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Liviu Klein, MD, MS

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-502-8584
EmailLiviu.Klein@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    Carol Davila School of MedicineMD 1999Medicine
    Northwestern UniversityMSCI2005Graduate School
    University Hospital BucharestResident2000Internal Medicine
    Advocate Illinois Masonic Medical CenterResident2003Internal Medicine
    Northwestern UniversityFellow2005Cardiovascular Epidemiology
    Northwestern Memorial HospitalFellow2007Cardiovascular Disease
    Northwestern Memorial HospitalFellow2008Advanced Heart Failure and Transplantation
    Northwestern Memorial HospitalFellow2009Clinical Cardiac Electrophysiology
    Collapse Awards and Honors
    International Society for Rotary Blood Pumps2016Sezai Innovative Research Award
    University of California San Francisco2013Cardiology Faculty Teaching Award
    Northwestern University Feinberg School of Medicine2009Larry Jameson Research Award
    Advocate Illinois Masonic Medical Center2003Outstanding Senior Resident Award

    Collapse Overview 
    Collapse Overview
    CLINICAL INTERESTS
    My clinical interests are heart failure and cardiac arrhythmias in patients with heart failure. Having advanced training in both heart failure and electrophysiology, I practice an integrated approach in treating patients with heart failure and cardiac arrhythmias. I am also interested in cardiac recovery using electrical (i.e. cardiac resynchronization) and mechanical (i.e. ventricular assist devices) therapies. I treat patients across the heart failure spectrum, from early diagnosis to heart transplantation.

    RESEARCH INTERESTS
    My research is aimed at understanding the epidemiology of heart failure in women and sudden cardiac death in women with heart failure. In addition, I am developing new diagnostic sensors and therapeutic devices for patients with cardiovascular disease, including patients with heart failure.


    Collapse Research 
    Collapse Research Activities and Funding
    WHISH-2-Prevent Heart Failure Study
    NIH R01HL130591Aug 1, 2016 - May 31, 2021
    Role: Co-Investigator
    Non-invasive biosensors to detect cardiovascular changes in heart failure
    NIH R01HL130619May 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Wearable Cardiomechanics Monitor to Decrease Heart Failure Readmissions
    NIH R56AG048458Sep 30, 2015 - Aug 31, 2016
    Role: Principal Investigator
    CorBand: A novel wearable wrist sensor for heart failure remote monitoring
    NIH R44HL125001Aug 1, 2014 - Jul 31, 2018
    Role: Co-Investigator
    Heart Failure Evaluation in Post-Menopausal Women: The Women's Health Initiative
    NIH R21AG027471Sep 30, 2007 - Aug 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Hall PS, Nah G, Howard BV, Lewis CE, Allison MA, Sarto GE, Waring ME, Jacobson LT, Manson JE, Klein L, Parikh NI. Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative. J Am Coll Cardiol. 2017 May 23; 69(20):2517-2526. PMID: 28521890.
      View in: PubMed
    2. Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, Allen NB, de Lemos JA, Carnethon M, Greenland P, Berry JD. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure. J Am Coll Cardiol. 2017 Mar 07; 69(9):1129-1142. PMID: 28254175.
      View in: PubMed
    3. Cowie MR, Simon M, Klein L, Thokala P. The cost-effectiveness of real-time pulmonary artery pressure monitoring in heart failure patients: a European perspective. Eur J Heart Fail. 2017 Feb 07. PMID: 28176424.
      View in: PubMed
    4. Brondfield MN, Reid MJ, Rutishauser RL, Cope JR, Tang J, Ritter JM, Matanock A, Ali I, Doernberg SB, Hilts-Horeczko A, DeMarco T, Klein L, Babik JM. Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. Transpl Infect Dis. 2017 Jan 09. PMID: 28067969.
