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Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2319091121.
Fote GM, Eapen VV, Lim RG, Yu C, Salazar L, McClure NR, McKnight J, Nguyen TB, Heath MC, Lau AL, Villamil MA, Miramontes R, Kratter IH, Finkbeiner S, Reidling JC, Paulo JA, Kaiser P, Huang L, Housman DE, Thompson LM, Steffan JS. PMID: 39074279.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction. Sci Adv. 2024 Jun 07; 10(23):eadj0385.
Bansal P, Banda EC, Glatt-Deeley HR, Stoddard CE, Linsley JW, Arora N, Deleschaux C, Ahern DT, Kondaveeti Y, Massey RE, Nicouleau M, Wang S, Sabariego-Navarro M, Dierssen M, Finkbeiner S, Pinter SF. PMID: 38848354; PMCID: PMC11160455.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Three dimensional and four dimensional live imaging to study mechanisms of progressive neurodegeneration. J Biol Chem. 2024 Jul; 300(7):107433.
Linsley JW, Reisine T, Finkbeiner S. PMID: 38825007; PMCID: PMC11261153.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls. Nat Commun. 2024 May 02; 15(1):3606.
Tsitkov S, Valentine K, Kozareva V, Donde A, Frank A, Lei S, Answer ALS Consortium, E Van Eyk J, Finkbeiner S, Rothstein JD, Thompson LM, Sareen D, Svendsen CN, Fraenkel E. PMID: 38697975; PMCID: PMC11066062.
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PubMed Mentions: Fields:
Translation:
HumansCells
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A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer's Disease. bioRxiv. 2024 Mar 14.
Jin M, Ma Z, Dang R, Zhang H, Kim R, Xue H, Pascual J, Finkbeiner S, Head E, Liu Y, Jiang P. PMID: 38559257; PMCID: PMC10979994.
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A foundational atlas of autism protein interactions reveals molecular convergence. bioRxiv. 2024 Feb 08.
Wang B, Vartak R, Zaltsman Y, Naing ZZC, Hennick KM, Polacco BJ, Bashir A, Eckhardt M, Bouhaddou M, Xu J, Sun N, Lasser MC, Zhou Y, McKetney J, Guiley KZ, Chan U, Kaye JA, Chadha N, Cakir M, Gordon M, Khare P, Drake S, Drury V, Burke DF, Gonzalez S, Alkhairy S, Thomas R, Lam S, Morris M, Bader E, Seyler M, Baum T, Krasnoff R, Wang S, Pham P, Arbalaez J, Pratt D, Chag S, Mahmood N, Rolland T, Bourgeron T, Finkbeiner S, Swaney DL, Bandyopadhay S, Ideker T, Beltrao P, Willsey HR, Obernier K, Nowakowski TJ, Hüttenhain R, State MW, Willsey AJ, Krogan NJ. PMID: 38076945; PMCID: PMC10705567.
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Enhancing Spatial Transcriptomics Analysis by Integrating Image-Aware Deep Learning Methods. Pac Symp Biocomput. 2024; 29:450-463.
Song J, Lamstein J, Ramaswamy VG, Webb M, Zada G, Finkbeiner S, Craig DW. PMID: 38160299.
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PubMed Mentions: Fields:
Translation:
Humans
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AutoComet: A fully automated algorithm to quickly and accurately analyze comet assays. Redox Biol. 2023 06; 62:102680.
Barbé L, Lam S, Holub A, Faghihmonzavi Z, Deng M, Iyer R, Finkbeiner S. PMID: 37001328; PMCID: PMC10090439.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway. bioRxiv. 2023 Mar 24.
Elsasser S, Elia LP, Morimoto RI, Powers ET, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Finkbeiner S, Gestwicki JE, Richardson RAK, Stoeger T, Tan EP, Xiao Q, Cole CM, Massey LA, Garza D, Kelly JW, Rainbolt TK, Chou CC, Masto VB, Frydman J, Nixon RA. PMID: 36993380; PMCID: PMC10055369.
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PubMed Mentions:
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Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects. Neuron. 2023 04 19; 111(8):1191-1204.e5.
Workman MJ, Lim RG, Wu J, Frank A, Ornelas L, Panther L, Galvez E, Perez D, Meepe I, Lei S, Valencia V, Gomez E, Liu C, Moran R, Pinedo L, Tsitkov S, Ho R, Kaye JA, Answer ALS Consortium, Thompson T, Rothstein JD, Finkbeiner S, Fraenkel E, Sareen D, Thompson LM, Svendsen CN. PMID: 36764301; PMCID: PMC10557526.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism. Cell Genom. 2023 Mar 08; 3(3):100261.
Bressan E, Reed X, Bansal V, Hutchins E, Cobb MM, Webb MG, Alsop E, Grenn FP, Illarionova A, Savytska N, Violich I, Broeer S, Fernandes N, Sivakumar R, Beilina A, Billingsley KJ, Berghausen J, Pantazis CB, Pitz V, Patel D, Daida K, Meechoovet B, Reiman R, Courtright-Lim A, Logemann A, Antone J, Barch M, Kitchen R, Li Y, Dalgard CL, American Genome Center, Rizzu P, Hernandez DG, Hjelm BE, Nalls M, Gibbs JR, Finkbeiner S, Cookson MR, Van Keuren-Jensen K, Craig DW, Singleton AB, Heutink P, Blauwendraat C. PMID: 36950378; PMCID: PMC10025424.
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PubMed Mentions:
11 Fields:
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Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis. bioRxiv. 2023 Jan 20.
Elia L, Herting B, Alijagic A, Buselli C, Wong L, Morrison G, Prado MA, Paulo JA, Gygi SP, Finley D, Finkbeiner S. PMID: 36712069; PMCID: PMC9882405.
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NeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency. Sci Data. 2023 01 11; 10(1):24.
Matlock AD, Vaibhav V, Holewinski R, Venkatraman V, Dardov V, Manalo DM, Shelley B, Ornelas L, Banuelos M, Mandefro B, Escalante-Chong R, Li J, Finkbeiner S, Fraenkel E, Rothstein J, Thompson L, Sareen D, Svendsen CN, NIH NeuroLINCS Consortium, Van Eyk JE. PMID: 36631473; PMCID: PMC9834231.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Nuclear accumulation of host transcripts during Zika Virus Infection. PLoS Pathog. 2023 01; 19(1):e1011070.
