Hana El-Samad, PhD

Title(s)Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address1700 4th St, #403E
San Francisco CA 94158
Phone415-476-2596
ORCID ORCID Icon0000-0001-6239-9916 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    American Automatic Control Council2011Donald P. Eckman Award
    David and Lucille Packard Foundation2009Packard Fellowship
    University of California, San Francisco2008Grace Boyer Junior Faculty Endowed Chair

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Synthetic circuits that drive infiltration of therapeutic T cells into immunologically cold tumors
    NIH U01CA265697Sep 10, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Unraveling the quantitative dynamics of cAMP-PKA signaling in yeast
    NIH R01GM119033Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Exploring Design Principles of Cellular Control Circuits
    NIH P50GM081879Sep 1, 2010 - Jul 31, 2019
    Role: Co-Investigator
    Systems Biology of Molecular Noise in Yeast
    NIH R01GM086379May 1, 2009 - Jun 28, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Myths, Legends, and Wisdom. GEN Biotechnology. 2024 Oct 1; 3(5):267-268. El-Samad EH. .
      View in: Publisher Site   Mentions:
    2. Myths, Legends, and Wisdom. GEN Biotechnology. 2024 Oct 1; 3(5):267-268. El-Samad EH. .
      View in: Publisher Site   Mentions:
    3. De novo-designed minibinders expand the synthetic biology sensing repertoire. bioRxiv. 2024 Aug 29. Weinberg ZY, Soliman SS, Kim MS, Shah DH, Chen IP, Ott M, Lim WA, El-Samad H. PMID: 38293112; PMCID: PMC10827046.
      View in: PubMed   Mentions:
    4. Degron-Based bioPROTACs for Controlling Signaling in CAR T Cells. ACS Synth Biol. 2024 Aug 16; 13(8):2313-2327. Kim MS, Bhargava HK, Shavey GE, Lim WA, El-Samad H, Ng AH. PMID: 38991546; PMCID: PMC11334183.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. AI as the New Medium of Creativity. GEN Biotechnology. 2024 Jun 1; 3(3):101-102. El-Samad EH. .
      View in: Publisher Site   Mentions:
    6. “Black-box” Data as a New Paradigm. GEN Biotechnology. 2024 Apr 1; 3(2):47-48. El-Samad EH. .
      View in: Publisher Site   Mentions:
    7. Degron-based bioPROTACs for controlling signaling in CAR T cells. bioRxiv. 2024 Feb 17. Kim MS, Bhargava HK, Shavey GE, Lim WA, El-Samad H, Ng AH. PMID: 38405763; PMCID: PMC10888892.
      View in: PubMed   Mentions:
    8. The Next Emergence of Synthetic Biology. GEN Biotechnology. 2024 Feb 1; 3(1):1-2. El-Samad EH. .
      View in: Publisher Site   Mentions:
    9. AI, Bias, and Discrimination. GEN Biotechnology. 2023 Dec 1; 2(6):445-445. El-Samad EH. .
      View in: Publisher Site   Mentions:
    10. Lessons from the Minimal Cell. GEN Biotechnology. 2023 Aug 1; 2(4):263-264. El-Samad EH. .
      View in: Publisher Site   Mentions:
    11. The Potential of Public–Private Partnerships for the Bioeconomy. GEN Biotechnology. 2023 Jun 1; 2(3):149-150. El-Samad EH. .
      View in: Publisher Site   Mentions:
    12. Strategic Thinking for Bold Goals. GEN Biotechnology. 2023 Apr 1; 2(2):59-60. El-Samad EH. .
      View in: Publisher Site   Mentions:
    13. Animal Alternatives for Drug Development. GEN Biotechnology. 2023 Feb 1; 2(1):1-2. El-Samad EH. .
      View in: Publisher Site   Mentions:
    14. Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science. 2022 12 16; 378(6625):eaba1624. Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA. PMID: 36520915; PMCID: PMC9970000.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    15. We Don't Need No Education Misinformation. GEN Biotechnology. 2022 Dec 1; 1(6):457-458. El-Samad EH. .
      View in: Publisher Site   Mentions:
    16. Mr. President, Mandate an Equitable Bioeconomy. GEN Biotechnology. 2022 Oct 1; 1(5):402-403. El-Samad EH. .
      View in: Publisher Site   Mentions:
    17. CoRa-A general approach for quantifying biological feedback control. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2206825119. Gómez-Schiavon M, El-Samad H. PMID: 36037352; PMCID: PMC9457221.
