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    Julius Guccione, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentSurgery
    Address1657 Scott Str., MZ Bldg E
    San Francisco CA 94115
    Phone415-680-6285
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      University of California, San Diego, CA1985 - 1990Institutional National Research Service Award
      Johns Hopkins University, Baltimore, MD1990 - 1991Institutional National Research Service Award
      1991 - 1993Individual National Research Service Award of the NIH
      1999Richard Skalak Best Paper Award of the ASME Bioengineering Division

      Collapse Overview 
      Collapse Overview
      Julius M. Guccione, Ph.D. is Professor in Residence in the UCSF Department of Surgery, specializing in realistic simulation of the efficacy of novel surgical procedures and devices for treating ischemic cardiomyopathy. He is the sole PI on an active R01 (HL077921: Virtual Tools for Cardiac Ventricular Remodeling Surgery). He is the contact PI on another active R01 (HL118627: Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure). Additionally, he is the contact PI on an active U01 (HL119578-01A1: Multi-Scale Laws of Myocardial Growth and Remodeling).

      Dr. Guccione graduated with a B.S. in Biomedical Engineering from Tulane University. He obtained his M.S. and Ph.D. in Bioengineering from UCSD. He completed a research fellowship in Biomedical Engineering at The Johns Hopkins University.

      Dr. Guccione has been the recipient of an individual National Research Service Award (F32HL008492: Ventricular Muscle Mechanics Under Physiological Loading). As an assistant professor of biomedical and mechanical engineering at Washington University in St. Louis, he received a Biomedical Engineering Research Grant (Regional Mechanics of Intact Ventricular Muscle) from the Whitaker Foundation and an R01 (HL058759: Regional Mechanics of Left Ventricular Aneurysm). In 1999 he received the Richard Skalak Best Paper Award of the ASME Bioengineering Division.

      My mission at UCSF is to help doctors use realistic simulation to improve the ways they diagnose and treat cardiovascular disease. What if doctors could rely on the same incredible 3D modeling and realistic simulation technology that the aerospace and automotive industries have used for decades to virtually design and test products for optimal performance, reliability and safety? My niche is the development and validation of 3D models of beating human hearts. My students have used those models to realistically simulate the effects of a number of novel surgical procedures and devices on heart function and wall stress, which cannot be measured directly. Last October, in the International Journal of Cardiology we published a study of a novel device that reduced left ventricular wall stress in failing human hearts by 35%! My goal is to use realistic simulation to optimize the design of cardiovascular devices for individual patients.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Burkhoff D, Guccione J. . A new twist on mitral regurgitation. JACC: Basic to Translational Science. 2016; 1:203-6.
      2. Wisneski AD, Mookhoek A, Chitsaz S, Hope MD, Guccione JM, Ge L, Tseng EE. . Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysm: Patient-Specific Finite Element Analysis. Journal of Heart Valve Disease. 2016.
      3. Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM, et al. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico. Int J Artif Organs. 2016 Sep 14; 0. PMID: 27646633.
        View in: PubMed
      4. Kassab GS, An G, Sander EA, Miga MI, Guccione JM, Ji S, Vodovotz Y. Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective. Ann Biomed Eng. 2016 Mar 25. PMID: 27015816.
        View in: PubMed
      5. Lee LC, Kassab GS, Guccione JM. Mathematical modeling of cardiac growth and remodeling. Wiley Interdiscip Rev Syst Biol Med. 2016 May; 8(3):211-26. PMID: 26952285.
        View in: PubMed
      6. Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB. Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone. Ann Thorac Surg. 2016 May; 101(5):1691-9. PMID: 26857634.
        View in: PubMed
      7. Morgan AE, Pantoja JL, Weinsaft J, Grossi E, Guccione J, Ge L, Ratcliffe MB. Finite Element Modeling of Mitral Valve Repair. J Biomech Eng. 2016 Feb 1; 138(2). PMID: 26632260.
        View in: PubMed
      8. Sack KL, Davies NH, Guccione JM, Franz T. Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction. Heart Fail Rev. 2016 Feb 1. PMID: 26833320.
        View in: PubMed
      9. Gullberg G, Aparici CM, Brooks G, Liu J, Guccione J, Saloner D, Seo AY, Ordovas KG. Measuring cardiac efficiency using PET/MRI. EJNMMI Phys. 2015 Dec; 2(Suppl 1):A59. PMID: 26956318.