Leon KE, Khalid MM, Flynn RA, Fontaine KA, Nguyen TT, Kumar GR, Simoneau CR, Tomar S, Jimenez-Morales D, Dunlap M, Kaye J, Shah PS, Finkbeiner S, Krogan NJ, Bertozzi C, Carette JE, Ott M. PMID: 36603024; PMCID: PMC9847913.
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Translation:
HumansCells
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Fluorescently labeled nuclear morphology is highly informative of neurotoxicity. Front Toxicol. 2022; 4:935438.
Wang S, Linsley JW, Linsley DA, Lamstein J, Finkbeiner S. PMID: 36093369; PMCID: PMC9449453.
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PubMed Mentions:
1
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Huntington's disease iPSC models-using human patient cells to understand the pathology caused by expanded CAG repeats. Fac Rev. 2022; 11:16.
Kaye J, Reisine T, Finkbeiner S. PMID: 35865413; PMCID: PMC9264339.
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PubMed Mentions:
5
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Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases. Front Aging Neurosci. 2022; 14:750629.
Barbé L, Finkbeiner S. PMID: 35592702; PMCID: PMC9110800.
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PubMed Mentions:
1
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Generation of two human induced pluripotent stem cell lines from fibroblasts of Parkinson's disease patients carrying the ILE368ASN mutation in PINK1 (LCSBi002) and the R275W mutation in Parkin (LCSBI004). Stem Cell Res. 2022 05; 61:102765.
Novak G, Finkbeiner S, Skibinski G, Bernini M, Donato C, Skupin A. PMID: 35378365.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022 04 04; 221(4).
Stormo AED, Shavarebi F, FitzGibbon M, Earley EM, Ahrendt H, Lum LS, Verschueren E, Swaney DL, Skibinski G, Ravisankar A, van Haren J, Davis EJ, Johnson JR, Von Dollen J, Balen C, Porath J, Crosio C, Mirescu C, Iaccarino C, Dauer WT, Nichols RJ, Wittmann T, Cox TC, Finkbeiner S, Krogan NJ, Oakes SA, Hiniker A. PMID: 35266954; PMCID: PMC8919618.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. Nat Neurosci. 2022 02; 25(2):226-237.
Baxi EG, Thompson T, Li J, Kaye JA, Lim RG, Wu J, Ramamoorthy D, Lima L, Vaibhav V, Matlock A, Frank A, Coyne AN, Landin B, Ornelas L, Mosmiller E, Thrower S, Farr SM, Panther L, Gomez E, Galvez E, Perez D, Meepe I, Lei S, Mandefro B, Trost H, Pinedo L, Banuelos MG, Liu C, Moran R, Garcia V, Workman M, Ho R, Wyman S, Roggenbuck J, Harms MB, Stocksdale J, Miramontes R, Wang K, Venkatraman V, Holewenski R, Sundararaman N, Pandey R, Manalo DM, Donde A, Huynh N, Adam M, Wassie BT, Vertudes E, Amirani N, Raja K, Thomas R, Hayes L, Lenail A, Cerezo A, Luppino S, Farrar A, Pothier L, Prina C, Morgan T, Jamil A, Heintzman S, Jockel-Balsarotti J, Karanja E, Markway J, McCallum M, Joslin B, Alibazoglu D, Kolb S, Ajroud-Driss S, Baloh R, Heitzman D, Miller T, Glass JD, Patel-Murray NL, Yu H, Sinani E, Vigneswaran P, Sherman AV, Ahmad O, Roy P, Beavers JC, Zeiler S, Krakauer JW, Agurto C, Cecchi G, Bellard M, Raghav Y, Sachs K, Ehrenberger T, Bruce E, Cudkowicz ME, Maragakis N, Norel R, Van Eyk JE, Finkbeiner S, Berry J, Sareen D, Thompson LM, Fraenkel E, Svendsen CN, Rothstein JD. PMID: 35115730; PMCID: PMC8825283.
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PubMed Mentions:
46 Fields:
Translation:
HumansCells
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Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease. Commun Biol. 2022 01 13; 5(1):49.
Novak G, Kyriakis D, Grzyb K, Bernini M, Rodius S, Dittmar G, Finkbeiner S, Skupin A. PMID: 35027645; PMCID: PMC8758783.
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PubMed Mentions:
6 Translation:
HumansCells
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Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2022 01 04; 132(1).
Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Jr RVF. PMID: 34981791; PMCID: PMC8718132.
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2 Fields:
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Superhuman cell death detection with biomarker-optimized neural networks. Sci Adv. 2021 Dec 10; 7(50):eabf8142.
Linsley JW, Linsley DA, Lamstein J, Ryan G, Shah K, Castello NA, Oza V, Kalra J, Wang S, Tokuno Z, Javaherian A, Serre T, Finkbeiner S. PMID: 34878844; PMCID: PMC8654296.
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PubMed Mentions:
4 Fields:
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Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the α-synuclein (SNCA) gene associated with Parkinson's disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007). Stem Cell Res. 2021 Dec; 57:102600.
Novak G, Finkbeiner S, Skibinski G, Skupin A. PMID: 34826737; PMCID: PMC9124237.
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PubMed Mentions: Fields:
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Huntington's disease mouse models: unraveling the pathology caused by CAG repeat expansion. Fac Rev. 2021; 10:77.
Kaye J, Reisine T, Finkbeiner S. PMID: 34746930; PMCID: PMC8546598.
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PubMed Mentions:
9
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Generation of two human induced pluripotent stem cell lines from fibroblasts of unrelated Parkinson's patients carrying the G2019S mutation in the LRRK2 gene (LCSBi005, LCSBi006). Stem Cell Res. 2021 Dec; 57:102569.
Novak G, Finkbeiner S, Skibinski G, Skupin A. PMID: 34736041.
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PubMed Mentions:
1 Fields:
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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. iScience. 2021 Nov 19; 24(11):103221.