      View in: PubMed   Mentions: 2     Fields:    
    18. Basic and Applied Research Are Fruits from the Same Tree. GEN Biotechnology. 2022 Aug 1; 1(4):311-312. El-Samad EH. .
      View in: Publisher Site   Mentions:
    19. The Human Right to Our Bodies. GEN Biotechnology. 2022 Jun 1; 1(3):207-207. El-Samad EH. .
      View in: Publisher Site   Mentions:
    20. Generosity of Spirit. GEN Biotechnology. 2022 Apr 1; 1(2):113-114. El-Samad EH. .
      View in: Publisher Site   Mentions:
    21. GEN Biotechnology and the New Age of Bioinnovation. GEN Biotechnology. 2022 Feb 1; 1(1):1-2. El-Samad EH. .
      View in: Publisher Site   Mentions:
    22. The Vision for GEN Biotechnology: From Precision Biology to Engaging a Broad Audience. GEN Biotechnology. 2022 Feb 1; 1(1):21-25. El-Samad EH, Lin LF. .
      View in: Publisher Site   Mentions:
    23. Competitive Displacement of De Novo Designed HeteroDimers Can Reversibly Control Protein–Protein Interactions and Implement Feedback in Synthetic Circuits. GEN Biotechnology. 2022 Feb 1; 1(1):91-100. Nguyen NT, Dods DG, Gómez-Schiavon GM, Wu WM, Chen CZ, Kibler KR, Baker BD, El-Samad EH, Ng NA. .
      View in: Publisher Site   Mentions:
    24. De novo design of tyrosine and serine kinase-driven protein switches. Nat Struct Mol Biol. 2021 09; 28(9):762-770. Woodall NB, Weinberg Z, Park J, Busch F, Johnson RS, Feldbauer MJ, Murphy M, Ahlrichs M, Yousif I, MacCoss MJ, Wysocki VH, El-Samad H, Baker D. PMID: 34518698; PMCID: PMC8601088.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    25. Director Lander, the time is now. Science. 2021 Jul 02; 373(6550):7. Eniola-Adefeso O, El-Samad H. PMID: 34210855.
      View in: PubMed   Mentions: 1     Fields:    
    26. Biological feedback control-Respect the loops. Cell Syst. 2021 06 16; 12(6):477-487. El-Samad H. PMID: 34139160.
      View in: PubMed   Mentions: 22     Fields:    
    27. Paralogs in the PKA Regulon Traveled Different Evolutionary Routes to Divergent Expression in Budding Yeast. Front Fungal Biol. 2021; 2:642336. Heineike BM, El-Samad H. PMID: 37744115; PMCID: PMC10512328.
      View in: PubMed   Mentions: 4  
    28. Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein. bioRxiv. 2021 Apr 20. Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F, QCRG Structural Biology Consortium, Kumar GR, Ott M, Baker D, El-Samad H. PMID: 33907743; PMCID: PMC8077567.