        View in: PubMed
      10. Pantoja JL, Zhang Z, Tartibi M, Sun K, Macmillan W, Guccione JM, Ge L, Ratcliffe MB. Residual Stress Impairs Pump Function After Surgical Ventricular Remodeling: A Finite Element Analysis. Ann Thorac Surg. 2015 Dec; 100(6):2198-205. PMID: 26341601.
        View in: PubMed
      11. Krishnan K, Ge L, Haraldsson H, Hope MD, Saloner DA, Guccione JM, Tseng EE. Ascending thoracic aortic aneurysm wall stress analysis using patient-specific finite element modeling of in vivo magnetic resonance imaging. Interact Cardiovasc Thorac Surg. 2015 Oct; 21(4):471-80. PMID: 26180089; PMCID: PMC4627354 [Available on 10/01/16].
      12. Genet M, Chuan Lee L, Ge L, Acevedo-Bolton G, Jeung N, Martin A, Cambronero N, Boyle A, Yeghiazarians Y, Kozerke S, Guccione JM. A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging. J Biomech Eng. 2015 Aug; 137(8):081009. PMID: 25994000; PMCID: PMC4476031 [Available on 08/01/16].
      13. Genet M, Lee LC, Baillargeon B, Guccione JM, Kuhl E. Modeling Pathologies of Diastolic and Systolic Heart Failure. Ann Biomed Eng. 2016 Jan; 44(1):112-27. PMID: 26043672.
        View in: PubMed
      14. Genet M, Rausch MK, Lee LC, Choy S, Zhao X, Kassab GS, Kozerke S, Guccione JM, Kuhl E. Heterogeneous growth-induced prestrain in the heart. J Biomech. 2015 Jul 16; 48(10):2080-9. PMID: 25913241; PMCID: PMC4492830 [Available on 07/16/16].
      15. Baillargeon B, Costa I, Leach JR, Lee LC, Genet M, Toutain A, Wenk JF, Rausch MK, Rebelo N, Acevedo-Bolton G, Kuhl E, Navia JL, Guccione JM. Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation. Cardiovasc Eng Technol. 2015; 6(2):105-16. PMID: 25984248; PMCID: PMC4427655.
      16. Wisneski AD, Mookhoek A, Chitsaz S, Hope MD, Guccione JM, Ge L, Tseng EE. Patient-specific finite element analysis of ascending thoracic aortic aneurysm. J Heart Valve Dis. 2014 Nov; 23(6):765-72. PMID: 25790625.
        View in: PubMed
      17. Morrel WG, Ge L, Zhang Z, Grossi EA, Guccione JM, Ratcliffe MB. Effect of mitral annuloplasty device shape and size on leaflet and myofiber stress following repair of posterior leaflet prolapse: a patient-specific finite element simulation. J Heart Valve Dis. 2014 Nov; 23(6):727-34. PMID: 25790620.
        View in: PubMed
      18. Pantoja JL, Ge L, Zhang Z, Morrel WG, Guccione JM, Grossi EA, Ratcliffe MB. Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis. Ann Thorac Surg. 2014 Oct; 98(4):1355-62. PMID: 25130075.
        View in: PubMed
      19. Lee LC, Genet M, Guccione JM. Invited commentary. Ann Thorac Surg. 2014 Jul; 98(1):80. PMID: 24996699.
        View in: PubMed
      20. Lee LC, Wall ST, Genet M, Hinson A, Guccione JM. Bioinjection treatment: effects of post-injection residual stress on left ventricular wall stress. J Biomech. 2014 Sep 22; 47(12):3115-9. PMID: 25065728; PMCID: PMC4163117.
      21. Lee LC, Genet M, Acevedo-Bolton G, Ordovas K, Guccione JM, Kuhl E. A computational model that predicts reverse growth in response to mechanical unloading. Biomech Model Mechanobiol. 2015 Apr; 14(2):217-29. PMID: 24888270; PMCID: PMC4254895 [Available on 04/01/16].
      22. Genet M, Lee LC, Nguyen R, Haraldsson H, Acevedo-Bolton G, Zhang Z, Ge L, Ordovas K, Kozerke S, Guccione JM. Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments. J Appl Physiol (1985). 2014 Jul 15; 117(2):142-52. PMID: 24876359; PMCID: PMC4101610.
