Loading...

Wendell Lim, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentCellular Molecular Pharmacology
Address600 16th St
San Francisco CA 94158
Phone415-502-8080
vCardDownload vCard
    Other Positions
    TitleHoward Hughes Investigator


    Collapse Research 
    Collapse Research Activities and Funding
    Designer Tregs for restoring tolerance in patients with type 1 diabetes
    NIH/NIDDK UC4DK116264Sep 20, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Redesigning the T cell: Using Synthetic Biology to Engineer Therapeutic Cells
    NIH/NCI R01CA196277Sep 23, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Harnessing CRISPR for Targeted and Inducible Epigenomic Reprogramming
    NIH/NIDA R01DA036858Sep 30, 2013 - May 31, 2018
    Role: Co-Principal Investigator
    Exploring Design Principles of Cellular Control Circuits
    NIH/NIGMS P50GM081879Aug 1, 2010 - Jul 31, 2018
    Role: Principal Investigator
    Cellular Control: Synthetic Signaling/Motility (RMI)
    NIH/NEI PN2EY016546Sep 30, 2004 - Jul 31, 2015
    Role: Principal Investigator
    Engineering Synthetic Cell Motility Systems (RMI)
    NIH/NEI PN1EY016546Sep 30, 2004 - Jul 31, 2005
    Role: Principal Investigator
    ASSEMBLY AND TARGETING OF NEURAL RECEPTORS AND CHANNELS
    NIH/NIMH P50MH063981Aug 15, 2001 - Jul 31, 2007
    Role: Co-Investigator
    Protein Interactions Regulating Cell Motility
    NIH/NIGMS R01GM062583Feb 1, 2001 - Apr 30, 2012
    Role: Principal Investigator
    Protein Recognition in Signal Transduction
    NIH/NIGMS R01GM055040Jan 1, 1997 - Jul 31, 2016
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Frankel NW, Lim W. Building a Stable Relationship: Ensuring Homeostasis among Cell Types within a Tissue. Cell. 2018 Feb 08; 172(4):638-640. PMID: 29425483.
      View in: PubMed
    2. Zhang ZB, Wang QY, Ke YX, Liu SY, Ju JQ, Lim W, Tang C, Wei P. Design of Tunable Oscillatory Dynamics in a Synthetic NF-?B Signaling Circuit. Cell Syst. 2017 Nov 22; 5(5):460-470.e5. PMID: 29102361.
      View in: PubMed
    3. Wilson MZ, Ravindran PT, Lim W, Toettcher JE. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell. 2017 Sep 07; 67(5):757-769.e5. PMID: 28826673.
      View in: PubMed
    4. Roybal KT, Lim W. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annu Rev Immunol. 2017 Apr 26; 35:229-253. PMID: 28446063.
      View in: PubMed
    5. Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim W, Marson A. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Sci Rep. 2017 04 07; 7(1):737. PMID: 28389661.
      View in: PubMed
    6. Lim W, June CH. The Principles of Engineering Immune Cells to Treat Cancer. Cell. 2017 Feb 09; 168(4):724-740. PMID: 28187291.
      View in: PubMed
    7. Bugaj LJ, O'Donoghue GP, Lim W. Interrogating cellular perception and decision making with optogenetic tools. J Cell Biol. 2017 Jan 02; 216(1):25-28. PMID: 28003330.
      View in: PubMed
    8. Esensten JH, Bluestone JA, Lim W. Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials. Annu Rev Pathol. 2017 Jan 24; 12:305-330. PMID: 27959633.
      View in: PubMed
    9. Gordley RM, Williams RE, Bashor CJ, Toettcher JE, Yan S, Lim W. Engineering dynamical control of cell fate switching using synthetic phospho-regulons. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):13528-13533. PMID: 27821768.
      View in: PubMed
    10. Gao Y, Xiong X, Wong S, Charles EJ, Lim W, Qi LS. Complex transcriptional modulation with orthogonal and inducible dCas9 regulators. Nat Methods. 2016 Dec; 13(12):1043-1049. PMID: 27776111.
      View in: PubMed
    11. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim W. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. PMID: 27693353.
      View in: PubMed
    12. Mitchell A, Lim W. Cellular perception and misperception: Internal models for decision-making shaped by evolutionary experience. Bioessays. 2016 09; 38(9):845-9. PMID: 27461864.