      View in: PubMed   Mentions:
    29. Stress-induced growth rate reduction restricts metabolic resource utilization to modulate osmo-adaptation time. Cell Rep. 2021 03 16; 34(11):108854. Bonny AR, Kochanowski K, Diether M, El-Samad H. PMID: 33730573.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Fund Black scientists. Cell. 2021 02 04; 184(3):561-565. Stevens KR, Masters KS, Imoukhuede PI, Haynes KA, Setton LA, Cosgriff-Hernandez E, Lediju Bell MA, Rangamani P, Sakiyama-Elbert SE, Finley SD, Willits RK, Koppes AN, Chesler NC, Christman KL, Allen JB, Wong JY, El-Samad H, Desai TA, Eniola-Adefeso O. PMID: 33503447.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    31. Orthogonal control of mean and variability of endogenous genes in a human cell line. Nat Commun. 2021 01 12; 12(1):292. Bonny AR, Fonseca JP, Park JE, El-Samad H. PMID: 33436569; PMCID: PMC7804932.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    32. Multidimensional Characterization of Parts Enhances Modeling Accuracy in Genetic Circuits. ACS Synth Biol. 2020 11 20; 9(11):2917-2926. Gómez-Schiavon M, Dods G, El-Samad H, Ng AH. PMID: 33166452.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    33. Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics. Cell Syst. 2020 10 21; 11(4):336-353.e24. Chen SY, Osimiri LC, Chevalier M, Bugaj LJ, Nguyen TH, Greenstein RA, Ng AH, Stewart-Ornstein J, Neves LT, El-Samad H. PMID: 32898473; PMCID: PMC7648432.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. De novo design of protein logic gates. Science. 2020 04 03; 368(6486):78-84. Chen Z, Kibler RD, Hunt A, Busch F, Pearl J, Jia M, VanAernum ZL, Wicky BIM, Dods G, Liao H, Wilken MS, Ciarlo C, Green S, El-Samad H, Stamatoyannopoulos J, Wysocki VH, Jewett MC, Boyken SE, Baker D. PMID: 32241946; PMCID: PMC7397813.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    35. Multi-kinase control of environmental stress responsive transcription. PLoS One. 2020; 15(3):e0230246. Mace K, Krakowiak J, El-Samad H, Pincus D. PMID: 32160258; PMCID: PMC7065805.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Assembly of Genetic Circuits with the Mammalian ToolKit. Bio Protoc. 2020 Mar 05; 10(5):e3547. Fonseca JP, Bonny AR, Town J, El-Samad H. PMID: 33659521; PMCID: PMC7842717.
      View in: PubMed   Mentions: 3  
    37. Publisher Correction: Modular and tunable biological feedback control using a de novo protein switch. Nature. 2020 03; 579(7798):E8. Ng AH, Nguyen TH, Gómez-Schiavon M, Dods G, Langan RA, Boyken SE, Samson JA, Waldburger LM, Dueber JE, Baker D, El-Samad H. PMID: 32094663.
      View in: PubMed   Mentions: 2     Fields:    
    38. A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26918-26924. Dalal CK, Zuleta IA, Lohse MB, Zordan RE, El-Samad H, Johnson AD. PMID: 31822605; PMCID: PMC6936367.
      View in: PubMed   Mentions: 6     Fields:    
    39. A Toolkit for Rapid Modular Construction of Biological Circuits in Mammalian Cells. ACS Synth Biol. 2019 11 15; 8(11):2593-2606. Fonseca JP, Bonny AR, Kumar GR, Ng AH, Town J, Wu QC, Aslankoohi E, Chen SY, Dods G, Harrigan P, Osimiri LC, Kistler AL, El-Samad H. PMID: 31686495.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    40. Design and Analysis of a Proportional-Integral-Derivative Controller with Biological Molecules. Cell Syst. 2019 10 23; 9(4):338-353.e10. Chevalier M, Gómez-Schiavon M, Ng AH, El-Samad H. PMID: 31563473.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    41. Modular and tunable biological feedback control using a de novo protein switch. Nature. 2019 08; 572(7768):265-269. Ng AH, Nguyen TH, Gómez-Schiavon M, Dods G, Langan RA, Boyken SE, Samson JA, Waldburger LM, Dueber JE, Baker D, El-Samad H. PMID: 31341280.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    42. De novo design of bioactive protein switches. Nature. 2019 08; 572(7768):205-210. Langan RA, Boyken SE, Ng AH, Samson JA, Dods G, Westbrook AM, Nguyen TH, Lajoie MJ, Chen Z, Berger S, Mulligan VK, Dueber JE, Novak WRP, El-Samad H, Baker D. PMID: 31341284; PMCID: PMC6733528.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    43. Synthetic transcriptional synergy. Science. 2019 05 10; 364(6440):531-532. Ng AH, El-Samad H. PMID: 31073055.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    44. Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs. Nat Commun. 2019 May 09; 10(1):2127. Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. PMID: 31073154; PMCID: PMC6509140.
      View in: PubMed   Mentions: 66     Fields:    
    45. Control Theoretical Concepts for Synthetic and Systems Biology. Current Opinion in Systems Biology. 2019 Apr 1; 14(ACS Synthetic Biology 7 5 2018):50-57. Baetica BA, Westbrook WA, El-Samad EH. .
      View in: Publisher Site   Mentions:
    46. Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control. Cell. 2018 10 18; 175(3):877-886.e10. Harrigan P, Madhani HD, El-Samad H. PMID: 30340045; PMCID: PMC6258208.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    47. Complexity-aware simple modeling. Curr Opin Microbiol. 2018 10; 45:47-52. Gómez-Schiavon M, El-Samad H. PMID: 29494832.