      23. Lee LC, Ge L, Zhang Z, Pease M, Nikolic SD, Mishra R, Ratcliffe MB, Guccione JM. Patient-specific finite element modeling of the Cardiokinetix Parachute(®) device: effects on left ventricular wall stress and function. Med Biol Eng Comput. 2014 Jun; 52(6):557-66. PMID: 24793158; PMCID: PMC4118670.
      24. Wisneski AD, Matthews PB, Azadani AN, Mookhoek A, Chitsaz S, Guccione JM, Ge L, Tseng EE. Human pulmonary autograft wall stress at systemic pressures prior to remodeling after the Ross procedure. J Heart Valve Dis. 2014 May; 23(3):377-84. PMID: 25296465.
        View in: PubMed
      25. Lee LC, Genet M, Dang AB, Ge L, Guccione JM, Ratcliffe MB. Applications of computational modeling in cardiac surgery. J Card Surg. 2014 May; 29(3):293-302. PMID: 24708036; PMCID: PMC4045706.
      26. Ge L, Morrel WG, Ward A, Mishra R, Zhang Z, Guccione JM, Grossi EA, Ratcliffe MB. Measurement of mitral leaflet and annular geometry and stress after repair of posterior leaflet prolapse: virtual repair using a patient-specific finite element simulation. Ann Thorac Surg. 2014 May; 97(5):1496-503. PMID: 24630767; PMCID: PMC4121378.
      27. Huo Y, Luo T, Guccione JM, Teague SD, Tan W, Navia JA, Kassab GS. Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis. PLoS One. 2013; 8(9):e73769. PMID: 24058488; PMCID: PMC3772875.
      28. Azadani AN, Chitsaz S, Mannion A, Mookhoek A, Wisneski A, Guccione JM, Hope MD, Ge L, Tseng EE. Biomechanical properties of human ascending thoracic aortic aneurysms. Ann Thorac Surg. 2013 Jul; 96(1):50-8. PMID: 23731613.
        View in: PubMed
      29. Lee LC, Wenk JF, Zhong L, Klepach D, Zhang Z, Ge L, Ratcliffe MB, Zohdi TI, Hsu E, Navia JL, Kassab GS, Guccione JM. Analysis of patient-specific surgical ventricular restoration: importance of an ellipsoidal left ventricular geometry for diastolic and systolic function. J Appl Physiol (1985). 2013 Jul 1; 115(1):136-44. PMID: 23640586; PMCID: PMC3727014.
      30. Wenk JF, Ge L, Zhang Z, Mojsejenko D, Potter DD, Tseng EE, Guccione JM, Ratcliffe MB. Biventricular finite element modeling of the Acorn CorCap Cardiac Support Device on a failing heart. Ann Thorac Surg. 2013 Jun; 95(6):2022-7. PMID: 23643546; PMCID: PMC3702266.
      31. Lee LC, Zhihong Z, Hinson A, Guccione JM. Reduction in left ventricular wall stress and improvement in function in failing hearts using Algisyl-LVR. J Vis Exp. 2013; (74). PMID: 23608998; PMCID: PMC3653384.
      32. Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction. Ann Thorac Surg. 2013 May; 95(5):1619-25. PMID: 23523189; PMCID: PMC3640420.
      33. Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB. Left ventricular pressure gating in ovine cardiac studies: a software-based method. J Biomech Eng. 2013 Mar 1; 135(3):34502. PMID: 24231818; PMCID: PMC3705966.
      34. Lee LC, Wall ST, Klepach D, Ge L, Zhang Z, Lee RJ, Hinson A, Gorman JH, Gorman RC, Guccione JM. Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart. Int J Cardiol. 2013 Oct 3; 168(3):2022-8. PMID: 23394895; PMCID: PMC3748222.
      35. Chitsaz S, Wenk JF, Ge L, Wisneski A, Mookhoek A, Ratcliffe MB, Guccione JM, Tseng EE. Material properties of CorCap passive cardiac support device. Ann Thorac Surg. 2013 Jan; 95(1):148-54. PMID: 22981255; PMCID: PMC3527692.
      36. Wenk JF, Ratcliffe MB, Guccione JM. Finite element modeling of mitral leaflet tissue using a layered shell approximation. Med Biol Eng Comput. 2012 Oct; 50(10):1071-9. PMID: 22971896; PMCID: PMC3477701.
