Fred Schaufele, PhD

Title(s)Professor Emeritus, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
AddressRemote Location, #001
Varies 00001
Phone415-476-7086
Emailfred.schaufele@ucsf.edu
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    Collapse Overview 
    Collapse Overview
    The Schaufele laboratory has a long-standing research interest in the mechanisms of action of hormones and their receptors. Emphasis has been on the regulation of global, tissue-specific gene expression patterns by DNA-binding transcription factors, including nuclear receptors, and their co-factors. In the nuclear receptor field, our studies on androgen and estrogen receptors have been oriented towards understanding their basic mechanisms of action and their roles as central regulators of the growth, respectively, of the majority of breast tumors and almost all prostate tumors. This led to the development of high throughput, highly quantitative capabilities for rapidly identifying agents that up- or down-regulate receptor activity.

    We currently are incorporating that experience into a research program designed to identify new classes of pharmaceuticals for the treatment of advanced prostate cancer. The growth of those tumors is strongly driven by abnormal activation of the androgen receptor. Most of those tumors initially respond to currently available androgen receptor-targeted drugs. But the tumors change over time in ways in which the drugs no longer are effective and, when a patient becomes resistant to all available drugs, the tumor unfortunately becomes lethal. Most tumors that develop such drug ‘resistance’ still rely on androgen receptors for their growth. Our research program is oriented towards creating a new class of drugs that blocks a specific variant of the androgen receptor that arises during the development of treatment resistance but that lacks the binding sites for currently available drugs. The aim of these studies is to prolong the success of prostate cancer treatment, hopefully indefinitely.

    Collapse Research 
    Collapse Research Activities and Funding
    AR Splice Variants in Castration Resistant Prostate Cancer
    GlaxoSmithKline Sponsored Reseach Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Nutrition and Obesity Research Center
    NIH/NIDDK P30 DK098722Aug 1, 2015 - Feb 28, 2018
    Role: Director of NORC Cores
    AR Splice Variants in Castration Resistant Prostate Cancer
    Discovery Partnerships with Academia, GlaxoSmithKline Jun 1, 2015 - Nov 30, 2016
    Role: Principal Investigator
    MicroRNAs that Regulate Castration-Resistant Androgen Receptor Activity and Cell Growth
    CDMRP ('DOD') Prostate Cancer Research Program PC131303Oct 1, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Hyperinsulinemia, Insulin Resistance and Structural Alterations within the Insulin Receptor
    Novo Nordisk Diabetes Innovative Award Program Jan 1, 2012 - Dec 31, 2013
    Role: Principal Investigator
    Hyperinsulinemia, Insulin Resistance and Structural Alterations within the Insulin Receptor
    UCSF Diabetes Center Pilot Grant Jul 1, 2011 - Jun 30, 2012
    Role: Principal Investigator
    Detection of novel androgenic anabolic activities in urine and serum with a highly sensitive, cost-efficient Androgen Receptor BioAssay
    Partnership for Clean Competition Oct 1, 2009 - Mar 31, 2012
    Role: Principal Investigator
    High throughput identification and characterization of novel anti-prostate cancer therapeutics
    CDMRP ('DOD') Prostate Cancer Research Program PC080258Apr 1, 2009 - Mar 31, 2012
    Role: Principal Investigator
    High throughput imaging of insulin receptor signaling in living cells
    UCSF Clinical/Translational Methods Catalyst Award Apr 1, 2009 - Jun 30, 2010
    Role: Principal Investigator
    UCSF High Throughput Microscope
    NIH S10RR023759Jun 10, 2007 - Jun 9, 2008
    Role: Principal Investigator
    Novel imaging techniques that compare estrogen receptor structure in tumors and normal tissues of intact living animals
    Susan G. Komen Breast Cancer Foundation BCTR0503890Jun 1, 2005 - May 31, 2007
    Role: Principal Investigator
    Transcription factor compartmentalization and liver-specific gene expression
    UCSF Liver Center Pilot and Feasibility Program Jun 1, 2005 - May 31, 2006
    Role: Principal Investigator
    Temporal and Spatial Dynamics of Androgen Receptor Conformation and Interactions in Prostate Cancer Cells.