      View in: PubMed   Mentions: 2     Fields:    
    48. Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast. ACS Synth Biol. 2017 03 17; 6(3):545-554. Aranda-Díaz A, Mace K, Zuleta I, Harrigan P, El-Samad H. PMID: 27930885; PMCID: PMC5507677.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    49. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell. 2017 01 01; 28(1):221-227. Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman JS, El-Samad H. PMID: 28035051; PMCID: PMC5221627.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    50. Transcriptional rewiring over evolutionary timescales changes quantitative and qualitative properties of gene expression. Elife. 2016 09 10; 5. Dalal CK, Zuleta IA, Mitchell KF, Andes DR, El-Samad H, Johnson AD. PMID: 27614020; PMCID: PMC5067116.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    51. Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics. PLoS One. 2016; 11(8):e0159292. Al-Sady B, Greenstein RA, El-Samad HJ, Braun S, Madhani HD. PMID: 27479698; PMCID: PMC4968791.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    52. TRADEOFFS IN ADAPTING BIOLOGICAL SYSTEMS. Eur J Control. 2016 Jul; 30:68-75. Bhatnagar R, El-Samad H. PMID: 33100592; PMCID: PMC7584344.
      View in: PubMed   Mentions: 2  
    53. Low Dimensionality in Gene Expression Data Enables the Accurate Extraction of Transcriptional Programs from Shallow Sequencing. Cell Syst. 2016 04 27; 2(4):239-250. Heimberg G, Bhatnagar R, El-Samad H, Thomson M. PMID: 27135536; PMCID: PMC4856162.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    54. The Impact of Different Sources of Fluctuations on Mutual Information in Biochemical Networks. PLoS Comput Biol. 2015 Oct; 11(10):e1004462. Chevalier M, Venturelli O, El-Samad H. PMID: 26484538; PMCID: PMC4615624.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    55. Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):11977-82. Yang J, McCormick MA, Zheng J, Xie Z, Tsuchiya M, Tsuchiyama S, El-Samad H, Ouyang Q, Kaeberlein M, Kennedy BK, Li H. PMID: 26351681; PMCID: PMC4586869.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    56. Population diversification in a yeast metabolic program promotes anticipation of environmental shifts. PLoS Biol. 2015 Jan; 13(1):e1002042. Venturelli OS, Zuleta I, Murray RM, El-Samad H. PMID: 25626086; PMCID: PMC4307983.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    57. A master equation and moment approach for biochemical systems with creation-time-dependent bimolecular rate functions. J Chem Phys. 2014 Dec 07; 141(21):214108. Chevalier MW, El-Samad H. PMID: 25481130; PMCID: PMC4257977.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    58. Delayed Ras/PKA signaling augments the unfolded protein response. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14800-5. Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. PMID: 25275008; PMCID: PMC4205644.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    59. Multicellular architecture of malignant breast epithelia influences mechanics. PLoS One. 2014; 9(8):e101955. Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH. PMID: 25111489; PMCID: PMC4128597.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    60. Using dynamic noise propagation to infer causal regulatory relationships in biochemical networks. ACS Synth Biol. 2015 Mar 20; 4(3):258-64. Lipinski-Kruszka J, Stewart-Ornstein J, Chevalier MW, El-Samad H. PMID: 24967515; PMCID: PMC4384829.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    61. Dynamic characterization of growth and gene expression using high-throughput automated flow cytometry. Nat Methods. 2014 Apr; 11(4):443-8. Zuleta IA, Aranda-Díaz A, Li H, El-Samad H. PMID: 24608180; PMCID: PMC4016179.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    62. Sensitivity Analysis and Model Reduction Applied to Adapting Biological Systems. Biophysical Journal. 2014 Jan 1; 106(2):377a. Bhatnagar BR, El-Samad EH. .
