Chao Tang, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
AddressLocation Required
Varies CA 00000
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    Collapse Biography 
    Collapse Awards and Honors
    University of Chicago1982  - 1982Valentine Telegdi Prize, University of Chicago
    American Physical Society1997  - 1997Fellow, the American Physical Society
    OverseaNational Science Foundation of China2002  - 2002Overseas Chinese Young Scholars Award, National Science Foundation of China
    Troisième2003  - 2003Troisième Cycle Lecture, Lausanne, Switzerland
    Chinese Ministry of Education2003  - 2003Chang Jiang Scholar Award, Chinese Ministry of Education
    Chinese University of Hong Kong2006  - 2006Croucher Lecture, Chinese University of Hong Kong
    2011  - 2011China Thousand Talent Program

    Collapse Overview 
    Collapse Overview
    We are a Systems Biology lab. We are interested in quantitative studies of biological systems, applying and developing quantitative methods and tools to address key biological questions. We believe that an interdisciplinary approach focusing on quantitative questions at a systems level will uncover new biological principles and help us to better understand complex disease and design new therapeutic strategies. The lab has both wet and dry components. Some of our current projects include: yeast cell cycle regulation, stress response, the function and topology of biological networks, modeling cancer pathways and development, systems drug design, and theoretical issues in systems biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Quantitative studies of cell cycle checkpoints and switches
    NIH R01GM097115Aug 8, 2011 - May 31, 2015
    Role: Principal Investigator
    Exploring Design Principles of Cellular Control Circuits
    NIH P50GM081879Sep 1, 2010 - Jul 31, 2019
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intermedin1-53 attenuates atherosclerotic plaque vulnerability by inhibiting CHOP-mediated apoptosis and inflammasome in macrophages. Cell Death Dis. 2021 May 01; 12(5):436. Ren JL, Chen Y, Zhang LS, Zhang YR, Liu SM, Yu YR, Jia MZ, Tang CS, Qi YF, Lu WW. PMID: 33934111.
      View in: PubMed   Mentions:    Fields:    
    2. Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway. Aging (Albany NY). 2021 Feb 01; 12. Ni XQ, Zhang YR, Jia LX, Lu WW, Zhu Q, Ren JL, Chen Y, Zhang LS, Liu X, Yu YR, Jia MZ, Ning ZP, Du J, Tang CS, Qi YF. PMID: 33535178.
      View in: PubMed   Mentions:    Fields:    
    3. Cartilage oligomeric matrix protein is an endogenous ß-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. Cell Res. 2021 Jan 28. Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J, Kong W. PMID: 33510386.
      View in: PubMed   Mentions:    Fields:    
    4. CD4+ T-Cell Endogenous Cystathionine ? Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation. Circulation. 2020 Nov 03; 142(18):1752-1769. Cui C, Fan J, Zeng Q, Cai J, Chen Y, Chen Z, Wang W, Li SY, Cui Q, Yang J, Tang C, Xu G, Cai J, Geng B. PMID: 32900241.
      View in: PubMed   Mentions:    Fields:    
    5. Intermedin alleviates pathological cardiac remodeling by upregulating klotho. Pharmacol Res. 2020 09; 159:104926. Zhang LS, Liu Y, Chen Y, Ren JL, Zhang YR, Yu YR, Jia MZ, Ning ZP, Du J, Tang CS, Qi YF. PMID: 32502636.
      View in: PubMed   Mentions:    Fields:    
    6. Intermedin1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1. Aging (Albany NY). 2020 03 31; 12(7):5651-5674. Chen Y, Zhang LS, Ren JL, Zhang YR, Wu N, Jia MZ, Yu YR, Ning ZP, Tang CS, Qi YF. PMID: 32229709.