    CDMRP ('DOD') Prostate Cancer Research Program PC040777Sep 1, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Insulin/TZD regulation of protein structure in fat cells
    NIH R21DK062782Mar 1, 2003 - Feb 28, 2005
    Role: Principal Investigator
    Diabetes Research Center
    NIH P30DK063720Sep 1, 2002 - Mar 31, 2021
    Role: Co-Investigator
    Structure of factors controlling glucose regulation measured in living cells by Fluorescence Resonance Energy Transfer
    UCSF Diabetes Center Pilot Grant Jan 1, 2002 - Dec 31, 2002
    Role: Principal Investigator
    Novel technologies to identify tissue-selective estrogens
    California Breast Cancer Research Program 71B-024Jul 1, 2001 - Jun 30, 2003
    Role: Principal Investigator
    Dynamic cellular imaging to identify improved anti-estrogens for breast cancer therapy
    The Susan G. Komen Breast Cancer Foundation BCTR 2000 210May 1, 2001 - Apr 30, 2003
    Role: Principal Investigator
    Cellular imaging technologies for discovering improved breast cancer therapies
    CDMRP ('DOD') Breast Cancer Research Program DAMD17-01-1-0190Apr 1, 2001 - Mar 31, 2004
    Role: Principal Investigator
    in vivo estradiol, tamoxifen and raloxifene modulation of association/dissociation kinetics for estrogen receptor, interacting co-factors and DNA binding sites
    CDMRP ('DOD') Breast Cancer Research Program DAMD17-01-1-0498Apr 1, 2001 - Mar 31, 2002
    Role: Principal Investigator
    Transcription factor interactions at the GH promoter
    NIH R01DK054345Jul 1, 1999 - Aug 28, 2009
    Role: Principal Investigator
    Spatiotemporal dynamics of gene regulatory factors in vivo
    International Union Against Cancer/American Cancer Society Jul 1, 1999 - Jun 30, 2000
    Role: Principal Investigator
    Spatiotemporal dynamics of protein interaction cascades in vivo
    UCSF Research Evaluation and Allocation Committee Jul 1, 1999 - Jun 30, 2000
    Role: Principal Investigator
    A transcription factor domain used selectively in synergistic activation
    American Cancer Society RPG 98431-TBEJul 1, 1994 - Jun 30, 2000
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SAT-748 Advantages and Limitations of an Integrative Measurement for All Serum Androgens and Anti-Androgens. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Schaufele SF, Mody MA, Huddleston HH. .
      View in: Publisher Site   Mentions:
    2. SUN-LB138 Dynamic Structural Model of Testosterone Entry Into the Unliganded Androgen Receptor. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1). Krylova KI, Schaufele SF, Guilbert GC. .
      View in: Publisher Site   Mentions:
    3. Advantages and Limitations of Androgen Receptor-Based Methods for Detecting Anabolic Androgenic Steroid Abuse as Performance Enhancing Drugs. PLoS One. 2016; 11(3):e0151860. Bailey K, Yazdi T, Masharani U, Tyrrell B, Butch A, Schaufele F. PMID: 26998755; PMCID: PMC4801337.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    4. Studying Nuclear Receptor Complexes in the Cellular Environment. Methods Mol Biol. 2016; 1443:79-104. Schaufele F. PMID: 27246335.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells. J Biol Chem. 2015 Jan 16; 290(3):1829-36. Fujinaga K, Luo Z, Schaufele F, Peterlin BM. PMID: 25492871; PMCID: PMC4340424.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    6. Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain. PLoS One. 2014; 9(9):e108693. Catalano KJ, Maddux BA, Szary J, Youngren JF, Goldfine ID, Schaufele F. PMID: 25259572; PMCID: PMC4178179.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    7. Maximizing the quantitative accuracy and reproducibility of Förster resonance energy transfer measurement for screening by high throughput widefield microscopy. Methods. 2014 Mar 15; 66(2):188-99. Schaufele F. PMID: 23927839; PMCID: PMC3916941.