      View in: Publisher Site   Mentions:
    63. Msn2 coordinates a stoichiometric gene expression program. Curr Biol. 2013 Dec 02; 23(23):2336-45. Stewart-Ornstein J, Nelson C, DeRisi J, Weissman JS, El-Samad H. PMID: 24210615; PMCID: PMC4072881.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    64. Building robust functionality in synthetic circuits using engineered feedback regulation. Curr Opin Biotechnol. 2013 Aug; 24(4):790-6. Chen S, Harrigan P, Heineike B, Stewart-Ornstein J, El-Samad H. PMID: 23566378; PMCID: PMC3732497.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    65. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013 Mar 28; 495(7442):534-8. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. PMID: 23515162; PMCID: PMC3835555.
      View in: PubMed   Mentions: 388     Fields:    Translation:HumansCells
    66. Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress. Cell Rep. 2013 Feb 21; 3(2):328-34. Vidal SE, Pincus D, Stewart-Ornstein J, El-Samad H. PMID: 23416049; PMCID: PMC3616637.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    67. Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):E3324-33. Venturelli OS, El-Samad H, Murray RM. PMID: 23150580; PMCID: PMC3511703.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    68. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):E3084-93. Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL. PMID: 23054834; PMCID: PMC3494901.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    69. Towards a minimal stochastic model for a large class of diffusion-reactions on biological membranes. J Chem Phys. 2012 Aug 28; 137(8):084103. Chevalier MW, El-Samad H. PMID: 22938214; PMCID: PMC3436915.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    70. Modeling and simulation of cellular functions. Molecular Biology of the Cell. 2012 Mar 15; 23(6):972-972. Paluch PE, El-Samad EH. .
      View in: Publisher Site   Mentions:
    71. Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae. Mol Cell. 2012 Feb 24; 45(4):483-93. Stewart-Ornstein J, Weissman JS, El-Samad H. PMID: 22365828; PMCID: PMC3327736.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    72. Stochastic modeling of cellular networks. Methods Cell Biol. 2012; 110:111-37. Stewart-Ornstein J, El-Samad H. PMID: 22482947.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    73. Genetics: Noise rules. Nature. 2011 Dec 07; 480(7376):188-9. El-Samad H, Weissman JS. PMID: 22158239.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    74. A data-integrated method for analyzing stochastic biochemical networks. J Chem Phys. 2011 Dec 07; 135(21):214110. Chevalier MW, El-Samad H. PMID: 22149782; PMCID: PMC3324259.
      View in: PubMed   Mentions: 3     Fields:    
    75. In silico feedback for in vivo regulation of a gene expression circuit. Nat Biotechnol. 2011 Nov 06; 29(12):1114-6. Milias-Argeitis A, Summers S, Stewart-Ornstein J, Zuleta I, Pincus D, El-Samad H, Khammash M, Lygeros J. PMID: 22057053; PMCID: PMC4565053.
      View in: PubMed   Mentions: 83     Fields:    Translation:Animals
    76. Can a systems perspective help us appreciate the biological meaning of small effects? Dev Cell. 2011 Jul 19; 21(1):11-3. El-Samad H, Madhani HD. PMID: 21763599; PMCID: PMC3615985.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    77. Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J Cell Biol. 2011 Apr 04; 193(1):171-84. Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P. PMID: 21444684; PMCID: PMC3082176.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    78. Homeostatic Regulation of the Unfolded Protein Response. Biophysical Journal. 2011 Feb 1; 100(3):170a. El-Samad EH. .
      View in: Publisher Site   Mentions:
    79. Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat Cell Biol. 2010 Oct; 12(10):954-62. McCullagh E, Seshan A, El-Samad H, Madhani HD. PMID: 20852627; PMCID: PMC2948760.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    80. Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions. Genes Dev. 2010 Aug 15; 24(16):1758-71. Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD. PMID: 20675407; PMCID: PMC2922504.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    81. BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLoS Biol. 2010 Jul 06; 8(7):e1000415. Pincus D, Chevalier MW, Aragón T, van Anken E, Vidal SE, El-Samad H, Walter P. PMID: 20625545; PMCID: PMC2897766.
      View in: PubMed   Mentions: 225     Fields:    Translation:AnimalsCells
    82. Discriminating between rival biochemical network models: three approaches to optimal experiment design. BMC Syst Biol. 2010 Apr 01; 4:38. Mélykúti B, August E, Papachristodoulou A, El-Samad H. PMID: 20356406; PMCID: PMC2873315.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    83. Defining network topologies that can achieve biochemical adaptation. The FASEB Journal. 2010 Apr 1; 24:190.1-190.1. Tang TC, Ma MW, Trusina TA, El-Samad EH, Lim LW. .
