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Mark Von Zastrow, MD, PhD

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
Address600 16th Street, #N212E
San Francisco CA 94158
Phone415-476-7871
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    Other Positions
    Title(s)Friends of LPPI Endowed Chair for Research in Schizophrenia and Depression

    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Receptors and Second Messengers for Pain and Analgesia
    NIH P01NS053709Sep 1, 2007 - Jun 30, 2013
    Role: Co-Investigator
    2007 Molecular Pharmacology Gordon Research Conference
    NIH R13DA022784Jan 15, 2007 - Dec 31, 2007
    Role: Principal Investigator
    Mechanisms Regulating Endocytosis of Opioid Receptors
    NIH R01DA012864Dec 1, 1999 - May 31, 2021
    Role: Principal Investigator
    Post-endocytic Sorting of Opioid Receptors
    NIH K02DA000439Sep 1, 1999 - Dec 30, 2010
    Role: Principal Investigator
    Membrane Trafficking of Opioid and Adrenergic Receptors
    NIH R01DA010711Jan 15, 1997 - Jan 31, 2019
    Role: Principal Investigator
    MEMBRANE TRAFFICKING OF OPIOID RECEPTORS
    NIH R37DA010711Jan 15, 1997 - Jan 31, 2014
    Role: Principal Investigator
    MEMBRANE TRAFFICKING OF OPIOID RECEPTORS
    NIH R29DA010711Jan 15, 1997 - Mar 31, 2004
    Role: Principal Investigator
    Presynaptic Mechanisms of Neural Plasticity
    NIH P01DA010154Sep 30, 1995 - Apr 30, 2018
    Role: Co-Investigator
    MECHANISMS OF RECEPTOR INTERNALIZATION IN DRUG ADDICTION
    NIH K21DA000218Sep 30, 1994 - Aug 31, 1999
    Role: Principal Investigator
    Extracellular Matrix Protein enhancement of Phagocytosis
    NIH R01GM038330Dec 1, 1986 - Nov 30, 2007
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Selective targeting of mu opioid receptors to primary cilia. Cell Rep. 2024 05 28; 43(5):114164. Fagan RR, Lee DF, Geron M, Scherrer G, von Zastrow M, Ehrlich AT. PMID: 38678559; PMCID: PMC11257377.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. Profiling the proximal proteome of the activated μ-opioid receptor. Nat Chem Biol. 2024 Sep; 20(9):1133-1143. Polacco BJ, Lobingier BT, Blythe EE, Abreu N, Khare P, Howard MK, Gonzalez-Hernandez AJ, Xu J, Li Q, Novy B, Naing ZZC, Shoichet BK, Coyote-Maestas W, Levitz J, Krogan NJ, Von Zastrow M, Hüttenhain R. PMID: 38528119; PMCID: PMC11365811.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    3. β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR. Nat Chem Biol. 2024 03; 20(3):323-332. Blythe EE, von Zastrow M. PMID: 37749347; PMCID: PMC10907292.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    4. Endosomal cAMP production broadly impacts the cellular phosphoproteome. J Biol Chem. 2021 07; 297(1):100907. Tsvetanova NG, Trester-Zedlitz M, Newton BW, Peng GE, Johnson JR, Jimenez-Morales D, Kurland AP, Krogan NJ, von Zastrow M. PMID: 34166681; PMCID: PMC8294583.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    5. Chemical Biology Approaches for Genome-Wide Screening of GPCR Trafficking. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Lobingier LB, Tsvetanova TN, von Zastrow vM. .
      View in: Publisher Site   Mentions:
    6. A High-throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Semesta SK, Tian TR, Kampmann KM, von Zastrow vM, Tsvetanova TN. .