      View in: PubMed
    13. Gordley RM, Bugaj LJ, Lim W. Modular engineering of cellular signaling proteins and networks. Curr Opin Struct Biol. 2016 08; 39:106-114. PMID: 27423114.
      View in: PubMed
    14. Xiong X, Chen M, Lim W, Zhao D, Qi LS. CRISPR/Cas9 for Human Genome Engineering and Disease Research. Annu Rev Genomics Hum Genet. 2016 Aug 31; 17:131-54. PMID: 27216776.
      View in: PubMed
    15. Isaac RS, Jiang F, Doudna JA, Lim W, Narlikar GJ, Almeida R. Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. Elife. 2016 04 28; 5. PMID: 27130520; PMCID: PMC4880442.
      View in: PubMed, PubMed Central
    16. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim W. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. PMID: 26830878; PMCID: PMC4752866 [Available on 02/11/17].
      View in: PubMed, PubMed Central
    17. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim W. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. PMID: 26830879; PMCID: PMC4752902 [Available on 02/11/17].
      View in: PubMed, PubMed Central
    18. Coyle SM, Lim W. Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution. Elife. 2016 Jan 14; 5. PMID: 26765565; PMCID: PMC4775219.
      View in: PubMed, PubMed Central
    19. Chen B, Hu J, Almeida R, Liu H, Balakrishnan S, Covill-Cooke C, Lim W, Huang B. Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci. Nucleic Acids Res. 2016 05 05; 44(8):e75. PMID: 26740581; PMCID: PMC4856973.
      View in: PubMed, PubMed Central
    20. Dominguez AA, Lim W, Qi LS. Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat Rev Mol Cell Biol. 2016 Jan; 17(1):5-15. PMID: 26670017; PMCID: PMC4922510.
      View in: PubMed, PubMed Central
    21. Mitchell A, Wei P, Lim W. Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network. Science. 2015 Dec 11; 350(6266):1379-83. PMID: 26586187; PMCID: PMC4721531.
      View in: PubMed, PubMed Central
    22. Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim W. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science. 2015 Oct 16; 350(6258):aab4077. PMID: 26405231; PMCID: PMC4721629.
      View in: PubMed, PubMed Central
    23. Wu CY, Rupp LJ, Roybal KT, Lim W. Synthetic biology approaches to engineer T cells. Curr Opin Immunol. 2015 Aug; 35:123-30. PMID: 26218616; PMCID: PMC4553068.
      View in: PubMed, PubMed Central
    24. Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. Differential genetic interactions of yeast stress response MAPK pathways. Mol Syst Biol. 2015 Apr 17; 11(4):800. PMID: 25888283; PMCID: PMC4422557.
      View in: PubMed, PubMed Central
    25. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim W. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell. 2015 Jan 15; 160(1-2):339-50. PMID: 25533786; PMCID: PMC4297522.
      View in: PubMed, PubMed Central
    26. Ji W, Lee D, Wong E, Dadlani P, Dinh D, Huang V, Kearns K, Teng S, Chen S, Haliburton J, Heimberg G, Heineike B, Ramasubramanian A, Stevens T, Helmke KJ, Zepeda V, Qi LS, Lim W. Specific gene repression by CRISPRi system transferred through bacterial conjugation. ACS Synth Biol. 2014 Dec 19; 3(12):929-31. PMID: 25409531; PMCID: PMC4277763.
      View in: PubMed, PubMed Central
    27. Youk H, Lim W. Sending mixed messages for cell population control. Cell. 2014 Aug 28; 158(5):973-975. PMID: 25171399; PMCID: PMC4351990.
      View in: PubMed, PubMed Central
    28. Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim W. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5896-901. PMID: 24711398; PMCID: PMC4000811.
      View in: PubMed, PubMed Central
    29. Youk H, Lim W. Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Science. 2014 Feb 07; 343(6171):1242782. PMID: 24503857; PMCID: PMC4145839.
      View in: PubMed, PubMed Central
    30. Toettcher JE, Weiner OD, Lim W. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 Dec 05; 155(6):1422-34. PMID: 24315106; PMCID: PMC3925772.
      View in: PubMed, PubMed Central
    31. Jagirdar K, Yin K, Harrison M, Lim W, Muscat GE, Sturm RA, Smith AG. The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. PLoS One. 2013; 8(11):e78075. PMID: 24223135; PMCID: PMC3819332.
