Lisa McConlogue, PhD
|School||UCSF School of Medicine|
|Department||Biochemistry and Biophysics|
|Address||600 16th St|
San Francisco CA 94158
The McConlogue laboratory focuses on both understanding the mechanisms involved in neurodegeneration driven by misfolding-prone proteins and in developing therapeutic approaches to treat neurological diseases such as Alzheimer’s and Parkinson’s diseases (AD and PD). We are particularly interested in understanding the pathogenic role and functional perturbation of intrinsically disordered proteins (IDP) that, due to their unique structural characteristics and key functional roles, lead to diseases of amyloid-type misfolding including cancer and neurodegenerative diseases.
Our current focus is on understanding and blocking the pathogenic processes of a-Synuclein (a-Syn), an IDP that plays a central role in PD and also contributes to AD. We are developing small molecules that act as chaperones restoring the native structure and function of a-Syn under disease conditions to both probe the pathogenic mechanisms of a-Syn misfolding and malfunction, and to develop therapies to treat PD, AD and related diseases.
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