Joseph Leach, MD, PhD

Title(s)Assistant Professor, Radiology
SchoolSchool of Medicine
Address400 Parnassus Avenue, #C-106B
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    UCSF, Department of Radiology & Biomedical Imaging, San Francisco, CAFellowship2019Abdominal Imaging; Ultrasound
    UCSF, Department of Radiology & Biomedical Imaging, San Francisco, CAResidency2018Diagnostic Radiology
    UCSF, Department of Radiology & Biomedical Imaging, San Francisco, CANIH T32 Research Fellowship2018
    California Pacific Medical Center, San Francisco, CAInternship2014Internal Medicine
    UCSF, School of Medicine, San Francisco, CAMD2013Medicine
    UCSF-UC Berkeley Joint Bioengineering Program, San Francisco, CAPhD2009Bioengineering
    Collapse Awards and Honors
    Margulis Society, UCSF Radiology & Biomedical Imaging2018Outstanding Resident Research Award

    Collapse Overview 
    Collapse Overview
    Joseph Leach, MD, PhD obtained his PhD from the joint UCSF-UC Berkeley Bioengineering program in 2009. In 2013 Dr. Leach earned his medical degree at UCSF, followed by a one-year Internal Medicine internship at California Pacific Medical Center of San Francisco, where he was awarded "Francis J Rigney Intern of the Year". Dr. Leach completed a four-year Diagnostic Radiology residency at UCSF in 2018, spending 2017-2018 as an NIH T32 Training Grant research fellow, where he focused his research on the development of methodologies by which to study the biomechanics of abdominal aortic aneurysms (AAA) on a patient-specific basis. Dr. Leach completed a clinical fellowship in Abdominal Imaging/Ultrasound at UCSF in 2019 and joined the department as an assistant professor in residence in the section of Abdominal Imaging and Ultrasound later the same year. In addition to his clinical role at UCSF, Dr Leach maintains an active research program, studying the imaging and biomechanics of vascular disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Combined Magnetic Resonance Imaging and Biomechanical Analysis of Abdominal Aortic Aneurysms to Predict Disease Progression
    RSNA RF1813Jul 18, 2018 - Jul 17, 2020

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm. Int J Cardiol Heart Vasc. 2024 Apr; 51:101375. Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach JR, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 38435381; PMCID: PMC10909604.
      View in: PubMed   Mentions:
    2. Sex differences in ascending aortic size reporting and growth on chest computed tomography and magnetic resonance imaging. Clin Imaging. 2024 Jan; 105:110021. Zamirpour S, Boskovski MT, Pirruccello JP, Pace WA, Hubbard AE, Leach JR, Ge L, Tseng EE. PMID: 37992628.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Measurement of Abdominal Aortic Aneurysm Strain Using MR Deformable Image Registration: Accuracy and Relationship to Recent Aneurysm Progression. Invest Radiol. 2023 Oct 19. Dong H, Leach JR, Kao E, Zhou A, Chitiboi T, Zhu C, Ballweber M, Jiang F, Lee YJ, Iannuzzi J, Gasper W, Saloner D, Hope MD, Mitsouras D. PMID: 37855728.
      View in: PubMed   Mentions:    Fields:    
    4. Aortic area/height ratio, peak wall stresses, and outcomes in veterans with tricuspid versus bicuspid aortic valve-associated ascending thoracic aortic aneurysms. J Thorac Cardiovasc Surg. 2023 12; 166(6):1583-1593.e2. Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 37295642.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population. Eur J Cardiothorac Surg. 2023 06 01; 63(6). Gulati A, Zamirpour S, Leach J, Khan A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 37354525; PMCID: PMC10301688.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Contrast-enhanced CT radiomics improves the prediction of abdominal aortic aneurysm progression. Eur Radiol. 2023 May; 33(5):3444-3454. Wang Y, Xiong F, Leach J, Kao E, Tian B, Zhu C, Zhang Y, Hope M, Saloner D, Mitsouras D. PMID: 36920519.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Dynamic Contrast-Enhanced MRI in Abdominal Aortic Aneurysms as a Potential Marker for Disease Progression. J Magn Reson Imaging. 2023 10; 58(4):1258-1267. Zhou A, Leach JR, Zhu C, Dong H, Jiang F, Lee YJ, Iannuzzi J, Gasper W, Saloner D, Hope MD, Mitsouras D. PMID: 36747321.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Editorial: Advances in aortic imaging. Front Cardiovasc Med. 2023; 10:1137949. Leach JR, Zhu C, Burris N, Hope MD. PMID: 36818356; PMCID: PMC9929938.
