Chao Tang, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
AddressLocation Required, #001
Varies CA 00000
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    Collapse Biography 
    Collapse Awards and Honors
    University of Chicago1982  - 1982Valentine Telegdi Prize, University of Chicago
    American Physical Society1997  - 1997Fellow, the American Physical Society
    OverseaNational Science Foundation of China2002  - 2002Overseas Chinese Young Scholars Award, National Science Foundation of China
    Troisième2003  - 2003Troisième Cycle Lecture, Lausanne, Switzerland
    Chinese Ministry of Education2003  - 2003Chang Jiang Scholar Award, Chinese Ministry of Education
    Chinese University of Hong Kong2006  - 2006Croucher Lecture, Chinese University of Hong Kong
    2011  - 2011China Thousand Talent Program

    Collapse Overview 
    Collapse Overview
    We are a Systems Biology lab. We are interested in quantitative studies of biological systems, applying and developing quantitative methods and tools to address key biological questions. We believe that an interdisciplinary approach focusing on quantitative questions at a systems level will uncover new biological principles and help us to better understand complex disease and design new therapeutic strategies. The lab has both wet and dry components. Some of our current projects include: yeast cell cycle regulation, stress response, the function and topology of biological networks, modeling cancer pathways and development, systems drug design, and theoretical issues in systems biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Quantitative studies of cell cycle checkpoints and switches
    NIH R01GM097115Aug 8, 2011 - May 31, 2015
    Role: Principal Investigator
    Exploring Design Principles of Cellular Control Circuits
    NIH P50GM081879Sep 1, 2010 - Jul 31, 2019
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Defining network topologies that can achieve biochemical adaptation. Cell. 2009 Aug 21; 138(4):760-73. Ma W, Trusina A, El-Samad H, Lim WA, Tang C. PMID: 19703401; PMCID: PMC3068210.
      View in: PubMed   Mentions: 376     Fields:    Translation:Cells
    2. Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20280-5. Trusina A, Papa FR, Tang C. PMID: 19075238; PMCID: PMC2603256.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    3. Finding multiple target optimal intervention in disease-related molecular network. Mol Syst Biol. 2008; 4:228. Yang K, Bai H, Ouyang Q, Lai L, Tang C. PMID: 18985027; PMCID: PMC2673713.
      View in: PubMed   Mentions: 69     Fields:    Translation:Humans
    4. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science. 2008 Jul 04; 321(5885):126-9. Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE. PMID: 18599789; PMCID: PMC2728800.
      View in: PubMed   Mentions: 272     Fields:    Translation:Animals
    5. SCUMBLE: a method for systematic and accurate detection of codon usage bias by maximum likelihood estimation. Nucleic Acids Res. 2008 Jun; 36(11):3819-27. Kloster M, Tang C. PMID: 18495752; PMCID: PMC2441815.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    6. Function constrains network architecture and dynamics: a case study on the yeast cell cycle Boolean network. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May; 75(5 Pt 1):051907. Lau KY, Ganguli S, Tang C. PMID: 17677098.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    7. Robustness and modular design of the Drosophila segment polarity network. Mol Syst Biol. 2006; 2:70. Ma W, Lai L, Ouyang Q, Tang C. PMID: 17170765; PMCID: PMC1762089.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    8. Dynamic studies of scaffold-dependent mating pathway in yeast. Biophys J. 2006 Dec 01; 91(11):3986-4001. Shao D, Zheng W, Qiu W, Ouyang Q, Tang C. PMID: 16980360; PMCID: PMC1635675.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    9. Finding regulatory modules through large-scale gene-expression data analysis. Bioinformatics. 2005 Apr 01; 21(7):1172-9. Kloster M, Tang C, Wingreen NS. PMID: 15513996.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    10. The yeast cell-cycle network is robustly designed. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4781-6. Li F, Long T, Lu Y, Ouyang Q, Tang C. PMID: 15037758; PMCID: PMC387325.
      View in: PubMed   Mentions: 308     Fields:    Translation:Animals
    11. Simulation and analysis of in vitro DNA evolution. Phys Rev Lett. 2004 Jan 23; 92(3):038101. Kloster M, Tang C. PMID: 14753913.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
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