Aliza Ehrlich, PhD

Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
Address600 16th Street, #N216
San Francisco CA 94158
Phone415-476-7871
ORCID ORCID Icon0000-0001-7507-1100 Additional info
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    Collapse Overview
    As an Assistant Professor in the Psychiatry department at UCSF, my research focuses on understanding the neurobiological mechanisms underlying G protein-coupled receptor (GPCR) activation and its impact on neuromodulation. Neuromodulation by GPCRs is a key process required for information processing involved in most behaviors. Psychiatric disorders are believed to in part arise from dysregulation of neuromodulators and therefore the study of GPCR regulation is key to developing new therapies. Additionally, my research focuses on the role of GPCR activation at distinct membrane domains such as the primary cilium and how compartmentalization of receptor signaling impacts psychiatric disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Neuronal G?i-GPCR targeting to primary cilia and impact on cAMP mediated transcription
    NIH K01MH123757Jul 1, 2020 - Jun 30, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chronic tianeptine induces tolerance in analgesia and hyperlocomotion via mu-opioid receptor activation in mice. Front Psychiatry. 2023; 14:1186397. Allain F, Ehrlich AT, McNicholas M, Gross F, Ma W, Kieffer BL, Darcq E. PMID: 37287667; PMCID: PMC10242025.
      View in: PubMed   Mentions:
    2. Visualization of real-time receptor endocytosis in dopamine neurons enabled by NTSR1-Venus knock-in mice. Front Cell Neurosci. 2022; 16:1076599. Ehrlich AT, Couvineau P, Schamiloglu S, Wojcik S, Da Fonte D, Mezni A, von Zastrow M, Bender KJ, Bouvier M, Kieffer BL. PMID: 36523815; PMCID: PMC9745132.
      View in: PubMed   Mentions:
    3. Distinct and sex-specific expression of mu opioid receptors in anterior cingulate and somatosensory S1 cortical areas. Pain. 2023 04 01; 164(4):703-716. Zamfir M, Sharif B, Locke S, Ehrlich AT, Ochandarena NE, Scherrer G, Ribeiro-da-Silva A, Kieffer BL, Séguéla P. PMID: 35973045; PMCID: PMC10026835.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    4. Ackr3-Venus knock-in mouse lights up brain vasculature. Mol Brain. 2021 09 28; 14(1):151. Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BL. PMID: 34583741; PMCID: PMC8477500.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Recent advances in basic science methodology to evaluate opioid safety profiles and to understand opioid activities. Fac Rev. 2021; 10:15. Ehrlich AT, Darcq E. PMID: 33718932; PMCID: PMC7946392.
      View in: PubMed   Mentions: 1  
    6. Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice. ACS Pharmacol Transl Sci. 2019 Aug 09; 2(4):264-274. Nasseef MT, Singh JP, Ehrlich AT, McNicholas M, Park DW, Ma W, Kulkarni P, Kieffer BL, Darcq E. PMID: 32259060; PMCID: PMC7088903.
      View in: PubMed   Mentions: 8  
    7. Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. iScience. 2019 Apr 26; 14:47-57. Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. PMID: 30925410; PMCID: PMC6439305.
      View in: PubMed   Mentions: 31  
    8. Current strategies toward safer mu opioid receptor drugs for pain management. Expert Opin Ther Targets. 2019 04; 23(4):315-326. Ehrlich AT, Kieffer BL, Darcq E. PMID: 30802415; PMCID: PMC6497449.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    9. Recommending buprenorphine for pain management. Pain Manag. 2019 01 01; 9(1):13-16. Ehrlich AT, Darcq E. PMID: 30507294.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. Commun Biol. 2018; 1:102. Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL. PMID: 30271982; PMCID: PMC6123746.
      View in: PubMed   Mentions: 25  
    11. Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks. Biol Psychiatry. 2018 08 01; 84(3):202-212. Ben Hamida S, Mendonça-Netto S, Arefin TM, Nasseef MT, Boulos LJ, McNicholas M, Ehrlich AT, Clarke E, Moquin L, Gratton A, Darcq E, Harsan LA, Maldonado R, Kieffer BL. PMID: 29580570; PMCID: PMC6054571.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    12. Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing. Brain Struct Funct. 2018 Apr; 223(3):1275-1296. Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL. PMID: 29110094; PMCID: PMC5871604.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice. Brain Connect. 2017 10; 7(8):526-540. Arefin TM, Mechling AE, Meirsman AC, Bienert T, Hübner NS, Lee HL, Ben Hamida S, Ehrlich A, Roquet D, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA. PMID: 28882062; PMCID: PMC5653097.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    14. Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Mol Psychiatry. 2018 08; 23(8):1717-1730. Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, Furuyashiki T. PMID: 28924188.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    15. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11603-11608. Mechling AE, Arefin T, Lee HL, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ, Rosa-Neto P, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA. PMID: 27671662; PMCID: PMC5068324.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    16. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. Mol Pharmacol. 2013 Sep; 84(3):476-86. Ehrlich AT, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S. PMID: 23842570.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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