      View in: PubMed   Mentions:
    9. Abstract 14350: CVSA Early Career Investigator Award Finalist: Association of Aneurysm Wall Stresses With Diameter Indices and Three-Year Outcomes in Veterans. Circulation. 2022 Nov 8; 146(Suppl_1):a14350-a14350. Zamirpour ZS, Yue YX, Wang WZ, Gomez GA, Hope HM, LEACH LJ, Saloner SD, Guccione GJ, Ge GL, Tseng TE. .
      View in: Publisher Site   Mentions:
    10. Impact of Implicit Abdominal Aortic Aneurysm Screening in the Veterans Affairs Health Care System Over 10 Years. Journal of Vascular Surgery. 2022 Jul 1; 76(1):304. Leach LJ, Shen SH, Huo HE, Hope HT, Mitsouras MD, Whooley WM. .
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    11. Association of 3-Year All-Cause Mortality and Peak Wall Stresses of Ascending Thoracic Aortic Aneurysms in Veterans. Semin Thorac Cardiovasc Surg. 2023 Autumn; 35(3):447-456. Zamirpour S, Xuan Y, Wang Z, Gomez A, Hope MD, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE. PMID: 35690227.
      View in: PubMed   Mentions: 1     Fields:    
    12. Impact of Implicit Abdominal Aortic Aneurysm Screening in the Veterans Affairs Health Care System Over 10 Years. J Am Heart Assoc. 2022 04 05; 11(7):e024571. Leach JR, Shen H, Huo E, Hope TA, Mitsouras D, Whooley MA, Hope MD. PMID: 35348001; PMCID: PMC9075479.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    13. Ascending thoracic aortic aneurysm growth is minimal at sizes that do not meet criteria for surgical repair. Quant Imaging Med Surg. 2022 Jan; 12(1):333-340. Gulati A, Leach J, Wang Z, Xuan Y, Hope MD, Saloner DA, Ge L, Tseng EE. PMID: 34993082; PMCID: PMC8666776.
      View in: PubMed   Mentions: 2  
    14. Abstract 9061: Aortic Wall Stress Across Risk Groupings of Aortic Size and Height Indices in a Male Veteran Population With Ascending Thoracic Aortic Aneurysm. Circulation. 2021 Nov 16; 144(Suppl_1):a9061-a9061. Zamirpour ZS, Xuan XY, Wang WZ, Gomez GA, Hope HM, Leach LJ, Saloner SD, Guccione GJ, Ge GL, Tseng TE. .
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    15. Ascending Thoracic Aortic Aneurysm Growth is Minimal at Sizes That Do Not Meet Criteria for Surgical Repair. Structural Heart. 2021 Apr 9; 5(sup1):63-63. Gulati GA, Leach LJ, Wang WZ, Xuan XY, Hope HM, Ge GL, Tseng TE. .
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    16. Abdominal aortic aneurysm measurement at CT/MRI: potential clinical ramifications of non-standardized measurement technique and importance of multiplanar reformation. Quant Imaging Med Surg. 2021 Feb; 11(2):823-830. Leach JR, Zhu C, Mitsouras D, Saloner D, Hope MD. PMID: 33532280; PMCID: PMC7779927.
      View in: PubMed   Mentions:
    17. Mesh on the move: a case report of total transmural surgical mesh migration causing bowel obstruction. Clin J Gastroenterol. 2021 Feb; 14(1):136-140. Leach JR, Manoukian B, Stewart L. PMID: 33241525.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Abstract 16957: Ascending Thoracic Aortic Aneurysm Wall Stresses Evolve in Parallel With Diameter Growth. Circulation. 2020 Nov 17; 142(Suppl_3). Gulati GA, Wang WZ, XUAN XY, LEACH LJ, Hope HM, Saloner SD, Guccione GJ, Ge GL, Tseng TE. .
      View in: Publisher Site   Mentions:
    19. Computer-aided quantification of non-contrast 3D black blood MRI as an efficient alternative to reference standard manual CT angiography measurements of abdominal aortic aneurysms. Eur J Radiol. 2021 Jan; 134:109396. Wang Y, Tian B, Xiong F, Kao E, Zhang Y, Liu X, Tian X, Haraldsson H, Zhu C, Leach J, Liu J, Hope MD, Mitsouras D, Saloner D. PMID: 33217686.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Computer-Aided Quantification of Non-contrast 3D Black Blood MRI As An Efficient Alternative to Reference Standard Manual CT Angiography Measurements of Abdominal Aortic Aneurysms. European Journal of Radiology. 2020 Nov 1; 109396. Wang WY, Tian TB, Xiong XF, Kao KE, Zhang ZY, Liu LX, Tian TX, Haraldsson HH, Zhu ZC, Leach LJ, Liu LJ, Hope HM, Mitsouras MD, Saloner SD. .
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    21. Wall Stress Changes in Ascending Thoracic Aortic Aneurysms Do Not Correlate with Changes in Diameter over Time. Journal of the American College of Surgeons. 2020 Oct 1; 231(4):s49. Gulati GA, Wang WZ, Xuan XY, Leach LJ, Saloner SD, Guccione GJ, Ge GL, Tseng TE. .