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. A versatile, bar-coded nuclear marker/reporter for live cell fluorescent and multiplexed high content imaging. PLoS One. 2013; 8(5):e63286. Krylova I, Kumar RR, Kofoed EM, Schaufele F. PMID: 23691010; PMCID: PMC3653935.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    9. FRET analysis of androgen receptor structure and biochemistry in living cells. Methods Mol Biol. 2011; 776:147-66. Schaufele F. PMID: 21796526.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Structure, affinity, and availability of estrogen receptor complexes in the cellular environment. J Biol Chem. 2010 Jan 22; 285(4):2428-37. Kofoed EM, Guerbadot M, Schaufele F. PMID: 19926790; PMCID: PMC2807300.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS One. 2009 Jul 17; 4(7):e6271. Paruthiyil S, Cvoro A, Zhao X, Wu Z, Sui Y, Staub RE, Baggett S, Herber CB, Griffin C, Tagliaferri M, Harris HA, Cohen I, Bjeldanes LF, Speed TP, Schaufele F, Leitman DC. PMID: 19609440; PMCID: PMC2707612.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    12. Fluorescent protein tools for studying protein dynamics in living cells: a review. J Biomed Opt. 2008 May-Jun; 13(3):031202. Day RN, Schaufele F. PMID: 18601526.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    13. Dimerization between aequorea fluorescent proteins does not affect interaction between tagged estrogen receptors in living cells. J Biomed Opt. 2008 May-Jun; 13(3):031207. Kofoed EM, Guerbadot M, Schaufele F. PMID: 18601531; PMCID: PMC2581880.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci. 2008 Feb 15; 121(Pt 4):437-49. Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S. PMID: 18230651.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    15. Functional sequestration of transcription factor activity by repetitive DNA. J Biol Chem. 2007 Jul 20; 282(29):20868-76. Liu X, Wu B, Szary J, Kofoed EM, Schaufele F. PMID: 17526489; PMCID: PMC3812952.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    16. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007 Feb; 148(2):538-47. Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC. PMID: 17095596.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    17. Ligand-selective interdomain conformations of estrogen receptor-alpha. Mol Endocrinol. 2007 Jan; 21(1):49-61. Padron A, Li L, Kofoed EM, Schaufele F. PMID: 17008385.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Analysis of in vivo conformation: full-length estrogen receptor-alpha dimers bound by estradiol, tamoxifen, raloxifene or ICI 182780. The FASEB Journal. 2006 Mar 1; 20(4):a111-a111. Padron PA, Li LL, Schaufele SF. .
      View in: Publisher Site   Mentions:
    19. Molecular imaging of biochemical structure and interactions in live cells, tissues and animals. The FASEB Journal. 2006 Mar 1; 20(4):a111-a111. Schaufele SF, Padron PA, Guerbadot GM. .
      View in: Publisher Site   Mentions:
    20. Pericentromeric concentration of transcription factors by junk DNA. The FASEB Journal. 2006 Mar 1; 20(5):a1343-a1343. Szary SJ, Liu LX, Schaufele SF. .
      View in: Publisher Site   Mentions:
    21. Functional sequestration of transcription factors by junk DNA. The FASEB Journal. 2006 Mar 1; 20(5):a1343-a1343. Liu LX, Wu WB, Szary SJ, Schaufele SF. .
      View in: Publisher Site   Mentions:
    22. The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9802-7. Schaufele F, Carbonell X, Guerbadot M, Borngraeber S, Chapman MS, Ma AA, Miner JN, Diamond MI. PMID: 15994236; PMCID: PMC1168953.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    23. Imaging molecular interactions in living cells. Mol Endocrinol. 2005 Jul; 19(7):1675-86. Day RN, Schaufele F. PMID: 15761028; PMCID: PMC2900770.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    24. 4 FRET Imaging in the Wide-Field Microscope. Molecular Imaging. 2005 Jan 1; (Proc. Natl. Acad. Sci. U.S.A.972000):72-94. Schaufele SF, Demarco DI, Day DR. .