      View in: PubMed
    5. Eaton CB, Pettinger M, Rossouw J, Martin LW, Foraker R, Quddus A, Liu S, Wampler NS, Hank Wu WC, Manson JE, Margolis K, Johnson KC, Allison M, Corbie-Smith G, Rosamond W, Breathett K, Klein L, et al. Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women. Circ Heart Fail. 2016 Oct; 9(10). PMID: 27682440.
      View in: PubMed
    6. Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM, et al. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico. Int J Artif Organs. 2016 Sep 14; 0. PMID: 27646633.
      View in: PubMed
    7. Klein L. Treating Hemodynamic Congestion Is the Key to Prevent Heart Failure Hospitalizations. JACC Heart Fail. 2016 May; 4(5):345-7. PMID: 27126282.
      View in: PubMed
    8. Klein L, Greenberg BH, Konstam MA, Gregory D, Kociol RD, Johnson MR, De Marco T. Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey. J Card Fail. 2015 Nov; 21(11):924-9. PMID: 26362520.
      View in: PubMed
    9. Rogers SE, Klein L, Perissinotto CM. The importance of cognitive assessment before ventricular device placement: a teachable moment. JAMA Intern Med. 2015 Jun; 175(6):890. PMID: 25822770.
      View in: PubMed
    10. Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S. A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables. IEEE Trans Biomed Circuits Syst. 2016 Apr; 10(2):280-8. PMID: 25974943.
      View in: PubMed
    11. Donneyong MM, Hornung CA, Taylor KC, Baumgartner RN, Myers JA, Eaton CB, Gorodeski EZ, Klein L, Martin LW, Shikany JM, Song Y, Li W, Manson JE. Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative. Circ Heart Fail. 2015 Jan; 8(1):49-56. PMID: 25398967; PMCID: PMC4303506 [Available on 01/01/16].
    12. Wiens AD, Etemadi M, Roy S, Klein L, Inan OT. Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography. IEEE J Biomed Health Inform. 2015 Jul; 19(4):1435-42. PMID: 25265619; PMCID: PMC4532376 [Available on 07/01/16].
    13. Klein L, Hsia H. Sudden cardiac death in heart failure. Cardiol Clin. 2014 Feb; 32(1):135-44, ix. PMID: 24286584.
      View in: PubMed
    14. Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT. Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5188-91. PMID: 25571162; PMCID: PMC4600348.
    15. Wiens A, Etemadi M, Klein L, Roy S, Inan OT. Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5172-5. PMID: 25571158; PMCID: PMC4605430.
    16. Sridharan L, Klein L. Prognostic factors in patients hospitalized for heart failure. Curr Heart Fail Rep. 2013 Dec; 10(4):380-6. PMID: 24122287.
      View in: PubMed
    17. Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML. Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study. Heart. 2013 Aug; 99(16):1173-8. PMID: 23756655.
      View in: PubMed
    18. Perez MV, Wang PJ, Larson JC, Virnig BA, Cochrane B, Curb JD, Klein L, Manson JE, Martin LW, Robinson J, Wassertheil-Smoller S, Stefanick ML. Effects of postmenopausal hormone therapy on incident atrial fibrillation: the Women's Health Initiative randomized controlled trials. Circ Arrhythm Electrophysiol. 2012 Dec; 5(6):1108-16. PMID: 23169946.
      View in: PubMed
    19. Klein L. ACP Journal Club. Review: new oral anticoagulants reduced stroke and systemic embolism compared with warfarin in AF. Ann Intern Med. 2012 Sep 18; 157(6):JC3-2. PMID: 22986394.
      View in: PubMed
    20. Avery CL, Sethupathy P, Buyske S, He Q, Lin DY, Arking DE, Carty CL, Duggan D, Fesinmeyer MD, Hindorff LA, Jeff JM, Klein L, Patton KK, Peters U, Shohet RV, Sotoodehnia N, Young AM, Kooperberg C, Haiman CA, Mohlke KL, Whitsel EA, North KE. Fine-mapping and initial characterization of QT interval loci in African Americans. PLoS Genet. 2012; 8(8):e1002870. PMID: 22912591; PMCID: PMC3415454.