      View in: Publisher Site   Mentions:
    7. Catalytic activation of β-arrestin by GPCRs. Nature. 2018 05; 557(7705):381-386. Eichel K, Jullié D, Barsi-Rhyne B, Latorraca NR, Masureel M, Sibarita JB, Dror RO, von Zastrow M. PMID: 29720660; PMCID: PMC6058965.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    8. Subcellular Organization of GPCR Signaling. Trends Pharmacol Sci. 2018 02; 39(2):200-208. Eichel K, von Zastrow M. PMID: 29478570; PMCID: PMC5830169.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    9. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 2017 04 06; 169(2):350-360.e12. Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ. PMID: 28388416; PMCID: PMC5616215.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansAnimalsCells
    10. Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs. Curr Biol. 2016 12 05; 26(23):3129-3142. Varandas KC, Irannejad R, von Zastrow M. PMID: 27839977; PMCID: PMC5140749.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    11. Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. Mol Pharmacol. 2017 Jan; 91(1):65-73. Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M. PMID: 27821547; PMCID: PMC5198513.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    12. Effects of endocytosis on receptor-mediated signaling. Curr Opin Cell Biol. 2015 Aug; 35:137-43. Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M. PMID: 26057614; PMCID: PMC4529812.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    13. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem. 2015 Mar 13; 290(11):6689-96. Tsvetanova NG, Irannejad R, von Zastrow M. PMID: 25605726; PMCID: PMC4358092.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    14. Retromer mediates a discrete route of local membrane delivery to dendrites. Neuron. 2014 Apr 02; 82(1):55-62. Choy RW, Park M, Temkin P, Herring BE, Marley A, Nicoll RA, von Zastrow M. PMID: 24698268; PMCID: PMC4029335.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    15. Editorial overview: Cell regulation: The ins and outs of G protein-coupled receptors. Curr Opin Cell Biol. 2014 Apr; 27:v-vi. Benovic JL, von Zastrow M. PMID: 24529749.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    16. Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol. 2014; 535:403-18. Irannejad R, Kotowski SJ, von Zastrow M. PMID: 24377936; PMCID: PMC4023871.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. GPCR signaling along the endocytic pathway. Curr Opin Cell Biol. 2014 Apr; 27:109-16. Irannejad R, von Zastrow M. PMID: 24680436; PMCID: PMC4968408.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    18. Modulating neuromodulation by receptor membrane traffic in the endocytic pathway. Neuron. 2012 Oct 04; 76(1):22-32. von Zastrow M, Williams JT. PMID: 23040804; PMCID: PMC3496082.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    19. Science Signaling Podcast: 9 August 2011. Science Signaling. 2011 Aug 9; 4(185). von Zastrow vM, VanHook VA. .
      View in: Publisher Site   Mentions:
    20. Opioid Receptor Trafficking. The Opiate Receptors. 2011 Jan 1; 389-405. von Zastrow vM. .
      View in: Publisher Site   Mentions:
    21. Membrane traffic in the post-genomic era. Genome Biology. 2010 May 1; 11(5):119. Hein HP, von Zastrow vM. .
      View in: Publisher Site   Mentions:
    22. Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications. Drug Alcohol Depend. 2010 May 01; 108(3):166-71. von Zastrow M. PMID: 20338697; PMCID: PMC3417350.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Chapter 27 Agonist-Induced Desensitization and Endocytosis of G-protein-Coupled Receptors. Handbook of Cell Signaling. 2010 Jan 1; 177-183. Tanowitz TM, von Zastrow vM. .
      View in: Publisher Site   Mentions:
    24. Microtubule Plus-End-Tracking Proteins Target Gap Junctions Directly from the Cell Interior to Adherens Junctions. Cell. 2008 Apr 1; 133(2):376. Shaw SR, Fay FA, Puthenveedu PM, von Zastrow vM, Jan JY, Jan JL. .
      View in: Publisher Site   Mentions:
    25. Signaling on the endocytic pathway. Curr Opin Cell Biol. 2007 Aug; 19(4):436-45. von Zastrow M, Sorkin A. PMID: 17662591; PMCID: PMC1992519.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    26. Endocytosis. Encyclopedia of Molecular Cell Biology and Molecular Medicine. 2006 Sep 15. Watson WH, Von Zastrow VM, Wendland WB. .
      View in: Publisher Site   Mentions:
    27. Regulated Membrane Trafficking and Proteolysis of GPCRs. The G Protein-Coupled Receptors Handbook. 2005 Jan 1; 95-105. Hislop HJ, von Zastrow vM. .
      View in: Publisher Site   Mentions:
    28. Identification of Protein Interactions by Yeast Two-Hybrid Screening and Coimmunoprecipitation. Receptor Signal Transduction Protocols. 2004 Jan 1; 259:353-369. Tanowitz TM, von Zastrow vM. .
      View in: Publisher Site   Mentions:
    29. A walk on the wild side (of the synapse). Nature Cell Biology. 2003 Mar 1; 5(3):194-194. von Zastrow vM. .
      View in: Publisher Site   Mentions:
    30. Chapter 31 Agonist-Induced Desensitization and Endocytosis of G-Protein-Coupled Receptors. Handbook of Cell Signaling. 2003 Jan 1; (Adv. Cyclic Nuc. Prot. Phos. Res.201986):181-186. von Zastrow vM. .
      View in: Publisher Site   Mentions:
    31. Intracellular trafficking of epitope-tagged opioid receptors: Different effects of morphine and enkephalin. Peptides. 1994 Nov 1; 54(1):315-316. von Zastrow vM, Keith KD, Zaki ZP, Evans EC. .
      View in: Publisher Site   Mentions:
    32. An approach to the molecular biology of opiate tolerance: identification of opiate-regulated transcripts. NIDA Res Monogr. 1991; 111:85-95. vonZastrow M, Barchas JD, Eberwine JH. PMID: 1775186.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
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