      37. Carrick R, Ge L, Lee LC, Zhang Z, Mishra R, Axel L, Guccione JM, Grossi EA, Ratcliffe MB. Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress. Ann Thorac Surg. 2012 Jun; 93(6):1964-71. PMID: 22560323; PMCID: PMC3470864.
      38. Sankaran S, Esmaily Moghadam M, Kahn AM, Tseng EE, Guccione JM, Marsden AL. Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery. Ann Biomed Eng. 2012 Oct; 40(10):2228-42. PMID: 22539149; PMCID: PMC3570226.
      39. Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB. The benefit of enhanced contractility in the infarct borderzone: a virtual experiment. Front Physiol. 2012; 3:86. PMID: 22509168; PMCID: PMC3321638.
      40. Klepach D, Lee LC, Wenk JF, Ratcliffe MB, Zohdi TI, Navia JA, Kassab GS, Kuhl E, Guccione JM. Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration. Mech Res Commun. 2012 Jun 1; 42:134-141. PMID: 22778489.
        View in: PubMed
      41. Wenk JF, Klepach D, Lee LC, Zhang Z, Ge L, Tseng EE, Martin A, Kozerke S, Gorman JH, Gorman RC, Guccione JM. First evidence of depressed contractility in the border zone of a human myocardial infarction. Ann Thorac Surg. 2012 Apr; 93(4):1188-93. PMID: 22326127; PMCID: PMC3314154.
      42. Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM. A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure. Comput Methods Biomech Biomed Engin. 2013; 16(8):807-18. PMID: 22248290; PMCID: PMC3367128.
      43. Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. Ann Thorac Surg. 2012 Mar; 93(3):776-82. PMID: 22245588; PMCID: PMC3432639.
      44. Wall ST, Guccione JM, Ratcliffe MB, Sundnes JS. Electromechanical feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle: a finite element model study. Am J Physiol Heart Circ Physiol. 2012 Jan 1; 302(1):H206-14. PMID: 22058157; PMCID: PMC3334240.
      45. Wenk J, Guccione J, Ratcliffe M. Invited commentary. Ann Thorac Surg. 2011 Oct; 92(4):1442-3. PMID: 21958794.
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      46. Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction. Ann Thorac Surg. 2011 Nov; 92(5):1614-20. PMID: 21945222; PMCID: PMC3253877.
      47. Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM. A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction. J Biomech Eng. 2011 Sep; 133(9):094506. PMID: 22010752; PMCID: PMC3207355.
      48. Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM. A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction. Ann Thorac Surg. 2011 Sep; 92(3):935-41. PMID: 21871280; PMCID: PMC3184306.
      49. Zhao X, Wenk JF, Burger M, Liu Y, Das MK, Combs W, Ge L, Guccione JM, Kassab GS. Simulation of mechanical environment in active lead fixation: effect of fixation helix size. J Biomech Eng. 2011 Jun; 133(6):061006. PMID: 21744926.
        View in: PubMed
      50. Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM. Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction. J Biomech Eng. 2011 Apr; 133(4):044501. PMID: 21428685; PMCID: PMC3097530.
      51. Zhao X, Burger M, Liu Y, Das MK, Combs W, Wenk JF, Guccione JM, Kassab GS. Simulation of LV pacemaker lead in marginal vein: potential risk factors for acute dislodgement. J Biomech Eng. 2011 Mar; 133(3):031006. PMID: 21303182.
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      52. Zhong L, Su Y, Gobeawan L, Sola S, Tan RS, Navia JL, Ghista DN, Chua T, Guccione J, Kassab GS. Impact of surgical ventricular restoration on ventricular shape, wall stress, and function in heart failure patients. Am J Physiol Heart Circ Physiol. 2011 May; 300(5):H1653-60. PMID: 21357513; PMCID: PMC3094088.
      53. Matthews PB, Jhun CS, Yaung S, Azadani AN, Guccione JM, Ge L, Tseng EE. Finite element modeling of the pulmonary autograft at systemic pressure before remodeling. J Heart Valve Dis. 2011 Jan; 20(1):45-52. PMID: 21404897.
        View in: PubMed
      54. Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB. Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling. Ann Thorac Surg. 2011 Jan; 91(1):150-6. PMID: 21172505; PMCID: PMC3058250.
