David Gardner • UCSF Profiles

David Gardner, MD

Title(s)	Professor , Medicine
School	School of Medicine
Address	513 Parnassus Avenue, HSW, #1131 San Francisco CA 94143
Phone	415-476-1364
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Overview

Websites

Clinical Profile at UCSF Medical Center

Research

Research Activities and Funding

Regulation of ANP Receptor Activity in Vascular Cells
NIH R01HL045637Jul 1, 1992 - Feb 28, 2013
Role: Principal Investigator

EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
NIH R01HL035753Sep 30, 1985 - Jun 30, 2004
Role: Principal Investigator

BIOMEDICAL RESEARCH SUPPORT GRANT
NIH S07RR005890Apr 1, 1983 - Mar 31, 1991
Role: Principal Investigator

ORNG Applications

Academic Senate

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. PMID: 27217488; PMCID: PMC5001188.

View in: PubMed Mentions: 22 Fields:
End Endocrinology
Translation:Animals Cells
Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse. J Steroid Biochem Mol Biol. 2016 11; 164:292-298. Glenn DJ, Cardema MC, Gardner DG. PMID: 26429397.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Animals Cells
Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance. J Steroid Biochem Mol Biol. 2016 11; 164:281-286. Ni W, Glenn DJ, Gardner DG. PMID: 26369613; PMCID: PMC4788578.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Animals Cells
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function. PLoS One. 2015; 10(7):e0131539. Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM. PMID: 26134669; PMCID: PMC4489761.

View in: PubMed Mentions: 28 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Cardiac steatosis potentiates angiotensin II effects in the heart. Am J Physiol Heart Circ Physiol. 2015 Feb 15; 308(4):H339-50. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. PMID: 25485904; PMCID: PMC4329483.

View in: PubMed Mentions: 17 Fields:
Car Cardiology Phy Physiology
Translation:Animals Cells
Elimination of vitamin D receptor in vascular endothelial cells alters vascular function. Hypertension. 2014 Dec; 64(6):1290-8. Ni W, Watts SW, Ng M, Chen S, Glenn DJ, Gardner DG. PMID: 25201890; PMCID: PMC4430199.

View in: PubMed Mentions: 70 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Vitamin D and the heart. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 01; 305(9):R969-77. Gardner DG, Chen S, Glenn DJ. PMID: 24026071; PMCID: PMC3840320.

View in: PubMed Mentions: 31 Fields:
Phy Physiology
Translation:Humans Animals Cells
Vitamin D: beyond bone. Ann N Y Acad Sci. 2013 May; 1287:45-58. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. PMID: 23682710; PMCID: PMC3717170.

View in: PubMed Mentions: 106 Fields:
Sci Science
Translation:Humans Animals Cells
Acute liver failure with thyrotoxicosis treated with liver transplantation. Endocr Pract. 2013 May-Jun; 19(3):e57-60. Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK. PMID: 23337142.

View in: PubMed Mentions: 1 Fields:
End Endocrinology
Translation:Humans
Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart. J Steroid Biochem Mol Biol. 2013 Jul; 136:150-5. Chen S, Gardner DG. PMID: 22989481.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Animals Cells
Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide. Endocr Relat Cancer. 2012 Aug; 19(4):497-508. Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JA, McNeilly AS, Fowkes RC. PMID: 22645228.

View in: PubMed Mentions: 10 Fields:
End Endocrinology Neo Neoplasms
Translation:Humans Animals Cells
Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats. Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F141-9. Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E. PMID: 21957179.

View in: PubMed Mentions: 33 Fields:
Nep Nephrology Phy Physiology
Translation:Animals
Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011 Oct 25; 124(17):1838-47. Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG. PMID: 21947295; PMCID: PMC4160312.

View in: PubMed Mentions: 154 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals Cells
A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. PMID: 21220706; PMCID: PMC3322545.

View in: PubMed Mentions: 40 Fields:
Vas Vascular Diseases
Translation:Animals Cells
Chapter 31 Vitamin D and the Cardiovascular System. Vitamin D. 2011 Jan 1; 541-563. Gardner GD, Chen CS, Glenn GD, Ni NW. .

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A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation. J Steroid Biochem Mol Biol. 2010 Nov; 122(5):326-32. Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG. PMID: 20813185; PMCID: PMC4143149.