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    22. Expanding the Radiologist's Arsenal against Abdominal Aortic Aneurysms, a Versatile Adversary. Radiology. 2020 06; 295(3):730-732. Mitsouras D, Leach JR. PMID: 32233921; PMCID: PMC7263282.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Growth of common iliac artery aneurysms coexisting with abdominal aortic aneurysms: associated factors and potential role of intraluminal thrombus. Quant Imaging Med Surg. 2020 Mar; 10(3):703-712. Wang Y, Zhu C, Leach J, Gasper W, Saloner D, Hope M. PMID: 32269930; PMCID: PMC7136736.
      View in: PubMed   Mentions:
    24. Intraluminal Thrombus Predicts Rapid Growth of Abdominal Aortic Aneurysms. Radiology. 2020 03; 294(3):707-713. Zhu C, Leach JR, Wang Y, Gasper W, Saloner D, Hope MD. PMID: 31990263; PMCID: PMC7051169.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    25. Sound Measurement in Patient-Specific 3D Printed Bench Models of Venous Pulsatile Tinnitus. Otology & Neurotology. 2020 Jan 1; 41(1):e7-e14. Valluru VK, Parkhill PJ, Gautam GA, Haraldsson HH, Kao KE, Leach LJ, Wright WA, Ballweber BM, Meisel MK, Saloner SD, Amans AM. .
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    26. On the Relative Impact of Intraluminal Thrombus Heterogeneity on Abdominal Aortic Aneurysm Mechanics. J Biomech Eng. 2019 Nov 01; 141(11). Leach JR, Kao E, Zhu C, Saloner D, Hope MD. PMID: 31253989; PMCID: PMC6808003.
      View in: PubMed   Mentions: 1     Fields:    
    27. O-025 Sound measurement in patient-specific 3D printed bench models for venous pulsatile tinnitus. Journal of NeuroInterventional Surgery. 2019 Jul 1; 11(Suppl 1):a17. Amans AM, Valluru VK, Haraldsson HH, Kao KE, Leach LJ, Wright WA, Ballweber BM, Meisel MK, Saloner SD. .
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    29. Evaluation of the distribution and progression of intraluminal thrombus in abdominal aortic aneurysms using high-resolution MRI. J Magn Reson Imaging. 2019 09; 50(3):994-1001. Zhu C, Leach JR, Tian B, Cao L, Wen Z, Wang Y, Liu X, Liu Q, Lu J, Saloner D, Hope MD. PMID: 30694008; PMCID: PMC7425182.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. Non-contrast 3D black blood MRI for abdominal aortic aneurysm surveillance: comparison with CT angiography. Eur Radiol. 2017 May; 27(5):1787-1794. Zhu C, Tian B, Leach JR, Liu Q, Lu J, Chen L, Saloner D, Hope MD. PMID: 27553926; PMCID: PMC5323367.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. Clot Through the Heart: Paradoxical Embolism With Thrombus-in-Transit at Multidetector Computed Tomography. J Comput Assist Tomogr. 2015 Jul-Aug; 39(4):598-600. Leach JR, Elicker B, Yee J, Puppula S, Wisneski JA, Yeh BM. PMID: 25756804.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation. Cardiovasc Eng Technol. 2015 Jun; 6(2):105-16. Baillargeon B, Costa I, Leach JR, Lee LC, Genet M, Toutain A, Wenk JF, Rausch MK, Rebelo N, Acevedo-Bolton G, Kuhl E, Navia JL, Guccione JM. PMID: 25984248; PMCID: PMC4427655.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    33. In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology. J Clin Invest. 2012 Jan; 122(1):408-18. Tsai M, Kita A, Leach J, Rounsevell R, Huang JN, Moake J, Ware RE, Fletcher DA, Lam WA. PMID: 22156199; PMCID: PMC3248292.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansCells
    34. Carotid atheroma rupture observed in vivo and FSI-predicted stress distribution based on pre-rupture imaging. Ann Biomed Eng. 2010 Aug; 38(8):2748-65. Leach JR, Rayz VL, Soares B, Wintermark M, Mofrad MR, Saloner D. PMID: 20232151; PMCID: PMC2900591.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    35. Computational Models of Vascular Mechanics. Computational Modeling in Biomechanics. 2010 Jan 1; 99-170. Leach LJ, Mofrad MM, Saloner SD. .
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    36. An efficient two-stage approach for image-based FSI analysis of atherosclerotic arteries. Biomech Model Mechanobiol. 2010 Apr; 9(2):213-23. Leach JR, Rayz VL, Mofrad MR, Saloner D. PMID: 19756798; PMCID: PMC2851741.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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