      View in: Publisher Site   Mentions:
    25. Phosphorylation of C/EBPalpha inhibits granulopoiesis. Mol Cell Biol. 2004 Jan; 24(2):675-86. Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA. PMID: 14701740; PMCID: PMC343788.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    26. A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription. Mol Endocrinol. 2003 Feb; 17(2):209-22. Enwright JF, Kawecki-Crook MA, Voss TC, Schaufele F, Day RN. PMID: 12554749; PMCID: PMC2900764.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    27. Conformation of CCAAT/enhancer-binding protein alpha dimers varies with intranuclear location in living cells. J Biol Chem. 2003 Mar 21; 278(12):10578-87. Schaufele F, Wang X, Liu X, Day RN. PMID: 12531886.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus. Mol Endocrinol. 2003 Mar; 17(3):333-45. Day RN, Voss TC, Enwright JF, Booker CF, Periasamy A, Schaufele F. PMID: 12554785; PMCID: PMC2910340.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. Cellular Imaging Technologies for Discovering Improved Breast Cancer Therapies. . 2002 May 1. Schaufele SF. .
      View in: Publisher Site   Mentions:
    30. CCAAT/enhancer binding protein alpha uses distinct domains to prolong pituitary cells in the growth 1 and DNA synthesis phases of the cell cycle. BMC Cell Biol. 2002 Mar 21; 3:6. Liu W, Enwright JF, Hyun W, Day RN, Schaufele F. PMID: 11914124; PMCID: PMC101385.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    31. Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Mol Endocrinol. 2002 Mar; 16(3):487-96. Weatherman RV, Chang CY, Clegg NJ, Carroll DC, Day RN, Baxter JD, McDonnell DP, Scanlan TS, Schaufele F. PMID: 11875107.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    32. CCAAT/Enhancer Binding Protein   Assembles Essential Cooperating Factors in Common Subnuclear Domains. Endocrinology. 2001 Oct 1; 15(10):1665-1676. Schaufele SF. .
      View in: Publisher Site   Mentions:
    33. Fluorescence resonance energy transfer microscopy of localized protein interactions in the living cell nucleus. Methods. 2001 Sep; 25(1):4-18. Day RN, Periasamy A, Schaufele F. PMID: 11558993.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    34. Growth factors signal to steroid receptors through mitogen-activated protein kinase regulation of p160 coactivator activity. J Biol Chem. 2001 Jun 22; 276(25):22177-82. Lopez GN, Turck CW, Schaufele F, Stallcup MR, Kushner PJ. PMID: 11301320.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    35. Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription. J Biol Chem. 2001 Jan 12; 276(2):1516-22. Liang F, Schaufele F, Gardner DG. PMID: 11022037.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    36. Shedding light on molecular timing. Nat Biotechnol. 2001 Jan; 19(1):21-2. Schaufele F. PMID: 11135545.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    37. Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. Mol Endocrinol. 2000 Dec; 14(12):2024-39. Schaufele F, Chang CY, Liu W, Baxter JD, Nordeen SK, Wan Y, Day RN, McDonnell DP. PMID: 11117532.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    38. Regulation of estrogen receptor activation of the prolactin enhancer/promoter by antagonistic activation function-2-interacting proteins. Mol Endocrinol. 1999 Jun; 13(6):935-45. Schaufele F. PMID: 10379892.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. Sp1 dependence of natriuretic peptide receptor A gene transcription in rat aortic smooth muscle cells. Endocrinology. 1999 Apr; 140(4):1695-701. Liang F, Schaufele F, Gardner DG. PMID: 10098505.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    40. Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells*. Endocrinology. 1999 Apr 1; 140(4):1695-1701. Liang LF, Schaufele SF, Gardner GD. .
