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Fred Schaufele, PhD

TitleFull Adjunct Professor
InstitutionUniversity of California San Francisco
DepartmentOb/Gyn, Reproductive Sciences
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-7086
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    Collapse Research 
    Collapse Research Activities and Funding
    UCSF High Throughput Microscope
    NIH/NCRR S10RR023759Jun 10, 2007 - Jun 9, 2008
    Role: Principal Investigator
    Insulin/TZD regulation of protein structure in fat cells
    NIH/NIDDK R21DK062782Mar 1, 2003 - Feb 28, 2005
    Role: Principal Investigator
    Diabetes Research Center
    NIH/NIDDK P30DK063720Sep 1, 2002 - Mar 31, 2020
    Role: Co-Investigator
    Transcription factor interactions at the GH promoter
    NIH/NIDDK R01DK054345Jul 1, 1999 - Aug 28, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Bailey K, Yazdi T, Masharani U, Tyrrell B, Butch A, Schaufele F. Advantages and Limitations of Androgen Receptor-Based Methods for Detecting Anabolic Androgenic Steroid Abuse as Performance Enhancing Drugs. PLoS One. 2016; 11(3):e0151860. PMID: 26998755; PMCID: PMC4801337.
    2. Schaufele F. Studying Nuclear Receptor Complexes in the Cellular Environment. Methods Mol Biol. 2016; 1443:79-104. PMID: 27246335.
      View in: PubMed
    3. Fujinaga K, Luo Z, Schaufele F, Peterlin BM. Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells. J Biol Chem. 2015 Jan 16; 290(3):1829-36. PMID: 25492871; PMCID: PMC4340424.
    4. Catalano KJ, Maddux BA, Szary J, Youngren JF, Goldfine ID, Schaufele F. Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain. PLoS One. 2014; 9(9):e108693. PMID: 25259572; PMCID: PMC4178179.
    5. Schaufele F. Maximizing the quantitative accuracy and reproducibility of Förster resonance energy transfer measurement for screening by high throughput widefield microscopy. Methods. 2014 Mar 15; 66(2):188-99. PMID: 23927839; PMCID: PMC3916941.
    6. Krylova I, Kumar RR, Kofoed EM, Schaufele F. A versatile, bar-coded nuclear marker/reporter for live cell fluorescent and multiplexed high content imaging. PLoS One. 2013; 8(5):e63286. PMID: 23691010; PMCID: PMC3653935.
    7. Schaufele F. FRET analysis of androgen receptor structure and biochemistry in living cells. Methods Mol Biol. 2011; 776:147-66. PMID: 21796526.
      View in: PubMed
    8. Kofoed EM, Guerbadot M, Schaufele F. Structure, affinity, and availability of estrogen receptor complexes in the cellular environment. J Biol Chem. 2010 Jan 22; 285(4):2428-37. PMID: 19926790; PMCID: PMC2807300.
    9. Paruthiyil S, Cvoro A, Zhao X, Wu Z, Sui Y, Staub RE, Baggett S, Herber CB, Griffin C, Tagliaferri M, Harris HA, Cohen I, Bjeldanes LF, Speed TP, Schaufele F, Leitman DC. Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS One. 2009 Jul 17; 4(7):e6271. PMID: 19609440; PMCID: PMC2707612.
    10. Kofoed EM, Guerbadot M, Schaufele F. Dimerization between aequorea fluorescent proteins does not affect interaction between tagged estrogen receptors in living cells. J Biomed Opt. 2008 May-Jun; 13(3):031207. PMID: 18601531; PMCID: PMC2581880.
    11. Day RN, Schaufele F. Fluorescent protein tools for studying protein dynamics in living cells: a review. J Biomed Opt. 2008 May-Jun; 13(3):031202. PMID: 18601526.
      View in: PubMed
    12. Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S. A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci. 2008 Feb 15; 121(Pt 4):437-49. PMID: 18230651.
      View in: PubMed
    13. Liu X, Wu B, Szary J, Kofoed EM, Schaufele F. Functional sequestration of transcription factor activity by repetitive DNA. J Biol Chem. 2007 Jul 20; 282(29):20868-76. PMID: 17526489; PMCID: PMC3812952.