NeuroLINCS Consortium, Li J, Lim RG, Kaye JA, Dardov V, Coyne AN, Wu J, Milani P, Cheng A, Thompson TG, Ornelas L, Frank A, Adam M, Banuelos MG, Casale M, Cox V, Escalante-Chong R, Daigle JG, Gomez E, Hayes L, Holewenski R, Lei S, Lenail A, Lima L, Mandefro B, Matlock A, Panther L, Patel-Murray NL, Pham J, Ramamoorthy D, Sachs K, Shelley B, Stocksdale J, Trost H, Wilhelm M, Venkatraman V, Wassie BT, Wyman S, Yang S, NYGC ALS Consortium, Van Eyk JE, Lloyd TE, Finkbeiner S, Fraenkel E, Rothstein JD, Sareen D, Svendsen CN, Thompson LM. PMID: 34746695; PMCID: PMC8554488.
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PubMed Mentions:
17
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Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched. Stem Cell Res. 2021 10; 56:102558.
Reed X, Cobb MM, Skinbinski G, Roosen D, Kaganovich A, Ding J, Finkbeiner S, Cookson MR. PMID: 34626895; PMCID: PMC8655646.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress. Cell Rep. 2021 09 07; 36(10):109685.
Markmiller S, Sathe S, Server KL, Nguyen TB, Fulzele A, Cody N, Javaherian A, Broski S, Finkbeiner S, Bennett EJ, Lécuyer E, Yeo GW. PMID: 34496257.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration. Nat Commun. 2021 09 06; 12(1):5284.
Linsley JW, Shah K, Castello N, Chan M, Haddad D, Doric Z, Wang S, Leks W, Mancini J, Oza V, Javaherian A, Nakamura K, Kokel D, Finkbeiner S. PMID: 34489414; PMCID: PMC8421388.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation. Sci Adv. 2021 Aug; 7(32).
Li H, Doric Z, Berthet A, Jorgens DM, Nguyen MK, Hsieh I, Margulis J, Fang R, Debnath J, Sesaki H, Finkbeiner S, Huang E, Nakamura K. PMID: 34362731; PMCID: PMC8346224.
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PubMed Mentions:
6 Fields:
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ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest. 2021 04 01; 131(7).
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ. PMID: 33792567; PMCID: PMC8011883.
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PubMed Mentions:
2 Fields:
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, et al. PMID: 33634751; PMCID: PMC7996087.
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PubMed Mentions:
986 Fields:
Translation:
HumansAnimalsCells
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Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease. Neurobiol Dis. 2020 12; 146:105088.
Finkbeiner S. PMID: 32977020; PMCID: PMC7686089.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat Commun. 2020 05 07; 11(1):2374.
Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliveira AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. PMID: 32382035; PMCID: PMC7205951.
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PubMed Mentions:
2 Fields:
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The Autophagy Lysosomal Pathway and Neurodegeneration. Cold Spring Harb Perspect Biol. 2020 03 02; 12(3).
Finkbeiner S. PMID: 30936119; PMCID: PMC6773515.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat Commun. 2020 Feb 21; 11(1):1065.
Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Osório Oliveira A, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. PMID: 32081961; PMCID: PMC7035320.
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PubMed Mentions: Fields:
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Approaches to develop therapeutics to treat frontotemporal dementia. Neuropharmacology. 2020 04; 166:107948.
Elia LP, Reisine T, Alijagic A, Finkbeiner S. PMID: 31962288; PMCID: PMC8101984.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019 09 04; 103(5):802-819.e11.
Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, Lewcock JW, Yeo GW. PMID: 31272829; PMCID: PMC6728177.
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PubMed Mentions:
96 Fields:
Translation:
HumansCells
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Cell death assays for neurodegenerative disease drug discovery. Expert Opin Drug Discov. 2019 09; 14(9):901-913.
Linsley JW, Reisine T, Finkbeiner S. PMID: 31179783; PMCID: PMC6663635.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Automated four-dimensional long term imaging enables single cell tracking within organotypic brain slices to study neurodevelopment and degeneration. Commun Biol. 2019; 2:155.
Linsley JW, Tripathi A, Epstein I, Schmunk G, Mount E, Campioni M, Oza V, Barch M, Javaherian A, Nowakowski TJ, Samsi S, Finkbeiner S. PMID: 31069265; PMCID: PMC6494885.
View in:
PubMed Mentions:
18 Translation:
HumansAnimalsCells
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Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway. J Neurosci. 2019 04 24; 39(17):3332-3344.
Elia LP, Mason AR, Alijagic A, Finkbeiner S. PMID: 30696728; PMCID: PMC6788815.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein. mBio. 2018 11 06; 9(6).
Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M. PMID: 30401782; PMCID: PMC6222128.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
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Publisher Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat Commun. 2018 10 15; 9(1):4333.
Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Wong JS, Daub AC, Giorgini F, Finkbeiner S. PMID: 30323191; PMCID: PMC6189116.
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PubMed Mentions:
2 Fields:
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Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nat Commun. 2018 09 28; 9(1):3191.
Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Oliveira AO, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. PMID: 30266909; PMCID: PMC6162324.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520.
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424; PMCID: PMC6247911.
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PubMed Mentions:
61 Fields:
Translation:
Humans
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The Arc of cognition: Signaling cascades regulating Arc and implications for cognitive function and disease. Semin Cell Dev Biol. 2018 05; 77:63-72.
Epstein I, Finkbeiner S. PMID: 29559111; PMCID: PMC5865643.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images. Cell. 2018 04 19; 173(3):792-803.e19.
Christiansen EM, Yang SJ, Ando DM, Javaherian A, Skibinski G, Lipnick S, Mount E, O'Neil A, Shah K, Lee AK, Goyal P, Fedus W, Poplin R, Esteva A, Berndl M, Rubin LL, Nelson P, Finkbeiner S. PMID: 29656897; PMCID: PMC6309178.
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PubMed Mentions:
212 Fields:
Translation:
HumansAnimalsCells
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Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 2018 03 21; 97(6):1267-1288.
Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A, ITALSGEN Consortium, Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L, Genomic Translation for ALS Care (GTAC) Consortium, Moreno CAM, Kamalakaran S, Goldstein DB, ALS Sequencing Consortium, Gitler AD, Harris T, Myers RM, NYGC ALS Consortium, Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC, Answer ALS Foundation, Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J, SLAGEN Consortium, Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C, French ALS Consortium, Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A, Project MinE ALS Sequencing Consortium, Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH, van den Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE. PMID: 29566793; PMCID: PMC5867896.