View in: PubMed Mentions: 13 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Animals Cells
Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity. J Steroid Biochem Mol Biol. 2010 Feb 15; 118(3):135-41. Chen S, Law CS, Gardner DG. PMID: 19961935; PMCID: PMC2830853.

View in: PubMed Mentions: 28 Fields:
Bio Biochemistry Mol Molecular Biology
Translation:Animals Cells
Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism. Cardiovasc Res. 2009 Nov 01; 84(2):209-17. Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG. PMID: 19546173; PMCID: PMC2761198.

View in: PubMed Mentions: 18 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals Cells
Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest. 2009 Jun; 119(6):1647-58. Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG. PMID: 19436108; PMCID: PMC2689130.

View in: PubMed Mentions: 31 Fields:
Med Medicine (General)
Translation:Animals Cells
Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2. Hypertension. 2009 Mar; 53(3):549-55. Glenn DJ, Wang F, Chen S, Nishimoto M, Gardner DG. PMID: 19139378; PMCID: PMC2710878.

View in: PubMed Mentions: 23 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Expression of the vitamin d receptor is increased in the hypertrophic heart. Hypertension. 2008 Dec; 52(6):1106-12. Chen S, Glenn DJ, Ni W, Grigsby CL, Olsen K, Nishimoto M, Law CS, Gardner DG. PMID: 18936343; PMCID: PMC2690395.

View in: PubMed Mentions: 68 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Lipids and the heart: neither feast nor famine. Hypertension. 2007 Sep; 50(3):463-4. Glenn DJ, Gardner DG. PMID: 17664386.

View in: PubMed Mentions: 1 Fields:
Vas Vascular Diseases
Translation:Humans Animals
Molecular biology of the natriuretic peptide system: implications for physiology and hypertension. Hypertension. 2007 Mar; 49(3):419-26. Gardner DG, Chen S, Glenn DJ, Grigsby CL. PMID: 17283251.

View in: PubMed Mentions: 45 Fields:
Vas Vascular Diseases
Translation:Humans Cells
Molecular aspects of the natriuretic peptide system. Molecular Mechanisms in Hypertension. 2006 Apr 19; 199-209. Gardner GD, Chen CS, Rahmutula RD, Wang WF, Olsen OK. .

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Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH. Neurocrit Care. 2006; 5(3):180-5. Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG. PMID: 17290085.

View in: PubMed Mentions: 21 Fields:
Cri Critical Care Neu Neurology
Translation:Humans
A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation. Hypertension. 2006 Feb; 47(2):252-8. Chen S, Qiong Y, Gardner DG. PMID: 16365184.

View in: PubMed Mentions: 15 Fields:
Vas Vascular Diseases
Translation:Animals Cells
C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Endocrinology. 2005 Nov; 146(11):4968-74. Rahmutula D, Gardner DG. PMID: 16109786.

View in: PubMed Mentions: 6 Fields:
End Endocrinology
Translation:Animals Cells
1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005 Jun 30; 128(3):197-202. Chen S, Nakamura K, Gardner DG. PMID: 15837528.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells. J Am Soc Nephrol. 2005 Feb; 16(2):329-39. Chen S, Ni XP, Humphreys MH, Gardner DG. PMID: 15590756.

View in: PubMed Mentions: 7 Fields:
Nep Nephrology
Translation:Animals Cells
Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E125-32. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC. PMID: 15367398.

View in: PubMed Mentions: 201 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1. Hypertension. 2004 Sep; 44(3):283-8. Rahmutula D, Cui J, Chen S, Gardner DG. PMID: 15262909.

View in: PubMed Mentions: 3 Fields:
Vas Vascular Diseases
Translation:Animals Cells
Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells. Hypertension. 2004 Apr; 43(4):866-71. Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG. PMID: 15007040.

View in: PubMed Mentions: 8 Fields:
Vas Vascular Diseases
Translation:Animals Cells
Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J Biol Chem. 2004 Apr 02; 279(14):13755-63. Chen S, Gardner DG. PMID: 14742443.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Animals Cells
Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene. J Biol Chem. 2004 Mar 05; 279(10):9287-97. Anderson HD, Wang F, Gardner DG. PMID: 14645255.

View in: PubMed Mentions: 11 Fields:
Bio Biochemistry
Translation:Animals Cells
Natriuretic peptides: markers or modulators of cardiac hypertrophy? Trends Endocrinol Metab. 2003 Nov; 14(9):411-6. Gardner DG. PMID: 14580760.