      View in: PubMed   Mentions: 1     Fields:    
    7. Intermedin1-53 Ameliorates Homocysteine-Promoted Atherosclerotic Calcification by Inhibiting Endoplasmic Reticulum Stress. J Cardiovasc Pharmacol Ther. 2020 05; 25(3):251-264. Ren JL, Hou YL, Ni XQ, Zhu Q, Chen Y, Zhang LS, Liu X, Xue CD, Wu N, Yu YR, Tang CS, Ning ZP, Chai SB, Qi YF. PMID: 31698947.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Endogenous intermedin protects against intimal hyperplasia by inhibiting endoplasmic reticulum stress. Peptides. 2019 11; 121:170131. Xue CD, Chen Y, Ren JL, Zhang LS, Liu X, Yu YR, Tang CS, Qi YF. PMID: 31408662.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE KO Mice. Endocrine. 2018 10; 62(1):90-106. Ni XQ, Lu WW, Zhang JS, Zhu Q, Ren JL, Yu YR, Liu XY, Wang XJ, Han M, Jing Q, Du J, Tang CS, Qi YF. PMID: 29943223.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Intermedin reduces neointima formation by regulating vascular smooth muscle cell phenotype via cAMP/PKA pathway. Atherosclerosis. 2017 Nov; 266:212-222. Zhu Q, Ni XQ, Lu WW, Zhang JS, Ren JL, Wu D, Chen Y, Zhang LS, Yu YR, Tang CS, Qi YF. PMID: 29053988.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Intermedin1-53 Attenuates Abdominal Aortic Aneurysm by Inhibiting Oxidative Stress. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2176-2190. Lu WW, Jia LX, Ni XQ, Zhao L, Chang JR, Zhang JS, Hou YL, Zhu Y, Guan YF, Yu YR, Du J, Tang CS, Qi YF. PMID: 27634835.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of a-Klotho. Kidney Int. 2016 Mar; 89(3):586-600. Chang JR, Guo J, Wang Y, Hou YL, Lu WW, Zhang JS, Yu YR, Xu MJ, Liu XY, Wang XJ, Guan YF, Zhu Y, Du J, Tang CS, Qi YF. PMID: 26880455.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase. J Hypertens. 2015 Aug; 33(8):1676-87. Lu WW, Zhao L, Zhang JS, Hou YL, Yu YR, Jia MZ, Tang CS, Qi YF. PMID: 26136070.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Impaired regulator of G protein signaling 2 transcription facilitates vascular remodeling in injured rat aorta. J Cardiovasc Med (Hagerstown). 2014 Jul; 15(7):572-8. Mao Y, Su J, Lei L, Meng L, Qi Y, Huo Y, Tang C. PMID: 24914635.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. Cardiac sympathetic afferent reflex response to intermedin microinjection into paraventricular nucleus is mediated by nitric oxide and ?-amino butyric acid in hypertensive rats. Exp Biol Med (Maywood). 2014 Oct; 239(10):1352-9. Zhou H, Sun HJ, Chang JR, Ding L, Gao Q, Tang CS, Zhu GQ, Zhou YB. PMID: 24872434.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    16. Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA. Cardiovasc Res. 2014 Feb 01; 101(2):297-305. Dai XY, Cai Y, Sun W, Ding Y, Wang W, Kong W, Tang C, Zhu Y, Xu MJ, Wang X. PMID: 24253523.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. Brg1-dependent epigenetic control of vascular smooth muscle cell proliferation by hydrogen sulfide. Biochim Biophys Acta. 2013 Jun; 1833(6):1347-55. Li L, Liu D, Bu D, Chen S, Wu J, Tang C, Du J, Jin H. PMID: 23499876.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    18. Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice. J Mol Cell Cardiol. 2012 Oct; 53(4):509-20. Dai XY, Cai Y, Mao DD, Qi YF, Tang C, Xu Q, Zhu Y, Xu MJ, Wang X. PMID: 22841663.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    19. Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1-53 attenuating myocardial oxidative stress injury induced by ischemia/reperfusion. Peptides. 2012 Feb; 33(2):329-35. Zhao L, Peng DQ, Zhang J, Song JQ, Teng X, Yu YR, Tang CS, Qi YF. PMID: 22244813.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    20. Endogenous aldosterone is involved in vascular calcification in rat. Exp Biol Med (Maywood). 2012 Jan; 237(1):31-7. Wu SY, Yu YR, Cai Y, Jia LX, Wang X, Xiao CS, Tang CS, Qi YF. PMID: 22185918.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    21. [The endocrine function of the skeleton]. Sheng Li Ke Xue Jin Zhan. 2010 Aug; 41(4):248-55. Duan XH, Qu XX, Chang JR, Qi YF, Tang CS. PMID: 21416939.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Adrenomedullin ameliorates the development of atherosclerosis in apoE-/- mice. Peptides. 2010 Jun; 31(6):1150-8. Pan CS, Zhang J, Yu F, Teng X, Cao CQ, Wu W, Tang CS, Qi YF. PMID: 20332006.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    23. Apelin antagonizes myocardial impairment in sepsis. J Card Fail. 2010 Jul; 16(7):609-17. Pan CS, Teng X, Zhang J, Cai Y, Zhao J, Wu W, Wang X, Tang CS, Qi YF. PMID: 20610237.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Defining network topologies that can achieve biochemical adaptation. Cell. 2009 Aug 21; 138(4):760-73. Ma W, Trusina A, El-Samad H, Lim WA, Tang C. PMID: 19703401.
