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Rima Arnaout, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    Massachusetts Institute of Technology, Cambridge, MASBBiology, Bioengineering
    Harvard Medical School, Boston, MAMDMedicine
    Massachusetts General Hospital, Boston, MAInternal Medicine Residency
    University of California, San Francisco, San Francisco, CACardiology Fellowship
    Collapse Awards and Honors
    Sarnoff Cardiovascular Research Foundation2013  - 2015Sarnoff Scholar Award
    UCSF2012  - 2013Pierre and Christine Lamond Research Fellow in Cardiology
    NIH2011  - 2013National Institutes of Health Loan Repayment Program Award
    Sarnoff Cardiovascular Research Foundation2005  - 2006Sarnoff Fellow Award
    Voice of America2004  - 2005AAAS Mass Media Science and Engineering Fellowship Award

    Collapse Overview 
    Collapse Overview
    Dr. Rima Arnaout is an Assistant Professor in Medicine (Cardiology) and a member of the UCSF Institute for Computational Health Sciences (ICHS). She is a physician-scientist with a background in genetics, clinical research and programming, and a practicing cardiologist board-certified in multi-modality cardiovascular imaging. Improving the resolution and accuracy of cardiovascular phenotypes will lead to novel insights and therapies. This can occur by drilling down—understanding the genetic and cellular mechanism of a particular disease—or going broad, using computational means to analyze precision phenotypes at scale. Dr. Arnaout is currently developing computational methods to bring precision phenotyping to echocardiography. Her background as a physician-scientist informs the future scope of this work as a technology that can transform non-invasive imaging into a big-data tool for both research and clinical use. She also uses the zebrafish animal model to study cardiovascular developmental gene function and to model human cardiovascular disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Deep Learning as a New Method for Echocardiographic Data Harmonization in the Cloud
    AHA 17IGMV33870001Oct 1, 2017 - Sep 30, 2019
    Role: Principal Investigator
    Genetics and Structure of Trabecular Myocardium in Development and Disease
    NIH/NHLBI K08HL125945Sep 9, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Adapting GRASP to zebrafish; interrogating the role of endocardial-myocardial interactions on heart development
    UCSF Program for Breakthrough Biomedical Research (PBBR) Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Genetic analysis of trabeculated myocardium
    Sarnoff Cardiovascular Research Foundation Scholar Award Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Genetic Analyst of Early Conduction System Development
    NIH/NHLBI F32HL110489Aug 1, 2011 - Jul 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Arnaout R, Nah G, Marcus G, Tseng Z, Foster E, Harris IS, Divanji P, Klein L, Gonzalez J, Parikh N. Pregnancy complications and premature cardiovascular events among 1.6 million California pregnancies. Open Heart. 2019; 6(1):e000927. PMID: 30997125.
      View in: PubMed
    2. Arnaout R. Toward a clearer picture of health. Nat Med. 2019 Jan; 25(1):12. PMID: 30613101.
      View in: PubMed
    3. Guerra A, Germano RF, Stone O, Arnaout R, Guenther S, Ahuja S, Uribe V, Vanhollebeke B, Stainier DY, Reischauer S. Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. Elife. 2018 05 15; 7. PMID: 29762122.
      View in: PubMed
    4. Madani A, Arnaout R, Mofrad M, Arnaout R. Fast and accurate view classification of echocardiograms using deep learning. NPJ Digit Med. 2018; 1. PMID: 30828647.
      View in: PubMed
    5. Gut P, Reischauer S, Stainier DYR, Arnaout R. LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE. Physiol Rev. 2017 07 01; 97(3):889-938. PMID: 28468832.
      View in: PubMed
    6. Madani A, Arnaout R, Mofrad M, Arnaout R.Fast and accurate classification of echocardiograms using deep learning. ArXiv e-prints. 2017; (arXiv:1706).
    7. Brown D, Samsa L, Ito C, Ma H, Arnaout R, Qian L, Liu J.Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. Journal of Molecular and Cellular Medicine. doi: 10.1111/jcmm.13408. 2017.
    8. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303. PMID: 27066836; PMCID: PMC4832069.
      View in: PubMed, PubMed Central
    9. Arnaout R, Reischauer S, Stainier DY. Recovery of adult zebrafish hearts for high-throughput applications. J Vis Exp. 2014 Dec 12; (94). PMID: 25548868.
      View in: PubMed
    10. Reischauer S, Arnaout R, Ramadass R, Stainier DY. Actin binding GFP allows 4D in vivo imaging of myofilament dynamics in the zebrafish heart and the identification of Erbb2 signaling as a remodeling factor of myofibril architecture. Circ Res. 2014 Oct 24; 115(10):845-56. PMID: 25228389.
      View in: PubMed
    11. Arnaout R, Stainier DY. Developmental biology: physics adds a twist to gut looping. Curr Biol. 2011 Oct 25; 21(20):R854-7. PMID: 22032191.
      View in: PubMed
    12. Arnaout R, Thorson A. Late Recognition of Malignant Vasovagal Syncope. Card Electrophysiol Clin. 2010 Jun; 2(2):281-283. PMID: 28770764.
      View in: PubMed
    13. Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 2008 May 13; 6(5):e109. PMID: 18479184; PMCID: PMC2430899.
      View in: PubMed, PubMed Central
    14. Arnaout R, Ferrer T, Huisken J, Spitzer K, Stainier DY, Tristani-Firouzi M, Chi NC. Zebrafish model for human long QT syndrome. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11316-21. PMID: 17592134; PMCID: PMC2040896.
      View in: PubMed, PubMed Central
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