    21. Eaton CB, Abdulbaki AM, Margolis KL, Manson JE, Limacher M, Klein L, Allison MA, Robinson JG, Curb JD, Martin LA, Liu S, Howard BV. Racial and ethnic differences in incident hospitalized heart failure in postmenopausal women: the Women's Health Initiative. Circulation. 2012 Aug 7; 126(6):688-96. PMID: 22753306; PMCID: PMC4618499.
    22. Klein L. Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3. PMID: 22250165.
      View in: PubMed
    23. Klein L. Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillation. Ann Intern Med. 2012 Jan 17; 156(2):JC1-2, JC1-3. PMID: 22250164.
      View in: PubMed
    24. Shah RU, Winkleby MA, Van Horn L, Phillips LS, Eaton CB, Martin LW, Rosal MC, Manson JE, Ning H, Lloyd-Jones DM, Klein L. Education, income, and incident heart failure in post-menopausal women: the Women's Health Initiative Hormone Therapy Trials. J Am Coll Cardiol. 2011 Sep 27; 58(14):1457-64. PMID: 21939829; PMCID: PMC3635103.
    25. Klein L, Grau-Sepulveda MV, Bonow RO, Hernandez AF, Williams MV, Bhatt DL, Fonarow GC. Quality of care and outcomes in women hospitalized for heart failure. Circ Heart Fail. 2011 Sep; 4(5):589-98. PMID: 21862732.
      View in: PubMed
    26. Klein L. Omnes viae Romam ducunt: Asymptomatic cardiac and noncardiac organ system dysfunction leads to heart failure. Circulation. 2011 Jul 5; 124(1):4-6. PMID: 21730317.
      View in: PubMed
    27. Svetlichnaya J, Klein L. Atrial fibrillation in elderly patients with heart failure: convergence of two cardiovascular epidemics in the 21st Century. Expert Rev Cardiovasc Ther. 2011 Jul; 9(7):903-12. PMID: 21809972.
      View in: PubMed
    28. Tempelhof MW, Klein L, Cotts WG, Benzuly KH, Davidson CJ, Meyers SN, McCarthy PM, Malaisrie CS, McGee EC, Beohar N. Clinical experience and patient outcomes associated with the TandemHeart percutaneous transseptal assist device among a heterogeneous patient population. ASAIO J. 2011 Jul-Aug; 57(4):254-61. PMID: 21546824.
      View in: PubMed
    29. Shah RU, Tsai V, Klein L, Heidenreich PA. Characteristics and outcomes of very elderly patients after first hospitalization for heart failure. Circ Heart Fail. 2011 May; 4(3):301-7. PMID: 21467294.
      View in: PubMed
    30. Klein L. ACP Journal Club. Higher-dose dabigatran reduced stroke, but not major hemorrhage, more than warfarin in atrial fibrillation. Ann Intern Med. 2010 Jan 19; 152(2):JC1-2. PMID: 20083817.
      View in: PubMed
    31. Shah RU, Klein L, Lloyd-Jones DM. Heart failure in women: epidemiology, biology and treatment. Womens Health (Lond Engl). 2009 Sep; 5(5):517-27. PMID: 19702451.
      View in: PubMed
    32. Klein L, Massie BM, Leimberger JD, O'Connor CM, Piña IL, Adams KF, Califf RM, Gheorghiade M. Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF). Circ Heart Fail. 2008 May; 1(1):25-33. PMID: 19808267.
      View in: PubMed
    33. Klein L, O'connell JB. Thromboembolic risk in the patient with heart failure. Curr Treat Options Cardiovasc Med. 2007 Aug; 9(4):310-7. PMID: 17761116.
      View in: PubMed
    34. Lloyd-Jones DM, Liu K, Colangelo LA, Yan LL, Klein L, Loria CM, Lewis CE, Savage P. Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Circulation. 2007 Feb 27; 115(8):1004-11. PMID: 17283263.