      View in: Publisher Site   Mentions:
    41. Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies. Recent Prog Horm Res. 1998; 53:351-92; discussion 392-4. Ribeiro RC, Apriletti JW, Wagner RL, West BL, Feng W, Huber R, Kushner PJ, Nilsson S, Scanlan T, Fletterick RJ, Schaufele F, Baxter JD. PMID: 9769715.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    42. Activities in Pit-1 determine whether receptor interacting protein 140 activates or inhibits Pit-1/nuclear receptor transcriptional synergy. Mol Endocrinol. 1997 Aug; 11(9):1332-41. Chuang FM, West BL, Baxter JD, Schaufele F. PMID: 9259323.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. CCAAT/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1-5 cells. J Biol Chem. 1996 Aug 30; 271(35):21484-9. Schaufele F. PMID: 8702932.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    44. An activation function in Pit-1 required selectively for synergistic transcription. J Biol Chem. 1996 Jul 26; 271(30):17733-8. Chang W, Zhou W, Theill LE, Baxter JD, Schaufele F. PMID: 8663468.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner. J Biol Chem. 1996 Jul 19; 271(29):17139-46. Farrow KN, Manning N, Schaufele F, Gutierrez-Hartmann A. PMID: 8663380.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    46. The molecular biology of thyroid hormone action. Ann N Y Acad Sci. 1995 Jun 30; 758:366-89. Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD. PMID: 7625705.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    47. Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein-1 site in pUC. Mol Endocrinol. 1994 Apr; 8(4):405-7. Kushner PJ, Baxter JD, Duncan KG, Lopez GN, Schaufele F, Uht RM, Webb P, West BL. PMID: 8052261.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    48. Distance-dependent interactions between basal, cyclic AMP, and thyroid hormone response elements in the rat growth hormone promoter. J Biol Chem. 1993 Jul 15; 268(20):14906-11. Tansey WP, Schaufele F, Heslewood M, Handford C, Reudelhuber TL, Catanzaro DF. PMID: 8392063.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    49. Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site. Mol Cell Biol. 1993 May; 13(5):3042-9. Lopez G, Schaufele F, Webb P, Holloway JM, Baxter JD, Kushner PJ. PMID: 8474460; PMCID: PMC359696.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    50. Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site. Molecular and Cellular Biology. 1993 May 1; 13(5):3042-3049. Lopez LG, Schaufele SF, Webb WP, Holloway HJ, Baxter BJ, Kushner KP. .
      View in: Publisher Site   Mentions:
    51. Positive and Negative Modulation of Jun Action by Thyroid Hormone Receptor at a Unique AP1 Site. Molecular and Cellular Biology. 1993 May 1; 13(5):3042-3049. Lopez LG, Schaufele SF, Webb WP, Holloway HJ, Baxter BJ, Kushner KP. .
      View in: Publisher Site   Mentions:
    52. Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor. Endocrinology. 1992 Apr 1; 6(4):656-665. Schaufele SF. .
      View in: Publisher Site   Mentions:
    53. Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor. Mol Endocrinol. 1992 Apr; 6(4):656-65. Schaufele F, West BL, Baxter JD. PMID: 1584227.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    54. Diagonal Gel Mobility-Shift Assays for the Resolution of Multi-Subunit Complexes Binding to Regulatory Elements of Specific Genes. A Laboratory Guide to In Vitro Studies of Protein-DNA Interactions. 1991 Jan 1; 195-206. Schaufele SF, West WB, Jost JJ, Reudelhuber RT. .
      View in: Publisher Site   Mentions:
    55. Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding. J Biol Chem. 1990 Oct 05; 265(28):17189-96. Schaufele F, West BL, Reudelhuber TL. PMID: 2211620.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    56. Somatotroph- and lactotroph-specific interactions with the homeobox protein binding sites in the rat growth hormone gene promoter. Nucleic Acids Res. 1990 Sep 11; 18(17):5235-43. Schaufele F, West BL, Reudelhuber T. PMID: 1976240; PMCID: PMC332147.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    57. Resolution by diagonal gel mobility shift assays of multisubunit complexes binding to a functionally important element of the rat growth hormone gene promoter. J Biol Chem. 1990 Aug 25; 265(24):14592-8. Schaufele F, Cassill JA, West BL, Reudelhuber T. PMID: 2387870.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    58. Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4345-9. Vasserot AP, Schaufele FJ, Birnstiel ML. PMID: 2734288; PMCID: PMC287265.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    59. Functional analysis of the sea urchin U7 small nuclear RNA. Mol Cell Biol. 1988 Mar; 8(3):1076-84. Gilmartin GM, Schaufele F, Schaffner G, Birnstiel ML. PMID: 2835659; PMCID: PMC363250.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    60. The inability of the Psammechinus miliaris H3 RNA to be processed in the Xenopus oocyte is associated with sequences distinct from those highly conserved amongst sea urchin histone RNAs. Nucleic Acids Res. 1987 Oct 26; 15(20):8305-17. Schaufele F, Birnstiel ML. PMID: 2823227; PMCID: PMC306361.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    61. Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA. Nature. 1986 Oct 30-Nov 5; 323(6091):777-81. Schaufele F, Gilmartin GM, Bannwarth W, Birnstiel ML. PMID: 3022153.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells