Yoshikazu Uchida, PhD

Title(s)Full Professional Researcher, Dermatology
SchoolSchool of Medicine
Address3333 California Street, #485
San Francisco CA 94118
Phone415-575-0524
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    University of California, San FranciscoPostdoctoral StudiesGraduate Division

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sphingosine-1-phosphate-cathelicidin axis plays a pivotal role in the development of cutaneous squamous cell carcinoma. J Invest Dermatol. 2024 Aug 30. Park K, Shin KO, Kim YI, Nielsen-Scott AL, Mainzer C, Celli A, Bae Y, Chae S, Ann H, Choi Y, Park JH, Park SH, Hwang JT, Kang SG, Wakefield JS, Arron ST, Holleran WM, Mauro TM, Elias PM, Uchida Y. PMID: 39218144.
      View in: PubMed   Mentions:    Fields:    
    2. Diesel Particulate Matter Permeation into Normal Human Skin and Intervention Using a Topical Ceramide Formulation. Skin Pharmacol Physiol. 2024 May 22; 1-8. Shin KO, Ishida K, Mihara H, Choi Y, Park JH, Park SH, Hwang JT, Wakefield JS, Obata Y, Uchida Y, Park K. PMID: 38768569.
      View in: PubMed   Mentions:    Fields:    
    3. Barrier Abnormalities in Type 1 Diabetes Mellitus: The Roles of Inflammation and Ceramide Metabolism. J Invest Dermatol. 2024 Apr; 144(4):802-810.e5. Shin KO, Kim B, Choi Y, Bae YJ, Park JH, Park SH, Hwang JT, Choi EH, Uchida Y, Park K. PMID: 37952608.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Modulation of Aryl Hydrocarbon Receptor Can Be a Strategy to Improve Epidermal Barrier Function by Increasing Glucosylceramide Synthesis. J Invest Dermatol. 2023 10; 143(10):1862-1864. Park K, Uchida Y. PMID: 37436335.
      View in: PubMed   Mentions:    Fields:    
    5. The Epidermal Environment's Influence on the Dermal Environment in Response to External Stress. Skin Pharmacol Physiol. 2023; 36(3):149-159. Yoshida M, Shin KO, Muraoka S, Choi Y, Park JH, Park SH, Hwang JT, Park K, Uchida Y. PMID: 36927667.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Exogenous Ceramide Serves as a Precursor to Endogenous Ceramide Synthesis and as a Modulator of Keratinocyte Differentiation. Cells. 2022 05 25; 11(11). Shin KO, Mihara H, Ishida K, Uchida Y, Park K. PMID: 35681438; PMCID: PMC9179460.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Euphorbia supina Extracts Block NADPH Oxidase-Mediated, Ceramide-Induced Apoptosis Initiated by Diesel Particulate Matter. Pharmaceuticals (Basel). 2022 Mar 31; 15(4). Shin KO, Kim S, Kim B, Park HY, Jung E, Kim G, Kim D, Cho HE, Uchida Y, Park K. PMID: 35455428; PMCID: PMC9026628.
      View in: PubMed   Mentions:
    8. Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway. Int J Mol Sci. 2022 Feb 28; 23(5). Shin KO, Uchida Y, Park K. PMID: 35269833; PMCID: PMC8910364.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    9. N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation. Int J Mol Sci. 2021 Aug 02; 22(15). Shin KO, Kim S, Park BD, Uchida Y, Park K. PMID: 34361066; PMCID: PMC8348051.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    10. Ceramides in Skin Health and Disease: An Update. Am J Clin Dermatol. 2021 Nov; 22(6):853-866. Uchida Y, Park K. PMID: 34283373.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    11. Phenotypic overlap between atopic dermatitis and autism. BMC Neurosci. 2021 06 22; 22(1):43. Shin KO, Crumrine DA, Kim S, Lee Y, Kim B, Abuabara K, Park C, Uchida Y, Wakefield JS, Meyer JM, Jeong S, Park BD, Park K, Elias PM. PMID: 34157971; PMCID: PMC8218496.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    12. [Pathogenic and Compensatory Mechanisms in Epidermis of Sphingomyelin Synthase 2-Deficient Mice]. Skin Pharmacol Physiol. 