      View in: PubMed   Mentions: 267     Fields:    Translation:Cells
    25. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. Trusina A, Papa FR, Tang C. PMID: 19075238.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    26. Sodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Heart Vessels. 2008 Nov; 23(6):409-19. Li X, Du J, Jin H, Geng B, Tang C. PMID: 19037589.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    27. Finding multiple target optimal intervention in disease-related molecular network. Mol Syst Biol. 2008; 4:228. Yang K, Bai H, Ouyang Q, Lai L, Tang C. PMID: 18985027.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    28. [Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008 Aug 19; 88(32):2235-9. Jin HF, Liang C, Liang JM, Tang CS, DU JB. PMID: 19087668.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    29. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008 Jul 04; 321(5885):126-9. Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE. PMID: 18599789.
      View in: PubMed   Mentions: 219     Fields:    Translation:Animals
    30. SCUMBLE: a method for systematic and accurate detection of codon usage bias by maximum likelihood estimation. Nucleic Acids Res. 2008 Jun; 36(11):3819-27. Kloster M, Tang C. PMID: 18495752.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    31. Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents. Med Sci Monit. 2008 Apr; 14(4):CR199-203. Zhang Q, Jin H, Wang L, Chen J, Tang C, Du J. PMID: 18376348.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    32. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9018-23. Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. PMID: 17495027.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    33. Function constrains network architecture and dynamics: a case study on the yeast cell cycle Boolean network. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May; 75(5 Pt 1):051907. Lau KY, Ganguli S, Tang C. PMID: 17677098.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    34. JNK-AP-1 pathway involved in interleukin-1beta-induced calcitonin gene-related peptide secretion in human type II alveolar epithelial cells. Peptides. 2007 Jun; 28(6):1252-9. Li W, Zheng S, Tang C, Zhu Y, Wang X. PMID: 17481780.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    35. Robustness and modular design of the Drosophila segment polarity network. Mol Syst Biol. 2006; 2:70. Ma W, Lai L, Ouyang Q, Tang C. PMID: 17170765.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    36. Dynamic studies of scaffold-dependent mating pathway in yeast. Biophys J. 2006 Dec 01; 91(11):3986-4001. Shao D, Zheng W, Qiu W, Ouyang Q, Tang C. PMID: 16980360.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    37. Sodium hydrosulfide alleviated pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Acta Pharmacol Sin. 2006 Aug; 27(8):971-80. Li XH, Du JB, Bu DF, Tang XY, Tang CS. PMID: 16867247.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. Upregulation of aldose reductase by homocysteine in type II alveolar epithelial cells. Biochem Biophys Res Commun. 2005 Dec 02; 337(4):1084-91. Jiang H, Wang XF, Fang L, Tang C, Zhu Y, Wang X. PMID: 16225842.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    39. Finding regulatory modules through large-scale gene-expression data analysis. Bioinformatics. 2005 Apr 01; 21(7):1172-9. Kloster M, Tang C, Wingreen NS. PMID: 15513996.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    40. The yeast cell-cycle network is robustly designed. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4781-6. Li F, Long T, Lu Y, Ouyang Q, Tang C. PMID: 15037758.
      View in: PubMed   Mentions: 257     Fields:    Translation:Animals
    41. Protective effect of taurine on hypochlorous acid toxicity to nuclear nucleoside triphosphatase in isolated nuclei from rat liver. World J Gastroenterol. 2004 Mar 01; 10(5):694-8. Li JX, Pang YZ, Tang CS, Li ZQ. PMID: 14991940.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    42. Simulation and analysis of in vitro DNA evolution. Phys Rev Lett. 2004 Jan 23; 92(3):038101. Kloster M, Tang C. PMID: 14753913.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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