    14. Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007 Feb; 148(2):538-47. PMID: 17095596.
      View in: PubMed
    15. Padron A, Li L, Kofoed EM, Schaufele F. Ligand-selective interdomain conformations of estrogen receptor-alpha. Mol Endocrinol. 2007 Jan; 21(1):49-61. PMID: 17008385.
      View in: PubMed
    16. Schaufele F, Carbonell X, Guerbadot M, Borngraeber S, Chapman MS, Ma AA, Miner JN, Diamond MI. The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9802-7. PMID: 15994236; PMCID: PMC1168953.
    17. Day RN, Schaufele F. Imaging molecular interactions in living cells. Mol Endocrinol. 2005 Jul; 19(7):1675-86. PMID: 15761028; PMCID: PMC2900770.
    18. Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA. Phosphorylation of C/EBPalpha inhibits granulopoiesis. Mol Cell Biol. 2004 Jan; 24(2):675-86. PMID: 14701740; PMCID: PMC343788.
    19. Enwright JF, Kawecki-Crook MA, Voss TC, Schaufele F, Day RN. A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription. Mol Endocrinol. 2003 Feb; 17(2):209-22. PMID: 12554749; PMCID: PMC2900764.
    20. Schaufele F, Wang X, Liu X, Day RN. Conformation of CCAAT/enhancer-binding protein alpha dimers varies with intranuclear location in living cells. J Biol Chem. 2003 Mar 21; 278(12):10578-87. PMID: 12531886.
      View in: PubMed
    21. Day RN, Voss TC, Enwright JF, Booker CF, Periasamy A, Schaufele F. Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus. Mol Endocrinol. 2003 Mar; 17(3):333-45. PMID: 12554785; PMCID: PMC2910340.
    22. Liu W, Enwright JF, Hyun W, Day RN, Schaufele F. CCAAT/enhancer binding protein alpha uses distinct domains to prolong pituitary cells in the growth 1 and DNA synthesis phases of the cell cycle. BMC Cell Biol. 2002 Mar 21; 3:6. PMID: 11914124; PMCID: PMC101385.
    23. Day RN, Periasamy A, Schaufele F. Fluorescence resonance energy transfer microscopy of localized protein interactions in the living cell nucleus. Methods. 2001 Sep; 25(1):4-18. PMID: 11558993.
      View in: PubMed
    24. Schaufele F. Shedding light on molecular timing. Nat Biotechnol. 2001 Jan; 19(1):21-2. PMID: 11135545.
      View in: PubMed
    25. Farrow KN, Manning N, Schaufele F, Gutierrez-Hartmann A. The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner. J Biol Chem. 1996 Jul 19; 271(29):17139-46. PMID: 8663380.
      View in: PubMed
    26. Tansey WP, Schaufele F, Heslewood M, Handford C, Reudelhuber TL, Catanzaro DF. Distance-dependent interactions between basal, cyclic AMP, and thyroid hormone response elements in the rat growth hormone promoter. J Biol Chem. 1993 Jul 15; 268(20):14906-11. PMID: 8392063.
      View in: PubMed
    27. Vasserot AP, Schaufele FJ, Birnstiel ML. Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4345-9. PMID: 2734288; PMCID: PMC287265.
    28. Gilmartin GM, Schaufele F, Schaffner G, Birnstiel ML. Functional analysis of the sea urchin U7 small nuclear RNA. Mol Cell Biol. 1988 Mar; 8(3):1076-84. PMID: 2835659; PMCID: PMC363250.
    29. Schaufele F, Birnstiel ML. The inability of the Psammechinus miliaris H3 RNA to be processed in the Xenopus oocyte is associated with sequences distinct from those highly conserved amongst sea urchin histone RNAs. Nucleic Acids Res. 1987 Oct 26; 15(20):8305-17. PMID: 2823227; PMCID: PMC306361.
    30. Schaufele F, Gilmartin GM, Bannwarth W, Birnstiel ML. Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA. Nature. 1986 Oct 30-Nov 5; 323(6091):777-81. PMID: 3022153.
      View in: PubMed