2021; 34(5):246-252. Sakai S, Makino A, Nishi A, Ichikawa T, Yamashita T, Taniguchi M, Tokudome Y, Hirabayashi Y, Akiyama M, Crumrine D, Uchida Y, Elias PM, Tsuchida T, Hamanaka S. PMID: 33915532; PMCID: PMC8410625.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Cathelicidin-Related Antimicrobial Peptide Regulates CD73 Expression in Mouse Th17 Cells via p38. Cells. 2020 06 26; 9(6). Lee J, Shin KO, Kim Y, Cho J, Lim HW, Yoon SI, Lee GS, Ko HJ, Kim PH, Uchida Y, Park K, Kang SG. PMID: 32604872; PMCID: PMC7348842.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. A Method to Investigate the Epidermal Permeability Barrier In Vitro. Methods Mol Biol. 2020; 2154:73-90. Uchida Y, Celli A. PMID: 32314209.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology. Exp Dermatol. 2020 03; 29(3):312-321. Ramot Y, Bertolini M, Boboljova M, Uchida Y, Paus R. PMID: 31769892.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Tissue microenvironment initiates an immune response to structural components of Staphylococcus aureus. Exp Dermatol. 2019 02; 28(2):161-168. Mainzer C, Packard T, Bordes S, Closs B, Greene WC, Elias PM, Uchida Y. PMID: 30566255; PMCID: PMC6706075.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Insights into the role of endoplasmic reticulum stress in skin function and associated diseases. FEBS J. 2019 01; 286(2):413-425. Park K, Lee SE, Shin KO, Uchida Y. PMID: 30586218; PMCID: PMC6362265.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    18. Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope. J Invest Dermatol. 2019 04; 139(4):760-768. Crumrine D, Khnykin D, Krieg P, Man MQ, Celli A, Mauro TM, Wakefield JS, Menon G, Mauldin E, Miner JH, Lin MH, Brash AR, Sprecher E, Radner FPW, Choate K, Roop D, Uchida Y, Gruber R, Schmuth M, Elias PM. PMID: 30471252; PMCID: PMC11249047.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    19. Both Sphingosine Kinase 1 and 2 Coordinately Regulate Cathelicidin Antimicrobial Peptide Production during Keratinocyte Differentiation. J Invest Dermatol. 2019 02; 139(2):492-494. Shin KO, Kim KP, Cho Y, Kang MK, Kang YH, Lee YM, Ikushiro H, Yokota M, Yano T, Choe SJ, Choi EH, Lim CJ, Park K, Holleran WM, Park K, Uchida Y. PMID: 30227139; PMCID: PMC6342641.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism. J Med Food. 2018 Nov; 21(11):1129-1136. Shin KO, Choe SJ, Uchida Y, Kim I, Jeong Y, Park K. PMID: 30148701; PMCID: PMC6913107.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    21. Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production. J Med Food. 2018 Jul; 21(7):701-708. Nakamura T, Yamamura H, Park K, Pereira C, Uchida Y, Horie N, Kim M, Itami S. PMID: 29583066.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines. Am J Pathol. 2018 06; 188(6):1419-1429. Mauldin EA, Crumrine D, Casal ML, Jeong S, Opálka L, Vavrova K, Uchida Y, Park K, Craiglow B, Choate KA, Shin KO, Lee YM, Grove GL, Wakefield JS, Khnykin D, Elias PM. PMID: 29548991; PMCID: PMC5971224.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    23. Topical 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Corrects Cutaneous Features of Systemic Glucocorticoid Excess in Female Mice. Endocrinology. 2018 01 01; 159(1):547-556. Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM. PMID: 29087473; PMCID: PMC6459061.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis. Biomol Ther (Seoul). 2017 Sep 01; 25(5):511-518. Lim CJ, Lee YM, Kang SG, Lim HW, Shin KO, Jeong SK, Huh YH, Choi S, Kor M, Seo HS, Park BD, Park K, Ahn JK, Uchida Y, Park K. PMID: 28822991; PMCID: PMC5590795.
      View in: PubMed   Mentions: 18  
    25. Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation. Stem Cells. 2017 08; 35(8):2001-2007. Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R. PMID: 28600817.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    26. [Roles of ceramide and its metabolites in cutaneous tissues]. Seikagaku. 2017 Apr; 89(2):164-75. Uchida Y. PMID: 29624978.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    27. ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1334-42. Park K, Ikushiro H, Seo HS, Shin KO, Kim YI, Kim JY, Lee YM, Yano T, Holleran WM, Elias P, Uchida Y. PMID: 26903652; PMCID: PMC4791017.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    28. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. J Dermatol Sci. 2015 Sep; 79(3):229-34. Jeong SK, Kim YI, Shin KO, Kim BW, Lee SH, Jeon JE, Kim HJ, Lee YM, Mauro TM, Elias PM, Uchida Y, Park K. PMID: 26113114; PMCID: PMC4624019.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    29. UVB induces epidermal 11β-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. PMID: 25739654; PMCID: PMC6365099.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. Lowered humidity produces human epidermal equivalents with enhanced barrier properties. Tissue Eng Part C Methods. 2015 Jan; 21(1):15-22. Sun R, Celli A, Crumrine D, Hupe M, Adame LC, Pennypacker SD, Park K, Uchida Y, Feingold KR, Elias PM, Ilic D, Mauro TM. PMID: 24803151; PMCID: PMC4291214.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    31. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol. 2014 Dec; 34(24):4368-78. Kim YI, Park K, Kim JY, Seo HS, Shin KO, Lee YM, Holleran WM, Elias PM, Uchida Y. PMID: 25312644; PMCID: PMC4248733.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    32. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. J Nutr Biochem. 2014 Jul; 25(7):734-40. Park K, Kim YI, Shin KO, Seo HS, Kim JY, Mann T, Oda Y, Lee YM, Holleran WM, Elias PM, Uchida Y. PMID: 24768661; PMCID: PMC4441818.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Increased glucocorticoid activation during mouse skin wound healing. J Endocrinol. 2014 Apr; 221(1):51-61. Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM. PMID: 24464022.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    34. Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation. Int J Mol Med. 2014 Jan; 33(1):178-84. Park K, Ju WC, Yeo JH, Kim JY, Seo HS, Uchida Y, Cho Y. PMID: 24248634.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. Formation and functions of the corneocyte lipid envelope (CLE). Biochim Biophys Acta. 2014 Mar; 1841(3):314-8. Elias PM, Gruber R, Crumrine D, Menon G, Williams ML, Wakefield JS, Holleran WM, Uchida Y. PMID: 24076475; PMCID: PMC3943821.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    36. Ceramide signaling in mammalian epidermis. Biochim Biophys Acta. 2014 Mar; 1841(3):453-62. Uchida Y. PMID: 24055887; PMCID: PMC3943494.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    37. Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis. J Dermatol Sci. 2013 Dec; 72(3):296-303. Loiseau N, Obata Y, Moradian S, Sano H, Yoshino S, Aburai K, Takayama K, Sakamoto K, Holleran WM, Elias PM, Uchida Y. PMID: 24070864; PMCID: PMC3866955.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    38. Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen. 2013 Sep-Oct; 21(5):715-22. Youm JK, Park K, Uchida Y, Chan A, Mauro TM, Holleran WM, Elias PM. PMID: 23927023; PMCID: PMC4507432.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    39. Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. J Invest Dermatol. 2013 Aug; 133(8):1942-9. Park K, Elias PM, Hupe M, Borkowski AW, Gallo RL, Shin KO, Lee YM, Holleran WM, Uchida Y. PMID: 23856934; PMCID: PMC3753186.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    40. Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles. J Invest Dermatol. 2013 Aug; 133(8):2031-40. Borkowski AW, Park K, Uchida Y, Gallo RL. PMID: 23353987; PMCID: PMC3686920.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    41. Ceramides stimulate caspase-14 expression in human keratinocytes. Exp Dermatol. 2013 Feb; 22(2):113-8. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. PMID: 23362869; PMCID: PMC4099380.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    42. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol. 2013 Feb; 33(4):752-62. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. PMID: 23230267; PMCID: PMC3571353.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    43. Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin. PLoS One. 2012; 7(11):e49519. Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M. PMID: 23166695; PMCID: PMC3499467.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    44. Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation. Exp Dermatol. 2012 Sep; 21(9):688-93. Roelandt T, Heughebaert C, Bredif S, Giddelo C, Baudouin C, Msika P, Roseeuw D, Uchida Y, Elias PM, Hachem JP. PMID: 22897575.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    45. Cellular changes that accompany shedding of human corneocytes. J Invest Dermatol. 2012 Oct; 132(10):2430-2439. Lin TK, Crumrine D, Ackerman LD, Santiago JL, Roelandt T, Uchida Y, Hupe M, Fabriàs G, Abad JL, Rice RH, Elias PM. PMID: 22739796; PMCID: PMC3447115.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    46. GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier. J Invest Dermatol. 2012 Aug; 132(8):2019-25. Tarutani M, Nakajima K, Uchida Y, Takaishi M, Goto-Inoue N, Ikawa M, Setou M, Kinoshita T, Elias PM, Sano S, Maeda Y. PMID: 22572823.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. PMID: 22277942; PMCID: PMC3305850.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    48. Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway. J Biol Chem. 2011 Sep 30; 286(39):34121-30. Park K, Elias PM, Oda Y, Mackenzie D, Mauro T, Holleran WM, Uchida Y. PMID: 21832078; PMCID: PMC3190812.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    49. Altered lipid profiles in the stratum corneum of Sjögren-Larsson syndrome. J Dermatol Sci. 2011 Jul; 63(1):64-6. Nakajima K, Sano S, Uchida Y, Akiyama M, Morita Y, Shimizu H. PMID: 21531120.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    50. The role of fatty acid elongation in epidermal structure and function. Dermatoendocrinol. 2011 Apr; 3(2):65-9. Uchida Y. PMID: 21695014; PMCID: PMC3117004.