      View in: PubMed, PubMed Central
    32. Moser F, Horwitz A, Chen J, Lim W, Voigt CA. Genetic sensor for strong methylating compounds. ACS Synth Biol. 2013 Oct 18; 2(10):614-24. PMID: 24032656; PMCID: PMC3859139.
      View in: PubMed, PubMed Central
    33. Larson MH, Gilbert LA, Wang X, Lim W, Weissman JS, Qi LS. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96. PMID: 24136345; PMCID: PMC3922765.
      View in: PubMed, PubMed Central
    34. Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim W, Weiner OD. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130008. PMID: 24062580; PMCID: PMC3785960.
      View in: PubMed, PubMed Central
    35. Puchner EM, Walter JM, Kasper R, Huang B, Lim W. Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):16015-20. PMID: 24043832; PMCID: PMC3791776.
      View in: PubMed, PubMed Central
    36. Coyle SM, Flores J, Lim W. Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation. Cell. 2013 Aug 15; 154(4):875-87. PMID: 23953117; PMCID: PMC3787944.
      View in: PubMed, PubMed Central
    37. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim W, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. PMID: 23849981; PMCID: PMC3770145.
      View in: PubMed, PubMed Central
    38. Lee S, Lim W, Thorn KS. Improved blue, green, and red fluorescent protein tagging vectors for S. cerevisiae. PLoS One. 2013; 8(7):e67902. PMID: 23844123; PMCID: PMC3699464.
      View in: PubMed, PubMed Central
    39. Hynes NE, Ingham PW, Lim W, Marshall CJ, Massagué J, Pawson T. Signalling change: signal transduction through the decades. Nat Rev Mol Cell Biol. 2013 Jun; 14(6):393-8. PMID: 23636498.
      View in: PubMed
    40. Fischbach MA, Bluestone JA, Lim W. Cell-based therapeutics: the next pillar of medicine. Sci Transl Med. 2013 Apr 03; 5(179):179ps7. PMID: 23552369; PMCID: PMC3772767.
      View in: PubMed, PubMed Central
    41. Lee CM, Gong S, Tang C, Lim W. Bridging cross-cultural gaps in scientific exchange through innovative team challenge workshops. Quant Biol. 2013 Mar; 1(1):3-8. PMID: 25339992.
      View in: PubMed
    42. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim W. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. PMID: 23452860; PMCID: PMC3664290.
      View in: PubMed, PubMed Central
    43. Lim W, Lee CM, Tang C. Design principles of regulatory networks: searching for the molecular algorithms of the cell. Mol Cell. 2013 Jan 24; 49(2):202-12. PMID: 23352241; PMCID: PMC3664230.
      View in: PubMed, PubMed Central
    44. Lim W, Alvania R, Marshall WF. Cell biology 2.0. Trends Cell Biol. 2012 Dec; 22(12):611-2. PMID: 23142093.
      View in: PubMed
    45. Chau AH, Walter JM, Gerardin J, Tang C, Lim W. Designing synthetic regulatory networks capable of self-organizing cell polarization. Cell. 2012 Oct 12; 151(2):320-32. PMID: 23039994; PMCID: PMC3498761.
      View in: PubMed, PubMed Central
    46. Lim W. Wendell Lim: exploring the path not chosen. Interview by Caitlin Sedwick. J Cell Biol. 2012 Sep 17; 198(6):956-7. PMID: 22986491; PMCID: PMC3444780.
      View in: PubMed, PubMed Central
    47. Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Lim W, Sim CP, Chu YS. The first World Cell Race. Curr Biol. 2012 Sep 11; 22(17):R673-5. PMID: 22974990; PMCID: PMC3770281.
      View in: PubMed, PubMed Central
    48. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim W. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 2012 Aug 16; 488(7411):384-8. PMID: 22820255; PMCID: PMC3422413.
      View in: PubMed, PubMed Central
    49. Zalatan JG, Coyle SM, Rajan S, Sidhu SS, Lim W. Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation. Science. 2012 Sep 07; 337(6099):1218-22. PMID: 22878499; PMCID: PMC3631425.
      View in: PubMed, PubMed Central
    50. Beltrao P, Albanèse V, Kenner LR, Swaney DL, Burlingame A, Villén J, Lim W, Fraser JS, Frydman J, Krogan NJ. Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20; 150(2):413-25. PMID: 22817900; PMCID: PMC3404735.