      View in: Publisher Site   Mentions:
    84. Modelling and analysis of gene regulatory network using feedback control theory. International Journal of Systems Science. 2010 Jan 1; 41(1):17-33. El-Samad EH, Khammash KM. .
      View in: Publisher Site   Mentions:
    85. Not all quiet on the noise front. Nat Chem Biol. 2009 Oct; 5(10):699-704. McCullagh E, Farlow J, Fuller C, Girard J, Lipinski-Kruszka J, Lu D, Noriega T, Rollins G, Spitzer R, Todhunter M, El-Samad H. PMID: 19763097.
      View in: PubMed   Mentions: 6     Fields:    
    86. Defining network topologies that can achieve biochemical adaptation. Cell. 2009 Aug 21; 138(4):760-73. Ma W, Trusina A, El-Samad H, Lim WA, Tang C. PMID: 19703401; PMCID: PMC3068210.
      View in: PubMed   Mentions: 392     Fields:    Translation:Cells
    87. A rigorous framework for multiscale simulation of stochastic cellular networks. J Chem Phys. 2009 Aug 07; 131(5):054102. Chevalier MW, El-Samad H. PMID: 19673546; PMCID: PMC2736569.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    88. Tuning the activation threshold of a kinase network by nested feedback loops. Science. 2009 Apr 24; 324(5926):509-12. Justman QA, Serber Z, Ferrell JE, El-Samad H, Shokat KM. PMID: 19390045; PMCID: PMC2880456.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    89. Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13349-54. Herzmark P, Campbell K, Wang F, Wong K, El-Samad H, Groisman A, Bourne HR. PMID: 17684096; PMCID: PMC1940227.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    90. 9. Digital Filter Stepsize Control in DASPK and Its Effect on Control Optimization Performance. Real-Time PDE-Constrained Optimization. 2007 Jan 1; 183-195. Meeker MK, Homescu HC, Petzold PL, El-Samad EH, Khammash KM, Söderlind SG. .
      View in: Publisher Site   Mentions:
    91. Module-based analysis of robustness tradeoffs in the heat shock response system. PLoS Comput Biol. 2006 Jul 28; 2(7):e59. Kurata H, El-Samad H, Iwasaki R, Ohtake H, Doyle JC, Grigorova I, Gross CA, Khammash M. PMID: 16863396; PMCID: PMC1523291.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    92. Advanced Methods and Algorithms for Biological Networks Analysis. Proceedings of the IEEE. 2006 Apr 1; 94(4):832-853. El-Samad EH, Prajna PS, Papachristodoulou PA, Doyle DJ, Khammash KM. .
      View in: Publisher Site   Mentions:
    93. Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks. Biophys J. 2006 May 15; 90(10):3749-61. El-Samad H, Khammash M. PMID: 16500958; PMCID: PMC1440756.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    94. Surviving heat shock: control strategies for robustness and performance. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2736-41. El-Samad H, Kurata H, Doyle JC, Gross CA, Khammash M. PMID: 15668395; PMCID: PMC549435.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    95. Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System. PLoS Computational Biology. 2005 Jan 1; preprint(2006):e59. Kurata KH, El-Samad EH, Iwasaki IR, Ohtake OH, Doyle DJ, Grigorova GI, Gross GC, Khammash KM. .
      View in: Publisher Site   Mentions:
    96. Systems biology: from physiology to gene regulation. IEEE Control Systems Magazine. 2004 Aug 1; 24(4):62-76. Khammash KM, El-Samad EH. .
      View in: Publisher Site   Mentions:
    97. Feedback Regulation of the Heat Shock Response in E. coli. Multidisciplinary Research in Control. 2003 Jan 1; 289:115-128. El-Samad EH, Khammash KM, Kurata KH, Doyle DJ. .
      View in: Publisher Site   Mentions:
    98. Calcium homeostasis and parturient hypocalcemia: an integral feedback perspective. J Theor Biol. 2002 Jan 07; 214(1):17-29. El-Samad H, Goff JP, Khammash M. PMID: 11786029.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    Hana's Networks
    Concepts (269)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (31)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSF Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).

    We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use. This site is running Profiles RNS version UCSF-v3.1.0-6-g69de2244 on PROFILES-PWEB03.

    Copyright © The Regents of the University of California.