View in: PubMed Mentions: 47 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem. 2004 Jan 09; 279(2):963-9. Anderson HD, Rahmutula D, Gardner DG. PMID: 14581470.

View in: PubMed Mentions: 64 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Endocrinology. 2003 Sep; 144(9):4187-94. Liang F, Wang F, Zhang S, Gardner DG. PMID: 12933694.

View in: PubMed Mentions: 25 Fields:
End Endocrinology
Translation:Animals Cells
Brain natriuretic peptide: a marker for subclinical cardiovascular disease? Am J Med. 2003 Mar; 114(4):329-30. Gardner DG. PMID: 12681464.

View in: PubMed Mentions: Fields:
Med Medicine (General)
Translation:Humans
Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003 Feb 21; 92(3):300-7. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. PMID: 12595342.

View in: PubMed Mentions: 47 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals Cells
Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes. J Biol Chem. 2003 Apr 25; 278(17):15073-83. Liang F, Webb P, Marimuthu A, Zhang S, Gardner DG. PMID: 12562779.

View in: PubMed Mentions: 21 Fields:
Bio Biochemistry
Translation:Animals Cells
Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Hypertension. 2003 Mar; 41(3 Pt 2):675-81. Ye Q, Chen S, Gardner DG. PMID: 12623978.

View in: PubMed Mentions: 12 Fields:
Vas Vascular Diseases
Translation:Animals Cells
Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. J Biol Chem. 2002 Sep 06; 277(36):32498-504. Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG. PMID: 12082097.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry
Translation:Animals Cells
Thyroid hormone export varies among primary cells and appears to differ from hormone uptake. Endocrinology. 2002 Feb; 143(2):476-83. Neves FA, Cavalieri RR, Simeoni LA, Gardner DG, Baxter JD, Scharschmidt BF, Lomri N, Ribeiro RC. PMID: 11796501.

View in: PubMed Mentions: 3 Fields:
End Endocrinology
Translation:Humans Animals Cells
Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes. Cell Mol Biol Lett. 2002; 7(2):323-9. Kovacic-Milivojevic B, Damsky CC, Gardner DG, Ilic D. PMID: 12097978.

View in: PubMed Mentions: 5 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Animals Cells
Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK. J Biol Chem. 2002 Feb 22; 277(8):6037-43. Chen S, Gardner DG. PMID: 11744737.

View in: PubMed Mentions: 8 Fields:
Bio Biochemistry
Translation:Animals Cells
Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells 1. Endocrinology. 1999 Apr 1; 140(4):1695-1701. Liang LF, Schaufele SF, Gardner GD. .

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Natriuretic Peptides and the Heart. Hormones and the Heart in Health and Disease. 1999 Jan 1; 1-20. Gardner GD, Kovacic-Milivojevic KB, Liang LF, Chen CS. .

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Cellular and Molecular Aspects of the A-Type Natriuretic Peptide. Natriuretic Peptides in Health and Disease. 1997 Jan 1; 71-94. Gardner GD, Wu WJ, Kovacic-Milivojevic KB. .

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Divergent Regulation of the Human Atrial Natriuretic Peptide Gene by c-jun and c-fos. Molecular and Cellular Biology. 1992 Jan 1; 12(1):292-301. Kovacic-Milivojevic KB, Gardner GD. .

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Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos. Molecular and Cellular Biology. 1992 Jan 1; 12(1):292-301. Kovacic-Milivojevic KB, Gardner GD. .

View in: Publisher Site Mentions:
42 Extravascular shift of fluid and albumin induced by endothelin in binephrectomized rats. Journal of Hypertension. 1991 Sep 1; 9(9):885. Valentin VJ, Gardner GD, Ribstein RJ, Mimran MA, Humphreys HM. .

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Atrial Natriuretic Peptide. Nature Biotechnology. 1988 May 1; 6(5):529-546. Baxter BJ, Lewicki LJ, Gardner GD. .

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THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION11This work was supported by NIH Grants AM19997 and AM18878 and NSF Grant 8004735. Gene Regulation. 1982 Jan 1; 235-251. Eberhardt EN, Selby SM, Cathala CG, Karin KM, Gutierrez-Hartmann GA, Mellon MS, Lan LN, Gardner GD, Baxter BJ. .

View in: Publisher Site Mentions: