BJ, Lim WA, Bredt DS. PMID: 10488080.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    138. Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly. Cell. 1999 May 14; 97(4):471-80. Prehoda KE, Lee DJ, Lim WA. PMID: 10338211.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    139. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science. 1999 Apr 30; 284(5415):812-5. Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. PMID: 10221915.
      View in: PubMed   Mentions: 148     Fields:    Translation:Cells
    140. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science. 1998 Dec 11; 282(5396):2088-92. Nguyen JT, Turck CW, Cohen FE, Zuckermann RN, Lim WA. PMID: 9851931.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    141. How Src exercises self-restraint. Nat Struct Biol. 1997 Apr; 4(4):256-60. Nguyen JT, Lim WA. PMID: 9095189.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    142. Reading between the lines: SH3 recognition of an intact protein. Structure. 1996 Jun 15; 4(6):657-9. Lim WA. PMID: 8805558.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    143. Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature. 1994 Nov 24; 372(6504):375-9. Lim WA, Richards FM, Fox RO. PMID: 7802869.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    144. Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem-5. Protein Sci. 1994 Aug; 3(8):1261-6. Lim WA, Fox RO, Richards FM. PMID: 7987221.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    145. Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition. Nat Struct Biol. 1994 Apr; 1(4):221-5. Lim WA, Richards FM. PMID: 7656049.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    146. The crystal structure of a mutant protein with altered but improved hydrophobic core packing. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):423-7. Lim WA, Hodel A, Sauer RT, Richards FM. PMID: 8278404.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    147. An analysis of packing in the protein folding problem. Q Rev Biophys. 1993 Nov; 26(4):423-98. Richards FM, Lim WA. PMID: 8058892.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    148. Structural and energetic consequences of disruptive mutations in a protein core. Biochemistry. 1992 May 05; 31(17):4324-33. Lim WA, Farruggio DC, Sauer RT. PMID: 1567879.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    149. The role of internal packing interactions in determining the structure and stability of a protein. J Mol Biol. 1991 May 20; 219(2):359-76. Lim WA, Sauer RT. PMID: 2038061.
      View in: PubMed   Mentions: 68     Fields:    Translation:Cells
    150. Analysis of DNA-protein interactions by affinity coelectrophoresis. Methods Enzymol. 1991; 208:196-210. Lim WA, Sauer RT, Lander AD. PMID: 1838134.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    151. Random mutagenesis of protein sequences using oligonucleotide cassettes. Methods Enzymol. 1991; 208:564-86. Reidhaar-Olson JF, Bowie JU, Breyer RM, Hu JC, Knight KL, Lim WA, Mossing MC, Parsell DA, Shoemaker KR, Sauer RT. PMID: 1779849.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    152. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science. 1990 Mar 16; 247(4948):1306-10. Bowie JU, Reidhaar-Olson JF, Lim WA, Sauer RT. PMID: 2315699.
      View in: PubMed   Mentions: 118     Fields:    Translation:Cells
    153. Alternative packing arrangements in the hydrophobic core of lambda repressor. Nature. 1989 May 04; 339(6219):31-6. Lim WA, Sauer RT. PMID: 2524006.
      View in: PubMed   Mentions: 86     Fields:    Translation:Cells
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