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PubMed Mentions:
309 Fields:
Translation:
HumansCells
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Assessing microscope image focus quality with deep learning. BMC Bioinformatics. 2018 03 15; 19(1):77.
Yang SJ, Berndl M, Michael Ando D, Barch M, Narayanaswamy A, Christiansen E, Hoyer S, Roat C, Hung J, Rueden CT, Shankar A, Finkbeiner S, Nelson P. PMID: 29540156; PMCID: PMC5853029.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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iPS cells in the study of PD molecular pathogenesis. Cell Tissue Res. 2018 Jul; 373(1):61-77.
Cobb MM, Ravisankar A, Skibinski G, Finkbeiner S. PMID: 29234887; PMCID: PMC5997490.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis. Cell Rep. 2017 05 02; 19(5):919-927.
Ramdzan YM, Trubetskov MM, Ormsby AR, Newcombe EA, Sui X, Tobin MJ, Bongiovanni MN, Gras SL, Dewson G, Miller JML, Finkbeiner S, Moily NS, Niclis J, Parish CL, Purcell AW, Baker MJ, Wilce JA, Waris S, Stojanovski D, Böcking T, Ang CS, Ascher DB, Reid GE, Hatters DM. PMID: 28467905.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes. Neuropsychologia. 2017 Jul 01; 101:57-64.
Possin KL, Kim H, Geschwind MD, Moskowitz T, Johnson ET, Sha SJ, Apple A, Xu D, Miller BL, Finkbeiner S, Hess CP, Kramer JH. PMID: 28427989; PMCID: PMC5765862.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels. J Biol Chem. 2017 02 24; 292(8):3262-3272.
Mason AR, Elia LP, Finkbeiner S. PMID: 28069809; PMCID: PMC5336161.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1165-1170.
Skibinski G, Hwang V, Ando DM, Daub A, Lee AK, Ravisankar A, Modan S, Finucane MM, Shaby BA, Finkbeiner S. PMID: 28028237; PMCID: PMC5293055.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. Hum Mol Genet. 2016 11 01; 25(21):4749-4770.
Mao Y, Chen X, Xu M, Fujita K, Motoki K, Sasabe T, Homma H, Murata M, Tagawa K, Tamura T, Kaye J, Finkbeiner S, Blandino G, Sudol M, Okazawa H. PMID: 28171658.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System. Neuron. 2016 Nov 23; 92(4):780-795.
Martinez FJ, Pratt GA, Van Nostrand EL, Batra R, Huelga SC, Kapeli K, Freese P, Chun SJ, Ling K, Gelboin-Burkhart C, Fijany L, Wang HC, Nussbacher JK, Broski SM, Kim HJ, Lardelli R, Sundararaman B, Donohue JP, Javaherian A, Lykke-Andersen J, Finkbeiner S, Bennett CF, Ares M, Burge CB, Taylor JP, Rigo F, Yeo GW. PMID: 27773581; PMCID: PMC5123850.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016 Sep 22; 6:33861.
Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H. PMID: 27653664; PMCID: PMC5032119.
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PubMed Mentions:
5 Fields:
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Serine 421 regulates mutant huntingtin toxicity and clearance in mice. J Clin Invest. 2016 09 01; 126(9):3585-97.
Kratter IH, Zahed H, Lau A, Tsvetkov AS, Daub AC, Weiberth KF, Gu X, Saudou F, Humbert S, Yang XW, Osmand A, Steffan JS, Masliah E, Finkbeiner S. PMID: 27525439; PMCID: PMC5004962.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. Autophagy. 2016 08 02; 12(8):1418-24.
Moruno Manchon JF, Uzor NE, Finkbeiner S, Tsvetkov AS. PMID: 27467777; PMCID: PMC4968226.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture. Cell Mol Neurobiol. 2016 Apr; 36(3):459-70.
Zhang X, Abels ER, Redzic JS, Margulis J, Finkbeiner S, Breakefield XO. PMID: 26951563; PMCID: PMC5844350.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease. Hum Mol Genet. 2016 05 01; 25(9):1677-89.
Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. PMID: 26920069; PMCID: PMC4986324.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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A three-groups model for high-throughput survival screens. Biometrics. 2016 09; 72(3):936-44.
Shaby BA, Skibinski G, Ando M, LaDow ES, Finkbeiner S. PMID: 26821783; PMCID: PMC4965338.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Cross-species translation of the Morris maze for Alzheimer's disease. J Clin Invest. 2016 Feb; 126(2):779-83.
Possin KL, Sanchez PE, Anderson-Bergman C, Fernandez R, Kerchner GA, Johnson ET, Davis A, Lo I, Bott NT, Kiely T, Fenesy MC, Miller BL, Kramer JH, Finkbeiner S. PMID: 26784542; PMCID: PMC4731157.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.
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PubMed Mentions:
2804 Fields:
Translation:
HumansAnimals
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Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases. Annu Rev Pharmacol Toxicol. 2016; 56:489-510.
Haston KM, Finkbeiner S. PMID: 26514199; PMCID: PMC4868344.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy. Sci Rep. 2015 Oct 19; 5:15213.
Moruno Manchon JF, Uzor NE, Dabaghian Y, Furr-Stimming EE, Finkbeiner S, Tsvetkov AS. PMID: 26477494; PMCID: PMC4609990.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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Sequence-Level Analysis of the Major European Huntington Disease Haplotype. Am J Hum Genet. 2015 Sep 03; 97(3):435-44.
Lee JM, Kim KH, Shin A, Chao MJ, Abu Elneel K, Gillis T, Mysore JS, Kaye JA, Zahed H, Kratter IH, Daub AC, Finkbeiner S, Li H, Roach JC, Goodman N, Hood L, Myers RH, MacDonald ME, Gusella JF. PMID: 26320893; PMCID: PMC4564985.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7821-6.
Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S. PMID: 26056265; PMCID: PMC4485101.
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PubMed Mentions:
69 Fields:
Translation:
HumansCells
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Going retro: ancient viral origins of cognition. Neuron. 2015 Apr 22; 86(2):346-8.
Campioni MR, Finkbeiner S. PMID: 25905805.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Cell-based screening: extracting meaning from complex data. Neuron. 2015 Apr 08; 86(1):160-74.