      55. Matthews PB, Azadani AN, Jhun CS, Ge L, Guy TS, Guccione JM, Tseng EE. Comparison of porcine pulmonary and aortic root material properties. Ann Thorac Surg. 2010 Jun; 89(6):1981-8. PMID: 20494060.
        View in: PubMed
      56. Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. Ann Thorac Surg. 2010 May; 89(5):1546-53. PMID: 20417775; PMCID: PMC2887313.
      57. Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB. Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone. J Thorac Cardiovasc Surg. 2010 Jul; 140(1):233-9, 239.e1-4. PMID: 20299030; PMCID: PMC2907919.
      58. Einstein DR, Del Pin F, Jiao X, Kuprat AP, Carson JP, Kunzelman KS, Cochran RP, Guccione JM, Ratcliffe MB. Fluid-Structure Interactions of the Mitral Valve and Left Heart: Comprehensive Strategies, Past, Present and Future. Int J Numer Methods Eng. 2010 Mar; 26(3-4):348-380. PMID: 20454531.
        View in: PubMed
      59. Jhun CS, Wenk JF, Zhang Z, Wall ST, Sun K, Sabbah HN, Ratcliffe MB, Guccione JM. Effect of adjustable passive constraint on the failing left ventricle: a finite-element model study. Ann Thorac Surg. 2010 Jan; 89(1):132-7. PMID: 20103222; PMCID: PMC2844501.
      60. Wenk JF, Wall ST, Peterson RC, Helgerson SL, Sabbah HN, Burger M, Stander N, Ratcliffe MB, Guccione JM. A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns. J Biomech Eng. 2009 Dec; 131(12):121011. PMID: 20524734.
        View in: PubMed
      61. Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm. J Biomech Eng. 2009 Nov; 131(11):111001. PMID: 20016753.
        View in: PubMed
      62. Matthews PB, Kim B, Azadani AN, Guy TS, Guccione JM, Ge L, Tseng EE. Biomechanical perspective on the porcine pulmonary root prior to Ross remodeling. J Heart Valve Dis. 2009 Nov; 18(6):682-90. PMID: 20099718.
        View in: PubMed
      63. Carson JP, Kuprat AP, Jiao X, Dyedov V, Del Pin F, Guccione JM, Ratcliffe MB, Einstein DR. Adaptive generation of multimaterial grids from imaging data for biomedical Lagrangian fluid-structure simulations. Biomech Model Mechanobiol. 2010 Apr; 9(2):187-201. PMID: 19727874; PMCID: PMC2837787.
      64. Azadani AN, Jaussaud N, Matthews PB, Chuter TA, Ge L, Guy TS, Guccione J, Tseng EE. Aortic valve-in-valve implantation: impact of transcatheter- bioprosthesis size mismatch. J Heart Valve Dis. 2009 Jul; 18(4):367-73. PMID: 19852139.
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      65. Gundiah N, Matthews PB, Karimi R, Azadani A, Guccione J, Guy TS, Saloner D, Tseng EE. Significant material property differences between the porcine ascending aorta and aortic sinuses. J Heart Valve Dis. 2008 Nov; 17(6):606-13. PMID: 19137790.
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      66. Gundiah N, Kam K, Matthews PB, Guccione J, Dwyer HA, Saloner D, Chuter TA, Guy TS, Ratcliffe MB, Tseng EE. Asymmetric mechanical properties of porcine aortic sinuses. Ann Thorac Surg. 2008 May; 85(5):1631-8. PMID: 18442553.
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      67. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg. 2008 May; 135(5):1094-102, 1102.e1-2. PMID: 18455590; PMCID: PMC3773224.
      68. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J Thorac Cardiovasc Surg. 2007 Oct; 134(4):1017-24. PMID: 17903523; PMCID: PMC2615826.
      69. Jiang Y, Guccione JM, Ratcliffe MB, Hsu EW. Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2377-84. PMID: 17604331.
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      70. Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM. Theoretical impact of the injection of material into the myocardium: a finite element model simulation. Circulation. 2006 Dec 12; 114(24):2627-35. PMID: 17130342.
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      71. Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB. The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. J Thorac Cardiovasc Surg. 2006 Mar; 131(3):579-586.e3. PMID: 16515908; PMCID: PMC1482534.
      72. Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB. Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep. J Thorac Cardiovasc Surg. 2005 Oct; 130(4):1032-8. PMID: 16214516; PMCID: PMC1475735.
      73. Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM. MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol. 2005 Aug; 289(2):H692-700. PMID: 15778283.
