Rima Arnaout | UCSF Profiles

Rima Arnaout, MD

Title	Assistant Professor
Institution	University of California San Francisco
Department	Medicine
Address	555 Mission Bay Blvd South San Francisco CA 94158
Phone	415-476-6578
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Biography

Education and Training

Massachusetts Institute of Technology, Cambridge, MA	SB	Biology, Bioengineering
Harvard Medical School, Boston, MA	MD	Medicine
Massachusetts General Hospital, Boston, MA		Internal Medicine Residency
University of California, San Francisco, San Francisco, CA		Cardiology Fellowship

Awards and Honors

Sarnoff Cardiovascular Research Foundation	2013 -	2015	Sarnoff Scholar Award
UCSF	2012 -	2013	Pierre and Christine Lamond Research Fellow in Cardiology
NIH	2011 -	2013	National Institutes of Health Loan Repayment Program Award
Sarnoff Cardiovascular Research Foundation	2005 -	2006	Sarnoff Fellow Award
Voice of America	2004 -	2005	AAAS Mass Media Science and Engineering Fellowship Award

Overview

Dr. Rima Arnaout is an Assistant Professor in Medicine (Cardiology) and a member of the UCSF Institute for Computational Health Sciences (ICHS). She is a physician-scientist with a background in genetics, clinical research and programming, and a practicing cardiologist board-certified in multi-modality cardiovascular imaging. Improving the resolution and accuracy of cardiovascular phenotypes will lead to novel insights and therapies. This can occur by drilling down—understanding the genetic and cellular mechanism of a particular disease—or going broad, using computational means to analyze precision phenotypes at scale. Dr. Arnaout is currently developing computational methods to bring precision phenotyping to echocardiography. Her background as a physician-scientist informs the future scope of this work as a technology that can transform non-invasive imaging into a big-data tool for both research and clinical use. She also uses the zebrafish animal model to study cardiovascular developmental gene function and to model human cardiovascular disease.

Interests

Echocardiography, Machine Learning, Multi-modality Imaging, Data Science, Cardiovascular Genetic and Genomics, Heart Development, Congenital Heart Disease, Zebrafish, General Cardiology

Research

Research Activities and Funding

Deep Learning as a New Method for Echocardiographic Data Harmonization in the Cloud
AHA 17IGMV33870001Oct 1, 2017 - Sep 30, 2019
Role: Principal Investigator

Genetics and Structure of Trabecular Myocardium in Development and Disease
NIH K08HL125945Sep 9, 2015 - Aug 31, 2020
Role: Principal Investigator

Adapting GRASP to zebrafish; interrogating the role of endocardial-myocardial interactions on heart development
UCSF Program for Breakthrough Biomedical Research (PBBR) Jul 1, 2014 - Jun 30, 2016
Role: Principal Investigator

Genetic analysis of trabeculated myocardium
Sarnoff Cardiovascular Research Foundation Scholar Award Aug 1, 2013 - Jul 31, 2015
Role: Principal Investigator

Genetic Analyst of Early Conduction System Development
NIH F32HL110489Aug 1, 2011 - Jul 31, 2013
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Guerra A, Germano RF, Stone O, Arnaout R, Guenther S, Ahuja S, Uribe V, Vanhollebeke B, Stainier DY, Reischauer S. Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. Elife. 2018 May 15; 7. PMID: 29762122.

View in: PubMed
Gut P, Reischauer S, Stainier DYR, Arnaout R. LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE. Physiol Rev. 2017 Jul 01; 97(3):889-938. PMID: 28468832.

View in: PubMed
Madani A, Arnaout R, Mofrad M, Arnaout R.. Fast and accurate classification of echocardiograms using deep learning. ArXiv e-prints. 2017; (arXiv:1706).
Brown D, Samsa L, Ito C, Ma H, Arnaout R, Qian L, Liu J.Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. Journal of Molecular and Cellular Medicine. doi: 10.1111/jcmm.13408. 2017.
Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303. PMID: 27066836; PMCID: PMC4832069.

View in: PubMed, PubMed Central
Arnaout R, Reischauer S, Stainier DY. Recovery of adult zebrafish hearts for high-throughput applications. J Vis Exp. 2014 Dec 12; (94). PMID: 25548868.

View in: PubMed
Reischauer S, Arnaout R, Ramadass R, Stainier DY. Actin binding GFP allows 4D in vivo imaging of myofilament dynamics in the zebrafish heart and the identification of Erbb2 signaling as a remodeling factor of myofibril architecture. Circ Res. 2014 Oct 24; 115(10):845-56. PMID: 25228389; PMCID: PMC4371144.

View in: PubMed, PubMed Central
Arnaout R, Stainier DY. Developmental biology: physics adds a twist to gut looping. Curr Biol. 2011 Oct 25; 21(20):R854-7. PMID: 22032191.

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Arnaout R, Thorson A. Late Recognition of Malignant Vasovagal Syncope. Card Electrophysiol Clin. 2010 Jun; 2(2):281-283. PMID: 28770764.

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Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13; 6(5):e109. PMID: 18479184; PMCID: PMC2430899.

View in: PubMed, PubMed Central
Arnaout R, Ferrer T, Huisken J, Spitzer K, Stainier DY, Tristani-Firouzi M, Chi NC. Zebrafish model for human long QT syndrome. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11316-21. PMID: 17592134; PMCID: PMC2040896.

View in: PubMed, PubMed Central