Finkbeiner S, Frumkin M, Kassner PD. PMID: 25856492; PMCID: PMC4457442.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Dexpramipexole is ineffective in two models of ALS related neurodegeneration. PLoS One. 2014; 9(12):e91608.
Vieira FG, LaDow E, Moreno A, Kidd JD, Levine B, Thompson K, Gill A, Finkbeiner S, Perrin S. PMID: 25526593; PMCID: PMC4272269.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16889-94.
Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS. PMID: 25385587; PMCID: PMC4250109.
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PubMed Mentions:
146 Fields:
Translation:
Animals
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Targeting the low-hanging fruit of neurodegeneration. Neurology. 2014 Oct 14; 83(16):1470-3.
Mason AR, Ziemann A, Finkbeiner S. PMID: 25313376; PMCID: PMC4206158.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson's Disease 2014 conference. Ann Neurol. 2014 Oct; 76(4):469-72.
Sieber BA, Landis S, Koroshetz W, Bateman R, Siderowf A, Galpern WR, Dunlop J, Finkbeiner S, Sutherland M, Wang H, Lee VM, Orr HT, Gwinn K, Ludwig K, Taylor A, Torborg C, Montine TJ, Parkinson's Disease 2014: Advancing Research, Improving Lives Conference Organizing Committee. PMID: 25164235; PMCID: PMC5736367.
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PubMed Mentions:
47 Fields:
Translation:
Humans
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Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease. Front Cell Neurosci. 2014; 8:218.
Margulis J, Finkbeiner S. PMID: 25147502; PMCID: PMC4124811.
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PubMed Mentions:
23
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Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat Chem Biol. 2014 Aug; 10(8):677-85.
Barmada SJ, Serio A, Arjun A, Bilican B, Daub A, Ando DM, Tsvetkov A, Pleiss M, Li X, Peisach D, Shaw C, Chandran S, Finkbeiner S. PMID: 24974230; PMCID: PMC4106236.
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PubMed Mentions:
232 Fields:
Translation:
HumansAnimalsCells
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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. PLoS One. 2014; 9(2):e87133.
Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, Callaway K, Anderson JP, Jobling MF, Buell AK, Yednock TA, Knowles TP, Vendruscolo M, Christodoulou J, Dobson CM, Schenk D, McConlogue L. PMID: 24551051; PMCID: PMC3925190.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest. 2014 Mar; 124(3):981-99.
Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ. PMID: 24509083; PMCID: PMC3938263.
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PubMed Mentions:
161 Fields:
Translation:
HumansAnimalsCells
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Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies. J Neurosci. 2014 Jan 08; 34(2):418-33.
Skibinski G, Nakamura K, Cookson MR, Finkbeiner S. PMID: 24403142; PMCID: PMC3870929.
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PubMed Mentions:
80 Fields:
Translation:
HumansCells
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Executive functions in premanifest Huntington's disease. Mov Disord. 2014 Mar; 29(3):405-9.
You SC, Geschwind MD, Sha SJ, Apple A, Satris G, Wood KA, Johnson ET, Gooblar J, Feuerstein JS, Finkbeiner S, Kang GA, Miller BL, Hess CP, Kramer JH, Possin KL. PMID: 24375511; PMCID: PMC4029327.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nat Genet. 2014 Feb; 46(2):152-60.
Kim HJ, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. PMID: 24336168; PMCID: PMC3934366.
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PubMed Mentions:
218 Fields:
Translation:
HumansAnimalsCells
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PML in the Brain: From Development to Degeneration. Front Oncol. 2013 Sep 17; 3:242.
Korb E, Finkbeiner S. PMID: 24062991; PMCID: PMC3775456.
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PubMed Mentions:
4
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Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013 Sep 10; 2:e00508.
Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. PMID: 24040509; PMCID: PMC3771564.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Startups on the menu. Nat Biotechnol. 2013 Aug; 31(8):680.
Finkbeiner S. PMID: 23929335.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol. 2013 Sep 20; 8(9):1931-8.
Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. PMID: 23841803; PMCID: PMC3938192.
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PubMed Mentions:
31 Fields:
Translation:
Humans
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Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration. Nat Chem Biol. 2013 Sep; 9(9):586-92.
Tsvetkov AS, Arrasate M, Barmada S, Ando DM, Sharma P, Shaby BA, Finkbeiner S. PMID: 23873212; PMCID: PMC3900497.
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PubMed Mentions:
101 Fields:
Translation:
HumansCells
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Targeting H3K4 trimethylation in Huntington disease. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E3027-36.
Vashishtha M, Ng CW, Yildirim F, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, Finkbeiner S, Marsh JL, Housman DE, Fraenkel E, Thompson LM. PMID: 23872847; PMCID: PMC3740882.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci. 2013 Jul; 16(7):874-83.
Korb E, Wilkinson CL, Delgado RN, Lovero KL, Finkbeiner S. PMID: 23749147; PMCID: PMC3703835.
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PubMed Mentions:
81 Fields:
Translation:
AnimalsCells
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Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med. 2013 Jun 05; 5(188):188le2.
Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. PMID: 23740897; PMCID: PMC3936961.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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NUB1 snubs huntingtin toxicity. Nat Neurosci. 2013 May; 16(5):523-5.
Aron R, Tsvetkov A, Finkbeiner S. PMID: 23619755.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease. FEBS Lett. 2013 Apr 17; 587(8):1139-46.
Skibinski G, Finkbeiner S. PMID: 23458259.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Modeling Huntington's disease with induced pluripotent stem cells. Mol Cell Neurosci. 2013 Sep; 56:50-64.
Kaye JA, Finkbeiner S. PMID: 23459227; PMCID: PMC3791169.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4697-702.
Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, Shaw CE, Finkbeiner S, Chandran S. PMID: 23401527; PMCID: PMC3607024.
View in:
PubMed Mentions:
195 Fields:
Translation:
HumansCells
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Longitudinal imaging and analysis of neurons expressing polyglutamine-expanded proteins. Methods Mol Biol. 2013; 1017:1-20.
Tsvetkov AS, Ando DM, Finkbeiner S. PMID: 23719904.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012 Dec; 44(12):1302-9.
Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. PMID: 23104007; PMCID: PMC3510335.
View in:
PubMed Mentions:
142 Fields:
Translation:
HumansAnimalsCells
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Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 11; 122(11):3955-9.
Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. PMID: 23041626; PMCID: PMC3484443.
View in:
PubMed Mentions:
153 Fields:
Translation:
HumansAnimalsCells
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Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS One. 2012; 7(8):e43099.
Wray S, Self M, NINDS Parkinson's Disease iPSC Consortium, NINDS Huntington's Disease iPSC Consortium, NINDS ALS iPSC Consortium, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, Marti-Masso JF, Preza E, Barker S, Sutherland M, Corriveau RA, D'Andrea M, Schapira AH, Uitti RJ, Guttman M, Opala G, Jasinska-Myga B, Puschmann A, Nilsson C, Espay AJ, Slawek J, Gutmann L, Boeve BF, Boylan K, Stoessl AJ, Ross OA, Maragakis NJ, Van Gerpen J, Gerstenhaber M, Gwinn K, Dawson TM, Isacson O, Marder KS, Clark LN, Przedborski SE, Finkbeiner S, Rothstein JD, Wszolek ZK, Rossor MN, Hardy J. PMID: 22952635; PMCID: PMC3428297.
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PubMed Mentions:
25 Fields:
Translation:
HumansCells
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Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. J Neurosci. 2012 Aug 08; 32(32):11109-19.
Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM. PMID: 22875942; PMCID: PMC3546821.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, et al. PMID: 22966490; PMCID: PMC3404883.
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PubMed Mentions:
1814 Fields:
Translation:
HumansAnimals
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Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5803-8.
Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. PMID: 22451909; PMCID: PMC3326463.
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PubMed Mentions:
171 Fields:
Translation:
HumansCells
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Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein. J Biol Chem. 2012 May 04; 287(19):16017-28.
Nucifora LG, Burke KA, Feng X, Arbez N, Zhu S, Miller J, Yang G, Ratovitski T, Delannoy M, Muchowski PJ, Finkbeiner S, Legleiter J, Ross CA, Poirier MA. PMID: 22433867; PMCID: PMC3346083.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure. J Mol Biol. 2012 Aug 24; 421(4-5):587-600.
Peters-Libeu C, Miller J, Rutenber E, Newhouse Y, Krishnan P, Cheung K, Hatters D, Brooks E, Widjaja K, Tran T, Mitra S, Arrasate M, Mosquera LA, Taylor D, Weisgraber KH, Finkbeiner S. PMID: 22306738; PMCID: PMC3358578.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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High-throughput screening in primary neurons. Methods Enzymol. 2012; 506:331-60.
Sharma P, Ando DM, Daub A, Kaye JA, Finkbeiner S. PMID: 22341232; PMCID: PMC3564665.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Protein aggregates in Huntington's disease. Exp Neurol. 2012 Nov; 238(1):1-11.
Arrasate M, Finkbeiner S. PMID: 22200539; PMCID: PMC3909772.
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PubMed Mentions:
167 Fields:
Translation:
HumansAnimalsCells
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A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov; 7(11):1273-94.
Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. PMID: 21997368; PMCID: PMC3359482.
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PubMed Mentions:
135 Fields:
Translation:
Cells
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Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nat Chem Biol. 2011 Oct 30; 7(12):925-34.
Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, Osmand A, Gray M, Thulasiramin V, Saudou F, Segal M, Yang XW, Masliah E, Thompson LM, Muchowski PJ, Weisgraber KH, Finkbeiner S. PMID: 22037470; PMCID: PMC3271120.
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PubMed Mentions:
114 Fields:
Translation:
HumansCells
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Arc in synaptic plasticity: from gene to behavior. Trends Neurosci. 2011 Nov; 34(11):591-8.
Korb E, Finkbeiner S. PMID: 21963089; PMCID: PMC3207967.
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PubMed Mentions:
181 Fields:
Translation:
HumansCells
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Rapid target-specific remodeling of fast-spiking inhibitory circuits after loss of dopamine. Neuron. 2011 Sep 08; 71(5):858-68.
Gittis AH, Hang GB, LaDow ES, Shoenfeld LR, Atallah BV, Finkbeiner S, Kreitzer AC. PMID: 21903079; PMCID: PMC3170520.
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PubMed Mentions:
90 Fields:
Translation:
AnimalsCells
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Huntington's Disease. Cold Spring Harb Perspect Biol. 2011 Jun 01; 3(6).
Finkbeiner S. PMID: 21441583; PMCID: PMC3098678.
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PubMed Mentions:
107 Fields:
Translation:
HumansCells
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Drug discovery in Parkinson's disease-Update and developments in the use of cellular models. Int J High Throughput Screen. 2011 Jun; 2011(2):15-25.
Skibinski G, Finkbeiner S. PMID: 23505333; PMCID: PMC3596173.
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PubMed Mentions:
13
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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem. 2011 Jun 10; 286(23):20710-26.
Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH. PMID: 21489994; PMCID: PMC3121472.
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PubMed Mentions:
302 Fields:
Translation:
HumansAnimalsCells
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A compact beta model of huntingtin toxicity. J Biol Chem. 2011 Mar 11; 286(10):8188-8196.
Zhang QC, Yeh TL, Leyva A, Frank LG, Miller J, Kim YE, Langen R, Finkbeiner S, Amzel ML, Ross CA, Poirier MA. PMID: 21209075; PMCID: PMC3048705.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Bringing SOD1 into the fold. Nat Neurosci. 2010 Nov; 13(11):1303-4.
Barmada S, Finkbeiner S. PMID: 20975748.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Arc regulates spine morphology and maintains network stability in vivo. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18173-8.
Peebles CL, Yoo J, Thwin MT, Palop JJ, Noebels JL, Finkbeiner S. PMID: 20921410; PMCID: PMC2964216.
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PubMed Mentions:
132 Fields:
Translation:
AnimalsCells
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PolyQ disease: too many Qs, too much function? Neuron. 2010 Sep 23; 67(6):897-9.
Kratter IH, Finkbeiner S. PMID: 20869586; PMCID: PMC3989162.
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PubMed Mentions:
23 Fields:
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Bridging the Valley of Death of therapeutics for neurodegeneration. Nat Med. 2010 Nov; 16(11):1227-32.
Finkbeiner S. PMID: 21052079.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimals
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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):16982-7.