      View in: PubMed   Mentions: 13  
    51. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. PMID: 21220706; PMCID: PMC3322545.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    52. Physicochemical analysis of liposome membranes consisting of model lipids in the stratum corneum. J Oleo Sci. 2011; 60(4):197-202. Aburai K, Yoshino S, Sakai K, Sakai H, Abe M, Loiseau N, Holleran W, Uchida Y, Sakamoto K. PMID: 21427516.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    53. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010 Oct; 130(10):2472-80. Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM. PMID: 20520628.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    54. Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome. J Invest Dermatol. 2010 Oct; 130(10):2497-9. Uchida Y, Cho Y, Moradian S, Kim J, Nakajima K, Crumrine D, Park K, Ujihara M, Akiyama M, Shimizu H, Holleran WM, Sano S, Elias PM. PMID: 20520629.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    55. Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest. 2010 Mar; 120(3):871-82. Bonnart C, Deraison C, Lacroix M, Uchida Y, Besson C, Robin A, Briot A, Gonthier M, Lamant L, Dubus P, Monsarrat B, Hovnanian A. PMID: 20179351; PMCID: PMC2827963.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    56. Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome. J Dermatol Sci. 2010 Feb; 57(2):102-7. Ujihara M, Nakajima K, Yamamoto M, Teraishi M, Uchida Y, Akiyama M, Shimizu H, Sano S. PMID: 20022472.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    57. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. J Allergy Clin Immunol. 2010 Jan; 125(1):160-9.e1-5. Hatano Y, Man MQ, Uchida Y, Crumrine D, Mauro TM, Feingold KR, Elias PM, Holleran WM. PMID: 19818482; PMCID: PMC2859962.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    58. Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes. J Biol Chem. 2009 Jul 10; 284(28):18942-52. Jiang YJ, Uchida Y, Lu B, Kim P, Mao C, Akiyama M, Elias PM, Holleran WM, Grunfeld C, Feingold KR. PMID: 19429679; PMCID: PMC2707228.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    59. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J Invest Dermatol. 2009 Jul; 129(7):1824-35. Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM. PMID: 19177139; PMCID: PMC2695850.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    60. Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. J Invest Dermatol. 2009 Jun; 129(6):1367-78. Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD. PMID: 19052561; PMCID: PMC2843519.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    61. Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis. Am J Pathol. 2008 Sep; 173(3):689-99. Elias PM, Arbiser J, Brown BE, Rossiter H, Man MQ, Cerimele F, Crumrine D, Gunathilake R, Choi EH, Uchida Y, Tschachler E, Feingold KR. PMID: 18688025; PMCID: PMC2527083.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    62. Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation. J Biol Chem. 2008 Jun 13; 283(24):16682-92. Charruyer A, Bell SM, Kawano M, Douangpanya S, Yen TY, Macher BA, Kumagai K, Hanada K, Holleran WM, Uchida Y. PMID: 18411267; PMCID: PMC2423244.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    63. On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides. J Dermatol Sci. 2008 Jul; 51(1):37-43. Uchida Y, Holleran WM, Elias PM. PMID: 18396015; PMCID: PMC2410086.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    64. Omega-O-acylceramide, a lipid essential for mammalian survival. J Dermatol Sci. 2008 Aug; 51(2):77-87. Uchida Y, Holleran WM. PMID: 18329855.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    65. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol. 2008 Jan; 128(1):79-86. Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, Elias PM. PMID: 17671515; PMCID: PMC2671229.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    66. Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation. J Biol Chem. 2007 May 04; 282(18):13211-9. Uchida Y, Hama H, Alderson NL, Douangpanya S, Wang Y, Crumrine DA, Elias PM, Holleran WM. PMID: 17355976.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCellsCTClinical Trials