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      74. Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB. Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. J Thorac Cardiovasc Surg. 2005 Feb; 129(2):382-90. PMID: 15678050.
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      75. Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Ann Thorac Surg. 2005 Jan; 79(1):185-93. PMID: 15620941.
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      76. Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB. Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1844-50. PMID: 15604126.
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      77. Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB. Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study. Ann Thorac Surg. 2003 Oct; 76(4):1171-80; discussion 1180. PMID: 14530007.
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      78. Moustakidis P, Maniar HS, Cupps BP, Absi T, Zheng J, Guccione JM, Sundt TM, Pasque MK. Altered left ventricular geometry changes the border zone temporal distribution of stress in an experimental model of left ventricular aneurysm: a finite element model study. Circulation. 2002 Sep 24; 106(12 Suppl 1):I168-75. PMID: 12354728.
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      79. Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy. ASAIO J. 2002 Sep-Oct; 48(5):508-13. PMID: 12296571.
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      80. Guccione JM, Moonly SM, Wallace AW, Ratcliffe MB. Residual stress produced by ventricular volume reduction surgery has little effect on ventricular function and mechanics: a finite element model study. J Thorac Cardiovasc Surg. 2001 Sep; 122(3):592-9. PMID: 11547315.
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      81. Guccione JM, Moonly SM, Moustakidis P, Costa KD, Moulton MJ, Ratcliffe MB, Pasque MK. Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study. Ann Thorac Surg. 2001 Feb; 71(2):654-62. PMID: 11235723.
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      82. Okamoto RJ, Moulton MJ, Peterson SJ, Li D, Pasque MK, Guccione JM. Epicardial suction: a new approach to mechanical testing of the passive ventricular wall. J Biomech Eng. 2000 Oct; 122(5):479-87. PMID: 11091948.
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      83. Zahalak GI, de Laborderie V, Guccione JM. The effects of cross-fiber deformation on axial fiber stress in myocardium. J Biomech Eng. 1999 Aug; 121(4):376-85. PMID: 10464691.
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      84. Guccione JM, Motabarzadeh I, Zahalak GI. A distribution-moment model of deactivation in cardiac muscle. J Biomech. 1998 Nov; 31(11):1069-73. PMID: 9880065.
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      85. Guccione JM, Le Prell GS, de Tombe PP, Hunter WC. Measurements of active myocardial tension under a wide range of physiological loading conditions. J Biomech. 1997 Feb; 30(2):189-92. PMID: 9001940.
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      86. Guccione JM, O'Dell WG, McCulloch AD, Hunter WC. Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection. Am J Physiol. 1997 Jan; 272(1 Pt 2):H469-77. PMID: 9038969.
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      87. Costa KD, Hunter PJ, Wayne JS, Waldman LK, Guccione JM, McCulloch AD. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II--Prolate spheroidal coordinates. J Biomech Eng. 1996 Nov; 118(4):464-72. PMID: 8950649.
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      88. Costa KD, Hunter PJ, Rogers JM, Guccione JM, Waldman LK, McCulloch AD. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: I--Cylindrical and spherical polar coordinates. J Biomech Eng. 1996 Nov; 118(4):452-63. PMID: 8950648.
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      89. Guccione JM, Costa KD, McCulloch AD. Finite element stress analysis of left ventricular mechanics in the beating dog heart. J Biomech. 1995 Oct; 28(10):1167-77. PMID: 8550635.
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      90. Guccione JM, Waldman LK, McCulloch AD. Mechanics of active contraction in cardiac muscle: Part II--Cylindrical models of the systolic left ventricle. J Biomech Eng. 1993 Feb; 115(1):82-90. PMID: 8445902.
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      91. Guccione JM, McCulloch AD. Mechanics of active contraction in cardiac muscle: Part I--Constitutive relations for fiber stress that describe deactivation. J Biomech Eng. 1993 Feb; 115(1):72-81. PMID: 8445901.
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      92. McCulloch A, Waldman L, Rogers J, Guccione J. Large-scale finite element analysis of the beating heart. Crit Rev Biomed Eng. 1992; 20(5-6):427-49. PMID: 1486784.
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      93. Guccione JM, McCulloch AD, Waldman LK. Passive material properties of intact ventricular myocardium determined from a cylindrical model. J Biomech Eng. 1991 Feb; 113(1):42-55. PMID: 2020175.
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