      View in: PubMed, PubMed Central
    51. Thompson KE, Bashor CJ, Lim W, Keating AE. SYNZIP protein interaction toolbox: in vitro and in vivo specifications of heterospecific coiled-coil interaction domains. ACS Synth Biol. 2012 Apr 20; 1(4):118-29. PMID: 22558529.
      View in: PubMed
    52. Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim W, Kortemme T. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5277-82. PMID: 22403064; PMCID: PMC3325720.
      View in: PubMed, PubMed Central
    53. Toettcher JE, Gong D, Lim W, Weiner OD. Light-based feedback for controlling intracellular signaling dynamics. Nat Methods. 2011 Sep 11; 8(10):837-9. PMID: 21909100; PMCID: PMC3184382.
      View in: PubMed, PubMed Central
    54. Won AP, Garbarino JE, Lim W. Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9809-14. PMID: 21628578; PMCID: PMC3116413.
      View in: PubMed, PubMed Central
    55. Good MC, Zalatan JG, Lim W. Scaffold proteins: hubs for controlling the flow of cellular information. Science. 2011 May 06; 332(6030):680-6. PMID: 21551057; PMCID: PMC3117218.
      View in: PubMed, PubMed Central
    56. Smith AG, Lim W, Pearen M, Muscat GE, Sturm RA. Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells. Pigment Cell Melanoma Res. 2011 Jun; 24(3):551-63. PMID: 21362156.
      View in: PubMed
    57. Toettcher JE, Gong D, Lim W, Weiner OD. Light control of plasma membrane recruitment using the Phy-PIF system. Methods Enzymol. 2011; 497:409-23. PMID: 21601096; PMCID: PMC3121701.
      View in: PubMed, PubMed Central
    58. Toettcher JE, Voigt CA, Weiner OD, Lim W. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods. 2011 Jan; 8(1):35-8. PMID: 21191370; PMCID: PMC3024327.
      View in: PubMed, PubMed Central
    59. Elowitz M, Lim W. Build life to understand it. Nature. 2010 Dec 16; 468(7326):889-90. PMID: 21164460; PMCID: PMC3068207.
      View in: PubMed, PubMed Central
    60. Lim W, Pawson T. Phosphotyrosine signaling: evolving a new cellular communication system. Cell. 2010 Sep 03; 142(5):661-7. PMID: 20813250; PMCID: PMC2950826.
      View in: PubMed, PubMed Central
    61. Ahmad KF, Lim W. The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One. 2010 Jun 24; 5(6):e11291. PMID: 20585582.
      View in: PubMed
    62. Lim W. Designing customized cell signalling circuits. Nat Rev Mol Cell Biol. 2010 Jun; 11(6):393-403. PMID: 20485291; PMCID: PMC2975372.
      View in: PubMed, PubMed Central
    63. Peisajovich SG, Garbarino JE, Wei P, Lim W. Rapid diversification of cell signaling phenotypes by modular domain recombination. Science. 2010 Apr 16; 328(5976):368-72. PMID: 20395511; PMCID: PMC2975375.
      View in: PubMed, PubMed Central
    64. Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim W, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M, Turk BE. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal. 2010 Feb 16; 3(109):ra12. PMID: 20159853; PMCID: PMC2846625.
      View in: PubMed, PubMed Central
    65. Bashor CJ, Horwitz AA, Peisajovich SG, Lim W. Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems. Annu Rev Biophys. 2010; 39:515-37. PMID: 20192780; PMCID: PMC2965450.
      View in: PubMed, PubMed Central
    66. Yadav SS, Yeh BJ, Craddock BP, Lim W, Miller WT. Reengineering the signaling properties of a Src family kinase. Biochemistry. 2009 Nov 24; 48(46):10956-62. PMID: 19827767; PMCID: PMC2847435.
      View in: PubMed, PubMed Central
    67. Rivera GM, Vasilescu D, Papayannopoulos V, Lim W, Mayer BJ. A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells. Mol Cell. 2009 Nov 13; 36(3):525-35. PMID: 19917259; PMCID: PMC2793683.
      View in: PubMed, PubMed Central
    68. Levskaya A, Weiner OD, Lim W, Voigt CA. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15; 461(7266):997-1001. PMID: 19749742; PMCID: PMC2989900.
      View in: PubMed, PubMed Central
    69. Ma W, Trusina A, El-Samad H, Lim W, Tang C. Defining network topologies that can achieve biochemical adaptation. Cell. 2009 Aug 21; 138(4):760-73. PMID: 19703401; PMCID: PMC3068210.
      View in: PubMed, PubMed Central
    70. Zeke A, Lukács M, Lim W, Reményi A. Scaffolds: interaction platforms for cellular signalling circuits. Trends Cell Biol. 2009 Aug; 19(8):364-74. PMID: 19651513; PMCID: PMC3073007.
      View in: PubMed, PubMed Central
    71. Tan CS, Pasculescu A, Lim W, Pawson T, Bader GD, Linding R. Positive selection of tyrosine loss in metazoan evolution. Science. 2009 Sep 25; 325(5948):1686-8. PMID: 19589966; PMCID: PMC3066034.
      View in: PubMed, PubMed Central
    72. Beltrao P, Trinidad JC, Fiedler D, Roguev A, Lim W, Shokat KM, Burlingame AL, Krogan NJ. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol. 2009 Jun 16; 7(6):e1000134. PMID: 19547744; PMCID: PMC2691599.
      View in: PubMed, PubMed Central
    73. Good M, Tang G, Singleton J, Reményi A, Lim W. The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation. Cell. 2009 Mar 20; 136(6):1085-97. PMID: 19303851; PMCID: PMC2777755.
      View in: PubMed, PubMed Central
    74. Lim W. Frederic M Richards 1925-2009. Nat Struct Mol Biol. 2009 Mar; 16(3):230-2. PMID: 19259121.
      View in: PubMed
    75. Sallee NA, Rivera GM, Dueber JE, Vasilescu D, Mullins RD, Mayer BJ, Lim W. The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Nature. 2008 Aug 21; 454(7207):1005-8. PMID: 18650806; PMCID: PMC2749708.
      View in: PubMed, PubMed Central
    76. Pincus D, Letunic I, Bork P, Lim W. Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9680-4. PMID: 18599463; PMCID: PMC2443182.
      View in: PubMed, PubMed Central
    77. Bashor CJ, Helman NC, Yan S, Lim W. Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science. 2008 Mar 14; 319(5869):1539-43. PMID: 18339942.
      View in: PubMed
    78. King N, Westbrook MJ, Young SL, Kuo A, Abedin M, Chapman J, Fairclough S, Hellsten U, Isogai Y, Letunic I, Marr M, Pincus D, Putnam N, Rokas A, Wright KJ, Zuzow R, Dirks W, Good M, Goodstein D, Lemons D, Li W, Lyons JB, Morris A, Nichols S, Richter DJ, Salamov A, Sequencing JG, Bork P, Lim W, Manning G, Miller WT, McGinnis W, Shapiro H, Tjian R, Grigoriev IV, Rokhsar D. The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature. 2008 Feb 14; 451(7180):783-8. PMID: 18273011; PMCID: PMC2562698.
      View in: PubMed, PubMed Central
    79. Lee PJ, Helman NC, Lim W, Hung PJ. A microfluidic system for dynamic yeast cell imaging. Biotechniques. 2008 Jan; 44(1):91-5. PMID: 18254385.
      View in: PubMed
    80. Yeh BJ, Lim W. Synthetic biology: lessons from the history of synthetic organic chemistry. Nat Chem Biol. 2007 Sep; 3(9):521-5. PMID: 17710092.
      View in: PubMed
    81. Yeh BJ, Rutigliano RJ, Deb A, Bar-Sagi D, Lim W. Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature. 2007 May 31; 447(7144):596-600. PMID: 17515921.
      View in: PubMed
    82. Dueber JE, Mirsky EA, Lim W. Engineering synthetic signaling proteins with ultrasensitive input/output control. Nat Biotechnol. 2007 Jun; 25(6):660-2. PMID: 17515908.
      View in: PubMed
    83. Sallee NA, Yeh BJ, Lim W. Engineering modular protein interaction switches by sequence overlap. J Am Chem Soc. 2007 Apr 18; 129(15):4606-11. PMID: 17381089.
      View in: PubMed
    84. Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim W, Way M, Volkman BF. Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J Biol Chem. 2007 Mar 16; 282(11):8446-53. PMID: 17229736.
      View in: PubMed
    85. Hammond MC, Harris BZ, Lim W, Bartlett PA. Beta strand peptidomimetics as potent PDZ domain ligands. Chem Biol. 2006 Dec; 13(12):1247-51. PMID: 17185220.
      View in: PubMed
    86. Reményi A, Good MC, Lim W. Docking interactions in protein kinase and phosphatase networks. Curr Opin Struct Biol. 2006 Dec; 16(6):676-85. PMID: 17079133.
      View in: PubMed
    87. Bhattacharyya RP, Reményi A, Good MC, Bashor CJ, Falick AM, Lim W. The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science. 2006 Feb 10; 311(5762):822-6. PMID: 16424299.
      View in: PubMed
    88. Bhattacharyya RP, Reményi A, Yeh BJ, Lim W. Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu Rev Biochem. 2006; 75:655-80. PMID: 16756506.
      View in: PubMed
    89. Reményi A, Good MC, Bhattacharyya RP, Lim W. The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network. Mol Cell. 2005 Dec 22; 20(6):951-62. PMID: 16364919.
      View in: PubMed
    90. Petrosky KY, Ou HD, Löhr F, Dötsch V, Lim W. A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes. J Biol Chem. 2005 Nov 18; 280(46):38528-36. PMID: 16147993.
      View in: PubMed
    91. Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim W. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell. 2005 Jan 21; 17(2):181-91. PMID: 15664188.
      View in: PubMed
    92. Dueber JE, Yeh BJ, Bhattacharyya RP, Lim W. Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry. Curr Opin Struct Biol. 2004 Dec; 14(6):690-9. PMID: 15582393.
      View in: PubMed
    93. Zarrinpar A, Bhattacharyya RP, Nittler MP, Lim W. Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway. Mol Cell. 2004 Jun 18; 14(6):825-32. PMID: 15200959.
      View in: PubMed
    94. Zarrinpar A, Park SH, Lim W. Optimization of specificity in a cellular protein interaction network by negative selection. Nature. 2003 Dec 11; 426(6967):676-80. PMID: 14668868.
      View in: PubMed
    95. Dueber JE, Yeh BJ, Chak K, Lim W. Reprogramming control of an allosteric signaling switch through modular recombination. Science. 2003 Sep 26; 301(5641):1904-8. PMID: 14512628.
      View in: PubMed
    96. Carlton VE, Harris BZ, Puffenberger EG, Batta AK, Knisely AS, Robinson DL, Strauss KA, Shneider BL, Lim W, Salen G, Morton DH, Bull LN. Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT. Nat Genet. 2003 May; 34(1):91-6. PMID: 12704386.
      View in: PubMed
    97. Zarrinpar A, Bhattacharyya RP, Lim W. The structure and function of proline recognition domains. Sci STKE. 2003 Apr 22; 2003(179):RE8. PMID: 12709533.
      View in: PubMed
    98. Harris BZ, Lau FW, Fujii N, Guy RK, Lim W. Role of electrostatic interactions in PDZ domain ligand recognition. Biochemistry. 2003 Mar 18; 42(10):2797-805. PMID: 12627945.
      View in: PubMed
    99. Park SH, Zarrinpar A, Lim W. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science. 2003 Feb 14; 299(5609):1061-4. PMID: 12511654.
      View in: PubMed
    100. Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim W. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell. 2002 Nov 15; 111(4):565-76. PMID: 12437929.
      View in: PubMed
    101. Yu TW, Hao JC, Lim W, Tessier-Lavigne M, Bargmann CI. Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function. Nat Neurosci. 2002 Nov; 5(11):1147-54. PMID: 12379860.
      View in: PubMed
    102. Harris BZ, Venkatasubrahmanyam S, Lim W. Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. J Biol Chem. 2002 Sep 20; 277(38):34902-8. PMID: 12110687.
      View in: PubMed
    103. Prehoda KE, Lim W. How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2. Curr Opin Cell Biol. 2002 Apr; 14(2):149-54. PMID: 11891112.
      View in: PubMed
    104. Lim W. The modular logic of signaling proteins: building allosteric switches from simple binding domains. Curr Opin Struct Biol. 2002 Feb; 12(1):61-8. PMID: 11839491.
      View in: PubMed
    Wendell's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (417) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (41) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    ↑