      View in: PubMed
    35. Gheorghiade M, Zannad F, Sopko G, Klein L, Piña IL, Konstam MA, Massie BM, Roland E, Targum S, Collins SP, Filippatos G, Tavazzi L. Acute heart failure syndromes: current state and framework for future research. Circulation. 2005 Dec 20; 112(25):3958-68. PMID: 16365214.
      View in: PubMed
    36. De Luca L, Klein L, Udelson JE, Orlandi C, Sardella G, Fedele F, Gheorghiade M. Hyponatremia in patients with heart failure. Am J Cardiol. 2005 Dec 19; 96(12A):19L-23L. PMID: 16399089.
      View in: PubMed
    37. Klein L, O'Connor CM, Leimberger JD, Gattis-Stough W, Piña IL, Felker GM, Adams KF, Califf RM, Gheorghiade M. Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. Circulation. 2005 May 17; 111(19):2454-60. PMID: 15867182.
      View in: PubMed
    38. Klein L. Posting treatment recommendations to primary care physicians does not improve care for people with myocardial infarction or heart failure. Commentary. Evid Based Cardiovasc Med. 2005 Mar; 9(1):72-5. PMID: 16379994.
      View in: PubMed
    39. Klein L, Gheorghiade M. Coronary artery disease and prevention of heart failure. Med Clin North Am. 2004 Sep; 88(5):1209-35. PMID: 15331314.
      View in: PubMed
    40. Danciu SC, Klein L, Hosseini MM, Ibrahim L, Coyle BW, Kehoe RF. A predictive model for survival after in-hospital cardiopulmonary arrest. Resuscitation. 2004 Jul; 62(1):35-42. PMID: 15246581.
      View in: PubMed
    41. Klein L, Galvez A, Klein L, Chediak J. Warfarin-induced limb gangrene in the setting of lung adenocarcinoma. Am J Hematol. 2004 Jun; 76(2):176-9. PMID: 15164386.
      View in: PubMed
    42. Klein L, Gattis WA, Borrello F, Wu E, O'Connor CM, Gheorghiade M. Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study. Am J Cardiol. 2004 Apr 22; 93(8A):44A-46A. PMID: 15094106.
      View in: PubMed
    43. Klein L, Gheorghiade M. Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update. Am J Med. 2004 Mar 8; 116 Suppl 5A:47S-63S. PMID: 15019863.
      View in: PubMed
    44. Piccini JP, Klein L, Gheorghiade M, Bonow RO. New insights into diastolic heart failure: role of diabetes mellitus. Am J Med. 2004 Mar 8; 116 Suppl 5A:64S-75S. PMID: 15019864.
      View in: PubMed
    45. Gheorghiade M, Klein L, Stone NJ, Bonow RO, Kim RJ. Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin. Ital Heart J. 2004 Feb; 5(2):160-2. PMID: 15086148.
      View in: PubMed
    46. Klein L, O'Connor CM, Gattis WA, Zampino M, de Luca L, Vitarelli A, Fedele F, Gheorghiade M. Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations. Am J Cardiol. 2003 May 8; 91(9A):18F-40F. PMID: 12729848.
      View in: PubMed
    47. Jain P, Massie BM, Gattis WA, Klein L, Gheorghiade M. Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. Am Heart J. 2003 Feb; 145(2 Suppl):S3-17. PMID: 12594447.
      View in: PubMed
    48. Klein L, Gheorghiade M. Therapeutic strategies for patients hospitalized with worsening heart failure. Ital Heart J. 2003 Feb; 4(2):71-4. PMID: 12762267.
      View in: PubMed
    49. Borrello F, Beahan M, Klein L, Gheorghiade M. Reappraisal of beta-blocker therapy in the acute and chronic post-myocardial infarction period. Rev Cardiovasc Med. 2003; 4 Suppl 3:S13-24. PMID: 14564230.
      View in: PubMed
    50. Gheorghiade M, Gattis WA, Klein L. OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization. Eur J Heart Fail. 2003 Jan; 5(1):9-12. PMID: 12559209.
      View in: PubMed
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