Tsvetkov AS, Miller J, Arrasate M, Wong JS, Pleiss MA, Finkbeiner S. PMID: 20833817; PMCID: PMC2947884.
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PubMed Mentions:
127 Fields:
Translation:
AnimalsCells
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Tau reduction prevents Abeta-induced defects in axonal transport. Science. 2010 Oct 08; 330(6001):198.
Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L. PMID: 20829454; PMCID: PMC3024010.
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PubMed Mentions:
255 Fields:
Translation:
AnimalsCells
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Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis. J Neurosci. 2010 Aug 04; 30(31):10541-50.
Miller J, Arrasate M, Shaby BA, Mitra S, Masliah E, Finkbeiner S. PMID: 20685997; PMCID: PMC3078518.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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Conformation sensors that distinguish monomeric proteins from oligomers in live cells. Chem Biol. 2010 Apr 23; 17(4):371-9.
Ramdzan YM, Nisbet RM, Miller J, Finkbeiner S, Hill AF, Hatters DM. PMID: 20416508; PMCID: PMC3564667.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease. J Biol Chem. 2010 Mar 19; 285(12):8808-23.
Landles C, Sathasivam K, Weiss A, Woodman B, Moffitt H, Finkbeiner S, Sun B, Gafni J, Ellerby LM, Trottier Y, Richards WG, Osmand A, Paganetti P, Bates GP. PMID: 20086007; PMCID: PMC2838303.
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PubMed Mentions:
177 Fields:
Translation:
AnimalsCells
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Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis. J Neurosci. 2010 Jan 13; 30(2):639-49.
Barmada SJ, Skibinski G, Korb E, Rao EJ, Wu JY, Finkbeiner S. PMID: 20071528; PMCID: PMC2821110.
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PubMed Mentions:
287 Fields:
Translation:
HumansAnimalsCells
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Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease. Hum Mol Genet. 2010 Jan 01; 19(1):65-78.
Sathasivam K, Lane A, Legleiter J, Warley A, Woodman B, Finkbeiner S, Paganetti P, Muchowski PJ, Wilson S, Bates GP. PMID: 19825844; PMCID: PMC2792149.
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PubMed Mentions:
101 Fields:
Translation:
AnimalsCells
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Pathogenic TARDBP mutations in amyotrophic lateral sclerosis and frontotemporal dementia: disease-associated pathways. Rev Neurosci. 2010; 21(4):251-72.
Barmada SJ, Finkbeiner S. PMID: 21086759.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimals
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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron. 2009 Dec 24; 64(6):828-40.
Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW. PMID: 20064390; PMCID: PMC2807408.
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PubMed Mentions:
174 Fields:
Translation:
HumansAnimalsCells
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009 Dec 28; 187(7):1083-99.
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. PMID: 20026656; PMCID: PMC2806289.
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PubMed Mentions:
190 Fields:
Translation:
HumansAnimalsCells
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High-content screening of primary neurons: ready for prime time. Curr Opin Neurobiol. 2009 Oct; 19(5):537-43.
Daub A, Sharma P, Finkbeiner S. PMID: 19889533; PMCID: PMC2787795.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Protein turnover and inclusion body formation. Autophagy. 2009 Oct; 5(7):1037-8.
Mitra S, Tsvetkov AS, Finkbeiner S. PMID: 19838079; PMCID: PMC2892253.
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PubMed Mentions:
30 Fields:
Translation:
HumansCells
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Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment. J Biol Chem. 2009 Aug 07; 284(32):21647-58.
Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ. PMID: 19491400; PMCID: PMC2755888.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet. 2009 Jun 01; 18(11):1937-50.
Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE. PMID: 19279159; PMCID: PMC2678926.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
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The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci. 2009 Feb 04; 29(5):1525-37.
Pintchovski SA, Peebles CL, Kim HJ, Verdin E, Finkbeiner S. PMID: 19193899; PMCID: PMC2874324.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease. J Biol Chem. 2009 Feb 13; 284(7):4398-403.
Mitra S, Tsvetkov AS, Finkbeiner S. PMID: 19074152; PMCID: PMC2640959.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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The ubiquitin-proteasome pathway in Huntington's disease. ScientificWorldJournal. 2008 Apr 20; 8:421-33.
Finkbeiner S, Mitra S. PMID: 18454252; PMCID: PMC2637619.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007 Sep 06; 55(5):697-711.
Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. PMID: 17785178; PMCID: PMC8055171.
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PubMed Mentions:
792 Fields:
Translation:
HumansAnimalsCells
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RNA decay back in play. Nat Neurosci. 2007 Sep; 10(9):1083-4.
Peebles CL, Finkbeiner S. PMID: 17726472.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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NMDA and AMPA receptors: old channels, new tricks. Trends Neurosci. 2007 Jun; 30(6):284-91.
Rao VR, Finkbeiner S. PMID: 17418904.
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PubMed Mentions:
93 Fields:
Translation:
HumansAnimalsCells
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Disease-modifying pathways in neurodegeneration. J Neurosci. 2006 Oct 11; 26(41):10349-57.
Finkbeiner S, Cuervo AM, Morimoto RI, Muchowski PJ. PMID: 17035516; PMCID: PMC6674695.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimals
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Common threads in neurodegenerative disorders of aging. Alzheimers Dement. 2006 Oct; 2(4):322-6.
Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L. PMID: 19595906.
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3 Fields:
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AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc. Nat Neurosci. 2006 Jul; 9(7):887-95.
Rao VR, Pintchovski SA, Chin J, Peebles CL, Mitra S, Finkbeiner S. PMID: 16732277.
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96 Fields:
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AnimalsCells
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Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J Neurosci. 2006 Jan 25; 26(4):1065-76.
Bradley J, Carter SR, Rao VR, Wang J, Finkbeiner S. PMID: 16436592; PMCID: PMC6674576.
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32 Fields:
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AnimalsCells
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Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 01; 61(Pt 12):1065-8.
Peters-Libeu C, Newhouse Y, Krishnan P, Cheung K, Brooks E, Weisgraber K, Finkbeiner S. PMID: 16511236; PMCID: PMC1978161.
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12 Fields:
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HumansCells
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Automated microscope system for determining factors that predict neuronal fate. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3840-5.
Arrasate M, Finkbeiner S. PMID: 15738408; PMCID: PMC553329.