    67. Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Hum Mol Genet. 2007 Mar 01; 16(5):471-82. Vasireddy V, Uchida Y, Salem N, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R. PMID: 17208947; PMCID: PMC1839956.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    68. Epidermal sphingolipids: metabolism, function, and roles in skin disorders. FEBS Lett. 2006 Oct 09; 580(23):5456-66. Holleran WM, Takagi Y, Uchida Y. PMID: 16962101.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    69. Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol. 2006 Sep; 126(9):2074-86. Hachem JP, Houben E, Crumrine D, Man MQ, Schurer N, Roelandt T, Choi EH, Uchida Y, Brown BE, Feingold KR, Elias PM. PMID: 16691196.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    70. Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J Lipid Res. 2006 May; 47(5):1063-70. Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y. PMID: 16477081.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    71. Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. J Invest Dermatol. 2006 Feb; 126(2):386-92. Man MQ, Choi EH, Schmuth M, Crumrine D, Uchida Y, Elias PM, Holleran WM, Feingold KR. PMID: 16374473.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    72. Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity. Arch Dermatol Res. 2005 Sep; 297(3):127-33. Rice RH, Crumrine D, Uchida Y, Gruber R, Elias PM. PMID: 16133457.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    73. Activation of CYP1A1 gene expression during primary culture of mouse hepatocytes. Toxicology. 2005 Dec 15; 216(2-3):224-31. Tamaki H, Sakuma T, Uchida Y, Jaruchotikamol A, Nemoto N. PMID: 16169145.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    74. Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol. 2005 Sep; 125(3):510-20. Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE, Rogiers V, Roseeuw D, Feingold KR, Elias PM. PMID: 16117792.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    75. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science. 2005 Apr 15; 308(5720):411-3. Ting SB, Caddy J, Hislop N, Wilanowski T, Auden A, Zhao LL, Ellis S, Kaur P, Uchida Y, Holleran WM, Elias PM, Cunningham JM, Jane SM. PMID: 15831758.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    76. Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features. J Invest Dermatol. 2004 Sep; 123(3):464-9. Hara-Chikuma M, Takeda J, Tarutani M, Uchida Y, Holleran WM, Endo Y, Elias PM, Inoue S. PMID: 15304084.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    77. Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells. Cancer Res. 2004 Sep 01; 64(17):6271-9. Uchida Y, Itoh M, Taguchi Y, Yamaoka S, Umehara H, Ichikawa S, Hirabayashi Y, Holleran WM, Okazaki T. PMID: 15342415.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    78. Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis). J Invest Dermatol. 2004 Apr; 122(4):909-22. Schmuth M, Fluhr JW, Crumrine DC, Uchida Y, Hachem JP, Behne M, Moskowitz DG, Christiano AM, Feingold KR, Elias PM. PMID: 15102081.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    79. Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol. 2004 Apr; 122(4):971-83. Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P, Willson TM, Elias PM, Feingold KR. PMID: 15102088.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    80. De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes. J Invest Dermatol. 2003 Apr; 120(4):662-9. Uchida Y, Nardo AD, Collins V, Elias PM, Holleran WM. PMID: 12648232.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    81. Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis. J Clin Invest. 2002 Nov; 110(9):1301-8. Bejaoui K, Uchida Y, Yasuda S, Ho M, Nishijima M, Brown RH, Holleran WM, Hanada K. PMID: 12417569; PMCID: PMC151618.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    82. Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. J Invest Dermatol. 2002 Aug; 119(2):416-23. Hamanaka S, Hara M, Nishio H, Otsuka F, Suzuki A, Uchida Y. PMID: 12190865.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    83. Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress. J Lipid Res. 2002 Aug; 43(8):1293-302. Uchida Y, Murata S, Schmuth M, Behne MJ, Lee JD, Ichikawa S, Elias PM, Hirabayashi Y, Holleran WM. PMID: 12177173.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    84. Basis for the permeability barrier abnormality in lamellar ichthyosis. Exp Dermatol. 2002 Jun; 11(3):248-56. Elias PM, Schmuth M, Uchida Y, Rice RH, Behne M, Crumrine D, Feingold KR, Holleran WM, Pharm D. PMID: 12102664.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
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