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78 Fields:
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AnimalsCells
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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004 Oct 14; 431(7010):805-10.
Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. PMID: 15483602.
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817 Fields:
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HumansAnimalsCells
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Using antibodies to analyze polyglutamine stretches. Methods Mol Biol. 2004; 277:103-28.
Brooks E, Arrasate M, Cheung K, Finkbeiner SM. PMID: 15201452.
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12 Fields:
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HumansCells
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Secrets of a secretase: N-cadherin proteolysis regulates CBP function. Cell. 2003 Sep 05; 114(5):533-5.
Rao VR, Finkbeiner S. PMID: 13678577.
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HumansAnimalsCells
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An evaluation of specificity in activity-dependent gene expression in neurons. Prog Neurobiol. 2002 Aug; 67(6):469-77.
Bradley J, Finkbeiner S. PMID: 12385865.
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8 Fields:
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HumansAnimalsCells
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The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev Cell. 2002 Jun; 2(6):831-7.
Humbert S, Bryson EA, Cordelières FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F. PMID: 12062094.
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PubMed Mentions:
203 Fields:
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HumansCells
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New roles for introns: sites of combinatorial regulation of Ca2+- and cyclic AMP-dependent gene transcription. Sci STKE. 2001 Aug 07; 2001(94):pe1.
Finkbeiner S. PMID: 11752669.
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PubMed Mentions:
7 Fields:
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AnimalsCells
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Calcium regulation of the brain-derived neurotrophic factor gene. Cell Mol Life Sci. 2000 Mar; 57(3):394-401.
Finkbeiner S. PMID: 10823240; PMCID: PMC11146979.
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32 Fields:
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HumansAnimalsCells
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CREB couples neurotrophin signals to survival messages. Neuron. 2000 Jan; 25(1):11-4.
Finkbeiner S. PMID: 10707967.
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125 Fields:
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AnimalsCells
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Sending signals from the synapse to the nucleus: possible roles for CaMK, Ras/ERK, and SAPK pathways in the regulation of synaptic plasticity and neuronal growth. J Neurosci Res. 1999 Oct 01; 58(1):88-95.
Curtis J, Finkbeiner S. PMID: 10491574.
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33 Fields:
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HumansAnimalsCells
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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell. 1998 Oct 02; 95(1):55-66.
Saudou F, Finkbeiner S, Devys D, Greenberg ME. PMID: 9778247.
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463 Fields:
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AnimalsCells
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Ca2+ channel-regulated neuronal gene expression. J Neurobiol. 1998 Oct; 37(1):171-89.
Finkbeiner S, Greenberg ME. PMID: 9777740.
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54 Fields:
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AnimalsCells
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To fear or not to fear: what was the question? A potential role for Ras-GRF in memory. Bioessays. 1998 Sep; 20(9):691-5.
Finkbeiner S, Dalva MB. PMID: 9819557.
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1 Fields:
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HumansAnimalsCells
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Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron. 1998 Apr; 20(4):709-26.
Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME. PMID: 9581763.
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572 Fields:
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AnimalsCells
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CREB: a major mediator of neuronal neurotrophin responses. Neuron. 1997 Nov; 19(5):1031-47.
Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME. PMID: 9390517.
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PubMed Mentions:
306 Fields:
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AnimalsCells
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Spatial features of calcium-regulated gene expression. Bioessays. 1997 Aug; 19(8):657-60.
Finkbeiner S, Greenberg ME. PMID: 9264245.
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7 Fields:
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AnimalsCells
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Ca(2+)-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity? Neuron. 1996 Feb; 16(2):233-6.
Finkbeiner S, Greenberg ME. PMID: 8789937.
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51 Fields:
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HumansAnimalsCells
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Glial calcium. Glia. 1993 Oct; 9(2):83-104.
Finkbeiner SM. PMID: 8244537.
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43 Fields:
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HumansAnimalsCells
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Calcium excitability and oscillations in suprachiasmatic nucleus neurons and glia in vitro. J Neurosci. 1992 Jul; 12(7):2648-64.
van den Pol AN, Finkbeiner SM, Cornell-Bell AH. PMID: 1351936; PMCID: PMC6575860.
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50 Fields:
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AnimalsCells
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Calcium waves in astrocytes-filling in the gaps. Neuron. 1992 Jun; 8(6):1101-8.
Finkbeiner S. PMID: 1351732.
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77 Fields:
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AnimalsCells
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Ciprofloxacin interaction with sodium warfarin: a potentially dangerous side effect. Am J Emerg Med. 1991 Nov; 9(6):551-2.
Renzi R, Finkbeiner S. PMID: 1930395.
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4 Fields:
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Humans
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Endothelin induces a sustained rise in intracellular calcium in hippocampal astrocytes. Neurosci Lett. 1991 Feb 11; 123(1):4-8.
Goldman RS, Finkbeiner SM, Smith SJ. PMID: 1905789.
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5 Fields:
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AnimalsCells
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Ca2+ waves in astrocytes. Cell Calcium. 1991 Feb-Mar; 12(2-3):185-204.
Cornell-Bell AH, Finkbeiner SM. PMID: 1647876.
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46 Fields:
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AnimalsCells
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Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science. 1990 Jan 26; 247(4941):470-3.
Cornell-Bell AH, Finkbeiner SM, Cooper MS, Smith SJ. PMID: 1967852.
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496 Fields:
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Cells
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Synthesis and characterization of a series of diarylguanidines that are noncompetitive N-methyl-D-aspartate receptor antagonists with neuroprotective properties. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5631-5.
Keana JF, McBurney RN, Scherz MW, Fischer JB, Hamilton PN, Smith SM, Server AC, Finkbeiner S, Stevens CF, Jahr C, et al. PMID: 2546162; PMCID: PMC297678.
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10 Fields:
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AnimalsCells
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Therapeutic use of magnesium sulfate in selected cases of cerebral ischemia and seizure. N Engl J Med. 1988 Nov 03; 319(18):1224-5.
Goldman RS, Finkbeiner SM. PMID: 3173462.
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10 Fields:
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HumansAnimals
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Applications of quantitative measurements for assessing glutamate neurotoxicity. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):4071-4.
Finkbeiner S, Stevens CF. PMID: 2453886; PMCID: PMC280363.
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PubMed Mentions:
10 Fields:
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AnimalsCells